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Autor: Grafiati

Data publikacji: 30 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Stefanoff, P., M. Eidson, D. L. Morse, and A. Zielinski. "Evaluation of tickborne encephalitis case classification in Poland." Eurosurveillance 10, no. 1 (2005): 9–10. http://dx.doi.org/10.2807/esm.10.01.00514-en.

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Central European tickborne encephalitis (TBE) is a viral disease of the central nervous system. Despite a surveillance system for TBE existing in Poland since 1970, there are no standardised case definitions and different diagnostic tests are used in various regions. The purpose of this study was to summarise four years of surveillance data using standardised case definitions. From 1999 to 2002, 607 cases of TBE were reported to Poland’s national surveillance system: 386 (63.6%) were males, 331 (54.5%) lived in rural areas, and 186 (30.6%) were between 30 and 50 years old. Of 606 diagnosed cas

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Subedi, Deepak, Sumit Jyoti, Bhima Thapa, et al. "Knowledge, Attitude, and Practice of Antibiotic Use and Resistance among Poultry Farmers in Nepal." Antibiotics 12, no. 9 (2023): 1369. http://dx.doi.org/10.3390/antibiotics12091369.

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The abuse and misuse of antibiotics is one of the main drivers of antimicrobial resistance (AMR). Globally, AMR in food-producing animals is a significant public health concern. This study, therefore, assessed the knowledge, attitudes, and practices related to antibiotic usage (AMU) and AMR among poultry farmers in Nepal. We conducted a cross-sectional survey of 605 poultry farmers from six districts of Nepal from May to June 2022 to assess the status of knowledge, attitude, as well as practices toward prudent antibiotic usage (AMU) and AMR. The majority of the participants in our study were f

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Weber, Simone, Claudia Haferlach, Louisa Noel, et al. "ERG Overexpression Is Highly Associated With ERG Gene Amplifications In Patients With Myeloid Malignancies." Blood 122, no. 21 (2013): 3744. http://dx.doi.org/10.1182/blood.v122.21.3744.3744.

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Abstract Background The proto-oncogene ERG is located on chromosome 21q22 and overexpression of ERG was shown to have an adverse impact on outcome in cytogenetically normal AML (CN-AML). Acquired gain of chromosome 21 (+21) is a recurrent cytogenetic abnormality in AML, however, the pathogenetic impact remains elusive. Data indicate that +21 could be the underlying mechanism for altered expression of genes located in the respective regions, such as ERG, which might contribute to the pathogenesis in myeloid malignancies with +21. Aims 1) To investigate a possible relationship between ERG copy n

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Feng, Zhao Wei, Xu Jun Mi, Jiang Bo Wang, Zhi Shan Yuan, and Jin Zhou. "Effect of Annealing Temperature on the Transformation Temperature and Texture of Ni₄₇Ti₄₄Nb₉ Cold-Rolled Plate." Advanced Materials Research 557-559 (July 2012): 1281–87. http://dx.doi.org/10.4028/www.scientific.net/amr.557-559.1281.

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Transformation behaviors and texture of Ni47Ti44Nb9 cold-rolled plates were studied by differential scanning calorimetry and X-ray diffraction test. R phase transformation does not occur in Ni47Ti44Nb9cold-rolled plate annealed at 350°C-750°C followed by quenching into the water. Martensite transformation temperature first increases and then decreases with increment of annealing temperature, and the maximum achieves at 700°C. The heat of reverse martensite transformation increases, while hardness decreases as annealing temperature increases. The major texture of cold-rolled plate is {332} and

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Hálková, Tereza, Bohuš Bunganič, Eva Traboulsi, Marek Minárik, Miroslav Zavoral, and Lucie Benešová. "Prognostic Role of Specific KRAS Mutations Detected in Aspiration and Liquid Biopsies from Patients with Pancreatic Cancer." Genes 15, no. 10 (2024): 1302. http://dx.doi.org/10.3390/genes15101302.

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Background/Objectives: Although the overall survival prognosis of patients in advanced stages of pancreatic ductal adenocarcinoma (PDAC) is poor, typically ranging from days to months from diagnosis, there are rare cases of patients remaining in therapy for longer periods of time. Early estimations of survival prognosis would allow rational decisions on complex therapy interventions, including radical surgery and robust systemic therapy regimens. Understandably, there is great interest in finding prognostic markers that can be used for patient stratification. We determined the role of various

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Pavlyuchik, E. N., A. D. Kapsamun, N. N. Ivanova, T. N. Panteleeva, and N. A. Epifanova. "Agrophytocenoses based on promising varieties of meadow clover on drained lands of the Non-Chernozem zone." Agricultural Science Euro-North-East 21, no. 2 (2020): 152–59. http://dx.doi.org/10.30766/2072-9081.2020.21.2.152-159.

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The article presents data of studies carried out in the northwestern part of the Non-Chernozem zone (Tver region) in 2019. Studied were fodder mixtures based on meadow clover Kretunovsky, Green, Chance, Falensky 86 varieties mixed with variegated alfalfa Vega 87 variety and cereal components − timothy grass VIK 9 and meadow fescue Sakharovskaya varieties. The yield of dry weight of legumes and cereal grass stands of the first year of use during primary mowing in ferti-lized varieties was 4.4-6.9 t/ha at the height of grass stand of 66-77 cm and stalk density of 318-507 pcs/m2. The indicators i

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Ogata, Yutaka, Yoshito Akagi, Yoshihiro Kakeji, et al. "Phase II study alternating mFOLFOX 6 and FOLFIRI (FIREFOX) plus bevacizumab (bev) regimen in first-line treatment of advanced colorectal cancer in Japanese patients (KSCC 0801)." Journal of Clinical Oncology 30, no. 4_suppl (2012): 602. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.602.

