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Hillman, Prima F., Chaeyoung Lee, and Sang-Jip Nam. "Microbial Natural Products with Wound-Healing Properties." Processes 11, no. 1 (2022): 30. http://dx.doi.org/10.3390/pr11010030.
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Wound healing continues to pose a challenge in clinical settings. Moreover, wound management must be performed properly and efficiently. Acute wound healing involves multiple cell divisions, a new extracellular matrix, and the process of formation, such as growth factors and cytokines, which are released at the site of the wound to regulate the process. Any changes that disrupt the healing process could cause tissue damage and prolong the healing process. Various factors, such as microbial infection, oxidation, and inflammation, can delay wound healing. In order to counter these problems, utilizing natural products with wound-healing effects has been reported to promote this process. Several natural products have been associated with wound healing, most of which are from medicinal plants. However, secondary microbial metabolites have not been extensively studied for their wound-healing properties. Further, investigations on the wound-healing control of natural microbial products are required due to a lack of studies. This review discussed the in vivo and in vitro research on the wound healing activities of natural microbial products, which may assist in the development of better wound treatments in the future.
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Green, A. E. "Wound healing properties of honey." British Journal of Surgery 75, no. 12 (1988): 1278. http://dx.doi.org/10.1002/bjs.1800751236.
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Choudhary, Vikram, and H. G. Shivakumar. "A REVIEW ON CURCUMIN: WOUND HEALING PROPERTIES AND BIOMARKERS OF WOUND HEALING." International Research Journal Of Pharmacy 9, no. 9 (2018): 1–5. http://dx.doi.org/10.7897/2230-8407.099179.
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Ibrahim, Nurul, Sok Wong, Isa Mohamed, et al. "Wound Healing Properties of Selected Natural Products." International Journal of Environmental Research and Public Health 15, no. 11 (2018): 2360. http://dx.doi.org/10.3390/ijerph15112360.
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Wound healing is a complex process of recovering the forms and functions of injured tissues. The process is tightly regulated by multiple growth factors and cytokines released at the wound site. Any alterations that disrupt the healing processes would worsen the tissue damage and prolong repair process. Various conditions may contribute to impaired wound healing, including infections, underlying diseases and medications. Numerous studies on the potential of natural products with anti-inflammatory, antioxidant, antibacterial and pro-collagen synthesis properties as wound healing agents have been performed. Their medicinal properties can be contributed by the content of bioactive phytochemical constituents such as alkaloids, essential oils, flavonoids, tannins, saponins, and phenolic compounds in the natural products. This review highlights the in vitro, in vivo and clinical studies on wound healing promotions by the selected natural products and the mechanisms involved.
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Li, Rongkai, Qinbing Qi, Chunhua Wang, Guige Hou, and Chengbo Li. "Self-Healing Hydrogels Fabricated by Introducing Antibacterial Long-Chain Alkyl Quaternary Ammonium Salt into Marine-Derived Polysaccharides for Wound Healing." Polymers 15, no. 6 (2023): 1467. http://dx.doi.org/10.3390/polym15061467.
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The development of hydrogels as wound dressings has gained considerable attention due to their promising ability to promote wound healing. However, in many cases of clinical relevance, repeated bacterial infection, which might obstruct wound healing, usually occurs due to the lack of antibacterial properties of these hydrogels. In this study, we fabricated a new class of self-healing hydrogel with enhanced antibacterial properties based on dodecyl quaternary ammonium salt (Q12)-modified carboxymethyl chitosan (Q12-CMC), aldehyde group- modified sodium alginate (ASA), Fe3+ via Schiff bases and coordination bonds (QAF hydrogels). The dynamic Schiff bases and coordination interactions conferred excellent self-healing abilities to the hydrogels, while the incorporation of dodecyl quaternary ammonium salt gave the hydrogels superior antibacterial properties. Additionally, the hydrogels displayed ideal hemocompatibility and cytocompatibility, crucial for wound healing. Our full-thickness skin wound studies demonstrated that QAF hydrogels could result in rapid wound healing with reduced inflammatory response, increased collagen disposition and improved vascularization. We anticipate that the proposed hydrogels, possessing both antibacterial and self-healing properties, will emerge as a highly desirable material for skin wound repair.
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Dodi, Gianina, Rosina E. Sabau, Bianca E. B. Crețu, and Ioannis Gardikiotis. "Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing." Pharmaceutics 15, no. 8 (2023): 2152. http://dx.doi.org/10.3390/pharmaceutics15082152.
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It is acknowledged that the presence of antioxidants boosts the wound-healing process. Many biopolymers have been explored over the years for their antioxidant potential in wound healing, but limited research has been performed on gum structures and their derivatives. This review aims to evaluate whether the antioxidant properties of gellan and guar gums and wound healing co-exist. PubMed was the primary platform used to explore published reports on the antioxidant wound-healing interconnection, wound dressings based on gellan and guar gum, as well as the latest review papers on guar gum. The literature search disclosed that some wound-healing supports based on gellan gum hold considerable antioxidant properties, as evident from the results obtained using different antioxidant assays. It has emerged that the antioxidant properties of guar gum are overlooked in the wound-healing field, in most cases, even if this feature improves the healing outcome. This review paper is the first that examines guar gum vehicles throughout the wound-healing process. Further research is needed to design and evaluate customized wound dressings that can scavenge excess reactive oxygen species, especially in clinical practice.
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Hong, Zhiwu, Lei Wu, Zherui Zhang, et al. "Self-Healing Supramolecular Hydrogels with Antibacterial Abilities for Wound Healing." Journal of Healthcare Engineering 2023 (February 9, 2023): 1–10. http://dx.doi.org/10.1155/2023/7109766.
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Wound healing due to skin defects is a growing clinical concern. Especially when infection occurs, it not only leads to impair healing of the wound but even leads to the occurrence of death. In this study, a self-healing supramolecular hydrogel with antibacterial abilities was developed for wound healing. The supramolecular hydrogels inherited excellent self-healing and mechanical properties are produced by the polymerization of N-acryloyl glycinamide monomers which carries a lot of amides. In addition, excellent antibacterial properties are obtained by integrating silver nanoparticles (Ag NPs) into the hydrogels. The resultant hydrogel has a demonstrated ability in superior mechanical properties, including stretchability and self-healing. Also, the good biocompatibility and antibacterial ability have been proven in hydrogels. Besides, the prepared hydrogels were employed as wound dressings to treat skin wounds of animals. It was found that the hydrogels could significantly promote wound repair, including relieving inflammation, promoting collagen deposition, and enhancing angiogenesis. Therefore, such self-healing supramolecular hydrogels with composite functional nanomaterials are expected to be used as new wound dressings in the field of healthcare.
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Brown, Stuart J., Farhana Surti, Paul Sibbons, and Lilian Hook. "Wound healing properties of a fibrin-based dermal replacement scaffold." Biomedical Physics & Engineering Express 8, no. 1 (2021): 015025. http://dx.doi.org/10.1088/2057-1976/ac4176.
