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Artykuły w czasopismach na temat „4-dihydroxyphenylalanine”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 10 lutego 2022

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1

Wolfovitz, Efrat, Ehud Grossman, Carol J. Folio, Harry R. Keiser, Irwin J. Kopin, and David S. Goldstein. "Derivation of Urinary Dopamine from Plasma Dihydroxyphenylalanine in Humans." Clinical Science 84, no. 5 (May 1, 1993): 549–57. http://dx.doi.org/10.1042/cs0840549.

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1. Dihydroxyphenylalanine is the precursor of all endogenous catecholamines. In laboratory animals, renal uptake and decarboxylation of circulating dihydroxyphenylalanine accounts for most of dopamine in urine. Dopamine is natriuretic, and in rats, dietary salt loading increases renal dihydroxyphenylalanine uptake by increasing the rate of entry (spillover) of dihydroxyphenylalanine into arterial plasma. In experimental animals and in humans, dietary salt loading increases urinary excretion of dihydroxyphenylalanine and dopamine. The present study examined in humans the extent to which circula

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2

Matsushita, Naoko, Yoshimi Misu, and Yoshio Goshima. "In vivo antagonism of the behavioral responses to L-3-,4-dihydroxyphenylalanine by L-3-,4-dihydroxyphenylalanine cyclohexyl ester in conscious rats." European Journal of Pharmacology 605, no. 1-3 (March 2009): 109–13. http://dx.doi.org/10.1016/j.ejphar.2008.12.032.

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3

Adamiec, J., K. Cejpek, J. Rössner, and J. Velíšek. "Novel Strecker degradation products of tyrosine and dihydroxyphenylalanine." Czech Journal of Food Sciences 19, No. 1 (February 7, 2013): 13–18. http://dx.doi.org/10.17221/6568-cjfs.

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Tyrosine was oxidised with either potassium peroxodisulphate or glyoxal. Volatile reaction products were isolated and analysed by GC/FID and GC/MS, derivatised with diazomethane and analysed by the same methods. Eight reaction products were identified. The major products were the expected Strecker aldehyde (4-hydroxyphenylacetaldehyde) and its lower homologue 4-hydroxybenzaldehyde. They were followed by 1-(4-hydroxyphenyl)-3-propionaldehyde, phenylacetaldehyde, benzaldehyde, phenol, 4-hydroxybenzoic, and benzoic acid. Analogously, the oxidation of 3,4-dihydroxyphenylalanine yielded the corresp

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4

GOLDSTEIN, DAVID S. "Plasma 3, 4-Dihydroxyphenylalanine (Dopa) and Catecholamines in Neuroblastoma or Pheochromocytoma." Annals of Internal Medicine 105, no. 6 (December 1, 1986): 887. http://dx.doi.org/10.7326/0003-4819-105-6-887.

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5

Chen, Lisha, Fengxia Chang, Lingchen Meng, Meixian Li, and Zhiwei Zhu. "A novel electrochemical chiral sensor for 3,4-dihydroxyphenylalanine based on the combination of single-walled carbon nanotubes, sulfuric acid and square wave voltammetry." Analyst 139, no. 9 (2014): 2243–48. http://dx.doi.org/10.1039/c4an00098f.

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6

Xiong, Xiong, Ding Hai Li, and Yue Feng Wang. "Differences in Thermal Stability and Surface Morphology of Dopa and Dopamine Graft Compound." Advanced Materials Research 641-642 (January 2013): 951–54. http://dx.doi.org/10.4028/www.scientific.net/amr.641-642.951.

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L-3, 4-Dihydroxyphenylalanine(DOPA) has a unique catechol moiety found in adhesive proteins in marine organisms, such as mussels and polychaete, which results in strong adhesion in aquatic conditions. Conventional efforts incorporating DOPA into polymer is grafting methacrylate anhydride. For this reason, we synthesized the new catechol intermediate N-methacryloyl 3,4-dihydroxyl-phenylamine and analyzed the surface morphology and thermal stability of it.

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7

Tamura, Sadaaki, Teruhiko Nitoda, and Isao Kubo. "Effects of Salicylic Acid on Mushroom Tyrosinase and B16 Melanoma Cells." Zeitschrift für Naturforschung C 62, no. 3-4 (April 1, 2007): 227–33. http://dx.doi.org/10.1515/znc-2007-3-412.

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Abstract Salicylic acid slightly inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.

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8

Forster, Christine, George Naik, and Paul W. Armstrong. "Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog." Canadian Journal of Physiology and Pharmacology 72, no. 1 (January 1, 1994): 45–49. http://dx.doi.org/10.1139/y94-008.

