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Artykuły w czasopismach na temat „Autologous chondrocyte implantation Articular cartilage Cartilage repair Review Systemic”

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Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Dewan, Ashvin K., Matthew A. Gibson, Jennifer H. Elisseeff, and Michael E. Trice. "Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/272481.

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Articular cartilage defects have been addressed using microfracture, abrasion chondroplasty, or osteochondral grafting, but these strategies do not generate tissue that adequately recapitulates native cartilage. During the past 25 years, promising new strategies using assorted scaffolds and cell sources to induce chondrocyte expansion have emerged. We reviewed the evolution of autologous chondrocyte implantation and compared it to other cartilage repair techniques.Methods. We searched PubMed from 1949 to 2014 for the keywords “autologous chondrocyte implantation” (ACI) and “cartilage repair” i
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Mistry, Hema, Martin Connock, Joshua Pink, et al. "Autologous chondrocyte implantation in the knee: systematic review and economic evaluation." Health Technology Assessment 21, no. 6 (2017): 1–294. http://dx.doi.org/10.3310/hta21060.

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BackgroundThe surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber. The cells that form the cartilage are called chondrocytes. Natural cartilage is called hyaline cartilage. Articular cartilage has very little capacity for self-repair, so damage may be permanent. Various methods have been used to try to repair cartilage. Autologous chondrocyte implantation (ACI) involves laboratory culture of cartilage-producing cells from the knee and then implanting them
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Ahmadpoor, Xenab, Jessie Sun, Nerone Douglas, Weimin Zhu, and Hang Lin. "Hydrogel-Enhanced Autologous Chondrocyte Implantation for Cartilage Regeneration—An Update on Preclinical Studies." Bioengineering 11, no. 11 (2024): 1164. http://dx.doi.org/10.3390/bioengineering11111164.

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Autologous chondrocyte implantation (ACI) and matrix-induced ACI (MACI) have demonstrated improved clinical outcomes and reduced revision rates for treating osteochondral and chondral defects. However, their ability to achieve lasting, fully functional repair remains limited. To overcome these challenges, scaffold-enhanced ACI, particularly utilizing hydrogel-based biomaterials, has emerged as an innovative strategy. These biomaterials are intended to mimic the biological composition, structural organization, and biomechanical properties of native articular cartilage. This review aims to provi
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Furkan, Ozan. "Improving orthopedic use of stem cell engineering: A mini-review." Ulus Medical Journal 1, no. 1 (2023): 9–11. https://doi.org/10.5281/zenodo.7905315.

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Cell-based therapies for cartilage regeneration have gained popularity as a potential solution to the ongoing problem of articular cartilage repair in orthopedic surgery. There have been some successes with autologous chondrocyte implantation, but there are also some drawbacks. These include limited donor sites, donor site morbidity, dedifferentiation of isolated chondrocytes during monolayer expansion, and poor integration of repair tissue into the native cartilage. The potential of mesenchymal stem cells (MSCs) as a replacement cell source has so gained popularity. Self-renewing, highly expa
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Rehnitz, Christoph, Marc-André Weber, and Felix Wuennemann. "Imaging of the Knee Following Repair of Focal Articular Cartilage Lesions." Seminars in Musculoskeletal Radiology 22, no. 04 (2018): 377–85. http://dx.doi.org/10.1055/s-0038-1667301.

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AbstractFocal chondral or osteochondral lesions of the knee are common lesions involving either the cartilage layers or the cartilage layers and the subchondral bone. Despite their heterogeneous clinical presentation, they are important risk factors for the premature development of osteoarthritis. Therefore, early detection of osteochondral lesions and focal cartilage defects is crucial. In symptomatic (osteo-)chondral lesions, numerous therapeutic strategies, ranging from conservative treatment to surgical procedures such as marrow stimulation, osteochondral autograft transplantation, or auto
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Bailey, Andrea, Nicola Goodstone, Sharon Roberts, et al. "Rehabilitation After Oswestry Autologous-Chondrocyte Implantation: The OsCell Protocol." Journal of Sport Rehabilitation 12, no. 2 (2003): 104–18. http://dx.doi.org/10.1123/jsr.12.2.104.

