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Rozprawy doktorskie na temat „Angiotensin Inhibitors”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Hughes, M. A. "Metal binding by some angiotensin converting enzyme inhibitors." Thesis, Cardiff University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305894.

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2

Dičkutė, Asta. "Trends in the use of Angiotensin converting enzyme inhibitors and Angiotensin II antagonists in Lithuania on 2005-2007 years." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080616_100311-96511.

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Objective: To evaluate the tendencies of utilization of Angiotensin converting enzyme inhibitors and Angiotensin II receptors antagonists in Lithuania during 2005-2007 years. Methods: MEDLINE database was searched to identify and evaluate all literature relating to pharmacokinetic and pharmacodynamic characteristics of Angiotensin converting enzyme inhibitors and Angiotensin II antagonists. Utilization data of Angiotensin converting enzyme inhibitors (plain and combinations) and Angiotensin II antagonists (plain and combinations) in Lithuania over three years (2005 – 2007) period were obtaine

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3

Brice, Edmund Andrew William. "Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27042.

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The renin-angiotensin system plays a central role in the maintenance of blood pressure. Angiotensin II, the main effector of this system, results from the action of angiotensin-converting enzyme (ACE) on angiotensin I. Angiotensin II, maintains vasomotor tone via its vasoconstrictor action, and also increases salt and water retention by stimulating the release of aldosterone. ACE inhibitors, such as captopril, enalapril and lisinopril, are highly effective in the treatment of hypertension and congestive cardiac failure. Previous studies have suggested that angiotensin converting enzyme (ACE) p

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4

Coltart, Donald M. "Synthetic studies on angiotensin-converting enzyme inhibitors, pyridines, and peptides." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0014/NQ59572.pdf.

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5

Longman, S. D. "Cardiovascular studies with angiotensin converting enzyme inhibitors in the rat." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375102.

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6

Ajayi, A. A. L. "Clinical and pharmacological studies on angiotensin-I-converting enzyme inhibitors." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374510.

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7

Christian, Jennifer B. "Beyond the antihypertensive effect: ACE inhibitors and angiotensin receptor blockers." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318302.

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8

Lee, Alison Frances Clare. "The renin angiotensin aldosterone axis : relationships with other hormone systems, and novel applications for angiotensin converting enzyme inhibitors." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22401.

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The aim of this thesis was to look at the renin angiotensin system both in clinical heart failure, and in relation to other physiological systems where an interaction may exist. Furthermore, to address new areas where a potential for benefit with Angiotensin Converting Enzyme (ACE) inhibitors might occur. To this end there are five studies discussed within the thesis. It is shown that in a group of heart failure patients, stabilised on maximum tolerated dose of ACE inhibitor, mean levels of plasma neurohormones were remarkably stable over 18 months. Reactivation of aldosterone occurred in 13/9

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9

Chadwick, Ian George. "Studies on the angiotensin converting enzyme gene polymorphism and ACE inhibitors." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21136.

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Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism accounts for 47% of the variability in serum ACE concentrations between subjects but its relevance to tissue ACE is unknown. ACE inhibition increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in t

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10

Titus, Timothy. "Utilization of Angiotensin-Converting-Enzyme Inhibitors in the Treatment of Diabetics Within an Out-Patient Care Facility." The University of Arizona, 2005. http://hdl.handle.net/10150/624773.

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Class of 2005 Abstract<br>Objective: The purpose of this study was to retrospectively determine if individuals within the SAVAHCS home-based patient population with a diagnosis of diabetes mellitus are receiving an angiotensin-converting-enzyme inhibitor (ACE-I) based on recent evidence supporting its use in these patients. Research Design: A retrospective, chart review of 41 patients with a diagnosis of diabetes mellitus from November 1, 2004 to December 31, 2005. Methodology: This was a retrospective, chart review of all patients within the SAVAHCS home-based population with an active diag

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11

Schmid, Ursula. "Protection against oxidative DNA damage by antioxidants, hormone-receptor blockers and HMG-CoA-reductase inhibitors." Doctoral thesis, kostenfrei, 2008. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-.

