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Artykuły w czasopismach na temat „Antimycobacterial susceptibility testing”

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Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Griffith, M. E., and H. L. Bodily. "Stability of antimycobacterial drugs in susceptibility testing." Antimicrobial Agents and Chemotherapy 36, no. 11 (1992): 2398–402. http://dx.doi.org/10.1128/aac.36.11.2398.

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Sánchez, Juan Gabriel Bueno, and Vladimir V. Kouznetsov. "Antimycobacterial susceptibility testing methods for natural products research." Brazilian Journal of Microbiology 41, no. 2 (2010): 270–77. http://dx.doi.org/10.1590/s1517-83822010000200001.

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Inderlied, C. B. "Antimycobacterial susceptibility testing: Present practices and future trends." European Journal of Clinical Microbiology & Infectious Diseases 13, no. 11 (1994): 980–93. http://dx.doi.org/10.1007/bf02111499.

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K, Kalaiselvi, Mangayarkarasi V, Gomathi Ns, Balaji S, Shivshankar R. Mane, and Raja Shunmugam. "LUCIFERASE REPORTER MYCOBACTERIOPHAGES FOR EVALUATING NORBORNENE-BASED ANTITUBERCULOSIS DRUG SUSCEPTIBILITY TESTING ON MYCOBACTERIUM TUBERCULOSIS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 9 (2017): 406. http://dx.doi.org/10.22159/ajpcr.2017.v10i9.19660.

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Objective: In 2015, 9.6 million people around the world became sick with tuberculosis (TB) disease and 1.5 million TB-related deaths worldwide. Recent increasing incidence of multidrug-resistant (MDR; resistance to at least rifampicin (RIF) and isoniazid [INH]) and extensively drug-resistant (MDR resistance plus resistance to a fluoroquinolone and an aminoglycoside) makes TB a serious concern. Lot of research is needed to deal with this infectious disease for a better alternative in treatment or modification of these older TB drugs. The present study aimed at evaluating antimycobacterial activ
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Washington, J. A. "Functions and activities of the Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards." Clinical Microbiology Reviews 4, no. 2 (1991): 150–55. http://dx.doi.org/10.1128/cmr.4.2.150.

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The Area Committee on Microbiology of the National Committee for Clinical Laboratory Standards has responsibility for the development of guidelines and standards in the field of clinical microbiology. Through the consensus process, representatives from government, industry, and professional societies have developed standards on antibacterial susceptibility testing (M2, M7, and M11), antimycobacterial susceptibility testing (M24), quality assurance on commercially prepared microbiological culture media (M22), evaluation of production lots of dehydrated Mueller-Hinton agar (M6), and preparation
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Moore, Andrea V., Scott M. Kirk, Steven M. Callister, Gerald H. Mazurek, and Ronald F. Schell. "Safe Determination of Susceptibility of Mycobacterium tuberculosis to Antimycobacterial Agents by Flow Cytometry." Journal of Clinical Microbiology 37, no. 3 (1999): 479–83. http://dx.doi.org/10.1128/jcm.37.3.479-483.1999.

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We showed previously that susceptibility testing forMycobacterium tuberculosis labeled with fluorescein diacetate could be accomplished rapidly by using flow cytometry. However, safety was a major concern because mycobacteria were not killed prior to flow cytometric analysis. In this study, we developed a biologically safe flow cytometric susceptibility test that depends on detection and enumeration of actively growing M. tuberculosis organisms in drug-free and antimycobacterial agent-containing medium. The susceptibilities of 17 clinical isolates of M. tuberculosis to ethambutol, isoniazid, a
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Schoutrop, Esther L. M., Michelle A. E. Brouwer, Josien C. A. Jenniskens, et al. "The stability of antimycobacterial drugs in media used for drug susceptibility testing." Diagnostic Microbiology and Infectious Disease 92, no. 4 (2018): 305–8. http://dx.doi.org/10.1016/j.diagmicrobio.2018.06.015.

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Singh, Ashok K., Shailendra K. Singh, Kavita Dhariyal, Ram Kumar, Amarendra Kumar, and Sudheer K. Singh. "Synthesis, Characterization and Antimycobacterial Activity of Phenanthrenequinone Thiosemicarbazones and their Ruthenium and Zinc Complexes." Asian Journal of Chemistry 33, no. 5 (2021): 983–88. http://dx.doi.org/10.14233/ajchem.2021.23127.

