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Artykuły w czasopismach na temat „Anti-Synergies”

Autor: Grafiati

Data publikacji: 8 marca 2025

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1

Lombardi, Federica, Kalyan Golla, Darren J. Fitzpatrick, Fergal P. Casey, Niamh Moran, and Denis C. Shields. "Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies." PLOS Computational Biology 11, no. 4 (2015): e1004119. http://dx.doi.org/10.1371/journal.pcbi.1004119.

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Wang, Heng, and Yu Min Wang. "Study on the Tribological Performance of AlN Nanoparticles Additive." Advanced Materials Research 661 (February 2013): 33–36. http://dx.doi.org/10.4028/www.scientific.net/amr.661.33.

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By using Four-ball test machine, the anti-wear and extreme pressure performances of base oil that contain aluminum nitride (AlN) nanoparticles additive was investigated. The experimental results showed that nanoparticles additive can effectively improve extreme pressure and anti-wear performance of base oil, and the optimal concentration of it in the base oil is 3 wt%. AlN and T106 compatibility experiments showed that T106 can improve extreme pressure and anti-wear performance of AlN nanoparticles additive. Two additives have synergies to improve extreme pressure and anti-wear performance of

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Qi, Zhiwen, Chengzhang Wang, and Jianxin Jiang. "Synergies of urushiol and its pechmann derivative compatible with paclitaxel anti-HepG2 activity." Natural Product Research 33, no. 16 (2018): 2426–29. http://dx.doi.org/10.1080/14786419.2018.1446013.

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Ferreira, Wivianni Karinne Chaves, Ana Patrícia Matos Pereira, Brendha Araújo de Sousa, et al. "Chemical profile and therapeutic potential of the essential oil and nanoemulsions of Citrus x sp (Tanja Lemon)." Ciência e Natura 46 (July 29, 2024): e73722. http://dx.doi.org/10.5902/2179460x73722.

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The objective of this study was to evaluate the chemical profile and therapeutic potential of the essential oil and nanoemulsions of Citrus x sp (Tanja Lemon). Hydrodistillation was used to extract the essential oil. Gas Chromatography coupled to Mass Spectrometry (GC/MS) was used for the analysis of chemical constituents. The phenolic content (CFT) was analyzed by the Folin-Ciocalteau assay, and flavonoids (CFLT) by complexation with aluminum. The nanoemulsions were formulated by the phase inversion method. The antioxidant activity was evaluated by a hydroxyl radical assay and the anti-inflam

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Marchese, Anna, Carla Renata Arciola, Erika Coppo, et al. "The natural plant compound carvacrol as an antimicrobial and anti-biofilm agent: mechanisms, synergies and bio-inspired anti-infective materials." Biofouling 34, no. 6 (2018): 630–56. http://dx.doi.org/10.1080/08927014.2018.1480756.

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Wang, Heng. "Effect of Compatibility between AlN Nanoparticles and Borated Bis-Succinimide on Tribological Properties of Base Oil." Advanced Materials Research 952 (May 2014): 29–33. http://dx.doi.org/10.4028/www.scientific.net/amr.952.29.

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The purpose of the research was to investigate effect of compatibility between AlN nanoparticles and borated bis-succinimide on tribological properties of base oil. The load-carrying capacity and anti-wear (AW) performance of base oil that contains aluminum nitride (AlN) nanoparticles or borated bis-succinimide (T152B) additive was examined; the tribological properties of the compatibility between AlN and T152B were also examined. The experimental results showed that AlN nanoparticles additive can effectively improve load-carrying capacity and anti-wear performance of base oil. AlN nanoparticl

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Ahmed, Amr. "Insulin Sensitizers as Anti-Aging Agents: Unveiling Synergies with Albumin, GLP-1RA, Klotho Protein, and Metformin in the Quest to Combat Aging." Cell & Cellular Life Sciences Journal 9, no. 1 (2024): 1–5. http://dx.doi.org/10.23880/cclsj-16000200.

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This study delves into the synergistic interplay among albumin, insulin, Klotho protein, and relevant medications in the pursuit of a concerted approach to halt aging. Emphasizing albumin's pivotal role in various physiological functions, including transportation and drug distribution, the research underscores its decline's correlation with aging-related cognitive implications. The intricate relationship between insulin and albumin, modulated by Foxo1, underscores its crucial significance. Groundbreaking experiments, utilizing unmodified serum albumin, demonstrate a remarkable increase in life

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Yu, Xianzhe, Shan He, Jian Shen, et al. "Tumor vessel normalization and immunotherapy in gastric cancer." Therapeutic Advances in Medical Oncology 14 (January 2022): 175883592211101. http://dx.doi.org/10.1177/17588359221110176.