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Abstract When serious cutaneous injury occurs, the innate wound healing process attempts to restore the skin’s appearance and function. Wound healing outcome is affected by factors such as contraction, revascularisation, regeneration versus fibrosis and re-epithelialisation and is also strongly influenced by the pattern and extent of damage to the dermal layer. Dermal replacement scaffolds have been designed to substitute for lost tissue, provide a structure to promote dermal regeneration, and aid skin grafting, resulting in a superior healing outcome. In this study the wound healing properties of a novel fibrin-alginate dermal scaffold were assessed in the porcine wound healing model and also compared to two widely used dermal scaffolds and grafting alone. The fibrin-alginate scaffold, unlike the other scaffolds tested, is not used in combination with an overlying skin graft. Fibrin scaffold treated wounds showed increased, sustained superficial blood flow and reduced contraction during early healing while showing comparable wound closure, re-epithelialisation and final wound outcome to other treatments. The increase in early wound vascularisation coupled with a decrease in contraction and no requirement for a skin graft suggest that the fibrin-based scaffold could provide an effective, distinctive treatment option to improve healing outcomes in human patients.
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Alven, Sibusiso, Vuyolwethu Khwaza, Opeoluwa O. Oyedeji, and Blessing A. Aderibigbe. "Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds." Pharmaceutics 13, no. 7 (2021): 961. http://dx.doi.org/10.3390/pharmaceutics13070961.
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The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.
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Firda, Rahmania, and Fawzy Ahmad. "Efficacy of Honey-Based Wound Dressing Versus Hydrogel-Based Wound Dressing in Wound Healing Process: A Literature Review." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 04, no. 05 (2024): 812–17. https://doi.org/10.5281/zenodo.11125857.
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<strong>Introduction:</strong> Wound dressing is a fundamental aspect of modern healthcare, encompassing a diverse range of materials and techniques aimed at optimizing the healing process while safeguarding against infection and further injury. By understanding the specific benefits of different types of wound dressings, healthcare professionals can optimize the healing process and improve patient outcomes <strong>Methods:</strong> This literature review was compiled using information from various open access online databases. Data were collected and analyzed. <strong>Results and Discussions: </strong>Honey dressing demonstrates superior efficacy compared to hydrogel dressing in wound management. Its multifaceted properties, such as potent antimicrobial activity, tissue regeneration promotion, and anti-inflammatory effects, render it a superior option for wound healing throughout all stages. Additionally, honey is more cost-effective than hydrogel and more easily accessible. <strong>Conclusion:</strong> The efficacy of honey dressing surpasses that of hydrogel dressing in wound management. Honey's multifaceted properties, including its potent antimicrobial activity, ability to promote tissue regeneration, and anti-inflammatory effects, make it a superior choice for wound healing across all phases.
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Jahan, Nusrat, Rifat Ara Neera, iffat Ara, Humayra Akhter Himu, and Jannatul Ferdush. "Development of Antimicrobial Textile Used to Dressing for Wound Healing." Journal of Natural Science and Textile Techonology (JNSTT) 2, no. 1 (2023): 32–38. https://doi.org/10.5281/zenodo.8275054.
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Ocimum basilicum plant has medicinal value and it has been used as a good source of ayurvedic medicine. This work presents the wound healing properties of dyed viscose and silk fabric with Ocimum basilicum plant extract by cold pad batch method. Cold pad batch dyeing technology was considered for incorporating antimicrobial properties that will support wound healing into viscose and silk fabric, whereas Ocimum basilicum plant extract was used as a natural antimicrobial agent. Both dyed antimicrobial textile dressings showed good wound healing properties, whereas silk dressing displayed better healing properties.
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Mazurek, Łukasz, Mateusz Szudzik, Mateusz Rybka, and Marek Konop. "Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing." Biomolecules 12, no. 12 (2022): 1852. http://dx.doi.org/10.3390/biom12121852.
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The skin, acting as the outer protection of the human body, is most vulnerable to injury. Wound healing can often be impaired, leading to chronic, hard-to-heal wounds. For this reason, searching for the most effective dressings that can significantly enhance the wound healing process is necessary. In this regard, silk fibroin, a protein derived from silk fibres that has excellent properties, is noteworthy. Silk fibroin is highly biocompatible and biodegradable. It can easily make various dressings, which can be loaded with additional substances to improve healing. Dressings based on silk fibroin have anti-inflammatory, pro-angiogenic properties and significantly accelerate skin wound healing, even compared to commercially available wound dressings. Animal studies confirm the beneficial influence of silk fibroin in wound healing. Clinical research focusing on fibroin dressings is also promising. These properties make silk fibroin a remarkable natural material for creating innovative, simple, and effective dressings for skin wound healing. In this review, we summarise the application of silk fibroin biomaterials as wound dressings in full-thickness, burn, and diabetic wounds in preclinical and clinical settings.
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Kavish, P., R. Kalpana, and Vinay Kumar. "Doxycycline Drug Release Property of Glutaraldehyde Crosslinked Hydrogel." Journal of Pharmacy and Bioallied Sciences 16, Suppl 2 (2024): S1204—S1206. http://dx.doi.org/10.4103/jpbs.jpbs_541_23.
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ABSTRACT Delayed wound healing is one of the most common problems associated with diabetic patients. There are several factors associated with delayed wound healing. It has been observed that if not cured the wound healing takes a long time. This is the reason that researchers are engaged in developing sustainable, biodegradable, biocompatible, and effective wound-healing dressings. However, it has been observed that the traditional wound-healing bandages have drawbacks such as allergies and less efficiency in the absorption of wound exudate. To fill the gap, hydrogels have been developed recently which have higher absorption capacity. In addition, they pose slow drug release properties. Therefore, the present study was conducted to prepare an effective and promising hydrogel that has high drug absorption and release properties.
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Ghosh, Prasanta Kumar, and Anjali Gaba. "Phyto-Extracts in Wound Healing." Journal of Pharmacy & Pharmaceutical Sciences 16, no. 5 (2013): 760. http://dx.doi.org/10.18433/j3831v.
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Data generated through systematic investigation, carried out on the evaluation of phyto-extracts on wound healing research during the last 20 years have been compiled. About 450 plant species having wound healing properties have been identified. The present knowledge of the wound healing process comprise coagulation, inflammation, proliferation, formation and accumulation of fibrous tissues, collagen deposition, epithelialization, contraction of wound with formation of granulation tissues, remodeling and maturation. The constituents of the plant extracts modulate one or more of the above stages. It was the endeavor to identify the active constituents responsible for antimicrobial activity, free radical scavenging properties, stimulators of enhanced collagen production and/or angiogenesis promoters with identification of lead scaffold chemical structures. Multiple phytochemicals concentrated and blended in optimal concentrations, are expected to be available in future years to carry out multi-tasking efforts in wound healing as more knowledge about the properties of the key constituents are unveiled.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
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Abdulhameed, Ola Adil, and Haitham Mahmood Kadhim. "Exploring the Role of Pleurotus Ostreatus as an Ointment Formulation in Inducing Wound Healing in Mice Skin." Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (2024): S243—S246. http://dx.doi.org/10.4103/jpbs.jpbs_480_23.