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The substituted phenanthrenequinone thiosemicarbazones (HL1, HL2 and HL3), and their metal complexes (M = Ru(II) or Zn(II); SM1, SM2, SM3 and SM4) were synthesized and characterized by FT-IR, 1H & 13C NMR and ESI-MS. The spectral data IR, 1H & 13C NMR and ESI-MS indicates two tridentate ligands coordinating in the form of an octahedral geometry. The gas phase geometry of all the zinc(II) and ruthenium(II) complexes was carried by using density functional theory (DFT). The antimycobacterial susceptibility testing at 100 μM of the complexes using resazurin microtiter plate assay resulted
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9

Sankar, Manimuthu, Krishnamoorthy Gopinath, Roopak Singla, and Sarman Singh. "In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay." Annals of Clinical Microbiology and Antimicrobials 7, no. 1 (2008): 15. http://dx.doi.org/10.1186/1476-0711-7-15.

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10

Guay, David RP. "Nontuberculous Mycobacterial Infections." Annals of Pharmacotherapy 30, no. 7-8 (1996): 819–30. http://dx.doi.org/10.1177/106002809603000721.

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OBJECTIVE: To review the epidemiology, clinical manifestations, diagnosis, and treatment of nontuberculous mycobacterial infections other than Mycobacterium avium complex (MAC). DATA SOURCES: A MEDLINE search of English-language literature pertaining to nontuberculous mycobacteria other than MAC was performed. Additional literature was obtained from reference lists of pertinent articles identified through the search. STUDY SELECTION AND DATA EXTRACTION: All articles were considered for possible inclusion in the review. Information judged by the author to be pertinent was selected for discussio
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11

Doležal, Martin, Jiří Hartl, Antonín Lyčka, Vladimír Buchta, and Želmíra Odlerová. "Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides." Collection of Czechoslovak Chemical Communications 61, no. 7 (1996): 1102–8. http://dx.doi.org/10.1135/cccc19961102.

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A series of N-substituted 3-amino-5-thiocarbamoyl-2-pyrazinecarboxamides was prepared. The structure of compounds was confirmed by elemental analysis, IR and 1H NMR spectra. The results of in vitro antifugal and antimycobacterial susceptibility testing shown no activity against pathogenic fungi and some effect on mycobacteria. The highest antituberculotic activity (MIC within 25-50 mg ml-1) against Mycobacterium tuberculosis and other mycobacterial strains in this series was shown by 3-(3-hydroxyphenylamino)-5-thiocarbamoyl-2-pyrazinecarboxamide. The antituberculotic activity of these compound
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12

Borek, Anna, Anna Zabost, Agnieszka Głogowska, Dorota Filipczak, and Ewa Augustynowicz-Kopeć. "New RAPMYCOI SensititreTM Antimicrobial Susceptibility Test for Atypical Rapidly Growing Mycobacteria (RGM)." Diagnostics 12, no. 8 (2022): 1976. http://dx.doi.org/10.3390/diagnostics12081976.

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Rapidly growing mycobacteria (RGM) cause an increasing international concern, mainly due to their natural resistance to many antibiotics. The aim of this study was to conduct species identification and determine the antimicrobial susceptibility profiles of RGM isolated in Poland. Antimicrobial susceptibility was tested using broth microdilution and the RAPMYCOI panel. A total of 60 strains were analysed, including the following species: M. fortuitum complex (30), M. abscessus subsp. abscessus (16), M. abscessus subsp. massiliense (7), M. chelonae (5), and M. mucogenicum (2). For 12 M. abscessu
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13

Peloquin, Charles A. "Controversies in the Management of Mycobacterium Avium Complex Infection in AIDS Patients." Annals of Pharmacotherapy 27, no. 7-8 (1993): 928–37. http://dx.doi.org/10.1177/106002809302700722.

