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Artykuły w czasopismach na temat „Basigin receptor”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Chen, Li, Jiajia Bi, Masaaki Nakai та ін. "Expression of basigin in reproductive tissues of estrogen receptor-α or -β null mice". REPRODUCTION 139, № 6 (2010): 1057–66. http://dx.doi.org/10.1530/rep-10-0069.

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Basigin plays important roles in both male and female reproduction because basigin (Bsg) null male and female mice are infertile. The aim of the present study was to determine whether basigin expression in reproductive organs requires estrogen receptor-α (ESR1, ERα) or -β (ESR2, ERβ). Expression of basigin protein in the testis, ovary, and male and female reproductive tracts was studied in adult wild-type (WT),Esr1-null (αERKO), andEsr2-null (βERKO) mice by immunohistochemistry and immunoblotting. Basigin mRNA levels in ovary and uterus were examined by quantitative RT-PCR. In females, basigin

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King, Nadine R., Catarina Martins Freire, Jawida Touhami, Marc Sitbon, Ashley M. Toye, and Timothy J. Satchwell. "Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1." PLOS Pathogens 20, no. 2 (2024): e1011989. http://dx.doi.org/10.1371/journal.ppat.1011989.

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Plasmodium falciparum invasion of the red blood cell is reliant upon the essential interaction of PfRh5 with the host receptor protein basigin. Basigin exists as part of one or more multiprotein complexes, most notably through interaction with the monocarboxylate transporter MCT1. However, the potential requirement for basigin association with MCT1 and the wider role of basigin host membrane context and lateral protein associations during merozoite invasion has not been established. Using genetically manipulated in vitro derived reticulocytes, we demonstrate the ability to uncouple basigin ect

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Belton, Robert J., Li Chen, Fernando S. Mesquita, and Romana A. Nowak. "Basigin-2 Is a Cell Surface Receptor for Soluble Basigin Ligand." Journal of Biological Chemistry 283, no. 26 (2008): 17805–14. http://dx.doi.org/10.1074/jbc.m801876200.

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Mygind, Kasper J., Denise Nikodemus, Sebastian Gnosa та ін. "ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins". International Journal of Molecular Sciences 25, № 11 (2024): 5871. http://dx.doi.org/10.3390/ijms25115871.

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Desmoplasia is a common feature of aggressive cancers, driven by a complex interplay of protein production and degradation. Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface. Given that soluble basigin is increased in the circulation of patients with a poor cancer prognosis, we explored the putative role of the ADAM12-generated basigin ectodomain in cancer progression. We show that recombinant basigin ectodomain binds β1 integrin and stimulates gelatin degradation and the migration of cancer cells in a matrix metallopro

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Zenonos, Zenon A., Sara K. Dummler, Nicole Müller-Sienerth, et al. "Basigin is a druggable target for host-oriented antimalarial interventions." Journal of Experimental Medicine 212, no. 8 (2015): 1145–51. http://dx.doi.org/10.1084/jem.20150032.

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Plasmodium falciparum is the parasite responsible for the most lethal form of malaria, an infectious disease that causes a large proportion of childhood deaths and poses a significant barrier to socioeconomic development in many countries. Although antimalarial drugs exist, the repeated emergence and spread of drug-resistant parasites limit their useful lifespan. An alternative strategy that could limit the evolution of drug-resistant parasites is to target host factors that are essential and universally required for parasite growth. Host-targeted therapeutics have been successfully applied in

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Le Guennec, Loic, Zoé Virion, Haniaa Bouzinba-Ségard, et al. "Receptor recognition by meningococcal type IV pili relies on a specific complex N-glycan." Proceedings of the National Academy of Sciences 117, no. 5 (2020): 2606–12. http://dx.doi.org/10.1073/pnas.1919567117.

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Bacterial infections are frequently based on the binding of lectin-like adhesins to specific glycan determinants exposed on host cell receptors. These interactions confer species-specific recognition and tropism for particular host tissues and represent attractive antibacterial targets. However, the wide structural diversity of carbohydrates hampers the characterization of specific glycan determinants. Here, we characterized the receptor recognition of type IV pili (Tfp), a key adhesive factor present in numerous bacterial pathogens, using Neisseria meningitidis as a model organism. We found t

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Drzymała, Adam. "The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19." International Journal of Molecular Sciences 25, no. 17 (2024): 9635. http://dx.doi.org/10.3390/ijms25179635.