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ABSTRACT Background: Natural compounds rich in secondary metabolites have gained attention as alternative therapies for wound healing due to their potential advantages over conventional treatments. Pleurotus ostreatus mushrooms have been identified for their wound-healing properties, including promoting neovascularization, epithelialization, and collagen synthesis. Material and Methods: This study aimed to investigate the wound-healing properties of different doses of topical Extract of Pleurotus ostreatus in albino mice using an excisional wound model. The experimental design involved administering various concentrations of the extract to evaluate its effects on wound closure and histopathological and immunohistochemical parameters. Results: The results revealed significant wound closure and improvements in histopathological and immunohistochemical parameters in mice treated with Pleurotus ostreatus extract. These findings suggest the potential of Pleurotus ostreatus extract as a viable wound healing agent. Conclusion: Pleurotus ostreatus extract demonstrates promising wound-healing capabilities, including promoting wound closure and enhancing histopathological and immunohistochemical parameters in albino mice. Further research is warranted to explore its full therapeutic potential and mechanism of action in wound healing.
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Chittoria, Ravi Kumar. "Biosilk bilayered scaffold Application in Wound bed Preparation of Thermal Burns Wound." Clinical Research and clinical Trials 10, no. 05 (2024): 01–04. http://dx.doi.org/10.31579/2693-4779/214.
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Haemostasis, inflammation, proliferation, and remodelling are the steps that comprise the complex biological process of wound healing. Chronic wounds often remain static in the inflammatory stage of wound healing beyond the expected duration and resist healing. Biosilk or biomodified silk dressing is believed to aid in accelerating the wound healing process. The combination bio functionalised silk matrix with silver oxide and Centella asiatica, a medicinal plant with wound healing properties, has been found to be effective in managing chronic non-healing wounds.
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Della Sala, Francesca, Gennaro Longobardo, Antonio Fabozzi, Mario di Gennaro, and Assunta Borzacchiello. "Hyaluronic Acid-Based Wound Dressing with Antimicrobial Properties for Wound Healing Application." Applied Sciences 12, no. 6 (2022): 3091. http://dx.doi.org/10.3390/app12063091.
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Wound healing is a naturally occurring process that can be aided by a wound dressing properly designed to assure an efficient healing process. An infection caused by several microorganisms could interfere with this process, delaying or even impairing wound healing. Hyaluronic acid (HA), a main constituent of the extracellular matrix (ECM) of a vertebrate’s connective tissue, represents a promising biomaterial for wound dressing thanks to its intrinsic biocompatibility, hydrophilicity and bacteriostatic properties. In this review, different and recent types of HA-based wound dressings endowed with intrinsic antimicrobial properties or co-adjuvated by antimicrobial natural or synthetic agents are highlighted.
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Fedosov, Pavel, Vladimir Nikolaevsky, Yury Chernov, Anna Buzlama, Alexey Slivkin, and Svetlana Provotorova. "PRECLINICAL STUDY OF THE EFFICACY AND SAFETY OF WOUND HEALING GEL CONTAINING CHITOSAN, TAURINE AND ALLANTOIN." Research Results in Pharmacology 3, no. (2) (2017): 14–28. https://doi.org/10.18413/2313-8971-2017-3-2-14-28.
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Introduction: The paper deals with the problem of wound healing, which is considered to remain one of the most pressing challenges of the modern medicine, despite a large variety of wound healing preparations. This results from a high level of domestic and military traumatism of the population, and the fact that many registered medications do not meet the requirements for modern wound healing preparations. Objectives: To develop gel containing chitosan, taurine, allantoin, and to experimentally investigate its wound healing properties in pre-clinical studies on laboratory animals. Methods: The methodological approach was based on a range of theoretical, pharmacological, toxicological, histological, statistical, physico-chemical, biopharmaceutical, rheological methods, which ensured the development of an optimal, safe and effective wound healing preparation in the gel dosage form. Results: The developed chitosan gel containing taurine and allantoin meets the major modern requirements for wound and burn care. Physico-chemical compatibility of the chitosan gel components with taurine and allantoin were proved in the experimental studies. When applied either singly or repeatedly on the skin, the developed gel is reported to be of low toxicity; in case of linear wounds, it demonstrates wound-healing properties, ensuring the increase of wound-disruption strength 1.5 times more in comparison with the control; in case of planar full-thickness skin wounds, it provides earlier complete healing (4 days earlier than in the control) and full epithelium recovery in the area of a wound defect. The given gel possesses burn-treating properties exceeding the efficiency of the "Solcoseryl" gel and reducing the half-healing period by 28%. When applied topically, the chitosan gel containing taurine and allantoin reveals anti-inflammatory and capillary-protective properties of moderate degree. Conclusion: It is possible to use 1.0% chitosan gel with 4.0% taurine and 0.5% allantoin to accelerate healing and provide epithelization without cosmetic defects of conditionally aseptic wounds and thermal skin burns up to IIIa degree to 1% of the body surface area; the gel should be applied 1-3 times a day locally, 0.5 g directly to the wound surface.
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Gbedema, StephenY, Kisseih Emelia, Adu Francis, Annan Kofi, and Woode Eric. "Wound healing properties and kill kinetics ofClerodendron splendensG. Don, a ghanaian wound healing plant." Pharmacognosy Research 2, no. 2 (2010): 63. http://dx.doi.org/10.4103/0974-8490.62948.
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Ajith, Govindaraj, Ganesan Padmini Tamilarasi, Govindaraj Sabarees, et al. "Recent Developments in Electrospun Nanofibers as Delivery of Phytoconstituents for Wound Healing." Drugs and Drug Candidates 2, no. 1 (2023): 148–71. http://dx.doi.org/10.3390/ddc2010010.
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Wound healing is an unresolved therapeutic challenge for the medical community, as wound assessment and management is a complex procedure involving numerous factors that play a significant role in the healing process. Several factors, including bacterial infections, underlying conditions, malnutrition, obesity, aging, and smoking are the most frequent causes of a delayed wound-healing process. The shortcomings related to the currently used wound dressings include poor antimicrobial properties, weak mechanical features, poor biodegradability, biocompatibility, etc. Modern medicine has expanded the use of phytoconstituents based on nanotechnology to regenerate and repair soft and hard tissues. Electrospun nanofiber platforms are the most recent and promising among many types of conventional wound dressings due to their distinct characteristics. Many plant extracts and their phytoconstituents are well-known as adequate substitutes for wound healing agents because of their wide range of active ingredients, accessibility, and limited side effects. Incorporating these phytoconstituents into electrospun nanofibers combines the structural properties of the nanofibers with the antibacterial and therapeutic properties of the plants, making the nanofibers ideal for use as wound dressings. This review focuses on the antibacterial and therapeutic applications of nanofiber wound dressings containing phytoconstituents and their potential to revolutionize wound healing.
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Esa, Nur Eszaty Farain, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, et al. "A Review on Recent Progress of Stingless Bee Honey and Its Hydrogel-Based Compound for Wound Care Management." Molecules 27, no. 10 (2022): 3080. http://dx.doi.org/10.3390/molecules27103080.
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Stingless bee honey has a distinctive flavor and sour taste compared to Apis mellifera honey. Currently, interest in farming stingless bees is growing among rural residents to meet the high demand for raw honey and honey-based products. Several studies on stingless bee honey have revealed various therapeutic properties for wound healing applications. These include antioxidant, antibacterial, anti-inflammatory, and moisturizing properties related to wound healing. The development of stingless bee honey for wound healing applications, such as incorporation into hydrogels, has attracted researchers worldwide. As a result, the effectiveness of stingless bee honey against wound infections can be improved in the future to optimize healing rates. This paper reviewed the physicochemical and therapeutic properties of stingless bee honey and its efficacy in treating wound infection, as well as the incorporation of stingless bee honey into hydrogels for optimized wound dressing.