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Gastric cancer (GC) is a common malignant tumor, and patients with GC have a low survival rate due to limited effective treatment methods. Angiogenesis and immune evasion are two key processes in GC progression, and they act synergistically to promote tumor progression. Tumor vascular normalization has been shown to improve the efficacy of cancer immunotherapy, which in turn may be improved through enhanced immune stimulation. Therefore, it may be interesting to identify synergies between immunomodulatory agents and anti-angiogenic therapies in GC. This strategy aims to normalize the tumor mic

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Testoni, Ines, Lavinia Tredici, Gianmarco Biancalani, Mihaela Bucuţă, Maria Armezzani, and Hod Orkibi. "Anti-Violence Centers in Italy During the COVID-19 Emergency: Support Strategies for Women Victims of Violence." OBM Neurobiology 06, no. 04 (2022): 1–19. http://dx.doi.org/10.21926/obm.neurobiol.2204147.

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The COVID-19 pandemic has negatively impacted anti-violence centers for women. This study aims to investigate how the COVID-19 pandemic restrictions affect: the assistance and protection functions of the anti-violence centers; the needs of women victims of violence; and the well-being of the professionals working with these women. Twenty-four Italian anti-violence centers were involved, and 29 women working there were interviewed. From the qualitative analysis of the texts, three main themes were identified regarding the impact of the COVID-19 pandemic on the anti-violence centers service: 1)

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Tarantelli, Chiara, Lu Zhang, Elisabetta Curti, et al. "The Bruton tyrosine kinase inhibitor zanubrutinib (BGB-3111) demonstrated synergies with other anti-lymphoma targeted agents." Haematologica 104, no. 7 (2019): e307-e309. http://dx.doi.org/10.3324/haematol.2018.214759.

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Mellifont, Damian. "Taming the Raging Bully! A Case Study Critically Exploring Anti-bullying Measures to Support Neurodiverse Employees." South Asian Journal of Business and Management Cases 9, no. 1 (2019): 54–67. http://dx.doi.org/10.1177/2277977919881406.

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Disclosure of neurodiversity in the workplace can attract unfavourable attention. The aim of this case study is to critically investigate the collective potential of specialized and generic mental health promotion guides to help prevent or treat the bullying of neurodiverse employees. Applying qualitative thematic analysis to eight of these guides originating from Australia, Canada and England, this research offers three key messages that should be of interest to policymakers and practitioners working in the Asia-Pacific region and elsewhere. First, guides as reviewed by this study collectivel

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Setiawan, Iwan, Dwi Saryanti, Hazrina ., and Miftakhul Sholikhah. "Characterization and Evaluation of Anti-inflammatory Melinjo Seed Extract Nanoparticles." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 732–36. http://dx.doi.org/10.25258/ijddt.14.2.21.

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Melinjo seed extract is rich in various active compounds, including trans-resveratrol, commonly known as “melinjo resveratrol,” with antioxidant and antimicrobial pharmacological functions. However, a comprehensive exploration of the anti-inflammatory potential of melinjo seed extract has not been conducted. Converting melinjo seed extract into nanoparticles offers distinct advantages, including the ability to permeate intercellular spaces and higher cell walls through diffusion or opsonification. This flexibility allows for synergies with various technologies, presenting extensive potential f

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Li, Z., H. Zhou, Y. Lu, and T. Colatsky. "A Critical Role for Immune System Response in Mediating Anti-influenza Drug Synergies Assessed by Mechanistic Modeling." CPT: Pharmacometrics & Systems Pharmacology 3, no. 9 (2014): 135. http://dx.doi.org/10.1038/psp.2014.32.

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Friedman, Adam A., Arnaud Amzallag, Iulian Pruteanu-Malinici, et al. "Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment." PLOS ONE 10, no. 10 (2015): e0140310. http://dx.doi.org/10.1371/journal.pone.0140310.

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Wu, Na, Ningning Hu, Jinhe Wu, and Gongbo Zhou. "Tribology Properties of Synthesized Multiscale Lamellar WS2 and Their Synergistic Effect with Anti-Wear Agent ZDDP." Applied Sciences 10, no. 1 (2019): 115. http://dx.doi.org/10.3390/app10010115.

