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Rozprawy doktorskie na temat „Anti-arthritis”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Mohajane, Mamohale. "Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/6340.

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Includes abstract.<br>Includes bibliographical references.<br>The H⁺ and Cu²⁺ equilibria of four glycine peptides (glycyl-glycine, glycyl-L-leucine, glycyl-L-phenylalanine and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode potentiometry and isothermal titration calorimetry at 25 °C and an ionic strength 0.15 M (NaCl). The terminal amine of the sarcosine peptides is more basic than the glycine analogues. The methyl group on the terminal amine (for sarcosine peptides)

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Podgorski, M. R. "Clinical and pathological significance of anti-lipocortin autoantibodies in rheumatoid arthritis." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328478.

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Cleaver, Catherine Sarah. "The role of interleukin-4 and interleukin-13 in the prevention of cartilage breakdown." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327238.

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Mohamed, Ahmed A. "Redox studies on the anti-rheumatoid arthritis gold drugs : Auranofin and Solganol /." Fogler Library, University of Maine, 2000. http://www.library.umaine.edu/theses/pdf/MohamedAA2000.pdf.

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Dunagan, Fiona M. "Non-steroidal anti-inflammatory drugs : pharmacokinetics and clinical response in rheumatoid arthritis." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236497.

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Mercer, Louise. "Safety of long-term anti-TNF use, with respect to malignancy, in a national cohort of people with rheumatoid arthritis." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/safety-of-longterm-antitnf-use-with-respect-to-malignancy-in-a-national-cohort-of-people-with-rheumatoid-arthritis(be2ba2c3-a9a2-4a23-a3fb-c5688e990f93).html.

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AimThe broad aim of this thesis was to explore the risk of malignancy in people with rheumatoid arthritis (RA), treated with anti-tumour necrosis factor (TNF) drugs.MethodsThis thesis used data from patients with RA registered with the British Society of Rheumatology Biologics Register-RA. The risk of cancer in biologic-naive patients treated with traditional disease modifying drugs (nbDMARD) was compared to that in the general population by calculating standardised incidence ratios (SIR). The influence of anti-TNF on cancer risk was then explored by comparing the risk in the anti-TNF cohort t

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7

Mullazehi, Mohammed. "Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis." Doctoral thesis, Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100483.

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Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory features that primarily affects small peripheral joints. Type II collagen (CII), is the most abundant collagen type in joint cartilage. Antibodies against CII (anti-CII) are found in a subpopulation of RA patients. Anti-CII can form surface-bound immune complexes (IC) in inflamed joints, which might intensify joint inflammation and destruction. In this thesis I have studied the functional effects of surface-bound anti-CII–containing IC in vitro and correlated the results to clinical parameters. Anti-CII IC induced TN

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8

Phua, K. K. "The relationship between rheumatoid-factor and anti-strptococcal peptidoglycan antibody in rheumatoid arthritis." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370866.

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SILVA, JÚNIOR Auvani Antunes da. "Imunossensor baseado em grafeno-polissulfona para detecção da artrite reumatoide: antipeptídeo citrulinado." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17776.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-09-01T12:21:37Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) DISSETAÇAO_DEPOSITO.pdf: 1662534 bytes, checksum: 6bdb1ae293f1a65771c195438f64d3f0 (MD5)<br>Made available in DSpace on 2016-09-01T12:21:38Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) DISSETAÇAO_DEPOSITO.pdf: 1662534 bytes, checksum: 6bdb1ae293f1a65771c195438f64d3f0 (MD5) Previous issue date: 2016-03-09<br>CAPEs<br>A artrite reumatóide (AR) é uma do

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Hui, Kwun-ho. "The diagnostic and prognostic value of anti-CCP assay in the juvenile idiopathic arthritis (JIA)." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971817.

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Klingner, Maria Brigitte. "Untersuchung zur Vorhersagbarkeit des Therapieansprechens unter anti-TNF-Therapie bei Patienten mit Rheumatoider Arthritis." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-146837.