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Angiotensin-converting enzyme 2 (ACE2) is considered a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor of high importance, but due to its non-ubiquitous expression, studies of other proteins that may participate in virus internalisation have been undertaken. To date, many alternative receptors have been discovered. Their functioning may provide an explanation for some of the events observed in severe COVID-19 that cannot be directly explained by the model in which ACE2 constitutes the central point of infection. Diabetes mellitus type 2 (T2D) can induce severe COVID-19 de

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8

Crosnier, Cécile, Leyla Y. Bustamante, S. Josefin Bartholdson, et al. "Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum." Nature 480, no. 7378 (2011): 534–37. http://dx.doi.org/10.1038/nature10606.

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Patarroyo, Manuel Alfonso, Jessica Molina-Franky, Marcela Gómez, Gabriela Arévalo-Pinzón, and Manuel Elkin Patarroyo. "Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion." International Journal of Molecular Sciences 21, no. 13 (2020): 4729. http://dx.doi.org/10.3390/ijms21134729.

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Protein-protein interactions (IPP) play an essential role in practically all biological processes, including those related to microorganism invasion of their host cells. It has been found that a broad repertoire of receptor-ligand interactions takes place in the binding interphase with host cells in malaria, these being vital interactions for successful parasite invasion. Several trials have been conducted for elucidating the molecular interface of interactions between some Plasmodium falciparum and Plasmodium vivax antigens with receptors on erythrocytes and/or reticulocytes. Structural infor

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Luddi, Alice, Francesca Paola Luongo, Filippo Dragoni, et al. "Cellular and Molecular Mechanisms of In Vivo and In Vitro SARS-CoV-2 Infection: A Lesson from Human Sperm." Cells 11, no. 17 (2022): 2631. http://dx.doi.org/10.3390/cells11172631.

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Despite the major target of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, being the respiratory system, clinical evidence suggests that the male reproductive system may represent another viral target organ. Revealing the effect of SARS-CoV-2 infection on testis and sperm is a priority for reproductive biology, as well as for reproductive medicine. Here, we confirmed that the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on human testis and ejaculated sperm; moreover, we provide evidence for the expression of the

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Adimulam, Theolan, Thilona Arumugam, Anmol Gokul, and Veron Ramsuran. "Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities." International Journal of Molecular Sciences 24, no. 10 (2023): 8711. http://dx.doi.org/10.3390/ijms24108711.

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a global pandemic, with an alarming infectivity and mortality rate. Studies have examined genetic effects on SARS-CoV-2 disease susceptibility and severity within Eurasian populations. These studies identified contrasting effects on the severity of disease between African populations. Genetic factors can explain some of the diversity observed within SARS-CoV-2 disease susceptibility and severity. Single nucleotide polymorphisms (SNPs) within the SARS-CoV-2 receptor genes have demonstrated detrimental and pr

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Reddy, K. Sony, Alok K. Pandey, Hina Singh, et al. "Bacterially Expressed Full-Length Recombinant Plasmodium falciparum RH5 Protein Binds Erythrocytes and Elicits Potent Strain-Transcending Parasite-Neutralizing Antibodies." Infection and Immunity 82, no. 1 (2013): 152–64. http://dx.doi.org/10.1128/iai.00970-13.

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ABSTRACTPlasmodium falciparumreticulocyte binding-like homologous protein 5 (PfRH5) is an essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an attractive malaria vaccine candidate, as it is expressed by a wide number ofP. falciparumstrains, cannot be genetically disrupted, and exhibits limited sequence polymorphisms. Viral vector-induced PfRH5 antibodies potently inhibited erythrocyte invasion. However, it has been a challenge to generate full-length recombinant PfRH5 in a bacterial-cell-based expression system. In this study, we have produced full-length r

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13

Rathore, Sumit, Sheena Dass, Divya Kandari, Inderjeet Kaur, Mayank Gupta, and Yagya D. Sharma. "Basigin Interacts withPlasmodium vivaxTryptophan-rich Antigen PvTRAg38 as a Second Erythrocyte Receptor to Promote Parasite Growth." Journal of Biological Chemistry 292, no. 2 (2016): 462–76. http://dx.doi.org/10.1074/jbc.m116.744367.

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Hudecz, Diana, Molly C. McCloskey, Sandra Vergo, Søren Christensen, James L. McGrath, and Morten S. Nielsen. "Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device." International Journal of Molecular Sciences 24, no. 6 (2023): 5624. http://dx.doi.org/10.3390/ijms24065624.

