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Artykuły w czasopismach na temat "And wound-healing properties"
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Hillman, Prima F., Chaeyoung Lee, and Sang-Jip Nam. "Microbial Natural Products with Wound-Healing Properties." Processes 11, no. 1 (2022): 30. http://dx.doi.org/10.3390/pr11010030.
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Wound healing continues to pose a challenge in clinical settings. Moreover, wound management must be performed properly and efficiently. Acute wound healing involves multiple cell divisions, a new extracellular matrix, and the process of formation, such as growth factors and cytokines, which are released at the site of the wound to regulate the process. Any changes that disrupt the healing process could cause tissue damage and prolong the healing process. Various factors, such as microbial infection, oxidation, and inflammation, can delay wound healing. In order to counter these problems, utilizing natural products with wound-healing effects has been reported to promote this process. Several natural products have been associated with wound healing, most of which are from medicinal plants. However, secondary microbial metabolites have not been extensively studied for their wound-healing properties. Further, investigations on the wound-healing control of natural microbial products are required due to a lack of studies. This review discussed the in vivo and in vitro research on the wound healing activities of natural microbial products, which may assist in the development of better wound treatments in the future.
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Green, A. E. "Wound healing properties of honey." British Journal of Surgery 75, no. 12 (1988): 1278. http://dx.doi.org/10.1002/bjs.1800751236.
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Choudhary, Vikram, and H. G. Shivakumar. "A REVIEW ON CURCUMIN: WOUND HEALING PROPERTIES AND BIOMARKERS OF WOUND HEALING." International Research Journal Of Pharmacy 9, no. 9 (2018): 1–5. http://dx.doi.org/10.7897/2230-8407.099179.
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Ibrahim, Nurul, Sok Wong, Isa Mohamed, et al. "Wound Healing Properties of Selected Natural Products." International Journal of Environmental Research and Public Health 15, no. 11 (2018): 2360. http://dx.doi.org/10.3390/ijerph15112360.
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Wound healing is a complex process of recovering the forms and functions of injured tissues. The process is tightly regulated by multiple growth factors and cytokines released at the wound site. Any alterations that disrupt the healing processes would worsen the tissue damage and prolong repair process. Various conditions may contribute to impaired wound healing, including infections, underlying diseases and medications. Numerous studies on the potential of natural products with anti-inflammatory, antioxidant, antibacterial and pro-collagen synthesis properties as wound healing agents have been performed. Their medicinal properties can be contributed by the content of bioactive phytochemical constituents such as alkaloids, essential oils, flavonoids, tannins, saponins, and phenolic compounds in the natural products. This review highlights the in vitro, in vivo and clinical studies on wound healing promotions by the selected natural products and the mechanisms involved.
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Li, Rongkai, Qinbing Qi, Chunhua Wang, Guige Hou, and Chengbo Li. "Self-Healing Hydrogels Fabricated by Introducing Antibacterial Long-Chain Alkyl Quaternary Ammonium Salt into Marine-Derived Polysaccharides for Wound Healing." Polymers 15, no. 6 (2023): 1467. http://dx.doi.org/10.3390/polym15061467.
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The development of hydrogels as wound dressings has gained considerable attention due to their promising ability to promote wound healing. However, in many cases of clinical relevance, repeated bacterial infection, which might obstruct wound healing, usually occurs due to the lack of antibacterial properties of these hydrogels. In this study, we fabricated a new class of self-healing hydrogel with enhanced antibacterial properties based on dodecyl quaternary ammonium salt (Q12)-modified carboxymethyl chitosan (Q12-CMC), aldehyde group- modified sodium alginate (ASA), Fe3+ via Schiff bases and coordination bonds (QAF hydrogels). The dynamic Schiff bases and coordination interactions conferred excellent self-healing abilities to the hydrogels, while the incorporation of dodecyl quaternary ammonium salt gave the hydrogels superior antibacterial properties. Additionally, the hydrogels displayed ideal hemocompatibility and cytocompatibility, crucial for wound healing. Our full-thickness skin wound studies demonstrated that QAF hydrogels could result in rapid wound healing with reduced inflammatory response, increased collagen disposition and improved vascularization. We anticipate that the proposed hydrogels, possessing both antibacterial and self-healing properties, will emerge as a highly desirable material for skin wound repair.
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Dodi, Gianina, Rosina E. Sabau, Bianca E. B. Crețu, and Ioannis Gardikiotis. "Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing." Pharmaceutics 15, no. 8 (2023): 2152. http://dx.doi.org/10.3390/pharmaceutics15082152.
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It is acknowledged that the presence of antioxidants boosts the wound-healing process. Many biopolymers have been explored over the years for their antioxidant potential in wound healing, but limited research has been performed on gum structures and their derivatives. This review aims to evaluate whether the antioxidant properties of gellan and guar gums and wound healing co-exist. PubMed was the primary platform used to explore published reports on the antioxidant wound-healing interconnection, wound dressings based on gellan and guar gum, as well as the latest review papers on guar gum. The literature search disclosed that some wound-healing supports based on gellan gum hold considerable antioxidant properties, as evident from the results obtained using different antioxidant assays. It has emerged that the antioxidant properties of guar gum are overlooked in the wound-healing field, in most cases, even if this feature improves the healing outcome. This review paper is the first that examines guar gum vehicles throughout the wound-healing process. Further research is needed to design and evaluate customized wound dressings that can scavenge excess reactive oxygen species, especially in clinical practice.
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Hong, Zhiwu, Lei Wu, Zherui Zhang, et al. "Self-Healing Supramolecular Hydrogels with Antibacterial Abilities for Wound Healing." Journal of Healthcare Engineering 2023 (February 9, 2023): 1–10. http://dx.doi.org/10.1155/2023/7109766.
