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Tesi sul tema "Protective Immunity"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Al-Dahwi, Zaineb. "Impairment of protective immunity to intestinal helminthiases." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2007. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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2

Ronan, Edward. "Understanding vaccine induced protective immunity to Mycobacterium tuberculosis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:c0d7b20f-e144-42f8-aa52-301d0938b0b3.

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Abstract (sommario):

The current worldwide epidemic of Mycobacterium tuberculosis infection is a huge global health problem. Widespread BCG vaccination remains a useful tool in combating this epidemic; however, its variable efficacy requires urgent development of novel vaccines against Mycobacterium tuberculosis. Such a candidate vaccine is a serotype 5 adenovirus expressing antigen 85A from M. tuberculosis (Ad85A). In animal models Ad85A confers significant protection when administered intra-nasally. The work in this thesis demonstrates that intra-nasal immunisation with Ad85A results in inhibition of M. tubercul

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3

Yu-Lin, Teoh. "Programming CD8 T cell memory development and protective immunity." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491759.

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In order to elicit the ideal set of memory CD8 T cells, rational vaccine design and planning for vaccination regimes require additional knowledge on factors which affect CD8 memory development. Together with the initial conditions under which priming occurs, aspects upstream of the CD8 response such as antigen processing, trafficking and presentation have the ability to influence both the development of the response as well as the type of memory population generated. The exceptional influence of these factors on the resultant CD8 T cell response has led to the concept of CD8 T cell programming

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4

Hicks, Alice Sophie. "Defining biomarkers of protective immunity and disease for tuberculosis." Thesis, St George's, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589943.

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Abstract (sommario):

Tuberculosis (TB) is still a significant global public health problem. The only current vaccine, BCG, gives variable protection, especially in adults. Several new vaccines are currently in clinical trials but no correlates of protective immunity to TB have been defined. Therefore, vaccines have to go through extensive pre-clinical assessments and clinical trials. Once identified, correlates of protection could be used as early end-points during clinical trials, reducing costs and easing the assessment of a greater number of vaccine candidates. In addition, more reliable biomarkers of TB diseas

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5

Vento, Kevin Leon. "Assessment of protective immunity following mucosal vaccination with Pseudomonas aeruginosa." Thesis, St George's, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408031.

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6

Kamuyu, Gathoni. "Identifying merozoite targets of protective immunity against Plasmodium falciparum malaria." Thesis, Open University, 2017. http://oro.open.ac.uk/51139/.

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Abstract (sommario):

The observation that individuals living in malaria endemic regions who are repeatedly infected with <i>P. falciparum</i> can acquire immunity, first to severe, then to uncomplicated clinical episodes of malaria, and finally to high parasite densities, provides hope that a vaccine is achievable. Immunoglobulins have been identified as a key component of naturally acquired immunity and identifying the targets and mechanisms by which this protection is achieved is a clear research priority. To date, only a small proportion of the parasite proteome has been evaluated in the context of naturally ac

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7

Carrillo, Martha. "Studies on protective immunity to toxocara canis in laboratory animals /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487671108307319.

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8

Scheckelhoff, Mark R. "Specific T cell repertoires mediate protective immunity to Histoplasma capsulatum." Cincinnati, Ohio : University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1051292258.

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9

Bereczky, Sándor. "Genetic diversity of Plasmodium falciparum infections : influence on protective malaria immunity /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-548-8/.

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10

Ali, Pirlanta Omer. "Schistosoma mansoni schistosomulum surface epitopes and their relevance to protective immunity." Thesis, Brunel University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253289.

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11

Israelsson, Elisabeth. "The role of antibody mediated parasite neutralization in protective immunity against malaria." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7137.

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12

Lu, Hang. "Induction of protective immunity against chlamydial infection with antigen-pulsed dendritic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0024/MQ51746.pdf.

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13

Infante, Duarte Carmen [Verfasser]. "Antigen-independent pathogenic and protective immunity in chronic neuroinflammation / Carmen Infante Duarte." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1043480854/34.

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14

Manning, Nicola. "Vaccination strategies for cross-protective immunity against African Horse Sickness Virus (AHSV)." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:43bb619c-81fb-4efe-81fc-e7423fa22b24.

