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Rozprawy doktorskie na temat „Angiotensin-1 converting enzyme”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Sprawdź 21 najlepszych rozpraw doktorskich naukowych na temat „Angiotensin-1 converting enzyme”.

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1

Hocharoen, Lalintip. "Catalytic Metallopeptide Promoted Inactivation of Enzyme Targets Related to Disease: Angiotensin Converting Enzyme-1 and SortaseA." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354634371.

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Serfözö, Peter Daniel [Verfasser]. "Angiotensin-Converting Enzyme 2- and Prolyl Carboxypeptidase-Independent Conversion of Angiotensin II to Angiotensin-(1-7) in Circulation and Peripheral Tissues / Peter Daniel Serfözö." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1218076844/34.

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Dean, Stephanie A. "Regulation of angiotensin converting enzyme and angiotensin II type 1 receptor by 17beta-estradiol in female rats: Implications following experimental myocardial infarction." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26883.

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The present studies tested the hypothesis that 17beta-estradiol (E2) downregulates ACE and AT1R in several tissues important to cardiovascular regulation, including the brain and heart, and that this downregulation attenuates the progression of LV dysfunction following myocardial infarction (MI). In Experiment 1, female Wistar rats were randomized into one of four groups: (1) sham-ovariectomized (OVX); (2) OVX+vehicle (veh); (3) OVX+E2 replacement at physiological levels and (4) OVX+high E2. Five weeks following OVX, ACE and ATIR were increased 15-90% in the heart, several cardiovascular nucle

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Chisi, John Eugenes. "The regulatory role of AcSDKP and angiotensin 1-converting enzyme (ACE) inhibitors on haematopoietic stem and progenitor cell proliferation." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14971.

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Negative regulatory factors inhibit the proliferation of haematopoietic stem cells thus protecting them from differentiation pressures. One of the negative regulators of stem cell proliferation is the tetrapeptide Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP). This peptide is endogenously produced in vivo and long term bone marrow cultures and is degraded by angiotensin 1-converting enzyme (ACE) both in vivo and in vitro. The aim of these investigations was to study the role of ACE on haematopoietic stem and progenitor cell proliferation. Since the N-domain ACE active has been implicated in AcS

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5

Wang, Yu. "THE ROLE OF THE ACE2/ANG-(1-7)/MASR AXIS IN THE DEVELOPMENT OF OBESITY-HYPERTENSION IN MALE AND FEMALE MICE." UKnowledge, 2016. http://uknowledge.uky.edu/pharmacol_etds/13.

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Obesity is strongly associated with hypertension and cardiovascular diseases. An activated renin-angiotensin system (RAS) has long been suggested as a critical contributor to elevated blood pressure with obesity. Angiotensin II (AngII), the main effector of an activated RAS, can be catabolized by angiotensin-converting enzyme 2 (ACE2) to form angiotensin-(1-7) (Ang-(1-7)), which, acting through the mas receptor (MasR), has been shown to oppose the effects of an activated RAS. Therefore, further understanding of the mechanisms of this counter-regulatory arm, called the ACE2/Ang-(1-7)/MasR axis,

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6

Raji, Ismaila. "Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive wistar rats." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5212_1367481132.

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<p>Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this&nbsp<br>herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study&nbsp<br>was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats<br>&nbsp<br>and to find out the mechanism(s) by whic

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7

Glover, Zoe. "Acer, a homologue of the human angiotensin-1 converting enzyme, modulates the response of sleep, glycogen storage, lifespan, fecundity and stress resistance to diet in Drosophila melanogaster." Thesis, Lancaster University, 2017. http://eprints.lancs.ac.uk/86909/.

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Human angiotensin-1–converting-enzyme (ACE) plays a primary role in the regulation of blood pressure and electrolytes as part of the Renin-Angiotensin System (RAS) in humans. Renin cleaves angiotensinogen to angiotensin I and ACE regulates the vasoconstriction of blood vessels by converting angiotensin-1 to angiotensin-2 (a potent vasoconstrictor) and also by breaking down bradykinin (a potent vasodilator). Renin is regulated by a feedback loop mechanism and is inhibited by higher concentrations of angiotensin-2. A lack of or inhibition of ACE can lead to a reduction in blood pressure (BP) and

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8

Cobas, Roberta Arnoldi. "Polimorfismo I/D do gene da enzima conversora de angiotensina e C242T do gene do componente p22phox da NADPH oxidase em pacientes com diabetes tipo 1." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1694.

