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Artykuły w czasopismach na temat „Β-hCG”

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Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Kuss, Erich. "HCG or β-hCG or hCG β-subunit or hCG + hCG β-subunit?" American Journal of Obstetrics and Gynecology 164, № 6 (1991): 1689. http://dx.doi.org/10.1016/0002-9378(91)91461-5.

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Crabb, Simon J., Adam Sharp, Julia Head та ін. "Investigating serum β-HCG as an independent prognostic factor in patients (pts) receiving chemotherapy (Ct) for transitional cell carcinoma (TCC) of the urothelial tract." Journal of Clinical Oncology 31, № 15_suppl (2013): 4549. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4549.

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4549 Background: Serum human chorionic gonadotrophin β subunit (β-HCG) has prognostic value in TCC but has not been investigated in pts receiving Ct for this disease. Furthermore prior studies lacked statistical power to test independence from other prognostic variables. Methods: A single institution retrospective clinical database was constructed of pts receiving Ct between 2005 and 2011 for cancer of the urothelial tract. Eligible pts had pure or a component of TCC. Prognostic variables were tested by univariate Kaplan Meier analyses. Statistically significant variables were then assessed by

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Cao, Zhimin (Tim), and Robert Rej. "Are Laboratories Reporting Serum Quantitative hCG Results Correctly?" Clinical Chemistry 54, no. 4 (2008): 761–64. http://dx.doi.org/10.1373/clinchem.2007.098822.

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Abstract Background: Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone that exists in multiple forms. Immunoassays commonly used in clinical laboratories measure intact hCG, total β hCG (intact hCG + hCG free β-subunit), and/or hCG free β-subunit. Measurement of serum concentrations of hCG is useful for confirmation and monitoring of pregnancy, diagnosis of trophoblastic diseases and monitoring of the efficacy of treatment, and prenatal screening. Correctly reporting results for the various forms of hCG is clinically important. Method: We prepared samples by addition o

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Sengodan, Satheesh Kumar, Sreelatha K. Hemalatha, Revathy Nadhan та ін. "β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue". Carcinogenesis 40, № 11 (2019): 1415–26. http://dx.doi.org/10.1093/carcin/bgz070.

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Abstract β-hCG expression in breast cancer is highly controversial with reports supporting both protective and tumorigenic effects. It has also been reported that risk of breast cancer at an early age is increased with full-term pregnancies if a woman is a BRCA1 mutation carrier. We have already demonstrated that BRCA1-defective cells express high levels of β-hCG and that when BRCA1 is restored, β-hCG level is reduced. Also, BRCA1 can bind to the promoter and reduce the levels of β-hCG. β-hCG induces tumorigenicity in BRCA1-defective cells by directly binding to TGFBRII and induces TGFBRII-med

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Li, Jiali, Mingzhu Yin, Wanjing Song, et al. "B Subunit of Human Chorionic Gonadotropin Promotes Tumor Invasion and Predicts Poor Prognosis of Early-Stage Colorectal Cancer." Cellular Physiology and Biochemistry 45, no. 1 (2018): 237–49. http://dx.doi.org/10.1159/000486770.

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Background/Aims: It is well established that many non-trophoblastic tumors secrete HCG (human chorionic gonadotropin) and that such secretion is correlated with the poor prognosis of tumor patients. This study aims to analyze the correlation between β-HCG expression and outcome of colorectal cancer (CRC) and understand its role in CRC pathology Methods: We detected the mRNA and protein expression of β-HCG in human CRC tissues with RT-qPCR and immunohistochemistry, and we compared the clinical-pathological characteristics, prognosis and progression between the β-HCG positive and negative groups

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6

Iles, R. K., C. L. Lee, I. Howes, S. Davies, R. Edwards та T. Chard. "Immunoreactive β-core-like material in normal postmenopausal urine: human chorionic gonadotrophin or LH origin? Evidence for the existence of LH core". Journal of Endocrinology 133, № 3 (1992): 459–66. http://dx.doi.org/10.1677/joe.0.1330459.

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ABSTRACT Material with the immunochemical properties of the β-core of human chorionic gonadotrophin (hCG) can be found in the urine of normal postmenopausal women. However, we have been unable to detect intact hCG (using an assay which is specific for the α–β heterodimer of intact hCG) in serum of such subjects. The levels of serum LH and urinary β-core were compared in matched samples from 28 women (serum LH: median 27 U/l, range 4-70 U/l, urinary β-core: median 0·27 μg/l, range < 0·05–0·645 μg/l). Urine (4 litres) from three postmenopausal women was concentrated, dialysed and subjected to

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7

Pokharel, Khageshwor, Peter J. Gilbar, Scott K. Mansfield, Lekshmi M. Nair, and Albertina So. "Elevated beta human chorionic gonadotropin in a non-pregnant female diagnosed with anal squamous cell carcinoma." Journal of Oncology Pharmacy Practice 26, no. 5 (2019): 1266–69. http://dx.doi.org/10.1177/1078155219893428.

