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Artykuły w czasopismach na temat „Antihyperlipidemia”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Raharjo, Danang, Anna Fitriawati, and Muhhamad Aminnulloh. "AKTIVIITAS ANTIOKSIDAN ANTIHIPERLIPIDEMIA DAN ANTIHIPERTENSI DARI EKSTRAK ETANOL DAUN KEDABU (Sonneratia ovata. Backer)." JIIS (Jurnal Ilmiah Ibnu Sina): Ilmu Farmasi dan Kesehatan 10, no. 1 (2025): 67–79. https://doi.org/10.36387/jiis.v10i1.2245.

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Kedabu (Sonneratia ovata. Backer) is one type of mangrove from the genus Sonneratia with high flavonoid content that has the potential as an antioxidant. The flavonoid content in the kedabu plant includes sonnerphenolic, vanillin, (-)-(R)-nyasol, (-)-(R)-4’-O-methylnyasol, maslinic acid, lingueresinol and gallic acid. Flavonoids as antioxidants can improve blood lipid profiles by lowering total cholesterol, triglycerides, and LDL, and increasing HDL. In addition, flavonoids can inhibit the activity of Angiotensin-converting enzyme (ACE) so that it has the potential as an antihypertensive. This

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Gultom, Evi Depiana. "Hiperlipidemia Uji Efektivitas Antihiperlipidemia Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Pada Tikus Putih Jantan Yang Di Induksi Fruktosa." Jurnal Penelitian Farmasi & Herbal 7, no. 1 (2024): 25–35. https://doi.org/10.36656/jpfh.v7i1.1985.

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Hyperlipidemia is a condition of high lipid concentration which is characterized by increased concentrations of triglycerides, LDL (Low Density Lipoprotein), blood cholesterol that exceeds normal limits which is one of the risk factors for cardiovascular disease. Kersen leaf has contains secondary metabolites of flavonoids and saponins which are thought to reduce cholesterol levels in the blood. The aim of this study was to determine the antihyperlipidemic effectiveness of ethanol extract of kersen leaf (EEDK/EEKL) in fructose-induced male white rats. Testing the effectiveness of antihyperlipi

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Dewi, Rika Sari, Ni Made Dwi Sandhiutami, Dea Anisa Sarsono, and Doreensia Putri Cuinita. "Antioxidants and Antihyperlipidemia Test of Ethanol Extract of Indonesian Plant Sambang Getih Leaves (Hemigraphis Bicolor Boerl.) In Hyperlipidemia Mice." Open Access Macedonian Journal of Medical Sciences 11, A (2023): 92–98. http://dx.doi.org/10.3889/oamjms.2023.10962.

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AIM: Sambih getih leaves (SGL) contain flavonoids acting as an antioxidant and antihyperlipidemia. The purpose of this study is to determine the antioxidant activity and antihyperlipidemia effect of Ethanol Extract of Sambang Getih Leaves (EESGL). METHODS: EESGL was tested for antioxidant activity in vitro and in vivo. Antihyperlipidemia test of SGL is done by looking at blood lipid parameters, that are total cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). 2,2-diphenyl-1-picrylhydrazyl (DPPH) of SGL and atorvastatin showed that Inhibition Concentra

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Miao, Hua, Ming-Hua Li, Xu Zhang, Sheng-Jun Yuan, Charlene C. Ho, and Ying-Yong Zhao. "The antihyperlipidemic effect of Fu-Ling-Pi is associated with abnormal fatty acid metabolism as assessed by UPLC-HDMS-based lipidomics." RSC Advances 5, no. 79 (2015): 64208–19. http://dx.doi.org/10.1039/c5ra09766e.

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Hidayati, Evi Nurul, Annisa Maulidia Rahayyu, and Eni Masruriati. "Nanoparticle formulation of ethanolic extract of Syzygium polyanthum leaf using chitosan and cross-linking method." Pharmaciana 15, no. 1 (2025): 132–42. https://doi.org/10.12928/pharmaciana.v15i1.25834.

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Syzygium polyanthum (bay leaves) is widely used in Indonesia and has been shown to have pharmacological activity, such as antihyperlipidemia. The nanoparticle is a delivery system that enhances therapy effectiveness, minimizes side effects, and ensures safety. Therefore, this study aimed to improve the antihyperlipidemic efficacy of Syzygium polyanthum extract by formulating it into nanoparticles. The polymer that is used in this nanoparticle formulation is chitosan, while the cross-linking agent that is used is sodium tripolyphosphate. Three formulations have been developed, each with differe

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Debnath, Bikash, Kuntal Manna, Waikhom Somraj Singh, and Sanchari Goswami. "Formulation and evaluation of new herbal nutraceutical tablet for the treatment of diabetes mellitus." Journal of Drug Research in Ayurvedic Sciences 9, no. 1 (2024): 29–39. http://dx.doi.org/10.4103/jdras.jdras_48_23.