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Die Rheumatoide Arthritis (RA) ist eine der häufigsten Autoimmunerkrankungen des Menschen. Sie ist durch einen chronischen Verlauf mit Allgemeinsymptomen und erosiven Gelenkentzündungen gekennzeichnet. Die klinischen Beschwerden reichen von Morgensteifigkeit der Gelenke bis zu deren Funktionsverlust mit Deformationen. Extraartikuläre Manifestationen, vor allem das kardiovaskuläre System betreffend, erschweren den Krankheitsverlauf und verkürzen die Lebenserwartung. In der Pathogenese der RA steht die Synovitis, die Entzündung der Gelenkinnenhaut, im Mittelpunkt. Die Ansammlung von Lymphozyten

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12

Hatch, Lashley. "Statistical Information Included in Labeling for Disease-Modifying Anti-Rheumatic Drugs for Rheumatoid Arthritis." The University of Arizona, 2012. http://hdl.handle.net/10150/623641.

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Class of 2012<br>Specific Aims: To evaluate the presence of statistical information from clinical studies in official product labeling specific for disease-modifying anti-rheumatic drugs (DMARDs) used in the treatment of rheumatoid arthritis. Methods: Data were abstracted from official product labeling DMARDs with FDA approval for treatment of rheumatoid arthritis. Each document was examined for the presence of statement regarding a priori type 1 error rate, p-values, and measures of variance. Medications were classified as either biologic or non-biologic. Main Results: A total of 14 DMARDs,

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Hatch, Lashley, and Daniel C. Malone. "Statistical Information Included in Labeling for Disease-Modifying Anti-Rheumatic Drugs for Rheumatoid Arthritis." The University of Arizona, 2012. http://hdl.handle.net/10150/614497.

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Class of 2012 Abstract<br>Specific Aims: To evaluate the presence of statistical information from clinical studies in official product labeling specific for disease-modifying anti-rheumatic drugs (DMARDs) used in the treatment of rheumatoid arthritis. Methods: Data were abstracted from official product labeling DMARDs with FDA approval for treatment of rheumatoid arthritis. Each document was examined for the presence of statement regarding a priori type 1 error rate, p-values, and measures of variance. Medications were classified as either biologic or non-biologic. Main Results: A tot

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14

Chen, Qilei. "Discovery of COX-2 selective inhibitors from saussurea laniceps using an enzyme-anchored nanomagnetic ligand fishing platform." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/708.

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Serious cardiovascular side effects are reported from synthetic cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs, the most common medication for rheumatoid arthritis (RA) and osteoarthritis (OA). Natural products from herbal medicine are inspirational source of safe and effective remedy due to its distinguished chemical diversity. Nanomagnetic ligand fishing using enzyme-anchored-magnetic nanoparticles (MNPs) is an advanced selective bioseparation strategy based on macromolecular target-ligand binding, which can screen enzyme inhibitors from complex mixtures. "Snow lotus

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15

Hui, Kwun-ho, and 許冠浩. "The diagnostic and prognostic value of anti-CCP assay in the juvenile idiopathic arthritis (JIA)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971817.

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16

MARIANO, Maria Helena Q. Araújo. "Artrite reumatóide: avaliação de citocinas (IL-6e IL-10) da frequência da IgG do parvovírus B19 e desenvolvimento de um biossensor para antipeptídeo citrulinado cíclico (ACCP)." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/18298.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-02-13T14:07:28Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) tese completa corrigida_junho (2016).pdf: 2219391 bytes, checksum: 7ac2338dbd07d9a53a3344311f51b5ce (MD5)<br>Made available in DSpace on 2017-02-13T14:07:29Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) tese completa corrigida_junho (2016).pdf: 2219391 bytes, checksum: 7ac2338dbd07d9a53a3344311f51b5ce (MD5) Previous issue date: 2014-05-26<br>A artrite

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17

Skeoch, Sarah. "Investigation of atherosclerosis and the effects of anti-inflammatory therapy on plaque morphology in rheumatoid arthritis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-atherosclerosis-and-the-effects-of-anti-inflammatory-therapy-on-plaque-morphology-in-rheumatoid-arthritis(971c3727-54a8-49ff-aab7-8a6e0aa9d1ba).html.

