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Rozprawy doktorskie na temat „Anti-atherosclerosis”

Autor: Grafiati
Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Layne, Kerry Anne. "Anti-inflammatory effects of anti-platelet drugs : implications for atherosclerosis." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/antiinflammatory-effects-of-antiplatelet-drugs(1da58105-e415-4241-a696-effb35badd21).html.

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Cardiovascular disease secondary to atherosclerosis is the leading cause of death worldwide. The pathophysiology of atherosclerosis is multifactorial and complex. This thesis offers insight into the regulation of several potential biomarkers of cardiovascular disease and explores the effects of anti-platelet therapy in modulating these pathways. CD14highCD16+ monocytes are elevated in patients with atherosclerosis and may be predictive of future cardiovascular events. The initial study in this PhD project assessed the effects of anti-platelet drugs on the phenotype of circulating monocytes in
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Nation, Daniel Addison. "The Oxytocinergic Anti-Inflammatory Pathway in Atherosclerosis." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/268.

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Background. Social deprivation or isolation accelerates the progression of atherosclerosis in several animal models of the disease. Conversely, stable social environment has been associated with reduction in the extent and severity of atherosclerosis. While positive social interactions are thought to be related to this protective effect, little is known about the physiological mechanisms responsible. Recently, the neurohypophyseal peptide, oxytocin (OT), has been found to play a role in both positive social interactions and cardiovascular homeostasis, suggesting that this neuropeptide ma
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Moss, Joe. "Anti-inflammatory actions of nutraceuticals : novel emerging therapies for atherosclerosis?" Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/111849/.

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Background Cardiovascular disease (CVD)-related events such as myocardial infarction and stroke remain the world’s leading cause of death. The incidence of CVD-related events is expected to rise in the future due to the increase in the global prevalence of obesity and diabetes, in addition to less economically developed countries adopting a western style diet. Atherosclerosis is a chronic inflammatory disease which is the underlying cause of CVD and characterised by the build-up of fatty deposits within the walls of medium and large arteries. Macrophages play critical roles during the pathogen
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Khamis, Ramzi Yousef Jabra. "Anti-oxidised low density lipoprotein antibodies for the serology and imaging of atherosclerosis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/45407.

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Atherosclerosis and its related major adverse cardiovascular events represent a major worldwide morbidity and mortality burden. The paradigm of identifying ‘vulnerable plaques’ leading to ‘vulnerable patients’ remains challenging despite recent advances in cardiovascular medicine. The project aimed to develop an antibody-based strategy for the translational development of imaging oxidised low density lipoprotein (LDL), a major constituent of vulnerable atherosclerotic plaque. It also aimed to simultaneously develop anti-oxidised LDL antibody-based serological assays for the stratification of i
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Clarke, S. C. "The effect of oestrogens and anti-oestrogens on plasma risk factors for coronary atherosclerosis and arterial flow-mediated vasodilation in patients with coronary atherosclerosis." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597727.

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Skeoch, Sarah. "Investigation of atherosclerosis and the effects of anti-inflammatory therapy on plaque morphology in rheumatoid arthritis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-atherosclerosis-and-the-effects-of-anti-inflammatory-therapy-on-plaque-morphology-in-rheumatoid-arthritis(971c3727-54a8-49ff-aab7-8a6e0aa9d1ba).html.

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Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune condition, characterised by an inflammatory arthritis. It is associated with a 50% increased risk of cardiovascular (CV) mortality. Chronic inflammation is thought to lead to accelerated atherosclerosis in RA. There is some evidence to suggest that patients have a more inflammatory, unstable atherosclerotic plaque phenotype. The impact of advances in RA treatment, on cardiovascular co-morbidity remains unclear. The aims of the current study were to employ non-invasive imaging techniques to test the hypothesis that RA patients hav
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7

Maurent, Kelly. "Synthèse de composés phénoliques de type diarylheptanoïde : évaluation de leurs propriétés antioxydantes et anti-inflammatoires." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30255/document.

