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Artykuły w czasopismach na temat „Acid peptic disorder”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Alfahad, Mohanad, Mahmood H. M. Jasim, Mohannad E. Qazzaz, Fawaz A. Alassaf, and Mohammed N. Abed. "Proton pump inhibitors and peptic ulcer management: Antioxidant mechanisms." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 242–46. http://dx.doi.org/10.22270/jddt.v11i4-s.4955.

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Peptic ulcer (P.U.) is the gastrointestinal tract's most frequent disorder affecting mainly the stomach and duodenum. Surgical intervention, ingested materials and microbial infections may trigger inflammation that further predispose to oxidative stress. Proton pump inhibitors (PPIs) are group of compounds established for suppressions of gastric acid secretions profoundly and permanently over a reasonably long period of time. Oxidative stress has been shown to be involved in the pathophysiology of various diseases and disorders, including P.U. Particularly when H. pylori infection accompanies

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Bandana Kaur, Bandana Kaur, Parul Verma, Dr Ajeet Pal Singh, Dr Amar Pal Singh, and Kiran Bala Kiran Bala. "Peptic Ulcers: Understanding Etiology, Pathophysiology, Diagnosis, Treatment of Peptic Ulcers." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1172–84. https://doi.org/10.35629/4494-100211721184.

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Peptic ulcer disease (PUD) is a common gastrointestinal disorder characterized by acid-induced lesions in the digestive tract, predominantly affecting the stomach and the first segment of the duodenum. It results from extensive erosion of the mucosal lining, which can progress to the muscular layer due to the corrosive effects of gastric acid. PUD is classified into two main types: gastric ulcers, which occur in the stomach, and duodenal ulcers, which develop in the duodenum. The primary causes of PUD are infection with Helicobacter pylori and the use of non-steroidal anti-inflammatory drugs (

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Komal, Chavan Dr. Kavita Kulkarni Madhavi Kakphale*. "Review Article On Hyperacidity." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1192–97. https://doi.org/10.5281/zenodo.13960963.

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Hyperacidity, is refers to as the excessive stomach acid, occurs when the stomach produces an abnormal amount of acid, often leading to symptoms such as heartburn, indigestion, and gastric discomfort. Common causes include diet, stress, smoking, and certain medications. Chronic hyperacidity can result in complications like gastro-esophageal reflux disease (GERD) and peptic ulcers. Management typically involves lifestyle modifications, dietary changes, and medications like antacids, proton pump inhibitors, or H2 blockers to reduce acid production and develop symptoms. Understanding hyperacidity

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Kawaguchi, Takaki, Hiroyuki Fukazawa, Yoshihisa Naito, and Kōsuke Okada. "Dermal dysplasia characterized by collagen disorder-related skin fragility in a cow." American Journal of Veterinary Research 49, no. 6 (1988): 965–71. https://doi.org/10.2460/ajvr.1988.49.06.965.

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SUMMARY Holstein cow 1 was examined because of skin fragility and delayed healing of skin wounds, which were markedly exacerbated around the time of parturition. A skin biopsy sample was obtained, and light microscopy revealed irregular deposition of thin collagen fibers in a dermal matrix. Although diffuse inflammation did not occur, the number of plump fibroblasts was increased. Electron microscopy revealed poor construction of collagen fibrils in the dermal matrix. Biochemical analysis of the dermis revealed a normal amount of collagen and uronic acid, but sodium dodecyl sulfate-polyacrylam

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Manimekalai, K., R. Sudar Codi, Navinraja Komal Veererathinakumar, and Vimala Ananthy. "Potassium-competitive Acid Blocker: A Newer Target in the Treatment of Acid Peptic Disorder." SBV Journal of Basic, Clinical and Applied Health Science 6, no. 2 (2023): 33–38. http://dx.doi.org/10.5005/jp-journals-10082-03182.

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Singh, Karanvir, Rajesh Kumar, Ajeet Pal Singh, Meenakshi Malhotra, Amar Pal Singh, and Ritu Rani. "Peptic Ulcer: A review." International Journal of Medical, Pharmacy and Drug Research 8, no. 2 (2024): 38–46. http://dx.doi.org/10.22161/ijmpd.8.2.5.

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Peptic ulcers, characterized by painful sores that develop on the lining of the stomach, small intestine, or esophagus, are a prevalent gastrointestinal condition affecting millions worldwide. This abstract provides an overview of the causes, symptoms, and treatment options for peptic ulcers. Peptic ulcers primarily stem from the imbalance between aggressive factors such as gastric acid secretion, pepsin, and Helicobacter pylori infection, and defensive mechanisms like mucosal barrier integrity and blood flow. Lifestyle factors such as excessive alcohol consumption, smoking, and stress, along

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Deshpande, Mangirish, Pearl Dighe, and Sujit Nagare. "A Review of Antiulcer Activity of Some Medicinal Plants." Journal of Drug Delivery and Therapeutics 14, no. 8 (2024): 201–13. http://dx.doi.org/10.22270/jddt.v14i8.6722.