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Abstract (sommario):

African Horse Sickness (AHS) is a highly lethal arboviral disease of equines. The lack of treatment makes vaccination essential. However, there are nine AHSV serotypes and AHSV immunity is serotype-specific; therefore AHSV vaccines must protect against all serotypes circulating in the field. A commercial polyvalent live-attenuated vaccine has been used for decades. However, bio-safety risks associated with its use, derived from gene segment re-assortment between vaccine and field strains, prompted the development of safer alternatives. These include the use of recombinant Modified Vaccinia Ank

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15

SCHECKELHOFF, MARK ROBERT. "SPECIFIC T CELL REPERTOIRES MEDIATE PROTECTIVE IMMUNITY TO HISTOPLASMA CAPSULATUM." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1051292258.

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16

SIDOTI, MIGLIORE GIACOMO. "Bacterial lysate enhances protective mucosal immunity via increased expression of antimicrobial peptides." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1047077.

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Abstract (sommario):

Polyvalent mechanical bacterial lysate (PMBL) has been reported to be effective in the prevention of common respiratory tract infections. PMBL are produced through a process that preserves the structure of the bacterial antigens and because of their immunogenic capabilities, increasing importance is given to its mechanism of action, not yet fully understood. Respiratory tract epithelial cells constitute a front-line physical barrier between the organism and the environment. They are able to sense pathogen associated molecular patterns and secrete a wide spectrum of protective factors. By using

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17

Mountford, A. P. "The induction of protective immunity in mice by attenuated larvae of Schistosma mansoni." Thesis, University of York, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381326.

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18

Bancroft, Allison J. "The BALB/c mouse as a model for protective immunity to Brugia pahangi." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333631.

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19

Duprez, Jessica Anais Sybille. "Experimental vaccination for onchocerciasis and the identification of early markers of protective immunity." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28976.

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Abstract (sommario):

Onchocerciasis, caused by Onchocerca volvulus remains a major public health and socio-economic problem across the tropics, despite years of mass drug administration (MDA) with Ivermectin to reduce disease burden. Through modelling, it has been shown that elimination cannot be achieved with MDA alone and additional tools are needed, such as vaccination, which remains the most cost-effective tool for long-term disease control. The feasibility behind vaccination against O. volvulus can be demonstrated in the Litomosoides sigmodontis mouse model, which shows that vaccine induced protection can be

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20

Elliott, Lisa Medicine UNSW. "Correlates of protective immunity in individuals who are exposed to Hepatitis C but appear uninfected." Awarded by:University of New South Wales. Medicine, 2006. http://handle.unsw.edu.au/1959.4/27371.

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Abstract (sommario):

The hepatitis C virus (HCV) currently infects 3% of the world???s population, with chronic infection in 50-80% of exposed individuals. A small subset of individuals who are exposed to HCV do not develop anti-HCV antibodies, persistent viraemia or chronic hepatitis despite generating HCV-specific CD4+ and CD8+ T cells. These individuals are believed to develop an immune response which rapidly clears viraemia prior to the induction of an antibody response. Circumstantial evidence supports the likelihood that some of these individuals may generate these same responses and outcomes on repeated occ

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21

Figueroa, Z. E. F. "Specificity and protective effect of polyclonal antibodies to antigens of Plasmodium berghei and Plamodium chabaudi." Thesis, Open University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304217.

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22

Pasnik, David J. "Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/10157.

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Abstract (sommario):

Recombinant and DNA vaccines utilizing Mycobacterium sp. antigen 85A (Ag85A) were assessed for immunostimulatory and protective effects against M. marinum. Because of their known susceptibility to piscine mycobacteriosis, Morone sp. were utilized as the models for these studies. The first study evaluated a recombinant vaccine with a Brucella abortus strain RB51 vector expressing the Mycobacterium bovis Ag85A. Striped bass (M. saxatilis) were inoculated at doses equivalent to 106, 107, 108, 109, and 1010 colony-forming units/fish. Vaccinated fish demonstrated significant specific humoral and c

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23

Ing, Rebecca Yat Loo 1971. "Mechanisms of innate immunity to blood-stage malaria infection : role of dendritic cells in host-parasite interactions and induction of protective immunity." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102510.

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Abstract (sommario):

A favorable outcome of blood-stage malaria infection requires immune responses that effectively eliminate the infection with minimum pathology to the host. There is strong evidence that the innate immune system is critical for initiating and shaping the subsequent adaptive immune response to blood-stage Plasmodium parasites. As sentinels of infection and potent activators of immunity, dendritic cells (DCs) are pivotally positioned to control the immune response to malaria and thereby influence the outcome of infection. Experiments performed in this thesis work aimed to determine the role of DC

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24

Francisco, Ngiambudulu Mbandu. "The role of cell type-specific tumour necrosis factor in protective immunity against neurotuberculosis." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/8706.

