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1

National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. London: National Institute for Clinical Excellence, 2003.

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2

National Institute for Clinical Excellence. Guidance on the use of imatinib for chronic myeloid leukaemia. London: National Institute for Clinical Excellence, 2002.

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3

Rooney, Maria Anne. An evaluation of the immune competence of children with common Acute Lymphoblastic Leukaemia, both during and post-treatment, by an investigation of the Lymphocyte sub-populations using monoclonal antibodies and the Alkaline Phosphatase Anti-Alkaline Phosphatase technique. [s.1: The Author], 1989.

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4

Mendez, Irvin. Acute Myeloid Leukaemia: Symptoms, Diagnosis and Treatment. Nova Science Publishers, Incorporated, 2018.

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5

M, Carella Angelo, ed. Chronic myeloid leukaemia: Biology and treatment. London: Martin Dunitz, 2001.

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6

Goldman, John M., Angelo M. Carella, George Q. Daley, Connie J. Eaves, and Hehlmann Rudiger. Chronic Myeloid Leukaemia: Biology and Treatment. Taylor & Francis Group, 2003.

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7

McCann, Shaun R. Leukaemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0007.

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The word leukaemia still is associated with foreboding and a fear of premature death. Steady advances have been made in the treatment of childhood leukaemia but, with notable exceptions, the same is not true in adults. The so-called genetic/molecular revolution has extended the understanding of the pathogenesis of many forms of leukaemia but, as yet, has rarely facilitated cure. With the introduction of tyrosine kinase inhibitor therapy, chronic myeloid leukaemia is the obvious exception but it still needs to be seen as to whether the cytogenetic/molecular revolution can provide cures for many
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8

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, and Gareth Morris-Stiff. Bone and soft tissue malignancies. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199689842.003.0025.

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Haematological malignancies examines the epidemiology, genetics, clinical presentation and classification of these diseases, and presents current treatment approaches for each. First are the acute leukaemias, and the management of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). Chronic myeloid leukaemia, its genetics and sensitivity to tyrosine kinase inhibitors, is described. Myelodysplastic syndromes and their management, are followed by chronic lymphoid leukaemias, a large heterogeneous group of diseases, and their treatment. Hodgkin lymphoma, its pathology and presen
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9

Cutter, David, and Martin Scott-Brown. Treatment of cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0325.

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The variety of conditions that are considered to be ‘cancer’ is extremely wide, with marked variation in the management approach from disease to disease. A common feature in the management of malignant conditions, however, is the involvement of a wide range of medical professionals at different stages of the patient pathway. This commonly includes physicians, surgeons, radiologists, pathologists, medical oncologists, radiation oncologists, and specialist nurses, as well as a plethora of other allied disciplines. As such, a practice that has been widely adopted is to work as a multidisciplinary
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10

McCann, Shaun R. Molecules, genes, and gene therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0009.

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The twenty-first century has brought many innovations in haematology, with improved diagnostic technology, which may inform treatment choices for malignant diseases, and a better understanding of the genetics and/or epigenetics underlying many diseases. Unfortunately, the aetiology of most of these diseases still eludes us, and some common diseases such as sickle cell disease await simple, inexpensive, and widely available curative treatment. For reasons that are often obscure, some diseases have become fashionable and attract large research financial backing, whereas some do not. With the adv
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11

Acute Leukaemias (Haematology & Blood Transfusion). Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1994.

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12

(Editor), Gunther Schellong, Wolfgang Hiddemann (Editor), and Jorg Ritter (Editor), eds. Acute Leukaemias (Haematology and blood transfusion). Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1990.

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13

McCann, Shaun R. Combination chemotherapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0012.

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One of the major advances in haematology during the past six decades has been the development of combination chemotherapy. However, some would dispute the claim that combination chemotherapy has been a major therapeutic advance, arguing that survival for most common cancers has not improved since the advent of chemotherapy. It is certainly true that the survival of children with acute lymphoblastic leukaemia has improved and that the drug imatinib mesylate and its derivatives have changed the outcome for most patients with chronic myeloid leukaemia. Likewise, combination chemotherapy has great
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14

Provan, Drew, Trevor Baglin, Inderjeet Dokal, and Johannes de Vos. Protocols and procedures. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0015.

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Acute leukaemia: investigations - Platelet reactions and refractoriness - Prophylactic regimen for neutropenic patients - Guidelines for use of IV antibiotics in neutropenic patients - Treatment of neutropenic sepsis: source unknown - Treatment of neutropenic sepsis: source known/suspected - Prophylaxis for patients treated with purine analogues - Tumour lysis syndrome - Administration of chemotherapy - Antiemetics for chemotherapy - Intrathecal chemotherapy - Management of extravasation - Specific procedures after extravasation of cytotoxics commonly used in haematology - Anticoagulation ther
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15

Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Mammit Kaur. Protocols and procedures. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0015_update_001.

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Acute leukaemia: investigations - Platelet reactions and refractoriness - Prophylactic regimen for neutropenic patients - Guidelines for use of IV antibiotics in neutropenic patients - Treatment of neutropenic sepsis: source unknown - Treatment of neutropenic sepsis: source known/suspected - Prophylaxis for patients treated with purine analogues - Tumour lysis syndrome - Administration of chemotherapy - Antiemetics for chemotherapy - Intrathecal chemotherapy - Management of extravasation - Specific procedures after extravasation of cytotoxics commonly used in haematology - Anticoagulation ther
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