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Understanding the vesicular trafficking of receptors and receptor ligands in the brain capillary endothelium is essential for the development of the next generations of biologics targeting neurodegenerative diseases. Such complex biological questions are often approached by in vitro models in combination with various techniques. Here, we present the development of a stem cell-based human in vitro blood-brain barrier model composed of induced brain microvascular endothelial cells (iBMECs) on the modular µSiM (a microdevice featuring a silicon nitride membrane) platform. The µSiM was equipped wi

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Reddy, K. Sony, Emmanuel Amlabu, Alok K. Pandey, Pallabi Mitra, Virander S. Chauhan, and Deepak Gaur. "Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial forPlasmodium falciparumerythrocyte invasion." Proceedings of the National Academy of Sciences 112, no. 4 (2015): 1179–84. http://dx.doi.org/10.1073/pnas.1415466112.

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Erythrocyte invasion byPlasmodium falciparummerozoites is a highly intricate process in whichPlasmodium falciparumreticulocyte binding-like homologous protein 5 (PfRH5) is an indispensable parasite ligand that binds with its erythrocyte receptor, Basigin. PfRH5 is a leading blood-stage vaccine candidate because it exhibits limited polymorphisms and elicits potent strain-transcending parasite neutralizing antibodies. However, the mechanism by which it is anchored to the merozoite surface remains unknown because both PfRH5 and the PfRH5-interacting protein (PfRipr) lack transmembrane domains and

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Seizer, Peter, Oliver Borst, Harald Langer, et al. "EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction." Thrombosis and Haemostasis 101, no. 04 (2009): 682–86. http://dx.doi.org/10.1160/th08-06-0368.

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SummaryThe Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types. During cellular interactions homotypic EMMPRIN-EMMPRIN interactions are known to induce the synthesis of matrix metalloproteinases. Recently, we have identified EMMPRIN as a novel receptor on platelets. To our knowledge EMMPRIN has not been shown to serve as adhesion receptor, yet. Here we characterise platelet glycoprotein VI (GPVI) as a novel adhesion receptor for EMMPRIN. Human platelets were prestimulated with ADP and perfused over immobili

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Guney, Ceren, and Fatma AKAR. "Epithelial and Endothelial Expressions of ACE2: SARS-CoV-2 Entry Routes." Journal of Pharmacy & Pharmaceutical Sciences 24 (February 21, 2021): 84–93. http://dx.doi.org/10.18433/jpps31455.

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Angiotensin converting enzyme 2 (ACE2) is a main receptor for SARS-CoV-2 entry to the host cell. ACE2 is one of the key enzymes in renin-angiotensin system and plays a vital role in the maintenance of cardiovascular function. ACE/ACE2 balance is critical in the regulation of blood pressure, electrolyte homeostasis, vascular and cardiac remodeling and inflammation. ACE2 was shown to be abundantly present in human epithelial cells of the lung and enterocytes of the small intestine as well as in endothelial cells of the arterial and venous vessels. ACE2 and TMPRSS2 are colocalized on the cell sur

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18

Al-Saigh, Noor N., Amani A. Harb, and Shtaywy Abdalla. "Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects." International Journal of Molecular Sciences 25, no. 15 (2024): 8527. http://dx.doi.org/10.3390/ijms25158527.

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Olfactory perception is an important physiological function for human well-being and health. Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has received considerable attention, especially in persistent cases that take a long time to recover. This review discusses the integration of different components of the olfactory epithelium to serve as a structural and functional unit and explores how they are affected during viral infections, leading to the development of olfactory dysfunction. The review mainly focused on

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Guo, Hongfang, Rajwali Khan, Sayed Haidar Abbas Raza, et al. "RNA-Seq Reveals Function of Bta-miR-149-5p in the Regulation of Bovine Adipocyte Differentiation." Animals 11, no. 5 (2021): 1207. http://dx.doi.org/10.3390/ani11051207.

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Intramuscular fat is a real challenge for the experts of animal science to improve meat quality traits. Research on the mechanism of adipogenesis provides invaluable information for the improvement of meat quality traits. This study investigated the effect of bta-miR-149-5p and its underlying mechanism on lipid metabolism in bovine adipocytes. Bovine adipocytes were differentiated and transfected with bta-miR-149-5p mimics or its negative control (NC). A total of 115 DEGs including 72 upregulated and 43 downregulated genes were identified in bovine adipocytes. The unigenes and GO term biologic

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Pandit, Nisha Kumari, Simranjeet Singh Mann, Anee Mohanty, and Sumer Singh Meena. "e-Pharmacophore modeling and in silico study of CD147 receptor against SARS-CoV-2 drugs." Genomics & Informatics 21, no. 2 (2023): e17. http://dx.doi.org/10.5808/gi.23005.