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Includes bibliographical references.<br>Neurotuberculosis is the most severe form of extra-pulmonary tuberculosis, characterised by the formation of rich foci a brain form of granulomas, and tuberculous meningitis. Granulomas contain mycobacteria by recruitment of immune cells that surround the bacteria. The cytokine tumour necrosis factor has been found to be involved in the recruitment of the immune cells and structure maintenance of granulomas. Tumour necrosis factor is a multifunctional proinflammatory cytokine which play a critical role in the initial and long-term host immune protection

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25

Darby, Matthew G. "Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells". Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/14954.

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Includes bibliographical references.<br>Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role

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26

Braun, Jan Matthias. "The role of commensal bacteria in the development of protective immunity to meningococcal disease." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22775.

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Abstract (sommario):

<i>Neisseria meningitidis</i> (NM) is a major pathogen associated with severe and often fatal meningitis and septicaemia world-wide. Effective vaccines based on the capsular antigens for serogroups A,C,W135 and Y are available. The capsule of serogroup B, responsible for much of the endemic disease in industrialised countries, is not immunogenic and other approaches to development of an effective vaccine are being examined. Carriage of the commensal species <i>Neisseria lactamica</i> (NL) and <i>Moraxella catarrhalis</i> (MC) coincides with progressive increase in the level of natural immunity

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27

Constant, Stephanie Louise. "The induction of protective immunity to Schistosoma mansoni in mice : in vivo lymphocyte responses in the draining lymph nodes." Thesis, University of York, 1991. http://etheses.whiterose.ac.uk/10854/.

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28

Zhang, Wenbao. "Echinococcus granulosus : studies of protective immunity, and the isolation and characterisation of stage-specific genes /." [St. Lucia, Qld.], 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17257.pdf.

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29

Lechner, Christian [Verfasser], and Peter [Akademischer Betreuer] Soboslay. "Immune Regulation and Protective Immunity during Helminth and Protozoan Infections / Christian Lechner ; Betreuer: Peter Soboslay." Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1162897252/34.

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30

Hirst, Ian David. "Characterisation of the iron uptake mechanisms of Aeromonas Salmonicida : role in virulence and protective immunity." Thesis, University of Stirling, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317419.

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31

Patel, Rajen. "Dendritic Cells Mediate Protective Immunity Against Salmonella Typhimurium by Regulating Antigen Presentation, Inflammation and Cell Death." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34307.

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Abstract (sommario):

Salmonella enterica serovar Typhimurium (ST) is an intracellular bacterium that resides within the phagosome of infected cells. ST is the causative agent of gastroenteritis in humans and typhoid like disease in mice. ST infects epithelial cells and phagocytic cells such as dendritic cells (DCs), which are immune sentinels that have been regarded as the most critical antigen-presenting cell (APC). I evaluated the role of CD8α DCs, a subset of DCs capable of antigen presentation of phagosomal pathogens to activate CD8+ T cells. Furthermore, I assessed the role of key cytokines such as the group

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32

Kleynhans, Leanie. "The impact of the steroid hormones medroxyprogesterone acetate, cortisol and progesterone on protective immunity to tuberculosis." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20371.

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Thesis (PhD)--Stellenbosch University, 2012.<br>Bibliography<br>ENGLISH ABSTRACT: Most individuals latently infected with Mycobacterium tuberculosis (Mtb) contain the infection by a balance of effector and regulatory immune responses. However, this balance can be influenced by steroid hormones such as glucocorticoids (GCs), which are known to increase the risk of reactivation of TB. The contraceptive medroxyprogesterone acetate (MPA), which also possesses selective glucocorticoid activity, is widely used in developing countries with approximately 60% of women on contraceptives using MPA i

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33

Thompson, Bridget. "Murine acute myeloid leukemia cells expressing the cytosine deaminase gene induce protective immunity to parental leukemic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ54149.pdf.

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34

Rapp, Ulrike. "Achieving protective immunity against intracellular bacterial pathogens a study on the efficiency of Gp96 as a vaccine carrier /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971616167.

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35

Contreras, Rojas Andrea Paz. "Brucella abortus RB51 vaccine: Testing its Spectrum of Protective and Curative Characteristics." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/28887.