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Abstract BACKGROUND: Herbal nutraceutical dosage forms a dietary supplement that improves various chronic diseases. This study aimed to formulate and evaluate new herbal nutraceutical tablets and assess antihyperglycemic and antihyperlipidemia effects in ob/ob mice. METHODS: A herbal nutraceutical tablet was prepared by the wet granulation method. Proximate composition was determined by the Association of Official Analytical Chemists methods. The high-performance liquid chromatography method was used for the estimation of water-soluble vitamins and fat-soluble vitamins. An atomic absorption sp

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Syam, Nindrahayu, Andi Ariyandy, Ika Yustisia, Sulfahri, and Yusfina. "IIn Silico Testing On The Activity Of Flavonol In Sterculia foetida Leaf As Natural Anti Hyperlipidemia Compounds." International Journal of Applied Biology 6, no. 1 (2022): 144–48. http://dx.doi.org/10.20956/ijab.v6i1.19918.

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This study aims to measure the biological activity of flavonols in the leaves of Sterculia foetida as an antihyperlipidemic drug. The chemical structure of flavonols contained in the leaves of Sterculia foetida was taken from the literature. The target protein used was 3-hydroxy 3-methylglutaryl coenzyme A reductase and the control was simvastatin. Water molecules have been removed with PyMol v2.5.2 Software. Docking between the target protein and flavonols was performed using PyRx-Python Prescription 0.8 Software. The results showed that flavonol compounds have greater potential for antihyper

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CARELESS, D., and M. COHEN. "Rheumatic manifestations of hyperlipidemia and antihyperlipidemia drug therapy." Seminars in Arthritis and Rheumatism 23, no. 2 (1993): 90–98. http://dx.doi.org/10.1016/s0049-0172(05)80015-0.

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Amal, Andi Nurzakiah, Dewi Darwati Agustini, and Surya Amal. "STUDI INTERAKSI OBAT ANTIHIPERLIPIDEMIA PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT SWASTA CIKAMPEK." Jurnal Buana Farma 4, no. 4 (2024): 558–63. https://doi.org/10.36805/jbf.v4i4.1209.

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Hyperlipidemia is a lipid metabolism disorder characterized by an increase in total cholesterol levels in the blood, which is a risk factor for various cardiovascular diseases. Treatment of hyperlipidemia is often combined with other drugs, increasing the potential for drug interactions. This study aims to identify the severity of antihyperlipidemia drug interactions in outpatients in private hospitals in Cikampek during the period of June to December 2023. The research uses an analytical survey design with a retrospective approach. Data were obtained from 251 patient prescriptions that met th

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Lee, Seung-Joo, Mi-Jin Yim, Gwang-Woo Kim, Soon-Yeong Cho, and Jong-Won Choi. "Antihyperlipidemia and Antiarteriosclerosis of Hizikia fusiformis in Sprague-Dawley Rats." Korean Journal of Fisheries and Aquatic Sciences 44, no. 5 (2011): 443–50. http://dx.doi.org/10.5657/kfas.2011.0443.

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Tung, Yu-Tang, Chieh-Hsi Wu, Wen-Chao Chen, et al. "Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats." Nutrients 14, no. 21 (2022): 4665. http://dx.doi.org/10.3390/nu14214665.

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Ascophyllum nodosum and Fucus vesiculosus both contain unique polyphenols called phlorotannins. Phlorotannins reportedly possess various pharmacological activities. A previous study reported that the activity of phlorotannin is strongly correlated with the normalization of metabolic function, and phlorotannins are extremely promising nutrients for use in the treatment of metabolic syndrome. To date, no study has explored the antihyperlipidemic effects of phlorotannins from A. nodosum and F. vesiculosus in animal models. Therefore, in the present study, we investigated the effects of phlorotann

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12

SEKIMOTO, HIROSHI. "Antihyperlipidemia and metabolism of intestinal sterol. With emphasis on cholesterol epoxide." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 19, no. 1 (1988): 89–90. http://dx.doi.org/10.3999/jscpt.19.89.

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13

Xu, Ping, Le Ying, Jing Wu, Dedong Kong, and Yuefei Wang. "Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea." Food & Function 7, no. 6 (2016): 2667–74. http://dx.doi.org/10.1039/c5fo01389e.

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In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats.

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14

Ejiroghene, Ahante, G. Moke Emuesiri, K. Anachuna Kenneth, M. Osifo Itohan, S. Nworu Chukwuemeka, and A. Akah Peter. "An Investigation of the Antihyperlipidemic and Antioxidant Activities of the Crude Extract and Fractions of Phaseolus vulgaris Linn on Experimental Rats." Pharmaceutical and Chemical Journal 4, no. 4 (2017): 66–78. https://doi.org/10.5281/zenodo.13785030.

