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Artykuły w czasopismach na temat „ASIC”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Dusenkova, Svetlana, Fei Ru, Lenka Surdenikova, et al. "The expression profile of acid-sensing ion channel (ASIC) subunits ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 in the esophageal vagal afferent nerve subtypes." American Journal of Physiology-Gastrointestinal and Liver Physiology 307, no. 9 (2014): G922—G930. http://dx.doi.org/10.1152/ajpgi.00129.2014.

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Acid-sensing ion channels (ASICs) have been implicated in esophageal acid sensing and mechanotransduction. However, insufficient knowledge of ASIC subunit expression profile in esophageal afferent nerves hampers the understanding of their role. This knowledge is essential because ASIC subunits form heteromultimeric channels with distinct functional properties. We hypothesized that the esophageal putative nociceptive C-fiber nerves (transient receptor potential vanilloid 1, TRPV1-positive) express multiple ASIC subunits and that the ASIC expression profile differs between the nodose TRPV1-posit

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2

Martínez-Barbero, Graciela, Yolanda García-Mesa, Ramón Cobo, et al. "Acid-Sensing Ion Channels’ Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body." International Journal of Molecular Sciences 24, no. 24 (2023): 17161. http://dx.doi.org/10.3390/ijms242417161.

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The carotid body is a major peripheral chemoreceptor that senses changes in arterial blood oxygen, carbon dioxide, and pH, which is important for the regulation of breathing and cardiovascular function. The mechanisms by which the carotid body senses O2 and CO2 are well known; conversely, the mechanisms by which it senses pH variations are almost unknown. Here, we used immunohistochemistry to investigate how the human carotid body contributes to the detection of acidosis, analyzing whether it expresses acid-sensing ion channels (ASICs) and determining whether these channels are in the chemosen

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3

Storozhuk, Maksim, Andrii Cherninskyi, Oleksandr Maximyuk, Dmytro Isaev, and Oleg Krishtal. "Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain." Current Neuropharmacology 19, no. 9 (2021): 1570–89. http://dx.doi.org/10.2174/1570159x19666210125151824.

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Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons and predominantly expressed in the nervous system. ASICs act as pH sensors leading to neuronal excitation. At least eight different ASIC subunits (including ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4, ASIC5) are encoded by five genes (ASIC1-ASIC5). Functional ASICs assembled in the plasma membrane are homo- or heteromeric trimers. ASIC1a-containing trimers are of particular interest as, in addition to sodium ions, they also conduct calcium ions and thus can trigger or regulate multiple cellular processes. A

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4

Jernigan, Nikki L., Michael L. Paffett, Benjimen R. Walker, and Thomas C. Resta. "ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca2+ entry." American Journal of Physiology-Lung Cellular and Molecular Physiology 297, no. 2 (2009): L271—L285. http://dx.doi.org/10.1152/ajplung.00020.2009.

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Acid-sensing ion channels (ASIC) are voltage-insensitive, cationic channels that have recently been identified in vascular smooth muscle (VSM). It is possible that ASIC contribute to vascular reactivity via Na+ and Ca2+ conductance; however, their function in VSM is largely unknown. In pulmonary VSM, store-operated Ca2+ entry (SOCE) plays a significant role in vasoregulatory mechanisms such as hypoxic pulmonary vasoconstriction and receptor-mediated arterial constriction. Therefore, we hypothesized that ASIC contribute to SOCE in pulmonary VSM. We examined SOCE resulting from depletion of intr

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5

Hu, Zhuang-Li, Chao Huang, Hui Fu, et al. "Disruption of PICK1 attenuates the function of ASICs and PKC regulation of ASICs." American Journal of Physiology-Cell Physiology 299, no. 6 (2010): C1355—C1362. http://dx.doi.org/10.1152/ajpcell.00569.2009.

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Acid-sensing ion channels (ASICs) extensively exist in both central and peripheral neuronal systems and contribute to many physiological and pathological processes. The protein that interacts with C kinase 1 (PICK1) was cloned as one of the proteins interacting with protein kinase C (PKC) and colocalized with ASIC1 and ASIC2. Here, we used PICK1 knockout (PICK1-KO) C57/BL6 mice together with the whole cell patch clamp, calcium imaging, RT-PCR, Western blot, and immunocytochemistry techniques to explore the possible change in ASICs and the regulatory effects of PKC on ASICs. The results showed

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6

Dymowska, Agnieszka K., Aaron G. Schultz, Salvatore D. Blair, Danuta Chamot, and Greg G. Goss. "Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss." American Journal of Physiology-Cell Physiology 307, no. 3 (2014): C255—C265. http://dx.doi.org/10.1152/ajpcell.00398.2013.

