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Rozprawy doktorskie na temat „Antibody recognition”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 8 lutego 2022

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1

Bristow, Richard G. W. "Antibody recognition of HIV-1 glycoproteins." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315370.

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Davies, Julian. "Antibody VH domains as small recognition units." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263483.

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Robakiewicz, Stefania. "Minimal structural glyco-epitope for antibody recognition." Thesis, Lille 1, 2020. http://www.theses.fr/2020LIL1S101.

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L'importance biologique de la glycosylation pour la santé et la maladie est largement reconnue. Les structures tronquées à terminaison mannose consistant en 1 à 3 résidus de mannose, deux N-acétylglucosamines et un nombre variable de fragments fucose sont appelées paucimannose. Les N-glycanes paucimannosidiques sont abondamment exprimés dans les plantes et les invertébrés. Cependant, chez les vertébrés, leur présence est limitée à certaines conditions pathophysiologiques, telles que le cancer, les troubles immunitaires, les infections et l'inflammation, et chez les individus en bonne santé, il

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4

Scherer, Erin M. "Antibody recognition of a protein epitope close to a membrane : a novel solution." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510216.

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5

Webster, Duncan F. "Characterisation of human hepatic cytochrome P450 : comparison of metabolic markers and antibody recognition." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU530008.

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A cDNA library was produced in lambdagt11 from an induced human liver. Twenty-one clones were isolated. All clones were identified by two of the four antibodies used in the screening process. The phage insert was recovered by PCR with two specific primers. The PCR product was ligated into M13 vectors and sequenced. The DNA was a CYP2A sequence with highest identity to CYP2A6 but contained a point deletion mutation. Coumarin metabolism was measured in microsomal preparations of fifteen livers and was inhibited by three of the antibodies used in screening. RP1 monoclonal gave partial inhibition

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6

Raina, Monika. "Development of an impedimetric biosensor using a non-antibody based biological recognition molecule." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6844/.

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The molecular recognition layer generally immobilised on the active interface of a biosensor is one of the key factors in governing the biosensor’s performance, and in particular its sensitivity and selectivity. The aim of this thesis was to investigate a novel non-immunoglobulin-based recognition molecule as the capture molecule for electrochemical biosensors with the aim to improve sensitivity and specificity of label-free biosensing. To understand the characteristics of the biomolecular layer of a biosensor formed from the non-immunoglobulin-based recognition molecule, the Adhiron scaffold

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7

Topping, Katherine P. "Structural studies on serotype-specific opsonic antibody recognition of protective streptococcal M protein epitopes." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294877.

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8

Koh, W. W. L. "Characterisation of subtype C HIV-I envelope glycoproteins and their recognition by llama antibody fragments." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18999/.

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Subtype C HIV-1 is currently responsible for the majority of new infections in the world, particularly in parts of Africa where the adult prevalence rate is as high as 15%. In the absence of a viable vaccine in the near future, the study of new neutralising antibodies that can inhibit virus entry is urgently needed. To understand the subtype C HIV-1 envelopes, the env gene was cloned directly from 15 patient plasma samples obtained from a few countries in Africa and in the UK, and 18 replication-competent chimeric viruses were created. These envelopes were then characterised and compared with

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9

Naqid, Ibrahim. "Investigation of antibody-based immune recognition of infections with Salmonella enterica serovars Typhimurium and Enteritidis." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33141/.

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Salmonellosis causes significant economic losses to the pig and poultry industries. Pigs and chickens are also a significant source of Salmonella for humans, usually transmitted through the consumption of Salmonella contaminated chicken and pork products. Predominantly, Salmonella enterica serovar Typhimurium and Enteritidis remain a global health problem. Probiotics and prebiotics have been previously used as alternatives to antibiotic treatments in the protection against enteropathogens including S. Typhimurium. Here, we determined the effects of probiotic, prebiotic and synbiotic diets on h

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10

Grinstead, Jeffrey Scott. "Structural immunology of humoral and cellular recognition of a MUC1 breast cancer antigen /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8180.

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11

Ting, Joy Holtvluwer. "Molecular ecology of mate recognition in the harpacticoid copepod Tigriopus : antibody production, protein purification, and fitness consequences." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/25202.

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12

Wang, Hongsheng. "Natural antibody recognition, signaling and surveillance in v-Ha-ras- and PKC-ß1-overexpressing 10T1/2 fibroblasts." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0003/NQ32033.pdf.