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The microscale/nanoscale lamellar-structure WS2 particles with sizes of 2 µm and 500 nm were synthesized by solid-phase reaction method and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The synergies between microscale/nanoscale WS2 particles and ZDDP as lubricating oil additives was evaluated by means of UMT-2 tribometer at room temperature. The wear scars were examined with SEM and electron-probe micro-analyzer (EPMA). The results show that the anti-wear properties were improved and the friction coefficient was greatly decreased with the simultaneous additi

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Ging, Debbie, Theodore Lynn, and Pierangelo Rosati. "Neologising misogyny: Urban Dictionary’s folksonomies of sexual abuse." New Media & Society 22, no. 5 (2019): 838–56. http://dx.doi.org/10.1177/1461444819870306.

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Web 2.0 has facilitated a particularly toxic brand of digital men’s rights activism, collectively known as the Manosphere. This amorphous network of online publics is noted for its virulent anti-feminism, extreme misogyny and synergies with the alt-right. Early manifestations of this phenomenon were confined largely to 4/Chan, Reddit and numerous alt-right forums. More recently, however, this rhetoric has become increasingly evident in Urban Dictionary. This article presents the findings of a machine-learning and manual analysis of Urban Dictionary’s entries relating to sex and gender, to asse

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Friedman, Adam A., Arnaud Amzallag, Iulian Pruteanu-Malinici, et al. "Correction: Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment." PLOS ONE 19, no. 7 (2024): e0306658. http://dx.doi.org/10.1371/journal.pone.0306658.

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Elfardi, Yahya Ramadan, Reda El Boukhari, Ahmed Fatimi, and Latifa Bouissane. "The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents." Drugs and Drug Candidates 3, no. 3 (2024): 437–54. http://dx.doi.org/10.3390/ddc3030026.

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Plants and plant extracts have long been acknowledged as valuable resources for the development of therapeutic formulations for various diseases. Among them, numerous plants and plant-derived products have demonstrated cytotoxic and/or anti-tumor properties. Saffron, particularly due to its major compounds, namely crocin, crocetin, and safranal, stands out as a promising candidate in this regard. Our research undertakes a literature review, reaffirming the antioxidant, anti-inflammatory, and, notably, anti-tumor properties of saffron and its major constituents. Additionally, this study examine

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Tajiknia, Vida, Wafik El-Deiry, Maximilian Pinho Schwermann, Lanlan Zhou, and Kelsey Huntington. "Abstract 1072: Combination of 5-Fluorouracil or ONC212 plus KRAS G12D inhibitor MRTX1133 against colorectal and pancreatic cancer cells results in immune-stimulatory cytokine patterns and unexpected synergies independent of G12D mutation." Cancer Research 83, no. 7_Supplement (2023): 1072. http://dx.doi.org/10.1158/1538-7445.am2023-1072.

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Abstract BACKGROUND: Advanced metastatic colorectal cancer (mCRC) has a 14% 5-year survival rate with little progress made for microsatellite stable tumors. KRAS mutations occur in about 40-50% of mCRC and are associated with more aggressive drug resistance and lack of response to anti-EGFR therapies. Recent advances have led to small molecules targeting KRAS G12C that have been undergoing clinical testing in lung, mCRC, and other tumor types. ONC212 is a fluorinated imipridone with strong anti-cancer activity in nM range and preclinical efficacy against pancreatic and other malignancies. Thro

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Liu, Lijian, Haihua Wang, Xixi Hao, et al. "Robust superhydrophobic bilayer coating: Long-term anti-corrosion and anti-fouling resistance enabled by POSS star cross-linking and fluoride-modified SiO2 nanoparticles specific synergies." Progress in Organic Coatings 198 (January 2025): 108919. http://dx.doi.org/10.1016/j.porgcoat.2024.108919.

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Miguel, MG, MD Antunes, and ML Faleiro. "Honey as a Complementary Medicine." Integrative Medicine Insights 12 (January 1, 2017): 117863371770286. http://dx.doi.org/10.1177/1178633717702869.

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The beneficial effects of honey on human health have long been recognized. Today, many of those positive effects have been studied to elucidate its mode of action. This review briefly summarizes the best studied features of honey, highlighting it as an appealing alternative medicine. In these reports, the health benefits of honey range from antioxidant, immunomodulatory, and anti-inflammatory activity to anticancer action, metabolic and cardiovascular benefits, prebiotic properties, human pathogen control, and antiviral activity. These studies also support that the honey’s biological activity

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Popescu, George Denis Alexandru, Cristian Scheau, Ioana Anca Badarau, et al. "The Effects of Capsaicin on Gastrointestinal Cancers." Molecules 26, no. 1 (2020): 94. http://dx.doi.org/10.3390/molecules26010094.