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O sistema renina-angiotensina e o estresse oxidativo têm participação importante na fisiopatologia das complicações crônicas do diabetes. No presente estudo, foram avaliados 103 pacientes com diabetes tipo 1 (DM1) com idade de 28,810,6 anos e duração de doença de 13,18,5 anos e 158 controles não diabéticos quanto à presença dos polimorfismos I/D da ECA e C242T do p22phox, componente essencial para a ativação da NADPH oxidase. Esta análise foi realizada por reação de polimerase em cadeia para ambos os polimorfismos, seguida de restrição enzimática para avaliação do polimorfismo C242T p22phox.

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9

Al, Bacha Jeanne D'Arc. "Nouvelles fonctions de l'enzyme de conversion de l'angiotensine et du récepteur de la (pro)rénine en pathologies cardiovasculaires et neurologiques." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066415.

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De nouveaux composants du système rénine angiotensine (SRA) continuent d'être découverts et leurs fonctions étudiées. Cette thèse présente de nouvelles relations entre enzyme de conversion de l’angiotensine (ECA), thrombose et maladies cardiovasculaires (MCV), d’une part, et d’autre part, un rôle pour le récepteur de la (pro)rénine dans le développement du système nerveux central (SNC). Tout d’abord, nous avons étudié l'association de la double mutation de l’ECA et l’inhibiteur de l’activateur du plasminogène-1 (PAI-1) sur l’incidence d’évènements cardiovasculaires chez les patients Libanais h

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10

Wiklund, Per-Gunnar. "Genetic aspects of stroke : association and linkage studies in a northern Swedish population." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-668.

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11

Samnegård, Björn. "Renal effects of C-peptide in experimental type-1 diabetes mellitus /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-502-X/.

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12

Wang, Peiyu. "Strategy and molecular mechanism study of cold atmospheric plasma applications in oncotherapy, virucide and nanotechnology." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/214016/1/Peiyu_Wang_Thesis.pdf.

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This thesis is the study of cold atmospheric plasma (CAP) applications in cancer, anti-viral treatments, and nano-biotechnology. The optimal treatment strategy, potential molecular mechanism and methods to increase selectivity and efficiency of plasma treatment were investigated for each application. In the near future, CAP or plasma activated medium (PAM) would likely become a widely used, high-efficiency and targeted clinical therapeutic tool.

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13

"The angiotensin converting enzyme 2 - angiotensin (1-7) axis protects endothelial function against oxidative stress in diabetes." 2013. http://library.cuhk.edu.hk/record=b5884510.

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Zhang, Yang.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 147-169).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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14

Wen, Cheng-Hao, and 溫証皓. "Interplay of Angiotensin II and Angiotensin 1-7 in the Modulation of Cardiac Angiotensin-Converting Enzyme II of Human Cardiofibroblasts." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/80516546561355121015.

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碩士<br>國立交通大學<br>生物科技系所<br>97<br>Components of renin–angiotensin system (RAS) are well established targets for pharmacological intervention in a variety of disorders. Many such therapies abrogate the effects of the hypertensive and mitogenic peptide, angiotensin II (Ang II), by antagonising its interaction with its receptor, or by inhibiting its formative enzyme, angiotensin-converting enzyme (ACE). At the turn of the millennium, a novel homologous enzyme, termed ACE2, was identified which increasingly shares the limelight with its better-known homologue. In common with ACE, ACE2 is a type I

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15

Liu, George. "Studies on Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and p47phox-Dependent NADPH Oxidase and their Roles in Diabetic Nephropathy." Thesis, 2012. http://hdl.handle.net/1807/34787.

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Diabetic nephropathy is the leading cause of end-stage renal disease, yet the mechanisms responsible for hyperglycemia-induced kidney injury have not been fully elucidated. Activation of the renin-angiotensin system and NADPH oxidase-dependent generation of reactive oxygen species are important mediators of chronic kidney disease. I first studied the effect of ACE2, an important enzyme in the renin-angiotensin system, in diabetic kidney injury in the Akita mouse and related the effect to angiotensin peptide and NADPH oxidase. I then demonstrated the interaction between Angiotensin II, the main

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16

Pei-Chun, Hsieh, and 謝佩君. "Association study between hypertension and polymorphisms of angiotensinogen, angiotensin-1 converting enzyme, and lipoprotein lipase genes in Taiwanese." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/45186786515950632452.