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OBJECTIVE: To update readers on the clinical management of infections secondary to Mycobacterium avium complex (MAC) in patients with AIDS. A general description of the organism, culture and susceptibility testing, and clinical manifestations of the disease is provided. Several aspects of the treatment of the disease, including an historical perspective, current approaches, and future research opportunities, are described. DATA SOURCES: Current medical literature, including abstracts presented at international meetings, is reviewed. References were identified through MEDLINE, Current Contents,
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14

Kaniga, Koné, Daniela M. Cirillo, Sven Hoffner, et al. "A Multilaboratory, Multicountry Study To Determine Bedaquiline MIC Quality Control Ranges for Phenotypic Drug Susceptibility Testing." Journal of Clinical Microbiology 54, no. 12 (2016): 2956–62. http://dx.doi.org/10.1128/jcm.01123-16.

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The aim of this study was to establish standardized drug susceptibility testing (DST) methodologies and reference MIC quality control (QC) ranges for bedaquiline, a diarylquinoline antimycobacterial, used in the treatment of adults with multidrug-resistant tuberculosis. Two tier-2 QC reproducibility studies of bedaquiline DST were conducted in eight laboratories using Clinical Laboratory and Standards Institute (CLSI) guidelines. Agar dilution and broth microdilution methods were evaluated.Mycobacterium tuberculosisH37Rv was used as the QC reference strain. Bedaquiline MIC frequency, mode, and
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15

Bergmann, John S., Geoffrey Fish, and Gail L. Woods. "Evaluation of the BBL MGIT (Mycobacterial Growth Indicator Tube) AST SIRE System for Antimycobacterial Susceptibility Testing of Mycobacterium tuberculosis to 4 Primary Antituberculous Drugs." Archives of Pathology & Laboratory Medicine 124, no. 1 (2000): 82–86. http://dx.doi.org/10.5858/2000-124-0082-eotbmm.

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Abstract Objective.—To evaluate the performance of the BBL MGIT (Mycobacterial Growth Indicator Tube) AST SIRE system for the antimycobacterial susceptibility testing of Mycobacterium tuberculosis to isoniazid (at a concentration equivalent to the lower concentration used for testing by the method of proportion), rifampin, ethambutol, and streptomycin. Design.—Thirty-one clinical isolates and 30 challenge strains provided by the Centers for Disease Control and Prevention (CDC) were tested by MGIT AST SIRE using 2 methods of inoculum preparation, and results were compared with those of the meth
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16

Srinivas, A. "Anti-microbial susceptibility pattern of spores used in Bacillus clausii suspension: an in vitro study." International Journal of Contemporary Pediatrics 7, no. 5 (2020): 980. http://dx.doi.org/10.18203/2349-3291.ijcp20201511.

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Background: Bacillus species have been used as probiotics as they have high stability to gastrointestinal conditions and impart health benefit on the host. Primarily used in their spore form the diversity of Bacillus species being used and their applications are remarkable. Here, we present the results of the antimicrobial susceptibility testing of the B. clausii spore suspension (Benegut®).Methods: Bacillus clausii spore suspension (Benegut®), used in oral bacteriotherapy was tested for the susceptibility to therapeutically useful antibiotics. Twelve commercially prepared, paper antibiotic di
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17

Alcaide, Fernando, Laura Calatayud, Miguel Santín, and Rogelio Martín. "Comparative In Vitro Activities of Linezolid, Telithromycin, Clarithromycin, Levofloxacin, Moxifloxacin, and Four Conventional Antimycobacterial Drugs against Mycobacterium kansasii." Antimicrobial Agents and Chemotherapy 48, no. 12 (2004): 4562–65. http://dx.doi.org/10.1128/aac.48.12.4562-4565.2004.

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ABSTRACT Mycobacterium kansasii is one of the most pathogenic and frequent nontuberculous mycobacteria isolated from humans. Patients with adverse drug reactions, resistant isolates, or suboptimal response require alternative treatment regimens. One hundred forty-eight consecutive clinical isolates of M. kansasii were tested for antimicrobial susceptibilities by the BACTEC 460 system (NCCLS) with two different inoculation protocols, one conventional and one alternative. In the alternative protocol, the inoculum 12B vial was incubated until the growth index was between 250 and 500. Four convent
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18

Lytvynenko, N. A., M. V. Pogrebna, Yu O. Senko, L. M. Protsyk, S. P. Korotchenko, and R. L. Liubevych. "Treatment of MDR-TB/HIV/CMV patients under individualized regimes of antimycobacterial therapy." Infusion & Chemotherapy, no. 4 (December 28, 2022): 52–58. http://dx.doi.org/10.32902/2663-0338-2022-4-52-58.

