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Artykuły w czasopismach na temat „Alpha-blockers”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Barbalias, George A. "Why Alpha-Blockers in Prostatitis?" European Urology Supplements 2, no. 2 (2003): 27–29. http://dx.doi.org/10.1016/s1569-9056(02)00197-5.

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Bos, Derek, and Anil Kapoor. "Update on medical expulsive therapy for distal ureteral stones: Beyond alpha-blockers." Canadian Urological Association Journal 8, no. 11-12 (2014): 442. http://dx.doi.org/10.5489/cuaj.2472.

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Medical expulsive therapy (MET) has been described as an effective conservative treatment option in the initial management of small distal ureteral stones. Therapies that have been investigated include alpha-blockers, calcium channel blockers, corticosteroids, and most recently phosphodiesterase-5 inhibitors (PDE5) inhibitors. While alpha-blockers are currently the only recommended monotherapy, corticosteroids have received increased attention as a potential useful adjunct in the medical management of distal stones. PDE5 inhibitors are a novel treatment alternative, requiring further investiga

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3

Koski, Renee R., and William H. Zufall. "Efficacy and Safety of Alpha-Blockers for Kidney Stones in Adults." Journal of Pharmacy Technology 34, no. 2 (2017): 54–61. http://dx.doi.org/10.1177/8755122517750398.

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Objective: To review the literature for α-blocker treatment of kidney stones. Data Sources: PubMed search performed November 15, 2017, using the following search terms: alpha-blocker, alfuzosin, silodosin, or tamsulosin AND kidney or ureteral stones. Additional studies found through references of primary and tertiary literature. Inclusion criteria included English language, randomized controlled trials (not included in meta-analyses), and meta-analyses evaluating US available alpha-blockers as medical expulsive therapy with or without lithotripsy in adults with renal or ureteral stones, and no

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4

Knyazev, O. V., A. V. Kagramanova, M. Yu Zvyaglova та ін. "Эффективность препарата устекинумаб у пациента с язвенным колитом после неудачи терапии блокаторами ФНО-альфа, блокатором янус-киназ и ингибитором альфа-4-бета-7-интегрина". Effective Pharmacotherapy 16, № 30 (2020): 24–31. http://dx.doi.org/10.33978/2307-3586-2020-16-30-24-31.

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On specific examples the article demonstrates the clinical efficacy of ustekinumab in severe ulcerative colitis after failure of therapy with tumor necrosis factor alpha blockers, Janus kinase blockers, and alpha-4-beta-7-integrin inhibitors.

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Bapir, Rawa, Kamran Hassan Bhatti, Ahmed Eliwa, et al. "Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis." Archivio Italiano di Urologia e Andrologia 94, no. 2 (2022): 252–63. http://dx.doi.org/10.4081/aiua.2022.2.252.

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Background: Alpha-adrenoreceptor antagonists or alpha-blockers are used in the treatment of hypertension, in the therapy of benign prostatic hyperplasia and in medical expulsive treatment of ureteral stones. These agents may affect the sexual function, with differences between drugs within the same class, depending on their selectivity for receptor subtypes. The aim of this review was to analyze the effects of alpha-blockers on sexual function. Materials and methods: We conducted a systematic review and meta-analysis by searching PubMed, EMBASE and other databases for randomized controlled tri

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6

Debruyne, Frans M. J. "Alpha blockers: are all created equal?" Urology 56, no. 5 (2000): 20–22. http://dx.doi.org/10.1016/s0090-4295(00)00744-5.

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Das, Sambhunath, Pankaj Kumar, Usha Kiran, and Balram Airan. "Alpha blockers: A relook at phenoxybenzamine." Journal of the Practice of Cardiovascular Sciences 3, no. 1 (2017): 11. http://dx.doi.org/10.4103/jpcs.jpcs_42_16.

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Kirby, Roger. "LUTS, alpha-blockers and men's health." Trends in Urology & Men's Health 7, no. 6 (2016): 14–16. http://dx.doi.org/10.1002/tre.551.

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Jounela, A. J., E. Kanniainen, and M. Lilja. "Interaction between clonidine and alpha blockers." Clinical Cardiology 8, no. 12 (1985): 641–42. http://dx.doi.org/10.1002/clc.4960081206.