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12

Mielke, Marilyn. "Mechanisms underlying the inotropic response to angiotensin II in the heart." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325976.

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13

Hagemann, Diana. "Tryptophanhaltige Dipeptide als Hemmstoffe für das Angiotensin-Converting Enzyme." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-223528.

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Bluthochdruck zählt zu einer der häufigsten Zivilisationskrankheiten und ist der Hauptfaktor für die Entstehung kardiovaskulärer Erkrankungen. Das Präventionspotenzial bei Hypertonie ist sehr hoch, da lebensstilassoziierte Faktoren wie Übergewicht, hoher Kochsalz- und Alkoholkonsum oder Stress die Entstehung eines erhöhten Blutdrucks wesentlich begünstigen. Daher wird eine antihypertensive Therapie meist mit nicht-medikamentösen Maßnahmen eingeleitet. Für die Regulation des Blutdrucks ist die nähere Betrachtung des Angiotensin-Converting Enzymes (ACE) wichtig, da es eines der Schlüsselenzyme d

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14

Beaton, Nigel Alexander. "Inhibition of collagenase by the angiotensin-converting enzyme inhibitors captopril & enalapril." Thesis, University of Strathclyde, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502348.

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Collagen scaffolds provide a biocompatible matrix within tissue engineering and have already found many clinical uses. Two key requirements are that they are biologically Stable and mechanically strong. However, once seeded with cells or implanted in vivo collagen scaffolds are constantly being degraded and rebuilt. The balance of these two processes determines the matrix integrity. Studies have found that excessive degradation leads to mechanically weak matrices. The collagenases, members of the matrix metalloproteinase (MMP) family, play a vital role in matrix degradation. Collagenase inhibi

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15

Rodrigues, Eric John. "The effect of angiotensin-converting enzyme inhibitors on mortality following acute myocardial infarction /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33832.

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Many angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce mortality after acute myocardial infarction (AMI), yet no study has investigated if this is a class effect. Discharge prescription data were analyzed for patients ≥65 years old hospitalized for AMI in Quebec between 1996 and 1998. Among those prescribed an ACE inhibitor (n = 6,287), the association between the specific drug prescribed and mortality following AMI was studied using Cox proportional-hazards models. A propensity score analysis compared short-acting with long-acting ACE inhibitors to account for confoundi

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16

Monaco, Dominick, Jose Romero, and Jesus Solis. "A Comprehensive Literature Review of Non-‐cough Adverse Drug Reactions (ADRs) Associated With Angiotensin." The University of Arizona, 2010. http://hdl.handle.net/10150/623789.

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Class of 2010 Abstract<br>OBJECTIVES: To comprehensively review medical literature and report angiotension converting enzyme inhibitors (ACE-‐I) adverse drug reactions including, incidences, mechanism of action, predisposing conditions, and report prevention and treatments. METHODS: This was a descriptive retrospective study of data related to ACE-‐I adverse drug reactions other than ACE-‐I induced cough. It was to review the ADR that accompany with the use of ACE-‐I. Literature obtained through search engines MEDLINE and OVID SP available through the Arizona Health and Science Library at

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17

Broek, Stanislaus Antonius Jacobus van den. "Angiotensin-converting enzyme inhibitors in heart failure clinical end points to assess therapeutic efficacy /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1994. http://irs.ub.rug.nl/ppn/293017212.

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18

Kondowe, Greeves Burton Chianira. "An investigation of some of the mechanisms of action of angiotensin converting enzyme inhibitors." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254326.

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19

Fenning, Andrew S. "Cardiac remodelling in rat models of chronic cardiovascular disease : angiotensin-converting enzyme inhibition in heart failure and diabetes /." [St. Lucia, Qld], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18264.pdf.

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20

Watermeyer, Jean Margaret. "Structural determinants of the domain-selectivity of novel inhibitors of human testis angiotensin-converting enzyme." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3154.

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21

Clayton-Warnes, Lisa J. "Oxidative stress and the glomerulus: influence of prostanoids, angiotensin converting enzyme inhibitors and iron chelation." Thesis, Keele University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484159.