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碩士<br>國立臺灣大學<br>農業化學研究所<br>89<br>Angiotensinogen (AGT) and angiotensin-I converting enzyme (ACE) play important roles in controlling blood pressure. Nevertheless, studies in various ethnic groups have shown contradictory results on the association between hypertension and genotype of ACE I/D, AGT M235T and T174M polymorphism. Two microsatellite markers, ATA108a05 and LPL, have been linked to young-onset hyperetension in Taiwan. Using 456 Taiwanese subjects that were randomly selected from the general population (the Nutrition and Health Survey in Taiwan, 1993-1996), we examined the association

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17

Hsu, Wei-Chieh, and 許為捷. "Angiotensin Converting Enzyme Inhibitory Activity and the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) Radical-Scavenging Effect of Various Koji Mold-fermented Black Soybeans." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/03795707061477793224.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>99<br>In this study, black soybeans were fermented with Aspergillus oryzae BCRC 30222, A. sojae BCRC 30103 or Monascus pilosus BCRC 31526 at 30oC and 95% relative humidity for 6 days. The Angiotensin converting enzyme (ACE) inhibitory effect and 2,2-diphenyl -1-picrylhydrazyl (DPPH) radical-scavenging effect exerted by the various fermented black soybeans were then investigated. Besides, the degree of protein hydrolysis, total phenolics, flavonoids and anthocyanin contents of the fermented black soybeans were examined.Results revealed that fermentation, regardless of

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18

Ali, Ismael Mahmoud. "Cardiovascular and sensory abnormalities in a rat model of insulin resistance : beneficial effect of an antioxidant and an angiotensin-1 converting enzyme inhibitor." Thèse, 2007. http://hdl.handle.net/1866/8204.

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19

Cabrita, Brigite Ladeira. "Characterization and modulation of the Renin-Angiotensin System in Diabetic Retinopathy." Master's thesis, 2019. http://hdl.handle.net/10362/89766.

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Diabetes mellitus is a chronic disease whose numbers of affected individuals are substantially increasing. Diabetes-associated complications include Diabetic Retinopathy (DR), the main cause of visual impairment and blindness. DR is a progressive pathology affecting the retina, caused by chronic hyperglycaemia. From the several associated risk factors, hypertension has been considered a key player in DR. Renin-Angiotensin System (RAS) is the hormonal cascade responsible for the control of blood pressure. This system can be divided in two main axes: a deleterious one that promotes vasoconstrict

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20

Shi, Yixuan. "Caractérisation du gène de l'enzyme de conversion de l'angiotensine-2 dans le rein diabétique et implication dans le développement de la néphropathie diabétique et de l'hypertension." Thèse, 2014. http://hdl.handle.net/1866/11828.

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De nombreuses études ont bien démontré que l’activation du système rénine-angiotensine (RAS) joue un rôle important dans le développement de l’hypertension et de la néphropathie diabétique (DN). La découverte de l’enzyme de conversion de l’angiotensine-2 (ACE2) et l’identification du récepteur MAS, spécifique pour l’angiotensine 1-7 (Ang 1-7), ont permis d’identifier deux nouveaux membres du RAS. L’axe ACE2/Ang 1-7/MAS contrebalance les effets de l’axe ACE/Ang II/AT1. Plusieurs évidences impliquent la contribution du RAS intrarénal dans la DN. Des études réalisées dans notre laboratoire avec d

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21

Heller, Samuel. "Aldosteron syntáza u arteriální hypertenze a možný vliv polymorfismu jejího genu na hypertrofii levé komory srdeční." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-326710.

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Part I. The aldosterone synthase gene (CYP11B2) polymorphism T-344C in blood pressure and left ventricular hypertrophy. BACKGROUND: Aldosterone is a key cardovascular hormone, it significantly influences volume, pressure and electrolyte balance. Aldosterone plays an important role in development of left ventricular (LV) hypertrophy and myocardial fibrosis. The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. DESIGN AND METHODS: We assessed the influence of the T-344C polymorphism of aldosterone synthase - the rate-limiting enzyme in aldostero

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