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Introduction Elevated serum beta human chorionic gonadotrophin (β-hCG) in a female normally indicates pregnancy or possibly, gestational trophoblastic disease or ovarian germ cell tumours. Expression of β-hCG has been demonstrated in cervical and endometrial carcinoma and other non-germ cell tumours of the ovary, vulva, breast, prostate, lung, colon, oral/facial tissue and stomach. Case report We report a 43-year-old premenopausal woman with p16 positive squamous cell anal cancer. Pre-treatment urinary screening was positive for β-hCG (218 IU/L), which was confirmed on serum and expressed in t

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8

Patel, Bijal, Sharifeh Kamalimotlagh, Nilesh Patel, and Richard W. Pinsker. "To Be or Not to Be: Pregnant or Not." Journal of the Endocrine Society 5, Supplement_1 (2021): A785. http://dx.doi.org/10.1210/jendso/bvab048.1597.

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Abstract Background: Beta Human chorionic gonadotropin (β-hCG) is used for diagnosing pregnancy. Differential diagnosis for elevated β-hCG includes false positive test due to antibody interference, gestational trophoblastic disease (GTD), pituitary production of β-hCG or non-gestational malignancies including hepatic, neuroendocrine, breast, ovarian, pancreatic, cervical, and gastric cancers. We are presenting a case of a menopausal woman noted to have persistently positive serum pregnancy test. Case: 42-year-old female (G3 P2 A1) with a history of thyroid nodules and hypothyroidism was referr

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9

P, Dr Bindu. "Effect of Pre Evacuation Serum Β hCG Levels on Post Evacuation Β hCG Regression in Molar Pregnancy". Journal of Medical Science And clinical Research 05, № 05 (2017): 21734–40. http://dx.doi.org/10.18535/jmscr/v5i5.82.

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D., Muthulakshmi, Sasirekha R. та Medha R. "Serum β-hcg levels between 12 to 20 weeks of gestation in prediction of hypertensive disordrers of pregnancy". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, № 8 (2017): 3347. http://dx.doi.org/10.18203/2320-1770.ijrcog20173263.

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Background: This study was undertaken to study the association of serum β hCG levels between 12 to 20 weeks of gestation and development of hypertensive disorders of pregnancy and to assess the association between the levels of β hCG and severity of hypertensive disorders of pregnancy. Study design: Prospective cohort study (200 uncomplicated primigravida).Methods: All women between 12 to 20 weeks of pregnancy meeting the selection criteria, attended antenatal OPD in JIPMER were recruited for this study after informed consent. The venous blood samples were obtained from the subjects for β-hCG

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11

Yuan, Lihua, Lingyu Yu, Zhengao Sun та ін. "Association between 7-day serum β-hCG levels after frozen–thawed embryo transfer and pregnancy outcomes: a single-centre retrospective study from China". BMJ Open 10, № 10 (2020): e035332. http://dx.doi.org/10.1136/bmjopen-2019-035332.

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ObjectiveEarly monitoring of plasma human chorionic gonadotropin (β-hCG) level is vital in predicting pregnancy outcome. This study investigated the predictive value of serum β-hCG level on the seventh day after frozen–thawed embryo transfer (FET) for ongoing pregnancy (OP) and adverse pregnancy (AP).DesignRetrospective study.SettingThe Reproductive and Genetic Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China.Participants1061 pregnant women who underwent FET between January 2014 and January 2017.Primary and secondary outcome measuresPregnancy outc

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12

Kour, Gurpreet, та Sandeep Kour. "Serum β-hCG Levels Between 13-20 Weeks Gestation Can Predict Development of Pregnancy Induced Hypertension". Nepal Journal of Obstetrics and Gynaecology 13, № 1 (2018): 12–14. http://dx.doi.org/10.3126/njog.v13i1.21609.

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Aims: To find out predictive value of Serum β Human Chorionic Gonadotropin (β HCG) levels between 13-20 weeks of gestation in predicting the development of pregnancy induced hypertension (PIH) or pre-eclampsia, eclampsia.Methods: Serum β HCG level was estimated in 200 normotensive patients between 13-20 weeks of gestation. The median value of Serum β HCG was calculated and patients were divided into two groups as per two times Multiple of Median (2MOM) values of Serum β HCG i.e. those above and below the 2MOM values. The patients were followed up to delivery and were evaluated for the developm

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13

Iles, R. K., B. H. Czepulkowski, B. D. Young та T. Chard. "Amplification or rearrangement of the β-human chorionic gonadotrophin (β-hCG)—human LH gene cluster is not responsible for the ectopic production of β-hCG by bladder tumour cells". Journal of Molecular Endocrinology 2, № 2 (1989): 113–17. http://dx.doi.org/10.1677/jme.0.0020113.

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ABSTRACT The β-subunit of human chorionic gonadotrophin (hCG) is coded on chromosome 19 by the β-hCG-hLH gene cluster. Genomic DNA has been isolated from bladder tumour cell lines which ectopically express β-hCG. The β-hCG—hLH gene cluster was probed for possible rearrangement or amplification and cells karyotyped for chromosome 19 abnormalities. No rearrangement or amplification of the gene cluster and no consistent abnormalities of chromosome 19 were found. The expression of β-hCG by bladder tumours is therefore likely to be the result of altered gene regulation and not a rearrangement or am

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14

Ben Kridis, W., R. Ben Hassena, S. Charfi та ін. "GASTRIC SIGNET-RING CELL CARCINOMA WITH HYPERSECRETION OF β-HUMAN CHORIONIC GONADOTROPIN AND REVIEW OF THE LITERATUR". Experimental Oncology 40, № 2 (2018): 149–51. http://dx.doi.org/10.31768/2312-8852.2018.40(2):149-151.