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Bakari, G. G., S. A. Mshamu, M. H. Ally, R. A. Max, and H. Bai. "In-vitro Wound Healing Properties of Commiphora swynnertonii Resinous Extracts." Tanzania Veterinary Journal 38 (September 4, 2021): 32–37. http://dx.doi.org/10.4314/tvj.v38i1.6s.
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Wound healing is a complex multicellular process involving many cell types which include; inflammatory cells, endothelial cells, fibroblasts and keratinocytes. The process involves an orderly sequence of events with four overlapping phases namely; haemostasis, inflammatory, proliferation and remodeling phases. The process can be facilitated by the use of wound healing agents including herbal remedies from plants. In this study the main objective was to evaluate the in vitro wound healing activity of the resin obtained from Commiphora swynnertonii (C.swynnertonii). First the NIH -3T3 cells viability were evaluated using (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl Tetrazolium Bromide (MTT) assay. Then the wound scratch assay model was used to evaluate cellular proliferation, closure of the wound and release of matrix metalloproteinase enzymes. Results indicate differences in mean cell viability between different concentrations within 24 hours of incubation. The highest viability was recorded at the concentration of 1% (v/v). The in-vitro wound scratch assay showed positive NIH - 3T3 cells proliferation on the wound area and cells migration when compared with control group (without treatment) at 0 and 24 hours. In addition, C. swynnertonii was able to stimulate secretion of MMP-2 release from NIH - 3T3 cells. MMP-2 is an important enzyme for extracellular matrix remodeling during wound healing suggesting that C. swynnertonii promotes wound healing by stimulating cell proliferation and production of MMP-2 in a mechanism that is currently not known.
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Sri Venkatesh, Uriti, Vamseedhar Annam, Aruna Kumari Nakkella, Abhijit S. Welankiwar, and Pradyumna S. Keche. "Nano Materials for Wound Healing." Journal of Neonatal Surgery 14, no. 3 (2025): 186–97. https://doi.org/10.52783/jns.v14.2213.
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Wound healing is a complex biological process involving multiple cellular and molecular mechanisms, which can be significantly enhanced through advanced therapeutic approaches. In recent years, nanomaterials have emerged as promising candidates for accelerating wound healing due to their unique physicochemical properties, biocompatibility, and antimicrobial effects. This paper explores the role of various nanomaterials, including metal nanoparticles, carbon-based nanomaterials, polymeric nanoparticles, and nanocomposites, in promoting tissue regeneration, reducing infection rates, and improving overall wound healing outcomes. Nanoparticles such as silver, gold, zinc oxide, and copper oxide exhibit strong antimicrobial properties that prevent infections, a major impediment to effective wound healing. Polymeric nanoparticles, including chitosan and poly(lactic-co-glycolic acid) (PLGA), offer controlled drug release, enhancing the delivery of growth factors and bioactive agents directly to the wound site. Carbon-based nanomaterials, such as graphene oxide and carbon nanotubes, provide structural support and modulate cellular responses, facilitating fibroblast proliferation and angiogenesis. In addition, hybrid nanocomposites that combine multiple nanomaterials have shown synergistic effects, enhancing cell migration and extracellular matrix remodeling. The mechanisms by which nanomaterials facilitate wound healing include modulation of inflammatory responses, promotion of cell adhesion and proliferation, and stimulation of angiogenesis. Additionally, nanomaterials offer significant advantages over conventional wound healing methods, such as improved mechanical strength, reduced cytotoxicity, and targeted therapeutic delivery. Despite these advantages, challenges remain in terms of biocompatibility, potential toxicity, and large-scale production of nanomaterials for clinical applications. Further research is needed to optimize the physicochemical properties of nanomaterials to enhance their efficacy and safety for human use. This paper provides an in-depth analysis of the latest advancements in nanotechnology-based wound healing strategies, highlighting their potential for transforming clinical wound care. By leveraging the unique properties of nanomaterials, future research can focus on developing innovative, cost-effective, and patient-friendly wound healing solutions that minimize complications and accelerate tissue regeneration. The integration of nanomaterials in wound care holds immense promise for addressing chronic and acute wounds, ultimately improving patient outcomes and quality of life.
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Patil, Tejal V., Dinesh K. Patel, Sayan Deb Dutta, Keya Ganguly, Aayushi Randhawa, and Ki-Taek Lim. "Carbon Nanotubes-Based Hydrogels for Bacterial Eradiation and Wound-Healing Applications." Applied Sciences 11, no. 20 (2021): 9550. http://dx.doi.org/10.3390/app11209550.
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Biocompatible nanomaterials have attracted enormous interest for biomedical applications. Carbonaceous materials, including carbon nanotubes (CNTs), have been widely explored in wound healing and other applications because of their superior physicochemical and potential biomedical properties to the nanoscale level. CNTs-based hydrogels are widely used for wound-healing and antibacterial applications. CNTs-based materials exhibited improved antimicrobial, antibacterial, adhesive, antioxidants, and mechanical properties, which are beneficial for the wound-healing process. This review concisely discussed the preparation of CNTs-based hydrogels and their antibacterial and wound-healing applications. The conductive potential of CNTs and their derivatives is discussed. It has been observed that the conductivity of CNTs is profoundly affected by their structure, temperature, and functionalization. CNTs properties can be easily modified by surface functionalization. CNTs-based composite hydrogels demonstrated superior antibacterial potential to corresponding pure polymer hydrogels. The accelerated wound healing was observed with CNTs-based hydrogels.
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Sneha, A. Vikhe Abhishek R. Putale Prashant M. Rane Rohit D. Nagare Aman S. Pinjari. "Formulation Development & Evaluation Of Herbal Cream For Wound Healing Activity." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 610–15. https://doi.org/10.5281/zenodo.11186336.
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This study focuses on the development and evaluation of a novel wound healing cream aimed at promoting efficient wound repair and tissue regeneration. The cream formulation includes key ingredients known for their therapeutic properties, including anti-inflammatory, antimicrobial, and skin regeneration-promoting agents. Preliminary results indicate that the wound healing cream exhibits promising properties, including significant antimicrobial activity, enhanced cell migration and proliferation, reduced inflammation, and accelerated wound closure rates compared to control groups. Histological analysis revealed improved collagen deposition and angiogenesis in treated wounds, suggesting enhanced tissue repair and regeneration. Overall, the findings from this study suggest that the developed wound healing cream holds potential for clinical applications in promoting effective wound healing, reducing healing time, and improving overall wound outcomes. Further clinical trials and optimization of the formulation are warranted to validate these initial findings and ensure the cream's safety and efficacy for human use.
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Mirrezaei, Neda, Rezvan Yazdian-Robati, Fatemeh Oroojalian, Amirhossein Sahebkar, and Maryam Hashemi. "Recent Developments in Nano-Drug Delivery Systems Loaded by Phytochemicals for Wound Healing." Mini-Reviews in Medicinal Chemistry 20, no. 18 (2020): 1867–78. http://dx.doi.org/10.2174/1389557520666200807133022.