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13

Madigan, Judith. "Antibody and T-Cell recognition of MHC- and mimicking tissue-peptides in autoimmune disease, particularly ankylosing spondylitis." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444151.

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14

Al, Qaraghuli Mohammed. "Investigating the antibody recognition of different hapten classes using a combination of phage display and protein modelling." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=214816.

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15

Easton, Donna Meredith, and n/a. "Functional and Antigenic Characterisation of the Moraxella catarrhalis protein M35." University of Canberra. n/a, 2008. http://erl.canberra.edu.au./public/adt-AUC20081217.083105.

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This thesis reports the characterisation of a novel outer membrane protein (OMP) from M. catarrhalis, designated M35, with a molecular mass of 36.1 kDa. This protein is structurally homologous to classic Gram-negative porins, such as OMP C from E. coli and OMP K36 from K. pneumoniae, with a predicted structure of 8 surface loops connecting 16 antiparallel -sheets. Comparison of the DNA sequences of the M35 genes from 18 diverse clinical isolates showed that the gene was highly conserved (99.6-100 % of nucleotides) with only one isolate (ID78LN266) having base variations that resulted in amino

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16

Rogers, Todd H. "Receptor recognition and response of dendritic cells to biomaterials." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37107.

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The goal of the work presented was to further understand how both the body and dendritic cells (DCs) interact and respond to biomaterials through receptor-mediated mechanisms. The role of Toll-like receptor 4 (TLR4) was investigated in the host response to biomaterials, and it was found that TLR4-deficient mice (in comparison to wild-type) had a delayed acute inflammatory response as seen through an altered adherent leukocyte profile on implanted polymer discs. However, following a 2 week implantation, the response was resolved potentially through compensatory receptors. Therefore, TLR4 may ai

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17

Writer, Michele. "Molecular analysis of the recognition of the tumour associated antigen CD55 by the mouse monoclonal antibody 791T/36." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342476.

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18

Meng, Guangxun. "Cellular recognition of microbial patterns through toll-like receptor (TLR) 2 analysis of molecular requirements and monoclonal antibody mediated blockage /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973389672.

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19

Diestel, Uschi [Verfasser], та Yves A. [Akademischer Betreuer] Muller. "Structural Basis for TGF-β-Receptor Interaction and Antibody Recognition of HCMV Envelope Protein gB / Uschi Diestel. Gutachter: Yves A. Muller". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1075832683/34.

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20

Otali, Dennis. "The combined effect of formalin fixation and individual steps in tissue processing on immunorecognition." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/otali.pdf.

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21

Panagiotopoulou, Maria. "Organic-inorganic composite materials for specific recognition and optical detection of environmental, food and biomedical analytes." Thesis, Compiègne, 2016. http://www.theses.fr/2016COMP2315/document.

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Cette thèse décrit l'état de l'art des sondes et nanoparticules fluorescents traditionnels utilisés en imagerie de fluorescence ainsi que le développement de nouveaux nanomatériaux à base de polymère à empreinte moléculaire, aussi dénommé ‘anticorps plastique’, pour le ciblage et la bioimagerie. En biologie et en médecine, il y a un besoin constant de diagnostiquer diverses maladies pour leur éventuel traitement et prévention. Une distribution anormale et un taux élévé de glycosylation (e.g. acides hyaluronique et sialique) à la surface ou dans les cellules sont indicateurs d’une infection ou

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22

Joel, Smita. "ENGINEERING PROTEINS WITH UNIQUE CHARACTERISTICS FOR DIAGNOSTICS AND BIOSENSORS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/180.

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Proteins possess a broad range of structural and functional properties and, therefore, can be employed in a variety of biomedical applications. While a good number of protein-based biosensing systems and biosensors for target analytes have been developed, the search for versatile, highly sensitive and selective sensors with long term stability able to provide fast detection of target analytes continues to be a challenge. To that end, we now report the design and development of modified proteins with tailored characteristics and their further utilization in the development of biosensing systems

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23

Lamendour, Lucille. "Modulation des fonctions des cellules dendritiques humaines par des fragments d'anticorps." Thesis, Tours, 2018. http://www.theses.fr/2018TOUR3303/document.