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BACKGROUND. Often in practice there are combinations of several diseases, or tuberculosis of the respiratory organs develops against the background of various comorbidities, including HIV.
 OBJECTIVE. To demonstrate best clinical practices for selecting the optimal individualized treatment regimen (ITR) in a patient with multidrug-resistant tuberculosis (MDR-TB) associated with HIV in the setting of severe immunosuppression and complicated by poor tolerability.
 MATERIALS AND METHODS. Presented clinical analysis of newly diagnosed generalized MDR-TB associated with HIV, treated for I
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19

Griffith, David. "Treatment of Mycobacterium avium Complex (MAC)." Seminars in Respiratory and Critical Care Medicine 39, no. 03 (2018): 351–61. http://dx.doi.org/10.1055/s-0038-1660472.

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Abstract Mycobacterium avium complex (MAC) is the most commonly isolated nontuberculous mycobacterial respiratory pathogen worldwide. MAC lung disease is manifested either by fibrocavitary radiographic changes similar to pulmonary tuberculosis or by bronchiectasis with nodular and reticulonodular radiographic changes. This latter form of MAC lung disease, termed “nodular bronchiectatic (NB) MAC lung disease” is the most common form of MAC lung disease in the United States. Treatment at the time of diagnosis is always indicated for fibrocavitary MAC lung disease because it is always progressive
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Marianelli, Cinzia, Angelo Leonori, Romana Stecco, and Carlo Giannantoni. "Detection of a Mixed-Strain Infection with Drug- and Multidrug-Resistant Mycobacterium avium Subspecies hominissuis in a Dog with Generalized Lymphadenomegaly." Antibiotics 14, no. 4 (2025): 416. https://doi.org/10.3390/antibiotics14040416.

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Background Members of the Mycobacterium avium complex (MAC) have been documented to cause severe and disseminated infections in dogs, although such cases are sporadically reported. In this study, a comprehensive account of a rare case of generalised lymphadenomegaly caused by a mixed-strain infection with drug- and multidrug-resistant Mycobacterium avium subspecies hominissuis (Mah) in a Maremma sheepdog is presented. Methods Laboratory investigations, as well as the monitoring of the clinical signs displayed by the animal, were conducted throughout the course of a two-year drug therapy (based
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21

Peloquin, Charles A., and Shaun E. Berning. "Infection Caused by Mycobacterium Tuberculosis." Annals of Pharmacotherapy 28, no. 1 (1994): 72–84. http://dx.doi.org/10.1177/106002809402800115.

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OBJECTIVE: To update readers on the clinical management of infections caused by Mycobacterium tuberculosis, to provide a general description of the organism, culture and susceptibility testing, and clinical manifestations of the disease, and to provide several aspects of the treatment of the disease, including historical perspective, current approaches, and research opportunities for the future. DATA SOURCES: The current medical literature, including abstracts presented at recent international meetings, is reviewed. References were identified through MEDLINE, MEDLARS II, Current Contents, and
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22

Sakhelashvili, M. I., O. P. Kostyk, O. I. Sakhelashvili–­Bil, Z. I. Piskur, and J. J. Didyk. "Peculiarities of the chemo­drug resistance of M. tuberculosis to anti­tuberculous medications among children and adolescents from multidrug­resistant tuberculous focies." Tuberculosis, Lung Diseases, HIV Infection, no. 2 (June 17, 2022): 5–11. http://dx.doi.org/10.30978/tb-2022-2-5.

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Objective — to study the peculiarities of the resistance of M. tuberculosis (MTB) to antimycobacterial drugs (AMBD) among children and adolescents living in multidrug-resistant tuber­culous focies.
 Materials and methods. 246 children were examined, 145 of them had drug-resistant tuberculosis (TB), 101 children — susceptible form of the specific process, and 102 adult patients who became the source of the disease. Microbiological study in children, adolescents and adults included: detection of MTB in sputum by smear microscopy, seeding on Levenstein—Jensen medium, typing of isolated MTB o
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Bala, Shukal, Kenneth L. Hastings, Kazem Kazempour, Shelly Inglis, and Walla L. Dempsey. "Inhibition of Tumor Necrosis Factor Alpha Alters Resistance to Mycobacterium avium Complex Infection in Mice." Antimicrobial Agents and Chemotherapy 42, no. 9 (1998): 2336–41. http://dx.doi.org/10.1128/aac.42.9.2336.