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This research aimed at investigating the antihyperlipidemic and antioxidants activities of the crude extract and fractions of <em>Phaseolus vulgaris Linn</em>. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended in aqueous medium and solvents of increasing polarity to obtained the n-hexane fraction (PVHF), ethylacetate fraction (PVEF), and butanol fraction (PVBF) in that order. Acute, sub-acute a

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Dalwadi, Pankti P., Jigisha L. Patel, and Pragnesh V. Patani. "Tephrosia purpurea Linn (Sharpunkha, Wild Indigo): A Review on Phytochemistry and Pharmacological Studies." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 108–21. http://dx.doi.org/10.30750/ijpbr.2.1.18.

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Tephrosia purpurea (fabaceae) commonly known in sanskrit as ‘sharapunkha’ is highly branched ,herbaceous, suberect, perennial herb.widely grown in india. Whole plant and various parts of the plant are useful as ayurvedic medicines. Medicinal uses of drugs are tonic, laxative, diuretic, bronchitis, bilious febrile attack, boils, pimples, diarrhea, gonorrhea, rheumatism and cures disease of heart, spleen and blood. The pharmacological studies have shown that Tephrosia purpurea posses following biological activity such as antiulcer, antimicrobial, antibacterial, anti viral, anti asthmatic ,hepato

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Hilma, Novia, Nuri Nuri, Endah Puspitasari, and Indah Yulia Ningsih. "Gambaran Histopatologi Organ Jantung Tikus Putih Jantan Galur Wistar (Rattus norvegicus) dalam Uji Toksisitas Akut Kombinasi Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lmk.) dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.)." Pustaka Kesehatan 6, no. 2 (2018): 240. http://dx.doi.org/10.19184/pk.v6i2.7574.

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 Jati belanda leaves (Guazuma ulmifolia Lmk.) and Roselle petals (Hibiscus sabdariffa L.) have been known for their activity as antihyperlipidemia with different mechanisms. Combination of these plants was expected to has a synergy effect in reducing cholesterol. However, the toxicity of jati belanda leaves and roselle petals extract combination must be investigated for knowing its safety. Based on the acute toxicity test, the LD50 value of jati belanda leaves and roselle petals extract combination was >5,000 mg/kg bw. It was classified as category 5 or unclassified. This research aim

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Ruslin, Ruslin, Henny Kasmawati, Suriani Suriani, Sundar Ihsan, and Desi Sartina. "Activity Assay of Etanol Ectract of Lansau As Antihyperlipidemic." Indonesian Journal of Pharmaceutical Science and Technology 6, no. 3 (2019): 118. http://dx.doi.org/10.24198/ijpst.v6i3.21611.

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Hyperlipidemia is a condition due to increased levels of total cholesterol such as triglycerides, Low Density Lipoprotein (LDL) and decreased levels of High Density Lipoprotein (HDL). Hyperlipidemia can trigger wall thickening and narrowing of arteries, this condition can cause abnormality of fat metabolism in the blood and creates chronic disease. Lansau herb of the Muna tribe of Southeast Sulawesi consists of 44 ingredients of medicinal plants empirically used to treat various diseases such as koleseterol. The aim of this study was to determine the effect of ethanolic extract to the hispatol

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Widyawati, Tri, Siti Syarifah, Milahayati Daulay, and Fitri Mustanti Lolyta. "The Potency of Artocarpus Heterophyllus Leaf as a Facial Skin Care Ingredient in Clay Mask Formulation." Asian Journal of Pharmaceutical Research and Development 7, no. 6 (2019): 51–54. http://dx.doi.org/10.22270/ajprd.v7i6.631.

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Artocarpus heterophyllus (Ah), common name as nangka, has been reported to have antidiabetic, antihyperlipidemia, antimicrobial and antioxidant activity. Balinese women used its leaves for facial treatment. This study aims to evaluate its leaf potency for facial skin care. Ethanol extract of Ah (EEAh) that obtained by maceration was prepared into 3 clay mask formulations (FI: 1%, FII:3% and FIII:5%). F0 was used as control group. A total of 12 volunteers were treated with clay mask to evaluate its effect on moisture and pores size after intervention. The data were analysed using Kruskall Walli

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Wang, Chao-Yong, Li Tang, Jian-Wu He, Jing Li, and Yuan-Zhong Wang. "Ethnobotany, Phytochemistry and Pharmacological Properties of Eucommia ulmoides: A Review." American Journal of Chinese Medicine 47, no. 02 (2019): 259–300. http://dx.doi.org/10.1142/s0192415x19500137.