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22

Ho, Kwun-wai, and 何冠威. "Angiotensin converting enzyme inhibitor alone or in combination with angiotensin II type I receptor blocker in patients with chronicproteinuric nephropathies: a systemic reviewof clinical trials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010687.

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23

Heran, Balraj Singh. "A systematic review of the blood pressure lowering efficacy of ACE inhibitors and angiotensin receptor blockers for primary hypertension." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1448.

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Context: Although the long-term goal of antihypertensive therapy is to reduce adverse clinical outcomes, the only way to evaluate the efficacy of treatment in an individual is the magnitude of blood pressure (BP) reduction. ACE inhibitors and angiotensin receptor blockers (ARBs) are two drug classes that, by different mechanisms, inhibit the renin-angiotensin- aldosterone system that regulates BP. As these drugs are widely prescribed for hypertension, it is essential to determine and compare their effects on BP, heart rate and tolerability. Objectives: 1) To determine the dose-related effect o

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24

Ahn, Jae-Eun. "Production and characterization of angiotensin I-convertine enzyme inhibitory peptides from whey fermentation with lactic acid bacteria." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32746.

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Whey media, containing 2% (w/v) whey powder, 1% (w/v) glucose, and 0.5% (w/v) yeast extract, were fermented with nine Lactobacillus strains to produce angiotensin I-converting enzyme (ACE) inhibitory peptides. Lb. brevis, Lb. helveticus, and Lb. paracasei were most effective in producing whey hydrolysates that contained potent ACE inhibitors, with the inhibition rate ranging from 93.3 +/- 0.3 to 100%. The hydrolysates of three Lactobacillus strains were partially purified by dialysis (6,000--8,000 Da cut-off) to remove larger molecules, and subsequently subjected to RP-HPLC, equipped with a De

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25

O'Donnell, Mark John. "The kidney in diabetes mellitus : urinary transfer in excretion, hypertension, the Renin-Angiotensin-Aldosterone system, and the role of angiotensin converting enzyme inhibitors in therapy." Thesis, University of Birmingham, 1993. http://etheses.bham.ac.uk//id/eprint/37/.

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Patients with diabetic renal disease develop elevated urinary albumin excretion rates [AER] and hypertension. Preliminary data from several groups suggest that diabetic patients handle transferrin, a protein similar in size and weight, in a different fashion from albumin. In the first part of this thesis I report the results of clinical studies of urinary transferrin excretion [TER] in diabetes mellitus. More than 80% type 1 [insulin dependent] diabetic patients have increased TER but less than 40% have increased AER. TER may be provoked by exercise in uncomplicated type 1 diabetes and the ris

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26

Gisler, Fabian. "Effectiveness of angiotensin-converting enzyme inhibitors in pediatric patients with mid to severe aortic value regurgitation /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000281144.

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27

Rothmann, Lourens Johannes. "Prescribing patterns of angiotensin-converting enzyme inhibitors for the period 2001 until 2006 / Lourens Johannes Rothmann." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1946.

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28

Agalo, Faith. "Synthesis of Insulin-Regulated Aminopeptidase (IRAP) inhibitors." Thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-257559.

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The need for alternative cognitive enhancers has risen due to the fact that clinical trial results of the drugs currently approved for treating these disorders have not been satisfactory. IRAP has become a possible drug target for treating cognitive impairment brought about by Alzheimer’s disease, head trauma or cerebral ischemia, among others. This came after the revelation that Angiotensin IV enhances memory and learning. Angiotensin IV, the endogenous ligand of IRAP has been structurally modified with the aim of producing potent IRAP inhibitors. However, the peptidic nature of these inhibit

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29

殷子敬 and Tsz-king Eric Yan. "Studies on food-derived antihypertensive peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3122541X.

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30

Lanthier, Christopher Michael. "The inhibition of carboxypeptidase A and angiotensin-converting enzyme by target enzyme-activated inhibitors and N-acylhydrazones." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21362.pdf.

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31

Fienberg, Stephen. "Development of N-domain selective Angiotensin-I Converting Enzyme (ACE) inhibitors using Computer Aided Drug Discovery (CADD)." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25656.