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Sarhad Khan, Romana Bibi, Abdul Ullah, et al. "Lower Ureteric Stone Expulsion under the Effect of Alpha Blockers: A Clinical Trial over Alpha Blockers Efficacy." Journal of Saidu Medical College, Swat 12, no. 3 (2022): 138–42. http://dx.doi.org/10.52206/jsmc.2022.12.3.707.

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Background: The ureters account for over 20% of urinary tract stones. The lifetime chance of having urinary calculi is between 5-12%, and men are more likely than women to develop them. There are a variety of minimally invasive interventional (ESWL and Ureteroscopy) and expectant options. However, the optimum therapy is mostly determined by the type and size of the stone, as well as the stone's location and the patient's demands. We do minimal invasive procedures like ureterostomy and ESWL to remove stone in ureter with some complications. Objective: To determine the efficacy of alpha bl

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11

Jazayeri, Seyed Behzad, Young S. Kwon, Russell McBride, et al. "The Modulating Effects of Benign Prostate Enlargement Medications on Upgrading Predictors in Patients with Gleason 6 at Biopsy." Current Urology 10, no. 2 (2016): 97–104. http://dx.doi.org/10.1159/000447159.

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Background: Upgrading following prostate biopsy is very common in clinical practice. This study investigated whether the use of 5-alpha reductase inhibitors (ARI) and alpha blockers affect known clinical predictors of Gleason score upgrading or not. Materials and Methods: A retrospective study on 998 patients treated with robotic assisted laparoscopic prostatectomy for clinically localized biopsy Gleason score 6 prostate cancer were studied. The logarithm of prostate specific antigen concentration, prostate size and tumor volume were compared on the basis of the medication history of 5-ARIs an

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12

Kusumowardani, Alivia Retra. "60. Response to Revascularization in Resistant Hypertension Related to Renal Artery Stenosis: A Systematic Review of Case Reports." Journal of Hypertension 42, Suppl 2 (2024): e16. http://dx.doi.org/10.1097/01.hjh.0001027020.33700.fa.

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Background: Treatment for resistant hypertension related to renal artery stenosis is focused mainly through medical therapy. Revascularization is not routinely recommended due to its limited advantage over medical therapy. However, there have been reported cases of revascularization that has improved the patients’ outcome. Objective: This review of case reports is to identify the characteristics of patients who underwent revascularization and their response after follow up. Methods: A search through the Medline database for case reports of revascularization in renal artery stenosis published d

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13

Ayyad, Rezk R., Ahmed M. Mansour, Ahmed M. Nejm, Yasser Abdel Allem Hassan, and Ahmed R. Ayyad. "Drug Targeting Consider a Lead for Drug Discovery for Example Drug Antagonists." Journal of Progress in Engineering and Physical Science 3, no. 4 (2024): 1–8. https://doi.org/10.56397/jpeps.2024.12.01.

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The adrenergic compounds are chemical structures related to Adrenaline and Noradrenaline e.g., isoprenaline and terbutaline, when want to change in the chemical structure of adrenergic will lead us to an adrenergic blocking agents e.g., Alpha blockers and Beta blockers (prazosin, terazosin, propranolol and atenolol). Also, cholinergic agents especially direct cholinergics are chemical structures related to Acetylcholine which when manipulate of the Ach. We obtain anti-cholinergic agents like neostigmine, physostigmine, pilocarpine… etc. All the blockers are examples of drug discovery depends o

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14

Mendis, S. "Calcium channel blockers and alpha-blockers in hypertension: what is the evidence ?" Ceylon Medical Journal 45, no. 4 (2014): 152. http://dx.doi.org/10.4038/cmj.v45i4.6555.

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Hsueh, Chen-Hsun, Li-Wen Chang, Kun-Yuan Chiu, Sheng-Chun Hung, Jun-Peng Chen, and Jian-Ri Li. "Chronic kidney disease, preoperative use of antispasmodics and lower resected prostate volume ratios are risk factors for postoperative use of adrenergic Alpha-blockers and antispasmodics." PLOS ONE 18, no. 3 (2023): e0282745. http://dx.doi.org/10.1371/journal.pone.0282745.