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Le système immunitaire protège un organisme du développement de pathogènes et participe activement au maintien de la tolérance immunitaire. Les cellules dendritiques (DC) sont des cellules spécialisées dans l’équilibre pro et anti-inflammatoire de la réponse immunitaire. Les DC jouent un rôle important dans de nombreux contextes pathologiques notamment la transplantation d’organes, en oncologie et dans les pathologies inflammatoires. Elles sont modulables grâce à divers facteurs, intrinsèques et extrinsèques. Parce qu’elles sont capables d’induire une réponse tolérogène, ces cellules représent

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24

Martí, Fernández Iris [Verfasser], and Wolfang [Akademischer Betreuer] Enard. "Antibodies to myelin oligodendrocyte glycoprotein (MOG): Analysis of the impact of the glycosylation site of MOG for recognition of human autoantibodies and dissection of effector functions of the anti-MOG monoclonal antibody 8-18C5 / Iris Martí Fernández ; Betreuer: Wolfang Enard." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1227840047/34.

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25

Belot, Laura. "Etude structurale et fonctionnelle de la glycoprotéine des Rhabdovirus Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein Structural and cellular biology of rhabdovirus entry Monomeric Intermediates Formed by Vesiculovirus Glycoprotein during Its Low-pH-induced Structural Transition." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS522.

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Les Rhabdovirus sont des virus enveloppés à ARN simple brin de polarité négative. Ils possèdent une unique protéine transmembranaire à leur surface, la glycoprotéine G. G est impliquée dans les étapes précoces du cycle viral. G lie dans un premier temps un récepteur cellulaire, menant à l’endocytose du virus. Ensuite, G orchestre la fusion membranaire entre les membranes virale et endosomale. Cette fusion membranaire permet la libération du génome viral dans le cytoplasme de la cellule infectée.Le récepteur des lipoprotéines de basse densité (LDLR) est le récepteur principal du VSV. L’ectodoma

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26

Chauvet, Margaux. "Étude de la modulation, par l'hémoglobine S, de la présentation des antigènes plasmodiaux à la surface du globule rouge infecté par Plasmodium falciparum, et de la réponse immunitaire contre le paludisme Impact of hemoglobin S trait on cell surface antibody recognition of Plasmodium falciparum infected erythrocytes in pregnancy-associated malaria." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB037.

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Le paludisme est une maladie tropicale résultant de l'infection par le parasite Plasmodium falciparum transmis par piqûre de moustique. Les symptômes du paludisme résultent du développement de P. falciparum dans les globules rouges (GR). Depuis des siècles, le paludisme a exercé des pressions sur le génome humain, sélectionnant des mutations conférant une protection contre les formes sévères de la maladie. C'est le cas de la mutation du gène de l'hémoglobine (HbA), composant principal des GRs. La forme mutée du gène produit une hémoglobine anormale (HbS). Contrairement à la drépanocytose (HbSS

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27

Santoro, Lyse. "Appretement et présentation d'un anticorps monoclonal murin par une lignée monocytaire ou lymphocytaire B humaine : influence de la liaison covalente entre anticorps et fragment C3b du complément." Grenoble 1, 1994. http://www.theses.fr/1994GRE10126.

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La proteine c3 du complement influence l'elaboration de la reponse immune specifique dirigee contre un antigene defini. L'etude presentee dans cette these contribue a demontrer que le fragment c3b du complement, en se fixant de facon covalente a un antigene d'origine exogene, module l'appretement de l'antigene par une cellule presentatrice de l'antigene. Des donnees bibliographiques recentes concernant l'appretement d'antigenes, le fragment c3b et son implication dans la reponse immune specifique sont presentees dans un chapitre d'introduction. L'etude experimentale decrite a ete realisee en u

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Parker, Matthew J. "Protein recognition of clinically-relevant carbohydrates." Thesis, 2015. http://hdl.handle.net/1828/6264.

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A diverse array of proteins has evolved to detect and affect carbohydrate structures, thereby performing critical roles in important biological events. Carbohydrate recognition usually employs a high degree of precision, as discriminating between two carbohydrate structures can depend on a single hydrogen bond or the configuration of a hydroxyl group. My work has focused on the molecular recognition of carbohydrate antigens by two biologically important classes of carbohydrate-binding proteins: antibodies and lectins. Single crystal x-ray diffraction has been employed to study the IgG2a antibo

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Cobaugh, Christian Wessel 1971. "Single scaffold antibody libraries created with high rates of mutagenesis or diversity focused for peptide recognition." 2007. http://hdl.handle.net/2152/15990.