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Wound healing due to skin defects is a growing clinical concern. Especially when infection occurs, it not only leads to impair healing of the wound but even leads to the occurrence of death. In this study, a self-healing supramolecular hydrogel with antibacterial abilities was developed for wound healing. The supramolecular hydrogels inherited excellent self-healing and mechanical properties are produced by the polymerization of N-acryloyl glycinamide monomers which carries a lot of amides. In addition, excellent antibacterial properties are obtained by integrating silver nanoparticles (Ag NPs) into the hydrogels. The resultant hydrogel has a demonstrated ability in superior mechanical properties, including stretchability and self-healing. Also, the good biocompatibility and antibacterial ability have been proven in hydrogels. Besides, the prepared hydrogels were employed as wound dressings to treat skin wounds of animals. It was found that the hydrogels could significantly promote wound repair, including relieving inflammation, promoting collagen deposition, and enhancing angiogenesis. Therefore, such self-healing supramolecular hydrogels with composite functional nanomaterials are expected to be used as new wound dressings in the field of healthcare.
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Brown, Stuart J., Farhana Surti, Paul Sibbons, and Lilian Hook. "Wound healing properties of a fibrin-based dermal replacement scaffold." Biomedical Physics & Engineering Express 8, no. 1 (2021): 015025. http://dx.doi.org/10.1088/2057-1976/ac4176.
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Abstract When serious cutaneous injury occurs, the innate wound healing process attempts to restore the skin’s appearance and function. Wound healing outcome is affected by factors such as contraction, revascularisation, regeneration versus fibrosis and re-epithelialisation and is also strongly influenced by the pattern and extent of damage to the dermal layer. Dermal replacement scaffolds have been designed to substitute for lost tissue, provide a structure to promote dermal regeneration, and aid skin grafting, resulting in a superior healing outcome. In this study the wound healing properties of a novel fibrin-alginate dermal scaffold were assessed in the porcine wound healing model and also compared to two widely used dermal scaffolds and grafting alone. The fibrin-alginate scaffold, unlike the other scaffolds tested, is not used in combination with an overlying skin graft. Fibrin scaffold treated wounds showed increased, sustained superficial blood flow and reduced contraction during early healing while showing comparable wound closure, re-epithelialisation and final wound outcome to other treatments. The increase in early wound vascularisation coupled with a decrease in contraction and no requirement for a skin graft suggest that the fibrin-based scaffold could provide an effective, distinctive treatment option to improve healing outcomes in human patients.
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Alven, Sibusiso, Vuyolwethu Khwaza, Opeoluwa O. Oyedeji, and Blessing A. Aderibigbe. "Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds." Pharmaceutics 13, no. 7 (2021): 961. http://dx.doi.org/10.3390/pharmaceutics13070961.
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The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.
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Firda, Rahmania, and Fawzy Ahmad. "Efficacy of Honey-Based Wound Dressing Versus Hydrogel-Based Wound Dressing in Wound Healing Process: A Literature Review." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 04, no. 05 (2024): 812–17. https://doi.org/10.5281/zenodo.11125857.
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<strong>Introduction:</strong> Wound dressing is a fundamental aspect of modern healthcare, encompassing a diverse range of materials and techniques aimed at optimizing the healing process while safeguarding against infection and further injury. By understanding the specific benefits of different types of wound dressings, healthcare professionals can optimize the healing process and improve patient outcomes <strong>Methods:</strong> This literature review was compiled using information from various open access online databases. Data were collected and analyzed. <strong>Results and Discussions: </strong>Honey dressing demonstrates superior efficacy compared to hydrogel dressing in wound management. Its multifaceted properties, such as potent antimicrobial activity, tissue regeneration promotion, and anti-inflammatory effects, render it a superior option for wound healing throughout all stages. Additionally, honey is more cost-effective than hydrogel and more easily accessible. <strong>Conclusion:</strong> The efficacy of honey dressing surpasses that of hydrogel dressing in wound management. Honey's multifaceted properties, including its potent antimicrobial activity, ability to promote tissue regeneration, and anti-inflammatory effects, make it a superior choice for wound healing across all phases.
Rozprawy doktorskie na temat "And wound-healing properties"
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Hong, Sung-Ha. "Development of a wound dressing for detection of bacteria with wound healing properties." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619143.
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There has been a significant increase in children’s burns in the past several years and figures indicate that children suffer more burns compared to any other age groups. The main concern following a burn is the possibility of infections. The aim of this project is to construct a unique wound dressing, which enhances healing and stimulates wound closure by incorporation of collagen, as well as signalling the presence of pathogenic bacteria on colonisation. The process of signalling bacterial colonisation was achieved by incorporation of a phospholipid based nanocapsule, with a colourimetric response and a mechanism for release of a dye. This research invested into finding the optimum phospholipid composition to obtain a stable and sensitive system. The signalling device uses the biomimetic aspect of vesicles to signal the presence of pathogenic bacteria via the effect of secreted toxins on the sensor interface. The modified phospholipid based sensors were immobilised into gel matrices and further developed to produce prototype dressings. The healing enhancing property was achieved by a thin layer of collagen coating. This work presents the results obtained from the initial modification process of the sensor, to incorporation of the vesicles into gel matrices through to development of First and Second Generation Prototype dressings. Verification of stability and sensitivity of the vesicles was carried out following each stage of development, using clinically isolated strains of pathogenic bacteria. Initial cytotoxicity and verification of the wound healing property was achieved by in vitro cell assays.
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Zhai, Zili. "Immunomodulatory, anti-inflammatory and wound healing properties of Echinacea species." [Ames, Iowa : Iowa State University], 2008.
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Hetrick, Evan M. Schoenfisch Mark H. "Antimicrobial and wound healing properties of nitric oxidereleasing xerogels and silica nanoparticles." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1928.
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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry Analytical Chemistry." Discipline: Chemistry; Department/School: Chemistry.
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Deng, X., B. Huang, Q. Wang, et al. "A mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healing." ACS PUBLICATION, 2021. http://hdl.handle.net/10454/18387.
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Yes<br>Antibacterial hydrogels have been intensively
studied due to their wide practical potential in wound healing.