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We have modified an assay utilizing ion-pair high-performance liquid chromatography with electrochemical detection to measure dihydroxyphenylalanine and dyhydroxyphenylglycol simultaneously with noradrenaline. We measured these agents at control, 1 and 3 weeks following the onset of rapid ventricular pacing, as well as 4 weeks after the cessation of a 3-week period of pacing. Our findings were as follows. Plasma noradrenaline increased significantly at 1 week and increased further after 3 weeks of pacing (control, 202 ± 16; 1 week, 528 ± 62; 3 weeks, 750 ± 139 pg∙mL−1). Plasma dihydroxyphenyla

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9

Nakajima, Naoko, Syuntaro Hiradate, and Yoshiharu Fujii. "Characteristics of Growth Inhibitory Effect of L-3, 4-Dihydroxyphenylalanine (L-DOPA) on Cucumber Seedlings." Journal of Weed Science and Technology 44, no. 2 (1999): 132–38. http://dx.doi.org/10.3719/weed.44.132.

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10

Nakamura, Shinichi, Yoshio Goshima, and Yoshimi Misu. "Transmitter-like release of endogenous 3, 4-dihydroxyphenylalanine from the rat striatum investigated by microdialysis." Neuroscience Research Supplements 14 (January 1991): S147. http://dx.doi.org/10.1016/s0921-8696(06)80429-9.

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11

Visanji, N. P., S. H. Fox, T. H. Johnston, M. J. Millan та J. M. Brotchie. "α1-Adrenoceptors Mediate Dihydroxyphenylalanine-Induced Activity in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaques". Journal of Pharmacology and Experimental Therapeutics 328, № 1 (27 жовтня 2008): 276–83. http://dx.doi.org/10.1124/jpet.108.144097.

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12

Goldstein, D. S., J. Vernikos, C. Holmes, and V. A. Convertino. "Catecholaminergic effects of prolonged head-down bed rest." Journal of Applied Physiology 78, no. 3 (March 1, 1995): 1023–29. http://dx.doi.org/10.1152/jappl.1995.78.3.1023.

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Prolonged head-down bed rest (HDBR) provides a model for examining responses to chronic weightlessness in humans. Eight healthy volunteers underwent HDBR for 2 wk. Antecubital venous blood was sampled for plasma levels of catechols [norepinephrine (NE), epinephrine, dopamine, dihydroxyphenylalanine, dihydroxyphenylglycol, and dihydroxyphenylacetic acid] after supine rest on a control (C) day and after 4 h and 7 and 14 days of HDBR. Urine was collected after 2 h of supine rest during day C, 2 h before HDBR, and during the intervals 1–4, 4–24, 144–168 (day 7), and 312–336 h (day 14) of HDBR. All

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13

Shimizu, T., N. Takeda, and S. Yagi. "Levels of Biogenic Amines in the Brain during Pupal and Adult Development of the Silkworm, Bombyx mori." Zeitschrift für Naturforschung C 52, no. 3-4 (April 1, 1997): 279–82. http://dx.doi.org/10.1515/znc-1997-3-424.

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AbstractLevels of a wide range of biogenic amines and related metabolites were determined in the brain of the silk worm, Bomby mori, during pupal and adult development using a three-dimensional HPLC system with multiple coulometric electrochemical detection.In the brain of the female adults, metabolic pathways such as tyrosine (TYR-4)->dihydroxyphenylalanine (L -DOPA)-dopamine (DA), TYR-4->tyramine (TYRA), and tryptophan (TRP)->5-hydroxytryptamine (5-HT) were identified. At this stage, 3,4-dihydroxyphenyleth-ylene (DOPAC) was also detected. Metabolic pathways of biogenic amines in th

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14

Zhang, Fuping, Shuping Bi, Feng Liu, and Ningsheng Bian. "Indirect Differential Pulse Voltammetric Determination of Aluminum Biological Samples in the Presence of 3, 4-Dihydroxyphenylalanine." Analytical Letters 33, no. 2 (January 2000): 209–19. http://dx.doi.org/10.1080/00032710008543047.

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15

Nurdoğan; BOZOĞLU, TOPAL. "Determination of l-dopa (l-3, 4-dihydroxyphenylalanine) content of some faba bean (vicia faba l.) genotypes." Tarım Bilimleri Dergisi 22, no. 2 (2016): 145–51. http://dx.doi.org/10.1501/tarimbil_0000001376.