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Eucommia ulmoides Oliver, a single species of Eucommia genus belonging to the Eucommiaceae family, is an endemic in China and has been used in traditional Chinese medicine for nearly two thousand years. Records from different historical periods highlight E. ulmoides and its officinal botanical parts, usefulness in adaptation to disease and its central role in Chinese medicine theory. There are also historical collection documents for minorities in China. Tearing the leaves, bark and fruit produces strands of latex; a description of E. ulmoides’s morphological features is recorded in this paper

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Kan, Wei-Chih, Shu-Chun Kuo, Tsair-Wei Chien, et al. "Therapeutic Duplication in Taiwan Hospitals for Patients With High Blood Pressure, Sugar, and Lipids: Evaluation With a Mobile Health Mapping Tool." JMIR Medical Informatics 8, no. 7 (2020): e11627. http://dx.doi.org/10.2196/11627.

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Background Cardiovascular disease causes approximately half of all deaths in patients with type 2 diabetes. Duplicative prescriptions of medication in patients with high blood pressure (hypertension), high blood sugar (hyperglycemia), and high blood lipids (hyperlipidemia) have attracted substantial attention regarding the abuse of health care resources and to implement preventive measures for such abuse. Duplicative prescriptions may occur by patients receiving redundant medications for the same condition from two or more sources such as doctors, hospitals, and multiple providers, or as a res

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Ma, Hang, Yinran Hu, Zongyao Zou, Min Feng, Xiaoli Ye, and Xuegang Li. "Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice." Drug Development Research 77, no. 4 (2016): 163–70. http://dx.doi.org/10.1002/ddr.21302.

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Susanti, Hari, Subagus Wahyuono, Ratna Asmah Susidarti, and Ika Puspita Sari. "PENETAPAN KADAR DIOSGENIN DALAM EKSTRAK AIR Costus speciosus SECARA HPLC." Majalah Obat Tradisional 22, no. 1 (2017): 1. http://dx.doi.org/10.22146/tradmedj.24171.

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Costus speciosus has been reported to have biological activity among antidiabetic, antihyperlipidemia, antioxidants. One of the chemical constituents that is responsible for some of the biological activity is diosgenin. This study aimed to determine diosgenin content of Costus speciosus water extract (CS). Water extract of CS was obtained with infundation method. The extract was dried using freeze dryer. The assay of diosgenin was performed by HPLC method. HPLC system used: LiChrospher® 100 RP-18 endcapped (5 µm) column length 25cm, colimn id 4 mm as stationary phase, acetonitrile-water (9: 1

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Cheng, Daye, Bin Liang, and Yunhui Li. "Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/162724.

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TheGinkgo bilobaextract (GBE) has been reported to have a wide range of health benefits in traditional Chinese medicine. The aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in maleWistarrats by the administration of STZ (60 mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300 mg/kg b.w.) was administered orally once a day for a period of 30 days. Body weight and blood glucose levels were determined in different experimental days. Serum lipid profile and antioxidant enzymes in hepatic and pancreatic

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Khumpirapang, Nattakanwadee, Supreeya Srituptim, and Worawut Kriangkrai. "Optimization for Powder Yield of Spray-Dried Garlic Extract Powder Using Box-Behnken Experimental Design." Key Engineering Materials 859 (August 2020): 301–6. http://dx.doi.org/10.4028/www.scientific.net/kem.859.301.

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Garlic exerts its pharmacological activities; antihyperglycemic, antihyperlipidemia, antihypercholesterolemic, and antihypertensive activity. Therefore, the aim of this study was to determine and optimize the influence of the individual and interactive effect of process conditions variables on the yield of garlic extract powders by three factors and three level-Box-Behnken design under response surface methodology. Spray drying processes the transformation of a garlic juice extract into a dried powder, where usually maltodextrin (MD) as a drying agent is used. According to experimental design,

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Toni.S, Rifqi Maulana, Marhani Apriana, Muhammad Choerul Huda, et al. "ARTIKEL REVIEW: STUDI FITOKIMIA DAN FARMAKOLOGI PARIJOTO (Medinilla magnifica)." Jurnal Buana Farma 2, no. 3 (2022): 36–46. http://dx.doi.org/10.36805/jbf.v2i3.548.

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Health problems are one of the most complex problems, the sanitation process in improving health with various uses of plants in the State of Indonesia. A country that will be rich in natural resources. As a form of serious treatment that improves health from various diseases in Indonesia, called by utilizing Parijoto fruit (Medinilla magnifica) by utilizing the active substances contained in the fruit in the form of flavonoids, tannins, saponins and alkaloids through in vitro and in vitro tests. In vitro which has important properties in the treatment process in Parijoto fruit, extract is made

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Rustamsyah, Ardi, Siti Nuraeni, Faizah Min Fadhlillah, Mimin Kusmiyati, and Dani Sujana. "REVIEW: STUDI ETNOBOTANI FARMAKOLOGI DAN FITOKIMIA PANDANUS TECTORIUS DI INDONESIA." Jurnal Insan Farmasi Indonesia 5, no. 2 (2022): 192–202. http://dx.doi.org/10.36387/jifi.v5i2.1080.

