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Artykuły w czasopismach na temat „Azo compounds Toxicology”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 19 lutego 2022

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1

Sarah Mohammed Abed and Hasan Thamer Ghanem. "Synthesis and characterization Some of heterocyclic compounds from Nitrogen derivative." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (October 16, 2019): 3186–96. http://dx.doi.org/10.26452/ijrps.v10i4.1621.

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This paper involves the synthesis of new oxazepine derivatives by multi-reaction steps. The first step synthesis azo derivative from 2-naphthol with 3-aminoacetophenone. The second step was the condensation reaction between ketone group of the azo compound and different primary aromatic amines (4-amino phenol, 3-nitro aniline and 4-methyl aniline) to yiled new azo Schiff base compounds (S1-S3) respectively. In the final step, Oxazepine compounds (L1-L3)and (L4-L6)were prepared from reaction imine compounds (S1-S3) with maleic and phthalic anhydride in toluene as solvent. All these derivatives

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Gadaleta, Domenico, Nicola Porta, Eleni Vrontaki, Serena Manganelli, Alberto Manganaro, Guido Sello, Masamitsu Honma, and Emilio Benfenati. "Integrating computational methods to predict mutagenicity of aromatic azo compounds." Journal of Environmental Science and Health, Part C 35, no. 4 (October 2, 2017): 239–57. http://dx.doi.org/10.1080/10590501.2017.1391521.

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Tsuda, Shuji, Naonori Matsusaka, Hiroo Madarame, Shunji Ueno, Nobuyuki Susa, Kumiko Ishida, Noriko Kawamura, Kaoru Sekihashi, and Yu F. Sasaki. "The comet assay in eight mouse organs: results with 24 azo compounds." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 465, no. 1-2 (February 2000): 11–26. http://dx.doi.org/10.1016/s1383-5718(99)00199-0.

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Weber, Eric J., and N. Lee Wolfe. "Kinetic studies of the reduction of aromatic AZO compounds in anaerobic sediment/water systems." Environmental Toxicology and Chemistry 6, no. 12 (December 1987): 911–19. http://dx.doi.org/10.1002/etc.5620061202.

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ELENA, PERDUM, MEDVEDOVICI ANDREI VALENTIN, TACHE FLORENTIN, VISILEANU EMILIA, DUMITRESCU IULIANA, MITRAN CORNELIA-ELENA, IORDACHE OVIDIU-GEORGE, and RADULESCU ION RAZVAN. "Some validation aspects on the analytical method for assaying carcinogenic amines from textile dyes." Industria Textila 69, no. 03 (July 1, 2018): 249–56. http://dx.doi.org/10.35530/it.069.03.1521.

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Chemicals safety control and ecological properties have become a priority for the textile industry in order to avoid the negative effects on humans and environment. The increasing interest for toxicology of textiles is determined by the presence of dangerous compounds in clothes generated from dyeing and finishing processes. In order to protect human health, European Regulations as Oeko Tex Standard 100 and REACH Regulation limit the presence of dangerous chemicals, such as aromatic amines, generated by reductive cleavage of azo dyes, by no more than 30 mg/kg of textile material. The main goal

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Shao, Jie, Nicholas E. Geacintov, and Vladimir Shafirovich. "Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine by Oxyl Radicals Produced by Photolysis of Azo Compounds." Chemical Research in Toxicology 23, no. 5 (May 17, 2010): 933–38. http://dx.doi.org/10.1021/tx100022x.

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Rafii, F., and C. E. Cerniglia. "Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract." Environmental Health Perspectives 103, suppl 5 (June 1995): 17–19. http://dx.doi.org/10.1289/ehp.95103s417.

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Cox, Julie A., and Paul A. White. "The mutagenic activity of select azo compounds in MutaMouse target tissues in vivo and primary hepatocytes in vitro." Mutation Research/Genetic Toxicology and Environmental Mutagenesis 844 (August 2019): 25–34. http://dx.doi.org/10.1016/j.mrgentox.2019.06.003.