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602 Background: The Kyushu Study group of Clinical Cancer conducted a phase II study that evaluated the FIREFOX regimen. (KSCC0701, Akagi et al, J Clin Oncol 28:15s, 2010). This study demonstrated the efficacy and mild neurotoxicity of this regimen. The present study evaluated the efficacy and safety of the FIREFOX plus bevacizumab (bev). Methods: Eligibility criteria included histologically confirmed advanced colorectal cancer, ECOG PS 0-2 and adequate bone marrow, renal and hepatic function. Patients (pts) received an alternating regimen of 4 cycles of mFOLFOX-6 plus bev (oxaliplatin 85 mg/m

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Furugaichi, A., M. Hoshina, J. Ito, and N. Kashiwazaki. "338 EFFECT OF OXYGEN CONCENTRATION ON NUCLEAR MATURATION, CUMULUS EXPANSION AND GLUTATHIONE LEVEL IN PORCINE OOCYTES DURING IN VITRO MATURATION." Reproduction, Fertility and Development 22, no. 1 (2010): 325. http://dx.doi.org/10.1071/rdv22n1ab338.

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Contrary to experimental animals, it is well known that pig oocytes show low developmental competence after IVM, fertilization and culture despite of the attempts to improve the IVM technology. One of the reasons causing such low developmental ability of porcine oocytes seems to be the culture condition, especially the gas phase for IVM because there is a large differences in oxygen tension between in vitro and in vivo conditions. Indeed, our preliminary study revealed that oocytes matured in vivo had larger perivitelline space than oocytes matured in vitro, which could be affected by in vitro

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Heikura, Ida A., Louise M. Burke, Dan Bergland, Arja L. T. Uusitalo, Antti A. Mero, and Trent Stellingwerff. "Impact of Energy Availability, Health, and Sex on Hemoglobin-Mass Responses Following Live-High–Train-High Altitude Training in Elite Female and Male Distance Athletes." International Journal of Sports Physiology and Performance 13, no. 8 (2018): 1090–96. http://dx.doi.org/10.1123/ijspp.2017-0547.

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Purpose: The authors investigated the effects of sex, energy availability (EA), and health status on the change in hemoglobin mass (ΔHbmass) in elite endurance athletes over ∼3–4 wk of live-high–train-high altitude training in Flagstaff, AZ (2135 m; n = 27 women; n = 21 men; 27% 2016 Olympians). Methods: Precamp and postcamp Hbmass (optimized carbon monoxide rebreathing method) and iron status were measured, EA was estimated via food and training logs, and a Low Energy Availability in Females Questionnaire (LEAFQ) and a general injury/illness questionnaire were completed. Hypoxic exposure (h)

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Rkiek, Bilal, Nadia Manar, Hicham El Bouri, Frédéric Deschamps, and Chakib Laraqui. "O-330 PREVALENCE OF RESPIRATORY SYMPTOMS, DISEASES AND VENTILATORY DISORDERSAMONG MARBLE WORKERS." Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.1236.

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Abstract Introduction The aim of this study was to assess the prevalence of respiratory symptoms, diseases and ventilatory defects. Methods This cross-sectional study involved 365 marble workers in Casablanca, and Agadir, with at least two years’ seniority. It included a questionnaire, spirometry and thoracic radiophotography. The questionnaire consisted of four sections: socio-demographic and occupational characteristics, smoking habits, medical history and clinical respiratory symptoms. Chronic bronchitis is defined as chronic cough and chronic sputum production occurring for at least three

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Kim, S. W., D. H. Kim, J. S. Seo, et al. "332 EMBRYONIC DEVELOPMENT AFTER SOMATIC CELL NUCLEAR TRANSFER OF PORCINE OOCYTES MEIOTICALLY INHIBITED WITH ROSCOVITINE." Reproduction, Fertility and Development 18, no. 2 (2006): 273. http://dx.doi.org/10.1071/rdv18n2ab332.

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Numerous factors affect on the developmental competence of cloned embryos, and one of the factors might be the disturbed synchronization of nuclear and cytoplasm maturation. Roscovitine, a purine known to specifically inhibit M-phase promoting factor (MPF) kinase activity by blocking the ATP in numerous cell systems, has been successfully used in maintaining porcine oocytes at GV stage without affecting their developmental potential. However, developmental ability of roscovitine treated porcine oocytes after nuclear transfer has not been evaluated. The purpose of this study was to examine the

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Zhao, Chengquan, Barbara A. Crothers, Z. Laura Tabatabai, et al. "False-Negative Interpretation of Adenocarcinoma In Situ in the College of American Pathologists Gynecologic PAP Education Program." Archives of Pathology & Laboratory Medicine 141, no. 5 (2017): 666–70. http://dx.doi.org/10.5858/arpa.2016-0234-cp.

