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Artykuły w czasopismach na temat „2-diethylhexyl phthalate”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Neier, Kari, Drew Cheatham, Leah D. Bedrosian, Brigid E. Gregg, Peter X. K. Song, and Dana C. Dolinoy. "Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice." Endocrinology 160, no. 7 (2019): 1613–30. http://dx.doi.org/10.1210/en.2019-00287.

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Abstract Developmental exposures to phthalates are suspected to contribute to risk of metabolic syndrome. However, findings from human studies are inconsistent, and long-term metabolic impacts of early-life phthalate and phthalate mixture exposures are not fully understood. Furthermore, most animal studies investigating metabolic impacts of developmental phthalate exposures have focused on diethylhexyl phthalate (DEHP), whereas newer phthalates, such as diisononyl phthalate (DINP), are understudied. We used a longitudinal mouse model to evaluate long-term metabolic impacts of perinatal exposur

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Reeves, Katherine W., Mary Díaz Santana, JoAnn E. Manson, et al. "Urinary Phthalate Biomarker Concentrations and Postmenopausal Breast Cancer Risk." JNCI: Journal of the National Cancer Institute 111, no. 10 (2019): 1059–67. http://dx.doi.org/10.1093/jnci/djz002.

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Abstract Background Growing laboratory and animal model evidence supports the potentially carcinogenic effects of some phthalates, chemicals used as plasticizers in a wide variety of consumer products, including cosmetics, medications, and vinyl flooring. However, prospective data on whether phthalates are associated with human breast cancer risk are lacking. Methods We conducted a nested case-control study within the Women’s Health Initiative (WHI) prospective cohort (n = 419 invasive case subjects and 838 control subjects). Control subjects were matched 2:1 to case subjects on age, enrollmen

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Shaz, Beth H., Kathleen Grima, and Christopher D. Hillyer. "2-(Diethylhexyl)phthalate in blood bags: is this a public health issue?" Transfusion 51, no. 11 (2011): 2510–17. http://dx.doi.org/10.1111/j.1537-2995.2011.03164.x.

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Beg, Mohd Amin, and Ishfaq Ahmad Sheikh. "Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites." Toxics 8, no. 4 (2020): 115. http://dx.doi.org/10.3390/toxics8040115.

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Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chloride plastics for household and commercial use. DEHP is a ubiquitous ecocontaminant and causes developmental and reproductive problems in children and adults. After exposure, DEHP is metabolized by endogenous hydrolysis and oxidation into the primary metabolite, mono-(2-ethylhexyl) phthalate (MEHP), and the secondary metabolites, mono-(2-ethyl-5-hydroxhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl) phthalate (5-cx-MEPP), and mono-[(2-car

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Reale, Elena, Nancy B. Hopf, Florian Breider, et al. "Repeated Human Exposure to Semivolatile Organic Compounds by Inhalation: Novel Protocol for a Nonrandomized Study." JMIR Research Protocols 12 (October 13, 2023): e51020. http://dx.doi.org/10.2196/51020.

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Background Semivolatile organic compounds (SVOCs) comprise several different chemical families used mainly as additives in many everyday products. SVOCs can be released into the air as aerosols and deposit on particulate matter during use by dispersion, evaporation, or abrasion. Phthalates are SVOCs of growing concern due to their endocrine-disrupting effects. Human data on the absorption, distribution, metabolism, and excretion (ADME) of these compounds upon inhalation are almost nonexistent. Objective The goal of this study is to develop a method for repeated inhalation exposures to SVOCs to

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6

Laskey, J. W., and E. Berman. "Steroidogenic assessment using ovary culture in cycling rats: Effects of bis (2-diethylhexyl) phthalate on ovarian steroid production." Reproductive Toxicology 7, no. 1 (1993): 25–33. http://dx.doi.org/10.1016/0890-6238(93)90006-s.

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Lin, Tien-Jen, Chi-Chang Huang, Mon-Chien Lee, et al. "Effects of Lactobacillus salivarius ssp. salicinius SA-03 Supplementation on Reversing Phthalate-Induced Asthma in Mice." Nutrients 16, no. 8 (2024): 1160. http://dx.doi.org/10.3390/nu16081160.