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Gastrointestinal (GI) cancers are a group of diseases with very high positions in the ranking of cancer incidence and mortality. While they show common features regarding the molecular mechanisms involved in cancer development, organ-specific pathophysiological processes may trigger distinct signaling pathways and intricate interactions with inflammatory cells from the tumoral milieu and mediators involved in tumorigenesis. The treatment of GI cancers is a topic of increasing interest due to the severity of these diseases, their impact on the patients’ survivability and quality of life, and th

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Thomas, Maria, Thu Hien Nguyen, Jenny Drnevich, Amber M. D’Souza, Pedro A. de Alarcon, and Manu Gnanamony. "Hu14.18K.322A Causes Direct Cell Cytotoxicity and Synergizes with Induction Chemotherapy in High-Risk Neuroblastoma." Cancers 16, no. 11 (2024): 2064. http://dx.doi.org/10.3390/cancers16112064.

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The disialoganglioside, GD2, is a promising therapeutic target due to its overexpression in certain tumors, particularly neuroblastoma (NB), with limited expression in normal tissues. Despite progress, the intricate mechanisms of action and the full spectrum of the direct cellular responses to anti-GD2 antibodies remain incompletely understood. In this study, we examined the direct cytotoxic effects of the humanized anti-GD2 antibody hu14.18K322A (hu14) on NB cell lines, by exploring the associated cell-death pathways. Additionally, we assessed the synergy between hu14 and conventional inducti

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Ravindran, Tathagatan. "Language revitalization as a postponed aspiration: anti-essentialist ethnolinguistic identity among Aymaras in Bolivia." International Journal of the Sociology of Language 2024, no. 287 (2024): 131–52. http://dx.doi.org/10.1515/ijsl-2023-0006.

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Abstract Twenty-first century Bolivia witnessed indigenous resurgence and state promotion of indigenous languages. This article ethnographically examines the impact of these processes on indigenous language revitalization and ethnolinguistic identities in urban spaces. It reveals that language attrition continues because indigenous resurgence occurred at a time when language shift from Aymara to Spanish had already occurred in most households and schools were considered the spaces for learning Aymara. Moreover, although indigenous identity continues to be linked to language, linguistic profici

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Pawaskar, Vardhana. "Effect of Mergers on Corporate Performance in India." Vikalpa: The Journal for Decision Makers 26, no. 1 (2001): 19–32. http://dx.doi.org/10.1177/0256090920010103.

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This paper studies the impact of mergers on corporate performance. It compares the pre- and post-merger operating performance of the corporations involved in merger to identify their financial characteristics. Also, the effect on merger-induced monopoly profits is identified by looking at the persistence profile of the profits. Taking a sample of 36 cases of merger between 1992 and 1995, it is seen that there are no significant differences in the financial characteristics of the two firms involved in merger. The mergers seem to lead to financial synergies and a one-time growth. The analysis of

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Mavragani, Clio P., Adrianos Nezos, Nikolas Dovrolis, et al. "Type I and II Interferon Signatures Can Predict the Response to Anti-TNF Agents in Inflammatory Bowel Disease Patients: Involvement of the Microbiota." Inflammatory Bowel Diseases 26, no. 10 (2020): 1543–53. http://dx.doi.org/10.1093/ibd/izaa216.

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Abstract Background Anti-TNF agents have been a cornerstone of IBD therapy; however, response to treatment has been variable, and clinically applicable biomarkers are urgently needed. We hypothesized that the type I and type II interferon (IFN) signatures may be a confounding factor for response to antitumor necrosis factor (TNF) treatment via interactions with the host and its gut microbiota. Methods Peripheral blood from 30 IBD patients and 10 healthy controls was subjected to real-time quantitative real-time polymerase chain reaction for type I and type II IFN genes (IFNGs), both at baselin

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Wild, Markus, Dubravka Karner, Jan Eickhoff, et al. "Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers." Pharmaceutics 15, no. 12 (2023): 2680. http://dx.doi.org/10.3390/pharmaceutics15122680.

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Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations. There is an urgent need for enhanced anti-HCMV drugs that offer improved efficacy, reduced dosages and options for long-term treatment without risk of the development of viral drug resistance. Recently, we reported the pronounced anti-HCMV efficacy of pharmacological inhibitors of cyclin-dependent kinases (CDKs), in particular, the potential of utilizing drug synergies upon combination treatment with inhibitors o

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Grazul, Magdalena, Paweł Kwiatkowski, Kacper Hartman, Anna Kilanowicz, and Monika Sienkiewicz. "How to Naturally Support the Immune System in Inflammation—Essential Oils as Immune Boosters." Biomedicines 11, no. 9 (2023): 2381. http://dx.doi.org/10.3390/biomedicines11092381.

