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Artykuły w czasopismach na temat „ACE”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Sapak, Z., A. N. Mohd Faisol Mahadeven, Nurul Farhana M.H., Norsahira S., and Mohd Zafri A.W. "A review of common diseases of pineapple: the causal pathogens, disease symptoms, and available control measures." Food Research 5, S4 (2021): 1–14. http://dx.doi.org/10.26656/fr.2017.5(s4).004.

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Pineapple is a perennial fruit-bearing tropical plant that belongs to the Bromeliaceae family, which has more than 2500 species. Pineapple is known excellent source of minerals and vitamins. It produces substantial calcium, potassium, glucose, the proteindigesting enzyme bromelain, fibre, vitamin A, B and C. In Malaysia, twelve registered varieties of pineapple have been introduced and commercially planted such as Moris (AC1), Sarawak (AC2), Gandul (AC3), Maspine (AC4), Josapine (AC5) Yankee (AC6) Moris Gajah (AC7), N36 (AC8), MD2 (AC9), View of Sunset (AC10), Madu Kaca (AC11), and Keningau Di

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Alam, Md Amirul, Abdul Shukor Juraimi, M. Y. Rafii, Azizah Abdul Hamid, and Farzad Aslani. "Screening of Purslane (Portulaca oleraceaL.) Accessions for High Salt Tolerance." Scientific World Journal 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/627916.

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Purslane (Portulaca oleraceaL.) is an herbaceous leafy vegetable crop, comparatively more salt-tolerant than any other vegetables with high antioxidants, minerals, and vitamins. Salt-tolerant crop variety development is of importance due to inadequate cultivable land and escalating salinity together with population pressure. In this view a total of 25 purslane accessions were initially selected from 45 collected purslane accessions based on better growth performance and subjected to 5 different salinity levels, that is, 0.0, 10.0, 20.0, 30.0, and 40.0 dS m−1NaCl. Plant height, number of leaves

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Alhidayatullah, Alhidayatullah, A. Alfiana Putri Aziz, and Dwi Fitrah Wahyuni. "Aktivitas Antimikroba Actinomycetes Hasil Isolasi Sedimen Mangrove Asal Kecamatan Bontoa Terhadap Sreptococcus mutans." Organisms: Journal of Biosciences 2, no. 2 (2022): 95–100. http://dx.doi.org/10.24042/organisms.v2i2.14263.

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Mangroves are one of the ecosystems that are rich in nutrients and contain a lot of organic matter used by microorganisms such as actinomycetes. Actinomycetes are gram-positive bacteria capable of producing bioactive compounds. Actinomycetes are microorganisms that produce secondary metabolites that have biological activity as antimicrobials. The purpose of this study was to determine whether there are actinomycetes in Bontoa District and the potential for actinomycetes in Bontoa District which have antibacterial activity against Streptococcus mutans. Isolation of actinomycetes was carried out

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Jourdan, Karen B., Nicola A. Mason, Lu Long, Peter G. Philips, Martin R. Wilkins, and Nicholas W. Morrell. "Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 6 (2001): L1359—L1369. http://dx.doi.org/10.1152/ajplung.2001.280.6.l1359.

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Activation of adenylyl cyclase (AC), of which there are 10 diversely regulated isoforms, is important in regulating pulmonary vascular tone and remodeling. Immunohistochemistry in rat lungs demonstrated that AC2, AC3, and AC5/6 predominated in vascular and bronchial smooth muscle. Isoforms 1, 4, 7, and 8 localized to the bronchial epithelium. Exposure of animals to hypoxia did not change the pattern of isoform expression. RT-PCR confirmed mRNA expression of AC2, AC3, AC5, and AC6 and demonstrated AC7 and AC8 transcripts in smooth muscle. Western blotting confirmed the presence of AC2, AC3, and

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Long, Qi, Ming-Hui Sun, Xiao-Xue Fan, et al. "First Identification and Investigation of piRNAs in the Larval Gut of the Asian Honeybee, Apis cerana." Insects 14, no. 1 (2022): 16. http://dx.doi.org/10.3390/insects14010016.

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Piwi-interacting RNAs (piRNAs), a class of small non-coding RNAs (ncRNAs), play pivotal roles in maintaining the genomic stability and modulating biological processes such as growth and development via the regulation of gene expression. However, the piRNAs in the Asian honeybee (Apis cerana) are still largely unknown at present. In this current work, on the basis of previously gained high-quality small RNA-seq datasets, piRNAs in the larval gut of Apis cerana cerana, the nominated species of A. cerana, were identified for the first time, followed by an in-depth investigation of the regulatory

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Yang, Jin, Xuhui Feng, Qiong Zhou, et al. "Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex." Proceedings of the National Academy of Sciences 113, no. 38 (2016): E5628—E5635. http://dx.doi.org/10.1073/pnas.1525078113.

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Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac hypertrophy and fibrosis. The regulatory mechanism that underlies the Ace2-to-Ace pathological switch, however, is unknown. Here we report that the Brahma-related gene-1 (Brg1) chromatin remodeler and forkhead box M1 (FoxM1) transcription factor cooperate within cardiac (coronary) endothelial cells of pathologically stressed hearts to trigger the Ac

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Lv, Yunyun, Yanping Li, Yunhai Yi, Lijun Zhang, Qiong Shi, and Jian Yang. "A Genomic Survey of Angiotensin-Converting Enzymes Provides Novel Insights into Their Molecular Evolution in Vertebrates." Molecules 23, no. 11 (2018): 2923. http://dx.doi.org/10.3390/molecules23112923.