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Angiotensin-I (Ang-I) converting enzyme (ACE) is a zinc metalloprotease that plays a vital role in the Renin Angiotensin Aldosterone System (RAAS) and is a key antihypertensive drug target. In addition to Ang-I, ACE cleaves many other physiological substrates, thus extending its function beyond the regulation of blood pressure. Somatic ACE (sACE) consists of two structurally homologous yet distinct catalytic sites termed the N- and C-domains. The two catalytic domains of ACE have distinct substrate affinities and play different regulatory roles. The antifibrotic tetrapeptide Ac-SDKP is hydroly

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32

Enous, Ridwaan. "Effect of angiotensin II, norepinephrine and the ace inhibitor, perindoprilat on the arrhythmogenic transient inward current of single isolated guinea pig and rabbit ventricular myocytes." Thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/25755.

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Seletswane, Dineo Precious. "Usage patterns and cost analysis of angiotensin-converting enzyme (ACE) inhibitors using a medical aid claims database / Dineo Precious Seletswane." Thesis, North-West University, 2004. http://hdl.handle.net/10394/357.

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ACE inhibitors have been widely used in the treatment of certain diseases of the cardiovascular system, the major use being hypertension, since all ACE inhibitors are prescribed for its treatment. ACE inhibitors is also used in the treatment of congestive heart failure. The angiotensin-converting enzyme (ACE) converts angiotensin 1 into angiotensin I1 and also stimulates the production of aldosterone (a hormone produced in the adrenal glands that influences salt and water retention by the kidneys, increasing blood volume and blood pressure). The cost benefit, cost-effectiveness and cost utilit

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34

Baker, Amanj. "Investigating the implementation and impact of 'Better Care Better Value' prescribing policy for Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for treating hypertension in the UK primary care setting." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/31153/.

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Background: In April 2009, the NHS Institute for Innovation and Improvement released four Better Care Better Value (BCBV) prescribing indicators. One indicator targeted renin–angiotensin–aldosterone system (RAAS) drugs, i.e., angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), to improve their prescribing efficiency. The indicator affects the proportion of items written for ACEIs as a percentage of the total number of prescriptions for RAAS drugs. A proportion of 80% ACEIs has been proposed and considered as an achievable target based on the small proport

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35

Chisi, John Eugenes. "The regulatory role of AcSDKP and angiotensin 1-converting enzyme (ACE) inhibitors on haematopoietic stem and progenitor cell proliferation." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14971.

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Negative regulatory factors inhibit the proliferation of haematopoietic stem cells thus protecting them from differentiation pressures. One of the negative regulators of stem cell proliferation is the tetrapeptide Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP). This peptide is endogenously produced in vivo and long term bone marrow cultures and is degraded by angiotensin 1-converting enzyme (ACE) both in vivo and in vitro. The aim of these investigations was to study the role of ACE on haematopoietic stem and progenitor cell proliferation. Since the N-domain ACE active has been implicated in AcS

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36

Garazdiuk, O. I., O. Yu Olinyk, I. V. Garazdiuk, and O. V. Kokoshchuk. "Monotherapy with angiotensin-converting enzyme inhibitors and combined antihypertensive therapy in patients with diabetic nephropathy and obesity: retrospective study." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17105.

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37

Amazonas, Roberto Bleuel. "Alterações renais precoces em um modelo experimental que combina hipertensão arterial genetica e diabetes mellitus : efeitos do tratamento anti-hipertensivo." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309966.

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Orientador: Jose Butori Lopes de Faria<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-07T11:40:18Z (GMT). No. of bitstreams: 1 Amazonas_RobertoBleuel_D.pdf: 3511441 bytes, checksum: b4fcb466c8675ae1dba5206babaf5e15 (MD5) Previous issue date: 2006<br>Resumo: No diabetes mellitus (DM), a hipertensão arterial (HA) é o principal fator associado ao desenvolvimento e progressão da nefi-opatia diabética (ND). Os mecanismos de interação entre HA e DM no agravamento da ND são pouco conhecidos. No presente trabalho investig

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38

Hechter, Sloane. "Factors that limit exercise performance and the use of angiotensin-converting enzyme inhibitors in adult survivors of the Mustard procedure." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58704.pdf.