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Peptic ulcer is a gastrointestinal disorder and with increased prevalence. Peptic ulcer is breaking of endothelial lining of stomach and exposing underlying tissues. Peptic ulcer occurs due to high secretion of acid and reduced defensive factors in stomach and duodenum. It is imbalance between aggressive and defensive factors. Non-steroidal anti-inflammatory drugs and Helicobacter pylori infection also increases the risk of peptic ulcer. Indiscriminate use of synthetic drugs leads to adverse effects and concomitant use of antibiotics potentiates drug-drug interaction thus search of drugs from

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Azyenela, Lola, Ringga Novelni, and Viora Lusiana Satri. "A Study of Potential Drug-Drug Interactions in Peptic Ulcer Patients in Dr. M. Djamil Hospital Padang in 2019." Journal of Pharmaceutical Sciences and Community 20, no. 2 (2023): 144–50. http://dx.doi.org/10.24071/jpsc.003909.

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A peptic ulcer is a gastrointestinal tract disorder caused by excessive secretion of acid and pepsin by the gastric mucosa. The combined use of drugs in peptic ulcer management may potentially cause drug-to-drug interactions. Drug interactions are caused when two or more drugs interact and may affect the effectiveness of the other drugs. This study aims to analyze the potential drug reactions in peptic ulcer patients in the internal medicine ward of Dr. M. Djamil General Hospital Padang in 2019. This study was a descriptive, non-experimental study with retrospective data, while data analysis u

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Vandana1*, Pooja Solanki2 Ankit Dahiya3 Rajashekar Kamalla4 and Varun Kumar Sarkar5. "" Zollinger-Ellison syndrome in dogs "." Trends In Agriculture Science 2, no. 7 (2023): 541–45. https://doi.org/10.5281/zenodo.8184375.

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<strong>Zollinger-Ellison syndrome </strong>is a rare disorder caused by a tumor called a gastrinoma. The tumor secretes the hormone gastrin, which causes excess production of gastric acid, leading to severe recurrent ulcers of the esophagus, stomach, duodenum, and jejunum. The syndrome is characterized by severe peptic ulcer disease caused by gastrin-secreting neuroendocrine tumors, most commonly located in the <strong>duodenum and pancreas</strong>. Frequently gastrinomas are not recognized at initial clinical presentation and are often mistreated. Symptoms that should raise suspicion of a g

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Awuchi, Chinaza Godswill, Purabi Saha, Vandana Sonaji Amle, et al. "A Study of Various Medicinal Plants used in Ulcer Treatment: A Review." Journal for Research in Applied Sciences and Biotechnology 2, no. 1 (2023): 234–46. http://dx.doi.org/10.55544/jrasb.2.1.34.

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Many people suffer from ulcer, a disorder of the digestive tract. Simply put, it's an inflamed break in the skin or the mucus membrane lining the digestive tract. Whenever there is a change in the equilibrium, such as increased aggression or decreased mucosal resistance, ulceration develops. Reasons for this could include drug use, poor diet, stress, and other similar factors. Peptic ulcers are a general term for any type of stomach or duodenal ulcer. To develop, peptic ulcers need mucosal defences to be compromised in addition to gastric juice acid and peptic activity. Ulcers can be treated w

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Sujal, Sujal, Aanchal Chandel, Dr Neeraj Bhandari, and Amisha Gautam. "A Review Article on Peptic Ulcer." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 995–1006. https://doi.org/10.35629/4494-09069951006.

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Peptic ulcer disease (PUD) refers to the development of open sores or lesions on the lining of the stomach, duodenum, or esophagus, caused by an imbalance between aggressive factors (like gastric acid) and protective factors. The two most common types of peptic ulcers are gastric ulcers, which form in the stomach, and duodenal ulcers, which occur in the first part of the small intestine. The primary etiological factors for PUD include infection with Helicobacter pylori, long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), and excessive alcohol consumption, though stress and smoking

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Obeagu, Emmanuel Ifeanyi, and Getrude Uzoma Obeagu. "Exploring the intricate relationship between peptic ulcers and immunohematological responses: A narrative review." Medicine 104, no. 15 (2025): e42187. https://doi.org/10.1097/md.0000000000042187.

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Peptic ulcers have long been a focus of medical research due to their significant impact on public health worldwide. Traditionally attributed to factors such as Helicobacter pylori infection and excessive gastric acid secretion, recent scientific endeavors have increasingly unveiled the pivotal role of immunohematological responses in the pathogenesis and clinical course of peptic ulcers. This review aims to synthesize and analyze the intricate relationship between peptic ulcers and immunohematological responses, shedding light on the complex interplay between the immune system and ulcer devel

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Vimala, G., and F. Gricilda Shoba. "A Review on Antiulcer Activity of Few Indian Medicinal Plants." International Journal of Microbiology 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/519590.

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Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. It may be due to the regular usage of drugs, irregular food habits, stress, and so forth. Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gast

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Sarma, Usha, and Upasana Kalita. "Histopathological Study of Gastroduodenal Biopsies and to See the Prevalence of Helicobacter Pylori with the Help of Special Stains in Selected Cases in North East India- A Cross Sectional Study in a Tertiary Care Centre." Asian Pacific Journal of Cancer Biology 9, no. 4 (2024): 515–20. https://doi.org/10.31557/apjcb.2024.9.4.515-520.