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Objectives Transurethral resection of prostate (TURP) and laser prostate surgery are common surgeries for benign prostate hyperplasia (BPH). We conducted an investigation using hospital database to evaluate the clinical factors associated with post-operative usage of alpha-blockers and antispasmodics. Methods This study was conducted using retrospective clinical data from the hospital database, which contained newly diagnosed BPH patients between January 2007 and December 2012 who subsequently received prostate surgery. The study end-point was the use of alpha-blockers or antispasmodics for at

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16

N, Imdad Ali, Paresh Sankhe, Ravishankar T.H.S., and Jayaprakasha Gangadharaiah. "A Prospective Comparative Study to Evaluate the Effect of Alpha Blocker on Ureteric Orifice for Ease of Ureteroscopy in Patients of Ureteric Calculus and BPH." Journal of Evidence Based Medicine and Healthcare 7, no. 49 (2020): 2888–91. http://dx.doi.org/10.18410/jebmh/2020/591.

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BACKGROUND The selective alpha-blockers are widely used in the clinical treatment for ureteral stones as MET (Medical Expulsive Therapy). American Urological Association and European Association of Urology, strongly recommend that patients with ureteral stones be alpha-blockers to promote stone passage. Due to the physiological effect of alpha-blockers on the ureter, researchers hypothesized that the use of alphablockers before ureteroscopy may help during the Ureteroscopic procedures, making it easier and safer. One critical step in doing ureteroscopy is directing scope into vesicoureteral ju

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17

Thaulow, Erik, and Sigurd Nitter-Hauge. "Antihypertensive Therapy and Blood Lipids: Alpha-Blockers." Scandinavian Journal of Clinical and Laboratory Investigation 50 (1990): 45–48. http://dx.doi.org/10.3109/00365519009090543.

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&NA;. "Alpha-blockers/finasteride: no benefit in ED." Reactions Weekly &NA;, no. 968 (2003): 3. http://dx.doi.org/10.2165/00128415-200309680-00005.

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Thaulow, Erik, and Sigurd Nitter-Hauge. "Antihypertensive Therapy and Blood Lipids: Alpha-Blockers." Scandinavian Journal of Clinical and Laboratory Investigation 50, sup199 (1990): 45–48. http://dx.doi.org/10.1080/00365519009090543.

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Sica, Domenic A. "Alpha 1 ‐Adrenergic Blockers: Current Usage Considerations." Journal of Clinical Hypertension 7, no. 12 (2005): 757–62. http://dx.doi.org/10.1111/j.1524-6175.2005.05300.x.

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Irani, Jacques. "Are All Alpha-Blockers Created the Same?" European Urology 49, no. 3 (2006): 420–22. http://dx.doi.org/10.1016/j.eururo.2005.12.032.

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Kim, Sung Jin, Sung Gon Park, Sahyun Pak, Young Goo Lee, Sung Tae Cho, and Ohseong Kwon. "Predictive factors for alpha blocker use after transurethral prostatectomy: Can preoperative urodynamic outcome predict alpha blocker medication after surgery?" PLOS ONE 17, no. 9 (2022): e0274399. http://dx.doi.org/10.1371/journal.pone.0274399.

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Objective To analyze the diagnostic value of conducting urodynamic study (UDS) and show predictors for alpha blocker use 12 months after transurethral prostatectomy. Materials and methods Our study includes 406 participants that had a transurethral prostatectomy at our hospital between 2010 and 2019. All participants took alpha blockers for more than a month. We collected the participants’ preoperative international prostatic symptom score (IPSS), uroflowmetry, transrectal ultrasound, and serum prostatic antigen (PSA) level. A total of 254 patients conducted UDS. After surgery, participants vi

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Serani Sesari, Saras, Widi Atmoko, Ponco Birowo, and Nur Rasyid. "The efficacy of adjunctive alpha-blockers on ureteroscopy procedure for ureteral stones: a systematic review and meta-analysis." F1000Research 10 (May 28, 2021): 427. http://dx.doi.org/10.12688/f1000research.52072.1.

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Background: Urolithiasis cases are a common condition, and the number is still growing today. The prevalence of urinary tract stones globally currently ranges from 2-20% with a recurrence rate of around 50%. The present study aims to investigate the efficacy of adjunctive alpha-blockers in improving the success rate of ureteroscopy (URS) procedure for urolithiasis. Methods: We reviewed articles obtained from MEDLINE, CENTRAL, CINAHL, and Elsevier from 14 August to 9 September 2020, comparing alpha-blockers as adjunctive therapy, versus either a placebo or no drug at all, in post-URS urolithias

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Serani Sesari, Saras, Widi Atmoko, Ponco Birowo, and Nur Rasyid. "The efficacy of adjunctive alpha-blockers on ureteroscopy procedure for ureteral stones: a systematic review and meta-analysis." F1000Research 10 (April 12, 2022): 427. http://dx.doi.org/10.12688/f1000research.52072.2.