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L'athérosclérose est une des premières causes de mortalité dans les pays industrialisés. Elle est à l'origine de diverses pathologies telles que les infarctus du myocarde, les accidents vasculaires cérébraux et les maladies des artères coronaires. Deux facteurs clés sont à l'origine de l'athérosclérose : 1) un stress oxydant qui conduit à l'oxydation des lipoprotéines de basse densité dans la paroi artérielle et qui constitue la première étape du processus athérosclérotique ; 2) un processus inflammatoire auto-entretenu qui permet le développement des dernières étapes de l'athérogénèse conduis
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8

Chaston, Reve W. "SERUM ANTI-PHOSPHORYLCHOLINE AND ANTI-CARDIOLIPIN CONCENTRATIONS FOLLOWING PERIODONTAL SCALING AND ROOT PLANING." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/834.

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Atherosclerosis is an insidious disease with serious morbidity and mortality including ischemic heart disease, stroke, and myocardial infarction. This condition is progressive and can start early in life eventually leading to large plaques and arterial occlusion. Two key components of this process are the immune system and lipids; in particular, LDL which accumulates within the arterial walls and macrophages which recognize and engulf oxidized-LDL (oxLDL) to form foam cells. Knowing that certain antibodies directed against bacterial antigens such as phosphorylcholine (PC) and cardiolipin (CL)
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9

Ganzetti, G. S. "USE OF GENETICALLY MODIFIED MICE TO STUDY THE ANTI-INFLAMMATORY AND IMMUNOMODULATORY ROLE OF HIGH-DENSITY LIPOPROTEINS DURING ATHEROSCLEROSIS DEVELOPMENT." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/482886.

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Introduction: High-density lipoproteins (HDLs) have several anti-atherosclerotic/anti-inflammatory properties and the apolipoprotein A-I (apoA-I), the main protein component of HDL, plays a major role. The aim of the present project was to investigate the impact of apoA-I on atherosclerosis development, phenotype and inflammation, through the use of genetically modified mice. Methods: This study was performed in C57Bl/6 wild-type mice, resistant to atherosclerosis development, and in three athero-prone mouse lines: apoEKO, apoEKO with the additional deletion of murine apoA-I (dKO) and dKO ove
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10

Youssouf, Latufa. "Fonctionnalisation de biopolymères extraits de macroalgues pour encapsuler des principes actifs hydrophobes." Thesis, La Réunion, 2016. http://www.theses.fr/2016LARE0030/document.

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Le diabète est caractérisé par une hyperglycémie chronique mais également par un stress oxydant et une inflammation chronique conduisant à des complications cardiovasculaires telles que l'athérosclérose. La curcumine est un polyphénol connu pour ses propriétés antioxydantes et antiinflammatoires. Elle est capable de neutraliser les radicaux libres et les médiateurs inflammatoires impliqués dans le développement des maladies métaboliques. De ce fait, la curcumine peut avoir une action préventive contre le diabète de type 2 et ses complications cardiovasculaires. Cependant la curcumine, comme de
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11

Chan, Madelynn Tsu-Li. "Serological biomarkers in systemic lupus erythematosus." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607470.

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Background: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease characterised by autoantibody production and variable clinical features, ranging from mild to severe disease. Patients with SLE are at increased risk of developing accelerated atherosclerosis. Biomarkers have potential utility in SLE as markers of disease or predictors of future clinical events and mortality. Objective The aim of this thesis was to identify serological biomarkers predictive for erosive arthritis (EA), cardiovascular events (CVEs), mortality and subclinical atherosclerosis in SLE. Methods: In ch
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12

Guilherme, Daniel Ferreira. "Obtenção de GFP5-scFv recombinante reativo à LDL(-): possíveis aplicações na investigação da aterosclerose." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-16102012-144328/.

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A aterosclerose é a doença de base das principais complicações cardiovasculares. Os produtos de modificação das lipoproteínas de baixa densidade, como a subfração eletronegativa LDL (-), exercem um importante papel na progressão da aterosclerose. O objetivo do presente trabalho foi expressar a proteína de fusão, GFP5-scFv anti-LDL (-), desenvolver um método para detecção de LDL (-), assim como avaliar a possível utilização desta proteína como uma ferramenta para monitorar os ensaios de formação de células espumosas. A proteína GFP5-scFv anti-LDL (-) foi expressa em E. coli BL21DE3. Esta proteí
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13

Soubhye, Jalal. "Design, synthesis and study of myeloperoxidase inhibitors in the series of 3-alkylindole." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209402.