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Background: Acid peptic disease (APD), including gastric ulcers, duodenal ulcers, and gastro esophageal reflux disease is a common disorder of the gastrointestinal region, the pathogenesis of which involves an imbalance between acid secretion and gastric mucosal defenses. Acid peptic diseases mostly affect the esophagus, stomach, and duodenum. The imbalance could be caused by factors such as H pylori infection and acid secretory abnormalities in APD. Helicobacter pylori infection is a factor in 85% to 100% of duodenal ulcers and 70% to 90% of gastric ulcers. Besides, malignancies are also fair

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Aggarwal, Punam, R. Galib, PK Prajapati, and PramodR Yadav. "Indukanta ghritam – An ayurvedic formulation for acid peptic disorder and longevity: A review." Journal of Ayurveda 15, no. 3 (2021): 215. http://dx.doi.org/10.4103/joa.joa_149_20.

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Israilova, A. T., E. M. Mamytova, Yu Kh-M. Shidakov, K. D. Musabaeva, R. R. Tukhvatshin, and Aizhanat Nurbek kyzy. "THE EFFECT OF DIET ON THE BIOCHEMICAL, ACID-BASE AND GAS HOMEOSTASIS OF BLOOD." Vestnik of the Kyrgyz-Russian Slavic University 25, no. 5 (2025): 112–16. https://doi.org/10.36979/1694-500x-2025-25-5-112-116.

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The aim of the present study was to establish the mechanism of diet (nutrition regime) effect on biochemical, acid-base and gas homeostasis of blood under experimental conditions. Diet, being an important component of the exposome - a set of factors of external and internal environment, as well as lifestyle – has a prolonged effect on the human body throughout life. Depending on its qualitative and quantitative composition, the diet can act as a therapeutic and prophylactic tool, contributing to the maintenance of homeostasis, and as a risk factor for the development of severe chronic patholog

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Kumari, Risha, and Shweta Agarwal. "Role of Proton Pump Inhibitors in the Management of Peptic Ulcer." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 6 (2023): 7070–80. http://dx.doi.org/10.37285/ijpsn.2023.16.6.7.

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Proton pump inhibitors (PPIs) have been used to treat a variety of conditions affecting the upper gastrointestinal tract including gastroesophageal reflux disease (GERD), esophagitis, Zollinger-Ellison syndrome (ZES) and dyspepsia. PPIs are also useful in the treatment of Helicobacter pylori infection as well as the prevention of upper gastrointestinal tract ulcers and bleeding in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs). It is critical to get the best clinical response possible for people with an upper gastrointestinal peptic disorder. This is dependent on the PP

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K. Raut, Dr Shivani, and Dr Archana S. Dachewar. "“AYURVEDIC APPROACH OF AMLAPITTA W.S.R. TO ACID PEPTIC DISEASE : A REVIEW”." Sanjeevani Darshan - National Journal of Ayurveda & Yoga 02, no. 04 (2024): 01–17. https://doi.org/10.55552/sdnjay.2024.2401.

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Amlapitta, a condition associated with the Annahava Srotas in Ayurveda, has become increasingly common in modern times due to unhealthy dietary habits and lifestyle choices. The term "Amlapitta" is derived from two components: "Amla" and "Pitta." Ayurvedic texts describe Amlapitta as a disorder characterised by an increase in both the quantity and sourness of vitiated Pitta. Acharya Chakrapani defines it as “Pitta endowed with the quality of sourness." In contemporary medical terminology, this condition can be compared to gastritis or acid peptic disease. In Ayurveda, Amlapitta is managed by b

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Sitharthan, R. "Homoeopathy in Treatment of Gastro Intestinal Disorders - A Retrospective Study." Advancements in Homeopathic Research 8, no. 1 (2023): 41–46. http://dx.doi.org/10.48165/ahr.2023.8.1.4.

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Introduction: Acid peptic disorder (APD) is a condition which includes peptic ulcer and gastro esophageal reflux disease (GERD). The highest prevalence rate of gastric disorders had been found out between ages 45-50. Dyspepsia is a term used for reduced digestion or indigestion. GERD is referred to as condition where there is regurgitation of stomach contents to the esophagus. Around 58.7% of peoples are having acid regurgitation or heart burn yearly once and 19.8% weekly once. Worldwide functional gastrointestinal disorder are commonest now a days, Irritable Bowel Syndrome (IBS) is also one a

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Pillai, Arshia S., Paul T. Francis, Niveditha Kartha, and Minu Maria Mathew. "An assessment of functional limitations and its relation to morbidity pattern among the elderly residing in urban area, Kerala, India." International Journal Of Community Medicine And Public Health 9, no. 1 (2021): 116. http://dx.doi.org/10.18203/2394-6040.ijcmph20214809.

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Background: Ageing is an inevitable process and a person aged 60 years or above is often referred to as ‘elderly’. Older age is characterized by emergence of several complex health states that tend to occur only later in life and that do not fall into discrete disease categories. These are commonly called as geriatric syndromes. The aim of the study was to estimate the prevalence of functional limitations among the elderly and to determine the association between functional limitations and morbidity pattern among the elderly residing in urban area in Ernakulam district, Kerala.Methods: A commu

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Tripathi, Ankita, Shubham Srivastava, Minakshi Gupta, Shristi Raj, and Farheen Shareef. "VALIDATION OF SCREENING MODELS OF PEPTIC ULCER: A REVIEW." International Research Journal of Pharmacy 12, no. 12 (2022): 16–26. http://dx.doi.org/10.7897/2230-8407.1212174.