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Context.— Adenocarcinoma in situ (AIS) is difficult to correctly interpret on Papanicolaou (Pap) cytology slides and false-negative interpretations of AIS can cause significant problems in daily practice. Objective.— To investigate the false-negative interpretation rate of AIS and the factors related to false-negative interpretation through responses in an educational environment. Design.— We retrospectively evaluated 11 337 responses in the PAP Education Program (PAP-Edu) from 173 AIS slides from 2011 to 2015. The false-negative interpretation rate, most common false-negative interpretations,

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Frane, Nicholas, Erik J. Stapleton, Brandon Petrone, Aaron Atlas, Larry Lutsky, and Randy M. Cohn. "Patient Satisfaction After Lower Extremity Total Joint Arthroplasty: An Analysis of Medical Comorbidities and Patient Demographics." Journal of Patient Experience 8 (January 1, 2021): 237437352110180. http://dx.doi.org/10.1177/23743735211018089.

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The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey has received increased attention to determine which demographics may influence patient satisfaction after Total Hip and Knee Arthroplasty. The purpose of this study was to evaluate the various effects that patient-specific factors, medical comorbidities, and demographics had on patient satisfaction. Two thousand and ninety-two patients underwent lower extremity total joint arthroplasty at our institution between 2014 and 2018. Nine hundred twenty-three of these patients responded to their HCAHPS survey (44%).

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Kazemi, Rojin, Ardashir Sheikhahmadi, and Ghorbanali Sadeghi. "The effect of purslane hydroextract and zinc on performance, antioxidant capacity and immunity of broiler chickens during summer conditions." Archives Animal Breeding 61, no. 3 (2018): 365–71. http://dx.doi.org/10.5194/aab-61-365-2018.

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Abstract. Due to negative effects of high ambient temperature, the present study was conducted to investigate the effects of Portulaca oleracea hydroextract (PHE) and zinc (Zn) on the growth performance and immunity of broiler chickens reared under high summer ambient temperature conditions. A total of 420 day-old male broiler chickens (Ross 308) were randomly allocated to seven dietary treatments each replicated four times with 15 birds per replicate. The basal diet as the control diet was supplemented with 100 mg kg−1 butylated hydroxytoluene (BHT), or 300 and 600 mg kg−1 of PHE, 100 mg kg−1

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Van Den Eynde, Marc, Bernhard Mlecnik, Jean-Pascal H. Machiels, et al. "Preoperative treatment to modify the immune microenvironnement of liver colorectal metastases." Journal of Clinical Oncology 33, no. 3_suppl (2015): 602. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.602.

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602 Background: We previously reported that an adaptive Th1 immune response (CD3/CD8/CD45RO T-cells) observed in resected primary colorectal tumor and liver colorectal metastases (LCM) is an important prognostic factor. B and FoxP3 regulatory lymphocytes participate to the modulation of this response. We aimed to investigate whether the preoperative treatments influenced the quality and the density of the immune infiltrates previously reported in the LCM. Methods: We used a cohort of metastatic colorectal patients (n=107) engaged for curative liver surgery with available FFPE blocks for all re

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Maham Shah, Nida Talpur, Farwa Shah, Atia Gul Bhurt, Bibi Ume- Habiba Shah, and Amna Shah Syed. "Relationship of family related factors with dental caries prevalence in 5 years old children of different schools of Hyderabad." JMMC 12, no. 1 (2022): 51–54. http://dx.doi.org/10.62118/jmmc.v12i1.201.

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Introduction: The habits children have included in life; continues to make the choices they make as adults. According to social learning theory these habits are derived through supervision, learning and modelling. For a child, most significant are primarily father and mother and their immediate family members. All these factors have the collective ability to influence the child's oral health outcomes. Objective: To examine the dental caries rate in 5 year’s old school children and influence of their family related habits and socio demographic factors on child’s dental caries experience a

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Jahan, Nusrat, Yiwen Zhao, Katarina Blagovic, et al. "Abstract 6660: The novel codon-modified Zika virus CDX-602 shows anti-tumor efficacy and remodels the tumor microenvironment in preclinical models." Cancer Research 84, no. 6_Supplement (2024): 6660. http://dx.doi.org/10.1158/1538-7445.am2024-6660.

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Abstract Multiple oncolytic viruses have been shown to induce multifaceted changes in the tumor microenvironment, that ultimately support induction of anti-tumor immune responses. We have previously demonstrated that CodaLytic, a codon-modified influenza virus, can kickstart the cancer immunity cycle at various steps in several mouse models with differing baseline immune contextures. Here, we are describing the activity of a new codon-modified virotherapeutic derived from the same synthetic viral engineering platform [Coleman et al., Science 2008]. Zika virus strain MR766 was synthetically cod

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Pompa-Monroy, Daniella Alejandra, Ana Leticia Iglesias, Syed Gulam Dastager, et al. "Comparative Study of Polycaprolactone Electrospun Fibers and Casting Films Enriched with Carbon and Nitrogen Sources and Their Potential Use in Water Bioremediation." Membranes 12, no. 3 (2022): 327. http://dx.doi.org/10.3390/membranes12030327.

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Augmenting bacterial growth is of great interest to the biotechnological industry. Hence, the effect of poly (caprolactone) fibrous scaffolds to promote the growth of different bacterial strains of biological and industrial interest was evaluated. Furthermore, different types of carbon (glucose, fructose, lactose and galactose) and nitrogen sources (yeast extract, glycine, peptone and urea) were added to the scaffold to determinate their influence in bacterial growth. Bacterial growth was observed by scanning electron microscopy; thermal characteristics were also evaluated; bacterial cell grow

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Barrett, Steve, Adrian Midgley, and Ric Lovell. "PlayerLoad™: Reliability, Convergent Validity, and Influence of Unit Position during Treadmill Running." International Journal of Sports Physiology and Performance 9, no. 6 (2014): 945–52. http://dx.doi.org/10.1123/ijspp.2013-0418.

