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Rozprawy doktorskie na temat „Anti diabetic drugs”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Hoa, Nguyen Khanh. "Assessment of anti-diabetic effect of Vietnamese herbal drugs /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-585-2/.

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Lennox, Rachael. "Actions of anti-diabetic drugs on hippocampal dependent cognitive function in obesity and type 2 diabetes." Thesis, Ulster University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667766.

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Li, Xiaoxiao. "Ranolazine: a Potential Anti-diabetic Drug." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/19202.

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Diabetes is a life-long chronic disease that affects more than 24 million Americans. Loss of pancreatic beta-cell mass and function is central to the development of both type 1 (T1D) and type 2 diabetes (T2D). Therefore, preservation or regeneration of functional beta-cell mass is one of the essential strategies to treat diabetes [1]. In my study, I tested if ranolazine, a synthetic compound, has potential to prevent or treat diabetes. Diabetes were induced in mice by giving multiple low-doses of streptozotocin (STZ). Ranolazine was given twice daily via an oral gavage (20 mg/kg) for 5 weeks.

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Hamrén, Bengt. "Safety and Efficacy Modelling in Anti-Diabetic Drug Development." Doctoral thesis, Uppsala University, Division of Pharmacokinetics and Drug Therapy, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8648.

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<p>A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population.</p><p>Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. The aim of this thesis was to develop mechanism-based PK-PD-disease models for important safety and efficacy biomarkers used in anti-diabetic drug development. </p><p>Population PK, PK-PD and disease models were developed, based on data from clinical studies in s

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VanderMeulen, Heather. "Potential anti-inflammatory properties of the diabetic drug metformin." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123091.

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Recent studies have unveiled an anti-inflammatory property of the type 2 diabetes drug, metformin. This has been demonstrated by a decreased severity of endotoxin-induced uveitis in mice. Metformin is also shown to reduce airway remodeling and inflammation in murine models of chronic asthma. While the exact mechanism by which metformin exhibits these effects has yet to be elucidated, the biguanide drug appears to interfere with pro-inflammatory NFkB signaling. We wished to examine whether this phenomenon could be replicated in vivo in various mouse models involving both acute and chronic infla

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6

Ou, Peimian. "Possible mechanisms for oxidative damage in diabetes mellitus and of some anti-diabetes drugs." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243381.

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Craythorne, Natalie Louise. "Nanoparticles as potential drug delivery systems for anti-diabetic peptide therapeutics." Thesis, Ulster University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650084.

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Exenatide is a potent glucagon-like peptide-1 receptor agonist used in clinical practice for the management of type 2 diabetes. Exenatide is administered subcutaneously twice daily, or once weekly in the form of poly (Iactide-coglycolide) PLGA microspheres. This study investigated the benefit of using encapsulated nanoparticulate exenatide as an intraperitoneal and oral treatment compared to native peptide. To optomise the encapsulation process and determine its suitability to other peptide or protein formulations, ovalbumin and glucose-dependent insulinotrophic polypeptide (GIP) were used. Th

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Algire, Carolyn. "Impact of the anti-diabetic drug metformin on tumor growth «in vivo»." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103469.

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The prevalence of obesity is rapidly increasing in affluent countries and in many urban areas of the developing world. Epidemiologic studies have associated obesity with increased burden of many cancer types but the mechanisms by which obesity induces transformation or promotes neoplastic growth remain to be fully elucidated. Possible mediators include insulin, free fatty acids, increased bio-availability of steroid hormones and inflammation. It is important to gain better understanding of the relationship between these diseases as new insights may provide new opportunities for cancer prevent

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9

Tam, Teresa. "The effects of Cree anti-diabetic natural health products on drug metabolism and cardiomyocytes." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28230.