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16

Takahama, Umeo, and Takayuki Oniki. "3, 4-Dihydroxyphenylalanine is oxidized by phenoxyl radicals of hydroxycinnamic acid esters in leaves ofVicia faba L." Journal of Plant Research 111, no. 4 (December 1998): 487–94. http://dx.doi.org/10.1007/bf02507783.

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17

Kano, Yoshihiro, Fumio Otsuka, Masaya Takeda, Jiro Suzuki, Kenichi Inagaki, Tomoko Miyoshi, Manabu Miyamoto, Hiroyuki Otani, Toshio Ogura, and Hirofumi Makino. "Regulatory Roles of Bone Morphogenetic Proteins and Glucocorticoids in Catecholamine Production by Rat Pheochromocytoma Cells." Endocrinology 146, no. 12 (December 1, 2005): 5332–40. http://dx.doi.org/10.1210/en.2005-0474.

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We here report a new physiological system that governs catecholamine synthesis involving bone morphogenetic proteins (BMPs) and activin in the rat pheochromocytoma cell line, PC12. BMP type I receptors, including activin receptor-like kinase-2 (ALK-2) (also referred to as ActRIA) and ALK-3 (BMPRIA), both type II receptors, ActRII and BMPRII, as well as the ligands BMP-2, -4, and -7 and inhibin/activin subunits were expressed in PC12 cells. PC12 cells predominantly secrete dopamine, whereas noradrenaline and adrenaline production is negligible. BMP-2, -4, -6, and -7 and activin A each suppresse

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18

Takahama, Umeo, and Kunijiro Yoshitama. "Hydroxycinnamic acid esters enhance peroxidase-dependent oxidation of 3, 4-dihydroxyphenylalanine. differences in the enhancement among the esters." Journal of Plant Research 111, no. 1 (March 1998): 97–100. http://dx.doi.org/10.1007/bf02507155.

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19

Ikeda, Hitoshi, Shiro Matsuyama, Norio Suzuki, Atsushi Takahashi, and Minoru Kuroiwa. "3, 4-Dihydroxyphenylalanine (DOPA) Decarboxylase Deficiency and Resultant High Levels of Plasma DOPA and Dopamine in Unfavorable Neuroblastoma." Hypertension Research 18, SupplementI (1995): S209—S210. http://dx.doi.org/10.1291/hypres.18.supplementi_s209.

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20

Speck, Ana E., Aderbal S. Aguiar, Samira G. Ferreira, Henrique B. Silva, Ângelo R. Tomé, Paula Agostinho, Rodrigo A. Cunha, and Rui D. Prediger. "Exercise decreases aberrant corticostriatal plasticity in an animal model of l-DOPA-induced dyskinesia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320, no. 4 (April 1, 2021): R541—R546. http://dx.doi.org/10.1152/ajpregu.00295.2020.

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Physical exercise attenuates the development of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID) in 6-hydroxydopamine-induced hemiparkinsonian mice through unknown mechanisms. We now tested if exercise normalizes the aberrant corticostriatal neuroplasticity associated with experimental murine models of LID. C57BL/6 mice received two unilateral intrastriatal injections of 6-hydroxydopamine (12 μg) and were treated after 3 wk with l-DOPA/benserazide (25/12.5 mg/kg) for 4 wk, with individualized moderate-intensity running (60%–70% V̇o2peak) or not (untrained). l-DOPA converted the p

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21

Melega, William P., Milton M. Perlmutter, Andre Luxen, Charna H. K. Nissenson, Scott T. Grafton, Sung-Cheng Huang, Michael E. Phelps, and Jorge R. Barrio. "4-[18F]Fluoro-L-m-Tyrosine: An L-3,4-Dihydroxyphenylalanine Analog for Probing Presynaptic Dopaminergic Function with Positron Emission Tomography." Journal of Neurochemistry 53, no. 1 (July 1989): 311–14. http://dx.doi.org/10.1111/j.1471-4159.1989.tb07331.x.

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22

Norouzian, Dariush, Azim Akbarzadeh, Saeed Mirdamadi, Shohreh Khetami, and Ali Farhanghi. "Immobilization of Mushroom Tyrosinase by Different Methods in Order to Transform L-Tyrosine to L-3, 4 Dihydroxyphenylalanine (L-dopa)." Biotechnology(Faisalabad) 6, no. 3 (June 15, 2007): 436–39. http://dx.doi.org/10.3923/biotech.2007.436.439.

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23

Trejo-Gonzalez, Augusto, and Herlinda Soto-Valdez. "Partial Characterization of Polyphenoloxidase Extracted from `Anna' Apple." Journal of the American Society for Horticultural Science 116, no. 4 (July 1991): 672–75. http://dx.doi.org/10.21273/jashs.116.4.672.