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β-Human chorionic gonadotropin (β-HCG) is an embryonic protein secreted by the syncytiotrophoblast of the placenta. The determination of the plasma β-HCG level is routinely used for the diagnosis and the follow-up of germ cell tumors. Some adenocarcinomas have been described as being rarely associated with β-HCG hypersecretion. We report a case of gastric signet-ring cell carcinoma with β-HCG hypersecretion and propose hypotheses to explain the pathogenesis of such hypersecretion.

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15

Wide, Mariann, Håkan Persson, Örjan Lundkvist та Leif Wide. "Localization of mRNA for the β-subunit of placental hCG by in situ hybridization". Acta Endocrinologica 119, № 1 (1988): 69–74. http://dx.doi.org/10.1530/acta.0.1190069.

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Abstract. The cellular origin of placental hCG is not yet completely established. Depending on the method used, the syncytium, cytotrophoblast or both types of tissue have been claimed to synthesize hCG. In the present study in situ hybridization was used on sections of chorionic villi in order to detect expression of the gene for the β-subunit of hCG (β-hCG). Placental tissue was obtained from the 8th to the 11th weeks of pregnancy, when the concentration of hCG is high. A cDNA clone, encoding the entire amino acid sequence of β-hCG, was used as a probe. Hybrids of β-hCG cDNA/mRNA were found

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16

Murphy, Patrick, Karla Machlab, Shahd Almohsen, Jennifer Fratesi та Geoffrey Watson. "β-hCG secreting uterine PEComa". BMJ Case Reports 17, № 1 (2024): e256641. http://dx.doi.org/10.1136/bcr-2023-256641.

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A postmenopausal female patient presented with vaginal bleeding. Initial bloodwork revealed an elevated serum beta human chorionic gonadotropin level (β-hCG). Pelvic MRI identified a complex heterogeneous uterine mass with central necrosis. She underwent total abdominal hysterectomy with bilateral saplingo-oopherectomy. Pathology reported a malignant perivascular epithelioid cell tumour (PEComa). Postoperatively, her β-hCG level returned to normal. β-hCG secreting sarcomas are extremely rare, and to our knowledge, there has only been one previously reported case of a β-hCG secreting PEComa. Ba

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17

Rau, Cheng-shyuan, Jui-wei Lin, Cheng-loong Liang, Tao-chen Lee, Han-jung Chen та Kang Lu. "Production of human chorionic gonadotropin—β subunit associated with an osteolytic meningioma". Journal of Neurosurgery 97, № 1 (2002): 197–99. http://dx.doi.org/10.3171/jns.2002.97.1.0197.

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✓ An osteolytic meningioma in a 36-year-old woman was accompanied by elevated serum levels of human chorionic gonadotropin—β subunit (β-HCG), which returned to normal after removal of the tumor. Light microscopy examination demonstrated a transitional meningioma. Immunohistochemical analysis revealed that the tumor cells had a positive reaction for β-HCG. This case illustrates the possibility that meningioma may be associated with clinically detectable secretion of β-HCG. To the authors' knowledge, this is the first case in which meningioma has been shown to secrete β-HCG. The authors believe

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18

Posecion, Geraldine C., та Veronica M. Deniega. "Correlation of uterine artery Doppler flow velocimetry and β-human chorionic gonadotropin levels during postmolar evacuation surveillance: A pilot study in a tertiary hospital". Philippine Journal of Obstetrics and Gynecology 48, № 1 (2024): 22–30. http://dx.doi.org/10.4103/pjog.pjog_66_23.

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BACKGROUND: During postmolar evacuation surveillance, beta-human chorionic gonadotropin (β-hCG) regression levels can predict invasive disease while Doppler ultrasound can assess in vivo tumor neovascularization and quantify uterine blood supply. As an ancillary tool to β-hCG monitoring, ultrasound can detect the early presence of viable trophoblastic tissues and identify patients at risk of developing postmolar gestational trophoblastic Neoplasia (PMGTN). OBJECTIVE: The objective of this study was to correlate uterine artery Doppler ultrasound with β-hCG levels during pre- and postmolar evacu

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Cole, Laurence A., Jaime M. Sutton, Trefor N. Higgins, and George S. Cembrowski. "Between-Method Variation in Human Chorionic Gonadotropin Test Results." Clinical Chemistry 50, no. 5 (2004): 874–82. http://dx.doi.org/10.1373/clinchem.2003.026989.