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Abstract (sommario):

Brucella abortus (BA) are gram-negative, facultative intracellular bacteria that cause abortions in cattle and debilitating illness in humans. The US is now virtually free of bovine brucellosis, but the disease is endemic in wildlife. The official brucellosis vaccine in the US is strain RB51 (RB51). It elicits protective cell-mediated immunity (CMI) against BA infections. Mycobacterium avium subspecies paratuberculosis (MAP) causes paratuberculosis in ruminants. It is a slow growing intracellular parasite that requires CMI for its control, belongs to the genus Mycobacterium, and is closely r

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36

Prince, Amanda L. "The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/660.

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Abstract (sommario):

T cell development in the thymus produces multiple lineages of cells, including conventional naïve CD4+ and CD8+ T cells, regulatory T cells, and innate T cells. Innate T cells encompass γδ T cells, invariant natural killer (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and H2-M3-restricted cells (Berg, 2007). Although they are a minor subset of all thymocytes, innate T cells develop in the thymus and share characteristics of the innate and adaptive immune systems (Berg, 2007). These lymphocytes undergo antigen receptor rearrangement and are able to exert their effector function im

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37

Prince, Amanda L. "The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/660.

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Abstract (sommario):

T cell development in the thymus produces multiple lineages of cells, including conventional naïve CD4+ and CD8+ T cells, regulatory T cells, and innate T cells. Innate T cells encompass γδ T cells, invariant natural killer (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and H2-M3-restricted cells (Berg, 2007). Although they are a minor subset of all thymocytes, innate T cells develop in the thymus and share characteristics of the innate and adaptive immune systems (Berg, 2007). These lymphocytes undergo antigen receptor rearrangement and are able to exert their effector function im

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38

Mugyenyi, Cleopatra Kama. "The acquisition and maintenance of antibodies to merozoite antigens of Plasmodium falciparum and their role in protective immunity to malaria." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522224.

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39

Cheramie, Martin N. "Investigations into Mycobacterium marinum Interacting and Crossing Fish Gut Epithelia| Evidence for Inducing a Protective Gut Mucosal Immunity by a Live Vaccine Candidate." Thesis, University of Louisiana at Lafayette, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1585851.

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<p> <i>Mycobacterium marinum</i> is an established surrogate pathogen for <i>Mycobacterium tuberculosis</i> because of <i>M. marinum </i>'s strong conservation of thousands of orthologous genes, lower risk, lower financial burden to researchers, and similar pathology in fish. This pathogen causes TB-like chronic disease in a wide variety of fish species and can mount superficial infection of human tissues. As in human TB, the microbe grows within the host macrophages, can mount life-long chronic infections, and produces granulomatous lesions in target organs. One of the fish species known to m

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40

Jobsri, Jantipa. "Induction of protective antigen-specific anti-tumour immunity using vaccines incorporating immunoenhancing properties of the coat protein from the potato virus X (PVX)." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/362530/.

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DNA fusion vaccines encoding the idiotypic (Id) single chain variable fragments of B-cell malignancies fused to the potato virus X coat protein (PVXCP) were shown to enhance anti Id antibody and T-cell responses which resulted in protection in lymphoma and myeloma models. I further explored the use of PVXCP to enhance induction of anti -tumour immunity. The aims of this study were to generate two types of Id tumour vaccines against the BCL1 lymphoma, a multimeric Id-PVXCP fusion protein and a PVX particle displaying Id antigen, and to compare their performance with the DNA fusion vaccine. The

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41

Musasia, Fauzia Khagai [Verfasser], and Michael [Akademischer Betreuer] Lanzer. "Antibody mediated clearance of ring-infected erythrocytes as a mechanism of protective immunity against Plasmodium falciparum malaria / Fauzia Khagai Musasia ; Betreuer: Michael Lanzer." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1206347864/34.

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42

Roy, Eleanor. "Response of dendritic cells to Mycobacterium tuberculosis infection and the induction of protective immunity using dendritic cells infected with an auxotrophic mutant of M. tuberculosis." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446801/.

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Abstract (sommario):

Mycobacterium tuberculosis, the aetiological agent of tuberculosis, is an intracellular pathogen commonly infecting macrophages, and has also been shown to infect dendritic cells (DC). As DC are particularly effective antigen-presenting cells, it is likely that they play a principle role in initiating anti-mycobacterial T cell responses. This work investigates the activation of DC in response to M. tuberculosis infection using murine bone marrow-derived DCs, generated in the presence of granulocyte- macrophage colony-stimulating factor (GM-CSF). It was found that both unsorted DC populations a

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43

Alaofi, Youssef Ali D. "The impact of the classical, lectin and alternative pathways of complement activation on protective immunity against Streptococcus pneumoniae infection following vaccination with established pneumococcal vaccines." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/42421.