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Coronavirus has left severe health impacts on the human population, globally. Still a significant number of cases are reported daily as no specific medications are available for its effective treatment. The presence of the CD147 receptor (human basigin) on the host cell facilitates the severe acute respiratory disease coronavirus 2 (SARS-CoV-2) infection. Therefore, the drugs that efficiently alter the formation of CD147 and spike protein complex could be the right drug candidate to inhibit the replication of SARS-CoV-2. Hence, an e-Pharmacophore model was developed based on the receptor-ligan

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Zhong, Fang-yuan, Yi-chao Zhao, Chen-xu Zhao, et al. "The Role of CD147 in Pathological Cardiac Hypertrophy Is Regulated by Glycosylation." Oxidative Medicine and Cellular Longevity 2022 (January 20, 2022): 1–19. http://dx.doi.org/10.1155/2022/6603296.

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CD147, also known as EMMPRIN or basigin, is a transmembrane glycoprotein receptor that activates matrix metalloproteinases and promotes inflammation. CD147 function is regulated by posttranslational modifications of which glycosylation has attracted the most attention. In this study, we demonstrated that glycosylated CD147 was the dominant form in heart tissue, and its levels were markedly elevated in response to transverse aortic constriction (TAC). Adeno-associated virus 9-mediated, cardiac-specific overexpression of wild-type CD147 in mice significantly promoted pressure overload-induced pa

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Satoh, Kimio, Kota Suzuki, Shinichiro Sunamura, et al. "Crucial Roles of Rho-kinase, Cyclophilin A and its Receptor, Basigin, for Cardiac Hypertrophy, Fibrosis and Failure-Novel Therapeutic Targets." Journal of Cardiac Failure 21, no. 10 (2015): S158. http://dx.doi.org/10.1016/j.cardfail.2015.08.080.

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Nur Hakiki, Ahmad Rizki, Siswoyo, Jon Hafan Sutawardana, Murtaqib, and Rismawan Adi Yunanto. "An Overview of Ocular Transmission as Alternative Route Transmission Coronavirus Disease 2019 (COVID-19): Literature Review." Nursing and Health Sciences Journal (NHSJ) 3, no. 1 (2023): 95–108. http://dx.doi.org/10.53713/nhs.v3i1.182.

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Coronavirus Disease 2019 (COVID-19) becomes a health crisis in the world. The main route of spreading COVID-19 is through the respiratory tract, but this virus also spread through extra respiratory route. This literature review aimed to describe the ocular transmission as an alternative route of COVID-19 transmission. This literature review study used sources of article obtained through ProQuest, Springer, ScienceDirect, PubMed, and Google Scholar with range 2019-2020 publication years and were traced using a combination of search term for ocular transmission, virus receptor, eye manifestation

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Kongsomboonvech, Angel K., Praveesh Valissery, Nichole D. Salinas, Niraj Tolia, and Elizabeth S. Egan. "Cross-Linking of Erythrocyte CD44 Promotes Plasmodium Falciparum Invasion." Blood 144, Supplement 1 (2024): 942. https://doi.org/10.1182/blood-2024-210869.

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Malaria remains a global threat to public health, as drug resistance continues to emerge and vaccines have limited efficacy. Malaria symptoms include the classical fever and chills, which correlate with the asexual life cycle of Plasmodium falciparum parasites in human red blood cells (RBCs). P. falciparum invasion of RBCs requires several host-parasite interactions, some of which have potential as therapeutic or vaccine targets. The roles of host RBC factors involved in malaria parasite invasion remain underexplored, in part because mature enucleated RBCs are refractory to genetic manipulatio

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Mahmoud, Abeer M., and Mohamed M. Ali. "High Glucose and Advanced Glycation End Products Induce CD147-Mediated MMP Activity in Human Adipocytes." Cells 10, no. 8 (2021): 2098. http://dx.doi.org/10.3390/cells10082098.

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Basigin (CD147) is a transmembrane glycoprotein that regulates several physiological processes, including the production and activity of matrix metalloproteinases (MMPs). The activity of CD147 depends mainly on its glycosylation, which varies among pathophysiological conditions. However, it is unknown whether CD147 activity or its function in MMP regulation are affected by the diabetic environment, which is characterized by high glucose (HG) levels and an excess of glycation end products (AGEs). In this study, we investigated the effect of HG and AGEs on CD147 expression in human adipocytes. W

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Babal, Pavel, Lucia Krivosikova, Lucia Sarvaicova, et al. "Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case?" Viruses 13, no. 12 (2021): 2545. http://dx.doi.org/10.3390/v13122545.