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Polyphenoloxidase (PPO) was studied in extracts from `Anna' apples (Malus domestica Borkh.) produced under the desert conditions of the state of Sonora, Mexico. A crude extract of PPO was prepared in phosphate buffer from an acetone powder of pulp from ripe apples. Optimum conditions for enzyme activity were pH 5.36 at 35C. Specificity toward substrates, in order of decreasing activity, was 4-methylcatechol, chlorogenic acid, catechol, caffeic acid, and 3,4-dihydroxyphenylalanine. Activation energy for the reaction with 4-methylcatechoI was 6543 J·mol-1 (1563 cal·mol-1). The PPO from `Anna' wa

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24

Fukushima, Akiyoshi, Hiroaki Hase, and Koshi Saito. "Further studies on the adsorption of plant phenols by synthetic polymers." Acta Societatis Botanicorum Poloniae 58, no. 4 (2014): 583–92. http://dx.doi.org/10.5586/asbp.1989.045.

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Pyrocatechol, catechol, caffeic acid, chlorogenic acid, safflor yellow A, safflor yellow B, precarthamin and carthamin were effectively adsorbed by insoluble polyvinyl-N-pyrrolidone (PVP) in a neutral buffer solution. These eight phenols also bound with Amberlite XAD resins, however, the rate was found to be far less efficient than that of PVP. The average rate of the phenol binding was calculated as following order (%): PVP (42.7), Amberlite XAD-2 (16.6), Amberlite XAD-4 (10.1), Amberlite XAD-7 (13.0), Amberlite XAD-8 (17.7). No 3,4-dihydroxyphenylalanine was adsorbed by PVP, while the O-dih

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25

Arung, Enos Tangke, Keisuke Yoshikawa, Kuniyoshi Shimizu, and Ryuichiro Kondo. "The effect of chlorophorin and its derivative on melanin biosynthesis." Holzforschung 59, no. 5 (September 1, 2005): 514–18. http://dx.doi.org/10.1515/hf.2005.085.

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Abstract By means of bioassay-guided fractionation using mushroom tyrosinase, a geranylated stilbene, chlorophorin, was characterized as the principal tyrosinase inhibitor in the heartwood of Chlorophora excelsa (Moraceae). It inhibited the oxidation of L-tyrosine and DL-3,4-dihydroxyphenylalanine (DL-DOPA) due to mushroom tyrosinase and melanin biosynthesis on B16 melanoma cells. Chlorophorin, which is a slight yellowish compound, has previously been reported as an unstable compound in light. On the basis of this finding, a chlorophorin derivative [4-(3″,7″-dimethyloctyl)-2′,3,4′,5-tetrahydro

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26

GILLY, WM F., and MARY T. LUCERO. "Behavioral Responses to Chemical Stimulation of the Olfactory Organ in the Squid Loligo Opalescens." Journal of Experimental Biology 162, no. 1 (January 1, 1992): 209–29. http://dx.doi.org/10.1242/jeb.162.1.209.

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Behavioral experiments were carried out on restrained, but otherwise fully active, squid to test the chemoreceptive capabilities of the olfactory organ. Specific chemical substances stimulated high-pressure jet escape responses when ejected from a small pipette into the area immediately around the olfactory organ. These included squid ink and L-Dopa (3,4 dihydroxyphenylalanine) as well as agents that block voltage-dependent potassium channels, such as quaternary ammonium ions and 4-aminopyridine. Experiments designed to map chemosensitivity spatially identified the olfactory organ as the recep

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Nelson, James T., Jaeheon Lee, James W. Sims, and Eric W. Schmidt. "Characterization of SafC, a Catechol 4-O-Methyltransferase Involved in Saframycin Biosynthesis." Applied and Environmental Microbiology 73, no. 11 (April 20, 2007): 3575–80. http://dx.doi.org/10.1128/aem.00011-07.

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ABSTRACT Members of the saframycin/safracin/ecteinascidin family of peptide natural products are potent antitumor agents currently under clinical development. Saframycin MX1, from Myxococcus xanthus, is synthesized by a nonribosomal peptide synthetase, SafAB, and an O-methyltransferase, SafC, although other proteins are likely involved in the pathway. SafC was overexpressed in Escherichia coli, purified to homogeneity, and assayed for its ability to methylate a variety of substrates. SafC was able to catalyze the O-methylation of catechol derivatives but not phenols. Among the substrates teste

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Pangestiningsih, TW, T. Susmiati, and H. Wijayanto. "Kandungan L-3, 4-dihydroxyphenylalanine Suatu Bahan Neuroprotektif pada Biji Koro Benguk (Mucuna pruriens) Segar, Rebus, dan Tempe (L-3,4-DIHYDROXYPHENYLALANINE CONTENT AS A NEUROPROTECTIVE MATERIAL ON FRESH, COOKED AND FERMENTED OF KORO BENGUK (MUCUNA PRURIENS) BEANS)." Jurnal Veteriner 18, no. 1 (April 12, 2017): 116–20. http://dx.doi.org/10.19087/jveteriner.2017.18.1.116.