However, developing an antibacterial hydrogel that is able to
integrate with exceptional mechanical properties, cell affinity, and
adhesiveness will remain a major challenge. Herein, a novel
hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate−
dopamine (Alg-DA) chains to cross-link with the copolymer chains
of acrylamide and acrylic acid (PAM) via triple dynamic
noncovalent interactions, including coordination, electrostatic
interaction, and hydrogen bonding. The cationized nanofibrillated
cellulose (CATNFC), which was synthesized by the grafting of
long-chain quaternary ammonium salts onto nanofibrillated
cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine
(Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent
fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the
outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell
affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both
preventing bacterial infection and promoting tissue regeneration during wound healing processes.<br>This work was supported by the National Natural Science Foundation of China (32070826 and 51861165203), the Chinese Postdoctoral Science Foundation (2019M650239, 2020T130762), the Sichuan Science and Technology Program (2019YJ0125), the State Key Laboratory of Polymer Materials Engineering (sklpme2019-2-19), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2018jcyjAX0807), Chongqing Medical Joint Research Project of Chongqing Science and Technology Committee & Health Agency (2020GDRC017), and the RCUK China-UK Science Bridges Program through the Medical Research Council, and the Fundamental Research Funds for the Central Universities.<br>The full-text of this article will be released for public view at the end of the publisher embargo on 12 Feb 2022..
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Montalbano, Giuseppina. "Evaluation of the antimicrobial, anti-inflammatory, regenerative and wound healing properties of the bracket fungus ganoderma lucidum." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/116592/2/Giuseppina_Montalbano_Thesis.pdf.
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Ganoderma lucidum, a saprophytic bracket fungus native to Queensland’s tropical rainforests, was traditionally used to heal wounds and ensure smooth tissue regeneration. Its pharmaceutical formulations such as teas, decoctions and capsules are claimed to cover a range of diseases, however, the alleged pharmacological properties of G. lucidum have not yet been fully scientifically validated. This study has demonstrated G. lucidum’s in vitro role as a wound healing agent as a result of its concomitant and/or predominant antibacterial, anti-inflammatory and regenerative properties. This research will contribute to a development of a novel therapeutic for the treatment of chronic non-healing wounds.
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MAGNAVACCA, ANDREA. "BRAZILIAN PROPOLIS: A MULTIFACETED NATURAL PRODUCT WITH HEALING PROPERTIES - A COMPREHENSIVE STUDY ON THE ABILITY TO IMPROVE CUTANEOUS WOUND HEALING THROUGH HIF-1 MODULATION." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/946269.
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La guarigione delle ferite cutanee consiste in un processo dinamico e multifasico, comprendente le quattro fasi parzialmente sovrapposte di emostasi, infiammazione, proliferazione e rimodellamento, che si innesca in risposta ad un danno e richiede l’intervento orchestrato di elementi cellulari e non per ristabilire l’integrità tissutale e l’omeostasi locale. L’esito finale della guarigione è di norma la riparazione, una forma di incompleta rigenerazione che implica fibrosi e la formazione di cicatrici la cui estensione è proporzionale alla durata e intensità della fase infiammatoria. Una precoce condizione di lieve ipossia è in grado di stimolare la sopravvivenza cellulare. Infatti, oltre ad essere i principali responsabili delle risposte cellulari in scarsità di ossigeno, i fattori indotti da ipossia (HIF) svolgono un ruolo preminente nell’espressione di numerosi geni coinvolti nel processo di guarigione. Recenti scoperte suggeriscono inoltre che la stabilizzazione farmacologica di HIF-1α, indipendentemente dalla presenza di ipossia, possa evocare un fenotipo rigenerativo, attribuendo a HIF un ruolo nella rigenerazione tissutale. Prodotti di origine naturale in grado svolgere molteplici attività sul microambiente della ferita, modulando la via di segnalazione di HIF-1 e al contempo contrastando i deleteri effetti dell’infiammazione, sono candidati promettenti per migliorare il riparo, e possibilmente la rigenerazione, delle ferite cutanee. La propoli è un prodotto resinoso, ricco in sostanze polifenoliche, elaborato dalle api a partire da essudati vegetali e tradizionalmente impiegato per la guarigione delle ferite grazie alle note proprietà antimicrobiche, antiossidanti, antinfiammatorie e immunomodulatorie. Le attività biologiche dipendono dalla composizione chimica e variano a seconda di origine geografica, condizioni ambientali e fonti botaniche da cui le api bottinano le resine. Numerosi chemotipi di propoli sono stati classificati, incluse numerose varietà brasiliane. Lo scopo di questo studio è la valutazione in vitro delle attività biologiche delle propoli brasiliane verde e rossa in cheratinociti (HaCaT) e fibroblasti dermici (HDF) umani, esplorando la capacità di modulare la via di segnalazione di HIF-1 per corroborarne l’applicazione come innovativi agenti di guarigione. La preliminare caratterizzazione chimica condotta mediante HPLC-UV, GC-MS e HPLC-HRMS ha determinato la presenza di artepillina C e drupanina in propoli verde, e vestitolo/neovestitolo e medicarpina in propoli rossa, come componenti principali. L’abilità delle propoli di inibire la trascrizione guidata da NF-κB è stata valutata a seguito di stimolazione con TNF-α o IL-1β, mostrando una maggiore attività della propoli rossa (IC50 < 10 μg/mL in HaCaT, IC50 = 23.6 μg/mL in HDF), prominente anche sulla secrezione di IL-8 indotta da TNF-α (IC50 = 11.89 μg/mL in HaCaT, IC50 = 5.89 μg/mL in HDF). La propoli rossa si è dimostrata in grado di indurre l’espressione del gene IL6, codificante una citochina pleiotropica con funzioni risolventi, e la secrezione di IL-6 sotto stimolo pro-infiammatorio. L’investigazione della stabilizzazione e della traslocazione nucleare di HIF-1α suggerisce l’attività di entrambe le propoli in cheratinociti HaCaT, mentre solo la propoli rossa risulta attiva in fibroblasti HDF. Tali risultati sono stati confermati mediante immunocitochimica, western blot e qPCR del gene target di HIF-1 VEGFA. Infine, è stato condotto un frazionamento bioguidato per meglio definire le entità chimiche responsabili dell’attività biologica. A seguito dell’iniziale frazionamento mediante partizione fra solventi immiscibili, l’attività biologica è stata determinata in un saggio reporter per HIF-1. Le frazioni attive sono state ulteriormente subfrazionate mediante cromatografia su colonna di Sephadex LH-20, permettendo la qualificazione delle molecole ipoteticamente responsabili della stabilizzazione di HIF-1. Complessivamente, i risultati di questo studio contribuiscono a delucidare i meccanismi molecolari alla base della promettente attività delle propoli brasiliane nella guarigione delle ferite, gettando luce sul possibile utilizzo di questi prodotti naturali nella rigenerazione cutanea.