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The purpose of the review of Pandanus tectorius (P. tectorius) is to provide information on the ethnobotany, pharmacological and phytochemical activities of sea pandanus (P. tectorius) included in the pandanaceae tribe, Pandanus odoratissimus is a synonym of P. tectorius. Pandanus fasicularis Lam is also a synonym of P. tectorius, P. odoratissimus. Sea pandanus (P. tectorius) is a shrub plant that is still not widely utilized. P. tectorius is also one type of plant from the pandan family that grows wildly on the coast. Sea pandanus is widely found in South Asia, tropical Australia. This plant

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Pratiwi, Ulfa, Muharni Muharni, Ferlinahayati Ferlinahayati, Heni Yohandini, and Suheryanto Suheryanto. "Antihyperlipidemia activity of sungkai (Peronema canescens) leaves extract in albino rats Rattus noverticus (Wistar strain) with propylthiouracil-induced hyperlipidemia." Medicinal Plants - International Journal of Phytomedicines and Related Industries 14, no. 4 (2022): 589–96. http://dx.doi.org/10.5958/0975-6892.2022.00064.8.

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Sansri, Veerawat, Morakot Sroyraya, Pochamana Phisalprapa, et al. "Suppressive Effect of Coffee Leaves on Lipid Digestion and Absorption In Vitro." Foods 13, no. 15 (2024): 2445. http://dx.doi.org/10.3390/foods13152445.

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Background: Coffee leaves are a major source of bioactive components and are used as ethnomedicine. However, despite their traditional medicinal use, information about their effects on antihyperlipidemia remains limited. Methods: The aims of this study were to evaluate the main components of leaf extracts from Arabica and Robusta coffees and to examine the potential of these coffee leaves in reducing lipid digestion and absorption in vitro. Results: Coffee leaf extracts from Arabica coffee contain a high amount of caffeine, whereas extracts from Robusta coffee contain high amounts of chlorogen

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Ontawong, Atcharaporn, Naruwan Saowakon, Pornpun Vivithanaporn, et al. "Antioxidant and Renoprotective Effects ofSpirogyra neglecta(Hassall) Kützing Extract in Experimental Type 2 Diabetic Rats." BioMed Research International 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/820786.

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Spirogyra neglectaextract (SNE) has shown antihyperglycemia and antihyperlipidemia in type 2 diabetic mellitus (T2DM) rats. This study investigated the antioxidant and renoprotective effects of SNE in T2DM rats induced by high-fat diet with low-single dose streptozotocin. T2DM rats were fed daily with SNE (0.25, 0.5, and 1 g/kg BW) for 12 weeks. Renal morphology, malondialdehyde levels, qPCR, and western blotting were analyzed. Renal cortical slices were used to determine renal transport of organic anions, which are estrone sulfate andpara-aminohippurate, mediated through organic anion transpo

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Sharma, Bhaskar, Shiv Kumar, Sufiyan Siddiqui, Guru Ram, and Manisha Chaudhary. "Ameliorative effects of aqueous leaf extract of aloe arborescens on anti- hyperglycaemia and antihyperlipidemia alterations in alloxan-induced diabetic mice." Journal of Investigational Biochemistry 2, no. 2 (2013): 71. http://dx.doi.org/10.5455/jib.20130508065910.

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Muharni, Muharni, Julinar Julinar, Heni Yohandini, Fitrya Fitrya, and Rima Melati. "Antihyperlipidemia activity of ethanol extract the stem bark of Flacourtia rukam on propylthiouracil-induced albino rats, Rattus noverticus (Wistar strain)." IOP Conference Series: Materials Science and Engineering 1011 (January 6, 2021): 012042. http://dx.doi.org/10.1088/1757-899x/1011/1/012042.

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Chen, Tong, Gong Cheng, Siming Jiao, et al. "Expression and Biochemical Characterization of a Novel Marine Chitosanase from Streptomyces niveus Suitable for Preparation of Chitobiose." Marine Drugs 19, no. 6 (2021): 300. http://dx.doi.org/10.3390/md19060300.

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It is known that bioactivities of chitooligosaccharide (COS) are closely related to the degree of polymerization (DP); therefore, it is essential to prepare COS with controllable DP, such as chitobiose showing high antioxidant and antihyperlipidemia activities. In this study, BLAST, sequence alignment and phylogenetic analysis of characterized glycoside hydrolase (GH) 46 endo-chitosanases revealed that a chitosanase Sn1-CSN from Streptomyces niveus was different from others. Sn1-CSN was overexpressed in E. coli, purified and characterized in detail. It showed the highest activity at pH 6.0 and

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Isdadiyanto, Sri, Siti Muflichatun Mardiati, and Agung Janika Sitasiwi. "Blood-Glucose Levels of Rats Given High-Fat Diets after Administration of Neem Leaf Ethanolic Extract." Biosaintifika: Journal of Biology & Biology Education 13, no. 2 (2021): 142–48. http://dx.doi.org/10.15294/biosaintifika.v13i2.29516.