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Background: SARS-CoV-2 infection in pregnant women can lead to placental damage and transplacental infection transfer, and intrauterine fetal demise is an unpredictable event. Case study: A 32-year-old patient in her 38th week of pregnancy reported loss of fetal movements. She overcame mild COVID-19 with positive PCR test 22 days before. A histology of the placenta showed deposition of intervillous fibrinoid, lympho-histiocytic infiltration, scant neutrophils, clumping of villi, and extant infarctions. Immunohistochemistry identified focal SARS-CoV-2 nucleocapsid and spike protein in the syncy

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Fuchs, Ota. "Treatment of Lymphoid and Myeloid Malignancies by Immunomodulatory Drugs." Cardiovascular & Hematological Disorders-Drug Targets 19, no. 1 (2019): 51–78. http://dx.doi.org/10.2174/1871529x18666180522073855.

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Thalidomide and its derivatives (lenalidomide, pomalidomide, avadomide, iberdomide hydrochoride, CC-885 and CC-90009) form the family of immunomodulatory drugs (IMiDs). Lenalidomide (CC5013, Revlimid®) was approved by the US FDA and the EMA for the treatment of multiple myeloma (MM) patients, low or intermediate-1 risk transfusion-dependent myelodysplastic syndrome (MDS) with chromosome 5q deletion [del(5q)] and relapsed and/or refractory mantle cell lymphoma following bortezomib. Lenalidomide has also been studied in clinical trials and has shown promising activity in chronic lymphocytic leuk

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Zarubin, Aleksei, Vadim Stepanov, Anton Markov, et al. "Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy." Genes 12, no. 1 (2020): 19. http://dx.doi.org/10.3390/genes12010019.

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The human serine protease serine 2 TMPRSS2 is involved in the priming of proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and represents a possible target for COVID-19 therapy. The TMPRSS2 gene may be co-expressed with SARS-CoV-2 cell receptor genes angiotensin-converting enzyme 2 (ACE2) and Basigin (BSG), but only TMPRSS2 demonstrates tissue-specific expression in alveolar cells according to single-cell RNA sequencing data. Our analysis of the structural variability of the TMPRSS2 gene based on genome-wide data from 76 human populations demonstrates that a function

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Kurosawa, Ryo, Kimio Satoh, Takashi Nakata, et al. "Identification of Celastrol as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A)." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 3 (2021): 1205–17. http://dx.doi.org/10.1161/atvbaha.120.315731.

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Objective: Pulmonary arterial hypertension is characterized by abnormal proliferation of pulmonary artery smooth muscle cells and vascular remodeling, which leads to right ventricular (RV) failure. Bsg (Basigin) is a transmembrane glycoprotein that promotes myofibroblast differentiation, cell proliferation, and matrix metalloproteinase activation. CyPA (cyclophilin A) binds to its receptor Bsg and promotes pulmonary artery smooth muscle cell proliferation and inflammatory cell recruitment. We previously reported that Bsg promotes cardiac fibrosis and failure in the left ventricle in response t

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Drach, Johannes, Astrid Slany, Verena Sagaster, et al. "A Cellular Proteome Map of Human Multiple Myeloma." Blood 110, no. 11 (2007): 111. http://dx.doi.org/10.1182/blood.v110.11.111.111.

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Abstract Background and Aims: Molecular profiling identifies proteins characteristically deregulated in malignant diseases. Characteristic biomarkers may be useful to support diagnosis and patient stratification, while the recognition of aberrant cell activities and cell survival strategies may lead to the development of specifically designed pharmacologic strategies. We therefore performed proteomic profiling of primary human multiple myeloma (MM) cells in order to define the impact of protein expression abnormalities in MM. Methods: Plasma cells were isolated from bone marrow of patients wit

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Guda, Maheedhara R., Andrew J. Tsung, Swapna Asuthkar, and Kiran Velpula. "Abstract 4465: Galectin-1 regulates CD147 and downstream pathways critical for glioma progression." Cancer Research 84, no. 6_Supplement (2024): 4465. http://dx.doi.org/10.1158/1538-7445.am2024-4465.

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Abstract Galectin-1 (Gal-1) is an important protein for glioma progression and glioma stem cell maintenance. Gal-1 may act through CD147, a potential Gal-1 receptor. CD147, also known as Basigin or extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein highly expressed in various cancer cells. An analysis utilizing the Gliovis database and encompassing 667 Glioblastoma Multiforme (GBM) patients segregated based on median CD147 expression levels delineated cohorts with above-median (n=339) and below-median (n=328) CD147 expression. Kaplan-Meier survival curves

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Pons, Marianne, Scott W. Cousins, Oscar Alcazar, Gary E. Striker, and Maria E. Marin-Castaño. "Angiotensin II–Induced MMP-2 Activity and MMP-14 and Basigin Protein Expression Are Mediated via the Angiotensin II Receptor Type 1–Mitogen-Activated Protein Kinase 1 Pathway in Retinal Pigment Epithelium." American Journal of Pathology 178, no. 6 (2011): 2665–81. http://dx.doi.org/10.1016/j.ajpath.2011.02.006.