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ABSTRACT Increased production of tumor necrosis factor alpha (TNF-α) appears to play an important role in the progression of human immunodeficiency virus disease. One treatment strategy being explored is the use of TNF-α inhibitors. TNF-α also appears to be important in conferring resistance to infections, and the inhibition of this cytokine may exacerbate the emergence of opportunistic pathogens, such as Mycobacterium avium complex (MAC). The present study examines the possibility that inhibition of TNF-α will increase the progression of disease in mice infected with MAC. C57BL/6 beige (bg/bg
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24

Quenelle, Debra C., Gary A. Winchester, Jay K. Staas, Esther L. W. Barrow, and William W. Barrow. "Treatment of Tuberculosis Using a Combination of Sustained-Release Rifampin-Loaded Microspheres and Oral Dosing with Isoniazid." Antimicrobial Agents and Chemotherapy 45, no. 6 (2001): 1637–44. http://dx.doi.org/10.1128/aac.45.6.1637-1644.2001.

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ABSTRACT Previously, we reported on the use of rifampin-loaded microspheres to effectively treat Mycobacterium tuberculosis-infected macrophages and mice. Using similar biocompatible polymeric excipients of lactide and glycolide copolymers, we have increased the rifampin loading of small microsphere formulations (1 to 10 μm) by fourfold. Improved formulations were evaluated individually and in combination with oral regimens of isoniazid for the treatment ofMycobacterium tuberculosis H37Rv-infected mice. Groups (10 mice per group) consisted of mice that received (i) oral dosages of isoniazid (2
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25

Hendon-Dunn, Charlotte Louise, Kathryn Sarah Doris, Stephen Richard Thomas, et al. "A Flow Cytometry Method for Rapidly Assessing Mycobacterium tuberculosis Responses to Antibiotics with Different Modes of Action." Antimicrobial Agents and Chemotherapy 60, no. 7 (2016): 3869–83. http://dx.doi.org/10.1128/aac.02712-15.

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ABSTRACTCurrent methods for assessing the drug susceptibility ofMycobacterium tuberculosisare lengthy and do not capture information about viable organisms that are not immediately culturable under standard laboratory conditions as a result of antibiotic exposure. We have developed a rapid dual-fluorescence flow cytometry method using markers for cell viability and death. We show that the fluorescent marker calcein violet with an acetoxy-methyl ester group (CV-AM) can differentiate between populations ofM. tuberculosisgrowing at different rates, while Sytox green (SG) can differentiate between
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Kaniga, Koné, Daniela M. Cirillo, Sven Hoffner, et al. "A Multilaboratory, Multicountry Study To Determine MIC Quality Control Ranges for Phenotypic Drug Susceptibility Testing of Selected First-Line Antituberculosis Drugs, Second-Line Injectables, Fluoroquinolones, Clofazimine, and Linezolid." Journal of Clinical Microbiology 54, no. 12 (2016): 2963–68. http://dx.doi.org/10.1128/jcm.01138-16.

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Our objective was to establish reference MIC quality control (QC) ranges for drug susceptibility testing of antimycobacterials, including first-line agents, second-line injectables, fluoroquinolones, and World Health Organization category 5 drugs for multidrug-resistant tuberculosis using a 7H9 broth microdilution MIC method. A tier-2 reproducibility study was conducted in eight participating laboratories using Clinical Laboratory and Standards Institute (CLSI) guidelines. Three lots of custom-made frozen 96-well polystyrene microtiter plates were used and prepared with 2× prediluted drugs in
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Brown-Elliott, Barbara A., and Gail L. Woods. "Antimycobacterial Susceptibility Testing of Nontuberculous Mycobacteria." Journal of Clinical Microbiology 57, no. 10 (2019). http://dx.doi.org/10.1128/jcm.00834-19.