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A role for acid-sensing ion channels (ASICs) to serve as epithelial channels for Na+ uptake by the gill of freshwater rainbow trout was investigated. We found that the ASIC inhibitors 4′,6-diamidino-2-phenylindole and diminazene decreased Na+ uptake in adult rainbow trout in a dose-dependent manner, with IC50 values of 0.12 and 0.96 μM, respectively. Furthermore, we cloned the trout ASIC1 and ASIC4 homologs and demonstrated that they are expressed differentially in the tissues of the rainbow trout, including gills and isolated mitochondrion-rich cells. Immunohistochemical analysis using custom

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7

Xie, Jinghui, Margaret P. Price, John A. Wemmie, Candice C. Askwith, and Michael J. Welsh. "ASIC3 and ASIC1 Mediate FMRFamide-Related Peptide Enhancement of H+-Gated Currents in Cultured Dorsal Root Ganglion Neurons." Journal of Neurophysiology 89, no. 5 (2003): 2459–65. http://dx.doi.org/10.1152/jn.00707.2002.

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The acid-sensing ion channels (ASICs) form cation channels that are transiently activated by extracellular protons. They are expressed in dorsal root ganglia (DRG) neurons and in the periphery where they play a function in nociception and mechanosensation. Previous studies showed that FMRFamide and related peptides potentiate H+-gated currents. To better understand this potentiation, we examined the effect of FMRFamide-related peptides on DRG neurons from wild-type mice and animals missing individual ASIC subunits. We found that FMRFamide and FRRFamide potentiated H+-gated currents of wild-typ

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8

Corrow, Kimberly, Beatrice M. Girard, and Margaret A. Vizzard. "Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis." American Journal of Physiology-Renal Physiology 298, no. 5 (2010): F1130—F1139. http://dx.doi.org/10.1152/ajprenal.00618.2009.

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The expression of acid-sensing ion channel (ASIC) isoforms, ASIC1, ASIC2a, and ASIC3, was examined in the urinary bladder after cyclophosphamide (CYP)-induced cystitis of varying duration (4 h, 48 h, and chronic). Immunohistochemical, Western blot, and quantitative PCR approaches were used to evaluate channel expression and effects of CYP-induced cystitis in whole urinary bladder and split-bladder preparations from control (no inflammation) and CYP-treated rats. Quantitative PCR demonstrated significant ( P ≤ 0.01) increases in ASIC2a and ASIC3 transcripts with CYP-induced cystitis (48 h and c

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9

Jiang, Qian, Felix Yang, Amber Sun, et al. "ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide." Biomolecules 15, no. 4 (2025): 479. https://doi.org/10.3390/biom15040479.

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Cyanide (CN) is a potent, fast-acting toxicant that impacts endogenous biomolecules in the nervous system, including acid-sensing ion channels (ASICs), which play a vital role in various neurological and psychological conditions. Here, we demonstrate that CN rapidly potentiates ASIC currents in cultured mouse cortical neurons in a dose-dependent manner while causing a leftward shift in the pH dose–response curve. Notably, this potentiation was unaffected by a 30-min CN treatment or the presence of ATP in the recording pipette. Further investigations into the role of zinc revealed that TPEN, a

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10

Lee, Ching-Yu, Tsung-Jen Huang, Meng-Huang Wu, Yen-Yao Li, and Kuan-Der Lee. "High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures." BioMed Research International 2019 (August 19, 2019): 1–10. http://dx.doi.org/10.1155/2019/4714279.

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Little is known about the function of acid-sensing ion channels (ASICs) in bone cells or osteoporotic vertebral fractures (OVF). This study delineated ASICs expression in adult human bone marrow-mesenchymal stem cells- (BM-MSC-) derived osteoblasts and in OVF bone cells. Adult BM-MSC-derived osteoblasts were isolated and cultured in different pH values. Osteogenic markers as alkaline phosphatase (ALP), osteopontin (OPN), and osteocalcin (OC) mRNA were assessed. Western blots method was applied to analyze ASICs protein expression in different pH values. Amiloride was added into the osteogenic m

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11

Kusama, Nobuyoshi, Mamta Gautam, Anne Marie S. Harding, Peter M. Snyder, and Christopher J. Benson. "Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition." American Journal of Physiology-Cell Physiology 304, no. 1 (2013): C89—C101. http://dx.doi.org/10.1152/ajpcell.00216.2012.