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De Back, Djuna Zoe, Elena Kostova, Thomas Klei, et al. "RBC Adhesive Capacity Is Essential for Efficient 'Immune Adherence Clearance' and Provide a Generic Target to Deplete Pathogens from Septic Patients." Blood 128, no. 22 (2016): 1031. http://dx.doi.org/10.1182/blood.v128.22.1031.1031.

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Abstract Sepsis is a life threatening organ dysfunction caused by a dysregulated host response to infection. It is a global health care problem and the leading cause of death in ICU patients. A rather unknown but effective mechanism to protect ourselves from such pathogen invasion is immune-adherence clearance (IAC). During IAC pathogens (including bacteria, fungi and viruses) can bind to red blood cells (RBCs) through complement opsonization and subsequent binding to complement receptor 1 (CR1, CD35) expressed on their cell surface. After binding of the pathogen to CR1, the RBCs deliver the p

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Fenizia, Claudio, Silvia Galbiati, Claudia Vanetti, et al. "SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2." Cells 10, no. 6 (2021): 1434. http://dx.doi.org/10.3390/cells10061434.

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In late 2019, the betacoronavirus SARS-CoV-2 was identified as the viral agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. Coronaviruses Spike proteins are responsible for their ability to interact with host membrane receptors and different proteins have been identified as SARS-CoV-2 interactors, among which Angiotensin-converting enzyme 2 (ACE2), and Basigin2/EMMPRIN/CD147 (CD147). CD147 plays an important role in human immunodeficiency virus type 1, hepatitis C virus, hepatitis B virus, Kaposi’s sarcoma-associated herpesvirus, and severe acute respiratory syndrome coron

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Laurenson, Alexander J., Emily Stucke, Ryan Scalsky, and Matthew B. Laurens. "In Silico Prediction of Plasmodium falciparum PfRipr Epitopes as Vaccine Candidates." Journal of the Pediatric Infectious Diseases Society 12, Supplement_1 (2023): S5—S6. http://dx.doi.org/10.1093/jpids/piad070.012.

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Abstract Background The global malarial death toll in 2020 was ~627,000, 77% of which occurred in children &lt;5 years of age. Plasmodium falciparum is the most lethal parasite of its genus but has evaded vaccine development due to its complex life cycle and redundant invasion mechanisms. Epitope-based vaccines hold significant promise due to their ability to target dominant and/or conserved regions in highly antigenically variable pathogens, including malaria. The recently characterized P. falciparum merozoite Rh5 interacting protein (PfRipr) is nonredundant, highly conserved, and essenti

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Kallumadyil, Andrea M. T., Tess McClenahan, Samantha De Filippis, et al. "Perspectives into the possible effects of the B.1.1.7 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on spermatogenesis." Journal of Basic and Clinical Physiology and Pharmacology 33, no. 1 (2021): 9–12. http://dx.doi.org/10.1515/jbcpp-2021-0083.

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Abstract B.1.1.7 is a recently discovered variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated with increased transmissibility. Recent findings indicate that this variant has a propensity to infect adolescents and children at higher rates than adults. The virus gains entry into various body cells utilizing angiotensin-converting enzyme 2 (ACE-2) and basigin (CD147) as receptors. The virus mainly affects type II pneumocytes of lungs, endothelial cells, enterocytes, and renal tubular cells. It is reported to affect testes, causing testicular pain, and producing hist

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Toyama, Hiroshi, Masanori Ichise, James R. Ballinger, Luis Fornazzari, and Joel C. Kirsh. "Dopamine D2 receptor SPECT imaging: Basicin vivo characteristics and clinical applications of123I-IBZM in humans." Annals of Nuclear Medicine 7, no. 1 (1993): 29–38. http://dx.doi.org/10.1007/bf03164789.

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Hart, Edilberto, and Carlos Ramos. "Niñez: instrumento para la salvaguardia de la cultura de San Basilio de Palenque." Revista Arbitrada Interdisciplinaria Koinonía 4, no. 8 (2019): 288. http://dx.doi.org/10.35381/r.k.v4i8.278.

