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Rozprawy doktorskie na temat „Allergen microarrays”

Autor: Grafiati

Data publikacji: 21 września 2024

Data aktualizacji: 31 lipca 2025

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1

Martinroche, Guillaume. "Quantification et caractérisation des maladies auto-immunes et allergiques à l'aide de méthodes d'apprentissage profond." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0154.

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Les outils d’aide au diagnostic utilisant l’intelligence artificielle (IA) aideront très prochainement les praticiens à proposer une médecine plus personnalisée et de précision pour les patients. Les maladies auto-immunes et allergiques (MAIA) sont le parfait exemple de maladies au diagnostic complexe pouvant bénéficier de ces outils. Les anticorps antinucléaires (ANA) sur les cellules épithéliales humaines (HEp-2) sont la référence pour le dépistage et le diagnostic des maladies auto-immunes (MAI). Pour une harmonisation des pratiques de laboratoires et cliniques, une lecture et une classific

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Ardizzoni, Andrea. "Allergome microarray for the detection of total repertoire of allergen-specific IgE human serum." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427750.

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Hamed, Aljali. "Development of IgE microarray assays for classification of allergic individuals." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37431/.

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Allergic reactions are pathological immune reactions against common, harmless environmental proteins, termed “allergens”. Type I hypersensitivity reactions are mediated by IgE antibodies; these reactions are the most prevalent, affecting all ages and both genders to almost the same extent. This form of allergic reaction is distributed widely affecting more than 25% of the population in the industrial world. The increased incidence of IgE-mediated allergy is thought to be a combination of environmental and genetic factors, each account for about 50%. The effects associated with this disease may

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Erkers, Julia. "Towards automatic smartphone analysis for point-of-care microarray assays." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280663.

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Poverty and long distances are two reasons why some people in the third world countries hasdifficulties seeking medical help. A solution to the long distances could be if the medical carewas more mobile and diagnostically tests could be performed on site in villages. A new pointof-care test based on a small blood shows promising results both in run time and mobility.However, the method still needs more advanced equipment for analysis of the resultingmicroarray. This study has investigated the potential to perform the analysis within asmartphone application, performing all steps from image capt

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Bosco, Anthony. "Identification of novel genes associated with allergen-driven T cell activation in human atopics." University of Western Australia. School of Paediatrics and Child Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0023.

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[ Truncated abstract ] Atopic diseases such as asthma are thought to be driven to a significant extent by T helper memory cells which are programmed to respond in a harmful way to environmental allergens (e.g. house dust mite). Previous studies in humans and in animal models have established that activation of TH2 cytokine genes in T memory responses to allergens is central to the disease process. However, only a subset of atopics harbouring a TH2-memory response phenotype manifests clinical symptoms of disease. Moreover, clinical trials with TH2 antagonists in atopic patients have proven dis

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Wang, Xiaowei. "Development of a detection system towards a basophil-microarray for the diagnosis of allergies." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14187/.

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Allergic responses are mainly mediated by immunoglobulin E (IgE) and mast cells or basophils expressing the high-affinity IgE receptor FcεRI. Cross-linking of FcεRI and IgE complexes with allergen induces basophil degranulation and release of inflammatory chemical mediators, leading to clinical symptoms. Common allergy diagnostic tests such as ImmunoCAP, focused on the measurement of specific IgE in patients, commonly lead to misdiagnosis. The allergen-specific IgE in patients’ sera might not always lead to FcεRI cross-linking on mast cells or basophils, resulting in no related clinical sympto

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Mallmann, Stefanie [Verfasser], and Ralf S. [Akademischer Betreuer] Müller. "Untersuchung der Testreaktionen in Allergen-Microarray und Intradermaltest von Hunden mit atopischer Dermatitis unter Berücksichtigung der allergisch bedingten Juckreizsymptomatik / Stefanie Mallmann ; Betreuer: Ralf S. Müller." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1216827230/34.

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Pascal, i. Capdevila Mariona. "Allergenic protein and epitope recognition in food allergy: a new perspective for the molecular and clinical characterization of shellfish and lipid transfer protein allergy / Reconeixement de proteïnes i epítops al•lergènics en al•lèrgia alimentaria: una nova perspectiva per a la caracterització clínica i molecular de l’al•lèrgia al marisc i a les proteïnes de transferència de lípids." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/84070.

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Currently food allergy diagnostic tests are not able to predict clinical reactivity in sensitized patients (those with specific IgE against a particular allergen). Traditionally, allergy diagnostic tests used complete extracts of allergenic sources containing multiple molecules, some allergic and others not. This greatly limits the accuracy in the diagnosis and identification of possible allergic reactions to different foods by the existence of cross reactivity. Through the last decades, thanks to advances in the characterization of allergens at molecular level, the concept of Component-Based

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9

ARASI, STEFANIA. "Reliable mite-specific microarray for testing IgE antibodies in nasal secretions." Doctoral thesis, 2017. http://hdl.handle.net/11570/3121575.