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ABSTRACT Recommendations for first-line and second-line drug testing and organism group, specific methodologies, and reporting recommendations have been addressed by the Clinical and Laboratory Standards Institute (CLSI) and are important in the selection of appropriate antimicrobial treatment regimens for nontuberculous mycobacteria (NTM) disease. This review also includes recent information on new antimicrobials proposed for the treatment of NTM but not yet addressed by the CLSI and molecular (gene sequencing) methods associated with the detection of antimicrobial resistance of two major the
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28

Keiff, François, Thibault J. W. Jacques dit Lapierre, Freddy A. Bernal, and Florian Kloss. "Design and synthesis of benzofuran‐ and naphthalene‐fused thiazinones as antimycobacterial agents." Archiv der Pharmazie, September 4, 2023. http://dx.doi.org/10.1002/ardp.202300356.

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AbstractBenzothiazinones (BTZs) have widely inspired medicinal chemistry and translational research due to their remarkable antitubercular potency and clinical potential. While most structure–activity relationship campaigns have largely focused on lateral chain modifications and substituents on the BTZ core, scaffold hopping strategies have been rarely investigated previously. In this work, we report the first example of ring expansion of the BTZ core toward benzofuran‐ and naphthalene‐fused thiazinones. In vitro testing showed micromolar activity for both compounds, and molecular docking simu
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Trivedi, Mahendra. "An Impact of Biofield treatment: Antimycobacterial Susceptibility Potential Using BACTEC 460/MGIT-TB System." OMICS International, July 27, 2015. https://doi.org/10.5281/zenodo.813388.

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The aim was to evaluate the impact of biofield treatment modality on mycobacterial strains in relation to antimycobacterials susceptibility. Mycobacterial sensitivity was analysed using 12 B BACTEC vials on the BACTEC 460 TB machine in 39 lab isolates (sputum samples) from stored stock cultures. Two American Type Culture Collection (ATCC) strains were also used to assess the minimum inhibitory concentration (MIC) of antimicrobials (Mycobacterium smegmatis 14468 and Mycobacterium tuberculosis 25177). Rifampicin, ethambutol and streptomycin in treated samples showed increased susceptibility as 3
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Khursheed, Nazia, Sunil Asif, Safia Bano, Maria Mushtaq Ali, and Fareeha Adnan. "Susceptibility pattern of Mycobacterium tuberculosis over a period of five years at Indus Hospital and Health Network, Karachi, Pakistan." Pakistan Journal of Medical Sciences 38, ICON-2022 (2021). http://dx.doi.org/10.12669/pjms.38.icon-2022.5778.

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Objective: To determine the susceptibility pattern and frequency of isolation of multidrug, pre-extensively drug and extensively drug resistant TB in a tertiary care hospital in Karachi, Pakistan.
 Method: A cross-sectional study was designed. Samples received in the lab were processed for growth and sensitivity testing of Mycobacterium tuberculosis. Isolation of MTB was done on Mycobacteria growth indicator tube (MGIT) followed by identification using MPT64. Samples were than evaluated for drug sensitivity against first and second-line antimycobacterial drugs. Statistical analysis was pe
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Kalsum, Sadaf, Blanka Andersson, Jyotirmoy Das, Thomas Schön, and Maria Lerm. "A high-throughput screening assay based on automated microscopy for monitoring antibiotic susceptibility of Mycobacterium tuberculosis phenotypes." BMC Microbiology 21, no. 1 (2021). http://dx.doi.org/10.1186/s12866-021-02212-3.

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Abstract Background Efficient high-throughput drug screening assays are necessary to enable the discovery of new anti-mycobacterial drugs. The purpose of our work was to develop and validate an assay based on live-cell imaging which can monitor the growth of two distinct phenotypes of Mycobacterium tuberculosis and to test their susceptibility to commonly used TB drugs. Results Both planktonic and cording phenotypes were successfully monitored as fluorescent objects using the live-cell imaging system IncuCyte S3, allowing collection of data describing distinct characteristics of aggregate size
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Zakhour, Johnny, Elio Bitar, Mariam Chalhoub, Saliba Wehbe, Souad Bou Harb, and Souha S. Kanj. "2583. Antimicrobial Resistance Profile of Mycobacterium simiae and Treatment Trends from a Tertiary Care Center in Lebanon." Open Forum Infectious Diseases 10, Supplement_2 (2023). http://dx.doi.org/10.1093/ofid/ofad500.2198.