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Background: Urolithiasis cases are a common condition, and the number is still growing today. The prevalence of urinary tract stones globally currently ranges from 2-20% with a recurrence rate of around 50%. The present study aims to investigate the efficacy of adjunctive alpha-blockers in improving the success rate of ureteroscopy (URS) procedure for urolithiasis. Methods: We reviewed articles obtained from MEDLINE, CENTRAL, CINAHL, and Elsevier from 14 August to 9 September 2020, comparing alpha-blockers as adjunctive therapy, versus either a placebo or no drug at all, in post-URS urolithias

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Jeon, Nakyung, and Seungjae Jung. "Analysis of Claims Data for Benign Prostate Hyperplasia Drugs: Prescription Pattern Assessment of Alpha Blockers (AB) and 5-alpha Reductase Inhibitors (5ARI)." Yakhak Hoeji 68, no. 6 (2024): 502–8. https://doi.org/10.17480/psk.2024.68.6.502.

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Povetkin, S. V., V. I. Gikavyj, N. G. Bachinski, et al. "Comparative Pharmacoepidemiological Assessment of Antihypertensive Drugs Administration Structure in Pregnant Women in Routine Medical Practice in Kursk and Chisinau." Rational Pharmacotherapy in Cardiology 18, no. 5 (2022): 571–77. http://dx.doi.org/10.20996/1819-6446-2022-10-02.

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Aim. To study the structure of antihypertensive drugs prescription in pregnant women in routine practice in Kursk and Chisinau.Material and methods. The study design was observational descriptive cross-sectional. Authors conducted a survey of doctors in medical organizations in Kursk and Chisinau in 2017-2018.Results. Respondents from Kursk and Chisinau preferred methyldopa in prescriptions of central alpha-adrenergic receptor agonists. Doctors from Chisinau used clonidine in 14.3% of cases. The leading place in the group of calcium channel blockers belonged to short-acting nifedipine. Among b

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Leontyeva, I. V., L. A. Balykova, and A. V. Kudashova. "Treatment of emergency conditions (hypertensive crisis) in children with arterial hypertension." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 65, no. 3 (2020): 147–52. http://dx.doi.org/10.21508/1027-4065-2020-65-3-147-152.

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The article presents a modern classification of hypertensive crises in children. The authors describe detailed tactics of emergency care of hypertensive crises in children. They consider the treatment of hypertensive crises with beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, alpha blockers. The article contains a table of the main antihypertensive medications used to treat hypertensive crises.

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Sabharwal, Sudhir, and Narita Jamwal. "Efficacy of Alpha-1 Adrenergic Blockers in the Management of Benign Prostatic Hyperplasia." Asian Journal of Medical Research 8, no. 2 (2019): SG01—SG05. http://dx.doi.org/10.21276/ajmr.2019.8.2.sg1.

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Narayan Singh, Sanket, Manoj Biswas, Ankur Mittal, et al. "Comparing the effect of Alpha blocker (Silodosin) and Phosphodiesterase type 5 inhibitor (Tadalafil) in benign prostate hyperplasia patients with lower urinary tract symptoms: a single centre study." International Surgery Journal 5, no. 5 (2018): 1866. http://dx.doi.org/10.18203/2349-2902.isj20181599.

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Background: Benign prostatic hyperplasia (BPH) is a histologic diagnosis that refers to the proliferation of smooth muscle and epithelial cells within the prostatic transition zone. The aim of this systematic review is to determine the comparative effectiveness and safety of phosphodiesterase 5 inhibitors (PDE5-Is) and alpha blockers used alone or in combination for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).Methods: We analyzed 54 patients of BPH with LUTS with baseline IPSS, Qmax and PVR over one-year period. They were randomized equally in

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Reid, John L. "Drug Treatment—Antihypertensive Drugs—The Present Role of Beta Blockers and Alpha Blockers." Clinical and Experimental Hypertension 21, no. 5-6 (1999): 815–21. http://dx.doi.org/10.3109/10641969909061011.

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Beshara, Peter, Quratulanne Jan, Hammad Qureshi, and Osama Mohamed. "Are alpha-blockers effective therapy for ureteral stones?" Evidence-Based Practice 18, no. 6 (2015): 14. http://dx.doi.org/10.1097/01.ebp.0000540991.86581.5c.