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Methods to measure allergen-specific immunoglobulin E (sIgE) at nasal level in patients with allergic rhinitis are currently of great interest for many reasons, such as the evidence for local production of IgE in the nasal mucosa. Nasal secretions are easily collected with various non-invasive procedures and suitable for IgE measurements. Nevertheless, IgE “classic” assays, based on immunoenzymatic methods and allergen extracts, require large volumes and are inefficient in detecting the low amounts of IgE in NasSec. In this study, IgE antibodies to 15 allergen molecules of Dermatophagoides pte

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10

Pereira, Cátia Liliana Morais. "Characterization of allergens from several tree nuts and their role in plant food allergy." Master's thesis, 2013. http://hdl.handle.net/10451/11516.

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Tese de mestrado, Controlo da Qualidade e Toxicologia dos Alimentos, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Food allergies are a common issue in western countries. In the last decade, these diseases has increased significantly, and nowadays it is estimated that affects 2-8% of the population. Within the food allergies, plant food is the most frequent in adult population and the most part of the plant food allergens belong to protein families with defense or storage functions. Among plant food allergies there is a special interest in tree nut allergy. In the course of history,

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11

Chou, Shan-Ying, and 周珊霙. "An integrated microfluidic system for automating multiplex allergy microarrays." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/jhbrg6.

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碩士<br>國立清華大學<br>生物醫學工程研究所<br>105<br>This study reports an integrated automatic microfluidic system for detection of allergy in a microarray platform. Nowadays, allergy is very common in the world. It is a response of the human immune system to antigens in the surroundings. However, detection for allergy requires tedious manual operation, well-trained technicians and a relatively labor-intensive process. In the study, an integrated microfluidic system has been developed by combining several microfluidic techniques and microarray chips. Our previous experiments showed that a microfluidic system

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Tumes, Damon John. "Factors associated with mouse strain-dependent susceptibility to pathology in models of allergic asthma." Thesis, 2009. http://hdl.handle.net/2440/56533.

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Although exposed to similar environmental stimuli, not all humans develop asthma. Similarly, mouse strains vary in the degree of pathophysiology seen following induction of experimental asthma. A model involving immunization and aerosol challenge with ovalbumin (OVA) was used to investigate factors that may confer strain-dependent resistance or susceptibility to pathology. BALB/c and C57BL/6 mice developed many features of human asthma including inflammation, mucus production and airway obstruction. In contrast, CBA/Ca mice were relatively resistant to development of disease. This was despite

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Tumes, Damon John. "Factors associated with mouse strain-dependent susceptibility to pathology in models of allergic asthma." 2009. http://hdl.handle.net/2440/56533.

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Although exposed to similar environmental stimuli, not all humans develop asthma. Similarly, mouse strains vary in the degree of pathophysiology seen following induction of experimental asthma. A model involving immunization and aerosol challenge with ovalbumin (OVA) was used to investigate factors that may confer strain-dependent resistance or susceptibility to pathology. BALB/c and C57BL/6 mice developed many features of human asthma including inflammation, mucus production and airway obstruction. In contrast, CBA/Ca mice were relatively resistant to development of disease. This was despite

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14

Jin, Saihong. "Specific IgE profiling of 52 allergens in sensitized individuals using a new protein microarray technology." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014914880&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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15

Paul, Jasmin. "A New Reclassification Method for Highly Uncertain Microarray Data in Allergy Gene Prediction." Thesis, 2012. http://hdl.handle.net/10214/3486.

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The analysis of microarray data is a challenging task because of the large dimensionality and small sample size involved. Although a few methods are available to address the problem of small sample size, they are not sufficiently successful in dealing with microarray data from extremely small (~<20) sample sizes. We propose a method to incorporate information from diverse sources to analyze the microarray data so as to improve the predictability of significant genes. A transformed data set, including statistical parameters, literature mining and gene ontology data, is evaluated. We performed

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Shiue, Horng-Sheng, and 薛宏昇. "DNA Microarray Analysis of the Effect in Patients Treated with Acupuncture for Allergic Rhinitis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/36965802441145142529.

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博士<br>臺北醫學大學<br>醫學科學研究所<br>97<br>Allergic rhinitis affects approximately 30% of adults and up to 40% of children in industrialized societies. Medicines available for relief of allergic rhinitis symptoms include antihistamines, decongestants, leukotriene inhibitors, topical hormones and corticosteroids. However, the negative side effects of anti-allergic medicines cause many allergic rhinitis patients to choose traditional Chinese medical treatments - such as taking Chinese herbs or treatment with acupuncture. Acupuncture therapy corrects the equilibrium deviation using the bi-directional regul

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Tsai, Hsuanhui Lydia, and 蔡琁卉. "A retrospective analysis of canine allergens profile in Taiwan: Detection of specific IgE in dog sera using protein chip microarray, and the identification of major proteins in brewer’s yeast." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/21921412511993670109.

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碩士<br>臺灣大學<br>獸醫學研究所<br>98<br>Allergy has always played an important role in canine skin related diseases. The prevalence of canine allergic dermatitis (CAD) in the canine population was also estimated to be around 3-15%. The purpose of this study is to analyze and understand the type of allergens causing CAD in Taiwan. We analyzed 505 results from Excelsior bio-system’s protein chip microarray 62 item canine allergy test collected from May of 2006 to February of 2008. The result showed 80% of the cases had at least one positive result to the 62 items tested, and 54.06% of the dogs had at

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