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Abstract Background: Results on sera and calibrators vary 1.4- to 2.3-fold among commercial human chorionic gonadotropin (hCG) assays. The relative contributions of calibrators, standards, hCG charge isoforms, and major structural variants to this variation have not been quantified. Methods: Purified hCG was separated by isoelectric focusing into four fractions with pI ranges of 3–4, 4–5, 5–6, and 6–7. These four fractions together with pure hCG, hyperglycosylated hCG, hCG β-subunit (hCGb), nicked hCG, and hCGb core fragment (hCGbcf) were tested in nine commonly used commercial serum assays fo

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McChesney, Ruth, Allen J. Wilcox, John F. O'Connor та ін. "Intact HCG, free HCG β subunit and HCG β core fragment: longitudinal patterns in urine during early pregnancy". Human Reproduction 20, № 4 (2005): 928–35. http://dx.doi.org/10.1093/humrep/deh702.

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Kurniawan, Agung, Shofwal Widad та Diah Rumekti Hadiati. "Hubungan Kadar β-hCG 12 Hari Pasca Transfer Embryo dengan Luaran Kehamilan". Jurnal Kesehatan Reproduksi 7, № 1 (2020): 13. http://dx.doi.org/10.22146/jkr.53479.

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Latar Belakang: Subfertilitas merupakan salah satu permasalahan yang sering ditemukan di era modern ini. Berbagai metode ditemukan dan digunakan untuk meningkatkan angka keberhasilan reproduksi pada perempuan. Teknologi reproduksi berbantu memiliki risiko terjadinya keguguran dan kehamilan ektopik. Kadar serum β-hCG 12 hari pasca transfer embryo memiliki peranan penting dalam prediksi luaran kehamilan.Tujuan: Untuk memprediksi luaran kehamilan, sensitivitas, spesifisitas serta nilai ambang kadar β-hCG 12 hari pasca transfer embryo.Metode: Penelitian menggunakan rancangan penelitian observasion

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Hudelist, Gernot, Ambros Huber, Martin Knoefler та ін. "β-HCG/LH Receptor (β-HCG/LH-R) Expression in Eutopic Endometrium and Endometriotic Implants: Evidence for β-HCG Sensitivity of Endometriosis". Reproductive Sciences 15, № 6 (2008): 543–51. http://dx.doi.org/10.1177/1933719108316907.

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Xia, H., J. Huang, T.-M. Chen та D. Puett. "Lysine residues 2 and 104 of the human chorionic gonadotrophin β subunit influence receptor binding". Journal of Molecular Endocrinology 10, № 3 (1993): 337–43. http://dx.doi.org/10.1677/jme.0.0100337.

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ABSTRACT Human chorionic gonadotrophin (hCG), like other members of the glycoprotein hormone family, contains a common α subunit and a hormone-specific β subunit. The latter is a 145 amino acid residue polypeptide with six sites of glycosylation. Positions 2 and 104 are occupied by basic amino acid residues in the 12 known amino acid sequences of mammalian β subunits from CG and LH, a related gonadotrophin that acts through the same receptor. Lysine residues are found in both these positions in hCG-β. Using site-directed mutagenesis, each of these two lysines in hCG-β was replaced with glutami

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Kulkarni, Jayshree, Sukesh Kathpalia, Swapnali Sansare, and Manasvi Milind Kulkarni. "Early prediction of gestational hypertension using β-hCG Levels: A cross-sectional study in a tertiary care hospital of Maharashtra, India." Indian Journal of Obstetrics and Gynecology Research 12, no. 1 (2025): 16–20. https://doi.org/10.18231/j.ijogr.2025.003.

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Pregnancy-Induced Hypertension (PIH) is a significant complication affecting pregnant women, with potential severe outcomes for both mother and fetus. This study investigates the relationship between serum β-hCG levels and the risk of PIH, aiming to determine if elevated β-hCG can serve as an early indicator for PIH.A cross-sectional study was conducted on 100 pregnant women aged 20 to 40 years at 14 to 19 weeks of gestation. Participants were categorized based on age, socioeconomic status, and occupation. Blood pressure measurements and β-hCG levels were recorded and analyzed. The mean age wa

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Thomas, C. M. G., M. F. G. Segers та P. C. Whoux. "Comparison of the Analytical Characteristics and Clinical Usefulness in Tumour Monitoring of Fifteen hCG(-β) Immunoassay Kits". Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 22, № 3 (1985): 236–46. http://dx.doi.org/10.1177/000456328502200305.

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Fifteen immunoassay kits for serum hCG(-β) measurements have been compared for their analytical characteristics and clinical usefulness in tumour monitoring. Three out of 13 radioimmunoassays and two sandwich hCG immunoassays represent the ‘one-component’ techniques for intact hCG detection since they are based on antiserum raised against intact hCG. Within this group, method-comparison slopes ranged between 0·149 and 0·374. The remaining 10 radioimmunoassays all apply antiserum against hCG-β and are designated ‘two (or more)–component’ assays since they detect both intact hCG and the free β-s

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Cao, H., Z. M. Lei та Ch V. Rao. "Consequences of antisense human chorionic gonadotrophin-α subunit cDNA expression in human choriocarcinoma JAR cells". Journal of Molecular Endocrinology 14, № 3 (1995): 337–47. http://dx.doi.org/10.1677/jme.0.0140337.