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Li, Xue, and Yong-min Zhang. "Study on the reactions of azo compounds with acyl halides mediated by Sm/TiCl4." Journal of Zhejiang University SCIENCE B 7, no. 3 (March 2006): 198–201. http://dx.doi.org/10.1631/jzus.2006.b0198.

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Telke, Amar A., Dayanand C. Kalyani, Vishal V. Dawkar, and Sanjay P. Govindwar. "Influence of organic and inorganic compounds on oxidoreductive decolorization of sulfonated azo dye C.I. Reactive Orange 16." Journal of Hazardous Materials 172, no. 1 (December 2009): 298–309. http://dx.doi.org/10.1016/j.jhazmat.2009.07.008.

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Ong, Soon-An, Katsuhiro Uchiyama, Daisuke Inadama, and Kazuaki Yamagiwa. "Simultaneous removal of color, organic compounds and nutrients in azo dye-containing wastewater using up-flow constructed wetland." Journal of Hazardous Materials 165, no. 1-3 (June 15, 2009): 696–703. http://dx.doi.org/10.1016/j.jhazmat.2008.10.071.

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Qin, Xing, Xiaoyun Su, Tao Tu, Jie Zhang, Xiaolu Wang, Yaru Wang, Yuan Wang, et al. "Enzymatic Degradation of Multiple Major Mycotoxins by Dye-Decolorizing Peroxidase from Bacillus subtilis." Toxins 13, no. 6 (June 19, 2021): 429. http://dx.doi.org/10.3390/toxins13060429.

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The co-occurrence of multiple mycotoxins, including aflatoxin B1 (AFB1), zearalenone (ZEN) and deoxynivalenol (DON), widely exists in cereal-based animal feed and food. At present, most reported mycotoxins degrading enzymes target only a certain type of mycotoxins. Therefore, it is of great significance for mining enzymes involved in the simultaneous degradation of different types of mycotoxins. In this study, a dye-decolorizing peroxidase-encoding gene BsDyP from Bacillus subtilis SCK6 was cloned and expressed in Escherichia coli BL21/pG-Tf2. The purified recombinant BsDyP was capable of oxid

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Manahil B Elamin, Amani Abd Elrazig Salman Abd Elaziz, and Emad Mohamed Abdallah. "Benzothiazole moieties and their derivatives as antimicrobial and antiviral agents: A mini-review." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 8, 2020): 3309–15. http://dx.doi.org/10.26452/ijrps.v11i3.2459.

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Heterocyclic chemistry has provided an inexhaustible source of pharmaceutical molecules. Heterocyclic compounds such as benzothiazole moieties and its derivatives area substantial class of compounds in pharmaceutical chemistry and exhibited therapeutic capabilities, such as antitumor, anticancer, antioxidant, antidiabetic, antiviral, antimicrobial, antimalarial, anthelmintic and other activities. Besides, some antibiotics such as penicillin and cephalosporin have heterocyclic moiety. The growing prevalence of multi-drug resistant pathogens represents serious global concern,which requires the d

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Luo, Yiqi Ruben, Cassandra Yun, and Kara L. Lynch. "Quantitation of Cannabinoids in Breath Samples Using a Novel Derivatization LC–MS/MS Assay with Ultra-High Sensitivity." Journal of Analytical Toxicology 43, no. 5 (April 5, 2019): 331–39. http://dx.doi.org/10.1093/jat/bkz023.

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Abstract As the legalization of medical and recreational marijuana use expands, measurement of tetrahydrocannabinol (THC) in human breath has become an area of interest. The presence and concentration of cannabinoids in breath have been shown to correlate with recent marijuana use and may be correlated with impairment. Given the low concentration of THC in human breath, sensitive analytical methods are required to further evaluate its utility and window of detection. This paper describes a novel derivatization method based on an azo coupling reaction that significantly increases the ionization

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Francesconi, Kevin A. "Arsenic species in seafood: Origin and human health implications." Pure and Applied Chemistry 82, no. 2 (January 16, 2010): 373–81. http://dx.doi.org/10.1351/pac-con-09-07-01.