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Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune condition, characterised by an inflammatory arthritis. It is associated with a 50% increased risk of cardiovascular (CV) mortality. Chronic inflammation is thought to lead to accelerated atherosclerosis in RA. There is some evidence to suggest that patients have a more inflammatory, unstable atherosclerotic plaque phenotype. The impact of advances in RA treatment, on cardiovascular co-morbidity remains unclear. The aims of the current study were to employ non-invasive imaging techniques to test the hypothesis that RA patients hav

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18

Shabani, Fariba. "Regulation of matrix metalloproteinases, their inhibitors and IL-8 in inflammatory rheumatic diseases : effects of cytokines and anti-rheumatic agents /." Title page and contents only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs524.pdf.

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Muhammad, Khalid. "Longterm impact of anti-CD20 mediated transient B cell depletion on memory B cells in patients with rheumatoid arthritis." Doctoral thesis, kostenfrei, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-36319.

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B-Lymphozyten leisten unterschiedliche Beiträge zur Pathophysiologie der Rheumatoiden Arthritis. Sie produzieren Autoantikörper, präsentieren Autoantigene und schütten verschiedene Zytokine, die am proinflammatorischen Prozess beteiligt sind, aus. Aufbauend auf diesen Ergebnissen wurden in den letzten Jahren Therapien entwickelt, die gezielt B-Lymphozyten ansteuern um direkt oder indirekt in den autoimmunen Krankheitsverlauf einzugreifen. Die zeitlich begrenzte B-Zell-Depletion mit Rituximab (anti CD20-Antikörper) hat dabei in den letzten Jahren einen hohen Stellenwert erlangt und wird im klin

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20

Leblanc, Daren James. "Thiol complexes of gold(I), structure and chemistry of the gold based anti-arthritis drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0018/NQ30153.pdf.

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LeBlanc, Daren James. "Thiol complexes of gold(I) : structure and chemistry of the gold based anti-arthritis drugs /." *McMaster only, 1996.

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Coulthard, Lydia Ruth. "Cellular and molecular mechanisms of non-response to anti-TNF therapy in rheumatoid arthritis patients." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521447.

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Rossato, Elisabetta. "Anti-inflammatory role of monomeric IgA through the inhibitory FcαRI-ITAMi signaling in rheumatoid arthritis". Paris 7, 2014. http://www.theses.fr/2014PA077056.

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De par leur hétérogénéité, les IgA possèdent des propriétés pro- ou anti-inflammatoires et contribuent à l'homéostasie immunitaire. Ces activités dépendent de l'interaction des IgA avec le récepteur RFcal contenant le motif ITAM (immunoreceptor tyrosine-based motif). Les IgA sous forme de complexes entraînent une activation pro-inflammatoire, tandis qu'en l'absence d'antigène, celles-ci (ou le fragment Fab d'un anticorps anti-RFcat) engendrent un signal anti-inflammatoire (nommé ITAMi ou ITAM inhibiteur) capable d'inhiber l'activation des récepteurs hétérologues. L'ITAMi nécessite, au niveau d

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24

Brink, Mikael. "Presence of immunological markers preceding the onset of rheumatoid arthritis." Doctoral thesis, Umeå universitet, Reumatologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102589.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease with an unknown aetiology characterized by joint destruction. Both genetic and environmental factors contribute to the disease development with HLA-DRB1* alleles and smoking identified as most important. The disease is characterized by the presence of autoantibodies, originally by rheumatoid factor (RF) and more recently by anti citrullinated protein/peptide antibodies (ACPA) and antibodies against carbamylated peptides (CarP). These autoantibodies are present, not only after the onset of disease, but also prior to the onset of sympto

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Koenen, Mascha [Verfasser]. "GR actions in stromal cells suppress inflammatory arthritis by induction of anti-inflammatory macrophages / Mascha Koenen." Ulm : Universität Ulm, 2019. http://d-nb.info/1178527956/34.