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ABSTRACT The biosynthesis of human chorionic gonadotrophin (hCG) is a hallmark endocrine function of human choriocarcinoma cells. The present study investigated the consequences of greatly diminishing this synthesis in JAR cells by stably transfecting them with pRSV-antisense hCG-α cDNA expression vector. The vector directs the synthesis of antisense hCG-α subunit mRNA which would then bind to sense hCG-α subunit mRNA, thus blocking its translation and consequently dimer hCG protein synthesis. The transfection with pRSV-antisense hCG-α cDNA resulted in a dramatic decrease in hCG secretion as c

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Iles, Ray K., Mohammed K. Javid, Lionel K. Gunn та Tim Chard. "Cross-Reaction with Luteinizing Hormone β-Core Is Responsible for the Age-dependent Increase of Immunoreactive β-Core Fragment of Human Chorionic Gonadotropin in Women with Nonmalignant Conditions". Clinical Chemistry 45, № 4 (1999): 532–38. http://dx.doi.org/10.1093/clinchem/45.4.532.

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Abstract Background: The β-core fragment of human chorionic gonadotropin (hCGβcf), also termed “β-core” and urinary gonadotropin peptide (UGP), has been reported to be present in the urine of healthy women and to increase in concentration after menopause. This could reflect cross-reaction with the equivalent metabolite of luteinizing hormone (LH), the β-LH-core. Methods: We measured immunoreactive LH, hCG, free α-subunit, and free β-subunit hCG (hCGβ), as well as β-core, using the S504 RIA and Triton UGP enzyme immunoassay in 274 urine samples from women with nonmalignant gynecological conditi

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Kumari, Archana, and Vahini M. "Association between maternal serum beta human chorionic gonadotropin levels and hypertensive disorders of pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 8 (2020): 3157. http://dx.doi.org/10.18203/2320-1770.ijrcog20203052.

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Background: A major challenge in obstetrics is early identification of hypertensive disorders of pregnancy (HDP). This study was performed to determine the association between elevated maternal serum β-hCG levels and HDP, the correlation between serum β-hCG level and severity of preeclampsia and to determine the value of serum β-hCG level as a diagnostic marker for early diagnosis of HDP.Methods: This was a hospital based observational study conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi on 375 pregnant women with period of gestation mo

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Bassam, Amira Mohamed, Yousra Raafat, Ahmed Mahmoud Abd Al-Aziz та Rasha Ramadan Mostafa. "Immunohistochemical Expression of “HCG-β” in Colorectal Carcinoma". Open Access Macedonian Journal of Medical Sciences 9, A (2021): 789–97. http://dx.doi.org/10.3889/oamjms.2021.6854.

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BACKGROUND: Tumor budding is associated with adverse histology and is a predictor of lymph node metastasis. Human chorionic gonadotropin-beta (hCG-β) expression in non-trophoblastic tumors has been associated with aggressive behavior. AIM: Evaluation of tumor budding and hCG-β _immunohistochemical expression in colorectal carcinoma (CRC), and correlation of their expression with various clinicopathological parameters. MATERIALS AND METHODS: Immunohistochemical staining for hCG-β _was performed on paraffin-embedded sections of 60 cases of CRC. Tumors with cytoplasmic or membranous staining of m

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Rajuddin, Rajuddin, Riska Firda Rini та Nurjannah Nurjannah. "HUBUNGAN KADAR PROGESTERON DAN β-HCG DENGAN ABORTUS PADA KEHAMILAN ≤ 12 MINGGU DI KLINIK RASI BANDA ACEH". AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh 2, № 2 (2018): 19. http://dx.doi.org/10.29103/averrous.v2i2.409.

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AbstrakProgesteron dan β-hCG sangat berperan penting untuk mempertahankan kehamilan, terutama pada awal kehamilan sehingga rendahnya kadar progesteron dan kadar β-hCG diduga dapat menyebabkan terjadinya abortus. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kadar progesteron dan kadar β-hCG dengan kejadian abortus. Rancangan penelitian yang digunakan dalam penelitian ini adalah kohort retrospektif. Subjek penelitian terdiri atas 70 orang ibu hamil yang berobat ke praktik Dokter Spesialis Kandungan dan Kebidanan Konsultan Fertilisasi dan Endokrinologi Reproduksi di Klinik R

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Sanchez, Natalia Gabriela, Andrew E. Horvai, Emanuela Zacco, and Varun Monga. "Human chorionic gonadotropin-secreting osteosarcoma." BMJ Case Reports 18, no. 1 (2025): e261810. https://doi.org/10.1136/bcr-2024-261810.

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Secretion of beta human chorionic gonadotropin (β-hCG) is a rare, recently recognised paraneoplastic syndrome. Herein, we present a case of a woman in her 30s with right femur conventional high-grade osteosarcoma and a positive screening urine pregnancy test. Subsequent workup failed to reveal an intrauterine or extrauterine pregnancy. Rather, pathology and gene expression studies confirmed serum β-hCG production by osteosarcoma cells. Though the prognostic implications of β-hCG expression are unclear, β-hCG may be a useful surveillance marker to monitor disease progression or recurrence.

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Blackwell, Conner, Shian McLeish, David Iglesias, and Shannon D. Armbruster. "Dysgerminoma Masquerading as Gestational Trophoblastic Neoplasia." Case Reports in Obstetrics and Gynecology 2023 (February 8, 2023): 1–4. http://dx.doi.org/10.1155/2023/1901858.