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The presence of arsenic in marine samples was first reported over 100 years ago, and shortly thereafter it was shown that common seafood such as fish, crustaceans, and molluscs contained arsenic at exceedingly high concentrations. It was noted at the time that this seafood arsenic was probably present as an organically bound species because the concentrations were so high that if the arsenic had been present as an inorganic species it would certainly have been toxic to the humans consuming seafood. Investigations in the late 1970s identified the major form of seafood arsenic as arsenobetaine [

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Kurochka, Andrey V., Ol'ga V. Agafonova, Aleksandr S. Losev, Elizaveta A. Mamaeva, Sergey Yu Bylikin, Vadim V. Negrebetsky, Evgeniya P. Kramarova, Aleksandr G. Shipov, and Yuri I. Baukov. "Six- and Seven-Membered 1-Oxa-4-Aza-2-Silacyclanes as Possible Correctors of Adaptational Mechanisms." Metal-Based Drugs 5, no. 1 (January 1, 1998): 25–33. http://dx.doi.org/10.1155/mbd.1998.25.

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The biological activity of eight 1-oxa-4-aza-2-silacyclanes with the OSiCH2N fragment including 6-membered 2-sila-5-morpholinones (1–3) and 4-acyl-2-silamorpholines (4–6)and previously unknown 7-membered derivatives of salicylic acid (7, 8) was studied. Compounds 1 and 3–6 show the certain antihypoxic action. Compounds 2 (40 mg/kg), 4 (20 mg/kg), 6 (40 mg/kg), 7 (20 mg/kg) and 8 (40 mg/kg) reduce the physical serviceability of intact animals. Compound 1 (20 mg/kg) influences the physical serviceability in a moderate-positive way on the background of chlorophos-poisoning. Compounds 5–8 displaye

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Kitada, Shinichi, Christina L. Kress, Maryla Krajewska, Lee Jia, Maurizio Pellecchia, and John C. Reed. "Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)." Blood 111, no. 6 (March 15, 2008): 3211–19. http://dx.doi.org/10.1182/blood-2007-09-113647.

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Abstract Altered expression of Bcl-2 family proteins plays central roles in apoptosis dysregulation in cancer and leukemia, promoting malignant cell expansion and contributing to chemoresistance. In this study, we compared the toxicity and efficacy in mice of natural product gossypol and its semisynthetic derivative apo-gossypol, compounds that bind and inhibit antiapoptotic Bcl-2 family proteins. Daily oral dosing studies showed that mice tolerate doses of apogossypol 2- to 4-times higher than gossypol. Hepatotoxicity and gastrointestinal toxicity represented the major adverse activities of g

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Newman, L. M., R. L. Giacobbe, L.-J. Fu, and E. M. Johnson. "Developmental Toxicity Evaluation of Several Cosmetic Ingredients in the Hydra Assay." Journal of the American College of Toxicology 9, no. 3 (May 1990): 361–65. http://dx.doi.org/10.3109/10915819009078745.

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The developmental toxicity hazard potential of six cosmetic products was determined in the in vitro Hydra assay. These studies were conducted to supplement available toxicological information and provide an indication of the priority of these compounds for higher level (in vivo) developmental toxicity testing. All but one ingredient, potassium sorbate, was predicted by the assay to be generally equally or more toxic to adults than to embryos and, therefore, to be low-priority chemicals for more elaborate tests. In contrast, assay results suggest that potassium sorbate is a prime candidate for

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Hijaz, Faraj, and Nabil Killiny. "Evaluation of Oxytetracycline Metabolites Cross-Reactivity with Oxytetracycline Enzyme-Linked Immunosorbent Assay (ELISA)." Antibiotics 9, no. 4 (April 15, 2020): 183. http://dx.doi.org/10.3390/antibiotics9040183.