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The deleterious effects of MPO make it a new target for medicinal research. The aim of our study is to find promising inhibitors of MPO for using them as starting point of new anti-inflammatory drugs. Depending on previous researches on MPO inhibitors, we selected 5-fluorotryptamine as starting compounds. Using docking experiments, we designed a series of compounds derived from 5-fluorotryptamine. Two modifications were proposed: <p>&<br>Doctorat en Sciences biomédicales et pharmaceutiques<br>info:eu-repo/semantics/nonPublished
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14

Thomas, Anita C. "Targeted delivery of anti-restenotic agents /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17067.pdf.

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Martinic, Goran (Gary), of Western Sydney Hawkesbury University, of Science Technology and Environment College, and School of Environment and Agriculture. "Cyclodextrins as potential human anti-atherosclerotic agents." THESIS_CSTE_EAG_Martinic_G.xml, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for
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Dummler, Sara Katharina [Verfasser], Johann Josef [Akademischer Betreuer] Hauner, and Harald [Akademischer Betreuer] Lahm. "Genome-wide expression analysis of human bypass grafts with different degrees of atherosclerosis: Identification of an anti-apoptotic network and validation of the candidate genes in in vitro and ex vivo systems / Sara Katharina Dummler. Gutachter: Harald Lahm ; Johann Josef Hauner. Betreuer: Johann Josef Hauner." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1032693266/34.

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Zhang, Xiaohua. "Investigations of effects of garlic materials upon risk factors of atherosclerosis." Thesis, University of Wolverhampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323146.

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A brief review was provided of lipid metabolism, mechanisms of lipid lowering and coronary heart disease risk factors (including the role of antioxidants). In addition, studies of lipid-lowering and other anti-atherosclerotic effects of garlic materials were also reviewed. Evaluation and development of techniques required to perform studies of the anti-atherosclerotic effects of garlic were implemented, including evaluation of methods for measuring total antioxidant capacity and the development of methods for the rapid isolation of low density lipoprotein (LDL). The main objective of this proj
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Pereira, Ivânio Alves. "Aterosclerose na artrite reumatóide e sua associação com auto-imunidade humoral." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5145/tde-03052007-101757/.

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Objetivos: Muitas questões permanecem sobre as causas da aterosclerose acelerada nos pacientes com doenças inflamatórias sistêmicas como a artrite reumatóide (AR). Estudos na população geral sugeriram que além da inflamação existe uma participação patogênica da auto-imunidade na aterosclerose e discutem a possível associação dos anticorpos contra fosfolípides e proteínas de choque térmico (Hsp). O objetivo deste estudo foi investigar a presença de anticorpos contra fosfolípides, beta2-glicoproteína 1 (beta2-gp1), lipoproteína lipase (LPL) e Hsp em pacientes com AR e avaliar a associação entre
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Özgül, Mustafa Altınbaş Ahmet. "Deneysel ateroskleroz modelinde homosistein düşürücü ve antioksidan tedavinin anti-aterosklerotik etkinliği /." Isparta: SDÜ Tıp Fakültesi, 2006. http://tez.sdu.edu.tr/Tezler/TT00260.pdf.

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England, Ross N. "Cellular Mechanisms of the Anti-Inflammatory Effects of Interleukin-19." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216875.

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Physiology<br>Ph.D.<br>BACKGROUND: Atherosclerotic vascular disease is a significant medical and socioeconomic problem and contributes to mortality in multiple diseases including myocardial infarction (MI), stroke, renal failure, and peripheral vascular disease. Atherosclerosis, as well as other vascular diseases including post-intervention restenosis and allograft vasculopathy, is known to be driven by chronic inflammation and, consequently, pro- and anti-inflammatory cell signaling molecules have been an important target of cardiovascular research. Interleukin (IL)-19 is a recently discovere
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21

Richards, Jamie Madison. "The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/345114.

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Physiology<br>Ph.D.<br>Our lab has recently shown that IL-19 is expressed in angiogenic ECs, opening the possibility for its use as a medicine to increase perfusion in patients with PAD. The first aim of the current study is to show IL-19’s ability to increase perfusion in vivo using C57BL/6 wild type and IL-19 KO mice in the hindlimb ischemia (HLI) model. Wild-type mice injected with 10ng/g/day of rmIL-19 after being subject to hindlimb ischemia showed significantly greater levels of perfusion than PBS injected littermates. Immunohistochemistry of harvested gastrocnemius muscle showed a great
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Martinic, Gary. "Cyclodextrins as potential human anti-atherosclerotic agents." Thesis, View thesis View thesis, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for
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Cavalcante, Marcela Frota. "Efeito da imunização passiva com fragmentos variáveis de cadeia única anti-LDL eletronegativa na aterosclerose experimental." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-07032013-162526/.