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Wound healing is a multi-stage process during which a cascade of molecular and cellular events collaborate to restore the damaged tissue to its healthy state. The inability of the available therapies to effectively heal the wounds has imposed major problems on healthcare systems. Therefore, developing novel therapeutic modalities capable of enhancing wound healing process with no/or limited scar formation is of more importance. Different studies have investigated the potential of phytochemicals on the wound healing process. They have shown to exert anti-inflammatory, antioxidant, and antibacterial activities as well as promoting collagen synthesis and deposition, leading to enhancing wound healing. Nanotechnology, as an applicable knowledge, has provided versatile means to improve the efficiency and effectiveness of wound treatment. The application of nanoparticles has conferred various advantages in the field of wound treatment. They protect the therapeutics from degradation, release the cargo in a controlled fashion, possess healing properties, and can act as extracellular matrix (ECM) mimic. In this review, we discuss the naturally-occurring compounds with wound healing properties and their nano-formulation for skin wound therapy.
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Grafakou, Maria-Eleni, Aggeliki Diamanti, Eleytheria Simirioti, et al. "Wound Healing Effects from 3 Hypericum spp. Essential Oils." Planta Medica International Open 8, no. 02 (2021): e69-e77. http://dx.doi.org/10.1055/a-1492-3634.
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Abstract Hypericum species have a long-term use as wound healing agents, with the most common preparation being the infused oil from the aerial parts. It contains naphthodianthrones, phloroglucinols, and essential oil. An extensive literature survey shows that, unlike napthodianthrones and phloroglucinols, essential oils from Hypericum spp. have not yet been evaluated for their wound healing efficacy. The present study aims to assess the wound healing efficacy of essential oils from H. perforatum, a plant recognized in European Pharmacopoeia for having wound healing properties, as well from 2 other Hypericum species commonly used in Greece as wound healing agents since classical antiquity, namely, H. empetrifolium and H. triquetrifolium. So far, only the wound healing effects of Hypericum oil are known, which is a different herbal preparation containing nonvolatile compounds, while the essential oils under investigation contain only volatile constituents. The essential oils were subjected to GC-MS analyses. Wounds were created on the upper back of hairless SKH-hr1 mice. Healing was evaluated by clinical, histopathological, and biophysical assessment. The essential oils showed a significantly faster wound healing rate in comparison to the controls and the vehicle-treated groups. H. empetrifolium possessed the most significant healing properties while for H. perforatum and H. triquetrifolium skin inflammation persisted. The essential oils from Hypericum spp. showed promising results as wound healing agents and are likely to contribute to the wound healing efficacy of the Hypericum preparations. H. empetrifolium, being the most potent anti-inflammatory and wound healing agent, confirms the traditional use of this plant in Greece for wounds and skin inflammations.
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Shweta, Chandra. "Efficacy and Mechanisms of Karanja Ghrita in Wound Healing: An Ayurvedic Perspective." International Journal of Ayurveda360 1, no. 4 (2025): 230–42. https://doi.org/10.5281/zenodo.14887428.
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Abstract <strong>Introduction:</strong> Wound healing is a critical process in clinical care, where traditional therapies, such as those derived from Ayurveda, offer significant benefits. <em>Karanja Ghrita</em>, a formulation combining <em>Karanja </em>(Pongamia pinnata) oil and ghee, is traditionally used in <em>Ayurvedic</em> practices for its wound healing properties. This review explores its efficacy and underlying mechanisms in wound management. <strong>Methods: </strong> The paper examines the <em>Ayurvedic</em> principles of wound healing, which include the stages of <em>dushta vrana</em> (septic wound), shudh vrana (clean wound), <em>roohyamana vrana</em> (healing wound), and <em>roodha vrana</em> (healed wound). Emphasis is placed on the role of <em>Karanja Ghrita</em> in each phase of healing and its application in clinical settings. <strong>Results:</strong> <em>Karanja Ghrita</em> demonstrates significant therapeutic potential in wound healing. It acts through its antimicrobial, anti-inflammatory, and analgesic properties, promoting both wound purification (<em>vrana shodhana</em>) and healing (<em>vrana roopana</em>). The formulation enhances tissue regeneration, prevents infection, and accelerates wound closure, particularly in chronic and septic wounds. <strong>Discussion and Conclusion: </strong> The clinical benefits of <em>Karanja Ghrita </em>in wound healing extend beyond its traditional use, supported by its bioactive compounds. Its ability to support tissue regeneration, reduce inflammation, and prevent infections makes it a valuable adjunct in both acute and chronic wound care. By integrating <em>Ayurvedic</em> formulations like <em>Karanja Ghrita </em>with modern wound management, healthcare practitioners can offer holistic, effective treatments for various wound types. <strong>Keywords:</strong> <em>Karanja Ghrita, </em>Wound Healing<em>, Ayurvedic </em>Formulations<em>, Vrana Shodhana, </em>Chronic Wounds
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Chelu, Mariana, Adina Magdalena Musuc, Monica Popa, and Jose Calderon Moreno. "Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects." Gels 9, no. 7 (2023): 539. http://dx.doi.org/10.3390/gels9070539.
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Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of Aloe vera-based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of Aloe vera-based hydrogels are discussed. Mechanisms of therapeutic agents released from Aloe vera-based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of Aloe vera-based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into Aloe vera-based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of Aloe vera-based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of Aloe vera-based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.
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Yao, Han-Yun, Hong-Ru Lin, Geng-Pin Sue, and Yiu-Jiuan Lin. "Chitosan-based hydrogels prepared by UV polymerization for wound dressing." Polymers and Polymer Composites 27, no. 3 (2019): 155–67. http://dx.doi.org/10.1177/0967391118820477.
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Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.
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Tyavambiza, Caroline, Mervin Meyer, and Samantha Meyer. "Cellular and Molecular Events of Wound Healing and the Potential of Silver Based Nanoformulations as Wound Healing Agents." Bioengineering 9, no. 11 (2022): 712. http://dx.doi.org/10.3390/bioengineering9110712.
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Chronic wounds are a silent epidemic threatening the lives of many people worldwide. They are associated with social, health care and economic burdens and can lead to death if left untreated. The treatment of chronic wounds is very challenging as it may not be fully effective and may be associated with various adverse effects. New wound healing agents that are potentially more effective are being discovered continuously to combat these chronic wounds. These agents include silver nanoformulations which can contain nanoparticles or nanocomposites. To be effective, the discovered agents need to have good wound healing properties which will enhance their effectiveness in the different stages of wound healing. This review will focus on the process of wound healing and describe the properties of silver nanoformulations that contribute to wound healing.
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Wang, Sheng-Lan, Jia-Jun Zhuo, Shou-Min Fang, Wei Xu, and Quan-You Yu. "Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review." Biomolecules 14, no. 6 (2024): 723. http://dx.doi.org/10.3390/biom14060723.
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Wound infections may disrupt the normal wound-healing process. Large amounts of antibiotics are frequently used to prevent pathogenic infections; however, this can lead to resistance development. Biomaterials possessing antimicrobial properties have promising applications for reducing antibiotic usage and promoting wound healing. Silk sericin (SS) has been increasingly explored for skin wound healing applications owing to its excellent biocompatibility and antioxidant, antimicrobial, and ultraviolet-resistant properties. In recent years, SS-based composite biomaterials with a broader antimicrobial spectrum have been extensively investigated and demonstrated favorable efficacy in promoting wound healing. This review summarizes various antimicrobial agents, including metal nanoparticles, natural extracts, and antibiotics, that have been incorporated into SS composites for wound healing and elucidates their mechanisms of action. It has been revealed that SS-based biomaterials can achieve sustained antimicrobial activity by slow-release-loaded antimicrobial agents. The antimicrobial-loaded SS composites may promote wound healing through anti-infection, anti-inflammation, hemostasis, angiogenesis, and collagen deposition. The manufacturing methods, benefits, and limitations of antimicrobial-loaded SS materials are briefly discussed. This review aims to enhance the understanding of new advances and directions in SS-based antimicrobial composites and guide future biomedical research.