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Barrio, Jorge R., Sung-Cheng Huang, Dan-Chu Yu, William P. Melega, Javier Quintana, Simon R. Cherry, Andrew Jacobson, Mohammad Namavari, Nagichettiar Satyamurthy, and Michael E. Phelps. "Radiofluorinated L-m-Tyrosines: New In-Vivo Probes for Central Dopamine Biochemistry." Journal of Cerebral Blood Flow & Metabolism 16, no. 4 (July 1996): 667–78. http://dx.doi.org/10.1097/00004647-199607000-00018.

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In this work, we introduce 6-[18F]fluoro-L- m-tyrosine (6-FMT) and compare its in-vivo kinetic and biochemical behaviors in monkeys and rodents with those of 4-FMT and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (DOPA) (FDOPA). These radiofluorinated m-tyrosine presynaptic dopaminergic probes, resistant to peripheral 3- O-methylation, offer a nonpharmacological alternative to the use of catechol- O-methyltransferase inhibitors. Like FDOPA, 4-FMT and 6-FMT are analogs that essentially follow the L-DOPA pathway of central metabolism. After i.v. administration in nonhuman primates and rodents, the

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Kim, Jang Hoon, Sunggun Lee, Saerom Park, Ji Soo Park, Young Ho Kim, and Seo Young Yang. "Slow-Binding Inhibition of Tyrosinase by Ecklonia cava Phlorotannins." Marine Drugs 17, no. 6 (June 16, 2019): 359. http://dx.doi.org/10.3390/md17060359.

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Tyrosinase inhibitors improve skin whitening by inhibiting the formation of melanin precursors in the skin. The inhibitory activity of seven phlorotannins (1–7), triphlorethol A (1), eckol (2), 2-phloroeckol (3), phlorofucofuroeckol A (4), 2-O-(2,4,6-trihydroxyphenyl)-6,6′-bieckol (5), 6,8′-bieckol (6), and 8,8′-bieckol (7), from Ecklonia cava was tested against tyrosinase, which converts tyrosine into dihydroxyphenylalanine. Compounds 3 and 5 had IC50 values of 7.0 ± 0.2 and 8.8 ± 0.1 μM, respectively, in competitive mode, with Ki values of 8.2 ± 1.1 and 5.8 ± 0.8 μM. Both compounds showed th

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Bozoğlu, Hatice, and Merve Bezmen. "Determination of the L-DOPA (L-3, 4-Dihydroxyphenylalanine) Content in Faba Bean (Vicia faba L.) Flowers and Faba Bean Flower Tea." Turkish Journal of Agriculture - Food Science and Technology 9, no. 4 (April 24, 2021): 733–39. http://dx.doi.org/10.24925/turjaf.v9i4.733-739.4078.

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This study aimed to determine the L-DOPA content in the flowers of some different faba bean genotypes and determine the L-DOPA levels in tea prepared from flowers. The experiment was carried out under the ecological conditions in Samsun by the Black Sea with 15 genotypes using a randomized complete block design in three replications. The flowers were harvested three times and the number of flowers and flower yields were determined. The L-DOPA content of the flower and flower tea were determined using HPLC. Different solvents were used to extract the L-DOPA from the faba bean flowers. As a resu

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Giuri, Demetra, Nicola Zanna, and Claudia Tomasini. "Low Molecular Weight Gelators Based on Functionalized l-Dopa Promote Organogels Formation." Gels 5, no. 2 (May 14, 2019): 27. http://dx.doi.org/10.3390/gels5020027.

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We prepared the small pseudopeptide Lau-l-Dopa(OBn)2-d-Oxd-OBn (Lau = lauric acid; l-Dopa = l-3,4-dihydroxyphenylalanine; d-Oxd = (4R,5S)-4-methyl-5-carboxyl-oxazolidin-2-one; Bn = benzyl) through a number of coupling reactions between lauric acid, protected l-Dopa and d-Oxd with an excellent overall yield. The ability of the product to form supramolecular organogels has been tested with different organic solvents of increasing polarity and compared with the results obtained with the small pseudopeptide Fmoc-l-Dopa(OBn)2-d-Oxd-OBn. The mechanical and rheological properties of the organogels de

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Chen, Shuang Kou, Jian Fang Zhu, Wen Zhang Huang, Bai He, Li Jun Xiang, and Tai Gang Zhou. "Research Progress on Adhesion Mechanism of Marine Organism." Advanced Materials Research 781-784 (September 2013): 840–46. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.840.