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A aterosclerose é uma doença crônico-inflamatória multifatorial com o envolvimento do sistema imunológico, sendo o resultado da interação de diferentes elementos celulares. A lipoproteína de baixa densidade eletronegativa [LDL(-)], capaz de induzir o acúmulo de ésteres de colesterol em macrófagos e a subsequente formação de células espumosas, desempenha um papel-chave na doença. Anticorpos recombinantes têm sido gerados nas últimas décadas, como o scFv (single chain fragment variable), com o intuito de serem utilizados como uma novas alternativas de prevenção para o surgimento da lesão. Diante
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Herman, Allison. "RNA-binding proteins mediate anti-inflammatory regulation of vascular disease." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/554883.

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Biomedical Sciences<br>Ph.D.<br>This work identifies the Fragile X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMC). FXR1 was identified as an HuR interacting protein by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The-HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 expression is induced in diseased, but not normal arteries. SiRNA knock down of FXR1 increases abundance and stability of inflammatory mRNAs, while overexpression of FXR1 reduces t
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Andrade, Camila Marques de. "Avaliação do efeito anti-aterogênico dos fitoestrógenos na expressão de moléculas de adesão em células andoteliais Humanas." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-01122009-160045/.

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Os riscos provocados pela Terapia de Reposição Hormonal, levaram à busca de novas terapias, como os fitoestrógenos. São substâncias com ação estrogênica e propriedades que podem retardar a formação de placas ateroscleróticas. Isoflavonas são os fitoestrógenos mais estudados e são encontradas na soja, no red clover e em outras plantas. Avaliamos os efeitos dos fitoestrógenos extraídos da soja Glycine max: genisteína, formononetina, biocanina A e daidzeína; a mistura entre eles (Mix1); o extrato padronizado de red clover (Menoflavon 40mg) e uma segunda mistura com os fitoestrógenos extraídos da
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Rosini, Giulia. "New insights and tools to study innovative delivery strategies of therapeutic peptides: Apolipoprotein A-I Milano, administered orally via genetically modified rice plants, exerts anti-inflammatory effects in vivo." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1210413.

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In the proof-of-concept study published by Romano and others in Int.Cardiology 2018, was shown a new approach for treatment of cardiovascular disease (CVDs) because, despite the high therapeutic potential of Apolipoprotein A-I protein, the practical application is hampered by the low efficiency of purification and delivery. A genetically modified rice plants expressing Apolipoprotein A-I variant Milano (AIM) were created. The product was tested in vitro, and in vivo mouse atherosclerotic model treated with genetically modified rice-milk (in the form of protein extract of rice seed proteins) or
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QuinderÃ, Ana Luiza Gomes. "Structural characterization and anti-inflammatory activity in asterosclerose model in mice of a sulfada galactan red algae Acanthophora muscoide." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13995.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Sulfated galactans from red marine algae are polysaccharides with heterogeneous structures that have presented a variety of potentially therapeutic biological effects including anticoagulant, anti-thrombotic and anti-inflammatory, however, their potential activity as anti-inflammatory agent in the treatment of atherosclerosis, a chronic inflammatory disease that culminates with thromboembolic disorders, has not been previously studied. Furthermore, experimental data f
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Quinderé, Ana Luiza Gomes. "Caracterização estrutural e atividade anti-inflamatória em modelo de aterosclerose em camundongos de uma galactana sulfatada da alga vermelha Acanthophora muscoides." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/19404.

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QUINDERE, Ana Luiza Gomes. Caracterização estrutural e atividade anti-inflamatória em modelo de aterosclerose em camundongos de uma galactana sulfatada da alga vermelha Acanthophora muscoides. 2015. 152 f. Tese (Doutorado em Bioquímica)-Universidade Federal do Ceará, Fortaleza, 2015.<br>Submitted by Vitor Campos (vitband@gmail.com) on 2016-09-01T22:42:17Z No. of bitstreams: 1 2015_tese_algquindere.pdf: 1798137 bytes, checksum: c21776a201b808de159ff9bc73b36644 (MD5)<br>Approved for entry into archive by Jairo Viana (jairo@ufc.br) on 2016-09-02T21:05:07Z (GMT) No. of bitstreams: 1 2015_tese_a
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Nascimento, Caroline Michelis. "Correlações entre Doença Periodontal e Aterosclerótica Coronariana:presença de anticorpos Anti-Toxoplasma gondii em amostras de sangue, catéter e saliva humana." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2012. http://tede2.uepg.br/jspui/handle/prefix/1809.

