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Artykuły w czasopismach na temat „Antihypertensive combination therapy”

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Data publikacji: 2 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Ostroumova, O. D., V. V. Vikentiev, and T. F. Guseva. "COMBINATION ANTIHYPERTENSION THERAPY: TRIPLE FIXED COMBINATION OF ANTIHYPERTENSIVE DRUGS." Russian Journal of Cardiology, no. 2 (January 1, 2017): 92–99. http://dx.doi.org/10.15829/1560-4071-2017-2-92-99.

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Weir, M. R. "Antihypertensive combination therapy." Drugs of Today 34, no. 1 (1998): 5. http://dx.doi.org/10.1358/dot.1998.34.1.485192.

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Kireyev, I. V., and N. V. Zhabotynska. "The study of the effect of adherence with modern recommendations on antihypertensive therapy on compliance of patients with arterial hypertension." Social Pharmacy in Health Care 8, no. 1 (2022): 27–33. http://dx.doi.org/10.24959/sphhcj.22.248.

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Aim. To study the relationship between the adherence with modern recommendations on antihypertensive therapy using fixed combinations of drugs in a “single” tablet with patients’ compliance and suggest ways to improve compliance in patients with hypertension based on the data obtained. 
 Materials and methods. Compliance of patients was assessed using the compliance scale of Hill-Bone arterial hypertension therapy; the nature of the antihypertensive therapy received was analyzed.
 Results. Compliance of hypertensive patients was 63.64 %. No patients with low compliance and no complia
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4

Nickey, William A. "Combination antihypertensive therapy: Rational selection." Journal of the American Osteopathic Association 90, no. 12 (1990): 1085–91. http://dx.doi.org/10.1515/jom-1990-901213.

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Konradi, A. O. "Combination antihypertensive therapy - newer indications." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 15, no. 1 (2009): 46–49. http://dx.doi.org/10.18705/1607-419x-2009-15-1-46-49.

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MESSERLI, F. "Antihypertensive efficacy of combination therapy." American Journal of Hypertension 10, no. 4 (1997): 240A. http://dx.doi.org/10.1016/s0895-7061(97)89531-3.

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Khanom, Mehrunnissa, Md Amir Hossain, ASM Zahed, and Joyabrata Das. "Pattern of Antihypertensive Drugs Used For Hospitalised Adult Patients." Journal of Chittagong Medical College Teachers' Association 27, no. 2 (2017): 39–43. http://dx.doi.org/10.3329/jcmcta.v27i2.62363.

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Hypertension is a leading contributor to global burden of cardiovascular as well as cerebrovascular mortality and morbidity. This paper presents a study on prescription patterns of antihypertensive drugs at medicine ward of a private hospital. An observational study was done for 6 months period (1st March 2015 to 30th August 2015) on 82 Patients at Medicine ward of Southern Medical College Hospital. The objectives of this study were to identify whether monotherapy or combination therapy was most effective in controlling blood pressure, to identify types of antihypertensive drugs most commonly
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8

Ramadhani, Novely Dwita, Primanitha Ria Utami, Devi Ristian Octavia, and Ekanita Desiani. "Comparison of Blood Pressure in Hypertensive Patients with Monotherapy and Combination Antihypertensive Therapy." Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) 3 (November 13, 2023): 103. http://dx.doi.org/10.18860/planar.v3i0.2476.

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Background: Hypertension is a cardiovascular risk factor that is closely related to the patient's systolic and diastolic blood pressure profile. Objective: This study aims to determine the comparison of systolic and diastolic blood pressure profiles using antihypertensives in patients with cardiovascular risk factors. Method: Conducted in the period August-December 2021 on 83 patients who met the inclusion criteria, namely outpatients diagnosed with hypertension with cardiovascular risk factors, adult patients over 18 years of age, a medical record sheet, and a written prescription in full. Da
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9

Serdechnaya, E. V. "Efficacy and Organoprotection of Triple Combinations in the Treatment of Arterial Hypertension." Kardiologiia 63, no. 11 (2023): 80–86. http://dx.doi.org/10.18087/cardio.2023.11.n2582.