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Angiotensin-converting enzymes, ACE and ACE2, are two main elements in the renin–angiotensin system, with a crucial role in the regulation of blood pressure in vertebrates. Previous studies paid much attention to their physiological functions in model organisms, whereas the studies on other animals and related evolution have been sparse. Our present study performed a comprehensive genomic investigation on ace and ace2 genes in vertebrates. We successfully extracted the nucleotide sequences of ace and ace2 genes from high-quality genome assemblies of 36 representative vertebrates. After constru

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Strait, Kevin A., Peter K. Stricklett, Mark Chapman, and Donald E. Kohan. "Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse." American Journal of Physiology-Renal Physiology 298, no. 4 (2010): F859—F867. http://dx.doi.org/10.1152/ajprenal.00109.2009.

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Little is known about collecting duct adenylyl cyclase (AC) isoforms or regulation in the mouse. We performed RT-PCR for AC isoforms 1–9 in microdissected cortical (CCD) and outer medullary (OMCD) and acutely isolated inner medullary (IMCD) collecting duct. All collecting duct regions contained AC3, AC4, and AC6 mRNA, while CCD and OMCD, but not IMCD, also contained AC5 mRNA. Acutely isolated IMCD expressed AC3, AC4, and AC6 proteins by Western blot analysis. The mIMCD3 cell line expressed AC2, AC3, AC4, AC5, and AC6 mRNA; M-1 CCD cells expressed AC2, 3, 4, and 6, while mpkCCD cell lines conta

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Zhang, Ruifeng, Yingli Wu, Meng Zhao та ін. "Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells". American Journal of Physiology-Lung Cellular and Molecular Physiology 297, № 4 (2009): L631—L640. http://dx.doi.org/10.1152/ajplung.90415.2008.

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Angiotensin-converting enzyme (ACE) enhances the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), which contribute to the pathogenesis of hypoxic pulmonary hypertension (HPH). Previous reports have demonstrated that hypoxia upregulates ACE expression, but the underlying mechanism is unknown. Here, we found that ACE is persistently upregulated in PASMCs on the transcriptional level during hypoxia. Hypoxia-inducible factor 1α (HIF-1α), a key transcription factor activated during hypoxia, was able to upregulate ACE protein expression under normoxia, whereas knockdown

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Soós, B., M. Fagyas, Á. Horváth, et al. "AB0062 ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN ANTI-TNF-TREATED RHEUMATOID ARTHRITIS AND ANKYLOSING SPONDYLITIS PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1164.1–1164. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1001.

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BackgroundAngiotensin-converting enzyme (ACE) and ACE2 have been implicated in the regulation of vascular physiology. Elevated synovial and decreased or normal ACE or ACE2 levels have been found in rheumatoid arthritis (RA). Very little is known about the effects of tumour necrosis factor α (TNF-α) inhibition on ACE or ACE2 homeostasis.ObjectivesIn this study, we assessed the effects of one-year anti-TNF therapy on ACE and ACE2 production in RA and ankylosing spondylitis (AS) in association with other biomarkers.MethodsForty patients including 24 RA patients treated with either etanercept (ETN

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11

Herath, Chandana B., John S. Lubel, Zhiyuan Jia, et al. "Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2." American Journal of Physiology-Gastrointestinal and Liver Physiology 297, no. 1 (2009): G98—G106. http://dx.doi.org/10.1152/ajpgi.00045.2009.

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Angiotensin converting enzyme (ACE) 2 activity and angiotensin-(1-7) [Ang-(1-7)] levels are increased in experimental cirrhosis; however, the pathways of hepatic Ang-(1-7) production have not been studied. This study investigated the role of ACE2, ACE, and neutral endopeptidase (NEP) in the hepatic formation of Ang-(1-7) from angiotensin I (Ang I) and Ang II and their effects on portal resistance. Ang I or Ang II were administered to rat bile duct ligated (BDL) and control livers alone and in combination with the ACE inhibitor lisinopril, the ACE and NEP inhibitor omapatrilat, or the ACE2 inhi

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Afifah, Nisa Nur, Yani Mulyani, and Ari Yuniarto. "Review: Pengaruh Tanaman Obat Yang Beraktivitas Hipertensi Terhadap Ekspresi Gen Reseptor ACE-1 dan ACE 2." Jurnal Mandala Pharmacon Indonesia 7, no. 1 (2021): 9–31. http://dx.doi.org/10.35311/jmpi.v7i1.64.

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Hipertensi adalah salah satu penyakit dengan angka kesakitan dan kematian yang terus meningkat, termasuk di Indonesia. Dalam mengatasi hipertensi obat-obatan seperti ACE inhibitor berperan dalam menurunkan tekanan darah diastol dan sistol, namun tanaman obat seperti ekstrak buah hawthorn, buah zaitun (Olea europaea L.), Hibiscus Sabdariffa, Allium Sativum dan Allium Cepa juga memiliki efek sebagai antihipertensi dengan harga yang relatif murah, mudah didapat, efek samping yang lebih rendah dibandingkan dengan obat sintesis atau kimia lainnya. Review jurnal ini ditujukan untuk mengetahui berbag

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Alam, Md Amirul, Abdul Shukor Juraimi, M. Y. Rafii, and Azizah Abdul Hamid. "Effect of Salinity on Biomass Yield and Physiological and Stem-Root Anatomical Characteristics of Purslane (Portulaca oleraceaL.) Accessions." BioMed Research International 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/105695.