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Staněk, Roman. "Role of alpha blockers in treating obstructive uropathy." Urologie pro praxi 21, no. 4 (2021): 150–54. http://dx.doi.org/10.36290/uro.2020.037.

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Katz, Philippe. "Alpha-1-Blockers for Obstructive Salivary Gland Diseases." Otolaryngology–Head and Neck Surgery 143, no. 2_suppl (2010): P156—P157. http://dx.doi.org/10.1016/j.otohns.2010.06.258.

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Kruep, Eric J., Bridgett B. Goodwin, and Sham Chaudhari. "Evaluation of Recent Trends in Treatment Patterns Among Men With Benign Prostatic Hyperplasia." American Journal of Men's Health 7, no. 3 (2012): 214–19. http://dx.doi.org/10.1177/1557988312469245.

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Although there is an abundance of evidence regarding clinical efficacy and safety of benign prostatic hyperplasia (BPH) treatment, real-world evidence is lacking for pharmacotherapy utilization and trends. It is unclear how evidence demonstrating the efficacy of combination 5-alpha reductase inhibitors and alpha blockers for improving symptoms and reducing risk of disease progression translates into real-world practice for the treatment of BPH. A retrospective study of a database was conducted to describe pharmacotherapy utilization/trends in the treatment of BPH among patients in the managed

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LEPOR, HERBERT. "The Emerging Role of Alpha Antagonists in the Therapy of Benign Prostatic Hyperplasia." Journal of Andrology 12, no. 6 (1991): 389–94. http://dx.doi.org/10.1002/j.1939-4640.1991.tb00281.x.

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AbstractThe rationale for using alpha blockade to treat benign prostatic hyperplasia (BPH) is based on the physiology and pharmacology of prostate smooth muscle. Approximately 20% of the area density of the prostate adenoma is smooth muscle. In vitro isometric tension studies have demonstrated that the contractile properties of the human prostate adenoma are mediated primarily by alpha1 adrenoceptors. Alpha blockers presumably decrease the resistance along the prostatic urethra by relaxing the smooth muscle component of the prostate. Over the past 14 years, at least 16 clinical trials have con

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Baykal, Yavuz, M. Ilker Yilmaz, Turgay Celik, et al. "Effects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress." Journal of Hypertension 21, no. 6 (2003): 1207–11. http://dx.doi.org/10.1097/00004872-200306000-00022.

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Gottlieb, Michael, and Damali Nakitende. "Comparison of Tamsulosin, Nifedipine, and Placebo for Ureteric Colic." CJEM 19, no. 2 (2015): 156–58. http://dx.doi.org/10.1017/cem.2015.105.

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Clinical questionDo calcium channel blockers or alpha blockers improve renal stone passage when compared with placebo?Article chosenPickard R, Starr K, MacLennan G, et al. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet 2015;386(9991):25-31, doi: 10.1016/S0140-6736(15)60933-3.

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Yusuf, Muhlis, Niwanda Yogiswara, Muhammad Rifki Setiawan, Sirin Salsabila, Mohammad Ayodhia Soebadi, and Soetojo Wirjopranoto. "Preoperative alpha-blockers to facilitate ureteral access sheath (UAS) insertion: a systematic review and meta-analysis." Bali Medical Journal 12, no. 1 (2023): 291–98. http://dx.doi.org/10.15562/bmj.v12i1.4072.

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Background: Recent studies have proposed the use of preoperative alpha-blockers to facilitate urethral access sheath (UAS) placement, but the definite role of this practice is still unclear. We aimed to evaluate the efficacy and safety of alpha-blocker use for UAS placement in intrarenal endoscopic procedures. Methods: The course of this study followed the preferred reporting items for systematic review and meta-analyses guidelines. Articles investigating the use of preoperative alpha-blockers for patients who underwent intrarenal endoscopic procedures were systematically reviewed from PubMed,

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SARIKAYA, Kubilay, and Muhammed Arif İBİŞ. "Is there any effect of alpha-adrenergic blocker usage in preventing febrile urinary tract infections after prostate biopsy?" Journal of Health Sciences and Medicine 6, no. 1 (2023): 1–6. http://dx.doi.org/10.32322/jhsm.1138430.