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Morales-González, Maria, Luis Eduardo Díaz, Carlos Dominguez-Paz, and Manuel F. Valero. "Insights into the Design of Polyurethane Dressings Suitable for the Stages of Skin Wound-Healing: A Systematic Review." Polymers 14, no. 15 (2022): 2990. http://dx.doi.org/10.3390/polym14152990.
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Dressings made with polyurethanes have been found to exhibit good and varied biological properties that make them good candidates for this application. However, as has been seen, the wound-healing process is complex, which includes four different stages. So far, the design and evaluation of polyurethane for wound dressing has focused on achieving good properties (mechanical, physicochemical, and biological), but each of them separates from the others or even directed at only one of the stages of skin wound-healing. Therefore, the aim of this systematic review is to explore the applications of polyurethanes in wound dressings and to determine whether could be designed to cover more than one stage of skin wound-healing. The PRISMA guidelines were followed. The current research in this field does not consider each stage separately, and the design of polyurethane dressings is focused on covering all the stages of wound healing with a single material but is necessary to replace polyurethanes in short periods of time. Additionally, little emphasis is placed on the hemostasis stage and further characterization of polyurethanes is still needed to correlate mechanical and physicochemical properties with biological properties at each stage of the wound-healing. Current research demonstrates an effort to characterize the materials physiochemically and mechanically, but in terms of their biological properties, most of the literature is based on the performance of histological tests of explants morphologically probing the compromised tissues, which give an indication of the potential use of polyurethanes in the generation of wound-healing dressings.
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Budai-Szűcs, Mária, Marco Ruggeri, Angela Faccendini, et al. "Electrospun Scaffolds in Periodontal Wound Healing." Polymers 13, no. 2 (2021): 307. http://dx.doi.org/10.3390/polym13020307.
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Periodontitis is a set of inflammatory conditions affecting the tissues surrounding the teeth predominantly sustained by bacterial infections. The aim of the work was the design and the development of scaffolds based on biopolymers to be inserted in the periodontal pocket to restore tissue integrity and to treat bacterial infections. Nanofibrous scaffolds were prepared by means of electrospinning. Gelatin was considered as base component and was associated to low and high molecular weight chitosans and alginate. The scaffolds were characterized by chemico–physical properties (morphology, solid state-FTIR and differential scanning calorimetry (DSC)-surface zeta potential and contact angle), and mechanical properties. Moreover, preclinical properties (cytocompatibility, fibroblast and osteoblast adhesion and proliferation and antimicrobial properties) were assessed. All the scaffolds were based on cylindrical and smooth nanofibers and preserved their nanofibrous structure upon hydration independently of their composition. They possessed a high degree of hydrophilicity and negative zeta potentials in a physiological environment, suitable surface properties to enhance cell adhesion and proliferation and to inhibit bacteria attachment. The scaffold based on gelatin and low molecular weight chitosan proved to be effective in vitro to support both fibroblasts and osteoblasts adhesion and proliferation and to impair the proliferation of Streptococcus mutans and Aggregatibacter actinomycetemcomitans, both pathogens involved in periodontitis.
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Sun, Zhenghua, Hao Xiong, Tengfei Lou, et al. "Multifunctional Extracellular Matrix Hydrogel with Self-Healing Properties and Promoting Angiogenesis as an Immunoregulation Platform for Diabetic Wound Healing." Gels 9, no. 5 (2023): 381. http://dx.doi.org/10.3390/gels9050381.
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Treating chronic wounds is a global challenge. In diabetes mellitus cases, long-time and excess inflammatory responses at the injury site may delay the healing of intractable wounds. Macrophage polarization (M1/M2 types) can be closely associated with inflammatory factor generation during wound healing. Quercetin (QCT) is an efficient agent against oxidation and fibrosis that promotes wound healing. It can also inhibit inflammatory responses by regulating M1-to-M2 macrophage polarization. However, its limited solubility, low bioavailability, and hydrophobicity are the main issues restricting its applicability in wound healing. The small intestinal submucosa (SIS) has also been widely studied for treating acute/chronic wounds. It is also being extensively researched as a suitable carrier for tissue regeneration. As an extracellular matrix, SIS can support angiogenesis, cell migration, and proliferation, offering growth factors involved in tissue formation signaling and assisting wound healing. We developed a series of promising biosafe novel diabetic wound repair hydrogel wound dressings with several effects, including self-healing properties, water absorption, and immunomodulatory effects. A full-thickness wound diabetic rat model was constructed for in vivo assessment of QCT@SIS hydrogel, in which hydrogels achieved a markedly increased wound repair rate. Their effect was determined by the promotion of the wound healing process, the thickness of granulation tissue, vascularization, and macrophage polarization during wound healing. At the same time, we injected the hydrogel subcutaneously into healthy rats to perform histological analyses of sections of the heart, spleen, liver, kidney, and lung. We then tested the biochemical index levels in serum to determine the biological safety of the QCT@SIS hydrogel. In this study, the developed SIS showed convergence of biological, mechanical, and wound-healing capabilities. Here, we focused on constructing a self-healing, water-absorbable, immunomodulatory, and biocompatible hydrogel as a synergistic treatment paradigm for diabetic wounds by gelling the SIS and loading QCT for slow drug release.
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Hosseinkhani, Ayda, Maryam Falahatzadeh, Elahe Raoofi, and Mohammad M. Zarshenas. "An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 2 (2016): 334–43. http://dx.doi.org/10.1177/2156587216654773.
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Research on wound healing agents is a developing area in biomedical sciences. Traditional Persian medicine is one of holistic systems of medicine providing valuable information on natural remedies. To collect the evidences for wound-healing medicaments from traditional Persian medicine sources, 5 main pharmaceutical manuscripts in addition to related contemporary reports from Scopus, PubMed, and ScienceDirect were studied. The underlying mechanisms were also saved and discussed. Totally, 65 herbs used in traditional Persian medicine for their wound healing properties was identified. Related anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities of those remedies were studied. Forty remedies had at least one of those properties and 10 of the filtered plants possessed all effects. The medicinal plants used in wound healing treatment in traditional Persian medicine could be a good topic for further in vivo and clinical research. This might lead to development of effective products for wound treatment.
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Oprita, Elena Iulia, Andreea Iosageanu, and Oana Craciunescu. "Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing." Gels 9, no. 11 (2023): 867. http://dx.doi.org/10.3390/gels9110867.
