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Artykuły w czasopismach na temat "Airway (Medicine) Muscles Physiology Sex differences"

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Chang, Herng-Yu Sucie, and Wayne Mitzner. "Sex differences in mouse models of asthma." Canadian Journal of Physiology and Pharmacology 85, no. 12 (December 2007): 1226–35. http://dx.doi.org/10.1139/y07-116.

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Differences in disease susceptibility and prognosis between men and women are known to occur in the incidence and development of neurodegenerative, cardiovascular, and immunological disorders. In the lung there are also sex-based differences in the incidence, prevalence, and pathogenesis of lung cancer, cystic fibrosis, COPD, and asthma. In the general population, sex-based differences in asthma have been shown by epidemiologic studies, but unfortunately these studies are not consistent in their conclusions. This variability in human epidemiological studies justifies the need for more focused
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Kalidhindi, Rama Satyanarayana Raju, Niyati A. Borkar, Nilesh Sudhakar Ambhore, Christina M. Pabelick, Y. S. Prakash, and Venkatachalem Sathish. "Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?" American Journal of Physiology-Lung Cellular and Molecular Physiology 319, no. 5 (November 1, 2020): L843—L847. http://dx.doi.org/10.1152/ajplung.00391.2020.

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The incidence, severity, and mortality of ongoing coronavirus infectious disease 19 (COVID-19) is greater in men compared with women, but the underlying factors contributing to this sex difference are still being explored. In the current study, using primary isolated human airway smooth muscle (ASM) cells from normal males versus females as a model, we explored the effect of estrogen versus testosterone in modulating the expression of angiotensin converting enzyme 2 (ACE2), a cell entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using confocal imaging, we found tha
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Dominelli, Paolo B., and Yannick Molgat-Seon. "Sex, gender and the pulmonary physiology of exercise." European Respiratory Review 31, no. 163 (January 12, 2022): 210074. http://dx.doi.org/10.1183/16000617.0074-2021.

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In this review, we detail how the pulmonary system's response to exercise is impacted by both sex and gender in healthy humans across the lifespan. First, the rationale for why sex and gender differences should be considered is explored, and then anatomical differences are highlighted, namely that females typically have smaller lungs and airways than males. Thereafter, we describe how these anatomical differences can impact functional aspects such as respiratory muscle energetics and activation, mechanical ventilatory constraints, diaphragm fatigue, and pulmonary gas exchange in healthy adults
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Kalidhindi, Rama Satyanarayana Raju, Nilesh Sudhakar Ambhore, Premanand Balraj, Taylor Schmidt, M. Nadeem Khan, and Venkatachalem Sathish. "Androgen receptor activation alleviates airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 5 (May 1, 2021): L803—L818. http://dx.doi.org/10.1152/ajplung.00441.2020.

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Epidemiological studies demonstrate an apparent sex-based difference in the prevalence of asthma, with a higher risk in boys than girls, which is reversed postpuberty, where women become more prone to asthma than men, suggesting a plausible beneficial role for male hormones, especially androgens as a regulator of pathophysiology in asthmatic lungs. Using a murine model of asthma developed with mixed allergen (MA) challenge, we report a significant change in airway hyperresponsiveness (AHR), as demonstrated by increased thickness of epithelial and airway smooth muscle layers and collagen deposi
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Ford, Lincoln E. "Plasticity in airway smooth muscle: an update." Canadian Journal of Physiology and Pharmacology 83, no. 10 (October 1, 2005): 841–50. http://dx.doi.org/10.1139/y05-089.

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At a similar meeting 10 years ago, we proposed (i) that the long functional range of some smooth muscles is accommodated by plastic alterations that place more myofilaments in series at longer lengths, (ii) that this plasticity is facilitated by myosin filament evanescence, with filaments dissociating partially during relaxation and reforming upon activation, and (iii) that filament lengthening during the rise of activation would cause velocity to fall. Since that meeting, we have accumulated a substantial body of evidence to support these proposals, as follows: (i) muscles develop nearly the
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Card, Jeffrey W., James W. Voltz, Catherine D. Ferguson, Michelle A. Carey, Laura M. DeGraff, Shyamal D. Peddada, Daniel L. Morgan, and Darryl C. Zeldin. "Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 4 (April 2007): L908—L914. http://dx.doi.org/10.1152/ajplung.00407.2006.