<br>Cutaneous wound healing is a dynamic multi-step process, encompassing the four cascading, partially overlapping, phases of haemostasis, inflammation, proliferation, and remodelling, that occurs in response to injuries and requires a well-orchestrated intervention of cellular and non-cellular elements to regain tissue integrity and restore local homeostasis. The ultimate outcome of skin wound healing is most commonly repair, a form of incomplete regeneration implying fibrosis and the formation of scars proportional to the duration and severity of inflammation. An early condition of mild hypoxia can trigger cell survival. Apart from being master regulators of cellular responses under hypoxia, hypoxia-inducible factors (HIFs) play a key role in upregulating the expression of several genes that enhance wound healing. Recent evidence suggests that also the non-hypoxic pharmacological stabilisation of HIF-1α can evoke a regenerative phenotype, claiming a role for HIFs in tissue regeneration. Natural products able to elicit multifaceted activities on the wound microenvironment, modulating the HIF-1 pathway while counteracting the deleterious drawbacks of inflammation, are promising candidates to enhance repair, and possibly regeneration, of skin injuries. Propolis is a resinous, polyphenol-rich, product elaborated by honeybees from plant exudates, and traditionally used for wound healing due to its renowned anti-microbial, antioxidant, anti-inflammatory, and immunomodulatory properties. The biological activities depend on the chemical composition and vary according to geographic origin, environmental conditions, and botanical sources from which bees gather the resins. Numerous chemotypes of propolis have been classified, including several Brazilian varieties. The aim of this study was a comprehensive in vitro evaluation of green and red Brazilian propolis biological activities on human keratinocytes (HaCaT) and dermal fibroblasts (HDF), exploring the ability to modulate the HIF-1 pathway to substantiate their application as innovative healing agents. The preliminary chemical characterisation conducted through HPLC-UV, GC-MS, and HPLC-HRMS determined the presence of artepillin C and drupanin in green propolis, and vestitol/neovestitol and medicarpin in red propolis as major components. The ability of propolis to impair NF-κB-driven transcription was evaluated upon TNF-α or IL-1β stimulation, showing a greater activity of red propolis (IC50s < 10 μg/mL in HaCaT cells, IC50 = 23.6 μg/mL in HDF cells), prominent also on TNF-α-induced IL-8 secretion (IC50 = 11.89 μg/mL in HaCaT cells, IC50 = 5.89 μg/mL in HDF cells). On the other hand, red propolis proved able to induce the overexpression of IL6 gene, encoding a pleiotropic cytokine with pro-resolving functions, and enhance IL-6 release under pro-inflammatory stimulation. The investigation of HIF-1α stabilisation and nuclear translocation suggested the activity of both propolis in HaCaT cells, while only red propolis was active in HDF cells. These results have been confirmed through immunocytochemistry, western blot, and qPCR of the HIF-1 target gene VEGFA. Finally, a bioguided fractionation has been performed to better clarify the chemical species responsible for the biological activities. Following an initial fractionation by partitioning between immiscible solvents, the biological activity was screened in a HIF-1 reporter assay. Active fractions were further subfractioned by Sephadex LH-20 column chromatography, enabling to the qualification of the putative molecules responsible for HIF-1 stabilisation. Taken together, the results of this study contribute to elucidate the molecular mechanisms behind the promising activity of Brazilian propolis in wound healing, shedding light on the possible exploitation of these natural products in skin regeneration.
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Pringle, Nadine Alex. "Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/11992.
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Diabetic wounds frequently undergo impaired and prolonged wound healing due to a multitude of factors including hypoxia, impaired angiogenesis, hyperglycaemia, formation of ROS and AGEs, and infection - all of which may lead to cellular dysfunction. To date, however, treatment options for individuals suffering from impaired diabetic wound healing are limited, non-specific, and generally unsuccessful. The search for new and effective treatment strategies is severely hampered by the availability of adequately characterized screening models which comprehensively mimic the complexity of the diabetic wound healing process. In order to explore natural products as potential therapeutics to treat diabetic wounds and to encourage more research on this topic, this study sought out to develop and characterize a more convenient and cost effective in vitro screening assay which mimics the effects of protein glycation on the healing process of diabetic wounds. As proof of principal, this model was subsequently used to screen the potential of five wild mushroom species (P. tinctorius, R. capensis, B. badius, P. ostreatus and G. lucidum) as suitable diabetic wound healing therapies. The glycated gelatin model developed during this study was found to suitably mimic the diabetic state as it successfully simulated the major cellular dysfunctions in macrophages (NO production, phagocytosis, macrophage polarization, NF-ĸB translocation and COX-2 expression) and fibroblasts (proliferation and migration) documented during diabetic wound healing. Together these findings provide confidence that the model may serve as a valuable tool to study the poorly understood mechanisms which characterize cellular dysfunction in response to AGE accumulation and also to aid the identification of novel therapeutic agents to treat this pathology. Screening a number of mushroom extracts revealed that the ethanol extracts of R. capensis and P. ostreatus had the greatest potential for attenuating chronic inflammation due to their ability to promote macrophage phagocytosis, increased M2 activation (R. capensis) and decreased M1 activation (P. ostreatus) as well as reduced COX-2 expression while the water extract of G. lucidum proved to be the most promising candidate for stimulating fibroplasia as it was the most successful at promoting both fibroblast proliferation and migration. Different mushroom species were thus shown to promote different stages of the wound healing process providing sufficient evidence to support further studies related to the use of macrofungi as therapeutic agents in the search for more cost-effective and efficient treatment strategies for impaired diabetic wound healing.
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Sathananthan, Saranya. "Modulating fibrin matrix properties via fibrin knob peptide functionalized microgels." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44905.