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Background. Persistent elevation in beta-human chorionic gonadotropin (β-hCG) following a pregnancy is concerning for gestational trophoblastic neoplasia (GTN). However, the differential diagnosis should remain broad during the evaluation process. Case. A 34-year-old G3P3 presented with elevated β-hCG four months after cesarean delivery with bilateral tubal ligation. The patient was treated with methotrexate for a presumed new ectopic pregnancy. Due to persistent β-hCG elevation, she received actinomycin-D for GTN treatment. After completing chemotherapy, her β-hCG increased. The patient under

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McNamee, David. "β-hCG inhibits Kaposi's sarcoma". Lancet 345, № 8958 (1995): 1169. http://dx.doi.org/10.1016/s0140-6736(95)90998-2.

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Wehmann, R. E., D. L. Blithe, A. H. Akar та B. C. Nisula. "β-Core fragments are contaminants of the World Health Organization Reference Preparations of human choriogonadotrophin and its α-subunit". Journal of Endocrinology 117, № 1 (1988): 147–52. http://dx.doi.org/10.1677/joe.0.1170147.

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ABSTRACT Highly purified preparations of human choriogonadotrophin (hCG), hCGα and hCGβ, including those preparations which are being distributed by the World Health Organization as International Standards, cross-reacted in a new radioimmunoassay with increased relative specificity for the β-core fragment of hCG. A major portion of the β-core immunoreactivity in the hCG and hCGα preparations eluted from Sephadex G-100 in a position (approximate apparent molecular size 15 000–18 000) corresponding to that of purified β-core fragment prepared from pregnancy urine. However, in the case of hCGβ-su

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Cole, Laurence A. "Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites." Clinical Chemistry 43, no. 12 (1997): 2233–43. http://dx.doi.org/10.1093/clinchem/43.12.2233.

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Abstract Multiple hCG-related molecules are present in pregnancy serum and urine samples. These include nonnicked hCG (the hormone), nicked hCG, hyper- and hypoglycosylated hCG, hCG missing the C-terminal extension, free α-subunit, large free α-subunit, free β-subunit, nicked free β-subunit, and β-core fragment. Over 100 immunoassays are sold for quantifying hCG-related molecules in serum or urine. Each measures nonnicked hCG and one of seven combinations of the other hCG-related molecules. This is the source of interassay discordance in hCG determinations. Whereas minor variations are noted i

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Gupta, Ritika, Priyanka Mukherjee, Harpreet Kaur та Sahil Singhal. "Role of cervicovaginal β-hCG in prediction of preterm delivery: a prospective observational study". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, № 9 (2020): 3677. http://dx.doi.org/10.18203/2320-1770.ijrcog20203839.

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Background: The World Health Organization (WHO) factsheet revealed that 15 million babies are born too early every year and almost 1 million children die each year due to complications of preterm birth. The objective of this study was to determine whether cervicovaginal β-hCG level can be used as predictor of preterm delivery in asymptomatic high-risk pregnant women at 24-34 weeks gestation age.Methods: This was prospective observational study. Total 134 asymptomatic pregnant women were taken for study who had at least one risk factor for preterm delivery at 24-34 weeks gestation age. Cervicov

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Sah, Sanjay Kumar, Pravin Shah, and Ang Dali Sherpa. "False Low Beta-hCG in a Complete Hydatidiform Molar Pregnancy: A Case of Hook Effect." Med Phoenix 9, no. 1 (2024): 41–43. http://dx.doi.org/10.3126/medphoenix.v9i1.67256.

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Introduction: Hydatidiform molar pregnancy presents as a proliferative disorder of trophoblastic cells. Complete hydatidiform molar pregnancy presents typically with abnormally high levels of beta human chorionic gonadotropin (β-hCG). The high level of β-hCG is taken as a marker in its diagnosis and follows up. However, many a times very high levels of β-hCG may be associated with falsely low or negative β-hCG levels because of “Hook effect”. The hook effect occurs with extremely high levels of β-hCG, saturating detection antibodies, leading to falsely low laboratory results. If unrecognized,

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Gondo, Harry K., and Elizabeth Haryanti. "Pengaruh Spirulina terhadap Kadar beta hCG Tikus Bunting yang Diinduksi Interleukin-6 (Studi Bahan Biologis Tersimpan)." Jurnal Ilmiah Kedokteran Wijaya Kusuma 10, no. 1 (2021): 84. http://dx.doi.org/10.30742/jikw.v10i1.1067.

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Preeclampsia is multisystem specific disorder in pregnancy. Preeclampsia characterized by increased cytokine Interleukin-6 and β hCG (human Chorionic Gonadotropin). Spirulina is green-blue alga contain antioxidant, vitamin, mineral. Spirulina has a potential effect as antiinflammation. The aim of this research was to know effect of spirulina to repair trophoblast at β hCG level of pregnant rats with preeclampsia condition (biology material collecting). The type of this research is an experimental laboratory with post-test only control group design. Preeclampsia models induced by Interleukin-6.