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Recibido: 19 de marzo del 2019Aprobado: 01 de mayo del 2019El trabajo es un estudio analítico bibliográfico, tiene como objetivo analizar laniñez como instrumento para la salvaguardia de la cultura de San Basilio de Palenque. En este sentido, la cultura influye de manera importante en cualquier persona, pero más en el niño puesto que es el receptor de la información a su alrededor, el va siendo moldeado por una sociedad, familia o demás personas que lo acompañan en su proceso de crianza, también las escuelas han contribuido desde la infancia a la edificación del espíritu de reflexión sobre lo

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Sauer, H., J. Hescheler, and M. Wartenberg. "Mechanical strain-induced Ca2+waves are propagated via ATP release and purinergic receptor activation." American Journal of Physiology-Cell Physiology 279, no. 2 (2000): C295—C307. http://dx.doi.org/10.1152/ajpcell.2000.279.2.c295.

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Mechanical strain applied to prostate cancer cells induced an intracellular Ca2+ (Cai 2+) wave spreading with a velocity of 15 μm/s. Cai 2+ waves were not dependent on extracellular Ca2+ and membrane potential because propagation was unaffected in high-K+ and Ca2+-free solution. Waves did not depend on the cytoskeleton or gap junctions because cytochalasin B and nocodazole, which disrupt microfilaments and microtubules, respectively, and 1-heptanol, which uncouples gap junctions, were without effects. Fluorescence recovery after photobleaching experiments revealed an absence of gap junctional

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Castillo Bohórquez MSC, Martha, Ana Isabel Mora Bautista MSC, Katherine Layton Donato, Francy Pérez Llanos, and Milena Tapiero Rodríguez. "Identificación de sujetos a riesgo de deficiencia de hierromediante el Indicé Receptor Soluble de Transferrina-Log Ferritina sérica en hombres afrodescendientes residentes en San Basilio de Palenque y Cartagena de Indias, DTyC., Bolívar, Colombia." Nova 8, no. 13 (2010): 54. http://dx.doi.org/10.22490/24629448.439.

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En el ámbito mundial, sin distingo de raza, edad, género ni procedencia geográfica, la anemia de mayor prevalencia es la anemia ferropénica. De la misma forma, son insuficientes los reportes nacionales e internacionales sobre la prevalencia de los estados subclínicos de hierro, especialmente en comunidad afrodescendiente. El objetivo de la investigación fue caracterizar una población masculina afrodescendiente de 73 hombres sanos con edades comprendidas entre los 16 y 30 años mediante el comportamiento del índice (sTfR- Log F.S.), residentes en San Basilio de Palenque y en Cartagena de Indias

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Cavaliere, Fabio, Nadia D'Ambrosi, Giuseppe Sancesario, Giorgio Bernardi, and Cinzia Volonté. "Hypoglycaemia-induced cell death: features of neuroprotection by the P2 receptor antagonist basilen blue." Neurochemistry International 38, no. 3 (2001): 199–207. http://dx.doi.org/10.1016/s0197-0186(00)00087-5.

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Luquetta Cediel, David Jerónimo, Claudia Beltrán Romero, Marta Romero Moreno, and Luis Ricardo Navarro Díaz. "Dispositivos culturales. Mecanismos de sociabilidad en contextos de conflicto armado." Teuken Bidikay - Revista Latinoamericana de Investigación en Organizaciones, Ambiente y Sociedad 10, no. 15 (2019): 99–112. http://dx.doi.org/10.33571/teuken.v10n15a4.

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Este texto hace parte del desarrollo del proyecto de investigación titulado Procesos de memoria histórica y prácticas comunicativas en la vereda La Bonga-Bolívar, en el cual se buscan identificar los dispositivos culturales potencialmente valiosos para mediar en los conflictos entre comunidades. El proyecto se centra en la relación entre la población de San Basilio de Palenque, en su papel de población receptora, y la comunidad desplazada de la vereda La Bonga, en el departamento de Bolívar, Colombia. Nos referimos a un desplazamiento ocurrido en abril de 2001, cuando fueron objetivo de amenaz

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Kanjee, Usheer, Christof Grüring, Mudit Chaand, et al. "CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants ofPlasmodium falciparuminvasion." Proceedings of the National Academy of Sciences 114, no. 44 (2017): E9356—E9365. http://dx.doi.org/10.1073/pnas.1711310114.