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The stomach plays an important role in the digestion of the things we consume. This part of the body can withstand a wide range of harmful substances, such as hydrochloric acid, alcohol, refluxed bile salts, and other irritants. Upper abdominal pain may be a symptom of a gastrointestinal disorder known as Peptic Ulcer if you eat an unhealthy diet, smoke, drink too much alcohol, or take NSAIDs on a regular basis. You may also have a sedentary lifestyle. Today, gastric hyperacidity and gastroduodenal ulcers are very common problems all over the world. In this article, the author tries to give an

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Akhilesh, Kumar Verma. "A Comprehensive Overview of Amlapitta : Traditional Insights and Modern Perspectives." INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH AND CREATIVE TECHNOLOGY 9, no. 2 (2023): 1–3. https://doi.org/10.5281/zenodo.10733740.

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Amlapitta, known as acid peptic disorder or hyperacidity in contemporary medical terms, is a significant health concern that affects a considerable portion of the global population. Ayurveda, the ancient Indian system of medicine, offers a holistic approach to the management and treatment of Amlapitta through Kayachikitsa (general medicine). This article aims to explore the concept of Amlapitta in Ayurveda, its pathophysiology, diagnostic criteria, and a detailed discussion on Kayachikitsa, incorporating both traditional insights and modern perspectives. The synthesis of ancient wisdom with co

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Dhivakaran, A., M. Gomathi, S. Shamini, and G. Priyanga. "Anti-Ulcer Tablet of Pantoprazole: A Brief Review Of Its Pharmacological Properties and Therapeutic Uses with Respect To Effervescent Tablets." American Journal of PharmTech Research 13, no. 02 (2023): 19–34. https://doi.org/10.5281/zenodo.7878369.

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ABSTRACT Peptic ulcer is a common gastrointestinal disease seen among many peoples. It may be caused by irregular food habits, spicy foods, either an infection or long-time use of medications, drugs and stress. An ulcer depends upon the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defences. A number of anti-ulcer drug are available for curing ulcer disease. Standard treatment is including antibiotics and proton pump inhibitors. But the same time these drugs are expensive and there are many side effects caused by these drugs comparing to other herbal medicin

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Dhivakaran, A., M. Gomathi, S. Shamini, and G. Priyanga. "Anti-Ulcer Tablet of Pantoprazole: A Brief Review Of Its Pharmacological Properties and Therapeutic Uses with Respect To Effervescent Tablets." American Journal of PharmTech Research 13, no. 02 (2023): 19–34. https://doi.org/10.5281/zenodo.8046873.

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ABSTRACT Peptic ulcer is a common gastrointestinal disease seen among many peoples. It may be caused by irregular food habits, spicy foods, either an infection or long-time use of medications, drugs and stress. An ulcer depends upon the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defences. A number of anti-ulcer drug are available for curing ulcer disease. Standard treatment is including antibiotics and proton pump inhibitors. But the same time these drugs are expensive and there are many side effects caused by these drugs comparing to other herbal medicin

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Gurung, Sukh Bahadur, Shiva Raj KC, Purnima Gyawali, and Gyanendra Lal Amatya. "Comparative Study on Effect of Rabeprazole Versus Omeprazole in Acid-peptic Disorder with Helicobacter pylori Infection." Journal of Nepal Health Research Council 17, no. 4 (2020): 479–84. http://dx.doi.org/10.33314/jnhrc.v17i4.1961.

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Background: Gastritis is one of the common diseases, which is frequently caused by Helicobacter pylori. Triple therapy has resulted significant decrease in morbidity and complications. Newer proton pump inhibitor drug rabeprazole has been introduced in the market. The aim of this study is to compare its efficacy with omeprazole in triple therapy regimen.Methods: A total of 100 patients who were positive for Helicobacter pylori and gave consent in participating in the study were included. Fifty patients were prescribed omeprazole-based triple therapy and other 50 were prescribed with rabeprazol

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Kumar, Amit, Md Afsar Alam, Jitendra Kumar, and A. K. Tiwary. "An observational study on benign/malignant gastric outlet obstruction in tertiary care centre of RIMS, Ranchi, India." International Surgery Journal 5, no. 1 (2017): 54. http://dx.doi.org/10.18203/2349-2902.isj20175504.

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Background: Gastric outlet obstruction is a group of clinico-patho physiological consequence of mechanical impediment of gastric emptying. Clinical entities that can result in gastric outlet obstruction are categorized into two well-defined groups of causes - benign and malignant. The proximal stomach is now the most common site for gastric carcinoma in the west but in Japan and developing countries like India the distal gastric cancer (antrum 13% and pylorus 7%) still predominates. Diagnosis of gastric outlet obstruction depends on different clinical features and certain investigations. The d

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Safdar, Nida Ali, Soha Jabeen, and Essra Ali Safdar. "Zollinger-Ellison Syndrome: Causes, Symptoms, and Modern Approaches to Treatment." Acta Pharma Reports 3, no. 1 (2024): 17–19. http://dx.doi.org/10.51470/apr.2024.03.01.17.