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A sex disparity in airway responsiveness to cholinergic stimulation has been observed in laboratory mice in that males are considerably more responsive than females, but the basis for this difference is unclear. In this report, we demonstrate that male sex hormones promote murine airway responsiveness to cholinergic stimulation via vagus nerve-mediated reflex mechanisms. In tissue bath preparations, no sex-based differences were observed in the contractile responses of isolated tracheal and bronchial ring segments to carbachol, indicating that the mechanism(s) responsible for the in vivo sex d
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Kurti, Stephanie P., Sam R. Emerson, Joshua R. Smith, Sara K. Rosenkranz, Samantha A. Alexander, Garrett M. Lovoy, and Craig A. Harms. "Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls." Applied Physiology, Nutrition, and Metabolism 43, no. 5 (May 2018): 497–503. http://dx.doi.org/10.1139/apnm-2017-0565.

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Development of late-onset respiratory diseases is associated with elevated 8-isoprostane, a marker of oxidative stress, in the airways. However, sex differences exist in development of these diseases. Using an exhaustive exercise bout as a physiological stressor may elucidate whether there is a sex difference with aging in pre- to postexercise airway 8-isoprostane generation. The purpose of this study was to determine whether older women exhibit a greater airway 8-isoprostane response to exhaustive exercise compared with older men and younger controls. Thirty-six individuals completed the stud
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Salminen, A., P. Saari, and M. Kihlström. "Age- and sex-related differences in lipid peroxidation of mouse cardiac and skeletal muscles." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 89, no. 4 (January 1988): 695–99. http://dx.doi.org/10.1016/0305-0491(88)90310-0.

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Pascoe, Christopher D., Sujata Basu, Jacquie Schwartz, Mario Fonseca, Shana Kahnamoui, Aruni Jha, Vernon Dolinsky, and Andrew J. Halayko. "Maternal diabetes promotes offspring lung dysfunction and inflammation in a sex-dependent manner." American Journal of Physiology-Lung Cellular and Molecular Physiology 322, no. 3 (March 1, 2022): L373—L384. http://dx.doi.org/10.1152/ajplung.00425.2021.

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Exposure to maternal diabetes is increasingly recognized as a risk factor for chronic respiratory disease in children. It is currently unclear; however, whether maternal diabetes affects the lung health of male and female offspring equally. This study characterizes the sex-specific impact of a murine model of diet-induced gestational diabetes (GDM) on offspring lung function and airway inflammation. Female adult mice are fed a high-fat (45% kcal) diet for 6 wk prior to mating. Control offspring are from mothers fed a low-fat (10% kcal) diet. Offspring were weaned and fed a chow diet until 10 w
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Stock, Matt S., Dustin J. Oranchuk, Adam M. Burton, and David C. Phan. "Age-, sex-, and region-specific differences in skeletal muscle size and quality." Applied Physiology, Nutrition, and Metabolism 45, no. 11 (November 2020): 1253–60. http://dx.doi.org/10.1139/apnm-2020-0114.

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Ultrasonography-derived cross-sectional area (CSA) and echo intensity (EI) are increasingly utilized by investigators to study muscle size and quality, respectively. We sought to examine age, sex, and region (proximal, middle, distal) differences in vastus lateralis and rectus femoris CSA and EI, and determine whether correction for subcutaneous fat thickness influences the magnitude of EI differences. Fifteen younger men (mean age = 23 years), 15 younger women (aged 21 years), 11 older men (aged 74 years), and 15 older women (aged 70 years) participated. Clear differences were observed among
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Rozprawy doktorskie na temat "Airway (Medicine) Muscles Physiology Sex differences"

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Jordan, Amy Selina. "The control of respiration and upper airway muscle activity in healthy young men and women." Title page, table of contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phj812.pdf.

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"May 2002." Bibliography: leaves 123-144. Aspects of the control of ventilation and an upper airway dilator muscle (genioglossus) are compared between healthy men and women, in an attempt to identify a gender difference that may contribute to the high male prevalence of sleep apnea.
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Jordan, Amy Selina. "The control of respiration and upper airway muscle activity in healthy young men and women / by Amy Jordan." Thesis, 2002. http://hdl.handle.net/2440/21859.

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"May 2002."<br>Bibliography: leaves 123-144.<br>xiv, 144 leaves : ill. ; 30 cm.<br>Aspects of the control of ventilation and an upper airway dilator muscle (genioglossus) are compared between healthy men and women, in an attempt to identify a gender difference that may contribute to the high male prevalence of sleep apnea.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 2002
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