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Artykuły w czasopismach na temat „Auto-inducers”

Autor: Grafiati

Data publikacji: 24 sierpnia 2024

Data aktualizacji: 31 lipca 2025

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1

SHIN, Hwain, Kazuya OKADA, John C. WILKINSON, et al. "Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein." Biochemical Journal 373, no. 3 (2003): 965–71. http://dx.doi.org/10.1042/bj20030583.

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The execution phase of apoptosis is under the control of members of the inhibitor of apoptosis (IAP) family of zinc finger proteins. Several of these proteins contain a C-terminal RING (really interesting new gene) domain that has been postulated to regulate ubiquitination of themselves or their target proteins, thereby modulating thresholds for apoptosis. We demonstrate that the auto-ubiquitination sites of the X-linked IAP (XIAP) are Lys322 and Lys328, located in the third baculovirus IAP repeat domain of the protein. Modification of these sites to arginine dramatically reduces ubiquitinatio

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D.K., Choudhary, and Sandhu S.S. "Quorum Sensing (QS) As Etiological Phenomenon: The Bacterial Paradigm." PJSR 2, no. 2 (2009): 1–4. https://doi.org/10.5281/zenodo.8296428.

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Signaling mechanisms that govern physiological and morphological responses to change the cell density are common in bacteria. Quorum sensing is signal transduction processes which involves the production and release of and response to hormone-like molecules (auto-inducers) that accumulate in the external environment as the cell population grows. Quorum sensing is found in a wide variety of bacteria, both Gram-positive and Gram-negative and the spectrum of physiological functions that can be regulated is impressive. Variation in the nature of the extra-cellular signal in the signal detection ma

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Gonzalez-Chapa, Jorge Armando, Marina Barguil Macêdo, and Christian Lood. "The Emerging Role of Mitochondrial Dysfunction in the Pathogenesis of Idiopathic Inflammatory Myopathies." Rambam Maimonides Medical Journal 14, no. 2 (2023): e0006. http://dx.doi.org/10.5041/rmmj.10493.

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Increasing evidence points towards mitochondria as crucial players in the initiation and progression of auto-immune and degenerative disorders, to which impaired cell metabolism is but a facet of the subjacent etiopathogenesis. This review aims to introduce the reader to essential concepts of mitochondrial abnormalities in idiopathic inflammatory myopathy (IIM), underscoring inclusion-body myositis and dermatomyositis. Far surpassing the initial simplistic view of being responsible for energy generation, mitochondria have gathered attention regarding their role in inflammatory processes, being

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TANAKA, Motoyuki, Stephan R. Krutzik, Peter A. Sieling, Thomas H. Rea та Robert L. Modlin. "Fcγ receptor activation triggers monocytes to differentiate into CD1b+ immature dendritic cells (B138)". Journal of Immunology 178, № 1_Supplement (2007): LB29. http://dx.doi.org/10.4049/jimmunol.178.supp.b138.

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Abstract Antibodies are potent inducers of inflammation and Fcγ receptors (FcγRs) are considered as important immune-regulators linked to infection immunity, cancer immunity and auto-immunity. We previously reported that CD1b+ dendritic cells (DC) are differentially distributed in leprosy lesions and contribute to the in pathophysiology of the polarized clinical spectrum of the disease. Here we demonstrate that activation of FcγRs on human blood monocytes triggers monocyte differentiation into CD1b+ cells. The CD1b+ population increased in a dose-dependent manner, and the differentiation was b

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Morgan-Sagastume, Fernando, Nico Boon, Sofie Dobbelaere, Tom Defoirdt, and Willy Verstraete. "Production of acylated homoserine lactones byAeromonasandPseudomonasstrains isolated from municipal activated sludge." Canadian Journal of Microbiology 51, no. 11 (2005): 924–33. http://dx.doi.org/10.1139/w05-077.

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Up to now, the production and role of N-acyl homoserine lactones (AHLs) in activated sludge have been poorly understood. In this study, cross-feeding assays with the reporter strains Agrobacterium tumefaciens NTL4 and Chromobacterium violaceum CV026 were used to investigate AHL signal production by municipal activated sludge samples. AHL signal production was consistently detected from municipal activated sludge when different samples were incubated on nutrient media. From one municipal activated sludge sample, 10 strains producing AHL-like auto inducers were isolated by an overlay technique.

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6

Haniyya, Haniyya, Dini Achnafani, Maria Ulfah, Niknik Nurhayati, and Is Helianti. "The utilization of auto-inducible Plyb promoter and media optimation for cell density-dependent expression of recombinant xylanase in Bacillus subtilis DB104." Microbiology Indonesia 14, no. 1 (2020): 2. http://dx.doi.org/10.5454/mi.14.1.2.