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Purpose:The study aimed to establish the test–retest reliability and convergent validity of PlayerLoad™ (triaxial-accelerometer data) during a standardized bout of treadmill running.Methods:Forty-four team-sport players performed 2 standardized incremental treadmill running tests (7–16 km/h) 7 d apart. Players’ oxygen uptake (VO2; n = 20), heart rate (n = 44), and triaxialaccelerometer data (PlayerLoad; n = 44) measured at both the scapulae and at the center of mass (COM), were recorded. Accelerometer data from the individual component planes of PlayerLoad (anteroposterior [PLAP], mediolateral

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Patel, Priti, Mayra Telesca, and De-Hui Ku. "The Comparison of Fibrin Monomer (FM) Performance to Other Activation Markers (TAT, PF1.2 and DD)." Blood 118, no. 21 (2011): 5259. http://dx.doi.org/10.1182/blood.v118.21.5259.5259.

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Abstract Abstract 5259 In this study, we attempted to determine the performance of the soluble fibrin monomer complex (SFMC) test in comparison to known activation markers, such as prothrombin fragment 1.2 (PF1.2), thrombin antithrombin complex (TAT) and d-dimer (DD). We have used the STA(R)-Liatest FM and STA(R)-Liatest D-Di kits to measure the SFMC and d-dimer levels. A total of 25 patients were included in this study. The data and demographic information are shown in the table below. ID GENDER AGE FM TAT PF1.2 D-dimer 1 M 66 0.42 2.3 1988 0.05 2 F 31 27.93 >60.0 >12000 2.39 3 F 24 3.4

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Trypolsky, O. A., O. V. Topoliuk, O. O. Trypolska, and O. B. Gintov. "Results of the reinterpretation of materials of IV geotraverse of NHS (PK 295- 400) in the central part of the Holovanivsk suture zone." Reports of the National Academy of Sciences of Ukraine, no. 1 (February 2021): 58–64. http://dx.doi.org/10.15407/dopovidi2021.01.058.

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This work provides the reinterpretation results of the research outcomes with the DSS method on geotraverse IV on section PK 295-400 in order to clarify a seismic section in the Holovanivsk area of high gravity. A number of points of diffraction and seismic sites have been identified in Earth’s crust (at a depth of 2-60 km), which gives an opportunity to considerably specify the data on the deep structure of the studied area. The position in a section of the Talnivska fault zone is clarified due to the identification of additional points of diffraction and a large number of short reflective el

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Metcalf, M. G., V. Braiden, and J. H. Livesey. "Retention of normal ovarian function after hysterectomy." Journal of Endocrinology 135, no. 3 (1992): 597–602. http://dx.doi.org/10.1677/joe.0.1350597.

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ABSTRACT What are the long-term effects of hysterectomy on the ovaries of normal women? Ninety-three women aged 29–44 years (median, 38 years) who had undergone hysterectomy for benign reasons 0·3–9·1 years prior to investigation, contributed urine samples twice weekly for a period of 53–149 days (median 102 days) for pregnanediol analysis. The interval between successive pregnanediol peaks and their increment over baseline were measured. The median peak interval was 27·3 days, and 93·3% of all intervals were of 21- to 35-days duration. Of the 337 peaks observed, 96·7% met the criteria previou

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Wang, Jianzhu, Kunyuan Gao, Xiangyuan Xiong, et al. "The Influence of Precipitated Particles on the Grain Size in Cold-Rolled Al–Mn Alloy Foils upon Annealing at 100–550 °C." Materials 17, no. 7 (2024): 1671. http://dx.doi.org/10.3390/ma17071671.

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The Al–Mn alloy heat exchanger fin production process includes a brazing treatment at s high temperature of 600 °C, in which coarse grains are preferred for their high resistance to deformation at elevated temperatures by decreasing the grain boundary sliding. In this study, Al-1.57Mn-1.57Zn-0.58Si-0.17Fe alloy foils cold rolled by 81.7% (1.1 mm in thickness) and 96.5% (0.21 mm in thickness) were annealed at 100–550 °C for 1 h to investigate their recrystallization behavior, grain sizes, and precipitates by increasing the annealing temperature, using micro-hardness measurement, electron back-s

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Shaikh, Yasar Arafath. "Study of pleural effusion in chronic kidney disease patient undergoing hemodialysis in Andhra Pradesh population." International Journal of Advances in Medicine 6, no. 4 (2019): 1262. http://dx.doi.org/10.18203/2349-3933.ijam20193282.

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Background: About 85 patients aged between 30 to 65 years suffering with chronic kidney disease with pleural effusion undergoing hemodialysis were studied.Methods: X-ray, USG and Biochemical study was performed to confirm the Diagnosis.Results: The clinical manifestation was 17 (20%) had hypertension (HTN), 16 (18.8%) had DM (Diabetes mellitus), 12 (14.1%) had cardiac disease 9 (10.5%), had cardiovascular disease, 5 (5.8%) had malignancy. 10 (11.7%), had COPD, 13 (15.2%) had hepatitis 3 (3.5%) had thyroid disease, Hb%, profile was 40 (47%), had 9 to 9.5%, 45 (52.9%) had 10 to 10.5, protein (to

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Diamantopoulos, Panagiotis Theodorou, Konstantinos Zervakis, Athanasios G. Galanopoulos, et al. "Decrease in Transfusion Needs in Patients with Higher-Risk Myelodysplastic Syndrome and Acute Myeloid Leukemia Treated with 5-Azacytidine. a Retrospective Study." Blood 124, no. 21 (2014): 5608. http://dx.doi.org/10.1182/blood.v124.21.5608.5608.