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Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl−-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We previously found that anions modulate ASIC1a gating via these sites. Here we investigated the effect of anion substitution on native ASICs in rat sensory neurons and heterologously expressed ASIC2a and ASIC3 channels by whole cell patch clamp. Similar to ASIC1a, anions modulated the kinetics of desensitization of other ASIC channels. However, unlike ASIC1a, anions also modul

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12

Brockway, L. M., Z. H. Zhou, J. K. Bubien, B. Jovov, D. J. Benos, and K. T. Keyser. "Rabbit retinal neurons and glia express a variety of ENaC/DEG subunits." American Journal of Physiology-Cell Physiology 283, no. 1 (2002): C126—C134. http://dx.doi.org/10.1152/ajpcell.00457.2001.

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Some members of the epithelial Na+ channel/degenerin (ENaC/DEG) family of ion channels have been detected in mammalian brain. Therefore, we examined the RNA and protein expression of these channels in another part of the central nervous system, the rabbit retina. We next sought to demonstrate physiological evidence for an amiloride-sensitive current in Müller glia, which, on the basis of a previous study, are thought to express α-ENaC (Golestaneh N, de Kozak Y, Klein C, and Mirshahi M. Glia 33: 160–168, 2001). RT-PCR of retinal RNA revealed the presence of α-, β-, γ-, and δ-ENaC as well as aci

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13

Platonov, Maksym, Oleksandr Maximyuk, Alexey Rayevsky, et al. "4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors." International Journal of Molecular Sciences 25, no. 7 (2024): 3584. http://dx.doi.org/10.3390/ijms25073584.

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Acid-sensing ion channels (ASICs) play a key role in the perception and response to extracellular acidification changes. These proton-gated cation channels are critical for neuronal functions, like learning and memory, fear, mechanosensation and internal adjustments like synaptic plasticity. Moreover, they play a key role in neuronal degeneration, ischemic neuronal injury, seizure termination, pain-sensing, etc. Functional ASICs are homo or heterotrimers formed with (ASIC1–ASIC3) homologous subunits. ASIC1a, a major ASIC isoform in the central nervous system (CNS), possesses an acidic pocket i

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14

Cegielski, Victoria, Rohan Chakrabarty, Shinghua Ding, Michael J. Wacker, Paula Monaghan-Nichols, and Xiang-Ping Chu. "Acid-Sensing Ion Channels in Glial Cells." Membranes 12, no. 2 (2022): 119. http://dx.doi.org/10.3390/membranes12020119.

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Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells. ASIC1a is expressed in astrocytes and might contribute to synaptic transmission and long-term potentiation. In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in micro

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15

Ruan, Nina, Jacob Tribble, Andrew M. Peterson, Qian Jiang, John Q. Wang, and Xiang-Ping Chu. "Acid-Sensing Ion Channels and Mechanosensation." International Journal of Molecular Sciences 22, no. 9 (2021): 4810. http://dx.doi.org/10.3390/ijms22094810.

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Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear conditioning. These channels have also been implicated in multiple disease conditions, including ischemic brain injury, multiple sclerosis, Alzheimer’s disease, and drug addiction. Recent research has illustrated the involvement of ASICs in mech

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16

Sun, Hua-Wei, Xiang-Ping Chu, Roger P. Simon, Zhi-Gang Xiong, and Tian-Dong Leng. "Inhibition of Acid-Sensing Ion Channels by KB-R7943, a Reverse Na+/Ca2+ Exchanger Inhibitor." Biomolecules 13, no. 3 (2023): 507. http://dx.doi.org/10.3390/biom13030507.