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Seventeen Cree anti-diabetic medicinal plant were investigated for their capacity to cause adverse effects when used as alternative or complementary medicine. Two aspects of safety were studied using their extracts: the ability to affect the contraction rate of neonatal rat cardiomyocytes in vitro to determine if the plants can influence the human heart rate, and the ability to interfere with drug metabolism by inhibiting the cytochrome P450 enzymes in vitro. The results suggest that several Cree plants may cause a harmful effect through different mechanisms. The extracts ofW2, W4, W5, and W9

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10

Gedawy, Ahmed Abou Bakr Gaber. "Innovative platforms for oral microencapsulation formulation and drug analytical techniques for anti-diabetics." Thesis, Curtin University, 2020. http://hdl.handle.net/20.500.11937/81966.

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This thesis is divided into two main sections. The first section is about developing of silicon-based pharmaceutical platform that was used to encapsulate an anti-diabetic agent (metformin). These developed microcapsules were then characterised in terms of drug content, encapsulation efficiency, flow properties and microscopical examination. The second section is about development and validation of a new HPLC analytical method for the detection and quantification of metformin and two other anti-diabetic agents that belong to sulfonylureas.

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Dang, Thuy Tram Ph D. Massachusetts Institute of Technology. "Anti-inflammatory drugs for modulation of host response to biomaterials and application in diabetes therapy." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/76482.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2012.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 95-104).<br>Host response to implanted biomaterials and medical devices poses tremendous challenges to their clinical applications. Today, the quest to mitigate this immunological attack for improved longevity of these devices remains daunting. This thesis aims to explore the use of anti-inflammatory drugs in minimizing the host response and improve the efficacy of implantable and transplantable therapeutics. Firs

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12

Odei-Addo, Frank, and Ruby-Ann Levendal. "Leonotis leonurus: understanding the mechanism of anti-diabetic action and investigating a nano drug delivery system." Thesis, Nelson Mandela Metropolitan University, 2016. http://hdl.handle.net/10948/13116.

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Diabetes mellitus is a metabolic disease characterised by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. The leaf extract of Leonotis leonurus and its active compound marrubiin, have been shown to possess anti-diabetic, antiplatelet, anti-inflammatory and anti-coagulation activity. In the present study, the mechanism by which L. leonurus and marrubiin exert their anti-diabetic properties, the cross-talk between the peripheral tissues and a nano drug delivery system were investigated. Marrubiin in the plant extract was effectively quantified by an optimised

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13

Cowan, Simone. "Anti-hypertensive drug use and the risk of serious hypoglycemia in patients with diabetes." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30840.

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Recently, there have been conflicting reports on whether anti-hypertensive medications cause serious hypoglycemia in patients with diabetes. We assessed this association using a population-based approach.<br>Utilizing the Saskatchewan Health databases, we conducted a case-control study nested within a cohort of 3639 patients with diabetes, newly prescribed angiotensin converting enzyme inhibitors (ACE-I) or dispensed other anti-hypertensive drugs during 1982 to 1987. There were 162 cases of hypoglycemia identified. All potential controls, matched to the case on entry date and at different elig

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14

Zeng, Chun. "The Role of RNASE L in Type I Diabetes and Development of Quantitative LC-MS/MS Methods for the Pharmacological Studies of Anti-Cancer Drug Candidates." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1473178407.

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15

Ghadzi, Siti Maisharah Sheikh. "Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317040.

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Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM. The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. The appropriate

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16

Tshiluka, Ndivhuwo Raymond. "Synthesis of Glitazone Analogues as Anti-Diabetic Drugs." Diss., 2018. http://hdl.handle.net/11602/1250.

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MSc (Chemistry)<br>Department of Chemistry<br>In this study, three series of novel glitazones (acetates, glycinates and alaninates) were designed and prepared by using appropriate synthetic methods to incorporate aromatic ring, alicyclic amines and alanine moiety instead of glycine moiety as a linker via two carbons. This was done over five reaction steps. Compounds were synthesized using conventional methods from step one with nucleophilic substitution to Knoevenagel condensation reaction as the final step and were characterized by using a combination of 1H NMR, 13C NMR, IR spectroscopies as

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Owonubi, Shesan John. "Development of graphene oxide-based hydrogel biocomposite with anti-diabetic activity." 2015. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001692.