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Abstract Introduction The hypomethylating agent 5-azacytidine (AZA) has been the standard of care for higher risk Myelodysplastic Syndromes (MDS) for the last few years. Its efficacy has been proven in large clinical trials, and its safety has been shown to be superior to that of conventional treatments. We have conducted a retrospective study about the efficacy and safety of 5-azacytidine, as reported and analyzed in our center. Patients and Methods Forty four consecutive patients with MDS or Acute Myeloid Leukemia (AML) with 20-30% bone marrow blasts that were treated with AZA during the las

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Feagan, Brian, David Rubin, Stephen Hanauer, et al. "ENDOSCOPIC SCORE INTER-READER CONCORDANCE ANALYSIS FROM A PHASE 2B STUDY IN PATIENTS WITH MILD-TO-MODERATE UC." Inflammatory Bowel Diseases 29, Supplement_1 (2023): S18—S19. http://dx.doi.org/10.1093/ibd/izac247.036.

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Abstract BACKGROUND Endoscopic assessment of disease severity is a key component of ulcerative colitis (UC) clinical studies. However, interobserver variability may contribute to bias in selecting study candidates and evaluating response rates. Scoring by blinded central readers has become the recommended standard method of assessment to minimize bias and interobserver variance. We present concordance rates between central and local readings from a Phase 2b study of investigational microbiome therapeutic SER-287 in patients with mild-to-moderate UC. METHODS This double-blind, placebo-controlle

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Singh, Pranisha, Anu Mishal, and Jay Sundar Sunarait. "Ophthalmic Causes of Headache among Patients Attending Tertiary Care Center in Kathmandu, Nepal." Nepal Medical College Journal 23, no. 3 (2021): 235–40. http://dx.doi.org/10.3126/nmcj.v23i3.40383.

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The purpose of this study was to evaluate the ophthalmic causes of headache among patients attending tertiary care hospital. This was a descriptive, cross sectional hospital-based study. One hundred and thirty-two patients with ocular cause of headache excluding primary headache and pediatrics patients during one year were included. Detail ocular examination was done including visual acuity, refraction, binocular vision assessment like convergence insufficiency and fusional insufficiency, anterior and posterior segment examination. Among headache patients, female was 106 (80.3%) and male was 2

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Gao, Jun-Feng, Lu Zhou, Ai-Hui Zhang, et al. "Prevalence and Molecular Characterization of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi in Cattle in Heilongjiang Province, Northeast China." Animals 14, no. 11 (2024): 1635. http://dx.doi.org/10.3390/ani14111635.

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Crytosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi are important diarrheal pathogens with a global distribution that threatens the health of humans and animals. Despite cattle being potential transmission hosts of these protozoans, the associated risks to public health have been neglected. In the present study, a total of 1155 cattle fecal samples were collected from 13 administrative regions of Heilongjiang Province. The prevalence of Cryptosporidium spp., G. duodenalis, and E. bieneusi were 5.5% (64/1155; 95% CI: 4.2–6.9), 3.8% (44/1155; 95% CI: 2.7–4.9), and 6.5% (75/1155;

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Somani, Bhaskar K., Amelia Pietropaolo, Primrose Coulter, and Julian Smith. "Delivery of urological services (telemedicine and urgent surgery) during COVID-19 lockdown: experience and lessons learnt from a university hospital in United Kingdom." Scottish Medical Journal 65, no. 4 (2020): 109–11. http://dx.doi.org/10.1177/0036933020951932.

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Background and aims Our departmental planning for COVID-19 was actioned a week before the lockdown (13th March 2020). We look at a 7- week lockdown activity for all scheduled outpatient clinics and urgent procedures. Methods and results A total of 2361 outpatient clinic slots (52.6% oncology slots and 47.4% benign urology slots) were scheduled during this period. The oncology slots included 330 (26.5%) flexible cystoscopy, 555 (44.7%) prostate cancer and 357(28.8%) non-prostate cancer slots. The benign urology slots included 323 (28.8%) andrology, 193 (17.2%) stones and 603 (54%) lower urinary

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Hehlmann, Rüdiger, Michael Lauseker, Susanne Jung-Munkwitz та ін. "Tolerability-Adapted Imatinib 800 mg/d Versus 400 mg/d Versus 400 mg/d Plus Interferon-α in Newly Diagnosed Chronic Myeloid Leukemia". Journal of Clinical Oncology 29, № 12 (2011): 1634–42. http://dx.doi.org/10.1200/jco.2010.32.0598.

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Purpose Treatment of chronic-phase (CP) chronic myeloid leukemia (CML) with imatinib 400 mg/d can be unsatisfactory. Optimization of treatment is warranted. Patients and Methods In all, 1,014 newly diagnosed CP-CML patients were randomly assigned to imatinib 800 mg/d (n = 338), imatinib 400 mg/d (n = 325), or imatinib 400 mg/d plus interferon alfa (IFN-α; n = 351). Dose adaptation to avoid higher-grade toxicity was recommended. First primary end point was major molecular remission (MMR) at 12 months. Results A higher rate of MMR at 12 months occurred with tolerability-adapted imatinib 800 mg/d

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Beniova, S. N., P. F. Kiku, B. I. Gel’tser, et al. "Prevention of osteoporosis with the use of the product of specialized medical nutrition." Kazan medical journal 97, no. 5 (2016): 727–31. http://dx.doi.org/10.17750/kmj2016-727.

