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Rozprawy doktorskie na temat „Antimalarials”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Meurer, Michael. "Childhood Discoid Lupus erythematosus and Antimalarials." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135574.

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2

Al-Tayib, Yousuf A. "Oxidative hepatic metabolism of cinchona antimalarials." Thesis, University of Bradford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304177.

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3

Rajab, M. "Investigating calcium channel blockers as antimalarials." Thesis, University of Salford, 2018. http://usir.salford.ac.uk/47791/.

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The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford identified calcium channel blockers (CCBs) as potential antimalarial agents. A growing body of evidence has demonstrated the importance of calcium within the <I>Plasmodium</I> life cycle. Studies have shown CCBs and calmodulin inhibitors to exhibit antimalarial activity. The research carried out in this project aims to evaluate the antimalarial efficacy

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4

Meurer, Michael. "Childhood Discoid Lupus erythematosus and Antimalarials." Karger, 2003. https://tud.qucosa.de/id/qucosa%3A27661.

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5

Nicoleti, Nélio Henrique [UNESP]. "Estrutura eletrônica de materiais orgânicos: moléculas antimalariais de sulfonamidas e anilinoquinolinas." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/88499.

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Made available in DSpace on 2014-06-11T19:23:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-05-11Bitstream added on 2014-06-13T20:10:54Z : No. of bitstreams: 1 nicoleti_nh_me_bauru.pdf: 1244120 bytes, checksum: 82b0fc15919f6c3214248fe48efec3e6 (MD5)<br>Neste trabalho estudamos dois grupos de moléculas: as anilinoquinolinas e as sulfonamidas, inibidores do Plasmodium causador da malária, com o objetivo de correlacionar a estrutura eletrônica com a atividade antimalarial. Em nossas buscas utilizamos métodos empíricos e semi-empíricos para o estudo conformacional e obtenção dos descr

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6

Zindrou, Sherwan. "Molecular diagnosis of drug resistance in Plasmodium falciparum and virulence factors in Entamoeba histolytica /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4304-4/.

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7

Hayes, Daniel Joseph. "Developing age-based dosing regimens for antimalarials." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570625.

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Introduction. Age-based dosing of antimalarials is a widely used alternative to weight-based dosing practices. However, it is rarely taken into account in the drug development phase and standardized methods to devise age-based proxies that optimize the effectiveness and safety of antimalarial drugs do not exist. This has contributed to the variation in existing age-based regimens for antimalarials, at times resulting in poor, but widely-used regimens. Inaccurate dosing poses a threat to the individual (treatment failure, adverse effects) and the population (emergence and spread of resistance).

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8

Molyneaux, Carrie-Anne. "Antimalarials based on the arylpiperazine privileged substructure." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/6342.

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Includes bibliographical references (leaves 118-124).<br>Based on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain. In other studies, 8-hydroxy-2-(di-n-propylamino)tetralin (8-0H-DPAT) has been identified as a potential antimalarial agent for the inhibition of the 5-hydroxytryptamine type 1A receptor in Plasmodium falciparum. A number of arylpiperazines are also known to target this receptor in oth

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9

Tan, Bee San Fleckenstein Lawrence L. "Population pharmacokinetics of artesunate and its active metabolite dihydroartemisinin." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/442.

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10

Duraisingh, Manoj Theodore. "Characterisation of resistance to artemisinin in Plasmodium falciparum." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322662.

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11

Johnson, David James. "Studies on the molecular basis of chloroquine resistance in Plasmodium falciparum." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273985.

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12

Al-Mohammadi, Abdul-Raouf A. "The diamidines as antimalarials : determinant of drugs activity." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414805.

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13

Merette, Sandrine Annick Michelle. "Synthesis and pharmacological evaluation of novel potential antimalarials." Thesis, University of Hertfordshire, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394078.

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14

Alhewaitey, Anaif. "Interactions of aurein with model membranes and antimalarials." Thesis, Tennessee State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10119062.