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M. Tech. Polymer Technology<br>Type II diabetes afflicts more than 300 million people worldwide. The pursuit for improved targeted drug delivery systems has led to the development of highly improved biomaterials with enhanced biocompatibility and biodegradability properties. Hydrogels are of particular interest for drug delivery applications due to their ability to address targeted drug delivery, in addition to their good biocompatibility, tunable network structure needed to control the diffusion of drugs and their ability to imbibe drugs within their mesh network structure. Hydrogels are prom

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Huang, Yun-Hou, and 黃勻厚. "The Study of Anti-Diabetic Drugs Recommend System Based on Domain Ontology." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/43920607032287125955.

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碩士<br>朝陽科技大學<br>資訊管理系碩士班<br>98<br>Diabetes mellitus is one of the most common chronic diseases in recent years. According to the World Health Organization, estimated diabetic patient numbers will increase 56 percent in Asia from the year 2010 to 2025. The number of anti-diabetic drugs that doctors are able to utilize increases as the development of pharmaceutical drugs continues. Construction of diabetes medication recommendation system for doctor is necessary. Our study utilized Protégé to expand upon the interrelated information between anti-diabetic drugs knowledge and patient ontology know

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"Effects of Anti-diabetic Drugs on the Growth of Human Papillomavirus-positive Tumour in a Diabetic Mouse Model." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292636.

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"Investigation of pharmacological anti-diabetic effect on selected traditional Chinese herbs." 2005. http://library.cuhk.edu.hk/record=b5892567.

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by Lam Fung Chun.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 187-202).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Abstract in Chinese --- p.iii<br>Acknowledgements --- p.v<br>Table of Contents --- p.vi<br>List of Abbreviations --- p.xiii<br>List of Tables --- p.xvii<br>List of Figures --- p.xviii<br>Publication --- p.xx<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Epidemiology of Diabetes Mellitus --- p.1<br>Chapter 1.2 --- Definition of Diabetes Mellitus --- p.1<br>Chapter 1.3 --- G

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21

Yu-KueiLee and 李昱逵. "Comparative effectiveness research of anti-vascular endothelial growth factor drugs in diabetic macular edema." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/nfum23.

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碩士<br>國立成功大學<br>公共衛生研究所碩士在職專班<br>107<br>SUMMARY The study analyzes the patient data from the Department of Ophthalmology in National Cheng Kung University Hospital from 2015 to 2017. Three anti–vascular endothelial growth factor (anti-VEGF) medications are Lucentis (ranibizumab), Eylea (aflibercept) and Avastin (bevacizumab). The purposes of the study are comparing the effect of three anti-VEGF medications in treating the patient with diabetic macular edema, finding out the effect of drug half-life, and the possible risk factors which can influence the effect of treatment. The result showed th

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Kuo, Hung-Chih, and 郭哄志. "The Impact of NHI Drug Price Adjustment on Hospital Drug Switching and Health Care Outcome: The Case of Anti-diabetic Drugs." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/72395996966838585086.

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碩士<br>國立臺灣大學<br>健康政策與管理研究所<br>103<br>Background: Diabetes mellitus in Taiwan is common, the prevalence rate has gone up to 8%; and it has been the fourth rank of the 10 major cause of death. From 2000 to 2011, the National Health Insurance Administration in Taiwan has implemented the drug price adjustments (DPA) for seven times to control the growth of pharmaceutical expenditures. DPA may lead to changes in drug selection among hospitals. Objectives: This study intended to examine the effect of the 6th drug price adjustments in 2009 on hospital drug brand switching and health care outcome. Th

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Hui, Wing. "Development of a Novel Pck-1: eGFP Reporter Zebrafish Line for the Discovery and Evaluation of Potential Anti-Diabetic Drugs." Thesis, 2013. http://hdl.handle.net/1807/42881.