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Efficient functionality of the immune system is needed to fight against the development of infectious diseases, including, among others, serious recurrent chronic infections. Research has shown that many modern common diseases, such as inflammatory bowel diseases and cardiovascular diseases, e.g., thromboembolism, cancer, obesity, or depression, are connected with inflammatory processes. Therefore, new, good stimulators of the immune system’s response are sought. They include synthetic compounds as well as biological preparations such as lipopolysaccharides, enzymes, bacterial metabolites, and

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Tuinstra, Jan, and Daan L. in ’t Veld. "Market-Induced Rationalization and Welfare-Enhancing Cartels." B.E. Journal of Economic Analysis & Policy 14, no. 1 (2013): 189–202. http://dx.doi.org/10.1515/bejeap-2013-0005.

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Abstract We show that incomplete cartels in quantity-setting oligopolies may increase welfare, without any efficiencies or synergies being internalized by cartel formation. The main intuition is that the cartel has an incentive to contract output and that the firms outside the cartel react to this by expanding output. If the outsiders are more efficient than the cartel firms, average production costs go down. We model collusion in a market structure with imperfect substitute goods. Even for relatively moderate differences in efficiency, total welfare may increase due to this market-induced rat

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Wang, Yawen, Yan Wen, Xiaofeng Wu, and Hongwei Cai. "Comprehensive Evaluation of GLP1 Receptor Agonists in Modulating Inflammatory Pathways and Gut Microbiota." World Journal of Innovation and Modern Technology 7, no. 6 (2024): 193–99. https://doi.org/10.53469/wjimt.2024.07(06).23.

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This study provides a detailed examination of the anti-inflammatory effects of GLP-1 receptor agonists (GLP-1RAs), employing an integrative approach that combines multi-omics analysis with in vivo and in vitro experiments. The results showed a significant decrease in pro-inflammatory cytokines (−42%±3.5%, p<0.001) alongside a notable increase in anti-inflammatory markers (+38%±4.2%, p<0.001). Additionally, the intervention induced substantial restructuring of the gut microbiota, characterized by a 2.8-fold enrichment of Faecalibacterium prausnitzii (p<0.01) and a 2.1-fold increase in

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Al-Khazaleh, Ahmad K., Xian Zhou, Deep Jyoti Bhuyan, et al. "The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects." Molecules 29, no. 2 (2024): 410. http://dx.doi.org/10.3390/molecules29020410.

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Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have received extensive scrutiny for their pharmacological properties, emerging evidence underscores the collaborative interactions among these constituents, suggesting a collective therapeutic potential. This comprehensive review explores the intricate relationships and synergies between cannabinoids, terpenes, and flavonoids in cannabis. Cannabinoids, pivotal in cannabis’s bioac

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Oksanen, Aslak-Antti. "The Indigenous Dimension of the Intersocietal: Dussel, Exteriority and the Sámi People." Millennium: Journal of International Studies 50, no. 1 (2021): 83–109. http://dx.doi.org/10.1177/03058298211050671.

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Proponents of uneven and combined development (U&CD) as a theoretical approach to International Relations (IR) have presented it as providing the conceptual means for overcoming Eurocentrism. While the U&CD scholars have made valuable contributions to anti-Eurocentric IR scholarship, this article argues that U&CD has analytical limitations that impede its anti-Eurocentric potential. These limitations derive from U&CD’s reliance on the concepts of ‘development’ and the ‘whip of external necessity’, which require developmental ranking of societies and lock U&CD into a state-c

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Uggla, Bengt Kristensson. "What Makes Us Human? The Lutheran Anthropological Link Between Wingren and Ricoeur." Open Theology 4, no. 1 (2018): 308–15. http://dx.doi.org/10.1515/opth-2018-0023.

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Abstract This paper explores the link between the extra nos in Gustaf Wingren’s theological anthropology and the homo capax in Paul Ricoeur’s philosophical anthropology, considered as two creative receptions of the tradition from Luther. I will argue that the reason that we find such synergies between these two thinkers, even though neither of them ever referred to the other, has to do with their common roots in, and their contributions to rethink, the tradition from the Reformation. Wingren takes his specific place in twentieth century theology as an angry critic of the dominant anti-liberal

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Carroll, Natalie, Reneau Youngblood, Alena Smith, Ana-Maria Dragoi, Brian A. Salvatore, and Elahe Mahdavian. "TNBC Therapeutics Based on Combination of Fusarochromanone with EGFR Inhibitors." Biomedicines 10, no. 11 (2022): 2906. http://dx.doi.org/10.3390/biomedicines10112906.