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<p> Aurein is a cationic antimicrobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its mechanism of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with model biological membranes and antimalarials using Fourier Transform Infrared (FTIR), fluorescence, dynamic light scattering (DLS), atomic force microscopy (AFM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) techniques. FTIR data revealed conformational changes to the secondary structure o

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15

Murphy, Kevin Vincent. "Design and Synthesis of Novel Chloroquine-based Antimalarials." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2623.

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Malaria is an infectious, often fatal disease that afflicts nearly 200 million people every year. The disease, characterized by recurring and extreme flu-like symptoms, is caused by the protozoan parasite Plasmodium falciparum. Victims usually contract the disease through a mosquito vector. Chloroquine is a chemotherapeutic that was introduced in the 1940s. For many years the drug was the foremost treatment of malaria, being effective and producing few side effects. Unfortunately, tolerance to chloroquine developed when the parasite evolved a resistance mechanism. Newer drugs have been develop

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16

Adendorff, Matthew Ralph. "Marine anti-malarial isonitriles : a synthetic and computational study." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1006674.

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The development of Plasmodium falciparum malarial resistance to the current armoury of anti-malarial drugs requires the development of new treatments to help combat this disease. The marine environment is a well established source of potential pharmaceuticals. Of interest to us are isonitrile, isocyanate and isothiocyanate compounds isolated from marine sponges and molluscs which have exhibited nano-molar anti-plasmodial activities. Through quantitative structure-activity relation studies (QSAR), a literature precedent exists for a pseudoreceptor model from which a pharmacophore for the design

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17

Zhou, Qun. "Antitumor activity of antimalarials in human breast cancer cells." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2275.

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Thesis (Ph. D.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains viii, 146 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 125-142).

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18

Liu, Yungen. "Synthesis, cytotoxicity and proteomics studies of artemisinin derivatives." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38024184.

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19

Ho, Wing Yan. "Studies on molecular mechanism of action and synthesis of new derivatives of the antimalarial drug artemisinin /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202004%20HOW.

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20

Warner, Jacqueline Anne. "Examination of biosynthetic models for the formation of prostaglandins and naturally occurring antimalarial compounds." Thesis, The University of Sydney, 1993. https://hdl.handle.net/2123/26630.

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The following work investigates two mechanistic proposals for the metal-catalysed reactions of allylic hydroperoxides. A heterolytic mechanism, involving bond migration, and a radical mechanism, involving a peroxy radical intermediate were considered. A study of the cleavage reaction of cyclic allylic hydroperoxides indicated that the outcome was substrate and catalyst dependent. Treatment of the six membered cyclic allylic hydroperoxide 129 with various metal catalysts led to the formation of the aldol 131 as the major product. However, similar treatment of the ﬁve-membered cyclic allylic hyd

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21

Aviña-Zubieta, Juan Antonio. "The long-term effectiveness of antimalarials in rheumatic diseases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq21151.pdf.

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22

Shone, Alison Emily. "The synthesis and metabolism of novel 4-aminoquinoline antimalarials." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443926.

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23

Urch, Jonathan Edward. "Fatty acid synthesis as a target for new antimalarials." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55947/.

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Malaria can be regarded as one of the world's worst health problems and its incidence is rising inexorably. It already accounts for the deaths of approximately three children every minute. This situation is exacerbated by the increased frequency of parasite resistance to current antimalarial agents and necessitates the development of new drugs to combat this disease P. falciparum possesses a plastid-like organelle, termed the apicoplast, which contains a small, highly reduced 35kb genome encoding tRNA, DNA polymerases and ribosomal proteins. Nuclear proteins are targeted to the apicoplast usin

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24

Urbán, Patricia. "Development of nanovectors for the targeted drug delivery of antimalarials." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/104509.

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Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease, and the complexity of the life cycle of its causative agent, the protozoan Plasmodium sp. The clinical, social and economic burden of malaria has led for the last 100 years to several waves of serious efforts to reach its control and eventual eradication, without success to this day. At present, administration methods of antimalarial drugs release the free compound in the blood stream, from where it can be significantly removed by many tissues and organs, t

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25

Brown, Mary Catherine. "The impact of side effects on travellers' compliance with antimalarials." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29663.pdf.