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Overexpression of Phosphoenolpyruvate carboxykinase - cytosolic (PEPCK, encoded by Pck-1 gene) has been found to be associated with the prevalence of hyperglycemia in Type 2 Diabetes Mellitus (T2DM) patients. The Pck-1 enzyme catalyzes the rate limiting step in endogenous glucose production. The aims of this study are to develop a Pck-1:eGFP reporter zebrafish and validate it as a potential tool for the screening of novel anti-diabetic compounds. 3.6 kb zebrafish Pck-1 promoter fragment was cloned and a Pck-1:eGFP expression vector was constructed. After DNA microinjection, we generated Pck-1:

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Candeias, Emanuel Monteiro. "The amazing anti-type 2 diabetic drugs in neurodegeneration: the impact of exendin-4, liraglutide and linagliptin in type 2 diabetes, Alzheimer disease and Parkinson disease." Doctoral thesis, 2021. http://hdl.handle.net/10316/98734.

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Tese de Doutoramento em Biologia Experimental e Biomedicina / área Neurociências e Doença apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra.<br>Type 2 diabetes (T2D) is a noisy “silent killer”, which has already attained the status of a global pandemic, which affects millions of people spread to every corner of the world, with the aggravating that millions more are currently living with this disease without even knowing. Even so, more efforts have to be done to the awareness, understanding and treatment of T2D in order to avoid an uncontrolled developing of l

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Lu, I.-Lin, and 呂意琳. "Structure-based drug design of anti-SARS and anti-Diabetes compounds." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/38445587232096935828.

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博士<br>國防醫學院<br>生命科學研究所<br>95<br>In this thesis, we setup the computer-aided drug design protocols for three target proteins, severe acute respiratory syndrome-coronavirus (SARS-CoV) main protease, peroxisome proliferators activated receptor-, and dipeptidyl peptidase-IV. For SARS-CoV main protease, the docking based virtual screening technique was performed. Novel non-peptide inhibitors with inhibition activity of submicro-molar range were discovered through this protocol. The structural biology study further clarify the inhibition mechanism of these compounds to SARS-CoV Mpro, which provide

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Chen, Tai-An, and 陳泰安. "A new approach to search for anti-HBV drug: to identify anti-diabetic drug, metformin, as novel class of anti-HBV therapeutics." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/25415027198321129547.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>Our laboratory has found that insulin inhibited the hepatitis B virus particles generated in the hepatoma cell line Hep3B/T2. Interestingly, the regulation of core promoter activity and transcription factors of gluconeogenesis gene expression is similar. In addition, insulin and Metformin treatment of type II diabetes through inhibition of liver gluconeogenesis. In light of this, it is therefore hypothesize that anti-diabetic drug, metformin, as novel class of anti-HBV therapeutics, by regulation of host gluconeogenesis gene expression. First, it was shown

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Chen, Szu-Kai, and 陳思凱. "Molecular Mechanism of Anti-diabetic Drug Metformin in Gastric Cancer Cell Growth." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/10973972564443098804.

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碩士<br>國立臺灣大學<br>分子與細胞生物學研究所<br>101<br>Metformin is one of the most widely used anti-diabetic drugs in type II diabetes treatment. The mechanism of lowering blood glucose is believed to be involved in suppressing hepatic gluconeogenesis, increasing muscular glucose uptake and enhancing insulin sensitivity. Recent studies suggest that metformin may reduce cancer risk, but the mechanism of anticancer action remains unclear, especially in gastric cancer. In our studies, we aim to evaluate the anticancer effects of metformin on human gastric cancer AGS cells, and use isobaric Tagging for Relative a

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MacKenzie, James. "Role of anti-hypertension class drugs in the pathogenesis of diabetes mellitus complications." Thesis, 2019. https://hdl.handle.net/2144/36583.

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The diabetic patient is subject to many complications in the event of poor control of blood glucose or blood pressure. Diabetic nephropathy is the leading cause of kidney dialysis in the developed world. Diabetic retinopathy is one of the leading causes of blindness in the United States. Cardiovascular diseases are the leading cause of morbidity in the United States. There are many different factors that predispose people to developing these conditions. Among these factors in a diabetic patient, hypertension has been shown to be strongly correlated with progression of micro and macrovascular c

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朱庭萱. "The study of the relationship among brand, channel, and price in oral anti-diabetic drug market." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/12903688065095823384.