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Komarnicki, Paweł, Paweł Gut, Maja Cieślewicz та ін. "Serum β-hCG as a Biomarker in Pancreatic Neuroendocrine Tumors: Rethinking Single-Analyte Approach". Cancers 16, № 11 (2024): 2060. http://dx.doi.org/10.3390/cancers16112060.

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Despite recent advances, neuroendocrine tumors (NETs) remain a challenging topic, due to their diversity and the lack of suitable biomarkers. Multianalyte assays and the shift to an omics-based approach improve on the conventional single-analyte strategy, albeit with their own drawbacks. We explored the potential of serum β-hCG as a biomarker for NETs and discussed its role in disease monitoring. We recruited 40 patients with non-functioning pancreatic NETs, all with liver metastases. Serum β-hCG concentrations were measured at 3-month intervals over 48 months. We performed a comparative and a

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Behtash, N., F. Ghaemmaghami, H. Honar та ін. "Is normal β-hCG regression curve helpful in the diagnosis of persistent trophoblastic disease?" International Journal of Gynecologic Cancer 14, № 5 (2004): 980–83. http://dx.doi.org/10.1136/ijgc-00009577-200409000-00035.

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ObjectiveThe aim of this study was to evaluate the probable usefulness of normal β-human chorionic gonadotropin (β-hCG) regression curve in the diagnosis of persistent trophoblastic disease (PTD).MethodsA log-value regression curve was developed from the means and 95% confidence limits of serial weekly serum β-hCG titers of 43 patients with uneventful complete hydatidiform moles and 14 patients, who were previously confirmed as PTD.ResultsAll 14 PTD patients (100%) had abnormal values, beyond normal range, within 4 weeks. β-hCG was in its upper values, compared to normal regression curve at 2.

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Vischer, Henry F., Joke C. M. Granneman, and Jan Bogerd. "Opposite Contribution of Two Ligand-Selective Determinants in the N-Terminal Hormone-Binding Exodomain of Human Gonadotropin Receptors." Molecular Endocrinology 17, no. 10 (2003): 1972–81. http://dx.doi.org/10.1210/me.2003-0172.

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Abstract The nine leucine-rich repeat-containing exodomains of the human FSH receptor (hFSH-R) and the human LH/chorionic gonadotropin receptor (hLH-R) harbor molecular determinants that allow the mutually exclusive binding of human FSH (hFSH) and human LH (hLH)/human chorionic gonadotropin (hCG) when these hormones are present in physiological concentrations. Previously, we have shown that the β-strands of hLH-R leucine-rich repeats 3 and 6 can confer full hCG/hLH responsiveness and binding when simultaneously introduced into a hFSH-R background without affecting the receptor’s responsiveness

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Berger, P., R. Klieber, W. Panmoung, S. Madersbacher, H. Wolf, and G. Wick. "Monoclonal antibodies against the free subunits of human chorionic gonadotrophin." Journal of Endocrinology 125, no. 2 (1990): 301–9. http://dx.doi.org/10.1677/joe.0.1250301.

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ABSTRACT Discordant results on body fluid levels of human chorionic gonadotrophin (hCG) free α- and β-subunits under physiological and pathophysiological conditions, prompted us to raise a total of 260 monoclonal antibodies (MCA) against free hCG-α, free hCG-β, holo-hCG, human follicle-stimulating hormone and bovine luteinizing hormone; 153 MCA recognizing the human α-subunit and 28 reacting with hCG-β were extensively analysed for their intra- and interspecies cross-reactivity with homologous hormones, and for the compatibility of epitopes recognized by them. The immunological topography of f

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Tallen, Gesche, Susanne Fehr, Wolfgang Saeger, Holger Uhlig та Dieter K. Lüdecke. "Detection of growth hormone, prolactin and human β-chorionic gonadotropin mRNA in growth hormone-secreting pituitary adenomas and in prolactin-secreting pituitary adenomas by in situ hybridization using a non-isotopic detection method". Acta Endocrinologica 128, № 5 (1993): 411–17. http://dx.doi.org/10.1530/acta.0.1280411.

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A non-isotopic in situ hybridization method with digoxigenin-labelled probes was used to examine growth hormone (GH), prolactin (PRL) and human β-chorionic gonadotropin (β-hCG(LH)) gene expression in 63 pituitary tumours in acromegaly and 20 adenomas in hyperprolactinaemia. hCG and LH were detected simultaneously because of the extensive homology (more than 90%) of their mRNA sequences (1). A comparison with former results obtained with 35S-labelled probes shows the value of the easier and faster non-isotopic method. Additionally, immunohistochemical data are included to give even more evidenc

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Póvoa, Ana, Pedro Xavier, Alexandra Matias та Isaac Blickstein. "First trimester β-hCG and estradiol levels in singleton and twin pregnancies after assisted reproduction". Journal of Perinatal Medicine 46, № 8 (2018): 853–56. http://dx.doi.org/10.1515/jpm-2017-0132.