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Antibiotics have been successfully used for the control of several plant diseases for many years. Recently, streptomycin and oxytetracycline have been approved for the treatment of Huanglongbing (HLB) in Florida. The enzyme-linked immunosorbent assay (ELISA) is the most commonly used assay for the detection of these antibiotics because it is quick, simple, and can be used to analyze many samples at the same time. However, ELISA can react with the metabolites of the parent compound and its structurally related compounds. In this study, we investigated the cross-reactivity of the oxytetracycline

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Hubbs, Ann F., Kathleen Kreiss, Kristin J. Cummings, Kara L. Fluharty, Ryan O’Connell, Allison Cole, Tiana M. Dodd, et al. "Flavorings-Related Lung Disease: A Brief Review and New Mechanistic Data." Toxicologic Pathology 47, no. 8 (October 23, 2019): 1012–26. http://dx.doi.org/10.1177/0192623319879906.

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Flavorings-related lung disease is a potentially disabling and sometimes fatal lung disease of workers making or using flavorings. First identified almost 20 years ago in microwave popcorn workers exposed to butter-flavoring vapors, flavorings-related lung disease remains a concern today. In some cases, workers develop bronchiolitis obliterans, a severe form of fixed airways disease. Affected workers have been reported in microwave popcorn, flavorings, and coffee production workplaces. Volatile α-dicarbonyl compounds, particularly diacetyl (2,3-butanedione) and 2,3-pentanedione, are implicated

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Zhu, Jianyu, Jeffrey Meeusen, Susan Krezoski, and David H. Petering. "Reactivity of Zn-, Cd-, and Apo-Metallothionein with Nitric Oxide Compounds: In Vitro and Cellular Comparison." Chemical Research in Toxicology 23, no. 2 (February 15, 2010): 422–31. http://dx.doi.org/10.1021/tx900387k.

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Ye, Yuerong, Colin C. Duke, and Gerald M. Holder. "Identification of Hepatic Metabolites of Two Highly Carcinogenic Polycyclic Aza-Aromatic Compounds, 7,9-Dimethylbenz[c]acridine and 7,10-Dimethylbenz[c]acridine." Chemical Research in Toxicology 8, no. 2 (March 1995): 188–202. http://dx.doi.org/10.1021/tx00044a003.

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Cervantes, G., V. Moreno, E. Molins, and C. Miravitlles. "Reactions of Pd(II) and Pt(II) Complexes With Tetraethylthiouram Disulfide." Metal-Based Drugs 4, no. 6 (January 1, 1997): 317–25. http://dx.doi.org/10.1155/mbd.1997.317.

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The reactions of tetraethylthiouram disulfide (DTS), an inhibitor of the nephrotoxicity of Pt(II) drugs, an efficient agent in the treatment of chronic alcoholism, in the treatment of HIV infections, AIDS and heavy metal toxicity, and a fungicide and herbicide, with K2[PtCl4], in ratio 1:1 and 1:2, gave the compounds [PtCl2DTS] and [Pt(S2CNEt2)2] respectively. The reaction of the complexes K2[PdCl4], Pd(AcO)2 and [PdCl2(PhCN)2], where PhCN = Benzonitrile, with tetraethylthiouram disulfide in ratio 1:1 or 1:2, yielded orange crystals identified as [Pd(S2CNEt2)2]. The crystals were suitable for

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Vedika Dadlani, Pushpendra Tripathi, and Rakesh Somani. "Design, Molecular Docking and In-Silico Analysis of Novel thiadiazole-azetidinone hybrids as Potential Antitubercular Agents." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (November 29, 2019): 3694–703. http://dx.doi.org/10.26452/ijrps.v10i4.1756.

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The recent emergence of extensively drug-resistant tuberculosis has become a cause of concern for the management of tuberculosis globally. Shikimic acid pathway seems to be a potential and favorable target for the drug design of new anti-infective agents. This work aims to change the focus from traditional cell approaches to the target-based design of novel thiadiazolyl-azetidinone derivatives with Shikimate kinase as the drug target for anti-tubercular activity. Thiadiazole and azetidinone derivatives were methodically reprised to design a series of 3-chloro-4-(aryl)-1-(5-sulfanyl-1,3,4-thiad

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Shah, Syed Muhammad Ali, Muhammad Akram, Muhammad Riaz, Naveed Munir, and Ghulam Rasool. "Cardioprotective Potential of Plant-Derived Molecules: A Scientific and Medicinal Approach." Dose-Response 17, no. 2 (April 1, 2019): 155932581985224. http://dx.doi.org/10.1177/1559325819852243.