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The 2022 draft Russian guidelines on arterial hypertension recommend initiation of antihypertensive therapy with a combination of drugs in most patients with blood pressure above 150 / 90 mm Hg and / or in the presence of high-risk criteria. In 2021, the results of a 12-year analysis of the Brisighella Heart Study (BHS) were published. The aim of this study was to compare the use of different triple antihypertensive drug combinations in an Italian cohort of patients in real-life clinical practice. Combination antihypertensive therapy with a renin-angiotensin-aldosterone system inhibitor, amlod
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10

Morozova, T. E. "Combined antihypertensive therapy in the light of modern recommendations: strategy of one tablet." Systemic Hypertension 15, no. 4 (2018): 92–96. http://dx.doi.org/10.26442/2075082x.2018.4.180110.

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The review focuses on the main strategies of antihypertensive therapy set out in the 2018 ESC/ESH recommendations. The basis of antihypertensive therapy consists of five main classes of antihypertensive drugs, which should form the basis of the combined drug antihypertensive therapy in most patients. The single pill strategy is to take advantage of fixed combinations as a starting antihypertensive therapy for most patients. Among the fixed combinations, the combination of an ACE inhibitor with a diuretic (Noliprel®) remains one of the most preferred for antihypertensive therapy, since In addit
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11

Morozova, T. E., and S. V. Gontarenko. "Rational choice of combination antihypertensive therapy." Consilium Medicum 18, no. 1 (2016): 10–15. http://dx.doi.org/10.26442/2075-1753_2016.1.10-15.

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&NA;. "Combination antihypertensive therapy lowers stroke risk." Inpharma Weekly &NA;, no. 1308 (2001): 12. http://dx.doi.org/10.2165/00128413-200113080-00025.

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Hansson, Lennart, and Anders Himmelmann. "Calcium Antagonists in Antihypertensive Combination Therapy." Journal of Cardiovascular Pharmacology 18 (1991): S76—S80. http://dx.doi.org/10.1097/00005344-199106191-00014.

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Hansson, Lennart, and Anders Himmelmann. "Calcium Antagonists in Antihypertensive Combination Therapy." Journal of Cardiovascular Pharmacology 18 (1991): S76—S80. http://dx.doi.org/10.1097/00005344-199118101-00014.

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15

White, William B. "Antihypertensive class matters for combination therapy." Nature Reviews Cardiology 7, no. 6 (2010): 303–4. http://dx.doi.org/10.1038/nrcardio.2010.55.

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16

Markowitz, John S., Barbara G. Wells, and William H. Carson. "Interactions Between Antipsychotic and Antihypertensive Drugs." Annals of Pharmacotherapy 29, no. 6 (1995): 603–9. http://dx.doi.org/10.1177/106002809502900610.

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Objective: To provide a comprehensive review of the pharmacokinetic and pharmacodynamic interactions between antipsychotics and antihypertensives and to provide recommendations for the selection of antihypertensives in patients receiving antipsychotic therapy. Data Sources: A MEDLINE search of the English-language literature was used to identify pertinent human and animal studies, reviews, and case reports. Study Selection: All available sources were reviewed. Data Extraction: Background information was obtained from comprehensive reviews. Individual case reports were assimilated, and pertinen
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17

Mubarakshina, O. A., M. N. Somova, and G. A. Batishcheva. "Modern combination antihypertensive pharmacotherapy." Systemic Hypertension 15, no. 4 (2018): 30–33. http://dx.doi.org/10.26442/2075082x.2018.4.180149.