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Azadirachta indica A. Juss (Neem) is a medicinal plant that contains antioxidants, antihyperlipidemia, and has antidiabetic activity. This research aimed to examine the effect of neem leaf ethanolic extract on blood glucose levels of white rats given high-fat rations. The male white rats (Rattus norvegicus L.) with two months of age were used. The treatment of test animals consisted of six treatment groups and four replications, namely: the control group (P0); given high fat rations + duck egg yolk 2.5 ml/200gBW (P1); given high-fat rations + 8 mg/200gBW simvastatin (P2); and P1+ the dose of n

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Zhang, Jian-Xiu, Wei-Jun Feng, Guan-Cheng Liu та ін. "Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-κB/MAPK Signaling Pathways". American Journal of Chinese Medicine 48, № 03 (2020): 579–95. http://dx.doi.org/10.1142/s0192415x20500299.

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Corosolic acid (CA) is the main active component of Lagetstroemia speciosa and has been known to serve as several different pharmacological effects, such as antidiabetic, anti-oxidant, and anticancer effects. In this study, effects of CA on the hepatic lipid accumulation were examined using HepG2 cells and tyloxapol (TY)-induced hyperlipidemia ICR mice. CA significantly inhibited hepatic lipid accumulation via inhibition of SREBPs, and its target genes FAS, SCD1, and HMGCR transcription in HepG2 cells. These effects were mediated through activation of AMPK, and these effects were all abolished

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Nurul Patihirrahmi, Muhammad Yul Fikry, Dwi Agustini, Andri Azmul Fauzi, Saiful Bahri, and Lalu Muktar. "Pemberdayaan Masyarakat Melalui Pembuatan Jamu Hebal Di Desa Kuripan Timur Kabupaten Lombok Barat." Al Hayat: Jurnal Pengabdian Masyarakat 3, no. 1 (2025): 41–49. https://doi.org/10.62588/ahjpm.2025.v3i1.0134.

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Jamu is local wisdom that has developed in society, where people still believe that the benefits of this traditional drink can cure various diseases without causing side effects. This research aims to find out how to make kencur rice herbal medicine and tamarind turmeric herbal medicine and their benefits. This research uses the method of socialization and education to the community about the use of traditional herbal medicine (rice kencur and turmeric tamarind) and how to make it. Kencur rice herbal medicine is a nutritious herbal drink formulated from several ingredients. The main sources of

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Setyani, Wahyuning, Hanny Setyowati, Dwi Hadi Setya Palupi, Hanievia Rahayunnissa, and Maywan Hariono. "Antihyperlipidemia and Antihyperglycemic Studies of Arcangelisiaflava(L.)Merr. Phenolic Compound: Incorporation of In Vivo and In Silico Study at Molecular Level." Indonesian Journal of Pharmaceutical Science and Technology 6, no. 2 (2019): 84. http://dx.doi.org/10.24198/ijpst.v6i2.20211.

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Breijyeh, Zeinab, and Rafik Karaman. "Enzyme Models—From Catalysis to Prodrugs." Molecules 26, no. 11 (2021): 3248. http://dx.doi.org/10.3390/molecules26113248.

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Enzymes are highly specific biological catalysts that accelerate the rate of chemical reactions within the cell. Our knowledge of how enzymes work remains incomplete. Computational methodologies such as molecular mechanics (MM) and quantum mechanical (QM) methods play an important role in elucidating the detailed mechanisms of enzymatic reactions where experimental research measurements are not possible. Theories invoked by a variety of scientists indicate that enzymes work as structural scaffolds that serve to bring together and orient the reactants so that the reaction can proceed with minim

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Saputra, I. Putu Bayu Agus, and I. Putu Dedy Arjita. "The Potential of Flavonoid Derivative Compounds as Inhibitors of the HMG-CoA Reductase Enzyme for Candidate of Hypercholesterolemia Drugs." Jurnal Penelitian Pendidikan IPA 10, no. 5 (2024): 2286–93. http://dx.doi.org/10.29303/jppipa.v10i5.6237.

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Cardiovascular disease (CVD) is a disease that causes death in the world. Behavioral risk factors are crucial in dealing with CVD disease. High levels of cholesterol in the blood are associated with hypercholesterolemia. It can increase the risk of CVD disease. The HMG-CoA reductase enzyme is an enzyme that plays a role in cholesterol synthesis. It will convert the HMG-CoA compound into the mevalonate. Inhibition of this enzyme can reduce cholesterol synthesis because it inhibits the formation of mevalonate, which is the initial stage of cholesterol synthesis. Herbal compounds are compounds pr

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Sasnita, Merida, Anny Sartika Daulay, Ridwanto Ridwanto, and Haris Munandar Nasution. "Effect of Extraction Method on Yellow Wood Rendement and Phenolic Content (Arcangelisia flava (L.) Merr) UV-Vis Spectrophotometry Extract of Ethanol." Indonesian Journal of Science and Pharmacy 1, no. 1 (2023): 31–35. https://doi.org/10.63763/ijsp.v1i1.25.