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26

Brown, Mary Catherine 1964. "The impact of side effects on travellers' compliance with antimalarials /." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35308.

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The association between side effects to antimalarial chemoprophylaxis and noncompliance was assessed in travellers visiting five pre-travel clinics in the greater Montreal area between February and August 1996. Participants completed pre and post-travel questionnaires to ascertain frequency and severity of side effects and compliance with malaria chemoprophylaxis. A participation rate of 83% was achieved. Of 157 travellers prescribed mefloquine and 132 travellers prescribed chloroquine, proportions experiencing symptoms or side effects were high (7% and 83%, respectively), but not statisticall

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27

Saif, A. M. "Pharmacology and pharmacodynamics of selected antimalarials against P. falciparum gametocytes." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3005700/.

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Malaria is a vector-borne disease that is still responsible for high human morbidity and mortality. Of the five Plasmodium species that can cause malaria in humans, Plasmodium falciparum is regarded the most virulent species. The most fundamental component of sustained control and eradication efforts is the development of effective drugs for malaria treatment and prophylaxis. Plasmodium falciparum’s sexual stages (gametocytes) are not associated with malarial pathogenesis or the clinical symptoms, but they are responsible for the transmission of the disease from human hosts to mosquitos. As su

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28

Obua, Celestino. "Fixed-dose chloroquine and sulfadoxine/pyrimethamine treatment of malaria : outcome and pharmacokinetic aspects /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-144-9/.

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29

Chan, Wing Chi. "Chemical studies on mechanism of action of the Chinese antimalarial artemisinin and its derivatives /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202005%20CHAN.

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30

Hui, Shi-man. "Investigation of synthetic routes to postulated biosynthetic intermediates of artemisinin /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19473084.

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31

Hesping, Eva M. "New inhibitors and tools to advance HDAC drug discovery for malaria." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/403646.

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Malaria is a leading cause of morbidity and mortality, causing more than 400,000 deaths per year. Malaria is caused by parasites of the Plasmodium genus with most deaths due to P. falciparum infection. The control of malaria is complicated by the lack of a widely effective vaccine, the spread of mosquito resistance to insecticides and Plasmodium parasite resistance to available drugs, including the gold standard artemisinin-combination therapies. Thus, there is an urgent requirement for the development of new antimalarials, in particular those with different modes of action to existing drugs t

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32

Alvarado, Stephenie M. "Identification of novel antimalarials from marine natural products for lead discovery." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4591.

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An estimated 500 million cases of malaria occur each year. The increasing prevalence of drug resistant strains of Plasmodium in most malaria endemic areas has significantly reduced the efficacy of current antimalarial drugs for prophylaxis and treatment of this disease. Therefore, discovery of new, inexpensive, and effective drugs are urgently needed to combat this disease. Marine biodiversity is an enormous source of novel chemical entities and has been barely investigated for antimalarial drug discovery. In an effort to discover novel therapeutics for malaria, we studied the antimalarial act

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33

Davies, Matthew. "Design and synthesis of new dihydroorotate dehydrogenase inhibitors as potential antimalarials." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439572.

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34

Thirumalairajan, Srinath. "Design and synthesis of enzyme inhibitors as potential antibacterials and antimalarials." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417729.

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35

Ruscoe, Julie Elizabeth. "The effect of disposition on the pharmacology and toxicology of antimalarials." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337126.

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36

許士敏 and Shi-man Hui. "Investigation of synthetic routes to postulated biosynthetic intermediates of artemisinin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31215324.

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37

Ho, Kin-fai Gary, and 何健輝. "The biogenesis of artemisinin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31226036.

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38

Janneh, Omar. "The role of the haemoglobin degradation pathway in the uptake and activity of antimalarial drugs in Plasmodium falciparum." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367827.

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39

Jones, Karen. "The basis for naphthoquinone and biguanide synergy." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368631.

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40

Munedzimwe, Tatenda Carol. "The isolation, quantification and synthetic modification of antiplasmodial natural products from sargassum heterophyllum." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1018252.