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Since the beginning of human civilization, plants have been used in alleviating the human distress and it was recorded for about thousands of years ago that the plants are being used for medicinal purposes. Natural bioactive compounds called phytochemicals are obtained from medicinal plants, vegetables, and fruits, which functions to combat against various ailments. There is dire need to explore the plant biodiversity for its medicinal and pharmacological potentials. Different databases such as Google scholar, Medline, PubMed, and the Directory of Open Access Journals were searched to find the

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Karadag, AS, M. Kavala, FT Demir, Z. Turkoğlu, İ. Kartal, and E. Zemheri. "A case of hyperpigmentation and acanthosis nigricans by testosterone injections." Human & Experimental Toxicology 33, no. 12 (February 6, 2014): 1297–301. http://dx.doi.org/10.1177/0960327113514099.

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Drug-related skin disorders may occur in many different ways. Despite pigmentary changes being less important for morbidity, these changes precipitate depressed mood and reduce self-confidence. Testosterone is a steroid hormone from the androgen group and primarily used for the treatment of hypogonadism in males. Testosterone replacement can cause skin problems like acne, hair loss, redness, pain, or infection at the injection site. The study was conducted on a 49-year-old man with adult onset idiopathic hypogonadotropic hypogonadism, which is an acquired form of isolated gonadotropin-releasin

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Barreiro, Carlos, Juan F. Martín, and Carlos García-Estrada. "Proteomics Shows New Faces for the Old Penicillin ProducerPenicillium chrysogenum." Journal of Biomedicine and Biotechnology 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/105109.

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Fungi comprise a vast group of microorganisms including the Ascomycota (majority of all described fungi), the Basidiomycota (mushrooms or higher fungi), and the Zygomycota and Chytridiomycota (basal or lower fungi) that produce industrially interesting secondary metabolites, such as β-lactam antibiotics. These compounds are one of the most commonly prescribed drugs world-wide. Since Fleming's initial discovery ofPenicillium notatum80 years ago, the role ofPenicilliumas an antimicrobial source became patent. After the isolation ofPenicillium chrysogenumNRRL 1951 six decades ago, classical mutag

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Duringer, Jennifer, Rajarshi Mazumder, Valerie Palmer, A. Morrie Craig, and Peter Spencer. "Case-Control Study of Nodding Syndrome in Acholiland: Urinary Multi-Mycotoxin Screening." Toxins 13, no. 5 (April 27, 2021): 313. http://dx.doi.org/10.3390/toxins13050313.

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This case-control study adds to the growing body of knowledge on the medical, nutritional, and environmental factors associated with Nodding Syndrome (NS), a seizure disorder of children and adolescents in northern Uganda. Past research described a significant association between NS and prior history of measles infection, dependence on emergency food and, at head nodding onset, subsistence on moldy maize, which has the potential to harbor mycotoxins. We used LC-MS/MS to screen for current mycotoxin loads by evaluating nine analytes in urine samples from age-and-gender matched NS cases (n = 50)

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Khawla Salman Abd-Alrassol, Qutaiba A. Qasim, Maitham Ali AL-Rikabi, and H. N. K. AL-Salman. "The development of analytical methods to determine metoclopramide-hydrochloric acid in the standard raw and it compared with pharmaceuticals." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (November 5, 2019): 3461–74. http://dx.doi.org/10.26452/ijrps.v10i4.1663.

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The three novel easy, to the prepare and sensitive spectral methods, were used to estimate metoclopramide in both standard and pharmaceuticals. The effective double–electron, was present in the metoclopramide compound helps to interact in an acidic medium with a reagent such as diazetide resorcinol and 8-hydroxyquinoline reagents. The present article was extended to find out three analytical methods with UV-V is the detector. In both A and B methods, two azo-dyes are formed, they are orange-red and red stable and have high water solubility, giving highest absorption values at 415 nm and 485 nm

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Sips, Luc, Emmanuel Njumbe Ediage, Benno Ingelse, Tom Verhaeghe, and Lieve Dillen. "LC–MS quantification of oligonucleotides in biological matrices with SPE or hybridization extraction." Bioanalysis 11, no. 21 (November 2019): 1941–54. http://dx.doi.org/10.4155/bio-2019-0117.