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13 selected purslane accessions were subjected to five salinity levels 0, 8, 16, 24, and 32 dS m−1. Salinity effect was evaluated on the basis of biomass yield reduction, physiological attributes, and stem-root anatomical changes. Aggravated salinity stress caused significant (P<0.05) reduction in all measured parameters and the highest salinity showed more detrimental effect compared to control as well as lower salinity levels. The fresh and dry matter production was found to increase in Ac1, Ac9, and Ac13 from lower to higher salinity levels but others were badly affected. Considering sal

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Soler, María José, Minghao Ye, Jan Wysocki, Josette William, Josep Lloveras, and Daniel Batlle. "Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan." American Journal of Physiology-Renal Physiology 296, no. 2 (2009): F398—F405. http://dx.doi.org/10.1152/ajprenal.90488.2008.

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Angiotensin-converting enzyme (ACE)2 is a carboxypeptidase that degrades angiotensin II and other peptides. In the kidney, ACE2 localization within the glomerulus and tubules is cell specific. This study was aimed to investigate the localization of ACE2 within the renal vasculature. We also studied the effect of the administration of a specific angiotensin II type 1 receptor blocker, telmisartan, on ACE2 expression in the renal vasculature. ACE2 and ACE were localized in renal arterioles using confocal microscopy and specific cell markers. Quantitative measurements of ACE2 and ACE mRNA were es

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AL-Eitan, Laith, Sara Al-Khaldi, and Rasheed k. Ibdah. "ACE gene polymorphism and susceptibility to hypertension in a Jordanian adult population." PLOS ONE 19, no. 6 (2024): e0304271. http://dx.doi.org/10.1371/journal.pone.0304271.

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Hypertension is one of the most common and complicated disorders associated with genetic and environmental risk factors. The angiotensin-converting enzyme (ACE) is important in the renin-angiotensin-system pathway. The gene expression of ACE has been investigated as a possible hypertension marker. This study investigates the association between polymorphisms within the ACE1 and ACE2 genes and hypertension susceptibility in a Jordanian population. The study comprised a total of 200 hypertensive patients and 180 healthy controls. A polymerase chain reaction (PCR) was performed to genotype the ca

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Hariyanto, Timotius Ivan, Karunia Valeriani Japar, Vika Damay, Felix Kwenandar, Novia Lauren Sieto, and Andree Kurniawan. "The Use of ACE inhibitor/ARB in SARS-CoV-2 Patients: A Comprehensive Narrative Review." Asian Journal of Medical Sciences 11, no. 6 (2020): 113–20. http://dx.doi.org/10.3126/ajms.v11i6.29911.

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The three most common comorbidities that are associated with increased mortality in COVID-19 patients are Hypertension, Diabetes, and Cardiovascular disease, Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor blockers (ARB) are the drugs most commonly prescribed for the management of these diseases. Recent experimental study in animals and humans have found that SARS-CoV-2 uses ACE2 as the receptors for entry. Moreover, in an animal study, the use of ACE inhibitor/ARB increases the level of ACE2 expression that can lead to increased SARS-CoV-2 infectivity. On the other

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Timotius Ivan Hariyanto, Karunia Valeriani Japar, Vika Damay, Felix Kwenandar, Novia Lauren Sieto, and Andree Kurniawan. "The Use of ACE inhibitor/ARB in SARS-CoV-2 Patients: A Comprehensive Narrative Review." Asian Journal of Medical Sciences 11, no. 6 (2020): 113–20. https://doi.org/10.71152/ajms.v11i6.3942.

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The three most common comorbidities that are associated with increased mortality in COVID-19 patients are Hypertension, Diabetes, and Cardiovascular disease, Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor blockers (ARB) are the drugs most commonly prescribed for the management of these diseases. Recent experimental study in animals and humans have found that SARS-CoV-2 uses ACE2 as the receptors for entry. Moreover, in an animal study, the use of ACE inhibitor/ARB increases the level of ACE2 expression that can lead to increased SARS-CoV-2 infectivity. On the other

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RICE, Gillian I., Daniel A. THOMAS, Peter J. GRANT, Anthony J. TURNER, and Nigel M. HOOPER. "Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism." Biochemical Journal 383, no. 1 (2004): 45–51. http://dx.doi.org/10.1042/bj20040634.

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In the RAS (renin–angiotensin system), Ang I (angiotensin I) is cleaved by ACE (angiotensin-converting enzyme) to form Ang II (angiotensin II), which has effects on blood pressure, fluid and electrolyte homoeostasis. We have examined the kinetics of angiotensin peptide cleavage by full-length human ACE, the separate N- and C-domains of ACE, the homologue of ACE, ACE2, and NEP (neprilysin). The activity of the enzyme preparations was determined by active-site titrations using competitive tight-binding inhibitors and fluorogenic substrates. Ang I was effectively cleaved by NEP to Ang (1–7) (kcat

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Kar, Sumit, Lie Gao, and Irving H. Zucker. "Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure." Journal of Applied Physiology 108, no. 4 (2010): 923–32. http://dx.doi.org/10.1152/japplphysiol.00840.2009.