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Achievement of target blood pressure levels is one of the main issues in antihypertensive pharmacotherapy. The article presents updated 2018 European Guidelines recommendations on target blood pressure levels in antihypertensive therapy and combined antihypertensive pharmacotherapy advantages. Modern fixed combinations including those with three active agents are discussed. A review of studies that show effectiveness and safety of long acting dihydropyridine calcium channel blocker amlodipine, thiazid-like diuretic indapamide, and angiotensin-converting enzyme inhibitor perindopril arginine fi
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18

Karpenko, O. V. "Choosing the optimal antihypertensive therapy." Medicine of Ukraine, no. 8(254) (October 27, 2021): 15–18. http://dx.doi.org/10.37987/1997-9894.2021.8(254).245792.

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The article considers approaches to the selection of optimal antihypertensive therapy in order to achieve the target blood pressure in patients with hypertension in accordance with the latest Recommendations on hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology; ESC), as well as the circadian rhythm of blood pressure. Fixed combinations of renin-angiotensin-aldosterone system blockers, which include angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors, with calcium antagonists should be preferred. Taking such a fixed combi
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19

Kim, Sang Hyuck, Dong Wook Shin, Shinhye Kim, et al. "Prescribing Patterns of Antihypertensives for Treatment-Naïve Patients in South Korea: From Korean NHISS Claim Data." International Journal of Hypertension 2019 (August 25, 2019): 1–10. http://dx.doi.org/10.1155/2019/4735876.

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Background. Several factors influence the choice of antihypertensive drugs. To facilitate the rational use of drugs it is important to assess their prescription patterns over time. This study aims to evaluate doctors’ prescribing patterns of antihypertensive drugs for drug-naïve patients in South Korea. Methods. The claims data of the Korean National Health Insurance Research Database from 1 January 2011 to 31 December 2015 were analyzed. The data virtually cover the entire South Korean population. Antihypertensive drugs were further subdivided into angiotensin receptor blockers (ARBs), angiot
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20

Persu, Alexandre, Marilucy Lopez-Sublet, Engi Abd El-Hady Algharably, and Reinhold Kreutz. "Starting Antihypertensive Drug Treatment With Combination Therapy." Hypertension 77, no. 3 (2021): 800–805. http://dx.doi.org/10.1161/hypertensionaha.120.12857.

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Zhang, Zhen-Yu, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, and Jan A. Staessen. "Starting Antihypertensive Drug Treatment With Combination Therapy." Hypertension 77, no. 3 (2021): 788–98. http://dx.doi.org/10.1161/hypertensionaha.120.12858.

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22

Herrin, Melissa A., Laura Cecere Feemster, Kristina Crothers, Jane E. Uman, Chris L. Bryson, and David H. Au. "Combination Antihypertensive Therapy Among Patients With COPD." Chest 143, no. 5 (2013): 1312–20. http://dx.doi.org/10.1378/chest.12-1770.

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23

GILES, T. "Myths and realities of combination antihypertensive therapy." American Journal of Hypertension 18, no. 5 (2005): A267—A268. http://dx.doi.org/10.1016/j.amjhyper.2005.03.725.

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24

Dogas, Hana, Josipa Radic, Marijana Vuckovic, et al. "PRESCRIPTION OF SINGLE-PILL ANTIHYPERTENSIVE COMBINATION THERAPY." Journal of Hypertension 41, Suppl 3 (2023): e316. http://dx.doi.org/10.1097/01.hjh.0000942304.78069.41.

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25

Bellone, Marco, and Pierluigi Sbarra. "A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations." Farmeconomia. Health economics and therapeutic pathways 14, no. 4 (2013): 153–60. http://dx.doi.org/10.7175/fe.v14i4.886.

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BACKGROUND: Cardiovascular disease management and prevention represent the leading cost driver in Italian healthcare expenditure. In order to reach the target blood pressure, a large majority of patients require simultaneous administration of multiple antihypertensive agents.OBJECTIVE: To assess the economic impact of the use of fixed dose combinations of antihypertensive agents, compared to the extemporary combination of the same principles.METHODS: A cost minimization analysis was conducted to determine the pharmaceutical daily cost of five fixed dose combinations (olmesartan 20 mg + amlodip
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26

Sergeyeva, V. A. "Analysis of antihypertensive therapy and its adherence in hypertensive patients with and without concomitant diabetes mellitus." Systemic Hypertension 9, no. 4 (2012): 35–39. http://dx.doi.org/10.26442/sg28937.