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Zollinger-Ellison syndrome (ZES) is a rare disorder characterized by the development of one or more tumors, known as gastrinomas, in the pancreas or upper part of the small intestine. These gastrinomas secrete excessive amounts of the hormone gastrin, leading to an overproduction of stomach acid, which subsequently causes recurrent peptic ulcers, abdominal pain, and diarrhea. ZES can affect individuals at any stage of life, though it is most commonly diagnosed between the ages of 20 and 60. This article provides an in-depth overview of the causes, symptoms, and diagnostic methods for Zollinger

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Arsita, Elli, and Achmad Fauzi. "Role of Proton Pump Inhibitor in the Management of Acid-Related Disorders." Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 15, no. 1 (2014): 31–7. http://dx.doi.org/10.24871/151201431-7.

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Proton pump inhibitor (PPI) is the strongest inhibitor to gastric acid secretion. PPI is effective in all gastricacid disorders, such as: peptic ulcer, gastroesofageal reflux disease, non steroid anti inflammatory drugs (NSAIDs)gastropathy, and Zollinger-Ellison syndrome. Several studies comparing one PPI to another. Although somedifferences have been reported, there are small differences with unclear clinical importance.PPI has side effects that may be related to diarrhea due to Clostridium difficile, pneumonia, hip fracture, vitamin B12 deficiency, and IgE mediated allergic reaction. Several

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Priyanka G. Ghonge, Pooja R. Hatwar, Prashant G. Shelke, Ravindra L. Bakal, and Sanika S. Khandare. "A comprehensive review on Peptic Ulcer Disease: Types, pathophysiology, diagnosis and treatment." GSC Advanced Research and Reviews 23, no. 3 (2025): 026–35. https://doi.org/10.30574/gscarr.2025.23.3.0156.

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Peptic ulcer disease (PUD) is a prevalent gastrointestinal disorder characterized by ulcers in the stomach or duodenum. The primary causes of PUD are Helicobacter pylori infection and non-steroidal anti-inflammatory drug (NSAID) use. If left untreated, PUD can lead to complications such as bleeding, perforation, and obstruction. The symptoms of PUD include heartburn, regurgitation, nausea, vomiting, and abdominal pain. Diagnosis is typically based on symptoms and radiology. Treatment includes medications to reduce acid production, eradicate H. pylori, and protect the mucosa. In severe cases, s

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B N, Chaithra, Ullas Prakash D’Souza, Prasanna Shama Khandige, and Vandana Sadananda. "Antiulcer activity of ethanolic extract of Arctocarpus hirsutus Lam. leaves in albino Wistar rats." Journal of Applied Pharmaceutical Research 11, no. 5 (2023): 44–51. http://dx.doi.org/10.18231/j.joapr.2023.11.5.44.51.

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Peptic ulcers, a prevalent gastrointestinal disorder, remain a significant health concern. Artocarpus hirsutus Lam., a plant deeply rooted in traditional medicine, has been historically employed to address various health issues. Each component of this plant showcases diverse therapeutic activities, offering a holistic approach to health concerns. This study aimed to explore the gastroprotective and antiulcerogenic potential of the ethanol-based extract derived from Artocarpus hirsutus Lam leaves. Administered orally in 100, 200, and 400mg/kg doses, the extract's effects were compared with esta

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Gupta, Priti, Solveig A. Cunningham, Mohammed K. Ali, Sailesh Mohan, Pranab Mahapatra, and Sanghamitra C. Pati. "Multimorbidity clusters and associated health care cost among patients attending psychiatric clinics in Odisha, India." Indian Journal of Psychiatry 65, no. 7 (2023): 736–41. http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_463_22.

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Introduction: There is a dearth of data on common multimorbidity clusters and the healthcare costs for individuals with mental health disorders. This study aimed to identify clinically meaningful physical-mental multimorbidity clusters, frequently occurring clusters of conditions, and healthcare utilization patterns and expenditure among patients attending a psychiatric outpatient clinic. Materials and Methods: Data were collected in the psychiatric outpatient department among patients aged 18 years and above in February-July 2019 (n = 500); follow-up data on non-communicable disease incidence

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Krilis, S. A., J. L. Macpherson, D. J. de Carle, G. E. Daggard, N. A. Talley, and C. N. Chesterman. "Small bowel mucosa from celiac patients generates 15-hydroxyeicosatetraenoic acid (15-HETE) after in vitro challenge with gluten." Journal of Immunology 137, no. 12 (1986): 3768–71. http://dx.doi.org/10.4049/jimmunol.137.12.3768.

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Abstract Celiac disease (gluten-sensitive enteropathy [GSE]) is a disorder characterized by small intestinal mucosal injury caused by dietary exposure to wheat gluten and similar proteins. There is evidence that the mucosal injury is immunologically mediated and there is an inflammatory infiltrate present in the mucosa. It is postulated that release of lipid-derived inflammatory mediators may be involved in the pathogenesis of the mucosal injury. Jejunal mucosal biopsy samples from patients with GSE and from a group of patients who were subsequently shown to have normal jejunal mucosa were inc

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Li, Min, Wenchao Dan, Hui Zhang, Yong’en Yun, and Qingyong He. "Xiao Chai Hu Tang for Peptic Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Evidence-Based Complementary and Alternative Medicine 2021 (April 29, 2021): 1–13. http://dx.doi.org/10.1155/2021/6693677.