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Abstract Background Mycobacterium simiae is a rare non-tuberculous mycobacterium (NTM) that is most identified in some Middle Eastern countries. It is unclear why this NTM is geographically restricted. The pathogen can either be a mere colonizer or cause significant morbidity. Patients with M. simiae infection require prolonged treatment with a combination of 3 antimicrobials. Drug resistance among M. simiae isolates can complicate the course of treatment. However, the correlation between in vitro resistance and clinical response is unknown. We aimed to report the susceptibility profile of M.
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Erber, Johanna, Simon Weidlich, Tristan Tschaikowsky, et al. "Successful bedaquiline-containing antimycobacterial treatment in post-traumatic skin and soft-tissue infection by Mycobacterium fortuitum complex: a case report." BMC Infectious Diseases 20, no. 1 (2020). http://dx.doi.org/10.1186/s12879-020-05075-7.

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Abstract Background Mycobacterium fortuitum complex is a group of rapidly growing nontuberculous mycobacteria (NTM) associated with skin and soft-tissue infections after surgery or trauma. Treatment of NTM is challenging, due to resistance to multiple antimycobacterial agents. Bedaquiline is a diarylquinoline that inhibits mycobacterial ATP-synthase. The drug has recently been approved for the treatment of multidrug-resistant tuberculosis and evidence of its in vitro efficacy against NTM, including Mycobacterium fortuitum complex, has been published. Case presentation A 20-year-old Caucasian w
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Park, Jiyun, Lee-Han Kim, Ju Mi Lee, et al. "In vitro and intracellular activities of novel thiopeptide derivatives against macrolide-susceptible and macrolide-resistant Mycobacterium avium complex." Microbiology Spectrum, August 18, 2023. http://dx.doi.org/10.1128/spectrum.01825-23.

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ABSTRACT Unsatisfactory outcomes following long-term multidrug treatment in patients with Mycobacterium avium complex (MAC) pulmonary disease have urged us to develop novel antibiotics. Thiopeptides, a class of peptide antibiotics derived from natural products, have potential as drug candidates that target bacterial ribosomes, but drug development has been hampered due to their extremely poor solubility. Here, we evaluated three new compounds (AJ-037, AJ-039, and AJ-206) derived from the thiopeptide micrococcin P2 with enhanced aqueous solubility; the derivatives were generated based on struct
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Binnebose, Andrea M., Adam S. Mullis, Shannon L. Haughney, Balaji Narasimhan, and Bryan H. Bellaire. "Nanotherapeutic delivery of antibiotic cocktail enhances intra-macrophage killing of Mycobacterium marinum." Frontiers in Antibiotics 2 (July 17, 2023). http://dx.doi.org/10.3389/frabi.2023.1162941.

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Mycobacterium marinum is a waterborne pathogen responsible for tuberculosis-like infections in cold-blooded animals and is an opportunistic pathogen in humans. M. marinum is the closest genetic relative of the Mycobacterium tuberculosis complex and is a reliable surrogate for drug susceptibility testing. We synthesized and evaluated two nanoparticle (NP) formulations for compatibility with rifampicin, isoniazid, pyrazinamide, and ethambutol (PIRE), the front-line antimycobacterial drugs used in combination against active tuberculosis infections. Improved in vitro antimicrobial activity was obs
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Shirley, Debbie-Ann, Paola Maurtua-Neumann, Lawrence Shoemaker, Kathryn DeSear та Khalid M. Dousa. "Case report of peritoneal dialysis-associated peritonitis caused by Mycobacterium abscessus in a child, successfully treated with dual β-lactam combination therapy". ASM Case Reports, 16 липня 2025. https://doi.org/10.1128/asmcr.00056-25.

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ABSTRACT Background Peritoneal dialysis-associated peritonitis caused by Mycobacterium abscessus is a rare and difficult-to-treat infection that frequently results in peritoneal dialysis failure. Since M. abscessus is intrinsically resistant to many antibiotics, therapeutic decisions are challenging. While data are limited, a prolonged course of antibiotics with at least two or three agents is recommended, guided by susceptibility testing. Many regimens use amikacin, which can worsen renal function and cause deafness. There is limited safety and efficacy data on newer antimycobacterial medicat
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Molina-Torres, Carmen Amelia, Oscar Noé Flores-Castillo, Irma Edith Carranza-Torres, et al. "Ex vivo infection of murine precision-cut lung tissue slices with Mycobacterium abscessus: a model to study antimycobacterial agents." Annals of Clinical Microbiology and Antimicrobials 19, no. 1 (2020). http://dx.doi.org/10.1186/s12941-020-00399-3.