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Objective:To develop a postoperative rehabilitation protocol for patients receiving autologous-chondrocyte implantation (ACI) to repair articular-cartilage defects of the knee.Data Sources:careful review of both basic science and clinical literature, personal communication with colleagues dealing with similar cases, and the authors’ experience and expertise in rehabilitating numerous patients with knee pathologies, injuries, and trauma.Data Synthesis:Postoperative rehabilitation of the ACI patient plays a critical role in the outcome of the procedure. The goals are to improve function and redu
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Ogura, Takahiro, Tim Bryant, Gergo Merkely, Brian A. Mosier, and Tom Minas. "Survival Analysis of Revision Autologous Chondrocyte Implantation for Failed ACI." American Journal of Sports Medicine 47, no. 13 (2019): 3212–20. http://dx.doi.org/10.1177/0363546519876630.

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Background: Autologous chondrocyte implantation (ACI) provides a successful outcome for treating articular cartilage lesions. However, there have been very few reports on the clinical outcomes of revision ACI for failed ACI. Purpose: To evaluate clinical outcomes in patients who underwent revision ACI of the knee for failure of an initial ACI and to determine the factors affecting the survival rate. Study Design: Case series; Level of evidence, 4. Methods: A review of a prospectively collected data set was performed from patients who underwent revision ACI of the knee for failure of an initial
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Willers, Craig, David J. Wood, and Ming H. Zheng. "A CURRENT REVIEW ON THE BIOLOGY AND TREATMENT OF ARTICULAR CARTILAGE DEFECTS (PART I & PART II)." Journal of Musculoskeletal Research 07, no. 03n04 (2003): 157–81. http://dx.doi.org/10.1142/s0218957703001125.

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Osteochondral injury occurs predominantly in physically active young adult males. Injury to the articular cartilage and/or subchondral bone may not only cause acute joint disease resulting in osseous intracapsular (synovitis) or extracapsular pain, but may also act to spawn arthritic conditions in later life. Since the 18th century, such injury has proven difficult to treat clinically, and much therapy has been essentially palliative. Past treatments such as abrasion arthroplasty, drilling, microfracture and arthroscopic lavage have been useful in removing articular debris and promoting the fo
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Dziewic, Jakub, Maria Przygoda, Joanna Śnieżna, et al. "Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods." Quality in Sport 37 (January 19, 2025): 57092. https://doi.org/10.12775/qs.2025.37.57092.

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Osteoarthritis (OA) is the most common form of chronic joint diseases, and its treatment still remains difficult with the current state of medicine. In this review, modern regenerative methods used in the repair of articular cartilage, both traditional techniques and innovative cellular therapies, are described. It focuses on the most updated treatment modalities, discussing, among other methods, microfracture, osteochondral grafts, autologous chondrocyte implantation (ACI), novel approaches of matrix-assisted autologous chondrocyte transplantation (MACT) and mesenchymal stem cell (MSC) treatm
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Pasic, Nicholas, Hannah L. Bradsell, Andres Barandiaran, et al. "Rate of Conversion to Matrix-Induced Autologous Chondrocyte Implantation After a Biopsy: A Multisurgeon Study." Orthopaedic Journal of Sports Medicine 11, no. 5 (2023): 232596712311607. http://dx.doi.org/10.1177/23259671231160732.

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Background: Autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are performed to treat focal chondral defects (FCDs); both are 2-step procedures involving a biopsy, followed by transplantation. There is little published research evaluating ACI/MACI in patients who undergo a biopsy alone. Purpose: To determine (1) the value of ACI/MACI cartilage biopsies and concomitant procedures in patients with FCDs of the knee and (2) the conversion rate to cartilage transplantation as well as the rate of reoperation. Study Design: Case series; Level of ev
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11

Lamplot, Joseph D., Kevin A. Schafer, and Matthew J. Matava. "Treatment of Failed Articular Cartilage Reconstructive Procedures of the Knee: A Systematic Review." Orthopaedic Journal of Sports Medicine 6, no. 3 (2018): 232596711876187. http://dx.doi.org/10.1177/2325967118761871.