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Made available in DSpace on 2017-07-24T19:22:25Z (GMT). No. of bitstreams: 1 Caroline Michelis Nascimento.pdf: 1850538 bytes, checksum: ef9b5b6eb0f2144523223dd6c55ee614 (MD5) Previous issue date: 2012-08-31<br>The occurrence of oral diseases is related to habits, stress levels, diet and emotional factors. The oral cavity is the site of entry for many microorganisms and are manifested niche where the first symptoms of a number of diseases of systemic character. Periodontal disease (PD) is a chronic infectiousinflammatory that affects the supporting tissues of the teeth and support, and toxopl
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Daleprane, Julio Beltrame. "Atividade anti-angiogênica e modulação das proteínas envolvidas na neoformação vascular por compostos bioativos da própolis." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9132/tde-01082011-161009/.

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Rica em compostos bioativos, a própolis é amplamente utilizada na medicina alternativa como agente preventivo e/ou terapêutico. Neste trabalho, avaliamos o impacto de frações ricas em polifenóis de diferentes própolis no processo de angiogênese na aterosclerose. Foram utilizadas as seguintes amostras de própolis: Red (vermelho, Alagoas-Brasil), Green (verde, Minas Gerais-Brasil) e Brown (marrom, Temuco-Chile), com concentrações semelhantes de polifenóis totais (~32%), porém com diferentes perfis de compostos fenólicos. A suplementação (250 mg/Kg/dia) de camundongos knockout para o receptor de
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Melo, Anderson Adriano Martins. "Estresse oxidativo em banana "Prata"; minimamente processada tratada com anti-oxidantes e avaliado em camundongo Apo-E-/-." Universidade Federal de Viçosa, 2010. http://locus.ufv.br/handle/123456789/981.

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Made available in DSpace on 2015-03-26T12:40:40Z (GMT). No. of bitstreams: 1 texto completo.pdf: 1482814 bytes, checksum: 870fe4fd9eb1be24c85fb657ac09e8cd (MD5) Previous issue date: 2010-10-29<br>Fundação de Amparo a Pesquisa do Estado de Minas Gerais<br>Fresh-cut banana is highly perishable, due to enzymatic browning and oxidative stress, which can cause degradation of membranes of plant tissue. Immersion of banana slices in chemical treatments can increase its shelf-life, and turning it a healthier product with a higher antioxidant capacity, as well as preventing the development of degen
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Conway, Daniel Elridge. "CYP1A1 and CYP1B1 expression and free zinc levels in endothelial cells are differentially regulated by pro-atherogenic versus anti-atherogenic shear stress." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33832.

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It is hypothesized that exposing endothelial cells to steady or non-reversing pulsatile shear stress produces a healthy, anti-atherogenic endothelium, whereas a reversing pulsatile shear stress promotes an unhealthy, pro-atherogenic endothelium. To further investigate this hypothesis, a novel parallel plate flow chamber system was used to expose human endothelial cells to a pro-atherogenic reversing shear stress waveform designed to simulate the wall shear stress at the carotid sinus, a region prone to atherosclerosis. Cells exposed to this reversing shear stress were compared to cells expos
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Raizman, Joshua E. "The Role of Scavenger Receptor-A in Heat Shock Protein 27-mediated Atheroprotection: Mechanistic Insights into a Novel Anti-atherogenic Therapy." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22836.

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Heat shock protein (HSP)27 is traditionally described as an intracellular chaperone and signaling molecule, but growing evidence suggests it is released from immune cells where it plays an anti-inflammatory role during atherogenesis. Previously, the O’Brien lab found that overexpression of HSP27 led to augmented HSP27 serum levels in female apolipoprotein E knockout (ApoE-/-) mice, attenuated atherogenesis, and inhibited macrophage foam cell formation via physical binding with scavenger receptor (SR)-A. However, the precise mechanism of atheroprotection remained elusive. This thesis sought to
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Joumard-Cubizolles, Laurie. "Propriétés anti-athérogènes du DHA : effets nutrigénomiques au niveau aortique et rôle potentiel des métabolites issus de la peroxydation." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM17.