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A peptic ulcer (PU) is a digestive disorder most commonly found in clinical practice. An oriental herbal formula, Xiao Chai Hu Tang (XCHT), has been used to treat PU for an extended period in China. The effectiveness and safety of XCHT in treating peptic ulcers was evaluated using a systematic review of randomized controlled trials (RCTs). Studies were systematically retrieved from CNKI, Embase, Medline, PubMed, SinoMed, VIP, Wanfang, and Web of Science. The following information was extracted from the relevant RCTs: the clinical efficacy rate, recurrence rate, clinical efficacy of traditional

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Solecki, Michał, Grzegorz Wallner, Wioletta Masiak, and Grzegorz Ćwik. "What’s new about symptomatic reflux disease." Polish Journal of Public Health 125, no. 1 (2015): 17–19. http://dx.doi.org/10.1515/pjph-2015-0015.

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Abstract During the last 4 decades reflux disease (GERD) has evolved from being a rare clinical problem to a disease with high incidence. This automatically rises its social costs. First descriptions came from western countries only but nowadays there are many published papers from Asia and Middle East that can be found on the Internet. There is no clear explanation for this fact. Our understanding of GERD has changed over the time. At first GERD, hiatal hernia and oesophagitis were synonyms. Since the 1940s when the first manometrical studies were done it was concerned as lower oesophageal sp

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Krithika, J., and Kailas Mogal. "Clinical Profile and Esophagogastroduodenoscopy Finding in Patients with Acid Peptic Disease at a Tertiary Health Care Centre." MVP Journal of Medical Sciences 4, no. 1 (2017): 1. http://dx.doi.org/10.18311/mvpjms/0/v0/i0/703.

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Background and Aims: Acid Peptic Diseases (APD) is a common disorder. Population based survey revealed that 44% of the population reported monthly heartburn and 19.8% suffered from heartburn or acid regurgitation at least once a week. An approximate prevalence of 10–20 % was identified for GERD, in the Western world while in Asia this was lower, at less than 5% In this study, we are going to study the clinical features and esophagogastroduodenoscopy (EGD) findings in patients presenting in our centre in order to come to a precise diagnosis and indentify various risk factors contributing to it.

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Shrushti Nimje, Vidula Gujjarwar, and Akanksha Sharma. "A systematic review on causes and triggers contributing to Amlapitta in contemporary era." Journal of Ayurveda and Integrated Medical Sciences 9, no. 6 (2024): 131–37. http://dx.doi.org/10.21760/jaims.9.6.19.

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In Ayurveda Ahara is considered as the best preventive medicine and solely responsible for health and illness, sorrow and happiness. Unlike many infectious diseases, lifestyle disorders are mostly preventable through modifications in lifestyle behaviors. Amlapitta, is often considered a lifestyle disorder were lifestyle choices play a significant role in its development and exacerbation. Amlapitta is the commonest Vyadhi of Annavaha Strotas, caused by vitiated Agni where Amlaguna of Pachak Pitta increases due to Samata manifesting symptoms such as Avipaka (indigestion), Amlotkalesh or Tikta Am

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Sourabh, Das, Debnath Maharshi, Choudhury Arkadip, Majumder Nabaneet, Nath Sanjay, and Chakraborty Avik. "Clinicopathological Study of Helicobacter Pylori Infection in Patients with Acid Peptic Disorder Attending Tripura Medical College and Dr B.R.A.M Teaching Hospital." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1175–83. https://doi.org/10.5281/zenodo.11200144.

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<strong>Introduction:</strong> Acid peptic disorder (APD) is a global issue caused by imbalances in gastric secretions, leading to conditions like gastritis, ulcers, and duodenal ulcers. H. pylori, a Gram-negative bacterium, are a common human pathogen, colonizing 60% of the world’s population. It causes chronic inflammation in human gastric mucosa, leading to progressive damage to the stomach lining and various stomach diseases without treatment. This study aims to determine the prevalence of H. pylori infection in adult patients with APD symptoms, compare the sensitivity and speci

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Sruthi, Y.* Dr. Vishnu Kangralkar. "A Comprehensive Review of Experimental Models, Evaluation Parameters, And Natural-Synthetic Therapeutics for Peptic Ulcer Treatment." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 929–46. https://doi.org/10.5281/zenodo.15350568.

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Peptic ulcer disease (PUD) is a gastrointestinal disorder resulting from an imbalance between aggressive factors such as gastric acid and pepsin, and the protective mechanisms of the gastrointestinal mucosa. Common causes include Helicobacter pylori infection, excessive use of non-steroidal anti-inflammatory drugs (NSAIDs), alcohol intake, smoking, and dietary imbalances. Conventional therapeutic approaches, including proton pump inhibitors (PPIs) and histamine-2 receptor antagonists, have proven effective but are often associated with adverse effects, drug interactions, and high recurrence ra

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Aphale, Parth, Dharmendra Sharma, and Himanshu Shekhar. "Homeopathy as an Emerging Alternative for GERD Management: A Comprehensive Review." International Journal of High Dilution Research - ISSN 1982-6206 23, cf (2023): 128–45. http://dx.doi.org/10.51910/ijhdr.v23icf.1414.