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Abstract Background Multidrug-resistant infections due to Mycobacterium abscessus often require complex and prolonged regimens for treatment. Here, we report the evaluation of a new ex vivo antimicrobial susceptibility testing model using organotypic cultures of murine precision-cut lung slices, an experimental model in which metabolic activity, and all the usual cell types of the organ are found while the tissue architecture and the interactions between the different cells are maintained. Methods Precision cut lung slices (PCLS) were prepared from the lungs of wild type BALB/c mice using the
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Sao Emani, Carine, and Norbert Reiling. "Spermine enhances the activity of anti-tuberculosis drugs." Microbiology Spectrum, December 14, 2023. http://dx.doi.org/10.1128/spectrum.03568-23.

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ABSTRACT The discovery of molecules that could shorten the treatment period of tuberculosis (TB) holds the promise of improving the current regimen. Polyamines are organic polycationic alkylamines found in millimolar concentrations in all living cells. Spermine (Spm) is a polyamine that was shown (more than 70 years ago) to be toxic to Mycobacterium tuberculosis (M.tb). In this study, we used various biochemical assays to assess the mechanism of action of Spm. Furthermore, using various drug susceptibility testing methods, we investigated the ability of Spm to enhance the activity of first-lin
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Sarathy, Jickky Palmae, Priya Ragunathan, Joon Shin та ін. "TBAJ-876 Retains Bedaquiline’s Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase". Antimicrobial Agents and Chemotherapy 63, № 10 (2019). http://dx.doi.org/10.1128/aac.01191-19.

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ABSTRACT The antituberculosis drug bedaquiline (BDQ) inhibits Mycobacterium tuberculosis F-ATP synthase by interfering with two subunits. Drug binding to the c subunit stalls the rotation of the c ring, while binding to the ε subunit blocks coupling of c ring rotation to ATP synthesis at the catalytic α3:β3 headpiece. BDQ is used for the treatment of drug-resistant tuberculosis. However, the drug is highly lipophilic, displays a long terminal half-life, and has a cardiotoxicity liability by causing QT interval prolongation. Recent medicinal chemistry campaigns have resulted in the discovery of
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Mark Gill, Christian, Robin R. Chamberland, and Getahun Abate. "P-763. Assessment of the in vitro potency of anti-mycobacterial agents against clinical Mycobacterium avium complex (MAC) pulmonary isolates: implications of intravenous and inhaled amikacin breakpoint reporting." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.958.

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Abstract Background MAC pulmonary disease is associated with significant morbidity and requires multi-drug treatment for extended periods. The novel dosage form amikacin liposome inhalation suspension (ALIS) represents a much-needed treatment option and is noted to have success at MICs of ≤64mg/L, higher than the intravenous (IV) amikacin (AMK) breakpoint (≤16 mg/L) due to optimized pulmonary exposure. Herein, we assessed the in vitro potency of AMK utilizing both ALIS and IV breakpoints as well as other standard antimycobacterial agents. Methods MAC isolates obtained from sputum, bronchoalveo
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Ogwang, Martin O., Mabel Imbuga, Caroline Ngugi, Lucy Mutharia, Gabriel Magoma, and Lamec Diero. "Distribution patterns of drug resistance Mycobacterium tuberculosis among HIV negative and positive tuberculosis patients in Western Kenya." BMC Infectious Diseases 21, no. 1 (2021). http://dx.doi.org/10.1186/s12879-021-06887-x.

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Abstract Introduction Globally anti-tuberculosis drug resistance is one of the major challenges affecting control and prevention of tuberculosis. Kenya is ranked among 30 high burden TB countries globally. However, there is scanty information on second line antituberculosis drug resistance among tuberculosis patients. Therefore, this study aimed at determining Mycobacterium tuberculosis drug resistant strain distribution pattern in 10 counties of Western Kenya among HIV positive and negative patients. Method A cross-sectional study was conducted in Western Kenya, which comprises 10 counties. A
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