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Diabetes is a condition correlated with a high number of diagnosed chronic wounds as a result of a complex pathophysiological mechanism. Diabetic chronic wounds are characterized by disorganized and longer stages, compared to normal wound healing. Natural polymer hydrogels can act as good wound dressings due to their versatile physicochemical properties, represented mainly by high water content and good biocompatibility. Natural bioactive hydrogels are polymers loaded with bioactive compounds providing antibacterial and antioxidant properties, modulation of inflammation and adherence to wounded tissue, compared to traditional dressings, which enables promising future applications for diabetic wound healing. Natural bioactive compounds, such as polyphenols, polysaccharides and proteins have great advantages in promoting chronic wound healing in diabetes due to their antioxidant, anti-inflammatory, antimicrobial, anti-allergic and wound healing properties. The present paper aims to review the wound healing mechanisms underlining the main issues of chronic wounds and those specifically occurring in diabetes. Also, the review highlights the recent state of the art related to the effect of hydrogels enriched with natural bioactive compounds developed as biocompatible functional materials for improving diabetic-related chronic wound healing and providing novel therapeutic strategies that could prevent limb amputation and increase the quality of life in diabetic patients.
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Al-Gharbawi, Hussein Shundi Alhajj, Marwan Saleh Mahdi, Mustafa Naeem Nuhair Al-sarray, and Sajjad Jawad Kadhi Al-sarray. "Antibacterial activity and wound healing properties of chitosan ana nanoparticle chitosan in rat." Experimental and Theoretical NANOTECHNOLOGY 9, S (2025): 27–38. https://doi.org/10.56053/9.s.27.
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This study investigates the antibacterial and wound healing properties of chitosan and chitosan nanoparticles in a rat model. Twenty adult male rats are divided into two groups: one group received chitosan treatment, and the other received chitosan nanoparticle treatment. Each rat had two skin slits, which are dried over seven days. Wound healing is estimated through histopathological and microbiological duties. The findings tell that chitosan nanoparticles significantly develop wound healing and exhibit bigger antibacterial activity compared to traditional chitosan, representing their potential for innovative wound care applications.
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Kasouni, Athanasia I., Theodoros G. Chatzimitakos, Constantine D. Stalikas, Theoni Trangas, Alexandra Papoudou-Bai, and Anastassios N. Troganis. "The Unexplored Wound Healing Activity of Urtica dioica L. Extract: An In Vitro and In Vivo Study." Molecules 26, no. 20 (2021): 6248. http://dx.doi.org/10.3390/molecules26206248.
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Wound healing is a great challenge in many health conditions, especially in non-healing conditions. The search for new wound healing agents continues unabated, as the use of growth factors is accompanied by several limitations. Medicinal plants have been used for a long time in would healing, despite the lack of scientific evidence veryfying their efficacy. Up to now, the number of reports about medicinal plants with wound healing properties is limited. Urtica dioica L. is a well-known plant, widely used in many applications. Reports regarding its wound healing potential are scant and sparse. In this study, the effect of an Urtica dioica L. extract (containing fewer antioxidant compounds compared to methanolic or hydroalcoholic extracts) on cell proliferation, the cell cycle, and migration were examined. Additionally, antioxidant and anti-inflammatory properties were examined. Finally, in vivo experiments were carried out on full-thickness wounds on Wistar rats. It was found that the extract increases the proliferation rate of HEK-293 and HaCaT cells up to 39% and 30% after 24 h, respectively, compared to control cells. The extract was found to increase the population of cells in the G2/M phase by almost 10%. Additionally, the extract caused a two-fold increase in the cell migration rate of both cell lines compared to control cells. Moreover, the extract was found to have anti-inflammatory properties and moderate antioxidant properties that augment its overall wound healing potential. Results from the in vivo experiments showed that wounds treated with an ointment of the extract healed in 9 days, while wounds not treated with the extract healed in 13 days. Histopathological examination of the wound tissue revealed, among other findings, that inflammation was significantly reduced compared to the control. Urtica dioica L. extract application results in faster wound healing, making the extract ideal for wound healing applications and a novel drug candidate for wound healing.
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Allu, Ishita, Ajay Kumar Sahi, Pooja Kumari, Karunya Sakhile, Alina Sionkowska, and Shravanya Gundu. "A Brief Review on Cerium Oxide (CeO2NPs)-Based Scaffolds: Recent Advances in Wound Healing Applications." Micromachines 14, no. 4 (2023): 865. http://dx.doi.org/10.3390/mi14040865.
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The process of wound healing is complex and involves the interaction of multiple cells, each with a distinct role in the inflammatory, proliferative, and remodeling phases. Chronic, nonhealing wounds may result from reduced fibroblast proliferation, angiogenesis, and cellular immunity, often associated with diabetes, hypertension, vascular deficits, immunological inadequacies, and chronic renal disease. Various strategies and methodologies have been explored to develop nanomaterials for wound-healing treatment. Several nanoparticles such as gold, silver, cerium oxide and zinc possess antibacterial properties, stability, and a high surface area that promotes efficient wound healing. In this review article, we investigate the effectiveness of cerium oxide nanoparticles (CeO2NPs) in wound healing—particularly the effects of reducing inflammation, enhancing hemostasis and proliferation, and scavenging reactive oxygen species. The mechanism enables CeO2NPs to reduce inflammation, modulate the immunological system, and promote angiogenesis and tissue regeneration. In addition, we investigate the efficacy of cerium oxide-based scaffolds in various wound-healing applications for creating a favorable wound-healing environment. Cerium oxide nanoparticles (CeO2NPs) exhibit antioxidant, anti-inflammatory, and regenerative characteristics, enabling them to be ideal wound healing material. Investigations have shown that CeO2NPs can stimulate wound closure, tissue regeneration, and scar reduction. CeO2NPs may also reduce bacterial infections and boost wound-site immunity. However, additional study is needed to determine the safety and efficacy of CeO2NPs in wound healing and their long-term impacts on human health and the environment. The review reveals that CeO2NPs have promising wound-healing properties, but further study is needed to understand their mechanisms of action and ensure their safety and efficacy.
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Jain, UK, and Nilesh Gupta. "Prominent wound healing properties of indigenous medicines." Journal of Natural Pharmaceuticals 1, no. 1 (2010): 2. http://dx.doi.org/10.4103/2229-5119.73579.
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Antonov, S. F., E. V. Kryzhanovskaya, Yu I. Filippov, S. M. Shinkarev, and M. A. Frolova. "Study of wound-healing properties of chitosan." Russian Agricultural Sciences 34, no. 6 (2008): 426–27. http://dx.doi.org/10.3103/s1068367408060190.
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Mohamed, Seema, Mary D. Nadijcka, and Victor A. Hanson. "Wound Healing Properties of Cimetidine in Vitro." Drug Intelligence & Clinical Pharmacy 20, no. 12 (1986): 973–75. http://dx.doi.org/10.1177/106002808602001212.
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Cimetidine was one of a variety of drugs frequently given to surgical patients perioperatively tested for their effect on gap closure of wounded monolayers of human fascia cells in vitro. Cimetidine-treated cultures closed faster and had greater cell proliferation than controls. Closure of cimetidine-treated cultures occurred at six hours compared to ten hours in controls. Cimetidine concentrations of 1000 μg/ml resulted in 13.5 ± 0.67 (SEM) × 104 cells/cm2 at six hours compared to 7.9 ± 0.48 times 104 cells/cm2 in controls (p<0.05); the area covered by cells was 6.5 ± 0.02 mm2 in treated cultures compared to 3.0 ± 0.01 mm2 in controls (p<0.05). It is concluded that cimetidine stimulates fibroblast proliferation in vitro.