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Marine adhesion organism includes biological mucosa such as marine bacteria, diatom, etc. and large adhesion organism such as mussel, barnacle, etc. Researches and analysis on adhesion mechanism of adhesion organism show that adhesion marine bacteria in biological mucosa will secrete protein-containing Polysaccharide polymer (PAVE) which can adhere to all kinds of surfaces. The reason is that in these secretions there is 3, 4-dihydroxyphenylalanine (DOPA) which is very viscous. Analysis on mussel, a large adhesion organism, shows that it is of super viscosity, which may result from its special

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Holten-Andersen, N., and J. H. Waite. "Mussel-designed Protective Coatings for Compliant Substrates." Journal of Dental Research 87, no. 8 (August 2008): 701–9. http://dx.doi.org/10.1177/154405910808700808.

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The byssus of marine mussels has attracted attention as a paradigm of strong and versatile underwater adhesion. As the first of the 3,4-dihydroxyphenylalanine (Dopa)-containing byssal precursors to be purified, Mytilus edulis foot protein-1 (mefp-1) has been much investigated with respect to its molecular structure, physical properties, and adsorption to surfaces. Although mefp-1 undoubtedly contributes to the durability of byssus, it is not directly involved in adhesion. Rather, it provides a robust coating that is 4–5 times stiffer and harder than the byssal collagens that it covers. Protect

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Grossman, Ehud, Aaron Hoffman, Peter C. Chang, Harry R. Keiser, and David S. Goldstein. "Increased spillover of dopa into arterial blood during dietary salt loading." Clinical Science 78, no. 4 (April 1, 1990): 423–29. http://dx.doi.org/10.1042/cs0780423.

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1. We measured urinary excretion rates of dopamine (3,4-dihydroxyphenethylamine) and dopa (3,4-dihydroxyphenylalanine) and the spillover rate of dopa into arterial blood during dietary salt loading in conscious Dahl salt-sensitive and salt-resistant rats with intact or denervated kidneys. 2. Dopa spillover was calculated from the steady-state clearance of intravenously infused l-[3H]dopa and arterial levels of endogenous dopa. 3. Daily excretion rates of dopa and dopamine increased by about sixfold during salt loading in both rat strains. Bilateral renal denervation delayed these increases and

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Jaiwal, Ranjana, and C. M. Chaturvedi. "Four Hour Temporal Relation of 5-HTP and L-DOPA Induces Inhibitory Responses in Recrudescing Gonad of Indian Palm Squirrel (Funambulus pennantii)." ISRN Endocrinology 2013 (July 1, 2013): 1–5. http://dx.doi.org/10.1155/2013/206876.

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Daily injections of L-dihydroxyphenylalanine (L-DOPA, dopamine precursor) given 4 h after 5-hydroxytryptophan (5-HTP, serotonin precursor) induced inhibitory responses in recrudescing gonad (in the first week of December) of Indian palm squirrel, a seasonally breeding subtropical animal. Other temporal relations (L-DOPA given at 0, 8, 12, 16, and 20 h after 5-HTP administration) did not show any effect on the recrudescing gonad. This inhibitory effect of 4 h was evident under short day length (6 : 18) group but was masked by the increasing day length of nature (NDL, late December onwards) and

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Hsu, Albert, Daniel M. Togasaki, Erwan Bezard, Pierre Sokoloff, J. William Langston, Donato A. Di Monte, and Maryka Quik. "Effect of the D3 Dopamine Receptor Partial Agonist BP897 [N-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on l-3,4-Dihydroxyphenylalanine-Induced Dyskinesias and Parkinsonism in Squirrel Monkeys." Journal of Pharmacology and Experimental Therapeutics 311, no. 2 (June 29, 2004): 770–77. http://dx.doi.org/10.1124/jpet.104.071142.

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Bräutigam, Christa, Ron A. Wevers, Riet J. T. Jansen, Jan A. M. Smeitink, Johanneke F. de Rijk-van Andel, Fons J. M. Gabreëls, and Georg F. Hoffmann. "Biochemical hallmarks of tyrosine hydroxylase deficiency." Clinical Chemistry 44, no. 9 (September 1, 1998): 1897–904. http://dx.doi.org/10.1093/clinchem/44.9.1897.