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Exercise training (EX) normalizes sympathetic outflow and plasma ANG II in chronic heart failure (CHF). The central mechanisms by which EX reduces this sympathoexcitatory state are unclear, but EX may alter components of the brain renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE) may mediate an increase in sympathetic nerve activity (SNA). ACE2 metabolizes ANG II to ANG-(1–7), which may have antagonistic effects to ANG II. Little is known concerning the regulation of ACE and ACE2 in the brain and the effect of EX on these enzymes, especially in the CHF state. This study aimed

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Badaras, Ignas, and Agnė Laučyė-Cibulskienė. "COVID-19 POVEIKIS ENDOTELIUI." Health Sciences 5, no. 32 (2022): 113–15. http://dx.doi.org/10.35988/sm-hs.2022.204.

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Neseniai buvo iškelta idėja, kad COVID-19 gali būti laikoma endotelio liga. SARS-CoV- 2 patenka į ląsteles, naudodamas S baltymą, kuris atpažįsta angiotenziną konvertuojantį fermentą- 2 (angl. angiotensine-converting enzyme, ACE2). ACE2 randami epitelyje, plonosios žarnos enterocituose, arterijų miocituose ir kardiovaskulinės sistemos endotelyje. COVID-19 sukeltos endoteliopatijos lygis koreliuoja su ligos sunkumu. ACE ir ACE2 receptoriai veikia antagonistiškai. ACE2 skatina vazodilataciją, mažina uždegimą ir oksidacinį stresą. ACE veikia vazokonstriktiškai, skatina uždegimą ir oksidacinį

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Camargo Junior, Otacílio de, Luiz Roberto Felizzola, Antonio Cláudio Guedes Chrispim, et al. "Enxerto subclávio-carotídeo como método de tratamento na obstrução da artéria carótida comum." Jornal Vascular Brasileiro 9, no. 1 (2010): 78–81. http://dx.doi.org/10.1590/s1677-54492010000100014.

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A oclusão isolada da artéria carótida comum (ACC) é uma lesão relativamente incomum (0,5 a 5%). A maioria dos pacientes com obstrução da ACC tem lesão concomitante na artéria carótida interna (ACI) e na artéria carótida externa (ACE) ipsilaterais, sendo que, ocasionalmente, a circulação colateral da ACE pode preservar a perviedade da ACI via fluxo retrógrado. Relatamos o caso de um paciente sintomático com oclusão da ACC e perviedade das ACI e ACE tratado cirurgicamente com enxerto subclávio-carotídeo.

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Esteves-Monteiro, Marisa, Cláudia Vitorino-Oliveira, Joana Castanheira-Moreira, et al. "Differential Effects of Losartan and Finerenone on Diabetic Remodeling, Oxidative Stress and ACE Activity in the Gastrointestinal Tract of Streptozotocin-Induced Diabetic Rats." International Journal of Molecular Sciences 26, no. 13 (2025): 6294. https://doi.org/10.3390/ijms26136294.

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Gastrointestinal (GI) complications are common in diabetes, but the role of the local renin-angiotensin-aldosterone system (RAAS) in gut remodeling remains unclear. This study examined histomorphometric alterations, oxidative stress, and systemic and tissue-specific angiotensin converting enzyme (ACE) and ACE2 activity in streptozotocin (STZ)-induced diabetic rats. Adult male Wistar rats (n = 24) were assigned to control (CTRL), diabetic (STZ), and diabetic groups treated with losartan (STZ-LOS, 20 mg/kg/day) or finerenone (STZ-FIN, 10 mg/kg/day). After 14 days, gut samples were collected from

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Wysocki, Jan, Anne Goodling, Mar Burgaya, et al. "Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease." American Journal of Physiology-Renal Physiology 313, no. 2 (2017): F487—F494. http://dx.doi.org/10.1152/ajprenal.00074.2017.

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The pathways implicated in diabetic kidney disease (DKD) are largely derived from animal models. To examine if alterations in renin-angiotensin system (RAS) in humans are concordant with those in rodent models, we measured concentration of angiotensinogen (AOG), cathepsin D (CTSD), angiotensin-converting enzyme (ACE), and ACE2 and enzymatic activities of ACE, ACE2, and aminopeptidase-A in FVB mice 13–20 wk after treatment with streptozotocin ( n = 9) or vehicle ( n = 15) and people with long-standing type 1 diabetes, with ( n = 37) or without ( n = 81) DKD. In streptozotocin-treated mice, urin

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Li, Bing, Yan Hong Wang, Ju Mei Wang, and Wei De Shen. "Cloning and Expression Analysis of Acetylcholinesterase Gene (Bm-ace1, Bm-ace2) from Domesticated Silkworm, Bombyx mori." Advanced Materials Research 175-176 (January 2011): 13–18. http://dx.doi.org/10.4028/www.scientific.net/amr.175-176.13.