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KB-R7943, an isothiourea derivative, is widely used as a pharmacological inhibitor of reverse sodium–calcium exchanger (NCX). It has been shown to have neuroprotective and analgesic effects in animal models; however, the detailed molecular mechanisms remain elusive. In the current study, we investigated whether KB-R7943 modulates acid-sensing ion channels (ASICs), a group of proton-gated cation channels implicated in the pathophysiology of various neurological disorders, using the whole-cell patch clamp techniques. Our data show that KB-R7943 irreversibly inhibits homomeric ASIC1a channels het

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17

Evlanenkov, Konstantin K., Maxim V. Nikolaev, Natalia N. Potapieva, Konstantin V. Bolshakov, and Denis B. Tikhonov. "Probing the Proton-Gated ASIC Channels Using Tetraalkylammonium Ions." Biomolecules 13, no. 11 (2023): 1631. http://dx.doi.org/10.3390/biom13111631.

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The action of tetraalkylammonium ions, from tetrametylammonium (TMA) to tetrapentylammonium (TPtA), on the recombinant and native acid-sensing ion channels (ASICs) was studied using the patch-clamp approach. The responses of ASIC1a, ASIC2a, and native heteromeric ASICs were inhibited by TPtA. The peak currents through ASIC3 were unaffected, whereas the steady-state currents were significantly potentiated. This effect was characterized by an EC50 value of 1.22 ± 0.12 mM and a maximal effect of 3.2 ± 0.5. The effects of TPtA were voltage-independent but significantly decreased under conditions o

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18

Johnson, Martha B., KunLin Jin, Manabu Minami, Dexi Chen, and Roger P. Simon. "Global Ischemia Induces Expression of Acid-Sensing Ion Channel 2a in Rat Brain." Journal of Cerebral Blood Flow & Metabolism 21, no. 6 (2001): 734–40. http://dx.doi.org/10.1097/00004647-200106000-00011.

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Acid-sensing ion channels (ASICs) are ligand-gated cation channels that respond to acidic stimuli. They are expressed throughout the mammalian nervous system. In the peripheral nervous system, ASICs act as nociceptors, responding to the tissue acidosis that accompanies ischemic and inflammatory conditions. The function of ASICs in the central nervous system is not known. In this article, the authors present evidence that transient global ischemia induces ASIC 2a protein expression in neurons that survive ischemia. Western blot analysis with an anti-ASIC 2a antibody revealed up-regulation of an

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19

Cho, Jun-Hyeong, and Candice C. Askwith. "Presynaptic Release Probability Is Increased in Hippocampal Neurons From ASIC1 Knockout Mice." Journal of Neurophysiology 99, no. 2 (2008): 426–41. http://dx.doi.org/10.1152/jn.00940.2007.

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Acid-sensing ion channels (ASICs) are H+-gated channels that produce transient cation currents in response to extracellular acid. ASICs are expressed in neurons throughout the brain, and ASIC1 knockout mice show behavioral impairments in learning and memory. The role of ASICs in synaptic transmission, however, is not thoroughly understood. We analyzed the involvement of ASICs in synaptic transmission using microisland cultures of hippocampal neurons from wild-type and ASIC knockout mice. There was no significant difference in single action potential (AP)–evoked excitatory postsynaptic currents

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20

Sherwood, Thomas W., Erin N. Frey, and Candice C. Askwith. "Structure and activity of the acid-sensing ion channels." American Journal of Physiology-Cell Physiology 303, no. 7 (2012): C699—C710. http://dx.doi.org/10.1152/ajpcell.00188.2012.

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The acid-sensing ion channels (ASICs) are a family of proton-sensing channels expressed throughout the nervous system. Their activity is linked to a variety of complex behaviors including fear, anxiety, pain, depression, learning, and memory. ASICs have also been implicated in neuronal degeneration accompanying ischemia and multiple sclerosis. As a whole, ASICs represent novel therapeutic targets for several clinically important disorders. An understanding of the correlation between ASIC structure and function will help to elucidate their mechanism of action and identify potential therapeutics

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21

Blanchard, Maxime G., and Stephan Kellenberger. "Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity." Pflugers Archiv : European Journal of Physiology 461, no. 1 (2010): 123–39. https://doi.org/10.1007/s00424-010-0884-3.