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Probiotics may protect against asthma. We want to investigate whether probiotics can reverse the adverse effects of phthalate exposure on asthma. We selected the female offspring of BALB/c mice, born from pregnant female mice fed with diethylhexyl phthalate (DEHP). They were continuously administrated DEHP and Lactobacillus salivarius ssp. salicinius SA-03 when they were 5 weeks old, and ovalbumin (OVA) for asthma induction started at 6 weeks for 32 days. The mice were divided into four groups (n = 6/group): 1. control group (C), 2. OVA/DEHP group (OD), 3. OVA/DEHP/probiotics low-dose group (O

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8

Brady, P. S., and L. J. Brady. "Hepatic carnitine palmitoyltransferase turnover and translation rates in fed, starved, streptozotocin-diabetic and diethylhexyl phthalate-treated rats." Biochemical Journal 246, no. 3 (1987): 641–49. http://dx.doi.org/10.1042/bj2460641.

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Hepatic carnitine palmitoyltransferase (CPT) turnover was studied in control and in non-ketotic hyperglycaemic streptozotocin-diabetic rats. The degradation constant (kd) and half-life (t1/2) did not appear to be altered by mild diabetes. The hepatic CPT (micrograms/g of liver) was not increased by the mild, non-ketotic, diabetes. However, the total hepatic CPT (micrograms/liver) was 37% greater in the diabetic animals, owing to the increased liver weight. This resulted from a 40% increase in the synthesis constant (ks). Hepatic CPT activity (total detergent-solubilized) and translation rates

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Stein, T. Peter, Margaret D. Schluter, Robert A. Steer, and Xue Ming. "Bisphenol-A and phthalate metabolism in children with neurodevelopmental disorders." PLOS ONE 18, no. 9 (2023): e0289841. http://dx.doi.org/10.1371/journal.pone.0289841.

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Background The etiology of autism spectrum (ASD) and Attention Deficit/Hyperactivity (ADHD) disorders are multifactorial. Epidemiological studies have shown associations with environmental pollutants, such as plasticizers. This study focused on two of these compounds, the Bisphenol-A (BPA) and Diethylhexyl Phthalate (DEHP). The major pathway for BPA and DEHP excretion is via glucuronidation. Glucuronidation makes insoluble substances more water-soluble allowing for their subsequent elimination in urine. Hypothesis Detoxification of these two plasticizers is compromised in children with ASD and

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10

Mozharivska, A. A. "Modern approaches to infusion therapy in pediatrics and chemotherapy." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 215–17. http://dx.doi.org/10.32902/2663-0338-2020-3.2-215-217.

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Background. Systems for intravenous administration of blood products and drugs are divided into the systems for transfusion (pore diameter – 114-200 μm) and systems for infusion (pore diameter – 15-75 μm). Gravity delivery systems consist of a drip chamber, an infusion rate regulator, a needle connector, a system tube, an injection needle, and a system fixation patch. Objective. To describe modern approaches and devices for infusion therapy. Materials and methods. Analysis of the literature on this issue. Results and discussion. If the needle is integrated into a drip chamber

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11

Story, D. A., J. Leeder, P. Cullis, and R. Bellomo. "Biologically Active Contaminants of Intravenous Saline in PVC Packaging: Australasian, European, and North American Samples." Anaesthesia and Intensive Care 33, no. 1 (2005): 78–81. http://dx.doi.org/10.1177/0310057x0503300113.

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We have previously found evidence of contaminants in 0.9% saline packaged in polyvinyl chloride (PVC) for clinical use. For this current study we asked two questions: (1) what are the organic chemical contaminants in solutions packaged in PVC? and (2) do the contaminants vary in bags manufactured in different countries? We studied samples of 0.9% saline packaged in PVC from Australasia, Europe, and North America. We analysed the saline solutions with high-resolution capillary gas chromatography – mass spectrometry. Components of the Australasian and European bags were also analysed using therm

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12

Brady, P. S., K. A. Marine, L. J. Brady, and R. R. Ramsay. "Co-ordinate induction of hepatic mitochondrial and peroxisomal carnitine acyltransferase synthesis by diet and drugs." Biochemical Journal 260, no. 1 (1989): 93–100. http://dx.doi.org/10.1042/bj2600093.

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The present studies examined the effect of agents that induce peroxisomal and mitochondrial beta-oxidation on hepatic mitochondrial carnitine palmitoyltransferase (CPT) and peroxisomal carnitine acyltransferase [CPTs of Ramsay (1988) Biochem. J. 249, 239-245; COT of Farrell & Bieber (1983) Arch. Biochem. Biophys. 222, 123-132 and Miyazawa, Ozasa, Osumi & Hashimoto (1983) J. Biochem. 94, 529-542]. In the first studies, high fat diets containing corn oil or fish oil were used to induce peroxisomal and mitochondrial enzymes. Rats were fed one of three diets for 4 weeks: (1) low fat, with

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13

Fei, Fei, Zhongwei Liu, Qiang Chen, and Fuping Liu. "Kinetic Migration of Diethylhexyl Phthalate in Functional PVC Films." Plasma Science and Technology 14, no. 2 (2012): 152–56. http://dx.doi.org/10.1088/1009-0630/14/2/13.