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Abstract We report the biochemical hallmarks of tyrosine hydroxylase deficiency with emphasis on reliable diagnostic strategies of four new cases of an inborn error of tyrosine hydroxylase (TH). Three of our patients from different parts of the Netherlands were found homozygous for a mutation in exon 6 (G698A) of the TH gene, and one patient was found compound heterozygous for the same mutation and an additional mutation in exon 3. The first clinical symptoms of hypokinesia, rigidity of arms and legs and axial hypotonia, developed between 3 and 7 months of age. Cerebrospinal fluid investigatio

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Huot, Philippe, Tom H. Johnston, Tessa Snoeren, James B. Koprich, Michael P. Hill, Susan H. Fox, and Jonathan M. Brotchie. "Use of catechol-O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque." European Journal of Neuroscience 37, no. 5 (January 3, 2013): 831–38. http://dx.doi.org/10.1111/ejn.12093.

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Goldstein, David S., Robin Stull, Graeme Eisenhofer, and John R. Gill. "Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans." Clinical Science 76, no. 5 (May 1, 1989): 517–22. http://dx.doi.org/10.1042/cs0760517.

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1. Urinary excretion of dopamine (DA) increases during dietary salt loading. The majority of urinary DA is derived from circulating dihydroxyphenylalanine (dopa). Whether the increase in urinary DA excretion during salt loading results from increased efficiency of uptake of dopa by proximal tubular cells of the kidney, facilitation of intracellular conversion of dopa to DA, or increased delivery of dopa to tubular uptake sites, has been unknown. 2. In 10 inpatient normal volunteers on a constant diet, daily excretion of dopa and DA was assessed during normal sodium intake (109 mmol/day) for 1

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Rubira, Rafael Jesus Gonçalves, Sabrina Alessio Camacho, Cibely Silva Martin, Jorge Ricardo Mejía-Salazar, Faustino Reyes Gómez, Robson Rosa da Silva, Osvaldo Novais de Oliveira Junior, Priscila Alessio, and Carlos José Leopoldo Constantino. "Designing Silver Nanoparticles for Detecting Levodopa (3,4-Dihydroxyphenylalanine, L-Dopa) Using Surface-Enhanced Raman Scattering (SERS)." Sensors 20, no. 1 (December 18, 2019): 15. http://dx.doi.org/10.3390/s20010015.

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Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson’s disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spect

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Hurley, M. J., P. H. Patel, M. J. Jackson, L. A. Smith, S. Rose, and P. Jenner. "Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with l-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia." European Journal of Neuroscience 26, no. 1 (July 3, 2007): 171–77. http://dx.doi.org/10.1111/j.1460-9568.2007.05638.x.

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Grossman, Ehud, Aaron Hoffman, Ines Armando, Zaid Abassi, Irwin J. Kopin, and David S. Goldstein. "Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats." Clinical Science 83, no. 1 (July 1, 1992): 65–74. http://dx.doi.org/10.1042/cs0830065.

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1. To determine the sources of dopa (3,4-dihydroxyphenylalanine) in plasma, we measured regional arteriovenous differences, tissue concentrations and urinary excretion of dopa during systemic intravenous infusions of I-[3H]dopa into anaesthetized intact rats and rats pretreated with the sympathetic neurotoxin, 6-hydroxydopamine. 2. In intact rats, large arteriovenous increments in plasma dopa concentrations were noted in the femoral (47%) and adrenal (141%) beds, with a small arterial-portal venous increment (11%), whereas in the kidney there was a substantial (47%) arteriovenous decrement in

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Morosanova, Maria A., Tatyana V. Fedorova, Alexandra S. Polyakova, and Elena I. Morosanova. "Agaricus bisporus Crude Extract: Characterization and Analytical Application." Molecules 25, no. 24 (December 18, 2020): 5996. http://dx.doi.org/10.3390/molecules25245996.

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In the present work crude Agaricus bisporus extract (ABE) has been prepared and characterized by its tyrosinase activity, protein composition and substrate specificity. The presence of mushroom tyrosinase (PPO3) in ABE has been confirmed using two-dimensional electrophoresis, followed by MALDI TOF/TOF MS-based analysis. GH27 alpha-glucosidases, GH47 alpha-mannosidases, GH20 hexosaminidases, and alkaline phosphatases have been also detected in ABE. ABE substrate specificity has been studied using 19 phenolic compounds: polyphenols (catechol, gallic, caffeic, chlorogenic, and ferulic acids, quer

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Baines, A. D., P. Ho, and R. Drangova. "Proximal tubular dopamine production regulates basolateral Na-K-ATPase." American Journal of Physiology-Renal Physiology 262, no. 4 (April 1, 1992): F566—F571. http://dx.doi.org/10.1152/ajprenal.1992.262.4.f566.