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Carty, Sara Madelaine. "IL-6 SIL-6r in rheumatoid arthritis : interplay with TNFa and implications in anti-TNFa therapy." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55795/.

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Recent advances in the therapeutic management of rheumatoid arthritis have identified that selective targeting of inflammatory cytokines represents a valid approach to the treatment of rheumatoid arthritis (RA). Although blockade of the inflammatory response at its inception by anti-TNFalpha agents has shown considerable clinical promise, this approach is not without its drawbacks. Consequently, identification of novel therapeutic strategies is essential. In recent clinical trials, favourable results were found with modalities that block interleukin-6 signalling. However, it is unclear whether

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Manivel, Vivek Anand. "The role of anti-collagen type II antibodies in the pathogenesis and prognosis of rheumatoid arthritis." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311959.

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Rheumatoid arthritis (RA) which affects 0.5-1% of the world population and is characterised by joint erosions and presence of the autoantibodies anti-citrullinated protein antibodies (ACPA) and rheumatoid factor. Collagen II (CII) is a joint-specific antigen and we have shown that antibodies against CII (anti-CII) are present in around 8% of RA patients. RA patients with anti-CII are characterized by acute RA onset with elevated CRP and early joint erosions at the time of RA onset. Polymorphonuclear granulocytes (PMN) and peripheral blood mononuclear cells (PBMC) are abundant in RA synovial fl

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Gondim, Delane Viana. "Antinociceptive and ANTI-INFLAMMATORY ARTHRITIS IN electroacupuncture INDUCED zymosan TMJ OF RATS: INVOLVEMENT OF endocannabinoid system." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10493.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Electroacupuncture (EA) and cannabinoids have been reported to have anti-inflammatory and antinociceptive effects in experimental models of inflammatory pain. The present study investigated these effects on zymosan-induced acute arthritis of the rat temporomandibular joint (TMJ). Male Wistar rats were injected with saline or zymosan (control group; 2 mg) into the TMJ. Low frequency EACP (10 Hz, 30 min) was performed at acupoints (LI4, LI11, ST36, ST44) or sham points 2 h after or 1 h before zymosan administration. CB1 and CB2 canna

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Semerano, Luca. "Active anti-TNF alpha immunization in a murine model of rheumatoid arthritis : Relevance to human disease." Paris 13, 2013. http://www.theses.fr/2013PA132018.

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Current anti-TNFα treatments (monoclonal antibodies or soluble receptors) radically changed the treatment of rheumatoid arthritis (RA) and other TNFα-related diseases, but even show several drawbacks as far as safety, efficacy and costs are concerned. Active immunization with human TNFα kinoid (TNF-K) is an alternative anti-TNFα strategy that exploits vaccination principle in order to induce the production of polyclonal anti-TNFα Abs by recipients. We show the feasibility of this approach in a disease model that mimics the main features of human RA and that depends on deregulated TNFα producti

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Mhlambiso, Zizile. "Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/9280.

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Includes bibliographical references.<br>It has been shown that copper complexes are able to alleviate inflammation associated with Rheumatoid Arthritis (RA). Serum copper levels are elevated in RA and it has been postulated that endogenous copper might have a protective function in chronic inflammatory conditions. In designing Cu(I1) anti-inflammatory drugs, one needs to know the stability constants of the ligand together with Cu(I1) and the competitive metal ions, Zn(I1) and Ca(I1) in blood plasma. For this purpose glass electrode potentiometry, infrared (lR) spectroscopy, nuclear magnetic re

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Robey, Ian Forrest. "Binding and functional properties of natural anti-T cell receptor antibodies in patients with rheumatoid arthritis." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/289736.