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14

Kim, Soo Jin, Jun-Yeon Lee, Ju-Hee Hong, and Seunghon Ham. "Characteristics of Hazardous Substances Extracted from Laundry Water for Fire Protection Suit Exposed to Fire." Water 14, no. 15 (2022): 2383. http://dx.doi.org/10.3390/w14152383.

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(1) Background: It is well known that various toxic substances, including carcinogens, are generated at the fire scenes, so it is very important for firefighters to wear comprehensive personal protective equipment. The extent of the type and amount of harmful substances contained in the washing water of fire protection suits (FPS) exposed to fire scenes have not yet been confirmed. The purpose of this study is to evaluate the characteristics of harmful substances contained in wash water extracted from FPSs exposed to fire. (2) Methods: The study design was a simulation-based experimental study

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FAOUZI, M., T. DINE, M. LUYCKX, et al. "Leaching of diethylhexyl phthalate from PVC bags into intravenous teniposide solution." International Journal of Pharmaceutics 105, no. 1 (1994): 89–93. http://dx.doi.org/10.1016/0378-5173(94)90240-2.

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Shioda, T., and M. Wakabayashi. "Evaluation of reproductivity of medaka (Oryzias latipes) exposed to chemicals using a 2-week reproduction test." Water Science and Technology 42, no. 7-8 (2000): 53–60. http://dx.doi.org/10.2166/wst.2000.0552.

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Effects of endocrine disrupting chemicals on reproductive ability of medaka (Oryzias latipes) were investigated. Exposure of male medaka to estrogenic chemicals such as 17β-estradiol (E2), p-nonylphenol (NP), 4-t-butylphenol (BP) and bisphenol-A (BPA) caused a decrease in the numbers of eggs hatched rather than those of eggs spawned, which seemed to be affected by estrogen-like effects of these chemicals. Exposure of female medaka to E2 and NP reduced the numbers of eggs spawned rather than those of eggs hatched. The concentrations at which reproductivity of female decreased (E2:0.1 nmol/L, NP

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Zaritskaya, Ekaterina V., Pavel A. Ganichev, Olga L. Markova, Alena Yu Mikheeva, and Gennady B. Yeremin. "Diethylhexyl phthalate as a current problem of hygienic safety of packaging and packaged drinking water." Hygiene and sanitation 101, no. 1 (2022): 30–34. http://dx.doi.org/10.47470/0016-9900-2022-101-1-30-34.

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Introduction. The chemical safety of packaged drinking water is influenced by many factors, including the quality of packaging materials. The chemical components included in the packaging can migrate into drinking water and have a negative impact on human health. The most common types of packaging for drinking water are polyethylene terephthalate (PET, PET) and polycarbonate (PC) bottles. In the production of polymers, to soften and increase the flexibility of the finished product, special substances are added to the material - plasticisers, including dialkyl or alkyl aryl esters of orthophtha

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18

Cheng, Shun-Feng, Ling Li, Bo Li, et al. "Low-dose diethylhexyl phthalate exposure does not impair the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in mouse mammary glands." Molecular & Cellular Toxicology 14, no. 2 (2018): 143–53. http://dx.doi.org/10.1007/s13273-018-0016-2.

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19

Neier, Kari, Luke Montrose, Kathleen Chen, et al. "Short- and long-term effects of perinatal phthalate exposures on metabolic pathways in the mouse liver." Environmental Epigenetics 6, no. 1 (2020). http://dx.doi.org/10.1093/eep/dvaa017.

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Abstract Phthalates have been demonstrated to interfere with metabolism, presumably by interacting with peroxisome proliferator-activated receptors (PPARs). However, mechanisms linking developmental phthalate exposures to long-term metabolic effects have not yet been elucidated. We investigated the hypothesis that developmental phthalate exposure has long-lasting impacts on PPAR target gene expression and DNA methylation to influence hepatic metabolic profiles across the life course. We utilized an established longitudinal mouse model of perinatal exposures to diethylhexyl phthalate and diison

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Szewczyńska, Małgorzata, Elżbieta Dobrzyńska, and Małgorzata Pośniak. "Determination of phthalates in particulate matter and gaseous phase emitted in indoor air of offices." Environmental Science and Pollution Research, September 22, 2020. http://dx.doi.org/10.1007/s11356-020-10195-3.