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Acetylcholinesterase (AChE, 2 EC 3.1.1.7), encoded by the ace gene, catalyzes the hydrolysis of the neurotransmitter acetylcholine to terminate nerve impulses at the postsynaptic membrane. In this study, AChE genes (Bm-ace1, Bm-ace2) were cloned from domesticated silkworm Bombyx mori (Dazao strain) through RT-PCR. Sequence analysis showed that the ORF of Bm-ace1 gene contained 2 025 bp nucleotides, encoding 683 amino acid residues. The predicted protein has a molecular weight (MW) of 76.96 kD and an isoelectric point (pI) of 6.36; The ORF of Bm-ace2 gene contained 1 917 bp nucleotides, encodin

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Canto Saenz, Francys Mitchel, Gustavo Ampuero trigoso, and Hurley Abel Quispe-Ccasa. "Efecto de la altura de corte sobre los parámetros agronómicos de Tithonia diversifolia." Revista de Investigaciones Altoandinas - Journal of High Andean Research 25, no. 2 (2023): 117–21. http://dx.doi.org/10.18271/ria.2023.518.

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Se evaluaron los parámetros agronómicos de Tithonia diversifolia por efecto de cuatro alturas de corte (AC) desde el suelo (AC1: 0 cm, AC2: 10 cm, AC3: 20 cm, AC4: 30cm), con cuatro replicas cada una, durante 55 días. Los brotes/macollo, hojas/brote y hojas/macollo fueron mayores (p<0.05) en AC1. Sin embargo, el número de hojas/mata y brotes/mata fueron mayores (p<0.05) en AC2, AC3 y AC4. El peso de forraje verde (FV)/macollo fue mayor (p<0.05) en AC1; aunque el peso de FV/mata fue mayor en AC2, AC3 y AC4, mostrando un mayor (p<0.05) rendimiento (kg/m2) en FV y materia seca para AC

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Wakahara, Shigeyuki, Tadashi Konoshita, Shinichi Mizuno, et al. "Synergistic Expression of Angiotensin-Converting Enzyme (ACE) and ACE2 in Human Renal Tissue and Confounding Effects of Hypertension on the ACE to ACE2 Ratio." Endocrinology 148, no. 5 (2007): 2453–57. http://dx.doi.org/10.1210/en.2006-1287.

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Angiotensin-converting enzyme (ACE) 2, a newly emerging component of the renin-angiotensin system, is presumed to be a counterregulator against ACE in generating and degrading angiotensin II. It remains to be elucidated how mRNA levels of these two genes are quantitatively regulated in the kidney and also what kind of clinicopathological characteristics could influence the gene expressions in humans. Seventy-eight cases of biopsy-proven renal conditions were examined in detail. Total RNA from a small part of each renal cortical biopsy specimen was reverse transcribed, and the resultant cDNA wa

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Guarienti, Fabiana Amaral, Fernando Antônio Costa Xavier, Mateus Duarte Ferraz, et al. "Are COVID-19 Polymorphisms in ACE and ACE2 Prognosis Predictors?" Current Issues in Molecular Biology 46, no. 8 (2024): 8111–17. http://dx.doi.org/10.3390/cimb46080480.

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Regardless of the containment of the SARS-CoV-2 pandemic, it remains paramount to comprehensively understand its underlying mechanisms to mitigate potential future health and economic impacts, comparable to those experienced throughout the course of the pandemic. The angiotensin-converting enzyme 2 (ACE2) provides anchorage for SARS-CoV-2 binding, thus implicating that ACE and ACE2 might contribute to the variability in infection severity. This study aimed to elucidate predisposing factors influencing the disease course among people infected by SARS-CoV-2, focusing on angiotensin-converting en

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Wallace, Arthur W., Piera M. Cirillo, James C. Ryan, Nickilou Y. Krigbaum, Anusha Badathala, and Barbara A. Cohn. "Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study." BMJ Open 11, no. 12 (2021): e050051. http://dx.doi.org/10.1136/bmjopen-2021-050051.

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ObjectivesSARS-CoV-2 enters cells using the ACE2 receptor. Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury. Here, we describe COVID-19 survival associated with ACE-I, ARB and metformin use.DesignThis is a hospital-based observational study of patients with COVID-19 infection using logistic regression with correction for pre-existing conditions and propensity score weighted Cox proportional hazards models

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Haghighi, Mahdi Montazer, Erfan Ghani Kakhki, Christine Sato, Mahdi Ghani, and Ekaterina Rogaeva. "The Intersection between COVID-19, the Gene Family of ACE2 and Alzheimer’s Disease." Neuroscience Insights 15 (January 2020): 263310552097574. http://dx.doi.org/10.1177/2633105520975743.

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We reviewed factors that might influence COVID-19 outcomes (eg, neurological symptoms), including the link to Alzheimer’s disease. Since the virus triggers COVID-19 infection through binding to ACE2, we focused on the ACE2 gene family, including ACE. Both ACE2 and ACE are involved in the renin–angiotensin system (RAS). In general, ACE causes inflammation and vasoconstriction, while ACE2 leads to anti-inflammation activity and vasodilation. The disturbed balance between these counter-regulatory pathways could influence susceptibility to COVID-19. Notably, dysregulation of the RAS-equilibrium co

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Fleming, Ingrid, Karin Kohlstedt, and Rudi Busse. "New fACEs to the Renin-Angiotensin System." Physiology 20, no. 2 (2005): 91–95. http://dx.doi.org/10.1152/physiol.00003.2005.

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Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases. Recent evidence suggests that some of the beneficial effects of ACE inhibitors can be attributed to the activation of a distinct ACE signaling cascade rather than to the changes in angiotensin II and bradykinin levels. Moreover, at least one other ACE homolog (ACE2) plays a significant role in the regulation of heart and kidney function.