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Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have investigated outcomes of revision surgery after a failed attempt at cartilage repair or reconstruction. Purpose: To investigate outcomes of revision cartilage restoration procedures for symptomatic articular cartilage lesions of the knee following a previously failed cartilage reconstructive procedure. Study Design: Systematic review; Level of evidence, 4
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Gao, Liang, Patrick Orth, Magali Cucchiarini, and Henning Madry. "Autologous Matrix-Induced Chondrogenesis: A Systematic Review of the Clinical Evidence." American Journal of Sports Medicine 47, no. 1 (2017): 222–31. http://dx.doi.org/10.1177/0363546517740575.

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Background: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed “autologous matrix-induced chondrogenesis” (AMIC). Purpose: To examine the current clinical evidence regarding AMIC for focal chondral defects. Study Design: Systematic review. Methods: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases. Inclusion criteria were clinical studies of AMIC for articular cartilage repair, written in English. Relative data were extracted and critically analyzed. PR
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Nimkingratana, Puwapong, and Mats Brittberg. "Returning to Work After Articular Cartilage Repair Intervention: A Systematic Review." Orthopaedic Journal of Sports Medicine 8, no. 3 (2020): 232596712090552. http://dx.doi.org/10.1177/2325967120905526.

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Background: The process of returning to work after cartilage treatment has not been studied in depth, even though a better understanding of potential outcomes could lead to significant benefits for the general population. Purpose: To determine which surgical interventions are most effective in helping patients return to work after cartilage repair and to identify factors that affect the ability to return to work. Study Design: Systematic review; Level of evidence, 4. Methods: This systematic review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines
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Jarecki, Jaromir, Marcin Krzysztof Waśko, Wojciech Widuchowski, et al. "Knee Cartilage Lesion Management—Current Trends in Clinical Practice." Journal of Clinical Medicine 12, no. 20 (2023): 6434. http://dx.doi.org/10.3390/jcm12206434.

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Many patients, particularly those aged above 40, experience knee joint pain, which hampers both sports activities and daily living. Treating isolated chondral and osteochondral defects in the knee poses a significant clinical challenge, particularly in younger patients who are not typically recommended partial or total knee arthroplasty as alternatives. Several surgical approaches have been developed to address focal cartilage defects. The treatment strategies are characterized as palliation (e.g., chondroplasty and debridement), repair (e.g., drilling and microfracture), or restoration (e.g.,
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Valtanen, Rosa S., Armin Arshi, Benjamin V. Kelley, Peter D. Fabricant, and Kristofer J. Jones. "Articular Cartilage Repair of the Pediatric and Adolescent Knee with Regard to Minimal Clinically Important Difference: A Systematic Review." CARTILAGE 11, no. 1 (2018): 9–18. http://dx.doi.org/10.1177/1947603518783503.

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Objective To perform a systematic review of clinical outcomes following microfracture (MFX), autologous chondrocyte implantation (ACI), osteochondral allograft transplantation (OCA), and osteochondral autograft transplantation system (OATS) to treat articular cartilage lesions in pediatric and adolescent patients. We sought to compare postoperative improvements for each cartilage repair method to minimal clinically important difference (MCID) thresholds. Design MEDLINE, Web of Science, Scopus, and Cochrane Library databases were searched for studies reporting MCID-validated outcome scores in a
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Bright, Philip, and Karen Hambly. "A Systematic Review of Reporting of Rehabilitation in Articular-Cartilage-Repair Studies of Third-Generation Autologous Chondrocyte Implantation in the Knee." Journal of Sport Rehabilitation 23, no. 3 (2014): 182–91. http://dx.doi.org/10.1123/jsr.2013-0045.