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Fibrin is the body's natural provisional matrix activated in response to vascular injury in which noncovalent knob:hole interactions between fibrin monomers lead to the assembly of fibrin for clot formation. In this study we aimed to exploit fibrin knob:hole affinity interactions with swelling, space filling microgels for the development of a potential bio-synthetic hybrid polymer system with hemostatic properties. Previous work has explored the inherent binding interactions of various fibrin knobs and their complementary polymerization holes, which have led to the development of fibrin knob peptide mimic (GPRPFPAC) with enhanced binding affinity for fibrin(ogen) holes. By coupling this enhanced fibrinogen binding peptide with a pNIPAm microgel system capable of being dynamically tuned and self-assembled, we hypothesized the specific and rapidly triggered formation of a bulk hydrogel in a wound environment (i.e. in the presence of fibrinogen). We found that at the peptide ligand density and concentrations of microgels used, that a rapid formation of a gel did not occur in the presence of fibrinogen alone. However with fibrinogen and thrombin, we found that fibrin network polymerization, structure, and viscoelastic properties were greatly altered in the presence of knob peptide-conjugated microgels.
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Дьорка, Олена Ігорівна. "Розробка ранозагоювального препарату на основі солодки голої екстракту сухого". Магістерська робота, Київський національний університет технологій та дизайну, 2021. https://er.knutd.edu.ua/handle/123456789/19273.
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Дипломну магістерську роботу присвячено розробці препарату рослинного походження для лікування ран на основі солодки голої екстракту сухого. Проведено теоретичний аналіз застосування лікарських препаратів на основі екстракту солодки голої та їх позиціонування на сучасному фармацевтичному ринку. Наведено аналіз фітохімічного складу та механізми фармакологічної дії біологічно активних сполук екстракту солодки голої, а також визначено перспективи зовнішнього застосування для загоєння ран у вигляді м’якої лікарської форми. Обгрунтовано склад і технологію гелю з екстрактом солодки голої. Шляхом трьохфакторного дисперсійного аналізу підібрані найбільш перспективні модифіковані фармацевтичні композциї. Після проведення мікроскопічного аналізу однорідності гелевої системи відібраних чотирьох зразків експериментальних модифікованих композицій гелів солодки голої встановлено однорідність дисперсних систем та вивчені їх реологічні властивості. Обгрунтовано стадії технологічного процесу одержання гелю з солодки голої екстрактом в умовах фармацевтичного виробництва.<br>The master's thesis is devoted to the development of a herbal preparation for the treatment of wounds based on dry extract of licorice bare. A theoretical analysis of the use of drugs based on licorice extract and their positioning in the modern pharmaceutical market has been carried out. An analysis of the phytochemical composition and mechanisms of the pharmacological action of biologically active compounds of the licorice extract is presented, as well as the prospects for external use for wound healing in the form of a soft dosage form. The composition and technology of the gel with licorice extract are substantiated. The most promising modified pharmaceutical compositions were selected by means of a three-factor analysis of variance. After microscopic analysis of the homogeneity of the gel system, four samples were taken. For these experimental modified compositions of licorice gels, the homogeneity of dispersed systems was established and their rheological properties were studied. The stages of the technological process of obtaining a gel from an extract of licorice under the conditions of pharmaceutical production are substantiated.
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Comune, Michela. "Wound healing and pro-angiogenic properties of LL37-conjugated nanoparticles." Doctoral thesis, 2016. http://hdl.handle.net/10316/30202.
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Tese de doutoramento em Biociências na especialidade de Biotecnologia, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Problemas de cicatrização de feridas e suas complicações médicas continuam a ser um dos problemas de saúde mais prevalentes e economicamente onerosos do mundo. Nos Estados Unidos, as feridas crónicas afectam 6.5 milhões de pacientes. Mais de 25 bilhões de dólares são gastos anualmente em tratamento de feridas crónicas e a despesa irá crescer rapidamente devido ao aumento dos custos de saúde, o envelhecimento da população e um aumento acentuado na incidência de diabetes e obesidade em todo o mundo. Dados recentes indicam que 11.7% da população Portuguesa é diabética. Uma das complicações mais graves e debilitantes da diabetes é o desenvolvimento de feridas crónicas e não cicatrizantes. Nos últimos anos, tem havido esforços para se desenvolver terapias avançadas para a cicatrização de feridas crónicas, incluindo o uso tópico de factores de crescimentos ou terapias celulares. Infelizmente, em muitos casos, a eficácia terapêutica é baixa, as terapias são caras, requerem aplicação clínica e não possuem actividade antimicrobiana. Portanto, é imperativo o desenvolvimento de novas terapêuticas para responder a esta necessidade clínica. Os péptidos antimicrobianos (AMPs) sintetizados na pele podem constituir futuras terapias já que são moléculas que formam uma barreira à infecção e alguns deles são muito importantes para a regeneração da pele (4). O péptido LL37 é o AMP mais importante na pele, actuando como primeira linha de defesa contra bactérias, vírus, fungos e desempenha um papel importante na imunomodulação, angiogénese e cicatrização de feridas. Recentemente, foram publicados os resultados de um ensaio clínico fase I / II com o péptido LL37 que demonstram a sua eficácia terapêutica em feridas crónicas; no entanto, foram necessárias múltiplas administrações tópicas. O objectivo principal desta tese foi desenvolver uma formulação de nanopartículas conjugadas com LL37 de forma a possuir maior actividade de cicatrização da pele que o péptido livre (não imobilizado). A formulação de nanopartículas foi preparada por uma nova metodologia na qual foi utilizado o péptido LL37 com um terminal tiol, actuando o péptido como agente de revestimento durante a formação da nanopartícula. Esta formulação tem um núcleo de ouro (Au) e um escudo formado pelo péptido catiónico LL37. Durante esta tese seleccionámos nanopartículas de ouro porque é relativamente fácil a imobilização de altas concentrações de LL37 por unidade de superfície, a modificação das suas propriedades (incluindo tamanho, carga e morfologia), e pelo facto destas nanopartículas terem sido utilizadas na prática clínica há muitos anos. Estas nanopartículas possuem um tamanho controlado (21 nm), baixa polidispersão, um potencial zeta positivo (15 mV), alta densidade de LL37 (250 μg de péptido por mg de nanopartícula) e alta estabilidade em soluções aquosas e meios de cultura celular. As nanopartículas mostraram actividade antimicrobiana contra E. coli e elevada actividade biológica contra células de mamíferos, ou seja, actividade pró-angiogénica em células endoteliais e actividade pró-migratória em queratinócitos. Surpreendentemente, as nanopartículas conjugadas com LL37 possuem menor citotoxicidade que o péptido LL37 livre. Os nossos resultados mostram ainda que as nanopartículas são internalizadas pelos queratinócitos e células endoteliais, e no caso de queratinócitos, o processo de internalização é mediado principalmente pelo receptor scavenger. As nanopartículas internalizadas tendem a se acumular no compartimento endolisomal dos queratinócitos, mas conseguem escapar o compartimento endolisomal em células endoteliais. Em ambos os modelos celulares, as nanopartículas induzem a transactivação do EGFR. No caso dos queratinócitos, o processo é iniciado pela activação de receptores P2X que levam a uma prolongada fosforilação de EGFR e de ERK. Isto leva a que os queratinócitos possuam maiores propriedades migratórias. Os resultados in vivo mostram que nanopartículas conjugadas com LL37 têm melhores propriedades cicatrizantes de feridas comparativamente ao péptido livre. No caso de células endoteliais, o péptido LL37, mas não as nanopartículas conjugadas com LL37, levam à activação do receptor FPRL-1, à acumulação de cálcio intracelular e à secreção de VEGF165. No entanto, tanto o péptido LL37 como as nanopartículas conjugadas com LL37 têm elevada actividade pró-angiogénica, demonstrado num ensaio de membrana corioalantóica (CAM). É provável que a actividade pró-angiogénica das nanopartículas conjugadas com LL37 seja mediada pela transactivação de EGFR, mas mais estudos são necessários para responder a esta questão. Os resultados apresentados nesta tese são um primeiro passo para o desenvolvimento de terapias baseadas em nanomedicina à base de péptidos antimicrobianos. Esta é a primeira terapia que combina propriedades de cicatrização de feridas e actividade antimicrobiana na mesma formulação, é mais barata do que as terapias avançadas actuais, e pode ser administrada uma única vez.