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Mnguni, Ayanda Trevor. "The effects of angiotensin converting enzyme inhibitors (ACEI) on human N-acetylseryl-aspartyl-lysyl-proline (AcSDKP) levels : a systematic review." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/19896.

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Background: Tuberculous pericardial effusion is a pro-fibrotic condition that is complicated by constrictive pericarditis in 4-8% of cases. N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP) is a ubiquitous tetrapeptide with antifibrotic properties that is low in tuberculous pericardial effusion, thus providing a potential mechanism for the heightened fibrotic state. Angiotensin converting enzyme inhibitors (ACEI), which increase Ac-SDKP levels with antifibrotic effects in animal models, are candidate drugs for preventing constrictive pericarditis if they can be shown to have similar effects on Ac

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Duan, Qingling. "Pharmacogenomics and genetic risk factors of coronary artery disease." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115665.

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Coronary artery disease (CAD) is the most prevalent disorder and the leading cause of death worldwide. There are a number of CAD medications, which are effective and safe in most patients, but have been associated with adverse reactions such as angioedema induced by angiotensin I-converting enzyme inhibitors (AE-ACEi). In this study, we identified aminopeptidase P (APP) activity as an endophenotype for AE-ACEi, which is a heritable quantitative trait (heritability =0.336 +/- 0.251 SD) and is significantly reduced in a majority of our cases. Although initial mutation screening did not reveal an

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41

Khamanga, Sandile Maswazi Malungelo. "Formulation and evaluation of captopril loaded polymethacrylate and hydroxypropyl methycellulose microcapsules." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1013443.

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Angiotensin-converting enzyme (ACE) inhibitors are some of the most commonly prescribed medications for hypertension. They are cited in many papers as the treatment most often recommended by guidelines and favoured over other antihypertensive drugs as first-line agents especially when other high-risk conditions are present, such as diabetic nephropathy. The development of captopril (CPT) was amongst the earliest successes of the revolutionary concept of structure-based drug design. Due to its relatively poor pharmacokinetic profile or short half-life of about 1 hour, the formulation of sustain

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42

Kuntze, Luciana Bärg. "Efeito inibitório do captopril sobre a Metaloproteinase-2 da Matriz Extracelular (MMP-2) in vitro." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-27072016-160209/.

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A MMP-2 é uma protease que está envolvida em muitos eventos fisiológicos e patológicos e que compartilha similaridades estruturais com a enzima conversora de angiotensina (ECA), de modo que os inibidores da ECA passaram a ser estudados com relação ao efeito inibitório também sobre a MMP-2. No entanto, este potencial inibitório não foi ainda testado na MMP-2 altamente purificada. Este estudo teve como objetivo investigar o potencial inibitório do captopril sobre a atividade da MMP- 2. Primeiramente, supôs-se que a dissolução do captopril poderia induzir a mudanças no pH de soluções tampão. Em s

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43

Johnson, Andrew William. "Protection against Angiotensin II-induced endothelial dysfunction and hypertension via small molecule inhibitors of signal transducer and activator of transcription 3." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2903.

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Angiotensin II (Ang II) promotes vascular disease and hypertension in part by the formation of pro-inflammatory cytokines, oxidative stress and inflammation. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor known to play key roles in cytokine signaling and growth in immune cells. We tested the hypothesis that STAT3 plays an essential role in Ang II-induced vascular dysfunction and hypertension. Responses of carotid arteries from C57BL6 mice were examined in vitro after 22-hour incubation

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44

Vukadinovic, Davor [Verfasser]. "Evaluation of placebo-adjusted cough on angiotensin-converting-enzyme inhibitors and hyperkalemia on mineralocorticoid-receptor-antagonists in patients with cardiovascular disease / Davor Vukadinovic." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1223925250/34.

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Samnegård, Björn. "Renal effects of C-peptide in experimental type-1 diabetes mellitus /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-502-X/.