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AbstractPhthalate esters (PAEs) are endocrine disrupters and can disrupt the functioning of different hormones, causing adverse effects on human health. Due to the potential exposure to phthalates in office rooms, their concentrations in the air of these premises after their renovation and furnishing were determined. The aim of the study was to determine the content of these compounds in the gas phase and adsorbed on the particles. Thus, the combined sampler with filters and adsorption tube was used for air sampling. Samples were analyzed by GC-MS. The gas fraction was dominated by dimethyl ph

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21

Yi, Huan, Huamin Wu, Wenbin Zhu, et al. "Phthalate exposure and risk of ovarian dysfunction in endometriosis: human and animal data." Frontiers in Cell and Developmental Biology 11 (July 25, 2023). http://dx.doi.org/10.3389/fcell.2023.1154923.

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Objective: We aimed to explore the correlations between and possible mechanisms of common environmental endocrine disruptors, phthalates, and ovarian dysfunction in endometriosis.Methods: Subjects were included in the case group (n = 107) who were diagnosed with endometriosis by postoperative pathology in Fujian Maternal and Child Hospital from February 2018 to February 2021, and the women who were excluded from endometriosis by surgery were as the control group (n = 70). The demographic information of the subjects were evaluated by questionnaire, and the clinical characteristics were evaluate

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Hahn‐Townsend, Coral Kristine, Pratibha A. Varde, Puliyur S. MohanKumar, and Sheba M. MohanKumar. "METABOLIC DYSFUNCTION INDUCED BY PRENATAL EXPOSURE TO BISPHENOL‐A AND DIETHYL HEXYL PHTHALATE: EXACERBATION BY HIGH FAT DIET." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1293.6.

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Despite ongoing medical and scientific efforts, the incidence of obesity and metabolic disease continues to rise in the United States and shows an upward trend world‐wide. Many epidemiological studies suggest that exposure to endocrine disrupting chemicals (EDCs) could be associated with an increased risk of obesity and metabolic dysfunction. It has been shown that EDCs such as Bisphenol‐A (BPA) and diethylhexyl phthalate (DEHP) can cross the placenta and affect the developing fetus. Since the fetus is exceptionally sensitive to changes in hormones and altered endocrine signaling, it is highly

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Lin, Pi-I. D., Chia-Fang Wu, Hwang-Shang Kou, Tzu-Ying Huang, Jentaie Shiea, and Ming-Tsang Wu. "Removal of Diethylhexyl Phthalate from Hands by Handwashing: Evidence from Experimental N-of-1 and Crossover Designs." Scientific Reports 7, no. 1 (2017). http://dx.doi.org/10.1038/s41598-017-00581-2.

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Hideharu, Shintani. "Pretreatment, Analysis, Identification and Preparation of Toxic Compounds Eluted into Body Fluids from Medical and Dental Devices." October 1, 2014. https://doi.org/10.19070/2470-4490-140001.

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Selective analysis of toxic compounds in complicated matrix such as body fluids is extremely difficult. This is because unexpected interference admixtures with almost identical retention time in chromatography may co-elute with overlapping. 1t is essential to remove admixtures byappropriate pretreatment procedures. For that purpose there may be several sorts of pretreatment methods such as liquid-liquid extraction or solid phase extraction (SPE) using column, membrane dialysis filtration ultra-filtration super fluid critical extraction SFE or adsorption using charcoal or other appropriate adso

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Danilova, Elena, Farshid Ezligini, Connie Stöckel, Masafumi Asakawa, and Geir Hetland. "An evaluation of diethylhexyl phthalate free top & bottom in‐line blood collection set with a new soft housing filter." Transfusion Medicine, September 7, 2024. http://dx.doi.org/10.1111/tme.13091.

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AbstractBackground and ObjectivesDi (2‐ethylhexyl) phthalate (DEHP) plasticizer must be removed from polyvinylchloride (PVC) medical devices due to toxicity. DEHP/PVC blood bags were shown to provide stable quality under blood component production and to create good storage conditions for red blood cells concentrate (RBC). It is important that substitution of the DEHP maintains the RBC quality during storage, which should be achieved with Di (isononyl) cyclohexane‐1,2‐dicarboxylate (DINCH), although substitution of the plasticizer has been challenging.Materials and MethodsA DEHP‐free Top &

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