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Purpose: To investigate whether the use of long term alpha-adrenergic blockers before biopsy has an effect on preventing febrile urinary tract infections (FUI) secondary to biopsy in patients undergoing prostate biopsy due to elevated prostate specific antigen (PSA). Material and Methods: The data of 2558 patients who underwent transrectal ultrasonography-guided prostate biopsy (TRUS+BX) due to elevated PSA in our clinic between January 2008 and July 2021 were analyzed retrospectively. The patients were divided into two groups as those who used alpha-blockers for a minimum of three month

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Kang, Tae Wook, Su Jin Kim, Ki Don Chang, Myung Ha Kim, and Hyun Chul Chung. "Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis." Therapeutic Advances in Urology 13 (January 2021): 175628722110536. http://dx.doi.org/10.1177/17562872211053679.

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Aims: The aim of this study was to evaluate the effects of alpha blockers in women with lower urinary tract symptoms. Methods: We conducted systematic review and meta-analysis on published a priori protocols. We searched multiple data sources for published and unpublished randomized controlled trials in any language. Primary outcomes included urologic symptom scores, quality of life, and overall adverse events. We performed meta-analysis using RevMan 5.3 and rated the certainty of evidence using Grading of Recommendations, Assessment, Development, and Evaluation. Results: Alpha blockers likely

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Sheklakova, M. N., I. A. Kappusheva, O. R. Katunina, M. M. Butareva, N. V. Samarova, and M. A. Nefedova. "Skin leiomyoma — clinical observation." Vestnik dermatologii i venerologii 89, no. 2 (2013): 62–66. http://dx.doi.org/10.25208/vdv569.

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The authors describe a clinical observation of quite a rare neoplasm such as back skin leiomyoma in a female patient aged 56. They describe the clinical picture, differential diagnostics and pathohistological picture of the disease. The pain syndrome was arrested due to the treatment with calcium channel blockers in a combination with alpha-blockers.

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Kookasamkij, Peeracha, Natnicha Klabsuwan, and Rungnapa Tungsa. "Efficacy of Orthosiphon aristatus (Cat’s Whiskers) and an alpha-blocker for stone expulsion in patients with urinary tract calculi undergoing extra corporal shockwave lithotripsy." Insight Urology 45, no. 2 (2024): 103–9. https://doi.org/10.52786/isu.a.92.

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Objective: To evaluate the efficacy of a herbal treatment, Orthosiphon aristatus (Cat’s Whiskers) and alpha blockers with regard to stone free and treatment success rates in patients with urinary tract calculi undergoing extra corporal shockwave lithotripsy (ESWL). Materials and Methods: Data pertinent to 84 patients who underwent ESWL for treatment of KUB stones were prospectively analyzed. Patients were randomized into two groups: Group 1: patients received the medicinal herb Orthosiphon arista- tus post ESWL and Group 2: patients received an alpha-blocker (Doxazocin 2 mg) post ESWL. Both gr

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Pourkhalili, Nazila, Shirin Pournourmohammadi, Fatemeh Rahimi, et al. "Comparative Effects of Calcium Channel Blockers, Autonomic Nervous System Blockers, and Free Radical Scavengers On Diazinon-Induced Hyposecretion Of Insulin From Isolated Islets of Langerhans in Rats." Archives of Industrial Hygiene and Toxicology 60, no. 2 (2009): 157–64. http://dx.doi.org/10.2478/10004-1254-60-2009-1917.

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Comparative Effects of Calcium Channel Blockers, Autonomic Nervous System Blockers, and Free Radical Scavengers On Diazinon-Induced Hyposecretion Of Insulin From Isolated Islets of Langerhans in RatsHyperglycaemia has been observed with exposure to organophosphate insecticides. This study was designed to compare the effects of calcium channel blockers, alpha-adrenergic, beta-adrenergic, and muscarinic receptor blockers, and of free radical scavengers on insulin secretion from diazinon-treated islets of Langerhans isolated from the pancreas of rats using standard collagenase digestion, separati

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Eraky, Akram M., Yashwanth Yerramalla, Adnan Khan, et al. "Beta-Blockers as an Immunologic and Autonomic Manipulator in Critically Ill Patients: A Review of the Recent Literature." International Journal of Molecular Sciences 25, no. 15 (2024): 8058. http://dx.doi.org/10.3390/ijms25158058.