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Aim: Quantitative LC–MS analysis of oligonucleotides (OGNs) in biological matrices is needed to support candidate selection of new therapeutic OGNs. Methodology & results: A set of 20 single stranded antisense oligonucleotides (ASO) and five siRNAs were extracted from plasma and tissue homogenates. Anion Exchange (AEX) SPE was selected as generic extraction approach, resulting in recoveries from plasma >70%. Extraction from tissue homogenates showed often more variation and lower recoveries. A proof of concept of a novel tailored hybridization extraction is demonstrated for two 16-mer r

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Singh, P., B. Morris, S. Zhao, and B. L. Blaylock. "Suppression of the Contact Hypersensitivity Response Following Topical Exposure to 2-Butoxyethanol in Female BALB/c Mice." International Journal of Toxicology 21, no. 2 (March 2002): 107–14. http://dx.doi.org/10.1080/10915810252866088.

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The effects of route of exposure, time of exposure and metabolism of 2-butoxyethanol (BE) on the contact hypersensitivity response (CHR) were evaluated in female BALB/c mice. Mice were either orally exposed to 50, 150 or 400 mg BE/kg or topically exposed to 0.25, 1.0, 4.0 or 16.0 mg BE on the ear and the oxazolone (OXA)-induced CHR evaluated by measuring ear thickness before and after OXA challenge. While no modulation was observed following oral exposure to BE, topical exposure resulted in a significant decrease in the CHR. Application of 4.0 mg BE in 4:1 acetone and olive oil (AOO) vehicle a

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Bagdonienė, Lida, Danutė Labeikytė, Ivars Kalviņš, Veronika Borutinskaitė, Aleksandrs Prokofjevs, Pēteris Trapencieris, Benediktas Juodka, and Nikolajs Sjakste. "Rat Serum Carboxylesterase Partly Hydrolyses Gamma-Butyrobetaine Esters." Archives of Industrial Hygiene and Toxicology 60, no. 2 (June 1, 2009): 147–56. http://dx.doi.org/10.2478/10004-1254-60-2009-1915.

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Rat Serum Carboxylesterase Partly Hydrolyses Gamma-Butyrobetaine EstersAlthough described some time ago, gamma-butyrobetaine esters and related compounds have not gained much attention from researchers, and their physiological function remains obscure. Formerly we detected GBB-esterase enzymatic activity in rat blood serum using phenylated gamma-butyrobetaine as an artificial substrate of the enzyme and HPLC. The aim of the present work was to develop an assay that would enable spectrophotometric or colorimetric determination of the reaction products of GBB-esterase activity and to reveal indi

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Romero-Palomo, Fernando, Matthias Festag, Barbara Lenz, Simone Schadt, Andreas Brink, Anja Kipar, Bernd Steinhuber, et al. "Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats." Toxicologic Pathology 49, no. 6 (June 1, 2021): 1174–92. http://dx.doi.org/10.1177/01926233211011615.

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Antisense oligonucleotides (ASOs) are chemically modified nucleic acids with therapeutic potential, some of which have been approved for marketing. We performed a study in rats to investigate mechanisms of toxicity after administration of 3 tool locked nucleic acid (LNA)-containing ASOs with differing established safety profiles. Four male rats per group were dosed once, 3, or 6 times subcutaneously, with 7 days between dosing, and sacrificed 3 days after the last dose. These ASOs were either unconjugated (naked) or conjugated with N-acetylgalactosamine for hepatocyte-targeted delivery. The ma

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Marwal, Avinash, Mukesh Meena, and RK Gaur. "Molecular Docking Studies of Coronavirus Proteins with Medicinal Plant Based Phytochemicals." Defence Life Science Journal 6, no. 1 (February 23, 2021): 57–63. http://dx.doi.org/10.14429/dlsj.6.15704.