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Fusarochromanone is an experimental drug with unique and potent anti-cancer activity. Current cancer therapies often incorporate a combination of drugs to increase efficacy and decrease the development of drug resistance. In this study, we used drug combinations and cellular phenotypic screens to address important questions about FC101′s mode of action and its potential therapeutic synergies in triple negative breast cancer (TNBC). We hypothesized that FC101′s activity against TNBC is similar to the mTOR inhibitor, everolimus, because FC101 downregulates the phosphorylation of two mTOR substra

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Torne, Sangmesh, A. Sheela, and N. C. Sarada. "Investigation of the Role of the Alkalizing Agent in Sodium Alginate Liquid Anti-reflux Suspension." Current Drug Therapy 15, no. 1 (2020): 53–60. http://dx.doi.org/10.2174/1574885514666190103140951.

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Background: Anti-reflux formulation is one of the popular formulations across the globe in the pharmaceutical industry used specifically for the management of gastro-oesophageal reflux disease. But, this formulation is less explored with respect to research. Anti-reflux formulation has challenges to show its antacid functionality, which could have synergies in the management of refluxes in gastro-oesophageal reflux disease. Alkalizing agents act as antacid and improve the acid neutralization capacity in the anti-reflux formulation, and can be used appropriately as they affect raft strength bey

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Hajareh Haghighi, Farid, Roya Binaymotlagh, Ilaria Fratoddi, Laura Chronopoulou, and Cleofe Palocci. "Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery." Gels 9, no. 12 (2023): 953. http://dx.doi.org/10.3390/gels9120953.

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Cancer is the second leading cause of death globally, but conventional anticancer drugs have side effects, mainly due to their non-specific distribution in the body in both cancerous and healthy cells. To address this relevant issue and improve the efficiency of anticancer drugs, increasing attention is being devoted to hydrogel drug-delivery systems for different kinds of cancer treatment due to their high biocompatibility and stability, low side effects, and ease of modifications. To improve the therapeutic efficiency and provide multi-functionality, different types of nanoparticles (NPs) ca

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Grant, Rainer, Marco Pinheiro, Rachel Weller Roska, and Robert Felix. "Abstract 943: Identification and validation of unusual drug combinations identified from combination databases." Cancer Research 84, no. 6_Supplement (2024): 943. http://dx.doi.org/10.1158/1538-7445.am2024-943.

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Abstract There is a noted trend in the identification and subsequent approval of rational drug combinations to treat various diseases, particularly cancer. When applied in a clinical setting, synergistic combinations can have significant benefits including improved patient response and avoiding or overcoming drug resistance. Although multiple strategies have been successfully implemented to identify rational drug combinations, extensive validation is initially required to confirm a combination as synergistic. The existence and growing use of web-based repositories containing comprehensive drug

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Lazzaro, Brian P., Michael Zasloff, and Jens Rolff. "Antimicrobial peptides: Application informed by evolution." Science 368, no. 6490 (2020): eaau5480. http://dx.doi.org/10.1126/science.aau5480.

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Antimicrobial peptides (AMPs) are essential components of immune defenses of multicellular organisms and are currently in development as anti-infective drugs. AMPs have been classically assumed to have broad-spectrum activity and simple kinetics, but recent evidence suggests an unexpected degree of specificity and a high capacity for synergies. Deeper evaluation of the molecular evolution and population genetics of AMP genes reveals more evidence for adaptive maintenance of polymorphism in AMP genes than has previously been appreciated, as well as adaptive loss of AMP activity. AMPs exhibit ph

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Bogoslovskaya, Galina. "Peritoneal Tuberculosis Presenting as Chronic Ascites with Scrofula: A Case Report." Cardiology Research and Reports 6, no. 4 (2024): 01–05. http://dx.doi.org/10.31579/2692-9759/137.

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Bacteria are one of the factors that cause skin infections. Staphylococcus aureus was the most prevalent type, and because of the frequent use of antibacterial, many of them have become resistant. From this principle, this study was conducted at the Faculty of Medical Technology, Islamic University, from January 2023 to May 2023, and the aim of the study is to investigate and detect bacteria that cause skin infections and test the antifungal synergy of with the antibacterials. the results show (Staphylococcus aureus 45%, Escherichia coli,35%, pseudomonas aeruginosa 8%, Staphylococcus epidermid

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Olejnik, Anna, Justyna Gornowicz-Porowska, Dorota Jenerowicz, et al. "Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review." Nutrients 15, no. 17 (2023): 3857. http://dx.doi.org/10.3390/nu15173857.