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Natural autoantibodies specific for the T cell receptor (TCR) are present in all human sera. Differences in titer, epitope specificity, and isotype depend on physiological condition, viral infections, or the presence of autoimmune diseases. Individuals with rheumatoid arthritis (RA) make significantly higher titers of IgM isotype autoantibodies demonstrating major reactivity for the CDR1 region of the Vβ TCR. To establish a more intimate understanding of the role of these antibodies in the immune system we generated B cell hetero-hybridomas secreting monoclonal IgM autoantibodies from the syno

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Ishigooka, Nozomi. "Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245829.

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京都大学<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第22144号<br>医博第4535号<br>新制||医||1039(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授松田秀一, 教授生田宏一, 教授杉田昌彦<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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Ellis, S. D. P. "The induction and characterisation of CD8+FOXP3+ regulatory T cells by anti-CD3 mAb in inflammatory arthritis." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1432347/.

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Limiting the severity of inflammation and promoting its eventual resolution are vital for protecting host tissues both in autoimmunity and inflammation. In this thesis, I describe a potent CD8+FOXP3+ regulatory T cell (Treg) population in patients with rheumatoid and psoriatic arthritis, which can be induced from peripheral blood mononuclear cells after stimulation with different clones of anti-CD3 mAb, including OKT3 and the non Fc-receptor binding antibody otelixizumab. CD8+FOXP3+ Treg inhibited Th17 responses, thereby functioning to limit a wider range of inflammatory pathways compared to C

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Zvimba, John Ngoni. "Copper chelating anti-inflammatory agents of pseudo-mimics of Human Serum Albumin (HSA): copper and rheumatoid arthritis." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/6278.

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Vugler, Alexander David. "Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494617.

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Novel anti-arthritic drugs are often assessed in murine collagen-induced arthritis (CIA), which is a widely used pre-clinical model of rheumatoid arthritis. However, CIA studies are lengthy, development of arthritis is not synchronised and not all animals develop disease. Work conducted in this thesis addressed some of these issues by developing short-term mechanistic models of collagen II (CII) immunity. Drug effects on Cll-induced hypersensitivity, anti-CII antibodies and ex vivo CII stimulated CD4⁺ T cell proliferation in mice 14 days post-CII sensitisation were assessed and compared to the

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Nama, Nelisa Petronella Vuyo. "Potentiometric and spectrophotometric investigation of copper diclofenac as an anti inflammatory drug for the treatment of Rheumatoid Arthritis." Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/6349.

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Includes bibliographical references.<br>Copper and Diclofenac (DCL) separately, are used to alleviate inflammation associated with RA. It has been postulated that their combination would have a synergistic effect i.e., their combination would be more effective than when administered independently. Cu(II)-DCL system is studied potentiometrically in order to evaluate this hypothesis.

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Galarraga, Bernat. "Effect of anti-rheumatic therapy, folic acid supplementation and allopurinol on surrogate markers of cardiovascular disease in Rheumatoid arthritis." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505630.

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Zielke, Robert [Verfasser]. "Strukturelle und morphologische Veränderungen am Auge bei Patienten mit anti-CCP-positiver Rheumatoider Arthritis und arterieller Hypertonie / Robert Zielke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1056907819/34.

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Nakabo, Shuichiro. "Carbamylated albumin is one of the target antigens of anti-carbamylated protein antibodies." Kyoto University, 2017. http://hdl.handle.net/2433/226765.

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Barrios-Rodiles, Miriam. "Regulation of cyclooxygenase-2 expression in human macrophages." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0033/NQ64507.pdf.

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Hayball, Peter John. "Chirality in clinical pharmacology : studies with ketoprofen /." Title page, contents and abstract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh413.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1993?<br>Copies of author's previously published articles in back-cover pocket. Includes bibliographical references (leaves 180-205).

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Krasnitski, Raisa [Verfasser]. "Calprotectin bei DMARD (Disease Modifying Anti-Rheumatic Drug)-naiver früher rheumatoider Arthritis als Aktivitäts- und Verlaufsmarker unter Therapie / Raisa Krasnitski." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1228861064/34.