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Aim. To study the efficacy of shellfish dry extract with «Calcium-reparative» filler as a product of specialized medical nutrition to optimize bone metabolism.Methods. Total of 44 female patients aged from 49 to 71 years, mean age of 54.5±3.8 years, with a combination of several osteoporosis risk factors were involved. 72.7% of all patients complained of pain of varying severity in major joints, in the thoracic and lumbar spine. The patients were randomly divided into two groups - study group (29 patients) and control group (15 patients). Within 30 days, the participants of the study group rec

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Takata, Ryo, Hiroki Nishikawa, Hirayuki Enomoto, et al. "Association between Albumin-Bilirubin Grade and Non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases." Journal of Clinical Medicine 8, no. 9 (2019): 1485. http://dx.doi.org/10.3390/jcm8091485.

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We sought to elucidate the relationship between albumin-bilirubin (ALBI) grade and non-protein respiratory quotient (npRQ) calculated by indirect calorimetry in chronic liver disease (CLD) patients (n = 601, median age = 63 years). Factors linked to npRQ < 0.85, which is reported to be an optimal cutoff point for the prognosis in liver cirrhosis (LC) patients, were also investigated using univariate and multivariate analyses. The median npRQ for all cases was 0.86. In total, 253 patients (42.1%) had npRQ < 0.85. The proportions of patients with npRQ < 0.85 in LC and non-LC patients we

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Thom, Bridgette, Amy L. Tin, Fumiko Chino, Andrew Vickers, and Emeline Mariam Aviki. "Validating a simplified financial toxicity screening tool for patients with cancer." JCO Oncology Practice 20, no. 10_suppl (2024): 318. http://dx.doi.org/10.1200/op.2024.20.10_suppl.318.

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318 Background: Medical-related financial hardship (called financial toxicity) can negatively impact patient clinical outcomes and overall well-being. Routine financial toxicity screening is recommended to facilitate referrals to resources for patients experiencing, or at risk for, financial toxicity. The validated Comprehensive Score for Financial Toxicity (COST) tool is widely used in research to measure financial toxicity; however, its 11-question length and lack of standardized screening threshold make it challenging to implement in clinical practice. This analysis sought to develop and va

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Alsowaida, Yazed Saleh, David W. Kubiak, Brandon Dionne, Mary P. Kovacevic, and Jeffrey C. Pearson. "Vancomycin Area under the Concentration-Time Curve Estimation Using Bayesian Modeling versus First-Order Pharmacokinetic Equations: A Quasi-Experimental Study." Antibiotics 11, no. 9 (2022): 1239. http://dx.doi.org/10.3390/antibiotics11091239.

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Aim: To evaluate the efficiency of Bayesian modeling software and first-order pharmacokinetic (PK) equations to calculate vancomycin area under the concentration-time curve (AUC) estimations. Methods: Unblinded, crossover, quasi-experimental study at a tertiary care hospital for patients receiving intravenous vancomycin. Vancomycin AUC monitoring was compared using Bayesian modeling software or first-order PK equations. The primary endpoint was the time taken to estimate the AUC and determine regimen adjustments. Secondary endpoints included the percentage of vancomycin concentrations usable f

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Asif, M. U., R. Muhammad, W. Akber, and M. Tofique. "Relative Efficacy of Some Insecticides Against the Sucking Insect Pest Complex of Cotton." Nucleus 53, no. 2 (2017): 140–46. https://doi.org/10.71330/thenucleus.2016.226.

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The comparative efficacy of some conventional and neonicotinoid insecticides for the management of sucking insect pests of cotton (whitefly, jassid and thrips) was determined. Six insecticides viz., Confidor 200 SL (imidacloprid)@ 100 ml acre-1, Karate 1.5 EC (lambda cyhalothrin)@ 330 ml acre-1, Nockout 25 SP (nitenpyram)@ 100 gm acre-1, Polytrin-C 44 EC (profenofos+cypermethrin)@ 600 ml acre-1, Talstar 10 EC (bifenthrin)@ 250 ml acre-1 and Advantage 20 EC (carbosulfan)@ 1000 ml acre-1 were sprayed twice in order to ascertain the reduction of the pests population on Sadori variety of cotton so

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Longo, Nicola, Francesco Di Bello, Luigi Napolitano, et al. "Outcomes of Salvage Treatment After Primary Treatment for Renal Cell Cancer: A Systematic Review." Diagnostics 15, no. 7 (2025): 838. https://doi.org/10.3390/diagnostics15070838.

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Background/Objective: The grade of recommendation for renal cell carcinoma (RCC) salvage treatment options is weak. The aim of the current study is to summarize available evidence about the surgical, oncological, and functional outcomes of salvage renal options after previous treatments for RCC. Methods: A systematic search (PROSPERO: CRD42024618629) was performed according to the PRISMA statement. A pooled analysis was performed to quantify the effect size (ES) for an overall postoperative Clavien–Dindo (CD) grade ≥ III and postoperative and intraoperative complications for either partial or

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Trovato, Giovanni, Maria Bensi, Viria Beccia, et al. "Second-line chemotherapy in elderly patients with advanced pancreatic cancer: A mono-institutional retrospective experience." Journal of Clinical Oncology 42, no. 3_suppl (2024): 606. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.606.