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Context:Autologous chondrocyte implantation (ACI) is a tissue-engineered surgical technique initially developed for articular cartilage repair of isolated chondral lesions of the knee. Third-generation techniques (ACI3) are now available that deliver autologous cultured chondrocytes into the defect using cell scaffolds. The successful outcomes of these techniques have some dependency on presurgical and postsurgical patient rehabilitation.Objectives:To determine if the standard of reporting for rehabilitation has improved in ACI3 studies; previous reviews in this field recommended describing th
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Salem, Hytham S., Zaira Chaudhry, Ludovico Lucenti, Bradford S. Tucker, and Kevin B. Freedman. "The Importance of Staging Arthroscopy for Chondral Defects of the Knee." Orthopaedic Journal of Sports Medicine 7, no. 7_suppl5 (2019): 2325967119S0026. http://dx.doi.org/10.1177/2325967119s00261.

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Objectives: Chondral injures of the knee are a common source of pain in athletes. The specificity and sensitivity of MRI in evaluating chondral defects of the knee have been found to be as low as 73% and 42%, respectively. Staging arthroscopy is a more accurate method of evaluating the articular surfaces of the knee prior to cartilage restoration surgery or meniscal allograft transplantation (MAT). Addressing all concomitant pathology can be important for the success of cartilage restoration surgery, and treatment plan may change based on the extent and location of cartilage damage. The purpos
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18

Karnovsky, Sydney C., Bridget DeSandis, Amgad M. Haleem, Carolyn M. Sofka, Martin O’Malley, and Mark C. Drakos. "Comparison of Juvenile Allogenous Articular Cartilage and Bone Marrow Aspirate Concentrate Versus Microfracture With and Without Bone Marrow Aspirate Concentrate in Arthroscopic Treatment of Talar Osteochondral Lesions." Foot & Ankle International 39, no. 4 (2018): 393–405. http://dx.doi.org/10.1177/1071100717746627.

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Background: The purpose of this study was to compare the functional and radiographic outcomes of patients who received juvenile allogenic chondrocyte implantation with autologous bone marrow aspirate (JACI-BMAC) for treatment of talar osteochondral lesions with those of patients who underwent microfracture (MF). Methods: A total of 30 patients who underwent MF and 20 who received DeNovo NT for JACI-BMAC treatment between 2006 and 2014 were included. Additionally, 17 MF patients received supplemental BMAC treatment. Retrospective chart review was performed and functional outcomes were assessed
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Zhao, Xia, Daniel A. Hu, Di Wu, et al. "Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering." Frontiers in Bioengineering and Biotechnology 9 (March 25, 2021). http://dx.doi.org/10.3389/fbioe.2021.603444.

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Cartilage, especially articular cartilage, is a unique connective tissue consisting of chondrocytes and cartilage matrix that covers the surface of joints. It plays a critical role in maintaining joint durability and mobility by providing nearly frictionless articulation for mechanical load transmission between joints. Damage to the articular cartilage frequently results from sport-related injuries, systemic diseases, degeneration, trauma, or tumors. Failure to treat impaired cartilage may lead to osteoarthritis, affecting more than 25% of the adult population globally. Articular cartilage has
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Naveen, Sangeetha, Noorzurani Robson, and Tunku Kamarul. "Comparative analysis of autologous chondrocyte implantation and other treatment modalities: a systematic review." Springer, June 19, 2017. https://doi.org/10.5281/zenodo.811454.

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Abstract Purpose: The purpose of this systematic review was to analyze and determine the effectiveness of Autologous Chondrocyte Implantation (ACI) when compared with other treatment modalities which includes microfracture, mosaicplasty, abrasionplasty, bone marrow derived mesenchymal stem cell (BMSC) and matrix assisted autologous chondrocyte implantation (MACI). Methods: Literature search using online databases PubMed, Scopus, National Institute for Clinical Excellence (NICE) and Cochrane Controlled Trial Register regarding all cell based therapies and other interventions for chondral lesion
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Christensen, Bjørn Borsøe, Morten Lykke Olesen, Kris Tvilum Chadwick Hede, Natasja Leth Bergholt, Casper Bindzus Foldager, and Martin Lind. "Particulated Cartilage for Chondral and Osteochondral Repair: A Review." CARTILAGE, February 13, 2020, 194760352090475. http://dx.doi.org/10.1177/1947603520904757.