Impaired wound healing and its medical complications remain one of the most
prevalent and economically burdensome healthcare issues in the world. In the
United States alone, chronic wounds affect 6.5 million patients. More than US$25
billion is spent annually on treatment of chronic wounds and the burden is growing
rapidly due to increasing health care costs, an aging population and a sharp rise in
the incidence of diabetes and obesity worldwide. Recent data indicate that 11.7%
of the Portuguese population is diabetic. One of the most serious and debilitating
complications of diabetes is the development of chronic non-healing wounds. In
recent years, there have been efforts to develop new advanced methodologies to
heal chronic wounds including the use of topic growth factors or cell-based thera-
pies. Unfortunately, in many cases, the therapeutic efficacy is low, the therapies are
expensive and require application in a clinical facility, and they have no antimicro-
bial activity. Therefore, development of new therapeutics is absolutely necessary
and important to satisfy the unmet clinical need. Antimicrobial peptides (AMPs)
synthesized in the skin provide a barrier to infection and some of them are very im-
portant for the regeneration of skin. LL37 is the most important AMP in skin, acts as
first line of defense against bacteria, virus, fungi and plays an important role in im-
munomodulation, angiogenesis and wound healing properties. Recently, phase I/II
clinical trials have demonstrated its therapeutic efficacy in chronic wounds; how-
ever, multiple topical administrations were required. The main goal of this the-
sis was to develop a LL37 nanoparticulate formulation with higher wound healing
properties than the free peptide. The nanoparticulate formulation was prepared by
a novel methodology in which thiol-terminated LL37 acts as capping agent during
NP formation. This formulation has a gold (Au) core and a hydrophilic cationic
LL37 peptide shell. We have selected Au NPs because it is relatively easy the immo-
bilization of high concentrations of LL37 per surface area, the modification of their
properties (including size, charge and morphology), and they have been used in the
clinic for many years. LL37-Au NPs have controlled size (21 nm), low polydisper-
sity, positive zeta potential (15 mV), high density of LL37 (250
μ
g of peptide per mg
of NP) and high stability in aqueous solutions and cell culture media. They showed
antimicrobial activity against
E
.
coli
and high biological activity against mammalian
cells, namely pro-angiogenic activity against endothelial cells and pro-migratory
activity against keratinocytes. Remarkably, LL37-Au NPs have lower cytotoxicity
than LL37 peptide. Our results further show that LL37-Au NPs are internalized by
keratinocytes and endothelial cells, and in case of keratinocytes, the internalization process is mostly mediated by scavenger receptors. The internalized LL37-Au NPs
tend to accumulate in the endolysomal compartment in keratinocytes while escape
the endolysomal compartment in endothelial cells. In both cell models, LL37-Au
NPs induce the transactivation of EGFR. In case of keratinocytes, the process is ini-
tiated by the activation of P2X receptors that leads to a long-lasting phosphorylation
of EGFR and ERK. This results in enhanced migratory properties of keratinocytes.
In vivo results show that LL37-Au NPs have superior wound healing properties
than LL37 peptide in a splinted mouse full thickness excisional model. In case of
endothelial cells, LL37 peptide but not LL37-Au NPs activate FPRL-1, intracellular
accumulation of
Ca
2
+
and secretion of VEGF165. Yet, both LL37 and LL37-Au NPs
have high pro-angiogenic activity as demonstrated in a chorioallantoic membrane
(CAM) assay. It is likely that the pro-angiogenic activity of LL37-Au NPs is medi-
ated by the transactivation of EGFR but further studies are needed to address this
issue. The results presented here are an exciting first step toward the development
of antimicrobial peptide-based nanotherapeutics for skin disorders paving the way
for additional studies in more complex animal models. It is the first skin therapy
that combines wound-healing efficacy and antimicrobial activity in the same for-
mulation, it is cheaper than the actual advanced therapies, and may be administered
only one time.
Książki na temat "And wound-healing properties"
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ANNAN, KOFI. Wound Healing Properties of some Indigenous Ghanaian Plants: Antibacterial, antioxidant and fibroblast stimulatory actions of some Ghanaian plants. LAP Lambert Academic Publishing, 2011.
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Al-Ahmed, Amir, ed. Advanced Applications of Micro and Nano Clay. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644901915.
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Due to their characteristic properties, biodegradable nature and non-toxicity, clay-biopolymer based composites have many applications in such advanced fields as drug release, antimicrobial activities, wound healing, tissue engineering, wastewater treatment, food packaging and flame retardant materials. The book reviews fabrication, properties and applications of a great variety of these materials.