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Regulation of proximal tubular Na-K-adenosine-triphosphatase (ATPase), brush-border membrane Na(+)-H+ antiporter and Na(+)-Pi symporter activity by endogenously produced dopamine was examined in Wistar rats. Na-K-ATPase was measured in basolateral membrane (BLM) fractions permeabilized with alamethicin or sodium dodecyl sulfate (SDS). Carbidopa (5 mg/kg) injected 18 h before removal of kidneys increased maximal activity (Vmax) noncompetitively in cortical BLM but not in other membrane fractions or outer medullary BLM (-2 +/- 4%). Chronic renal denervation did not alter the response. Carbidopa

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Nicoletti, Ferdinando, Ingrid Philippens, Paolo Fagone, Clarence N. Ahlem, Christopher L. Reading, James M. Frincke та Dominick L. Auci. "17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease". Parkinson's Disease 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/969418.

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17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson’s disease (PD). We found that HE3286 freely penetrated the BBB. HE3286 treatment significantly improved motor function compared to vehicle in the rotarod test (mean 58.2 sec versus 90.9 sec,P<0.0001), and reduced inflammatory mediator gene expression in the brain (indu

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Esler, M. D., A. G. Turner, D. M. Kaye, J. M. Thompson, B. A. Kingwell, M. Morris, G. W. Lambert, G. L. Jennings, H. S. Cox, and D. R. Seals. "Aging effects on human sympathetic neuronal function." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 1 (January 1, 1995): R278—R285. http://dx.doi.org/10.1152/ajpregu.1995.268.1.r278.

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To study the effect of aging on human sympathetic nervous function, we applied kinetic methods for measuring the fluxes to plasma of neurochemicals relevant to sympathetic neurotransmission in younger (aged 20-30 yr) and older (aged 60-75 yr) healthy men. Mean plasma norepinephrine concentration was 66% higher in older men, attributable to 22% lower norepinephrine plasma clearance (P < 0.05) and 29% higher norepinephrine spillover to plasma (difference not statistically significant). Regional venous sampling disclosed that sympathetic outflow to all organs was not activated by aging. Renal

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Eldrup, Ebbe, Svend Erik Møller, JAN Andreasen, and Niels Juel Christensen. "Effects of Ordinary Meals on Plasma Concentrations of 3,4-Dihydroxyphenylalanine, Dopamine Sulphate and 3,4-Dihydroxyphenylacetic Acid." Clinical Science 92, no. 4 (April 1, 1997): 423–30. http://dx.doi.org/10.1042/cs0920423.

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1. Plasma concentrations of 3,4-dihydroxyphenylalanine (DOPA), dopamine sulphate (DA-S), and 3,4-dihydroxyphenylacetic acid (DOPAC) in humans have been claimed to be indexes of sympathetic nervous activity, but the source and significance of plasma DOPA, DOPAC and DA-S have not been completely elucidated. 2. The effects of ordinary meals on plasma concentrations of total dopamine, mainly DA-S, DOPAC and DOPA were studied in seven healthy subjects. Venous blood was collected every hour for 25 h, while subjects were either fasting or received three meals at 9.00 hours, 13.00 hours and 18.00 hour

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Foster, Steven B., Monika Z. Wrona, Jilin Han, and Glenn Dryhurst. "The Parkinsonian Neurotoxin 1-Methyl-4-Phenylpyridinium (MPP+) Mediates Release ofl-3,4-Dihydroxyphenylalanine (l-DOPA) and Inhibition ofl-DOPA Decarboxylase in the Rat Striatum: A Microdialysis Study." Chemical Research in Toxicology 16, no. 10 (October 2003): 1372–84. http://dx.doi.org/10.1021/tx030015l.

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Rosenblad, Carl, Qin Li, Elsa Y. Pioli, Sandra Dovero, André SLM Antunes, Leticia Agúndez, Martino Bardelli, et al. "Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson’s disease." Brain 142, no. 8 (June 26, 2019): 2402–16. http://dx.doi.org/10.1093/brain/awz176.

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Abstract Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson’s disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuations and troublesome dyskinetic side effects. These side effects, which are caused by the excessive swings in striatal dopamine caused by intermittent oral delivery, can be avoided by delivering l-DOPA in a more continuous manner. Local gene delivery of the l-DOPA synthesizing enzymes, tyrosi

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