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This dissertation describes several strategies used to create diversity in non-immune antibody libraries. Two of the strategies were used to create two separate peptide focused libraries. Both of these strategies used to create these antigen-class focused libraries used a single scaffold antibody gene that contained diversity only in the variable heavy region. The scaffold antibody gene one of the libraries, the M:anti-pep library, was chosen based on hypervariable loop canonical structures that are characteristic of other anti-peptide antibodies. Additionally, all of the contact residues

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30

Wolf, Cornel [Verfasser]. "Structured antibody surfaces for bio-recognition and a label-free detection of bacteria / Cornel Wolf." 2010. http://d-nb.info/1009999826/34.

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31

Agnew, Heather Dawn. "Rapid Construction of Protein Capture Agents with Chemically Designed Stability and Antibody-Like Recognition Properties." Thesis, 2010. https://thesis.library.caltech.edu/5583/11/Thesis.pdf.

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<p>This thesis describes technologies for the rapid and scalable production of high-affinity, high-specificity protein capture agents which possess the affinities and specificities of antibodies, but also exhibit improved chemical, biochemical, and physical stability. I will discuss how the chemical flexibility of comprehensive, one-bead-one-compound (OBOC) libraries of oligopeptides may be combined with iterative in situ click chemistry to select multi-ligand capture agents. Large OBOC libraries form the basis of individual peptide ligands, and also permit chemically designed stability thro

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32

Yu-Ming, Wang. "Specific Recognition Force, Dissociation and Thermodynamics of Single-pair Antibody-Antigen Interaction Using Atomic Force Microscopy." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1110200612471100.

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33

Wang, Yu-Ming, and 王裕銘. "Specific Recognition Force, Dissociation and Thermodynamics of Single-pair Antibody-Antigen Interaction Using Atomic Force Microscopy." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/32594189490753914708.

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博士<br>國立臺灣大學<br>應用力學研究所<br>95<br>Molecular recognition and intermolecular binding are essential for implementing many biochemical and biological processes in living organisms. To further understand the molecular binding mechanisms, this study used atomic force microscopy as a force-based senor for investigation of the force strength between antibody and antigen complex in a single pair level with varied physiological (pH and temperature) and physical (loading rate) conditions. The results provided direct evidence of unbinding force, dissociation rate and thermodynamic parameters that explained

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34

Wang, Hongsheng. "Natural antibody recognition, signaling and surveillance in v-Ha-ras- and PKC-B1-overexpressing 10T1/2 fibroblasts." 1998. http://hdl.handle.net/1993/1574.

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Extensive evidence supports a role for polyclonal serum natural antibody (NAb) acting as a mediator of natural resistance against tumors in mice. However, little is known about its mechanisms of action or about the phenotype of susceptible cells. C3H 10T${1\over 2}$ fibroblasts overexpressing an activated ras oncogene or a PKC-$\beta$1 gene increased their NAb binding capacities, identifying PKC, an integral signaling molecule of normal cellular activation, as a key regulator of NAb binding structures. This, coupled with corresponding decreases in expression of membrane PKC-$\alpha$ and NAb bi

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Kuo, Ting Yu, and 郭庭佑. "A study of antibody X in the recognition of Helicobacter pylori neutrophil-activating protein as a new antigen." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/15235655246083217830.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>104<br>Helicobacter pylori (H. pylori) is a major pathogen involved in gastritis, peptic ulcer disease, and gastric cancer. Helicobacter pylori neutrophil-activating protein (HP-NAP) is an important virulence factor of H. pylori. The inflammation of the gastric mucosa caused by H. pylori infection might be resulted from the cytokines and reactive oxygen species (ROS) produced by HP-NAP-stimulated human leukocytes. Thus, H. pylori-induced inflammation of the gastric mucosa could be attenuated by blocking the activity of HP-NAP. Here, I found that antibody X not

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36

Meng, Guangxun [Verfasser]. "Cellular recognition of microbial patterns through toll-like receptor (TLR) 2 : analysis of molecular requirements and monoclonal antibody mediated blockage / Guangxun Meng." 2004. http://d-nb.info/973389672/34.

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