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606 Background: Only few randomized clinical trials have been conducted for second line therapy in advanced pancreatic cancer (APC). In these studies, elderly patients are poorly represented, even if the median age at diagnosis of APC is increasing; therefore, limited efficacy and safety data are available. Here, we present a retrospective monocentric analysis of second line chemotherapy in elderly patients treated at our Hospital. Methods: This study included patients with APC and aged>70 years old receiving a second-line chemotherapy for APC at our institution from March 2015 to August 20

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Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 850.1–850. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven

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Sanchez-Osorio, J., C. Cuello, J. Gomis, et al. "90 OPEN PULLED STRAW VITRIFICATION OF IN VITRO PORCINE BLASTOCYTS IN A CHEMICALLY DEFINED MEDIUM." Reproduction, Fertility and Development 23, no. 1 (2011): 150. http://dx.doi.org/10.1071/rdv23n1ab90.

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The aim of this study was to design a chemically defined medium for the vitrification of in vitro produced porcine blastocysts avoiding the use of serum or serum components. Cumulus–oocyte complexes were matured in vitro in NCSU-23 for 44 h and were inseminated with frozen–thawed spermatozoa. Presumptive zygotes were cultured for 16 h to assess in vitro fertilization (IVF) parameters (N = 200) or for 6 days (N = 600) in order to obtain blastocysts. For chemically delipidation, 10 μM forskolin was added to the culture medium on Day 5 of in vitro culture. On Day 2, embryos were evaluated for cle

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Zhou, J., J. Liu, Y. Wang, and W. Zheng. "FRI0225 THE CLINICAL FEATURES AND OUTCOME OF VENA CAVA INVOLVEMENT IN BEHCET’S DISEASE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 695.1–696. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4507.

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Background:Behcet’s disease (BD) is a systemic disease that can affect vessels of any size and type. However, only limited cases of BD patients with vena cava involvement have been reported.Objectives:To investigate the clinical features and outcome of vena cava involvement in BD patients.Methods:We retrospectively reviewed the clinical data of BD patients with vena cava involvement in our institute from August 2001 to October 2019. The treatment and outcome of these patients were also analyzed.Results:Fifty BD patients with vena cava involvement were included. The median interval between BD o

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Rea, D., S. J. Bowden, L. Gross, et al. "NEAT-A: Accelerated sequential epirubicin followed by CMF using pegfilgrastim is a feasible regimen for delivering dose dense chemotherapy in early breast cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 11001. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.11001.

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11001 Background: E-CMF [epirubicin (E) x 4 cycles every (q) 21 days (d), followed by classical CMF x 4 cycles q 28d] is established as highly effective adjuvant chemotherapy for early breast cancer (BC), reducing mortality by 30% compared with CMF alone [Poole NEJM 2006]. However, dose dense anthracycline-taxane schedules, accelerated with GCSF support, have been shown to be superior to conventional regimens [Citron JCO 2003, Burnell SABCS 2006]. Exploration of accelerated E-CMF is therefore of considerable interest. Methods: A non-randomised, multicenter trial was designed to explore the fea

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Pothugunta, Krishna, Santhi Voora, Holly Joy Kramer, Anil K. Bidani, and Kavitha Vellanki. "Outcomes of Albumin Use in the Treatment of Acute Hepatorenal Disorders: A Single Center Experience." Journal of Renal and Hepatic Disorders 1, no. 1 (2017): 5–10. http://dx.doi.org/10.15586/jrenhep.2017.2.

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Intravenous albumin is recommended for hepatorenal disorders (HRD), but individuals who do not recover renal function may be at a high risk for pulmonary edema. We reviewed outcomes by the amount of albumin infused in 93 patients not receiving dialysis at admission but being treated with intravenous albumin for acute HRD at our institution. Absence of renal recovery was defined as no decrease in serum creatinine and requirement of dialysis during hospitalization, and partial renal recovery was defined as a decrease in serum creatinine but not to prehospitalization levels. Associations of clini

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Watanabe, Takayo, Hiroshi Keino, Kyoko Nakayama, Wakako Taki, Nariaki Echizen, and Annabelle A. Okada. "Clinical features of patients with diabetic anterior uveitis." British Journal of Ophthalmology 103, no. 1 (2018): 78–82. http://dx.doi.org/10.1136/bjophthalmol-2017-311453.

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AimTo describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus.MethodsRetrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center.ResultsOcular findings at presentation included posterior synechiae (15 eyes, 60%), anterior chamber fibrin (13 eyes, 52%), keratic precipitates (10 eyes, 40%), Descemet membrane folds (7 eyes, 28%) and hypopyon (3 eyes, 12%). Seven cases were bilateral. Intraocular pressure >21 mm

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Devlin, John W., Jeffrey J. Fong, Elizabeth P. Howard, et al. "Assessment of Delirium in the Intensive Care Unit: Nursing Practices And Perceptions." American Journal of Critical Care 17, no. 6 (2008): 555–65. http://dx.doi.org/10.4037/ajcc2008.17.6.555.