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Acid-sensing ion channels (ASICs) are neuronal H(+)-gated cation channels, and the transient receptor potential vanilloid 1 channel (TRPV1) is a multimodal cation channel activated by low pH, noxious heat, capsaicin, and voltage. ASICs and TRPV1 are present in sensory neurons. It has been shown that raising the temperature increases TRPV1 and decreases ASIC H(+)-gated current amplitudes. To understand the underlying mechanisms, we have analyzed ASIC and TRPV1 function in a recombinant expression system and in dorsal root ganglion (DRG) neurons at room and physiological temperature. We show tha

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22

Anubhav Mangla. "The Transformative Impact of ASICs across Industries: A Technical Analysis." International Journal of Scientific Research in Computer Science, Engineering and Information Technology 11, no. 1 (2025): 1791–99. https://doi.org/10.32628/cseit251112165.

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Application-Specific Integrated Circuits (ASICs) have emerged as a transformative technology in the semiconductor industry, revolutionizing various sectors, including healthcare, retail, agriculture, and computing. This comprehensive article explores the technical architecture, industry-specific implementations, challenges, and future directions of ASIC technology. The article examines the evolution of ASIC design methodologies and their impact on performance optimization, power efficiency, and manufacturing processes. It further investigates the integration of artificial intelligence in desig

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23

Vukicevic, Marija, and Stephan Kellenberger. "Modulatory effects of acid-sensing ion channels on action potential generation in hippocampal neurons." American Journal of Physiology-Cell Physiology 287, no. 3 (2004): C682—C690. http://dx.doi.org/10.1152/ajpcell.00127.2004.

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Extracellular acidification has been shown to generate action potentials (APs) in several types of neurons. In this study, we investigated the role of acid-sensing ion channels (ASICs) in acid-induced AP generation in brain neurons. ASICs are neuronal Na+ channels that belong to the epithelial Na+ channel/degenerin family and are transiently activated by a rapid drop in extracellular pH. We compared the pharmacological and biophysical properties of acid-induced AP generation with those of ASIC currents in cultured hippocampal neurons. Our results show that acid-induced AP generation in these n

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24

Liu, X., L. He, B. Dinger, and S. J. Fidone. "Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity." American Journal of Physiology-Lung Cellular and Molecular Physiology 301, no. 6 (2011): L985—L992. http://dx.doi.org/10.1152/ajplung.00132.2011.

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Previously we demonstrated that chronic hypoxia (CH) induces an inflammatory condition characterized by immune cell invasion and increased expression of inflammatory cytokines in rat carotid body. It is well established that chronic inflammatory pain induces the expression of acid-sensitive ion channels (ASIC) in primary sensory neurons, where they contribute to hyperalgesia and allodynia. The present study examines the effect of CH on ASIC expression in petrosal ganglion (PG), which contains chemoafferent neurons that innervate oxygen-sensitive type I cells in the carotid body. Five isoforms

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25

Sun, Amber W., Michelle H. Wu, Madhumathi Vijayalingam, Michael J. Wacker, and Xiang-Ping Chu. "The Role of Zinc in Modulating Acid-Sensing Ion Channel Function." Biomolecules 13, no. 2 (2023): 229. http://dx.doi.org/10.3390/biom13020229.

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Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels widely expressed throughout the central and peripheral nervous systems. They are involved in synaptic plasticity, learning/memory, fear conditioning and pain. Zinc, an important trace metal in the body, contributes to numerous physiological functions, with neurotransmission being of note. Zinc has been implicated in the modulation of ASICs by binding to specific sites on these channels and exerting either stimulatory or inhibitory effects depending on the ASIC subtype. ASICs have been linked to several neur

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Jiang, N., K. K. Rau, R. D. Johnson, and B. Y. Cooper. "Proton Sensitivity Ca2+ Permeability and Molecular Basis of Acid-Sensing Ion Channels Expressed in Glabrous and Hairy Skin Afferents." Journal of Neurophysiology 95, no. 4 (2006): 2466–78. http://dx.doi.org/10.1152/jn.00861.2005.

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We contrasted the physiology and peripheral targets of subclassified nociceptive and nonnociceptive afferents that express acid-sensing ion channel (ASIC)–like currents. The threshold for current activation was similar in eight distinct cell subclasses regardless of functional modality (pH 6.8). When potency was determined from concentration–response curves, nonnociceptors exhibited currents with significantly greater potency than that of all but one class of nociceptors (pH50 = 6.54 and 6.75 vs. 6.20–6.34). In nonnociceptive cells, acid transduction was also confined to a very narrow range (0

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Gladkikh, Irina N., Anna A. Klimovich, Rimma S. Kalina, et al. "Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica." Toxins 15, no. 5 (2023): 341. http://dx.doi.org/10.3390/toxins15050341.