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Strong promoters are one of the fundamental aspects to increase the level of gene expression, and one of approach to improve the recombinant enzyme productivity so that the efficiency of production cost for enzyme production in industrial scale can be reached. Here we assessed the application of a cell density-dependent promoter and media optimation to promote cell growth and protein expression of Bacillus subtilis without excess usage of inducers. An auto-inducible Pylb promoter that is potential to provide inducer-free enzyme production was cloned and introduced into xylanase recombinant sys

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Hetta, Helal F., Yasmin N. Ramadan, Zainab I. Rashed, et al. "Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria." Molecules 29, no. 15 (2024): 3466. http://dx.doi.org/10.3390/molecules29153466.

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Antibiotic resistance is a major problem and a major global health concern. In total, there are 16 million deaths yearly from infectious diseases, and at least 65% of infectious diseases are caused by microbial communities that proliferate through the formation of biofilms. Antibiotic overuse has resulted in the evolution of multidrug-resistant (MDR) microbial strains. As a result, there is now much more interest in non-antibiotic therapies for bacterial infections. Among these revolutionary, non-traditional medications is quorum sensing inhibitors (QSIs). Bacterial cell-to-cell communication

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8

Noori, Noorgul, Ahmad Wali Ataye, Abdul Musawer Bayan, Rafiullah Shirzadi, and Mohammad Esmail Ahmadyar. "Structural Insights into Taxifolin's Potential Inhibition of AHL Synthase via Molecular Docking and Dynamics Simulations." Afghanistan Journal of Basic Medical Science 2, no. 1 (2025): 24–36. https://doi.org/10.62134/khatamuni.53.

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Background: The extensive application of antibiotics for bacterial disease treatment has resulted in the emergence of antibiotic resistance and biofilm formation, a significant issue that contributes to increased illness and death rates. Quorum sensing (QS) is cell-cell communication in bacteria involved in the formation of biofilm in which this pathway is triggered by signaling molecules called auto inducers. Inhibition of enzymes that produce such signaling molecules, for instance, acyl-homoserine lactone synthase (AHL) in QS would be appreciable to enhance the effect of antibiotics and prev

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9

Naik, Varsha, and Girish Mahajan. "Quorum Sensing: A Non-conventional Target for Antibiotic Discovery." Natural Product Communications 8, no. 10 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801030.

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Quorum sensing (QS) is known to regulate different functions viz. pathogenesis, biofilm formation, and host colonization, along with other functions by regulating bacterial virulence determinants. Therefore, QS is deemed to be an interesting target to modulate pathogenesis. Also, there have been global reports of continuous emergence of antibiotic-resistant microbes; hence, an alternative treatment that compliments antibiotic activity is highly desirable. One such approach is to look for QS inhibitors, which can quench the virulence phenotypes exerted by pathogenic bacteria and compliment anti

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10

Mujawdiya, Pavan K., and Suman Kapur. "Modulation of Gut Microbiota through Dietary Phytochemicals as a Novel Anti-infective Strategy." Current Drug Discovery Technologies 17, no. 4 (2020): 498–506. http://dx.doi.org/10.2174/1570163816666191107124214.

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: Quorum Sensing (QS) is a phenomenon in which bacterial cells communicate with each other with the help of several low molecular weight compounds. QS is largely dependent on population density, and it triggers when the concentration of quorum sensing molecules accumulate in the environment and crosses a particular threshold. Once a certain population density is achieved and the concentration of molecules crosses a threshold, the bacterial cells show a collective behavior in response to various chemical stimuli referred to as “auto-inducers”. The QS signaling is crucial for several phenotypic

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11

Isibor, PO, PA Akinduti, OS Aworunse, et al. "Significance of African Diets in Biotherapeutic Modulation of the Gut Microbiome." Bioinformatics and Biology Insights 15 (January 2021): 117793222110126. http://dx.doi.org/10.1177/11779322211012697.

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Diet plays an essential role in human development and growth, contributing to health and well-being. The socio-economic values, cultural perspectives, and dietary formulation in sub-Saharan Africa can influence gut health and disease prevention. The vast microbial ecosystems in the human gut frequently interrelate to maintain a healthy, well-coordinated cellular and humoral immune signalling to prevent metabolic dysfunction, pathogen dominance, and induction of systemic diseases. The diverse indigenous diets could differentially act as biotherapeutics to modulate microbial abundance and popula

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12

Zarzyńska, Joanna, Małgorzata Gajewska та Tomasz Motyl. "Effects of hormones and growth factors on TGF-β1 expression in bovine mammary epithelial cells". Journal of Dairy Research 72, № 1 (2005): 39–48. http://dx.doi.org/10.1017/s0022029904000639.