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Sheidu, Azeez Raji, Abdulkadir Umar Zezi, Abubakar Ahmed, Ben Ahmed Chindo, and Garba Mohammed Magaji. "Antimicrobial and wound healing properties of the methanol extract of Ficus platyphylla Del. (Moraceae) stem bark." Journal of Pharmacy & Bioresources 17, no. 2 (2021): 121–30. http://dx.doi.org/10.4314/jpb.v17i2.6.
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Ficus platyphylla (Fp) has been used in Nigerian traditional medicine for the management of pain, ulcer, wound, epilepsy and inflammation. The efficacy of its gum from the stem bark for the management of wound has been widely acclaimed among the Hausa communities of Northern Nigeria and therefore, this study was aimed at examining the antimicrobial and wound healing potential of methanol extract of F. platyphylla stem bark (MEFpSB) in order to provide scientific basis for its antimicrobial and wound healing properties. Preliminary phytochemical screening was done and antimicrobial activity using some pathogenic micro-organisms were evaluated following its wound healing effectiveness in Wistar rats using the model of superficial skin excision wound. Data were analysed using one-way analysis of variance (ANOVA) followed by Dunnet’s t-test. The results of preliminary phytochemical screeningrevealed the presence of carbohydrate, cardiac glycosides, saponins, flavonoids, triterpenes, tannins, alkaloids with anthraquinones absent. The extract showed antimicrobial activity on Staphylococcus aureus, Corynebacterium ulcerans, Escherichia coli, Klebsiella pneumonia and Salmonella typhi and significant (p< 0.05, p< 0.001) decrease in wound measurement for 11 days. This study demonstrated that MEFpSB possesses antimicrobial activity with wound healing properties that justifies the ethno-medicinal use of the plant in wound/ulcer healings.
 Keywords: Wound healing; Antimicrobial; Ficus platyphylla; Formulation; Topical
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Dospra, Maria, Panagoula Pavlou, Spyridon Papageorgiou, and Athanasia Varvaresou. "Recent Studies on the Healing Properties of Eicosapentaenoic Acid." Applied Sciences 14, no. 13 (2024): 5884. http://dx.doi.org/10.3390/app14135884.
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Patients with diabetes, the elderly, and those who have certain inherited conditions are particularly vulnerable to atypical wound healing with lingering repercussions. Remarkably, the current remedies are insufficient since, despite the plethora of wound healing options, only limited efficacy is observed. This review is a bibliographic survey on eicosapentaenoic acid and its healing effects. It has been investigated in terms of its source of origin, structure, physico-chemical properties, and studies where healing action is demonstrated. Fatty acids, found in all layers of the skin, modify cell function and the synthesis of eicosanoids, reactive oxygen species, and cytokines, which affects skin structure and immunological condition. As a result, fatty acids influence both the inflammatory response and the wound-healing process. EPA is one of the dietary lipids that has a variety of health advantages. It functions in anti-inflammatory processes and the firmness of cell membranes and is integrated into numerous bodily parts. EPA has a crucial role in healthy fetal development and aging. It is a precursor to numerous metabolites that are powerful lipid mediators and are regarded by many researchers as being helpful in the treatment or prevention of several disorders. EPA supplement is used after surgery to lessen infections, accelerate wound healing, and speed up recovery, although, according to other researchers, the oral administration of omega-3 fatty acids, particularly the DHA and EPA combination, significantly slows down the healing of wounds and disrupts the structure of collagen through several mechanisms. The controversy in the reported literature is discussed and new technologies useful for the improvement of the wound healing process are also reported.
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Alven, Sibusiso, Buhle Buyana, Zizo Feketshane, and Blessing Atim Aderibigbe. "Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials." Pharmaceutics 13, no. 7 (2021): 964. http://dx.doi.org/10.3390/pharmaceutics13070964.
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The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing.
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Sallehuddin, Nusaibah, Abid Nordin, Ruszymah Bt Hj Idrus, and Mh Busra Fauzi. "Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review." International Journal of Environmental Research and Public Health 17, no. 11 (2020): 4160. http://dx.doi.org/10.3390/ijerph17114160.
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Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.
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Yusmin, Ahmadi, and Norhayati Ahmad. "EFFECT OF THYMOQUINONE ON WOUND HEALING IN ALLOXAN-INDUCED DIABETIC RATS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 242. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.18951.
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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented.Methods: In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats.Conclusions: Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.
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Kannan, Madhumita, R. Kalpana, and Vinay Kumar. "Sodium Alginate Chitosan Crosslinked Hydrogel Amoxycillin Absorption Properties." Journal of Pharmacy and Bioallied Sciences 16, Suppl 2 (2024): S1161—S1163. http://dx.doi.org/10.4103/jpbs.jpbs_511_23.
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ABSTRACT Wound healing refers to the replacement of destroyed or damaged tissue of a living organism by newly produced tissue, and the time taken is known as wound regeneration time. Wound care is a major challenging biomedical field due to the delayed healing process or delayed wound regeneration time. The factors responsible for delayed wound healing are poor oxygen flow, less exposure to moisture, diseases such as diabetes and cancer, etc., Wound dressings that are formulated from biopolymers such as chitosan, chitin, and cellulose have properties such as biocompatibility (compatible with living systems and does not cause any immunological rejection), biodegradable, nontoxic with minimal side effects, anti-microbial, anti-inflammatory properties. Chitosan is obtained from scales of fish and shrimp. It contains highly reactive amine groups and sodium alginate, which is a polysaccharide produced from seaweed and bacteria and is biocompatible with living systems and biodegradable polysaccharides. This study is based on the development of sodium alginate crosslinked hydrogel and testing the properties of hydrogel with amoxycillin drug and water release property of the drug.
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Ju, Jaewon, Jungwoo Kim, Yeonsun Choi, et al. "Punicalagin-Loaded Alginate/Chitosan-Gallol Hydrogels for Efficient Wound Repair and Hemostasis." Polymers 14, no. 16 (2022): 3248. http://dx.doi.org/10.3390/polym14163248.
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For recently devised wound-healing materials, a variety of acute application systems with sustainable therapeutic effects on wound sites have been suggested. For example, hydrogel-type healing agents with porous structures and high drug encapsulation efficiencies have been developed for wound repair. However, challenges remain about the poor mechanical and adhesive properties of hydrogels. Herein, we propose a punicalagin (PC)-containing wound-healing hydrogel in adhesive form that is mechanically stable and has sustainable wound-healing therapeutic efficiency. The APC hydrogel, composed of alginate (ALG), PC, and chitosan–gallol (CHI–G), exhibits significant mechanical and self-healing properties, thus indicating that PC increases cross-linking in ALG/CHI–G as macromolecule. The PC-containing mechanically enhanced hydrogel demonstrates high tissue adhesiveness. Sustainable PC release for 192 h, which indicates high therapeutic effect of the released PC, and great blood compatibility are evaluated based on rapid blood coagulation and minimal hemolysis. The cytocompatibility and wound-healing abilities of the PC-containing APC hydrogel are greater than those of the non-PC hydrogel, as verified by cell compatibility and wound scratch assays. These results indicate that a suitable concentration of PC-containing hydrogel with sustainable moisture condition and PC release may inspire further polyphenol-agent-containing hydrogels as wound-healing agents with structural stability and therapeutic efficiency.