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The autonomic nervous system plays a key role in maintaining body hemostasis through both the sympathetic and parasympathetic nervous systems. Sympathetic overstimulation as a reflex to multiple pathologies, such as septic shock, brain injury, cardiogenic shock, and cardiac arrest, could be harmful and lead to autonomic and immunologic dysfunction. The continuous stimulation of the beta receptors on immune cells has an inhibitory effect on these cells and may lead to immunologic dysfunction through enhancing the production of anti-inflammatory cytokines, such as interleukin-10 (IL-10), and inh

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Castinetti, Frederic, Jean-Baptiste De Freminville, Carole Guerin, Erika Cornu, Gabrielle Sarlon, and Laurence Amar. "Controversies about the systematic preoperative pharmacological treatment before pheochromocytoma or paraganglioma surgery." European Journal of Endocrinology 186, no. 5 (2022): D17—D24. http://dx.doi.org/10.1530/eje-21-0692.

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The question of systematic use of a pharmacological treatment before surgery in patients diagnosed with pheochromocytoma and paraganglioma (PPGL) remains highly controversial. While recent guidelines suggest that this should be used in all patients, some experienced teams consider it unnecessary in some cases, provided the surgery is performed in a dedicated center that has expert endocrinologists, cardiologists, surgeons, and anesthetists. This controversy is aimed at shedding light on the potential benefits and risks of such a treatment, focusing specifically on alpha blockers which are cons

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Wang, Wei-Hung, Yi-Ting Hung, Chi Luo, et al. "Continuation of Selective Alpha Blocker After Transurethral Resection of the Prostate Is Associated with a Decreased Risk of Hip Fractures in Elderly Patients Diagnosed with Benign Prostate Hyperplasia." Life 15, no. 4 (2025): 641. https://doi.org/10.3390/life15040641.

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Hip fractures significantly affect mortality and quality of life in the elderly population. Although alpha-blockers are commonly prescribed for lower urinary tract symptoms after transurethral resection of the prostate (TURP), their long-term safety regarding fracture risk remains controversial. This study aimed to investigate whether long-term alpha-blocker use after TURP affects the risk of hip fractures requiring surgery in elderly men. This study included 6853 male patients aged ≥50 years who underwent TURP between 2000 and 2018. The alpha-blocker group (n = 1371) included patients who con

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Sahu, Pratap Kumar, Mahesh Kumar Dash, and Audifax Kpeno. "Phenylephrine causes anuria in a patient with benign prostatic hyperplasia." International Journal of Research in Medical Sciences 13, no. 1 (2024): 427–29. https://doi.org/10.18203/2320-6012.ijrms20244150.

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Phenylephrine is classified as an alpha-adrenergic agonist and used as a nasal decongestant. Benign prostatic hyperplasia (BPH) is a common progressive disease in males over the age of 40, leading to urethral constriction. Alpha-1A (α1A) receptor blockers such as Silodosin are commonly prescribed to manage BPH symptoms. They relax the smooth muscle around the bladder exit, in the lower urinary tract and prostate gland to facilitate the passage of urine in BPH. However, when combined with alpha-adrenergic agonists such as Phenylephrine, this mechanism may be disrupted. This case report highligh

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Wilson, Marcus D., and C. Wayne Weart. "Hypertension: Are Beta-Blockers and Diuretics Appropriate First-Line Therapies?" Annals of Pharmacotherapy 28, no. 5 (1994): 617–25. http://dx.doi.org/10.1177/106002809402800512.

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OBJECTIVE: To review the existing data on the use of diuretics or beta-blockers as first-line therapy for the treatment of mild to moderate hypertension, and to examine the issues surrounding the impact of these classes as well as the angiotensin-converting enzyme (ACE) inhibitors, calcium-channel blockers (CCBs), alphablockers, and alpha-beta-blockers on cardiovascular risk factors and cardiovascular morbidity and mortality. DATA SOURCES: A MEDLINE search of applicable articles on antihypertensive therapies and their impact on morbidity and mortality. In addition, a MEDLINE search of relevant

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SUZUKAWA, Michio. "Effects of Alpha 1-Adrenoceptor Blockers on Lipid Metabolism." Journal of Japan Atherosclerosis Society 20, no. 8-9 (1992): 681–90. http://dx.doi.org/10.5551/jat1973.20.8-9_681.

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Andersson, K. E., and M. G. Wyllie. "Ejaculatory dysfunction: why all alpha-blockers are not equal." BJU International 92, no. 9 (2003): 876–77. http://dx.doi.org/10.1111/j.1464-410x.2003.04590.x.

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