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The decline of mammary epithelial cell (MEC) number during mammary gland involution in the cow is due to inhibition of proliferation and induction of apoptosis. Transforming growth factor-beta 1 (TGF-β1) belongs to a group of intramammary auto/paracrine inhibitors of bovine MEC growth and inducers of apoptosis. However, the mechanism responsible for the regulation of TGF-β1 expression in MEC is not known. The present study examined the effect of the hormones, growth hormone (GH), somatostatin (STS), 17-β oestradiol (E2), progesterone (P4), as well as the growth factors, insulin-like growth fac

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13

Mariño, Guillermo, Federico Pietrocola, Frank Madeo, and Guido Kroemer. "Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers." Autophagy 10, no. 11 (2014): 1879–82. http://dx.doi.org/10.4161/auto.36413.

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Man, Na, and Shu-Hong Yu. "Rare earth oxide nanocrystals as a new class of autophagy inducers." Autophagy 6, no. 2 (2010): 310–11. http://dx.doi.org/10.4161/auto.6.2.11138.

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15

Ullah, Aqsa Sana. "Microbial Quorum Sensing and Its Role in Biofilm Formation." Asian Journal of Biology, July 15, 2020, 34–40. http://dx.doi.org/10.9734/ajob/2020/v9i330089.

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Quorum sensing is defined as the effect of fluctuation in cells density on the regulation of gene expression within the cell. Approximately all bacteria produce small molecules (auto-inducers) to control Quorum sensing. S-adenosylmethionine (SAM) is responsible for auto-inducers production in Gram-negative bacteria. Auto-inducers interaction with particular receptors provokes different behaviours that are under the control of Quorum sensing The presence of fungal Quorum sensing systems was bare eleven years before after the sighting that farnesol panels filamentation in the pathogenic polymorp

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16

Huang, Jingwen, Jiuzhou Chen, Yu Wang, et al. "Development of a Hyperosmotic Stress Inducible Gene Expression System by Engineering the MtrA/MtrB-Dependent NCgl1418 Promoter in Corynebacterium glutamicum." Frontiers in Microbiology 12 (July 21, 2021). http://dx.doi.org/10.3389/fmicb.2021.718511.

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Corynebacterium glutamicum is an important workhorse for industrial production of diversiform bioproducts. Precise regulation of gene expression is crucial for metabolic balance and enhancing production of target molecules. Auto-inducible promoters, which can be activated without expensive inducers, are ideal regulatory tools for industrial-scale application. However, few auto-inducible promoters have been identified and applied in C. glutamicum. Here, a hyperosmotic stress inducible gene expression system was developed and used for metabolic engineering of C. glutamicum. The promoter of NCgl1

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17

Tumminia, Matteo, Dario Valentini, Giovanni Pace, et al. "Maximum Likelihood Identification of Cavitation Instabilities in Axial Inducers." Journal of Fluids Engineering, September 3, 2022. http://dx.doi.org/10.1115/1.4055473.

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Abstract The article illustrates the results of an exploratory study on the effectiveness of maximum likelihood Bayesian estimation in the identification of cavitation instabilities in axial inducers using the blade-to-blade pressure measured by a single transducer flush-mounted on the impeller casing. The typical azimuthal distribution of the pressure in the blade channels is parameterized and modulated in space and time for theoretically reproducing the expected pressure generated by known forms of cavitation instabilities (cavitation surge auto-oscillations, n-lobed synchronous/asynchronous

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18

Naga, Nourhan G., Dalia E. El-Badan, Khaled M. Ghanem, and Mona I. Shaaban. "It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy." Cell Communication and Signaling 21, no. 1 (2023). http://dx.doi.org/10.1186/s12964-023-01154-9.

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AbstractMultiple drug resistance poses a significant threat to public health worldwide, with a substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies to control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulates bacterial virulence factors through cell-to-cell signaling networks. AIs are small signaling molecules produced during the stationary phase. When bacterial cultures reach a certain level of growth, these molecules regulate the expression of the bound genes by acting as mirrors that reflec

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19

Hariri, Neda, Karim Sorkheh, and Leila Nejadsadeghi. "Aeromonas hydrophila by Quorum Sensing Auto-Inducers on Growth Amelioration, Enhance Salt Tolerance and Mechanism of Encoding Genes in Rapeseed." Journal of Plant Growth Regulation, February 7, 2025. https://doi.org/10.1007/s00344-025-11656-0.

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Vani, S., Kayeen Vadakkan, and Bince Mani. "A narrative review on bacterial biofilm: its formation, clinical aspects and inhibition strategies." Future Journal of Pharmaceutical Sciences 9, no. 1 (2023). http://dx.doi.org/10.1186/s43094-023-00499-9.