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Abstract (sommario):

Streptococcus pneumoniae (S. pneumoniae) is a pathogen that can cause infectious disease, such as meningitis, septicaemia and pneumonia. As part of innate immunity, the complement system plays a major role in the immune response to S. pneumoniae. Given this, the aim was to determine the impact of selective deficiencies for classical, lectin and alternative pathways of complement activation on vaccination response using pneumococcal polysaccharide vaccines. All results were achieved using CRM197 (a non-toxic mutant of diphtheria toxin), which elicited a different immune response in comparison t

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44

Barker, Christopher Jon. "Identification and characterization of novel candidates for a vaccine against chlamydial genital tract infection." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16487/1/Christopher_Barker_Thesis.pdf.

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Abstract (sommario):

Chlamydia trachomatis is a human pathogen of the genital tract and ocular epithelium. It is an obligate intracellular parasite with a unique biphasic development cycle. C.trachomatis infection is the most common bacterial sexually transmitted disease in industrialized nations. Its ability to cause chronic disease makes it a serious economic burden and health threat to developed and developing countries. Although treatable, approximately 70% of C.trachomatis infections are asymptomatic, potentially leading to the development of chronic sequelae. Furthermore, chlamydial genital tract infection h

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45

Barker, Christopher Jon. "Identification and characterization of novel candidates for a vaccine against chlamydial genital tract infection." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16487/.

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Abstract (sommario):

Chlamydia trachomatis is a human pathogen of the genital tract and ocular epithelium. It is an obligate intracellular parasite with a unique biphasic development cycle. C.trachomatis infection is the most common bacterial sexually transmitted disease in industrialized nations. Its ability to cause chronic disease makes it a serious economic burden and health threat to developed and developing countries. Although treatable, approximately 70% of C.trachomatis infections are asymptomatic, potentially leading to the development of chronic sequelae. Furthermore, chlamydial genital tract infection h

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46

Brenneman, Karen Elaine. "Investigation and characterization of the enhanced humoral response following immunization with the lethal and edema toxins of bacillus anthracis." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174317572.

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47

O’Meara, Connor Patrick. "The development of an effective vaccine against Chlamydia : utilisation of a non-toxic mucosal adjuvant to generate a protective mucosal response." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/61614/1/Connor_O%27Meara_Thesis.pdf.

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Abstract (sommario):

Chlamydia is responsible for a wide range of diseases with enormous global economic and health burden. As the majority of chlamydial infections are asymptomatic, a vaccine has greatest potential to reduce infection and disease prevalence. Protective immunity against Chlamydia requires the induction of a mucosal immune response, ideally, at the multiple sites in the body where an infection can be established. Mucosal immunity is most effectively stimulated by targeting vaccination to the epithelium, which is best accomplished by direct vaccine application to mucosal surfaces rather than by inje

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48

Kimoto, Terumi. "Differences in gamma interferon production induced by listeriolysin O and ivanolysin O result in different levels of protective immunity in mice infected with Listeria monocytogenes and Listeria ivanovii." Kyoto University, 2003. http://hdl.handle.net/2433/148467.

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Evert, Benjamin J. "Applications of polyhydroxy butyrate bead technology." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/411889.

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Abstract (sommario):

Recent research into bioengineered polyhydroxy butyrate (PHB) bead technology has resulted in the ability to generate functional polyester nanoparticles and materials with diverse applications across many fields of science. Through protein engineering and by hijacking Escherichia coli as a high yielding cell factory the Rehm lab group has been able to generate hundreds of PHB beads coated in various target proteins for multiple applications. The possible applications of this technology are only limited by our own ideas for targets which can be applied to the PHB bead technology. PHB beads coat

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Masic, Anita [Verfasser], and Heidrun [Akademischer Betreuer] Moll. "Signaling via Interleukin-4 Receptor alpha chain during dendritic cell–mediated vaccination is required to induce protective immunity against Leishmania major in susceptible BALB/c mice / Anita Masic. Betreuer: Heidrun Moll." Würzburg : Universitätsbibliothek der Universität Würzburg, 2013. http://d-nb.info/1031379762/34.

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