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Glötzner, Marietta [Verfasser], and Dirk [Akademischer Betreuer] Reinhold. "Biomarker basierte Vorhersage eines Therapieerfolges einer anti-TNF-alpha-Therapie bei Patienten mit rheumatoider Arthritis / Marietta Glötzner. Betreuer: Dirk Reinhold." Magdeburg : Universitätsbibliothek, 2013. http://d-nb.info/1054135967/34.

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Bendlin, Barbara Brigitta. "The Role of Anti-inflammatory Agents in White Matter and Gray Matter Integrity in Older Age with Special Consideration of the Arthritis Patient." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194320.

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A number of studies have indicated that individuals with arthritis have a decreased risk for Alzheimer's disease (AD). Inflammatory processes are implicated in the neurodegeneration associated with AD and the reduced risk associated with arthritis may be due to the anti-inflammatory (AI) drugs used by these individuals. The present project used magnetic resonance imaging (MRI) to assess the integrity of gray and white brain matter in AI users compared to controls not taking AIs. Thirty six female AI users were compared to thirty three controls. All participants underwent extensive neuropsy

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Sampey, Annaleise 1972. "Effect of two glucocorticoid-inducible proteins on human fibroblast-like synoviocytes." Monash University, Dept. of Medicine, 2001. http://arrow.monash.edu.au/hdl/1959.1/8948.

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Heilborn, Umut. "Behavioural and neurochemical effects of long-lasting inflammatory pain /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-175-3/.

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Komolafe, Ayoola Oluwakayode. "An open-label, randomized, crossover study to assess anti-inflammatory effect of Simvastatin in Rheumatoid Arthritis statin-naïve patients with associated risk factors for cardiovascular disease." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40713.

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Rheumatoid arthritis (RA) is a chronic inflammatory condition of unknown etiology for which there is no cure. It is one of the most disabling diseases and affects about 1% of the world‟s population. Recent developments in the field of molecular biology have resulted in the production of new drugs used in the treatment RA. Despite these advancements, achieving optimal disease control and prevention of disease progression is still difficult in many patients, leading to a continued search for treatment methods that will improve patient outcomes. Non-biologic forms of treatment that are still

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Hamann, Philip. "An investigation into the predictors and frequency of sustained remission in patients with rheumatoid arthritis undergoing treatment with anti-tumour necrosis factor therapy using the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760961.

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Background. Response to anti-tumour necrosis factor (anti-TNF) therapy in patients with rheumatoid arthritis (RA) varies between patients. Incidence of sustained remission in the UK is not known, and factors contributing to its achievement are poorly understood. Prior knowledge of response would enable better targeting of anti-TNF therapy, leading to better outcomes and reduced morbidity. Aims. This thesis aims to identify incidence of sustained remission and low disease activity (LDA) in patients with rheumatoid arthritis (RA) taking anti-TNF therapy. Clinical and demographic factors associat

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Hull, Dobrina Nikolaeva. "The dynamics of Th17 and Th1 cells during anti-TNF therapy in patients with inflammatory arthritis and relationship with treatment response." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29116.

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Anti-TNF agents have revolutionised the treatment of rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), however a significant proportion of patients respond inadequately. Studies in murine and human arthritis have paradoxically shown that anti-TNF treatment can increase circulating Th17 and Th1 cells but the relationship of these changes to treatment response remains unclear. The aim of the work in this thesis was to conduct a prospective, longitudinal investigation of patients with inflammatory arthritis during anti-TNF treatment and using clinical, ultrasou

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Sá, Mariana Castilho Mamede Xavier de. "Novos sistemas terapêuticos de administração transcutânea." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4639.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A pele tem sido cada vez mais, uma alternativa para administração de fármacos. A administração transcutânea é uma das vias de administração cutânea, que visa a cedência de fármacos para a epiderme ou derme, onde vão exercer o seu efeito a nível local ou sistémico. Para que os fármacos exerçam o seu efeito, nos locais alvo, têm que atravessar o estrato córneo e como tal, têm que ser vectorizados recorrendo-se assim, à nanomed

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