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Abstract Background The predominant mode of life of most of the bacteria is their biofilm state. Based on the type of bacteria existing within the biofilm, it might be beneficial or harmful. Its beneficial aspects have been exploited mostly in waste management strategies. These biofilms affected the food industry, dairy industry and oil industry, causing huge losses by food spoilage, reduced heat transfer efficiencies and corrosion caused by biofilms in pipelines. They were considered a crucial risk to human well-being. Biofilms were responsible for more than 75% of the clinical infections cau

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Coculo, Laura, Marius Wits, Irene Mariani, et al. "Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions." Cell Death Discovery 11, no. 1 (2025). https://doi.org/10.1038/s41420-025-02393-0.

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Abstract Heterozygous mutations in the Bone morphogenetic protein (BMP) type I receptor ACVR1, encoding activin-like kinase 2 (ALK2), underlie all cases of the rare genetic musculoskeletal disorder Fibrodysplasia Ossificans Progressiva (FOP). The most commonly found mutant ALK2 p.R206H receptor variant exhibits loss of auto inhibition of BMP signaling and can be activated by Activins, while wild-type receptors remain unresponsive. Consequently, the downstream chondrogenic signaling is enhanced, thus driving heterotopic ossification within soft connective tissues. Despite several investigationa

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Gimpel, Anna-Katharina, Antonio Maccataio, Harald Unterweger, Maria V. Sokolova, Georg Schett, and Ulrike Steffen. "IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes." Frontiers in Immunology 12 (January 13, 2022). http://dx.doi.org/10.3389/fimmu.2021.761816.

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Neutrophil extracellular trap (NET) formation is a powerful instrument to fight pathogens, but may induce collateral damage in the affected tissues. Besides pathogen-derived factors, immune complexes are potent inducers of NET formation. Neutrophils express IgA and IgG specific Fc receptors (FcRs) and therefore respond to complexed IgA and IgG. Especially in the context of autoimmune diseases, IgA and IgG immune complexes have been shown to trigger NET formation, a process that putatively contributes to disease severity. However, it is of question if both antibody classes stimulate neutrophils

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23

Hartmann, Anton, Sophia Klink, and Michael Rothballer. "Plant Growth Promotion and Induction of Systemic Tolerance to Drought and Salt Stress of Plants by Quorum Sensing Auto-Inducers of the N-acyl-homoserine Lactone Type: Recent Developments." Frontiers in Plant Science 12 (May 31, 2021). http://dx.doi.org/10.3389/fpls.2021.683546.

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Kachhadiya, Dimple K., and John J. Georrge. "Quorum Sensing and its Inhibition in Pseudomonas aeruginosa: Molecular Targets and Mode of Action." Current Drug Targets 26 (April 17, 2025). https://doi.org/10.2174/0113894501373124250410105111.

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Abstract: Biofilms are complicated microbial communities attached to surfaces, bringing about serious clinical, industrial, and environmental issues due to their resistance to conventional antimicrobial treatments. One critical factor of biofilm formation and persistence is quorum sensing - a mechanism that enables cell-to-cell communication and controls the gene expression pattern depending on the population density. It is based on the constant production, secretion, and response of small signalling molecules, termed auto-inducers. The main role of QS is the regulation of vital processes in t

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de Carvalho Oliveira, Vanessa, Olga Tatsiy, and Patrick P. McDonald. "Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus." Frontiers in Immunology 14 (January 24, 2023). http://dx.doi.org/10.3389/fimmu.2023.1042686.

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Neutrophil extracellular traps (NETs) serve to immobilize and kill pathogens, but also can contribute to the progression of several inflammatory and auto-immune diseases, as well as cancer. Whence the importance of elucidating the mechanisms underlying NET formation. In this regard, the PI3K signaling pathway has been shown to be crucial; yet little is known about which of its components are involved. Here, we identified the PI3K isoforms and associated signaling partners that are mobilized in response to different classes of physiological NET inducers (inflammatory cytokines, growth factors,

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26

Chao, Shuangying, Yuhang Liu, Ning Ding, et al. "Highly Expressed Soluble Recombinant Anti-GFP VHHs in Escherichia coli via Optimized Signal Peptides, Strains, and Inducers." Frontiers in Molecular Biosciences 9 (March 10, 2022). http://dx.doi.org/10.3389/fmolb.2022.848829.

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Antigen-binding variable domains of the H chain of heavy-chain antibodies (VHHs), also known as nanobodies (Nbs), are of great interest in imaging technique, disease prevention, diagnosis, and therapy. High-level expression of soluble Nbs is very important for its industrial production. In this study, we optimized the expression system of anti-green fluorescent protein (GFP) VHHs with three different signal peptides (SPs), outer-membrane protein A (OmpA), pectate lyase B (PelB), and L-asparaginase II SP (L-AsPsII), in different Escherichia coli strains via isopropyl β-D-thiogalactoside (IPTG)

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