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Abstract Objective To compare levels of β-hCG and estradiol collected during the first trimester in singleton and twin pregnancies following assisted reproduction technologies (ART). Methods We prospectively evaluated 50 singleton and 47 dichorionic twin pregnancies that eventually ended in live births. Patients were recruited from a single ART center with standard treatment protocols followed by fresh embryo transfers. Hormone measurements were performed within a narrow gestational age range and analyzed in a single laboratory thus minimizing inter- and intra-assay variability. We measured se

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Iles, R. K., and T. Chard. "Immunochemical analysis of the human chorionic gonadotrophin-like material secreted by 'normal' and neoplastic urothelial cells." Journal of Molecular Endocrinology 2, no. 2 (1989): 107–12. http://dx.doi.org/10.1677/jme.0.0020107.

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ABSTRACT Material with the immunochemical characteristics of human chorionic gonadotrophin (hCG) is produced by bladder tumour cells in vitro and in vivo. In order to characterize this material further, media were collected from 17 cell cultures (three choriocarcinomas, seven bladder carcinomas and seven 'normal' urothelium). The hCG-like material was compared with pregnancy hCG and purified α- and β-subunits by specific radioimmunoassays. Media were also submitted to affinity chromatography and the fractions further analysed by SDS-PAGE and Western blotting. It was shown that both the neoplas

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Davis, Amenda Ann, Kusum Lata, Akshita Panwar, and Alka Kriplani. "Unexpected rupture of an expectantly managed tubal ectopic pregnancy: a reminder for enhanced diligence." BMJ Case Reports 12, no. 12 (2019): e230876. http://dx.doi.org/10.1136/bcr-2019-230876.

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Expectant management of tubal ectopic pregnancies is a feasible and possibly preferable method of management in asymptomatic women with low serum β-human chorionic gonadotropin (hCG). This involves serial monitoring of β-hCG until negative, after which it is deemed as spontaneously resolved ectopic pregnancy. We describe a case of tubal ectopic pregnancy which was expectantly managed with an initial β-hCG of 585 mIU/mL until undetectable. This patient presented with ruptured ectopic pregnancy 8 weeks after the original diagnosis, at the level of 5 mIU/mL. This highlights the importance of clos

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Akar, A. H., G. Gervasi, C. Blacker, R. E. Wehmann, D. L. Blithe та B. C. Nisula. "Human chorionic gonadotrophin-like and β-core-like materials in postmenopausal urine". Journal of Endocrinology 125, № 3 (1990): 477–84. http://dx.doi.org/10.1677/joe.0.1250477.

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ABSTRACT In addition to human chorionic gonadotrophin (hCG), the urine of pregnant women contains a small molecular weight form of the hCG-β subunit known as β-core. Human CG-like material has been described in tissues, serum and urine of normal man, particularly in postmenopausal women. We examined different urine preparations from postmenopausal women to determine whether β-core-like material, as well as hCG-like material, could be detected. We studied an acetone extract of a pool of 11 litres of postmenopausal urine, three different commercial preparations of human menopausal gonadotrophins

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Ozer, Gonul. "Initial β-hCG levels and 2-day-later increase rates effectively predict pregnancy outcomes in single blastocyst transfer in frozen-thawed or fresh cycles: A retrospective cohort study". Medicine 102, № 42 (2023): e35605. http://dx.doi.org/10.1097/md.0000000000035605.

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To investigate whether the initial beta-human chorionic gonadotropin (β-hCG) levels and their rate of increase differ after single fresh and frozen blastocyst transfers, and whether these values effectively predict pregnancy outcomes. This retrospective cohort study was conducted at the Sisli Memorial Hospital, assisted reproductive technology, and Reproductive Genetics Center in Istanbul, Turkey, between January 2016 and January 2022. Three thousand two hundred thirty-eight single blastocyst transfers with positive pregnancy test results were evaluated. Of these, 738 were fresh transfer cycle

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Pawar, Preeti, Ritu Goyal, Harvinder Kaur та Neelam Singal. "Study of significance of elevated maternal serum β-human chorionic gonadotropin (β-hCG) level in 16 to 20 weeks pregnant women as predictor of hypertensive disorder of pregnancy". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, № 11 (2018): 4721. http://dx.doi.org/10.18203/2320-1770.ijrcog20184537.

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Background: Hypertensive disorder of pregnancy affects both mother and fetus, leading their high morbidity and mortality and a major killer of women in developing country. The etiologic of preeclampsia is still not clear. It seems that placenta plays main role in path-physiology of preeclampsia, but there is strict relationship between hypertensive disorder of pregnancy and elevated β-hCG level, indicating there should be an abnormal placental secretary function in patients with severe preeclampsia.Methods: 245 patients were recruited from our institute (OPD) and Prospective analytical study w

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Kumari, Shilpa, and Gunjan Chaudhary. "Correlation of levels of early second trimester beta-human chorionic gonadotropin levels with severity of preeclampsia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 12 (2022): 3340. http://dx.doi.org/10.18203/2320-1770.ijrcog20223127.

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Background: Hypertensive disorders in pregnancy remains a leading cause of maternal morbidity and mortality all over the world as per World Health Organization (WHO), affecting 5-10% of all pregnant women. Screening women at an early stage and preventing complications are corner stone in the management of pre-eclampsia. Several studies have proven the reliability of beta-human chorionic gonadotropin (β-hCG) as predictor of preeclampsia. In this study we aim to find the correlation of increasing levels of β-hCG with severity of preeclampsia.Methods: In this study serum β-hCG estimation was done

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