Części książek na temat "And wound-healing properties"
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Khan, Elhan, and Iffat Zareen Ahmad. "Cydonia oblonga Mill.: Wound Healing Properties." In Medicinal and Aromatic Plants of the World. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-44914-7_4.
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Tayyib, Nahla A. "Wound Healing and Ficus carica (Fig)." In Fig (Ficus carica): Production, Processing, and Properties. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-16493-4_36.
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Agache, P. G., and P. Humbert. "Noninvasive Assessment of the Physical Properties of the Skin." In Wound Healing and Skin Physiology. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-77882-7_46.
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Islam, Md Sazedul, Md Ashiqur Rahman, Shafiul Hossain, Papia Haque, Md Shahruzzaman, and Mohammed Mizanur Rahman. "Polymer Matrixes Used in Wound Healing Applications." In Nanoscale Engineering of Biomaterials: Properties and Applications. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-3667-7_11.
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St. Denis, Tyler G., Tianhong Dai, Ying-Ying Huang, and Michael R. Hamblin. "Wound-Healing Properties of Chitosan and Its Use in Wound Dressing Biopharmaceuticals." In Chitosan-Based Systems for Biopharmaceuticals. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119962977.ch22.
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Radice, M., L. Cardarelli, R. Cortivo, and G. Abatangelo. "Chemotactic Properties of Human Collagen Breakdown Products in Wound Healing." In Proteolysis in Wound Repair. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61130-8_5.
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Pickart, Loren. "Iamin: A Human Growth Factor with Multiple Wound-Healing Properties." In Biology of Copper Complexes. Humana Press, 1987. http://dx.doi.org/10.1007/978-1-4612-4584-1_21.
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Amin, Insha, Azher Arafah, Muneeb U. Rehman, et al. "A Crosstalk Between Antiinflammatory and Wound-Healing Properties of Honey." In Therapeutic Applications of Honey and its Phytochemicals. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7305-7_15.
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Nancy, S. Patricia, S. Shanchana, S. Udhayanila, T. Divya, and Bharathi. "Assessment of Antibacterial Properties of Natural Extracts for Wound Healing Applications." In Advances in Sustainability Science and Technology. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4321-7_7.
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Zabary, Yishaia, and Assaf Zaritsky. "A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration." In Bioimage Data Analysis Workflows ‒ Advanced Components and Methods. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-76394-7_8.
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AbstractIn this chapter we present a MATLAB-based computational pipeline for the quantification of monolayer migration assays. Wound healing assay (or scratch assay) is a commonly used in vitro assay to assess collective cell migration. Our pipeline outputs traditional and spatiotemporal readouts that quantify the group migration properties and was previously used for a screen that included thousands of time-lapse sequences. You will learn how to execute the pipeline, the principles behind the design and implementation choices we made, pitfalls, tips, and tricks in using it.
Streszczenia konferencji na temat "And wound-healing properties"
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Butsyk, Anna, Yevhen Samokhin, Anastasiia Denysenko, et al. "Copper Nanoparticles in Ch/PLA Dressing Material Promotes Wound Healing." In 2024 IEEE 14th International Conference Nanomaterials: Applications & Properties (NAP). IEEE, 2024. http://dx.doi.org/10.1109/nap62956.2024.10739763.
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"Cytotoxic properties of humic substances-containing wound healing ointments." In Seventh International Conference on Humic Innovative Technologies "Humic substances and technologies for resilience" (HIT – 2022). NP CBR "Humus Sapiens", 2022. http://dx.doi.org/10.36291/hit.2022.052.
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Mak, Eva Yi-Wah, and Wallace Woon-Fong Leung. "Novel Nanofibrous Scaffold to Improve Wound Healing." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-64223.
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An antibacterial and biocompatible scaffold for fibroblasts proliferation based on chitosan has been developed. Chitosan solution is electrospun into uniform fibers of 100–200 nm in diameter that mimic the extracellular matrix of human skin. The fibrous mats are successfully cross-linked to be stable in acidic solution, which can be used to treat acute wounds. The crosslinked fibrous mats display antibacterial properties toward Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The mechanical properties of fibrous mats are shown to be comparable to native skin dermis which protects the skin wound.
4
Chin, Jessica, Ibrahim Zeid, and Sagar Kamarthi. "Tools and Components of Wound Healing Assessment." In ASME 2013 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/detc2013-13270.
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Chronic wound assessment and analysis has long been a major healthcare issue. Chronic wound management and treatment cost billions of dollars each year. The research to alleviate the burden of non-healing wounds and predicting when they will heal is progressing at incremental pace. Characteristics of a chronic wound are unique to both the patient and wound itself. Like a fingerprint, each wound has a unique set of properties that tell a story about its health and viability. Although each person’s wound is individual, there are a few underlying pathologies that are common amongst all wounds. For example, all wounds have a definite surface area, depth, and temperature at any given time. By knowing these common characteristics across all wounds, we can use both historical data and collected data to determine wound healing patterns and wound healing rates. The purpose of this study is to develop an algorithm that uses photography and statistical modeling to predict an approximate wound healing rate for lower appendage wounds. We focus on lower appendage wounds with a depth of 1–2 mm because lower appendage wounds account for approximately 70% of wounds seen at wound clinics.
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Khoda, Bashir, and Bahattin Koc. "Deformation Modeling of Soft Tissue Scaffolds for Wound Healing." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64662.
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Within tissue engineering (TE), one of the major research theme is on synthetic scaffold design. Most research emphasis on the material that has to be biocompatible and biodegradable over time and shows proper cell attachment properties. And traditional scaffold fabrication technique use chemical process resulting in uncontrolled porosity along the structure. Development of Solid Free Form (SFF) technique and improvement in some biomaterial properties provides the leverage of using these techniques to fabricate controlled and interconnected porous scaffold structure. These improved membrane/scaffolds are mostly regular porous structure and when applied in wound area various forces like bandage, contraction and self weight act upon that and cause deformation. As a result, the geometry and the designed porosity changes which eventually alters the desired choreographed functionality such as material concentration, design parameters, cytokines distribution over the wound device geometry. This balance often presents a tradeoff between a denser scaffold providing better mechanical function and a more porous scaffold providing better biofactor delivery, cell proliferation, pathways for nutrients and waste transportation. In this work, a novel scaffold modeling approach of “desired porosity with variational filament distance” has been proposed that will minimize the change in effective porosity with the designed porosity and thus will give a better functionality of such membrane providing both structural integrity and proper bioreactor environment. The proposed methodology has been implemented in this paper and illustrative examples are provided. Also a comparison result of measured effective porosity has been presented between proposed design model and conventional fixed filament distance scaffolds membrane.