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Les acides gras polyinsaturés oméga-3 à longue chaîne (AGPIω3-LC), principalement représentés par l'acide eicosapentaénoïque (EPA) et l'acide docosahexaénoïque (DHA), présentent des effets bénéfiques vis-à-vis de l'athérosclérose. Leur action au niveau vasculaire est suggérée. Les mécanismes d'action sont mal compris du fait de la complexité d'action des AGPIω3-LC au niveau cellulaire. Les AGPIω3-LC affectent de nombreuses protéines y compris les facteurs de transcription, ce qui engendre la modulation de l'expression de nombreux gènes. La complexité s'accroît si l'on considère l'ensemble des
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Ma, Feng. "Clinical Assessment of Anti-Atherogenic Function of HighDensity Lipoprotein (HDL)." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS583.

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Il a été bien établi chez l’Homme qu'il existe une forte association entre les faibles concentrations plasmatiques de cholestérol associé aux lipoprotéines de haute densité (HDL-C) et le risque accru de maladie cardiovasculaire (MCV). Augmenter le taux de HDL-C a donc été proposé comme stratégie thérapeutique visant à réduire le risque de MCV. En effet, les HDL présentent de multiples fonctions athéroprotectrices, notamment la capacité d’efflux du cholestérol, ainsi que des activités antioxydantes, anti-inflammatoires, vasodilatatrices, cytoprotectrices, anti-infectieuses et anti- thrombotique
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Cavalcante, Marcela Frota. "Efeitos do fragmento variável de cadeia única anti-LDL eletronegativa vetorizado em nanocápsulas na aterosclerose experimental." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-14122016-144032/.

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As doenças cardiovasculares são a principal causa de mortalidade no mundo. A aterosclerose é a base fisiopatológica dessas doenças, sendo definida como um processo crônico-inflamatório multifatorial, resultando da interação de diferentes células como linfócitos, macrófagos, células endoteliais e células musculares lisas na parede arterial. A lipoproteína de baixa densidade eletronegativa [LDL(-)], uma subfração modificada da LDL nativa, desempenha um papel-chave na aterosclerose, uma vez que as modificações sofridas por esta partícula são capazes de induzir o acúmulo de ésteres de colesterol e
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Casas, Rodríguez Rosa Mª. "Efecto anti-inflamatorio e inmunomodulador de una intervención con dieta mediterránea sobre los marcadores de inflamación de la pared vascular y de la placa inestable. Estudio PREDIMED." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398894.

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El término arterosclerosis hace referencia a un conjunto de trastornos de las arterias caracterizados por el engrosamiento y endurecimiento de la pared arterial. Y es el resultado de dos fenómenos íntimamente relacionados: la ateromatosis, que es la acumulación lipídica focal intra y extracelular, con formación de células espumosas y reacción inflamatoria, y la esclerosis, endurecimiento cicatrizal de la pared arterial. Ross y cols. integraron ambas teorías al considerar la aterosclerosis como un proceso de respuesta inflamatorio a una agresión endotelial. Es un proceso de evolución lenta, que
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Bem, Andreza Fabro de. "Disseleneto de difenila: Um organocalcogênio com baixa toxicidade em não roedores e importantes propriedades anti-aterogênicas em modelos in vivo e in vitro." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/4444.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Atherosclerosis is a chronic inflammatory condition associated with an overproduction of oxidant species. Since low density lipoprotein (LDL) oxidation plays a key role in the pathogenesis of atherosclerosis, antioxidants that can inhibit this oxidative process might be useful in preventing atherosclerosis-related pathological conditions, such as cardiovascular diseases and stroke. Here, we investigated the potential toxicological effects and the anti-atherogenic properties of diphenyl diselenide (PhSe)2, a simple organoselenium co
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Okuda, Ligia Shimabukuro. "Albumina modificada por glicação avançada sensibiliza macrófagos à inflamação prejudicando o transporte reverso de colesterol e a atividade anti-inflamatória da HDL." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-30072012-082700/.