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Among patients with hypertension and with a combination of hypertension and diabetes mellitus the majority does not reach target values of arterial pressure levels. There is a number of lacks in ambulatory antihypertensive therapy and adherence to it. The considerable number of patients continues to accept therapy irregularly, the choice of antihypertensive drugs and their combinations is not always adequate, non – medicamentous actions don’t realize by all patients. At the same time the powerful negative contribution is associated with low adherence of patients to spent antihypertensive thera
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27

An, Jaejin, Tiffany Luong, Lei Qian, et al. "Treatment Patterns and Blood Pressure Control With Initiation of Combination Versus Monotherapy Antihypertensive Regimens." Hypertension 77, no. 1 (2021): 103–13. http://dx.doi.org/10.1161/hypertensionaha.120.15462.

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Many patients with hypertension require 2 or more drug classes to achieve their blood pressure (BP) goal. We compared antihypertensive medication treatment patterns and BP control between patients who initiated combination therapy versus monotherapy. We identified adults with hypertension enrolled in a US integrated healthcare system who initiated antihypertensive medication between 2008 and 2014. Patient demographics, clinical characteristics, antihypertensive medication, and BP were extracted from electronic health records. Antihypertensive medication patterns and multivariable adjusted prev
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28

Sviryaev, Y. V., N. Zvartau, O. Rotar, L. Korostovtceva, A. Konradi, and A. Kalinkin. "CPAP-therapy in pharmacologically-treated hypertensive patients with sleep apnea." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 14, no. 3 (2008): 264–69. http://dx.doi.org/10.18705/1607-419x-2008-14-3-264-269.

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Correction of sleep disorders in hypertensive patients with obstructive sleep apnea (OSA) may improve response to treatment and facilitate achievement of target blood pressure (BP). Due to the absence of guidelines and insufficient number of studies in this patient population we decided to conduct a study in order to investigate efficacy of standard antihypertensive treatment in combination with CPAP therapy in hypertensive OSA patients. Population: The study enrolled 60 ambulatory or in-hospital hypertensive patients, which were assigned to 3 treatment groups: OSA patients on standard antihyp
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Malo, Sara, Isabel Aguilar-Palacio, Cristina Feja, María Jesús Lallana, Javier Armesto, and María José Rabanaque. "Effect of patient and treatment factors on persistence with antihypertensive treatment: A population-based study." PLOS ONE 16, no. 1 (2021): e0245610. http://dx.doi.org/10.1371/journal.pone.0245610.

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Purpose To analyze patterns of antihypertensive drug use among new users in a Southern European population, and identify patient- and treatment-related factors that influence persistence. Methods This is a retrospective observational study of new antihypertensive drug users aged ≥40 years in Aragón, Spain. Information on antihypertensive drugs (2014–2016) prescribed and dispensed at pharmacies via the public health system were collected from a regional electronic population-based pharmacy database. Persistence was assessed using the gap method. Kaplan-Meier and Cox regression analyses were con
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Nugraha, Dimas Pramita, Iwan Dwiprahasto, and Jarir At Thobari. "Compliance Pengguna Antihipertensi di RSUP DR. SARDJITO Yogyakarta (Periode Juli 2006- Juni 2009)." Jurnal Ilmu Kedokteran 8, no. 2 (2017): 70. http://dx.doi.org/10.26891/jik.v8i2.2014.70-75.