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Thaweboon, Sroisiri, Ratchaporn Srichan, Supaporn Mala, and Boonyanit Thaweboon. "The Development of Artificial Saliva with Oral Wound Healing Property." In 2023 7th International Conference on Nanomaterials and Biomaterials & 2023 5th Asia Conference on Material and Manufacturing Technology. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-wc6acn.
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Wound healing is a normal biological mechanism of the body that helps to maintain the integrity of the tissue. In this process, fibroblasts play an important role in supporting wound healing by migrating to the injury site and laying down a new extracellular matrix. Oral wounds heal more rapidly than skin wounds due to the presence of saliva. However, a reduced salivary flow rate or hyposalivation is frequently found in some patients due to their systemic conditions or intake of various medications. In order to control or treat hyposalivation, the use of artificial saliva is recommended for these patients. Various agents were added to artificial saliva to improve its properties. The aim of the present study was to investigate the effect of artificial saliva containing vanillin on the wound healing of human gingival fibroblasts by inducing cell migration in vitro. Human gingival fibroblasts isolated from human gingiva were purchased from Scien Cell Research Laboratories, USA. The migratory ability of fibroblasts was performed on a confluent monolayer by the wound healing scratch assay. Artificial saliva with different concentrations of vanillin (0.12% to 4% w/v) was added and incubated for 24 h. Artificial saliva without vanillin was used as a control. The migration cells were fixed with 25% methanol and 0.2% toluidine blue. In vitro cell migration to the wound area was determined by photographing with an inverted microscope coupled to a digital camera (Nikon D 5100). In the presence of 0.25%, 0.5%, and 1% w/v vanillin-containing artificial saliva, human gingival fibroblasts had a significantly higher potential to migrate into the wound area than a control (p-value <0.05). Data from this study provides the first scientific evidence to demonstrate the benefits of using artificial saliva containing vanillin to maintain healthy gums and accelerate oral wound healing. Rinsing the mouth with this artificial saliva is recommended as the most preferable method for moistening and lubricating the mouth and facilitating the healing of oral wounds in patients with hyposalivation.
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Wolf, S., D. Häussinger, and JG Bode. "Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM." In 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0038-1677111.
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Koppes, Ryan A., Andrew K. Mason, Sarah B. Peters, Shayoni Ray, Melinda Larsen, and David T. Corr. "The Viscoelastic Properties of Mouse Embryonic Salivary Glands." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14600.
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Normal organ development, function, and repair are coordinated by interactions between the epithelium and the surrounding stromal cell populations. Cellular function and homeostasis are controlled by an array of chemical and physical cues originating from the cells themselves and from the surrounding extracellular matrix (ECM). Both the endogenous cell population and ECM modulate and rely on the maintenance of basal level of tension within the tissue as a cue for growth and differentiation [1]. Furthermore, the loss of this tensional homeostasis is synonymous with many pathological conditions including; cancer, wound healing, and degenerative diseases [2].
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Organ, Adina, Mariana Jian, Vitalie Cobzac, et al. "In vivo studies of lavender extracts for healing thermal injury in rats." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab04.
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In recent years, herbal extracts obtained from medicinal plants have gained increasing interest in treatment of wounds. About 450 plant species having wound healing properties have been identified. The present knowledge of the wound healing process comprises coagulation, inflammation, proliferation, formation and accumulation of fibrous tissues, collagen deposition, epithelialization, contraction of wound with formation of granulation tissues, remodeling and maturation [1]. The selection of research methods was carried out in accordance with objectives of the work: determining of regeneration properties of Lavandula angustifolia extract fractions with assessment of the influence on the regeneration of thermal injuries of the epithelium in laboratory animals, through the evaluation, when they are administered in different fractions. Sodium carboxymethylcellulose gels containing 5% lavender extracts were investigated in this study for regenerative properties in thermal injury repair in laboratory rats. "Levomicol" ointment was administered as a control. Gel formulations were administered daily to lesions in white rats. Animals were divided into 6 groups of 3 individuals. After the observation period (of 7 days) the animals were euthanized and the epithelium harvested for the study of regeneration indices. As a result of this study, the histological sections studied in hematoxylin and eosin (HE) staining showed partial regeneration both at the epithelial and dermal levels. Regeneration indices have shown that gels containing lavender extracts can increase the proliferation of epithelial cells, the inflammatory processes being decreased.
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Irham, Wardatul Husna, Marpongahtun, and Sajaratud Dur. "Improving mechanical properties of bacterial cellulose with supplemented Curcuma Longa Linn extract for wound healing." In THE 2ND NATIONAL CONFERENCE ON MATHEMATICS EDUCATION (NACOME) 2021: Mathematical Proof as a Tool for Learning Mathematics. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0114810.
Pełny tekst źródłaRaporty organizacyjne na temat "And wound-healing properties"
1
Cabrera, Anahi Maldonado, Blayra Maldonado Cabrera, Dalia Isabel Sánchez Machado, and Jaime López Cervantes. Wound healing therapeutic effect of chitosan nanofibers: a systematic review and meta- analysis of animal studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.10.0121.
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Review question / Objective: Review question: Does chitosan base nanofibers has significant wound healing therapeutics effects in animal models? A preclinical systematic review of intervention will be carried out to evaluate the therapeutic effects of chitosan nanofibers on animal skin lesions. The PICO (Population, Intervention, Comparator, Outcome) scheme will be used: Intervention: full-thickness skin lesions, and the application of chitosan nanofibers as treatment for animal skin lesions. Regardless of the concentration of chitosan or other added compounds used. Comparison: No intervention, topical placebo agents and standard skin lesions treatments will be included. Outcome: wound healing area, wound closure, type of wound closure (first, second or third intention), healing time, infectious processes (antibacterial/antifungal properties), blood loss (hemostatic properties) and adverse effects.