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No diabete melito, produtos de glicação avançada (AGE) reduzem o efluxo de colesterol celular o que agrava o desenvolvimento da aterosclerose. Neste estudo, investigou-se o papel da albumina modificada por glicação avançada (albumina-AGE) sobre a sensibilização de macrófagos à resposta inflamatória e o impacto da secreção de citocinas, quimocinas e moléculas de adesão sobre o efluxo de colesterol mediado por apolipoproteína A-I e subfrações de HDL. Além disso, determinou-se a capacidade da HDL em modular a resposta inflamatória em macrófagos tratados com albumina-AGE. Macrófagos de peritônio d
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Ying, Chih, and 朱智英. "In vitro experiments of anti-atherosclerosis by Zanthoxylum ailanthoides." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/52427009707155171158.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>93<br>Zanthoxylum ailanthoides is a medium to large tree, its leaves and bark are used as folk medicines to treat common cold and snakebite. It has been suggested that the stem components of Zanthoxylum ailanthoides possess bioactivities including anti-cancer, anti-poliferation, anti-viral, immuno-suppressive, antioxidant, anti-platelet, insecticidal, anti-inflamanatory, anti-fungal, anti-feedant and cancer preventative. In the present investigaion, the leaves of Zanthoxylum ailanthoides (ZLE) was extracted with 75% alcohol and condensed by vacuum pump. The anti-o
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Pan, Chi-hao, and 潘志豪. "Anti-Atherosclerosis Effects of Ethanol Extracts of Hericium erinaceus." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/01545307724466139906.

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碩士<br>亞洲大學<br>生物科技學系碩士班<br>101<br>In the present study, we investigated the anti-oxidant and anti-atherosclerotic effects of ethanol extracts of Hericium erinaceus (EEHE) in vitro. Atherosclerosis is the process by which an atherosclerotic lesion occurs and is induced by a complex interplays between leukocytes, endothelial cells, vascular smooth muscle cells, and cytokines in the arterial intima. Adhesion molecules of endothelial cells, such as endothelial selectin (E-selectin), vascular cell adhesion molecule-1 (VCAM-1), and intracellular adhesion molecule-1 (ICAM-1), have been reported to
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Chang, Po-Chiao, and 張博喬. "The roles of kringle proteins of human plasminogen in anti-angiogenesis and anti-atherosclerosis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/82136771295042556973.

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博士<br>國立成功大學<br>基礎醫學研究所<br>97<br>Angiogenesis plays a primary role in tumor growth and metastasis. Angiostatin, a proteolytic fragment containing the first four kringle domains of human plasminogen, can inhibit angiogenesis. The anti-angiogenic activities of kringle 1-5 (K1-5) and kringle 5 fragments of plasminogen are greater than angiostatin in inhibiting angiogenesis and angiogenesis-dependent tumor growth. To further optimize kringle fragment anti-angiogenic activities, mutations were created at the potential glycosylation sites Asn-289 and Thr-346 and the Lys binding site, Leu-532, at kri
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Shiu, Yi-Ting, and 許怡婷. "Anti-atherosclerosis Function and Machanism of Astaxanthin Using Cultured Cell model." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/35403461214593018104.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>95<br>Astaxanthin, a red-orange carotenoid pigment, is a powerful biological antioxidant and provides anti-inflammatory activities that occurs naturally in a wide variety of living organisms. Atherosclerosis is a chronic inflammation disease, it can influence human’s heath. Atherosclerosis can’t be defined as a single disease entity. Atherosclerosis possessed of the great relation with oxidative stress and inflammation had be major causes. In some early study, it shown that astaxanthin could inhibit the possession of atherosclerosis and improved plaque stability in v
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Lin, Shu-Wei, and 林書緯. "The mechanism of the anti-inflammatory and anti-atherosclerosis effect from Antrodia Salmonea and AC-0." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/20885718006413819598.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>100<br>The present study is conducted to investigate the antioxidant and anti-inflammatory potential of Antrodia Salmonea (AS) and AC-0. Our previous studies have demonstrated that AS and AC-0 exerted anti-cancer effects, however the anti-inflammatory activity and their underlying molecular mechanism are poorly understood. In this study, we investigated the anti-oxidant, anti-inflammation and anti-atherosclerotic effects of AS and AC-0 in vitro and in vivo. Treatment of AS and AC-0 caused a significant increase in anti-oxidant genes including HO-1, NQO-1, γ-GCLC and
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Liu, Shu-Lin, and 劉淑琳. "The Inhibitory Effects of Novel Anti-inflammatory Drugs on Atherosclerosis and Neointima Formation." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/20700241007527045669.