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Chamata, Yara, Kim G. Jackson, Kimberly A. Watson, and Paula Jauregi. "Whey-Derived Peptides at the Heart of the COVID-19 Pandemic." International Journal of Molecular Sciences 22, no. 21 (2021): 11662. http://dx.doi.org/10.3390/ijms222111662.

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The renin–angiotensin system (RAS) is a key regulator of blood pressure and hypertension. Angiotensin-converting enzyme 2 (ACE2) and angiotensin-converting enzyme I (ACE) are two main components of the RAS that play a major role in blood pressure homeostasis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses ACE2 as a receptor to enter cells. Despite some controversies, numerous studies have reported a significant association between the use of ACE inhibitors and reduced risk of COVID-19. In our previous studies, we produced and identified peptide sequences present in whey

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Xiao, Liang, Karla K. V. Haack, and Irving H. Zucker. "Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling." American Journal of Physiology-Cell Physiology 304, no. 11 (2013): C1073—C1079. http://dx.doi.org/10.1152/ajpcell.00364.2012.

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Brain ANG II plays an important role in modulating sympathetic function and homeostasis. The generation and degradation of ANG II are carried out, to a large extent, through the angiotensin-converting enzyme (ACE) and ACE2, respectively. In disease states, such as hypertension and chronic heart failure, central expression of ACE is upregulated and ACE2 is decreased in central sympathoregulatory neurons. In this study, we determined the expression of ACE and ACE2 in response to ANG II in a neuronal cell culture and the subsequent signaling mechanism(s) involved. A mouse catecholaminergic neuron

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Li, Bing, Yan Hong Wang, Ju Mei Wang, and Wei De Shen. "Full Length cDNA Cloning and Expression Characteristics of Ace Gene from Wild Silkworm, Bombyx mandarina." Advanced Materials Research 175-176 (January 2011): 51–55. http://dx.doi.org/10.4028/www.scientific.net/amr.175-176.51.

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Acetylcholinesterase (AChE), which contains two subfamilies, ace1 and ace2 in insects, was identified to be the target of organophosphorous and carbamate insecticides. To research the sequences and tissues expressions of two aces, full length cDNAs encoding two ace genes were cloned, designated as Bmm-ace1 and Bmm-ace2 from larvae of the Bombyx mandarina. The amino acid sequence of Bmm-ace1 shared 99.71 % homology with its homolog, Bm-ace1, in silkworm, Bombyx mori, with two mutations (G664S and S307P), and the amino acid sequence of Bmm-ace2 shared 99.37 % homology with Bm-ace2, in B. mori ,

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Hooper, Nigel M., Daniel W. Lambert, and Anthony J. Turner. "Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19." Clinical Science 134, no. 18 (2020): 2489–501. http://dx.doi.org/10.1042/cs20200476.

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Abstract Angiotensin-converting enzyme (ACE) is a zinc membrane metallopeptidase that plays a key role in regulating vasoactive peptide levels and hence cardiovascular activity through its conversion of angiotensin I (Ang I) to Ang II and its metabolism of bradykinin. The discovery of its homologue, ACE2, 20 years ago has led to intensive comparisons of these two enzymes revealing surprising structural, catalytic and functional distinctions between them. ACE2 plays multiple roles not only as a vasopeptidase but also as a regulator of amino acid transport and serendipitously as a viral receptor

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Shaltout, Hossam A., Brian M. Westwood, David B. Averill, et al. "Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II." American Journal of Physiology-Renal Physiology 292, no. 1 (2007): F82—F91. http://dx.doi.org/10.1152/ajprenal.00139.2006.

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Despite the evidence that angiotensin-converting enzyme (ACE)2 is a component of the renin-angiotensin system (RAS), the influence of ACE2 on angiotensin metabolism within the kidney is not well known, particularly in experimental models other than rats or mice. Therefore, we investigated the metabolism of the angiotensins in isolated proximal tubules, urine, and serum from sheep. Radiolabeled [125I]ANG I was hydrolyzed primarily to ANG II and ANG-(1–7) by ACE and neprilysin, respectively, in sheep proximal tubules. The ACE2 product ANG-(1–9) from ANG I was not detected in the absence or prese

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Saleem, Muhammad. "Effect of Chemical Activating Agents on Surface Area and Methylene Blue Uptake Capacity of Activated Carbons." Pakistan Journal of Scientific & Industrial Research Series A: Physical Sciences 64, no. 3 (2021): 254–64. http://dx.doi.org/10.52763/pjsir.phys.sci.64.3.2021.254.264.

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Activated carbon from Acacia asak (Fabaceae) tree branches was prepared utilizing three-steps- process and H3P04, ZnCl2, H2S04, K2C03, Na0H and K0H as chemical activating agents. In addition to the elemental analysis of precursor materials, produced activated carbon (ATB-AC) was also analyzed for moisture content, ash content, pH value, bulk density, volatile matter, hardness, specific surface area (SBET), iodine number and pore volume. Results revealed that the quality of ATB-AC is well comparable to the available commercial activated carbon (CAC). The SBET was found to be in the order of ATB

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Gill, Dipender, Marios Arvanitis, Paul Carter, et al. "ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study." Royal Society Open Science 7, no. 11 (2020): 200958. http://dx.doi.org/10.1098/rsos.200958.

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Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circ

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Kamilic, Jelena, Inge Hamming, A. Titia Lely, et al. "Rat Ace allele variation determines susceptibility to AngII-induced renal damage." Journal of the Renin-Angiotensin-Aldosterone System 12, no. 4 (2011): 420–29. http://dx.doi.org/10.1177/1470320311415886.