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Background: Gastroesophageal reflux disease (GERD) is a common condition characterized by stomach contents flowing into the esophagus, causing distressing symptoms and potential complications. GERD is primarily linked to lower esophageal sphincter dysfunction, and its symptoms can impact quality of life. Treatment options include lifestyle changes, medications, and surgery, with concerns about prolonged medication use. Homeopathy is an alternative approach gaining recognition and interest as an alternative to conventional orally administered drugs for GERD. Aim/Objective: This review examines

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Timilsina, Sameer, Bimal Sharma Acharya, and Barun Shrestha. "PREVALENCE OF HELICOBACTER PYLORI INFECTION IN ENDOSCOPIC BIOPSY SPECIMEN AMONG ACID PEPTIC DISORDER PATIENTS ATTENDING GASTRO-OUTPATIENT DEPARTMENT OF A TERTIARY CARE CENTER IN CENTRAL NEPAL." Journal of Chitwan Medical College 13, no. 2 (2023): 86–88. http://dx.doi.org/10.54530/jcmc.1254.

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Background: Acid peptic disorder (APD) is the most frequently encountered provisional diagnosis in general practice with Helicobacter pylori being the major causal agent. In the present study we aim to report the incidence of H. pylori infection among patients undergoing upper gastrointestinal endoscopy at a tertiary care center in central Nepal. Methods: A hospital-based cross-sectional study was conducted among 101 patients with diagnosis of APD. An Upper gastrointestinal (UGI) Endoscopy was performed on all the participants and biopsy specimen was obtained from various parts depending on th

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Martins, José Luis Rodrigues, Dayane Moreira da Silva, Iziara Ferreira Florentino, et al. "Gastroprotective Effect of oenothein B: a Romising Macrocyclic Ellagitannin." Fronteira: Journal of Social, Technological and Environmental Science 13, no. 2 (2024): 152–65. http://dx.doi.org/10.21664/2238-8869.2024v13i2.p152-165.

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A peptic ulcer disease is a significant gastrointestinal disorder with a high prevalence of 80% in developing countries and 40% in developed countries. Oenothein B, a macrocyclic ellagitannin, has emerged as a potential therapeutic agent for this condition. The aim of this study was to investigate the anti-ulcer activity of Oenothein B and elucidate the underlying mechanisms involved in its gastroprotective effects. The anti-ulcer activity of Oenothein B was assessed using various experimental models, including ulcers induced by indomethacin, HCl/ethanol, and pyloric ligation. Several paramete

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Mukherjee, Deepannita Roy, Sayak Tanbir, Sohel Mondal, et al. "Exploring the Gut Microbiome's Influence on Peptic Ulcer Disease: Mechanistic Insights, Pharmacological Implications, and Emerging Therapeutic Strategies." Journal of Drug Delivery and Therapeutics 15, no. 4 (2025): 209–18. https://doi.org/10.22270/jddt.v15i4.7088.

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Background: The gastrointestinal disorder Peptic Ulcer Disease (PUD) leads to mucosal damage in either stomach or duodenal tissue because of acid-peptic injury. The available evidence demonstrates that Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) usage serve as proven ulcer causes but new research shows the gut microbiome as contributing to ulcer development and therapeutic approaches. Objective: The purpose of this section is to examine the standard H. pylori ulcer development process while examining host immune responses through gut microbial alte

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Pokhrel, Nayanum, Basudha Khanal, Keshav Rai, Manish Subedi, and Narayan Raj Bhattarai. "Application of PCR and Microscopy to Detect Helicobacter pylori in Gastric Biopsy Specimen among Acid Peptic Disorders at Tertiary Care Centre in Eastern Nepal." Canadian Journal of Infectious Diseases and Medical Microbiology 2019 (February 5, 2019): 1–6. http://dx.doi.org/10.1155/2019/3695307.

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Background. Helicobacter pylori infection is most prevalent in developing countries. It is an etiological agent of peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoid tissue (MALT) lymphoma. Despite the development of different assays to confirm H. pylori infection, the diagnosis of infection is challenged by precision of the applied assay. Hence, the aim of this study was to understand the diagnostic accuracy of PCR and microscopy to detect the H. pylori in the gastric antrum biopsy specimen from gastric disorder patients. Methods. A total of 52 patients with gastric disorde

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Sarma, Usha, and Upasana Kalita. "Histopathological Spectrum of Gastroduodenal Biopsies in North East India - A 1 Year Cross-sectional Study in a Tertiary Care Centre." Asian Pacific Journal of Cancer Biology 9, no. 4 (2024): 509–14. https://doi.org/10.31557/apjcb.2024.9.4.509-514.

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Background: Gastrointestinal problems are very common nowadays and most people are likely to experience gastrointestinal symptoms throughout their lives. Acid peptic disease (APD), including gastric ulcers, duodenal ulcers, and gastro esophageal reflux disease is a common disorder of the gastrointestinal region, the pathogenesis of which involves an imbalance between acid secretion and gastric mucosal defenses. Besides, malignancies are also fairly common in these regions. This is a study done in 100 cases of gastroduodenal biopsies in a 1 year period. Aims and Objectives: To see the histopath

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Pantha, S., and P. Gartoulla. "Disease pattern in women of mountain Area â€œ A study of women attending gynaecological health camp at district hospital, Jumlaâ€." Journal of General Practice and Emergency Medicine of Nepal 1, no. 1 (2010): 50–54. http://dx.doi.org/10.59284/jgpeman198.