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In this study, we presented an in silico molecular docking between the SARS-CoV-2 four proteins [(a) SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain (6M3M), (b) Nsp9 RNA binding protein of SARS CoV-2 (6W4B), (c) The crystal structure of COVID-19 main protease in apo form (6M03), and (d) Structure of the 2019-nCoV HR2 Domain (6LVN)] available in the PDB (Protein Data Bank), and the medicinal plant-based phytochemicals (retrieved from PubChem database) as ligand molecules i.e. Piperine (Black Pepper), Eugenol (Clove), Alliin (Garlic), Gingerol (Ginger) and Curcumin (Turmeric). All

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Hijaz, Faraj, Yasser Nehela, Pedro Gonzalez-Blanco, and Nabil Killiny. "Development of Europium-Sensitized Fluorescence-Based Method for Sensitive Detection of Oxytetracycline in Citrus Tissues." Antibiotics 10, no. 2 (February 23, 2021): 224. http://dx.doi.org/10.3390/antibiotics10020224.

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Antimicrobial compounds have been successfully used to control many plant and animal diseases. Recently, oxytetracycline (OTC) and streptomycin have been approved for the treatment of Huanglongbing in citrus. Since the application of OTC is under strict regulations, several methods have been developed to determine and monitor its levels in the environment including high-performance liquid chromatography, ELISA, colorimetric, and fluorometric assays. In this study, we developed a fluorometric method for the determination of OTC in plant tissues based on its complexation with europium. Our preli

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Iseppi, Ramona, Martina Mariani, Carla Condò, Carla Sabia, and Patrizia Messi. "Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections." Antibiotics 10, no. 4 (April 10, 2021): 417. http://dx.doi.org/10.3390/antibiotics10040417.

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The emergence of antibiotic-resistant bacteria has become a major concern worldwide. This trend indicates the need for alternative agents to antibiotics, such as natural compounds of plant origin. Using agar disc diffusion and minimum inhibitory concentration (MIC) assays, we investigated the antimicrobial activity of Citrus aurantium (AEO), Citrus x limon (LEO), Eucalyptus globulus (EEO), Melaleuca alternifolia (TTO), and Cupressus sempervirens (CEO) essential oils (EOs) against three representatives of antibiotic-resistant pathogens and respective biofilms: vancomycin-resistant enterococci (

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McLean, Thomas C., Barrie Wilkinson, Matthew I. Hutchings, and Rebecca Devine. "Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis." Antibiotics 8, no. 2 (June 18, 2019): 83. http://dx.doi.org/10.3390/antibiotics8020083.

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Discovering new antibiotics is vital to combat the growing threat of antimicrobial resistance. Most currently used antibiotics originate from the natural products of actinomycete bacteria, particularly Streptomyces species, that were discovered over 60 years ago. However, genome sequencing has revealed that most antibiotic-producing microorganisms encode many more natural products than previously thought. Biosynthesis of these natural products is tightly regulated by global and cluster situated regulators (CSRs), most of which respond to unknown environmental stimuli, and this likely explains

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Stapp, William B., and Nicholas Polunin. "Global Environmental Education: Towards a Way of Thinking and Acting." Environmental Conservation 18, no. 1 (1991): 13–18. http://dx.doi.org/10.1017/s037689290002124x.

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Our world of Mankind and Nature is becoming more and more seriously threatened as human populations and profligacy increase. Yet short of near-future calamity, there should be hope in global environmental education as a basis for countering such threats as those of world hunger, acidic precipitation, increasing desertification, nuclear proliferation, ‘greenhouse’ warming, and stratospheric ozone depletion. We need to educate people throughout the world to see these dangers in their global context and to act always within this perspective — be they decision-makers, legislators, or mere private

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Israa N. Witwit, Husham M. Mubark, Hutham Mahmood Yousif Al-Labban, and Ahmed Abdul jabbar jaloob Aljanaby. "synthesis and characterization of new imidazole azo ligand with some of transition metal ions, and their biological effect on two pathogenic bacteria of burn patients." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (July 12, 2019). http://dx.doi.org/10.26452/ijrps.v10i3.1382.