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Malaria is one of the most deadly parasitic diseases known to man. Although the number of malaria cases reported each year is decreasing, this disease continues to pose health and economic problems mainly in developing countries. Significant progress has been made in the fight against this disease. This includes the discovery and development of potent antimalarial agents. However, the development of resistance to most of these potent antimalarials has made the development of new antiplasmodial agents of paramount importance. Several promising antiplasmodial agents have been found from the mari

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41

Phisit, Prapunwattana Yongyuth Yuthavong. "Mechanism of antimalarial action of tetracycline /." abstract, 1986. http://mulinet3.li.mahidol.ac.th/thesis/2529/29E-Phisit-P.pdf.

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42

Blessborn, Daniel. "Development of Analytical Methods for the Determination of Antimalarials in Biological Fluids." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108767.

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The aim of this thesis was to develop analytical methods for measuring antimalarial drugs in biological fluids. Solid phase extraction (SPE) was used for the enrichment and purification of the drugs. Automatic extraction procedures using a SPE robot were developed to reduce the workload for the analyst and to minimize variations in the extraction procedure. Liquid chromatography (LC) with either UV or mass spectrometric (MS) detection was used to determine sample concentrations. Determination of Pyronaridine in whole blood utilised a weak cation exchanger to extract Pyronaridine from blood. To

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43

Ganazzoli, Giacomo. "Quantum dot labelled antimalarials and investigation of their interaction with synthetic haemozoin." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29749.

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Chloroquine (CQ) is a well-known antimalarial drug acting through the inhibition of the formation of haemozoin crystals in the Plasmodium parasite’s digestive vacuole within human infected red blood cells. The formation of haemozoin is considered a defence strategy of the parasite in order to decrease the levels of toxic ferriprotoporphyrin (Fe(III)PPIX) present in the DV. Chloroquine is supposed to be adsorbed onto the fastest growing face of the crystal, inhibiting the growth and increasing the amount of toxic Fe(III)PPIX; however, the mechanism of this interaction is still largely unproven.

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44

Eriksen, Jaran. "Managing childhood malaria in rural Tanzania : focusing on drug use and resistance /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-678-6/.

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45

De, Jager Josephus Jacobus. "Design and synthesis of novel antimalarial agents." Thesis, Stellenbosh : Stellenbosh University, 2014. http://hdl.handle.net/10019.1/96071.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Malaria is a pestilent disease associated with massive socioeconomic burden of sub-Saharan Africa. This disease is caused by a blood infection of the single cellular parasite of the Plasmodium genus. Two enzymes of this parasite have been identified to be essential to the survival of this parasite, notably Spermidine Synthase and Protein Farnesyltransferase. The goal of this dissertation was to search for and synthesise novel inhibitors of these two enzymes with a strong focus towards understanding their structure/activity relat

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46

Gupta, Seema. "Experimental pharmacodynamic and kinetic studies related to new combination therapies against falciparum malaria /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-066-4/.

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Hla, Yin Myint Sasithon Pukrittayakamee. "A systematic overview of published antimalarial drug trials /." Abstract, 2003. http://mulinet3.li.mahidol.ac.th/thesis/2546/46E-Hla-Y.pdf.

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Bartley, Paul Benedict. "Artemether and the immunobioology of schistosomiasis japonica /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18411.pdf.

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49

Mbere, Johana M. "Development of new benzo[b]thiophene amide-based antimicrobial agents." Department of Chemistry - Faculty of Science, 2005. http://ro.uow.edu.au/theses/396.

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The overall aim of this project was to investigate the synthesis and activity of a range of compounds based on the benzo[b]thiophene-2-carboxamide structural motif as potential new antimalarial agents, and to a lesser extent as antibacterial agents.In order to subsequently explore any structure-biological activity relationships, the first part of the project involved the systematic synthesis of some 39 non-fused substituted benzo[b]thiophene amide derivatives including tetrahydroisoquinolines, tetrahydro-β-carbolines, dihydropyrroles, piperazines, piperidines and other bridged ring systems as

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50

Liu, Yungen, and 劉運根. "Synthesis, cytotoxicity and proteomics studies of artemisinin derivatives." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38861483.

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