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Introduction: Ace b/l polymorphism in rats is associated with differential tissue angiotensin-converting enzyme (ACE) expression and activity, and susceptibility to renal damage. Same polymorphism was recently found in outbred Wistar rat strain with b allele accounting for higher renal ACE, and provided a model for studying renin–angiotensin–aldosterone system (RAAS) response behind the innate high or low ACE conditions. Methods: We investigated the reaction of these alleles on chronic angiotensin II (AngII) infusion. Wistar rats were selected to breed male homozygotes for the b (WU-B) or l al

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Lubbe, Lizelle, Gyles E. Cozier, Delia Oosthuizen, K. Ravi Acharya, and Edward D. Sturrock. "ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV." Clinical Science 134, no. 21 (2020): 2851–71. http://dx.doi.org/10.1042/cs20200899.

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Abstract Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity, haematopoiesis and diseases such as obesity, fibrosis and Alzheimer’s dementia. Like ACE, the human homologue ACE2 is also involved in blood pressure regulation and cleaves a range of substrates involved in different physiological processes. Importantly, it is the functional receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 responsible for the 2020, coronavirus infectious disea

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SPLETE, HEIDI. "AACE, ACE Urge Prediabetes Focus." Clinical Endocrinology News 3, no. 8 (2008): 1–12. https://doi.org/10.1016/s1558-0164(08)70293-1.

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Cuddy, Leah K., Dmitry Prokopenko, Eric P. Cunningham та ін. "Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice". Science Translational Medicine 12, № 563 (2020): eaaz2541. http://dx.doi.org/10.1126/scitranslmed.aaz2541.

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Recent genome-wide association studies identified the angiotensin-converting enzyme gene (ACE) as an Alzheimer’s disease (AD) risk locus. However, the pathogenic mechanism by which ACE causes AD is unknown. Using whole-genome sequencing, we identified rare ACE coding variants in AD families and investigated one, ACE1 R1279Q, in knockin (KI) mice. Similar to AD, ACE1 was increased in neurons, but not microglia or astrocytes, of KI brains, which became elevated further with age. Angiotensin II (angII) and angII receptor AT1R signaling were also increased in KI brains. Autosomal dominant neurodeg

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Xu, Wenqi, Sigrid A. Langhans, David K. Johnson, et al. "Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2." International Journal of Molecular Sciences 25, no. 17 (2024): 9419. http://dx.doi.org/10.3390/ijms25179419.

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Angiotensin-converting enzymes (ACE) are well-known for their roles in both blood pressure regulation via the renin-angiotensin system as well as functions in fertility, immunity, hematopoiesis, and many others. The two main isoforms of ACE include ACE and ACE-2 (ACE2). Both isoforms have similar structures and mediate numerous effects on the cardiovascular system. Most remarkably, ACE2 serves as an entry receptor for SARS-CoV-2. Understanding the interaction between the virus and ACE2 is vital to combating the disease and preventing a similar pandemic in the future. Noninvasive imaging techni

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Prieto, Minolfa C., Romer A. González-Villalobos, Fady T. Botros, et al. "Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1–7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats." American Journal of Physiology-Renal Physiology 300, no. 3 (2011): F749—F755. http://dx.doi.org/10.1152/ajprenal.00383.2009.

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Alterations in the balance between ANG II/ACE and ANG 1–7/ACE2 in ANG II-dependent hypertension could reduce the generation of ANG 1–7 and contribute further to increased intrarenal ANG II. Upregulation of collecting duct (CD) renin may lead to increased ANG II formation during ANG II-dependent hypertension, thus contributing to this imbalance. We measured ANG I, ANG II, and ANG 1–7 contents, angiotensin-converting enzyme (ACE) and ACE2 gene expression, and renin activity in the renal cortex and medulla in the clipped kidneys (CK) and nonclipped kidneys (NCK) of 2K1C rats. After 3 wk of unilat

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Turner, Anthony J., Sarah R. Tipnis, Jodie L. Guy, Gillian I. Rice, and Nigel M. Hooper. "ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors." Canadian Journal of Physiology and Pharmacology 80, no. 4 (2002): 346–53. http://dx.doi.org/10.1139/y02-021.

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A human zinc metalloprotease (termed ACEH or ACE2) with considerable homology to angiotensin- converting enzyme (ACE) (EC 3.4.15.1) has been identified and subsequently cloned and functionally expressed. The translated protein contains an N-terminal signal sequence, a single catalytic domain with zinc-binding motif (HEMGH), a transmembrane region, and a small C-terminal cytosolic domain. Unlike somatic ACE, ACEH functions as a carboxypeptidase when acting on angiotensin I and angiotensin II or other peptide substrates. ACEH may function in conjunction with ACE and neprilysin in novel pathways

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Zhang, Xiaoqing, Shuren Li, and Shaoqian Niu. "ACE2 and COVID-19 and the resulting ARDS." Postgraduate Medical Journal 96, no. 1137 (2020): 403–7. http://dx.doi.org/10.1136/postgradmedj-2020-137935.