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Introduction: The study aims in finding out the basic reproductive health condition of the women in rural areas of Nepal who are lacking far behind in access to basic health facilities and to fill in the gap of the evidence present in these areas.Methods: This study is the descriptive analysis of women who attended the 10 day long gynaecological Health camp organized at the premises of District Hospital, Jumla during October 2008, led by a Gynaecologist from Kathmandu.The diagnosis was made on clinical evaluation. A carbon copy of the prescription was made at the time of examination and was la

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Poonia, Ritesh, and Arun Gupta. "A COMPARATIVE STUDY TO EVALUATE THE EFFECT OF VIRECHANA KARMA WITH TRIVRITADI KWATH AND SHAMAN CHIKITSA WITH AVIPATIKARA CHURNA IN THE MANAGEMENT OF URODAHA (RETROSTERNAL BURNING) IN AMLAPITTA (ACID PEPTIC DISORDER)." International Journal of Research in Ayurveda and Pharmacy 11, no. 6 (2020): 157–67. http://dx.doi.org/10.7897/2277-4343.1106203.

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In the recent years there has been an unprecedented increase in the incidence of Gastrointestinal System disorders due to change in lifestyle, diet pattern, behavioral pattern, mental stress and also hazardous use of painkillers. Ayurveda comes with varieties of treatment options to cure the GI disorders without causing any harmful effect. The aim of this study is to compare between Shodhan and Shaman therapy in Amlapitta, to evaluate the efficacy of Virechana Karma and Shaman Chikitsa. The criterions of diagnosis of patients was based on sign and symptoms of Amlapitta and Ayurvedic and modern

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Al-Gabri, Naif, Gehad M. Elnagar, Sultan A. M. Saghir, et al. "Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats." BioMed Research International 2022 (January 24, 2022): 1–10. http://dx.doi.org/10.1155/2022/9246785.

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Objective. The present study was aimed at investigating the possible antiulcer activities of some natural phytochemicals Aloe perryi leaf extract (APLE) and flower extract (APFE) in addition to the date palm seed extract (DPSE) and the oily samples of DPSE in a pylorus ligation-induced ulcer model using ranitidine as a standard antiulcer drug. Background. Peptic ulcer is a prevalent gastrointestinal disorder due to hypersecretion of gastric acid. It affects four million people worldwide, and 2-10% of these ulcers are perforated and cause bleeding. This increases the risk of morbidity and morta

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Kale-Pradhan, Pramodini B., Heather K. Landry, and William T. Sypula. "Esomeprazole for Acid Peptic Disorders." Annals of Pharmacotherapy 36, no. 4 (2002): 655–63. http://dx.doi.org/10.1345/aph.1a104.

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OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical efficacy, and safety of esomeprazole, a new proton-pump inhibitor (PPI). DATA SOURCES: A MEDLINE search (1966–March 2001) was conducted for relevant literature using the terms esomeprazole, Nexium, and H199/18. Abstracts from the XXXII Nordic Meeting of Gastroenterology and journal articles provided by AstraZeneca were reviewed. STUDY SELECTION AND DATA EXTRACTION: All available studies on the pharmacology, pharmacokinetics, clinical efficacy, and safety of esomeprazole were reviewed. DATA SYNTHESIS: Esomeprazole is a new PPI an

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Alzahrani, Mohammed A., Faisal S. Alamri, Hatem M. Alshahrani, et al. "Factors influencing the quality of life of GERD patients in the Aseer Region, Saudi Arabia." Journal of Family Medicine and Primary Care 12, no. 12 (2023): 3217–21. http://dx.doi.org/10.4103/jfmpc.jfmpc_620_23.

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Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disorder characterized by troublesome symptoms, including heartburn and acid regurgitation. GERD is associated with complications such as peptic stricture, Barrett's esophagus, and esophageal adenocarcinoma, and it negatively affects quality of life (QoL). Aims: To assess the factors influencing the QoL of GERD patients in the Aseer region of Saudi Arabia. Settings and Design: This descriptive cross-sectional study used self-administered questionnaires in a study population of patients aged ≥18 years from Aseer, Saudi Ar

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Singh, T., S. Nagesh, T. K. Ray, and S. Sharma. "Geriatric Women: An Unheard Voice." Journal of Comprehensive Health 5, no. 1 (2020): 76–86. http://dx.doi.org/10.53553/jch.v05i01.007.

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Background: Geriatric age group constitutes 8.3% of Indiaâ€™s population, with sex ratio in favour of elderly women by 1022:1000. Health problems of women in geriatric age in particular have not been explored reasonably and therefore little attention from health planners was made available for geriatric women across the developing countries including India. Objectives: 1.To assess the magnitude and pattern of health problems in geriatric women, 2. To find out relation between socio-demographic factors and health problems of subjects. Methods: A community-based cross-sectional study was conduct

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