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Hypertension is the second largest of the 10 diseases on an outpatient at a hospital in Indonesia. The poor complianceto therapy of hypertension is a major cause of uncontrolled blood pressure. The aim of this study is to determinecompliance antihypertension on patient at DR. Sardjito hospital Yogyakarta. This study was designed with aretrospective cohort study design using a database of participants claimed prescribing health insurance (ASKES) inthe DR. Sardjito hospital using antihypertensive drugs. Compliance measured with medication possession ratio (MPR).Data was analysed by chi- square a
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Junusbekova, Gulnara, Meiramgul Tundybayeva, Tatyana Leonovich, et al. "The optimal combination of Lysinopril and Amlodipine for the treatment of patients with hypertension." Journal "Medicine" 1-2, no. 211-212 (2020): 31–39. http://dx.doi.org/10.31082/1728-452x-2020-211-212-1-2-31-39.

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Arterial hypertension (AH) remains one of the most common diseases in the world. Reducing cardiovascular risk of mortality from cardiovascular complications is a priority in the treatment of hypertension. Targets of hypertension therapy is to achieve SBP/DBP <140/80 mm Hg. article, regardless of cardiovascular risk and comorbidity. The choice of antihypertensive therapy depends on blood pressure levels, the presence or absence of concomitant diseases, lesion of target organs. Effective and long-lasting control of AH proved by the use of combinations of antihypertensive drugs, including anta
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32

Levchenkova, O. S., R. R. Galimulina, B. R. Komev, and K. D. Zagnet. "Choice Between Free Combination of Antihypertensive Agents and Fixed Dosed Combinations in the Treatment of Arterial Hypertension." Russian Archives of Internal Medicine 14, no. 5 (2024): 325–38. http://dx.doi.org/10.20514/2226-6704-2024-14-5-325-338.

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Most patients with arterial hypertension require more than one antihypertensive drug for blood pressure target achievement. Some patients are recommended for a multi-pill antihypertensive regimen, others — treatment with fixed dosed combinations in one tablet. Analysis of elibrary and PubMed publications in the period mostly from 2014 to 2024 concerning the choice of two-component combined antihypertensive agents containing renin-angiotensin system inhibitor and diuretic or calcium channel blocker, revealed that fixed-dose combinations (FDC) use and taking one tablet once a day improves adhere
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Morozova, T. E., and E. O. Samokhina. "Fixed-dose combinations in the treatment of hypertension to increase adherence." Russian Journal of Cardiology 25, no. 11 (2020): 4184. http://dx.doi.org/10.15829/29/1560-4071-2020-4184.

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Despite a wide range of antihypertensive drugs, blood pressure (BP) control often remains unsatisfactory, and every year the number of people with uncontrolled high BP increases. One of the strategies aimed at improving medical adherence is the use of fixed-dose combinations of 2 antihypertensive drugs for starting therapy, and, if necessary, 3 drugs. Initiation of therapy with 2 drugs in one tablet is recommended for most patients. A review of algorithms for choosing combinations of antihypertensive drugs in different clinical situations, including in patients with various comorbid conditions
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Husna, Nadia, and Niken Larasati. "EVALUASI PENGGUNAAN TERAPI ANTIHIPERTENSI PADA PASIEN GAGAL GINJAL KRONIK DENGAN HEMODIALISIS." MEDIA ILMU KESEHATAN 8, no. 1 (2019): 1–8. http://dx.doi.org/10.30989/mik.v8i1.249.

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Background: End Stage Renal Disease (ESRD) occurs when Glomerular Filtration Rate (GFR) falls below 15 ml/minute/1.73m2. This condition leads to Renal Replacement Therapy (RRT) intervention namely dialysis and kidney transplantation. The intervention inclines morbidity and hospitalization rate which means more physical and financial burden to patients as the consequences. One of the physical side effects that becomes a major cause of increasing cardiovasculer mortality is hypertension.
 Objective: The purpose of this study was to analyze the rationale of antihypertensive therapy in haemod
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Husna, Nadia, and Niken Larasati. "EVALUASI PENGGUNAAN ANTIHIPERTENSI PADA PASIEN GAGAL GINJAL KRONIK DENGAN HEMODIALISIS DI RUMAH SAKIT PKU MUHAMMADIYAH GAMPING YOGYAKARTA." Media Ilmu Kesehata 8, no. 1 (2019): 1–8. http://dx.doi.org/10.30989/mik.v8i1.337.