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New imidazole azo ligand (DPIDA) was prepared by coupling reaction between 4,5-di phenyl imidazole and N1,N1-dimethylbenzene1,4-diamine di hydrochloride and studied the complexation of this ligand with Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) , and Hg(II) ions , The free ligand and it’s complexes characterized by Mass, 1HNMR, IR, UV-Vis. , and molar conductivity that indicated the octahedral geometry of them with a bidentate ligand which coordinated from (N3) atom of imidazole ring and one nitrogen atom of azo group.Biological activity of ligand (DPIDA) and it's complexes tested aga

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Kumar, M. Sathish, and M. Vijey Aanandhi. "Design, Molecular docking, Synthesis and Biological evaluation of 5, 7 dimethyl pyrido(2, 3-d)pyrimidin-4-one and 4,5 dihydro pyrazolo (3, 4-d) pyrimidines for cytotoxic activity." Research Journal of Pharmacy and Technology, June 29, 2021, 3029–38. http://dx.doi.org/10.52711/0974-360x.2021.00530.

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The fused pyrimidine derivatives are potent tyrosine kinase and thymidylate synthase inhibitors. The compound 3-(4-sulphonyl amino)-2-methyl thio-6-phenyl azo-5, 7-dimethyl pyrido(2,3-d)pyrimidin-4-one was synthesized from Ethyl 2-amino-4,6-dimethylpyridine-3-carboxylate, benzene diazonium chloride, benzene sulphonyl amino isothiocyanate in subsequent reactions. 1-(1, 3-benzothiazol-2-yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidines were synthesized from 1, 3-benzothiazole, 2-thiol, Hydrazine Hydrate, 2-hydrazinyl-1, 3-benzothiazole and aldehydes in subsequent reactions. Twenty-five derivat

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Hassan Abood, Zeid, Zahraa Kadum Chafcheer, and Husham Attallah Suhail. "Synthesis and Antibacterial Evaluation of 1,3-Benzoxazepine-1,5-diones bearing Benzothiazole Moiety." Research Journal of Pharmacy and Technology, April 29, 2021, 1905–9. http://dx.doi.org/10.52711/0974-360x.2021.00336.

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Azo-aldehyde derivative (2) was prepared through reaction of 2-hydroxybenzaldehyde with diazonium ion generated from 2-aminobenzothiazole (1). The producing aldehyde (2) was then treated with some anilines consisting (4-nitroaniline, 3-nitroaniline, 4-aminophenol, 4-methoxyaniline, 4-bromoaniline, 4-chloroaniline and 2,4-dichloroaniline) by (MW) method to give seven Schiff bases (3a-g). Cyloaddition reactions of Schiff bases (3a-g) and phthalic anhydride utilizing (MW) means in dry benzene yielded seven new 1,3-benzoxazepine-1,5-diones (4a-g) carrying the unit of benzothiazole. Determination o

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Adeleye, Olutayo Ademola, Oluyemisi Adebowale Bamiro, Lateef Gbenga Bakre, Florence Olubola Odeleye, Modupe Nofisat Adebowale, Olufemi Lionel Okunye, Mariam Adeola Sodeinde, Adannaya Charity Adebona, and Farid Menaa. "Medicinal Plants with Potential Inhibitory Bioactive Compounds against Coronaviruses." Advanced Pharmaceutical Bulletin, January 30, 2021. http://dx.doi.org/10.34172/apb.2022.003.

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Medicinal plant is a major source of drug discovery for disease management. Over 85% of the population in Asia and in the Middle East use herbal medicine for disease management such as SARS caused by coronavirus. Infection from coronavirus is initiated by entry of the virus into a susceptible host cell. The two human coronaviruses of public health importance two decades ago were SARS-CoV and MERS-CoV and now SARS-CoV 2. These three viruses belong to the same class of beta coronavirus and are somewhat similar in genome sequencing, life cycle, mode of entry into a host, mode of transmission and

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