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Indonesia is a country rich in biodiversity. With the wealth of natural resources, there is very much that can be used from flora and fauna to treat various diseases, yellow wood is one of the plants that have medicinal properties and has not been widely studied, yellow wood is efficacious as antimicrobial, antioxidant, antihyperlipidemia, and anticancer. The objective of this study was to determine the class of chemical compounds found in simplicial and extracts of yellow wood plants and to determine the effect of extraction methods on the yield and phenolic levels of ethanol extracts of yell

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Jin, Hui, Yuan-Ri Guo, Min Sang Kim, et al. "Effect of ACG-1, an Extract Blend of Angelica gigas, Cynanchum wilfordii, and Ginkgo biloba, on Blood Circulation Improvement Via Antiplatelet Aggregation and Antihyperlipidemia." Journal of Medicinal Food 24, no. 2 (2021): 135–44. http://dx.doi.org/10.1089/jmf.2020.4852.

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Yuan, Chunyu, Myeongcheol Shin, Youngjae Park та ін. "Linalool Alleviates Aβ42-Induced Neurodegeneration via Suppressing ROS Production and Inflammation in Fly and Rat Models of Alzheimer’s Disease". Oxidative Medicine and Cellular Longevity 2021 (10 березня 2021): 1–10. http://dx.doi.org/10.1155/2021/8887716.

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Terpenes are vital metabolites found in various plants and animals and known to be beneficial in the treatment of various diseases. Previously, our group identified terpenes that increased the survival of Alzheimer’s disease (AD) model flies expressing human amyloid β (Aβ) and identified linalool as a neuroprotective terpene against Aβ toxicity. Linalool is a monoterpene that is commonly present as a constituent in essential oils from aromatic plants and is known to have anti-inflammatory, anticancer, antihyperlipidemia, antibacterial, and neuroprotective properties. Although several studies h

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Wang, Tien-Ju, Angela Shin-Yu Lien, Jiun-Liang Chen, Cheng-Hui Lin, Yin-Shuo Yang, and Sien-Hung Yang. "A Randomized Clinical Efficacy Trial of Red Yeast Rice (Monascus pilosus) Against Hyperlipidemia." American Journal of Chinese Medicine 47, no. 02 (2019): 323–35. http://dx.doi.org/10.1142/s0192415x19500150.

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Red yeast rice (RYR) has been used as an alternative treatment for hyperlipidemia. According to the previous studies, other compounds, besides monacolin K in RYR, may also reduce the serum lipid level. This study aims at examining the efficacy of monacolin K-rich and Gamma-Aminobutyric Acid (GABA)-rich RYR (Monascus pilosus) with regards to treating hyperlipidemia in a randomized control, double-blind clinical trial. In the research, we assigned 50 eligible subjects to monacolin K-rich RYR, GABA-rich RYR and placebo groups ([Formula: see text], 17, 17, respectively). The concentrations of TC,

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Jabeen, Aisha, Mirza Tasawer Baig, Shumaila Shaikh, et al. "Review on Pharmacological Effects of Grape Seed Oil." RADS Journal of Biological Research & Applied Sciences 12, no. 2 (2021): 154–59. https://doi.org/10.37962/jbas.v12i2.274.

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Background: Vitis vinifera has been long used as herbal medicine, dietary supplement, and functional food due to its hydrophilic and lipophilic constituents. Vitis vinifera is commonly known as the grape vine, and many species of Vitris vinifera have been profusely found in the region of Mediterranean, Europe and many areas of Asia including Morocco, and Portugal. Objectives: The objective of this review was to summarize the pharmacological activities of Grape Seed Oil (GSO) by analyzing various effects including anti-inflammatory, neuroprotective, anti-hyperlipidemic, anti-hepatotoxic, wound-

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Anggraeni, Wenty, Chrismis Novalinda Ginting, Linda Chiuman, Sahna Ferdinand Ginting, and Fiska Maya Wardhani. "Antioxidant and Anti-inflammatory Activities of Extract Ethanol Curcuma zedoaria." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 1126–31. http://dx.doi.org/10.3889/oamjms.2022.7511.

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BACKGROUND: Inflammation is a response of the body to injury or infection. When an injury occurs, the body will try to neutralize and eliminate harmful agents from the body and prepare for tissue repair. White turmeric is known to have secondary metabolites that have pharmacological activities such as antioxidants, antihyperlipidemia, antidiabetic and others. AIM: This study aims to determine the anti-inflammatory, antioxidant, total phenol and flavonoid activity of white turmeric ethanol extract. MATERIALS AND METHODS: This study used carrageenan as an inflammatory inducer. This s

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Oktaviana, Nurul, Nadia Isnaini, Essy Harnelly, Zulkarnain Zulkarnain, Syaifullah Muhammad, and Misrahanum Misrahanum. "Theoretical Evaluation of Michelia Species’ Bioactive Compounds and Theraupetic Potential: A Literature Review." Grimsa Journal of Science Engineering and Technology 1, no. 2 (2023): 52–59. http://dx.doi.org/10.61975/gjset.v1i2.12.