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Acid-sensing ion channels (ASICs) have been known as sensors of a local pH change within both physiological and pathological conditions. ASIC-targeting peptide toxins could be potent molecular tools for ASIC-manipulating in vitro, and for pathology treatment in animal test studies. Two sea anemone toxins, native Hmg 1b-2 and recombinant Hmg 1b-4, both related to APETx-like peptides, inhibited the transient current component of human ASIC3-Δ20 expressed in Xenopus laevis oocytes, but only Hmg 1b-2 inhibited the rat ASIC3 transient current. The Hmg 1b-4 action on rASIC3 as a potentiator was conf

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Orita, T., M. Uenomachi, K. Shimazoe, and H. Ikeda. "Time and Energy Resolving Time-over-Threshold ASIC for MPPC module in TOF-PET system (ToT-ASIC2)." Journal of Instrumentation 18, no. 09 (2023): P09033. http://dx.doi.org/10.1088/1748-0221/18/09/p09033.

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Abstract ToT-ASIC2 is a new custom front-end application specific integrated circuit (ASIC) to readout silicon photomultiplier (SiPM) and multi-pixel photon counter (MPPC) for time-of-flight positron emission tomography (ToF-PET). ToT-ASIC2 is a 64-channel ASIC fabricated using a commercial 0.25 μm CMOS process. Each channel has an input-current buffer that sends signals to the SLOW and FAST paths, which are used for incident radiation energy and timing information, respectively. Time-over-Threshold (ToT) signals from these paths are combined into one ToT signal to be output outside the ASIC.

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Magaki, Ikuo, Moein Khazraee, Luis Vega Gutierrez, and Michael Bedford Taylor. "ASIC clouds." ACM SIGARCH Computer Architecture News 44, no. 3 (2016): 178–90. http://dx.doi.org/10.1145/3007787.3001156.

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Nicholson, Craig. "ASIC mind." Nature Reviews Neuroscience 9, no. 1 (2008): 6. http://dx.doi.org/10.1038/nrn2302.

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Flynn, M. J., and R. I. Winner. "ASIC microprocessors." ACM SIGMICRO Newsletter 20, no. 3 (1989): 237–43. http://dx.doi.org/10.1145/75395.75425.

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Taylor, Michael Bedford, Luis Vega, Moein Khazraee, Ikuo Magaki, Scott Davidson, and Dustin Richmond. "ASIC clouds." Communications of the ACM 63, no. 7 (2020): 103–9. http://dx.doi.org/10.1145/3399734.

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Zhang, Ping, та Cecilia M. Canessa. "Single Channel Properties of Rat Acid–sensitive Ion Channel-1α, -2a, and -3 Expressed in Xenopus Oocytes". Journal of General Physiology 120, № 4 (2002): 553–66. http://dx.doi.org/10.1085/jgp.20028574.

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The mammalian nervous system expresses proton-gated ion channels known as acid-sensing ion channels (ASICs). Depending on their location and specialization some neurons express more than one type of ASIC where they may form homo- or heteromeric channels. Macroscopic characteristics of the ASIC currents have been described, but little is known at the single channel level. Here, we have examined the properties of unitary currents of homomeric rat ASIC1α, ASIC2a, and ASIC3 expressed in Xenopus oocytes with the patch clamp technique. We describe and characterize properties unique to each of these

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Moroń, Jakub, Mirosław Firlej, Tomasz Fiutowski, Marek Idzik, and Krzysztof Świentek. "FLAXE, a SoC readout ASIC for electromagnetic calorimeter at LUXE experiment." Journal of Instrumentation 20, no. 01 (2025): C01026. https://doi.org/10.1088/1748-0221/20/01/c01026.

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Abstract The design and qualification results of a System on Chip (SoC) Application-Specific Integrated Circuit (ASIC), called FLAXE, fabricated in 130 nm CMOS technology are presented. FLAXE is a readout ASIC designed for ECAL-p, a compact electromagnetic calorimeter being a part of a detector system for Laser Und XFEL Experiment (LUXE) proposed at DESY, Hamburg, as an extension to the European X-ray Free Electron Laser (XFEL) facility. ECAL-p is a sampling calorimeter with a very compact design targeting small Molière radius, comprising 16 (up to 20) layers composed of 3.5 mm (1 X0) thick tu

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Verkest, Clément, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, and Anne Baron. "Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects." Toxins 14, no. 10 (2022): 709. http://dx.doi.org/10.3390/toxins14100709.