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Background: End Stage Renal Disease (ESRD) occurs when Glomerular Filtration Rate (GFR) falls below 15 ml/minute/1.73m2. This condition leads to Renal Replacement Therapy (RRT) intervention namely dialysis and kidney transplantation. The intervention inclines morbidity and hospitalization rate which means more physical and financial burden to patients as the consequences. One of the physical side effects that becomes a major cause of increasing cardiovasculer mortality is hypertension.
 Objective: The purpose of this study was to analyze the rationale of antihypertensive therapy in haemod
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36

Yuswantina, Richa, Niken Dyahariesti, and Diastri Dwi Ambarwati. "Study of the Cost Effectiveness of Therapy in Hypertention Patients in Hospital." Jurnal Midpro 15, no. 1 (2023): 62–68. http://dx.doi.org/10.30736/md.v15i1.456.

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Hypertension is where the blood pressure is > 140 mmHg and > 90 mmHg. Combination therapy is needed if a single antihypertensive has not been able to control the desired blood pressure target while the cost of treatment is increasing from time to time. The purpose of this study was to determine the cost-effective combination therapy for antihypertensive drugs in hypertensive patients in an inpatient setting. This study is a descriptive study with a pharmacoeconomic analysis approach using the Cost Effectiveness Analysis (CEA) method which was carried out retrospectively. Data were collec
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Povetkin, S. V., and A. A. Kornilov. "Fixed drug combinations as a way of complex antihypertensive therapy optimization: focus on the combination of amlodipine, indapamide, perindopril." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 28, no. 1 (2022): 17–26. http://dx.doi.org/10.18705/1607-419x-2022-28-1-17-26.

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This article is an analysis of current data on arterial hypertension (HTN) as a leading risk factor for premature death. We discuss the reasons of the failure to achieve target levels of blood pressure, and the available approaches to HTN pharmacological treatment by the main classes of antihypertensive drugs in accordance with current clinical guidelines. We show the advantages of fixed combinations (FC) of antihypertensive drugs and the ways to optimize antihypertensive treatment by administration of a triple FC, containing amlodipine, indapamide and perindopril.
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Morozova, T. E., T. B. Andrushchishina, and I. Yu Yudina. "Combined pharmacotherapy of arterial hypertension. Overview fixed combination antihypertensive drugs." Systemic Hypertension 13, no. 3 (2016): 58–63. http://dx.doi.org/10.26442/sg29153.

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Hypertension remains the cornerstone of the cardiovascular continuum. An increasing number of patients receive a combination antihypertensive therapy to achieve target blood pressure, expanding indications for combination therapy at the onset of treatment. Constantly growing market of fixed combinations (FC) of antihypertensive drugs. The article gives an overview of the FC, registered in the Russian Federation, discussed the clinical situation for the preferential destination of a FC. A more detailed analysis of FC comprising the angiotensin II receptor blocker and diuretics, in particular, d
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Khamdiyah Indah Kurniasih, Nanang Munif Yasin, and Pri Iswati Utami. "Comparative Effectiveness of Single Versus Combination Antihypertensive Therapy in PROLANIS Hypertension Patients: A Retrospective Study in Purbalingga Regency." Archives of The Medicine and Case Reports 5, no. 4 (2024): 1000–1015. http://dx.doi.org/10.37275/amcr.v5i4.625.

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The PROLANIS program in Indonesia aims to manage chronic diseases like hypertension. While combination antihypertensive therapy is recommended for many patients, evidence on its effectiveness in the PROLANIS setting remains limited. This study investigated the comparative effectiveness of single versus combination antihypertensive therapy in achieving blood pressure control among PROLANIS hypertension patients in Purbalingga Regency. A retrospective cohort study was conducted using data from PROLANIS hypertension patients in Purbalingga Regency from January-December 2023. Patients were categor
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Naser, Nabil, Zaim Jatic, and Sevleta Avdic. "The Effects of Single Pill Combinations on Adherence and Blood Pressure Control in Hypertensive Patients." Materia Socio Medica 34, no. 2 (2022): 130. http://dx.doi.org/10.5455/msm.2022.34.130-135.