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Michelia alba is a multifunctional plant found in Indonesia and is also called magnolia. Michelia alba is a tree known for its essential oil, which has long been used as a fragrance ingredient in perfumes and cosmetics. The potential of M. alba is immense for use in the prevention and treatment of disease as well as the management of human health and wellness. To date, there have been few publications regarding the biological activities of M. alba, focusing on tyrosinase inhibitory, antibacterial, antidiabetic, anti-inflammatory and antioxidant activities. However, M. alba may have additional

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Winthoko, Eka Nora Vitaloka Aprilia Putri, Anna Roosdiana, Dyah Ayu Oktaviani A. Pratama, et al. "The potency of green grass jelly extract (Premna oblongifolia Merr) as antihyperlipidemia towards aorta histopathology representation of rat (Rattus norvegicus) induced with high fatty diet (HFD)." Jurnal Teknologi Laboratorium 9, no. 1 (2020): 97–102. http://dx.doi.org/10.29238/teknolabjournal.v9i1.174.

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Green grass jelly (Premna oblongifolia merr) is a plant containing fiber and chlorophyll which can lower cholesterol and triglyceride levels. This study have aims to investigate the potency of green grass jelly extract (Premna oblongifolia Merr) to prevent hyperlipidemia. The animal mode used for this study is male Rattus norvegicus, Wistar strain, the age of 8 weeks, and weight of 200 g which is divided into 5 groups of treatment namely group Kn (negative control), Kp (positive control), Kp1, Kp2, and Kp3 induced with HFD and green grass jelly extract at a dose of 5.27 g/ kg BW/ daily, 8.43 g

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Sari, Dina, Nurhadi Ibrahim, Nina Herlina, et al. "The Effects of Red Palm Oil, Koja Bay Leaves, and Passion Fruit Seeds Formulation on Antioxidant Activity, Antihyperlipidemia, BDNF, and Lipase Enzyme Activity on Sprague-Dawley Rats." Journal of Experimental Pharmacology Volume 16 (September 2024): 271–84. http://dx.doi.org/10.2147/jep.s466494.

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Adawiyah, Rabiatul, Fera Sartika, and Fahruddin Arfianto. "Potensi Ekstrak Akar Kalakai (Stenochlaena palutris Bedd) Sebagai Antihiperlipidemia Yang Diuji Secara In Vivo." Jurnal Pharmascience 7, no. 1 (2020): 62. http://dx.doi.org/10.20527/jps.v7i1.8075.

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ABSTRAK Tumbuhan kalakai atau sering disebut paku haruan atau pakis merupakan tumbuhan khas Kalimanatan yang banyak digunakan sebagai tumbuhan obat. Kalakai mengandung beberapa senyawa bioaktif seperti fenolik, flavonoid, alkaloid dan keluarga terpenoid yang efektif sebagai antioksidan. Tujuan penelitian ini untuk menentukan aktivitas antihiperlipidemia dar i ekstrak akar kalakai yang diuji secara in vivo pada tikus wistar. Metode yang digunakan adalah melakukan uji aktivitas antihiperlipidemia dengan cara memberi perlakuan hewan coba dan melakukan pengukuran kadar trigliserida dan kolesterol

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Yuan, Guozhen, Shuai Shi, Qiulei Jia, et al. "Use of Network Pharmacology to Explore the Mechanism of Gegen (Puerariae lobatae Radix) in the Treatment of Type 2 Diabetes Mellitus Associated with Hyperlipidemia." Evidence-Based Complementary and Alternative Medicine 2021 (April 16, 2021): 1–14. http://dx.doi.org/10.1155/2021/6633402.

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Rapid increases in metabolic disorders, such as type 2 diabetes mellitus (T2DM) and hyperlipidemia, are becoming a substantial challenge to worldwide public health. Traditional Chinese medicine has a long history and abundant experience in the treatment of diabetes and hyperlipidemia, and Puerariae lobatae Radix (known as Gegen in Chinese) is one of the most prevalent Chinese herbs applied to treat these diseases. The underlying mechanism by which Gegen simultaneously treats diabetes and hyperlipidemia, however, has not been clearly elucidated to date. Therefore, we systematically explored the

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BRIGGS, GERALD G. "Antihyperlipidemic Agents." Ob.Gyn. News 40, no. 14 (2005): 10. http://dx.doi.org/10.1016/s0029-7437(05)70676-5.

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