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This article reviews the correlation between ACE2 and COVID-19 and the resulting acute respiratory distress syndrome (ARDS). ACE2 is a crucial component of the renin-angiotensin system (RAS). The classical ACE-angiotensin Ⅱ (Ang II)-angiotensin type 1 receptor (AT1R) axis and the ACE2-Ang(1-7)-Mas counter-regulatory axis play an essential role in RAS system. ACE2 antagonises the activation of the classical RAS ACE-Ang II-AT1R axis and protects against lung injury. Similar to severe acute respiratory syndrome-related coronavirus, 2019 novel coronavirus (2019-nCoV) also uses ACE2 for cell entry.

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Tyrankiewicz, Urszula, Mariola Olkowicz, Tomasz Skórka та ін. "Activation pattern of ACE2/Ang-(1–7) and ACE/Ang II pathway in course of heart failure assessed by multiparametric MRI in vivo in Tgαq*44 mice". Journal of Applied Physiology 124, № 1 (2018): 52–65. http://dx.doi.org/10.1152/japplphysiol.00571.2017.

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Here, we analyzed systemic (plasma) and local (heart/aorta) changes in ACE/ACE-2 balance in Tgαq*44 mice in course of heart failure (HF). Tgαq*44 mice with cardiomyocyte-specific Gαq overexpression and late onset of HF were analyzed at different age for angiotensin pattern in plasma, heart, and aorta using liquid chromatography/mass spectrometry, for progression of HF by in vivo magnetic resonance imaging under isoflurane anesthesia, and for physical activity by voluntary wheel running. Six-month-old Tgαq*44 mice displayed decreased ventricle radial strains and impaired left atrial function. A

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Debasish, Paul, Kumar Dhar Dipak, and Dutta Susmita. "Brief Insight into the Physiological Perspective of Renin-Angiotensin-Aldosterone-System as a Gateway in Pathogenesis of COVID-19." International Journal of Research and Review 7, no. 7 (2020): 157–60. https://doi.org/10.5281/zenodo.3982347.

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The world is facing an unprecedented crisis due to “COVID-19” pandemic and the number of cases are constantly soaring. ACE2 is ubiquitously present in different organs including nasal epithelium, conducting airways and alveolar epithelium. It is found that S-protein of SARS-CoV-2 activated by TMPRSS2 targets ACE2 for gaining entry into host cells. Eventually the downregulation of ACE-2 occurs, either directly because of viral binding and endocytosis or indirectly because of cell lysis or ADAM17 activity. This results in homeostatic disruption of ACE/ACE2 system balance and the acti

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Bánhegyi, Viktor, Attila Enyedi, Gábor Áron Fülöp, et al. "Human Tissue Angiotensin Converting Enzyme (ACE) Activity Is Regulated by Genetic Polymorphisms, Posttranslational Modifications, Endogenous Inhibitors and Secretion in the Serum, Lungs and Heart." Cells 10, no. 7 (2021): 1708. http://dx.doi.org/10.3390/cells10071708.

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Objective: Inhibitors of the angiotensin converting enzyme (ACE) are the primarily chosen drugs to treat heart failure and hypertension. Moreover, an imbalance in tissue ACE/ACE2 activity is implicated in COVID-19. In the present study, we tested the relationships between circulating and tissue (lung and heart) ACE levels in men. Methods: Serum, lung (n = 91) and heart (n = 72) tissue samples were collected from Caucasian patients undergoing lung surgery or heart transplantation. ACE I/D genotype, ACE concentration and ACE activity were determined from serum and tissue samples. Clinical parame

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Li, Ningjun, Joseph Zimpelmann, Keding Cheng, John A. Wilkins, and Kevin D. Burns. "The role of angiotensin converting enzyme 2 in the generation of angiotensin 1–7 by rat proximal tubules." American Journal of Physiology-Renal Physiology 288, no. 2 (2005): F353—F362. http://dx.doi.org/10.1152/ajprenal.00144.2004.

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ANG converting enzyme (ACE) 2 (ACE2) is a homologue of ACE, which is not blocked by conventional ACE inhibitors. ACE2 converts ANG 1–10 (ANG I) to ANG 1–9, which can be hydrolyzed by ACE to form the biologically active peptide ANG 1–7. ACE2 is expressed in the kidney, but its precise intrarenal localization is unclear, and the role of intrarenal ACE2 in the production of ANG 1–7 is unknown. The present studies determined the relative distribution of ACE2 in the rat kidney and defined its role in the generation of ANG 1–7 in proximal tubule. In microdissected rat nephron segments, semiquantitat

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Gomes, Roberto, Andreia Febba Gomes, Mariana da Silva Martins, et al. "P137 ACE AND ACE 2 ENZYMES POLYMORPHISM IN DIFFERENT CLINICAL COVID-19 MANIFESTATIONS IN HOSPITAL-ADMITTED PATIENTS." Journal of Hypertension 42, Suppl 3 (2024): e108. http://dx.doi.org/10.1097/01.hjh.0001063420.02338.5c.

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Introduction: The affinity of SARS-CoV-2 for the Angiotensin Converting Enzyme 2 (ACE2), component of the Renin-Angiotensin System (RAS), is responsible for the COVID-19 virus internalization, and the ACE and ACE2 genes polymorphisms may contribute for the disease outcome. Objective: To correlate the I/D ACE and the G8790A ACE2 polymorphisms and their enzymatic activity to the virus susceptibility and the disease's clinical severity. Methods: 408 patients from Alfa Hospital, Recife – PE, were assessed. ACE activity was measured by fluorometry and the real time PCR technique was used to assess

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