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Background: Hypertension is the most important risk factor for cardiovascular morbidity and mortality. Blood pressure control rates are as low as 17% to 31% in patients diagnosed with hypertension in high-income countries; control rates are likely poorer in low- to middle- and low-income countries. Blood pressure control rates are as low as 17% to 31% in patients diagnosed with hypertension in high-income countries; control rates are likely poorer in low- to middle- and low-income countries. Overall, 43% to 66% of patients fail to adhere to their prescribed antihypertensive medications, and af
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Chazova, I. E., and T. V. Martyniuk. "Diuretics in combination antihypertensive therapy: focus on forecast." Systemic Hypertension 13, no. 2 (2016): 6–10. http://dx.doi.org/10.26442/sg29120.

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In the modern therapy of arterial hypertension (AH) along with thiazide diuretics b-blockers, calcium antagonists, angiotensin converting enzyme inhibitors and angiotensin receptor blockers are considered for initial and maintenance of antihypertensive therapy in the form of mono - or combination therapy. Five of these classes of drugs have comparable antihypertensive effectiveness and proven impact on prognosis in accordance with the results of randomized controlled clinical trials. The most widely used in clinical practice for the treatment of patients with AH received thiazide diuretics. Th
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42

Kislyak, O. A. Kislyak, M. N. Davydenko Davydenko, S. L. Postnikova Postnikova, and E. V. Moiseeva Moiseeva. "Effect of Combination Antihypertensive Therapy Central Blood Pressure." Kardiologiia 4_2015 (April 27, 2015): 67–70. http://dx.doi.org/10.18565/cardio.2015.4.67-70.

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43

MATERSON, B. "Rationale for initial therapy with combination antihypertensive agents." American Journal of Hypertension 17, no. 5 (2004): S246. http://dx.doi.org/10.1016/j.amjhyper.2004.03.658.

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44

Pattan, S. R., A. O. Zanwar, N. B. Wabale, and U. B. Shetkar. "SCOPE AND NEED OF COMBINATION OF ANTIHYPERTENSIVE DRUGS." INDIAN DRUGS 49, no. 05 (2012): 5–19. http://dx.doi.org/10.53879/id.49.05.p0005.

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The recommendation for first-line therapy for hypertension remains a beta blocker or diuretic given in a low dosage. A target blood pressure of less than 140/90 mm Hg is achieved in about 50 percent of patients treated with monotherapy; two or more agents from different pharmacological classes are often needed to achieve adequate blood pressure control. Single-dose combination antihypertension therapyis an important option that combines efficacy of blood pressure reduction and a low side effect profilewith convenient once-daily dosing to enhance compliance. Combination antihypertensives includ
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45

Karpov, Y. A., and O. S. Bulkina. "COMBINATION THERAPY OF AH IN CLINICAL PRACTICE." Medical Council, no. 7 (December 30, 2017): 20–27. http://dx.doi.org/10.21518/2079-701x-2017-7-20-27.

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High blood pressure (BP) is thr major independent risk factor for cardiovascular disease and the associated high mortality in this country. [1] Arterial hypertension (AH) is often called the silent killer because the disease may proceed without any symptoms and does not manifest itself until the occurrence of severe complications - myocardial infarction or cerebrovascular disease. However, there is convincing evidence for the forecast improvement with regular use of antihypertensive drugs, while achievement of blood pressure control (target level) is a crucial factor in reducing the risk of fa
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Zhao, Xiexiong, Tao Liu, Qiong Yang, et al. "P110 INITIAL TREATMENT WITH A SINGLE CAPSULE CONTAINING HALF-DOSE QUADRUPLE THERAPY VS STANDARD-DOSE DUAL THERAPY IN HYPERTENSIVE PATIENTS (QUADUAL): A RANDOMIZED, BLINDED, CROSSOVER TRIAL." Journal of Hypertension 42, Suppl 3 (2024): e97. http://dx.doi.org/10.1097/01.hjh.0001063312.90423.33.