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Recently, the prevalence of atopic dermatitis has increased drastically, especially in urban populations. This multifactorial skin disease is caused by complex interactions between various factors including genetics, environment, lifestyle, and diet. In eczema, apart from using an elimination diet, the adequate content of fatty acids from foods (saturated, monounsaturated, and polyunsaturated fatty acids) plays an important role as an immunomodulatory agent. Different aspects regarding atopic dermatitis include connections between lipid metabolism in atopic dermatitis, with the importance of t

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Tan, Jiacheng. "The Emerging Role of Engineering Immune Cells in Cancer Treatments." Highlights in Science, Engineering and Technology 54 (July 4, 2023): 246–56. http://dx.doi.org/10.54097/hset.v54i.9775.

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Cell-based immunotherapy has become one of the forefronts of cancer treatments and led to significant clinical success in multiple refractory/recurrent hematological malignancies. Compared with other conventional treatment approaches, engineered immune cells are considered “living factories” that are able to continually produce anti-tumor factors and have the potential to mediate long-lasting therapeutic benefits following a single application. The intrinsic ability to expand and respond in portion to needs encompasses this technology a greater and more transformative potential to enable a mor

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Kusuma, Ikhwan Yuda, Habibie Habibie, Muh Akbar Bahar, Ferenc Budán, and Dezső Csupor. "Anticancer Effects of Secoiridoids—A Scoping Review of the Molecular Mechanisms behind the Chemopreventive Effects of the Olive Tree Components Oleocanthal, Oleacein, and Oleuropein." Nutrients 16, no. 16 (2024): 2755. http://dx.doi.org/10.3390/nu16162755.

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The olive tree (Olea europaea) and olive oil hold significant cultural and historical importance in Europe. The health benefits associated with olive oil consumption have been well documented. This paper explores the mechanisms of the anti-cancer effects of olive oil and olive leaf, focusing on their key bioactive compounds, namely oleocanthal, oleacein, and oleuropein. The chemopreventive potential of oleocanthal, oleacein, and oleuropein is comprehensively examined through this systematic review. We conducted a systematic literature search to identify eligible articles from Scopus, PubMed, a

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Wu, Tsai-Yi, Kun-Hua Tu, Kung-Wei Lin, Jhan-Jie Peng, Han-Po Shih, and Cheng-Lung Ku. "The pathogenic anti-PLA2R autoantibodies cooperatively elicit the activation of complement in primary membranous nephropathy." Journal of Immunology 210, no. 1_Supplement (2023): 247.05. http://dx.doi.org/10.4049/jimmunol.210.supp.247.05.

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Abstract Primary membranous nephropathy (pMN) is an autoimmune disease associated with autoantibody-mediated immune complexes and the deposition of activated complement proteins on the glomerulus. The phospholipase A2 receptor 1 (PLA2R) has been identified as a major antigen for autoantibodies in 80% of pMN patients. Antibodies of IgG1 and IgG3, but not IgG4, can activate complement. Unexpectedly, in pMN patients, the PLA2R autoantibodies are IgG4 predominance, and those of IgG1 and IgG3 are less abundant in the affected tissues, arguing the role of PLA2R autoantibodies in the pathologies of p

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Visan, Diana-Carolina, Eliza Oprea, Valeria Radulescu, et al. "Original Contributions to the Chemical Composition, Microbicidal, Virulence-Arresting and Antibiotic-Enhancing Activity of Essential Oils from Four Coniferous Species." Pharmaceuticals 14, no. 11 (2021): 1159. http://dx.doi.org/10.3390/ph14111159.

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This study aimed to establish the essential oil (EO) composition from young shoots of Picea abies, Larix decidua, Pseudotsuga menziesii, and Pinus nigra harvested from Romania and evaluate their antimicrobial and anti-virulence activity, as well as potential synergies with currently used antibiotics. The samples’ EO average content varied between 0.62% and 1.02% (mL/100 g plant). The mono- and sesquiterpene hydrocarbons were dominant in the composition of the studied EOs. The antimicrobial activity revealed that the minimum inhibitory concentration (MIC) values for the tested EOs and some pure

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Rusetiyanti, Nurwestu. "Insight of PrEP and Testing STI Puzzle." Academic Hospital Journal 3, no. 01 (2021): 30. http://dx.doi.org/10.22146/ahj.v3i01.58770.