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Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form functional channels with highly pH-dependent gating properties. This review provides an update on the pharmacological profiles of animal peptide toxins targeting ASICs, including PcTx1 from tarantula and related spider toxins, APETx2 and APETx-like peptides from sea anemone, and mambalgin from snake, as well as the dimeric protein snake toxin MitTx

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Kotitsa, Rafaella Eleni. "Initial performance assessment and calibration techniques of the production monolithic silicon pixel detector ASIC for the detection of electromagnetic showers of TeV energy in the FASER experiment at the LHC." Journal of Instrumentation 20, no. 01 (2025): C01042. https://doi.org/10.1088/1748-0221/20/01/c01042.

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Abstract The FASER experiment at the LHC aims to detect new, long-lived fundamental particles. A tungsten-silicon (W-Si) preshower detector is being developed to enhance the experiment's ability to distinguish between closely spaced photon pairs with energies on the order of TeV and separations as small as 200 µm. This detector will use a monolithic silicon pixel sensor fabricated with 130 nm SiGe BiCMOS technology. Initial tests were conducted on the production ASIC, after evaluating the performance of the preproduction ASIC. The first tests on the production ASIC indicate that the essential

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Ievglevskyi, O., D. Isaev, O. Netsyk, et al. "Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1700 (2016): 20150431. http://dx.doi.org/10.1098/rstb.2015.0431.

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Acid-sensing ion channels (ASICs) play an important role in numerous functions in the central and peripheral nervous systems ranging from memory and emotions to pain. The data correspond to a recent notion that each neuron and many glial cells of the mammalian brain express at least one member of the ASIC family. However, the mechanisms underlying the involvement of ASICs in neuronal activity are poorly understood. However, there are two exceptions, namely, the straightforward role of ASICs in proton-based synaptic transmission in certain brain areas and the role of the Ca 2+ -permeable ASIC1a

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Patterson, EB, PG Holmes, and D. Morley. "Microprocessor/ASIC to total ASIC design for cycloconverter drives." Microprocessors and Microsystems 14, no. 4 (1990): 219–26. http://dx.doi.org/10.1016/0141-9331(90)90081-6.

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Grifoni, Samira C., Susan E. McKey, and Heather A. Drummond. "Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 5 (2008): H2022—H2030. http://dx.doi.org/10.1152/ajpheart.01271.2007.

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Recent studies suggest members of the degenerin (DEG)/epithelial Na+channel (ENaC)/acid-sensing ion channel (ASIC) protein family play an important role in vascular smooth muscle cell (VSMC) migration. In a previous investigation, we found suppression of a certain DEG/ENaC/ASIC member, ASIC2, increased VSMC chemotactic migration, raising the possibility that ASIC2 may play an inhibitory role. Because ASIC2 protein was retained in the cytoplasm, we reasoned increasing surface expression of ASIC2 might unmask the inhibitory role of ASIC2 in VSMC migration so we could test the hypothesis that ASI

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40

Martin, Douglas, Samuel Beilin, Brett Hamilton, Darin York, Philip Baker, and Wai-Yat Leung. "Application of Advanced Back-Side Optical Techniques in ASICs." Microscopy Today 21, no. 3 (2013): 30–35. http://dx.doi.org/10.1017/s1551929513000540.

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Failure analysis is important in determining root cause for appropriate corrective action. In order to perform failure analysis of microelectronic application-specific integrated circuits (ASICs) delidding the device is often required. However, determining root cause from the front side is not always possible due to shadowing effects caused by the ASIC metal interconnects. Therefore, back-side polishing is used to reveal an unobstructed view of the ASIC silicon transistors. This paper details how back-side polishing in conjunction with laser-scanned imaging (LSI), laser voltage imaging (LVI),

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Holmes, Jim, A. Matthew Francis, Ian Getreu, and Michael Glover. "A Unified ASIC and LTCC Module Design Kit for High-Temperature High-Density Circuits." Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT) 2016, CICMT (2016): 000169–72. http://dx.doi.org/10.4071/2016cicmt-wp43.