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Background and Objective: Guidelines recognized the dual combination in initial antihypertensive therapy. Studies demonstrated low-dose quadruple combination antihypertensive was superior to monotherapy. However, whether low-dose quadruple therapy is better than dual combination is unknown. Methods: A randomized blinded crossover trial was conducted to compare the efficacy and safety of low-dose quadruple antihypertensives (irbesartan 75 mg + metoprolol 23·75 mg + amlodipine 2·5 mg + indapamide 1·25 mg) with standard-dose dual antihypertensives (irbesartan 150 mg + amlodipine 5 mg) in the init
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Glukhova, T. V., S. A. Solgalova, and V. V. Alferov. "Antihypertensive efficacy of a fixed full-dose perindopril A-indapamide combination in patients with grades 2–3 arterial hypertension." Systemic Hypertension 10, no. 1 (2013): 66–69. http://dx.doi.org/10.26442/sg28953.

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Aim: to study the antihypertensive efficacy of a fixed full-dose perindopril arginine-indapamide combination in patients with grades 2–3 arterial hypertension (AH) who do not receive antihypertensive therapy or those who do not achieve blood pressure (BP) control with other antihypertensive drugs. Subjects and methods. The trial enrolled 30 patients: 20 (66,6%) males and 10 (33,3%) females aged 30 to 60 years (mean age 50,5±7,1 years). Grades 2 and 3 AH was recorded in 28 (93,3%) and 2 (6,6%) patients, respectively. According to office measurements, the baseline BP (systolic BP (SBP)/diastolic
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Ostroumova, O. D., A. I. Kochetkov, A. V. Starodubova, I. V. Goloborodova, and E. A. Smolyarchuk. "TRIPLE ANTIHYPERTENSIVE THERAPY: FOCUS ON EFFICACY AND PROGNOSIS." Rational Pharmacotherapy in Cardiology 14, no. 3 (2018): 458–68. http://dx.doi.org/10.20996/1819-6446-2018-14-3-458-468.

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In the article, with regard to current clinical recommendations, the place of combined antihypertensive therapy, especially triple drugs regimens, is considered in the treatment of patients with arterial hypertension. Special focus is given to the body of evidence for the efficacy of valsartan and amlodipine, as the reference drug of angiotensin II receptor blockers and calcium channel blockers, respectively. Not only their high antihypertensive properties are demonstrated, but also a favorable effect on target-organ protection and prognosis is described. In particular, the possibilities of va
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Chukaeva, I. I. "Adherence and benefits of full-dose combination of antihypertensive drugs." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 18, no. 1 (2012): 46–51. http://dx.doi.org/10.18705/1607-419x-2012-18-1-46-51.

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Control over blood pressure is an existing problem in cardiology and does not exceed 30 % for Europeans, despite prevalence and availability of effective antihypertensive drugs. Low adherence to treatment is one of the reasons of low control of blood pressure. Implementation of the combined antihypertensive drugs with the high fixed doses allows to simplify therapy in subjects receiving combination therapy and to increase the adherence in high risk patients receiving drugs separately.
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Kirsanov, A. I., I. A. Gorbacheva, and L. A. Shestakova. "Clinical Efficacy of foxed low-dose perindopril-indapamide combination in the elderly." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 12, no. 3 (2006): 244–47. http://dx.doi.org/10.18705/1607-419x-2006-12-3-244-247.

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The study addresses antihypertensive effects of fixed low-dose perindopril-indapamide combination therapy in the elderly hypertensive patients. Combinations with metoprolol were also studied. Is was shown that antihypertensive effect can be observed ay second week of treatment and is dose-dependent. Besides, additional administration of metoprolol 50 mg per day was not associated with further blood pressure decrease but resulted in significant heart rate reduction.
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