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Pre Exposure Prophylaxis (PrEP) is the use of Anti Retroviral (ARV) drugs by HIV-uninfected people to block the acquisition of HIV before exposure to HIV. There are concerns that PrEP introduction and scale up may pose risks, such as sexual behavior change in specific populations, and have an impact on the budget in already constrained health systems. Therefore, public health measures for the prevention of HIV and other STIs need to be enhanced, such as the prioritization of PrEP, coupled with more effective STI screening and treatment. Integration of STI and PrEP programmes can be viewed bi-d

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Liu, Naiming, Depeng Chu, Xianlin Chen, et al. "A Spray-On Microemulsion with Mold-Proof Effect on Paper." Coatings 13, no. 4 (2023): 745. http://dx.doi.org/10.3390/coatings13040745.

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Archives, ancient books, and documents kept in museums and libraries are the carriers of historic and cultural information left by our ancestors. However, these paper cultural relics can show notorious signs of degradation, e.g., fungal development. Due to the organic components of paper objects, they suffer from fungal biodeterioration. The excreted substances of fungi and the fungi’s structures themselves are often colored and interfere with the readability of the artifacts, diminishing their artistic and monetary values. In this study, we collected and separated the moldy archives collected

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Israeli-Korn, Simon D., Avi Barliya, Caroline Paquette, et al. "Intersegmental coordination patterns are differently affected in Parkinson’s disease and cerebellar ataxia." Journal of Neurophysiology 121, no. 2 (2019): 672–89. http://dx.doi.org/10.1152/jn.00788.2017.

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The law of intersegmental coordination (Borghese et al. 1996) may be altered in pathological conditions. Here we investigated the contribution of the basal ganglia (BG) and the cerebellum to lower limb intersegmental coordination by inspecting the plane’s orientation and other parameters pertinent to this law in patients with idiopathic Parkinson’s disease (PD) or cerebellar ataxia (CA). We also applied a mathematical model that successfully accounts for the intersegmental law of coordination observed in control subjects (Barliya et al. 2009). In the present study, we compared the planarity in

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Zhang, Yiqun, and Wafik S. El-Deiry. "Abstract 2671: Imipridones ONC201 and ONC206 reduce expression of neogenin and EZH1/2 which correlate with synergy following their combination with EZH1/2 or HDAC inhibitors in treatment of DMG and other tumors." Cancer Research 83, no. 7_Supplement (2023): 2671. http://dx.doi.org/10.1158/1538-7445.am2023-2671.

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Abstract Imipridones are a family of small molecule compounds including ONC201, ONC206 and ONC212 with anti-cancer activity mediated in part through activation of the integrated stress response, induction of TRAIL and its receptor, DR5, and activation of mitochondrial caseinolytic protease ClpP with consequent impairment of oxidative phosphorylation. Early clinical data have indicated that ONC201 provides clinical benefit in a subset of patients with histone H3K27M-mutated diffuse midline glioma (DMG). The H3K27M mutation prevents the function of EZH2 in methylating H3K27 on the mutated protei

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Gusmão, Camilla Teixeira Pinheiro. "Evaluation of the effects of essential oils on the reduction of stress: a rapid narrative review." Brazilian Journal of Health Aromatherapy and Essential Oil 1, no. 1 (2024): bjhae4. http://dx.doi.org/10.62435/2965-7253.bjhae.2024.bjhae4.

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The present narrative review focuses on exploring the role of essential oils as a significant intervention in stress management. Stress, defined as an adaptive response to challenging stimuli, manifests in various spheres, with its approach being essential for the preservation of physical and emotional well-being. Essential oils present themselves as bioactive agents whose impact occurs on the nervous system through olfactory and cutaneous pathways, directly influencing emotional processes, memories, mood, and behavior. Notable among these essential oils are lavender, chamomile, and bergamot,

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Santos, Elisama Ribeiro dos. "Aromatherapy for Unifocal Alopecia Areata and Dermatitis: A Case Report." Brazilian Journal of Health Aromatherapy and Essential Oil 1, no. 1 (2024): bjhae5. http://dx.doi.org/10.62435/2965-7253.bjhae.2024.bjhae5.

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The present narrative review focuses on exploring the role of essential oils as a significant intervention in stress management. Stress, defined as an adaptive response to challenging stimuli, manifests in various spheres, with its approach being essential for the preservation of physical and emotional well-being. Essential oils present themselves as bioactive agents whose impact occurs on the nervous system through olfactory and cutaneous pathways, directly influencing emotional processes, memories, mood, and behavior. Notable among these essential oils are lavender, chamomile, and bergamot,

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