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碩士<br>國立交通大學<br>管理學院碩士在職專班經營管理組<br>94<br>The purpose of this study is to evaluate the relationship among price, brand (whether it is brand drug or generic drug) and channels. The results of this study show that the average price of brand drugs is higher than generics and brand drugs with patent protection always enjoy higher price. From literature reviews, we can see that some brand drugs will raise their price after patent expiration because of band loyalty of prescribers. However, we didn’t observe this from our data. While healthcare environment is getting more and more competitive, brand l

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Lo, Hsin-Yi, and 羅欣宜. "Research and Development of Insulin Receptor Targeting Anti-diabetic Drug Based on Experiences of Traditional Chinese Medicine." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/k482vr.

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Tsai, Yi-Hong, and 蔡逸宏. "Pilot Investigation of A New Anti-diabetic Botanical Drug—Toona sinensis Extract Produced by Green-processed Technology." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/krxjzk.

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博士<br>高雄醫學大學<br>天然藥物研究所博士班<br>104<br>The growing population of obesity brings the increasingly serious health problems, especially on metabolic syndrome and diabetes. To neglect the unstable and sustained high blood glucose level is very easy to lead the occurrence of some fatal complications. However, many drugs and even some star products were declined progressively due to the occurrences of serious side effects during the phase IV monitored trials. In this study, we produced a supercritical fluid Toona sinensis extract, so called TS-SCF. We found that TS-SCF can improve extracellular gluco

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Chen, You-Zuo, and 陳宥佐. "Anti-diabetic drug inhibits gastric cancer cell proliferation and metastasis by regulating a novel long-non coding RNA Loc100506691." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/11648733592677447663.

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碩士<br>義守大學<br>生物科技學系<br>104<br>The long-non coding RNAs (lncRNAs) are a group of non-protein coding transcripts, which are more than 200 nucleotides in length. Accumulating evidences showed that lncRNAs play critical role in cancer progression, including cell growth, cell cycle, apoptosis and metastasis. Metformin shows the potential as a preventive and therapeutic drug for human cancers. Previous studies indicated that metformin suppressed cancer cerll growth by regulating protein coding genes and microRNAs (miRNA). However, the role of lncRNA involved in metformin-induced inhibition of cell

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Pai, Chien-Hung, and 白建宏. "A Case Study on the Marketing Strategy of SGLT-2 Anti-Diabetes Drug for a Biopharmaceutical Company." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/mzpm5q.

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碩士<br>國立交通大學<br>管理學院高階主管管理碩士學程<br>107<br>The case study in this thesis focuses a biopharmaceutical company. We are interested the marketing strategy to gain significant growth in revenue and enhance the competitive advantage for the case company. This study first accessed the environmental analysis and characteristics of biopharmaceutical industry via SWOT analysis, and then, applied Balanced Scorecard to derive the marketing strategy for the case company. We conducted thorough examination on the strategic driven factors in the framework of Balanced Scorecard (namely, financial perspective, cu

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Graham, Drew. "Endothelium-dependent vasomotor responses of hypertensive and type 2 diabetic rats: effects of sex, ageing, and therapeutic interventions." Thesis, 2009. http://hdl.handle.net/10012/4605.

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Impaired endothelial vasomotor function is a hallmark of many chronic disease states, including essential hypertension and type 2 diabetes mellitus. Loss of the homeostatic role of the endothelium in large conduit arteries can contribute to the pathogenesis of cardiovascular conditions in these vessels (e.g. stroke, atherosclerosis). A fundamental understanding of mechanisms controlling endothelial function in hypertension and type 2 diabetes mellitus is required for appropriate clinical strategies targeting the cardiovascular conditions associated with these diseases. The vast majority of

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