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Abstract State of the art high temperature ASIC design requires the complement of high temperature modules and circuit boards. Certain LTCC tape systems have coefficients of thermal expansion that are well matched to advanced high temperature semiconductors such as SiC, making them an attractive option for low to mid-volume high temperature products. A computer aided process design kit that supports unified design of high temperature SiC ASICs and the corresponding LTCC module is presented herein. The CAD tools used in the design kit are open source and include basic features such as schematic

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42

Zhu, Xuexin, Haisheng Song, Xiaoyang Niu, and Chengxin Zhao. "A multi-dimensional measurement ASIC for Micro-Pattern Gaseous Detectors." Journal of Instrumentation 20, no. 06 (2025): C06050. https://doi.org/10.1088/1748-0221/20/06/c06050.

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Abstract Micro-Pattern Gaseous Detectors (MPGDs) is a novel type of detector capable of meeting the growing demands of particle and nuclear experiments for enhanced spatial resolution and rate capability. The rapid advancement of MPGDs has imposed increasingly stringent requirements on their readout circuit. Silicon Pixel Detector Readout ASICs, featuring high integration density and position resolution, can serve as readout circuits for MPGDs. We have designed a Silicon Pixel Detectors Readout ASIC, called IMPix-N2, that introduces a new readout architecture for MPGDs applications. The ASIC c

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de Geronimo, Gianluigi, George Iakovidis, Sorin Martoiu, and Venetios Polychronakos. "The VMM3a ASIC." IEEE Transactions on Nuclear Science 69, no. 4 (2022): 976–85. http://dx.doi.org/10.1109/tns.2022.3155818.

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Bray, Natasha. "ASIC inhibits addiction." Nature Reviews Neuroscience 15, no. 8 (2014): 496. http://dx.doi.org/10.1038/nrn3789.

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López, Juan Carlos. "ASIC-nal integrator." Nature Reviews Neuroscience 3, no. 10 (2002): 763. http://dx.doi.org/10.1038/nrn950.

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Poikela, T., R. Ballabriga, J. Buytaert, et al. "The VeloPix ASIC." Journal of Instrumentation 12, no. 01 (2017): C01070. http://dx.doi.org/10.1088/1748-0221/12/01/c01070.

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Bailey, A., T. Lada, and J. Preston. "Collateral ASIC test." IEEE Design & Test of Computers 14, no. 1 (1997): 55–63. http://dx.doi.org/10.1109/54.573368.

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Levitt, M. E. "ASIC testing upgraded." IEEE Spectrum 29, no. 5 (1992): 26–29. http://dx.doi.org/10.1109/6.135405.

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Lynagh, Timothy, Yana Mikhaleva, Janne M. Colding, Joel C. Glover, and Stephan A. Pless. "Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes." Proceedings of the National Academy of Sciences 115, no. 33 (2018): 8430–35. http://dx.doi.org/10.1073/pnas.1806614115.

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Acid-sensing ion channels (ASICs) are proton-gated ion channels broadly expressed in the vertebrate nervous system, converting decreased extracellular pH into excitatory sodium current. ASICs were previously thought to be a vertebrate-specific branch of the DEG/ENaC family, a broadly conserved but functionally diverse family of channels. Here, we provide phylogenetic and experimental evidence that ASICs are conserved throughout deuterostome animals, showing that ASICs evolved over 600 million years ago. We also provide evidence of ASIC expression in the central nervous system of the tunicate,

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Springauf, Andreas, Pia Bresenitz, and Stefan Gründer. "The Interaction between Two Extracellular Linker Regions Controls Sustained Opening of Acid-sensing Ion Channel 1." Journal of Biological Chemistry 286, no. 27 (2011): 24374–84. http://dx.doi.org/10.1074/jbc.m111.230797.

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Activation of acid-sensing ion channels (ASICs) contributes to neuronal death during stroke, to axonal degeneration during neuroinflammation, and to pain during inflammation. Although understanding ASIC gating may help to modulate ASIC activity during these pathologic situations, at present it is poorly understood. The ligand, H+, probably binds to several sites, among them amino acids within the large extracellular domain. The extracellular domain is linked to the two transmembrane domains by the wrist region that is connected to two anti-parallel β-strands, β1 and β12. Thus, the wrist region

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