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Olivera, Carolina Maria Xaubet. "Estudo da utilização dos inibidores da enzima conversora da angiotensina, captopril e enalapril, dispensados pelas farmácias das unidades públicas de saúde do Distrito Oeste de Ribeirão Preto-SP." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-17072009-111259/.

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Os inibidores da enzima conversora da angiotensina são uma classe de medicamentos freqüentemente prescrita pelos médicos e importante para o tratamento da Hipertensão Arterial Sistêmica (HAS) e da Insuficiência Cardíaca Congestiva (ICC). Os dois primeiros protótipos desta classe, o captopril e o maleato de enalapril, constam na Relação Nacional de Medicamentos Essenciais (RENAME) devido à importância terapêutica, eficácia clínica e segurança comprovada, além de seu custo-efetividade. Para cumprir o objetivo de estudar a utilização desta classe terapêutica foi realizado um levantamento no banco

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Hollmann, Caryl. "A systematic review of outcomes associated with withholding or continuing angiotensinconverting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) prior to noncardiac surgery." Master's thesis, Faculty of Health Sciences, 2019. https://hdl.handle.net/11427/31682.

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Introduction The global rate of major noncardiac surgical procedures is increasing annually, and of those patients presenting for surgery increasing numbers are taking either an angiotensin-converting enzyme inhibitor (ACE-I) or an angiotensin receptor blocker(ARB). The current recommendations whether to continue or withhold ACE-I and ARB in the perioperative period are conflicting. Previous metaanalyses have linked preoperative ACE-I /ARB therapy to the increased incidence of post induction hypotension, however have failed to correlate this with adverse patient outcomes. The aim of this m

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Minuzzo, Luiz. "Relação entre inibição da enzima de conversão da angiotensina e elevação da Troponina I cardíaca em pacientes com síndrome coronária aguda sem supradesnivelamento do segmento ST." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-24062013-111012/.

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Introdução: O tratamento da Síndrome Coronária Aguda (SCA) sem supradesnivelamento do segmento ST (SSST) sofreu grandes avanços nos últimos 20 anos, com a introdução de novos medicamentos e intervenções invasivas, que reduziram significativamente os eventos clínicos graves como morte e re(infarto), em curto, médio e longo prazos, a despeito dessa entidade ainda representar uma alta taxa de mortalidade no mundo ocidental. Entre os medicamentos, os inibidores da enzima conversora da angiotensina (IECA) tiveram um papel fundamental, demonstrando redução desses eventos em pacientes com alto risco

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Fontaine, David. "Analyse pharmacologique comparative de l'action vasculaire du ramipril et d'inhibiteurs de l'HMG-COA réductase sur l'aorte isolée de rat: perspectives d'applications cliniques." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211194.

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La prévention des maladies cardiovasculaires constitue actuellement une approche capitale dans la diminution de la mortalité au sein de nos pays industrialisés. Tous les facteurs de risques étant associés à une dysfonction endothéliale, nous nous sommes intéressés à deux classes de médicaments dont l’action bénéfique se situe, du moins en partie, au niveau de l’endothélium vasculaire :les inhibiteurs de l’enzyme de conversion de l’angiotensine (IECA) et les inhibiteurs de l’hydroxy-3-méthyl-3-glutaryl-Coenzyme A (HMG-CoA) réductase (statines).<p> Le présent travail contribue à l’étude in vitro

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Villain, Cédric. "Evaluation de la protection cardiovasculaire et rénale chez les sujets âgés atteints de maladie rénale chronique." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLV060.

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La maladie rénale chronique (MRC) touche 11% des adultes mais 30% des plus de 70 ans. La cohorte CKD REIN a inclus 3033 sujets atteints de MRC stades 3-4 en France (âge moyen 67 ans, 65% d’hommes) et a permis d’évaluer l’impact de l’âge sur la prise en charge des maladies cardiovasculaires (MCV) associées à la MRC et la néphroprotection. La prévalence totale des MCV était de 48%, avec des prévalences similaires pour les MCV athéromateuse et non-athéromateuse dans chaque groupe d’âge, excepté chez les ≥85 ans chez qui la MCV non-athéromateuse prédominait. Chez les patients <65 ans, 29% avaie

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