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Introduction Injuries to articular cartilage have a poor spontaneous repair potential and no gold standard treatment exist. Particulated cartilage, both auto- and allograft, is a promising new treatment method that circumvents the high cost of scaffold- and cell-based treatments. Materials and Methods A comprehensive database search on particulated cartilage was performed. Results Fourteen animal studies have found particulated cartilage to be an effective treatment for cartilage injuries. Many studies suggest that juvenile cartilage has increased regenerative potential compared to adult carti
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Wei, Yuxuan, Hao Guo, Zhuhong Chen, Nian Sun, and Canjun Zeng. "Autologous Costal Chondral/Osteochondral Transplantation and Costa‐Derived Chondrocyte Implantation for Articular Cartilage Repair: Basic Science and Clinical Applications." Orthopaedic Surgery, January 25, 2024. http://dx.doi.org/10.1111/os.13992.

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There has been increasing application of autologous costal chondral/osteochondral transplantation (ACCT/ACOT) and costa‐derived chondrocyte implantation (ACCI) for articular cartilage repair over the past three decades. This review presents the major evidence on the properties of costal cartilage and bone and their qualifications as grafts for articular cartilage repair, the major clinical applications, and the risks and strategies for costal chondral/osteochondral graft(s) harvest. First, costal cartilage has many specific properties that help restore the articular surface. Costa, which can p
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Zheng, Zenghui, Dongmei Yu, Haoyu Wang, et al. "Advancement of 3D biofabrication in repairing and regeneration of cartilage defects." Biofabrication, January 10, 2025. https://doi.org/10.1088/1758-5090/ada8e1.

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Abstract Three-dimensional (3D) bioprinting, an additive manufacturing technology, fabricates biomimetic tissues that possess natural structure and function. It involves precise deposition of bioinks, including cells, and bioactive factors, on basis of computer-aided 3D models. Articular cartilage injurie, a common orthopedic issue. Current repair methods, for instance microfracture procedure (MF), Autologous chondrocyte implantation (ACI), and Osteochondral Autologous Transfer Surgery (OATS) have been applied in clinical practice. However, each procedure has inherent limitation. For instance,
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Zhu, Wenrun, Lu Cao, Chunfeng Song, Zhiying Pang, Haochen Jiang, and Changan Guo. "Cell-derived decellularized extracellular matrix scaffolds for articular cartilage repair." International Journal of Artificial Organs, September 18, 2020, 039139882095386. http://dx.doi.org/10.1177/0391398820953866.

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Articular cartilage repair remains a great clinical challenge. Tissue engineering approaches based on decellularized extracellular matrix (dECM) scaffolds show promise for facilitating articular cartilage repair. Traditional regenerative approaches currently used in clinical practice, such as microfracture, mosaicplasty, and autologous chondrocyte implantation, can improve cartilage repair and show therapeutic effect to some degree; however, the long-term curative effect is suboptimal. As dECM prepared by proper decellularization procedures is a biodegradable material, which provides space for
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Jacob, Connor C., Ryan H. Barnes, Jordan Haber, et al. "Combined Treatment of Articular Cartilage Defects and Patellar Instability with Autologous Chondrocyte Implantation and Patellar Stabilization." Journal of Knee Surgery, April 14, 2025. https://doi.org/10.1055/a-2585-4916.

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Background: High-grade chondral injuries in the setting of patellar instability are a challenging problem for patients and surgeons. In patients undergoing autologous chondrocyte implantation (ACI) to address cartilage defects, medial patellofemoral ligament (MPFL) reconstruction with or without tibial tubercle osteotomy is one option to both treat patellar instability and repair and offload defects. The primary aim of this case series was to describe return to activity, reoperation rates, and instances of recurrent patellar instability after MPFLR with ACI with or without TTO. We also discuss
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Jaiswal, P. K., K. Wong, and W. S. Khan. "Operative Treatment of Knee Cartilage Injuries: A Review of the Current Literature on Non-Cell-Based and Cell-Based Therapies." September 29, 2011. https://doi.org/10.5281/zenodo.7794.