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博士<br>國立成功大學<br>基礎醫學研究所<br>95<br>Atherosclerotic vascular disease is the major cause of morbidity and mortality in many developed countries. Central to the pathogenesis of atherosclerosis is the inflammation in the arterial wall. New approaches to atherosclerosis-related diseases include novel uses of proven treatments and development of innovative agents. Statins are the most commonly prescribed agents for the treatment of hypercholesterolemia because of their efficacy in reducing low-density lipoprotein (LDL). Recent experimental and clinical evidence indicates the cholesterol-independent ef
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Kuo, Kuan-Lin, and 郭冠麟. "The Anti-inflammatory Functions of Thrombomodulin Lectin-like Domain in Sepsis and Atherosclerosis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/44748501297405545213.

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碩士<br>國立成功大學<br>醫學檢驗生物技術學系<br>94<br>Thrombomodulin (TM), a thrombin receptor on endothelial cell membrane, inhibits the procoagulant functions of thrombin and acts as a protein cofactor in thrombin-catalyzed activation of protein C. Recent studies indicate that TM not only regulates coagulation but also plays an important role in other physiological functions. Our group has found that the TM N-terminal lectin-like domain (TMD1) has unique anti-inflammatory properties. In this study, we explored the effect of TMD1 on lipopolysaccharide (LPS) and Klebsiella pneumoniae (K. pneumoniae)-induced acu
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Li, Chun-I., and 李俊毅. "Studies on the effect of water extracts of non-toxic planting Solanum nigrum in anti-LDL oxidation and anti-atherosclerosis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/78535070265321304397.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>103<br>Solanum nigrumL. is a wildherbaceous plantgrowing entire year in Taiwan. Previous reports showed it contains polyphenols and possesses the ability of anticancer and antioxidation. However, it should be overcome due to the quantity and quality of output being difficult to control. In our previous study, the resultsrevealed that the water extract of Solanum nigrumL. (SNE)have the ability of antioxidation in low density lipoprotein and anti-atherosclerosis; the mechanism might involve the inhibition of blood vessel smooth muscle cell migration. Therefore, SN h
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Rasmussen, Heather E. "Biological functions of a blue-green alga, Nostoc commune var. sphaeroides Kützing (N. commune)." 2008. http://proquest.umi.com/pqdweb?did=1622192671&sid=7&Fmt=2&clientId=14215&RQT=309&VName=PQD.

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Thesis (Ph.D.)--University of Nebraska-Lincoln, 2008.<br>Title from title screen (site viewed Mar. 31, 2009). PDF text: ix, 168 p. : ill. ; 5 Mb. UMI publication number: AAT 3331442. Includes bibliographical references. Also available in microfilm and microfiche formats.
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Giroux, Portelance Simon. "Induction d’anticorps anti-idiotypiques contre les protéoglycanes de la matrice extracellulaire dans la réduction des lésions athérosclérotiques." Thèse, 2013. http://hdl.handle.net/1866/9936.

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L’athérosclérose est caractérisée par l’accumulation de lipoprotéines de basse densité (LDL) liées aux protéoglycanes de la paroi artérielle. Des anticorps chimériques (ch) qui se lient aux glycosaminoglycanes (GAG) ont été générés. L'hypothèse est que la vaccination avec le chP3R99, un anticorps chimérique mutant de l'hybridome P3, pouvait interférer avec la rétention des LDL par l’induction d’une cascade d’anticorps anti-idiotypiques dirigés contre les GAG. Des souris mâles déficientes en apolipoprotéine E ont été soumises à une diète hypercholestérolémique et ont reçu 5 injections sous-cuta
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"Investigations of the anti-hypertensive and anti-atherosclerotic properties of danshen-gegen formula." 2010. http://library.cuhk.edu.hk/record=b5894360.

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Ng, Chun Fai.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 134-150).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Acknowledgements --- p.vii<br>Table of Contents --- p.ix<br>Abbreviations --- p.xii<br>List of Figures --- p.xv<br>List of Tables --- p.xviii<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- "Introduction to Cardiovascular Disease, Hypertension and Atherosclerosis" --- p.1<br>Chapter 1.1.1 --- Cardiovascular Disease --- p.1<br>Chapter 1.1.2 --- Hypertension --- p.2<br>Chapter 1.1.
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