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Background Despite practice guidelines promoting delirium assessment in intensive care, few data exist regarding current delirium assessment practices among nurses and how these practices compare with those for sedation assessment. Objectives To identify current practices and perceptions of intensive care nurses regarding delirium assessment and to compare practices for assessing delirium with practices for assessing sedation. Methods A paper/Web-based survey was administered to 601 staff nurses working in 16 intensive care units at 5 acute care hospitals with sedation guidelines specifying de

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Bustinduy, Amaya L., Irina Chis Ster, Rebecca Shaw, et al. "Predictors of fever-related admissions to a paediatric assessment unit, ward and reattendances in a South London emergency department: the CABIN 2 study." Archives of Disease in Childhood 102, no. 1 (2016): 22–28. http://dx.doi.org/10.1136/archdischild-2016-310494.

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ObjectiveTo explore the risk factors for ward and paediatric assessment unit (PAU) admissions from the emergency department (ED).DesignProspective observational study.Setting and patientsFebrile children attending a large tertiary care ED during the winter of 2014–2015.Main outcome measuresWard and PAU admissions, National Institute for Health and Care Excellence (NICE) guidelines classification, reattendance to the ED within 28 days and antibiotic use.ResultsA total of 1097 children attending the children's ED with fever were analysed. Risk factors for PAU admission were tachycardia (RR=1.1,

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Lestary, Afnita, Lily Irsa, Tiangsa Sembiring, Rita Evalina, and Meiviliani Sinaga. "Association of body mass index with atopy and allergic diseases." Paediatrica Indonesiana 56, no. 4 (2016): 221. http://dx.doi.org/10.14238/pi56.4.2016.221-5.

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Background Prevalence of atopy, allergic diseases, and obesity are increasing. Atopy is an individu and/or familial tendency to sensitization in response to ordinary exposure to allergens. Obesity is defined as body mass index (BMI) greater or equal to 95 percentile. Research on association of BMI with atopy and allergic diseases in children were limited, with inconclusive results. Objective To assess association of BMI with atopy and allergic diseases in chidren.Methods A cross-sectional was conducted in school children aged 6-12 years in Lhokseumawe City, Aceh, June 2012. Children were asses

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Chanpattana, W. "A Survey of the Practice of Electroconvulsive Therapy in Asia." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71003-x.

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Background:To describe a comprehensive survey of the practice of electroconvulsive therapy (ECT) in Asia.Method:Between 2001 and 2003, a 29-item questionnaire was sent to 977 psychiatric facilities in 45 Asian countries.Results:Completed questionnaires were returned by 334 (34.2%) institutions in 29 (64.4%) countries. ECT was available in 257 institutions in 23 countries. During the year before the survey, 39,875 patients (62% male) received a mean of 7.1 ECT treatments. Most patients (73.1%) were 18-44 years old; few were < 18 (6.0%) or >64 (4.4%) years old. Indications for ECT were sch

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Hebart, Holger Frithjof, Jiri Tomasek, Tibor Csõszi, et al. "Clinical practice use of panitumumab combined with chemotherapy in patients with wild-type RAS metastatic colorectal cancer." Journal of Clinical Oncology 36, no. 4_suppl (2018): 852. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.852.

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852 Background: This study aimed to understand panitumumab (pmab) use in clinical practice for patients with wild-type RAS metastatic colorectal cancer (mCRC), in first-line (1L) with FOLFOX or second-line (2L) with FOLFIRI following fluoropyrimidine-based chemotherapy (excl. irinotecan). Methods: This is a combined analysis of two observational, non-interventional prospective cohort studies conducted in Germany/France (2012-2016) and Bulgaria/Czech Republic/Hungary (2013-2016). Results: Results are presented in the order of 1L FOLFOX (n = 332) followed by 2L FOLFIRI (n = 94). Patients receive

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Escobar-Lazcano, Mari Jose, Eduardo Morteo, Christian Alejandro Delfín-Alfonso, Isabel del Carmen Hernández-Candelario, and Luis Gerardo Abarca-Arenas. "Trends and gaps in marine mammal research from Mexico during 1998 – 2021." Latin American Journal of Aquatic Mammals 18, no. 1 (2023): 39–49. http://dx.doi.org/10.5597/lajam00299.

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Marine mammals are very diverse because of the oceanographic conditions of Mexican waters (where 36% of the current species worldwide are found); however, scientific research on many of these taxa is still at the basic stages. The goal of this study was to assess the scientific information available for these species and to determine research priorities through a GAP (from the acronym "Good", "Average", and "Poor”) analysis. Information from the abstracts of the meetings held by the Mexican Society of Marine Mammalogy (SOMEMMA) and online databases (SCOPUS and Web of Science) between 1998 and

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Zhang, Lu-Lu, Jia Ren, Yun Wang, and En-Wei Liang. "Very-high-energy Gamma-Ray Afterglows of GRB 201015A and GRB 201216C." Astrophysical Journal 952, no. 2 (2023): 127. http://dx.doi.org/10.3847/1538-4357/acd190.

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Abstract Gamma-ray bursts (GRBs) 201015A and 201216C are valuable cases where very-high-energy (VHE) gamma-ray afterglows have been detected. By analyzing their prompt emission data, we find that GRB 201216C is an extremely energetic, long GRB with a hard gamma-ray spectrum, while GRB 201015A is a relative subenergetic, soft-spectrum GRB. Attributing their radio–optical–X-ray afterglows to the synchrotron radiation of the relativistic electrons accelerated in their jets, we fit their afterglow lightcurves with the standard external shock model and infer their VHE afterglows from the synchrotro

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