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Aims: Cartilage is frequently damaged through injury and disease but shows little or no capacity for repair. Injuries that extend to the subchondral level show some capacity for repair due to the release of bone marrow derived mesenchymal stem cells. Focal articular cartilage defects are challenging clinical problems that may progress to more generalised lesions. We reviewed the literature to analyse the results of available noncell- based and cell-based strategies for the repair of articular cartilage defects in the knee. Study design: Review Article Place and Duration of Study: University Co
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Shah, Sarav S., and Kai Mithoefer. "Scientific Developments and Clinical Applications Utilizing Chondrons and Chondrocytes with Matrix for Cartilage Repair." CARTILAGE, November 6, 2020, 194760352096888. http://dx.doi.org/10.1177/1947603520968884.

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Injuries to articular cartilage of the knee are increasingly common. The operative management of these focal chondral lesions continues to be problematic for the treating orthopedic surgeon secondary to the limited regenerative capacity of articular cartilage. The pericellular matrix (PCM) is a specialized, thin layer of the extracellular matrix that immediately surrounds chondrocytes forming a unit together called the chondron. The advancements in our knowledge base with regard to the PCM/chondrons as well as interterritorial matrix has permeated and led to advancements in product development
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Bryam Esteban Coello García, Angel Patricio Fajardo Zhao, Byron Xavier Cabrera Castillo, Holger Xavier Rojas Espinoza, Brian Andrés Serpa Ocampo, and Karina Noemí Contreras García. "DEGENERATIVE ARTICULAR CARTILAGE DISEASE, OSTEOARTHROSIS." EPRA International Journal of Multidisciplinary Research (IJMR), February 21, 2023, 232–40. http://dx.doi.org/10.36713/epra12476.

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Introduction: Osteoarthrosis (OA), degenerative articular cartilage disease is a chronic inflammatory arthropathy involving joint elements (subchondral bone, synovial membrane, hyaline cartilage and others). It is due to a disorder in the regulation between degradation and synthesis of the extracellular matrix of cartilage, involving bone and synovial membrane in a biochemical process mediated by growth factors and cytokines which, in turn, intervene in the course of bone remodeling and joint destruction. Objective: to detail the current information related to osteoarthrosis, description, etio
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de Albuquerque, Joao Bourbon, Caleb Bischoff, Brett Crist, Aaron Stoker, James Cook, and Steven DeFroda. "Poster 114: Viability and Expression of Chondrocytes Harvested During Arthroscopic Treatment of Femoroacetabular Impingement." Orthopaedic Journal of Sports Medicine 11, no. 7_suppl3 (2023). http://dx.doi.org/10.1177/2325967123s00104.

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Objectives: Chondral lesions of the hip pose a unique and challenging problem for surgeons. These lesions can be encountered frequently during arthroscopic and open hip preservation procedures; however, their clinical significance and definitive management remain controversial. Cartilage restoration procedures within the hip can be invasive and challenging based on the relative difficulties in access and articular surface contour matching in this joint. Cell-based cartilage restoration techniques have become popular for clinical use in other joints. Autologous cartilage implantation (ACI) and
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Stein, Beth E. Shubin, Ryann Davie, Brittany Ammerman, et al. "Poster 240: Radiographic and Patient-Reported Outcomes of Patellar Denovo Procedure in Shouldered Versus Unshouldered Patella Cartilage Lesions." Orthopaedic Journal of Sports Medicine 12, no. 7_suppl2 (2024). http://dx.doi.org/10.1177/2325967124s00209.

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Objectives: Unique challenges exist in treating patellar cartilage defects such as the contour of the articular surface and the high dynamic shear and compressive forces at the trochlear articulation. When considering restoration techniques osteochondral autograft or allograft can be used when the underlying bone is also involved but for isolated chondral defects, cell-based restoration is the standard of care. Previous literature has demonstrated that success of these cell-based therapies depends on a fully shouldered, stable rim of healthy cartilage to achieve repair stability. More recently
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