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During malaria blood-stage infections,Plasmodiumparasites interact with the RBC surface to enable invasion followed by intracellular proliferation. Critical factors involved in invasion have been identified using biochemical and genetic approaches including specific knockdowns of genes of interest from primary CD34+hematopoietic stem cells (cRBCs). Here we report the development of a robust in vitro culture system to produce RBCs that allow the generation of gene knockouts via CRISPR/Cas9 using the immortal JK-1 erythroleukemia line. JK-1 cells spontaneously differentiate, generating cells at

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Li, Shoujian, Youyan Liu, Liu Liu, Bing Li, and Shunxing Guo. "Genome Sequencing Providing Molecular Evidence of Tetrapolar Mating System and Heterothallic Life Cycle for Edible and Medicinal Mushroom Polyporus umbellatus Fr." Journal of Fungi 11, no. 1 (2024): 15. https://doi.org/10.3390/jof11010015.

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Polyporus umbellatus is a species whose sclerotia have been extensively employed in traditional Chinese medicine, which has diuretic, antitumor, anticancer, and immune system enhancement properties. However, prolonged asexual reproduction has resulted in significant homogenization and degeneration of seed sclerotia. In contrast, sexual reproduction has emerged as an effective strategy to address these challenges, with a distinct mating system serving as the foundation for the implementation of sexual breeding. This study presents the first sequencing and assembly of the genome of P. umbellatus

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Sherman, Deb S., Carrie L. Kass, and Douglas N. Fish. "Fludrocortisone for the Treatment of Heparin-Induced Hyperkalemia." Annals of Pharmacotherapy 34, no. 5 (2000): 606–10. http://dx.doi.org/10.1345/aph.19326.

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OBJECTIVE: To report the use of fludrocortisone for heparin-induced hyperkalemia and to briefly review the available literature relating to heparin-induced hyperkalemia. CASE SUMMARY: A 34-year-old African-American man was admitted to the hospital for pneumococcal pneumonia and sepsis. His hospital course was complicated by the development of acute respiratory distress syndrome, severe sepsis, acute renal failure, placement of a tracheostomy, and recurrent nasopharyngeal bleeding. The patient also developed a subclavian vein thrombosis with extension to the cephalic and basilic veins secondary

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Ayala, Diego, Silvia Ayala, Guillermo Pabón, and Jonathann Fabara. "Análisis y selección de un pozo reinyector en la Cuenca Oriente." Revista Fuentes el Reventón Energético 18, no. 1 (2020): 51–59. http://dx.doi.org/10.18273/revfue.v18n1-2020006.

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La demanda del crudo ha crecido de manera constante incrementando el número de pozos perforados para mantener la producción, pero el crudo viene con un agua fósil, este es un problema que el área de producción se toma muy en serio. La cantidad de agua es proporcional al número de pozos perforados y su aumento es intrínseco a la tasa de producción, lo cual además viene asociado a la madurez de cada pozo, esta situación supone un verdadero reto a la hora de gestionar este residuo que debido a su composición se direcciona en dos frentes, el primero como mecanismo de apoyo en recuperación de crudo

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Shilts, Jarrod, Thomas W. M. Crozier, Edward J. D. Greenwood, Paul J. Lehner, and Gavin J. Wright. "No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-80464-1.

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AbstractThe spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147. These early studies have already prompted a clinical trial and multiple published hypotheses speculating on the role of this host receptor in viral infection and pathogenesis. Here, we report that we are unable to find evidence supporting the role of basigin as a putative spike binding receptor. Recombinant forms of the SARS-CoV-2 spike do not interact with basigin

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Juresic, Sanny, and Judith D. Ochrietor. "Analysis of immune molecule expression in mouse adipose tissue and deep fat." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.627.9.

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Many recent studies indicate that adipose tissue plays a role in innate immunity and inflammation. This lab has been studying the expression of Basigin gene products and the innate immune receptor TLR4 with respect to neural immune functions. Basigin gene products are members of the immunoglobulin superfamily. In the neural retina, Basigin forms a transport metabolon with monocarboxylate transporter 1 (MCT1), which is vital for the function of photoreceptor neurons in mice. Basigin is also expressed on monocytes and epithelial cells throughout the body, but has been less studied in connective

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Nasuhidehnavi, Azadeh, Yanlin Zhao, Ankita Punetha, et al. "A Role for Basigin in Toxoplasma gondii Infection." Infection and Immunity, August 2022. http://dx.doi.org/10.1128/iai.00205-22.

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The role of specific host cell surface receptors during Toxoplasma gondii invasion of host cells is poorly defined. Here, we interrogated the role of the well-known malarial invasion receptor, basigin, in T. gondii infection of astrocytes.

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Jamwal, Abhishek, Cristina F. Constantin, Stephan Hirshi, et al. "Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes." eLife 12 (October 5, 2023). http://dx.doi.org/10.7554/elife.83681.

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Basigin is an essential host receptor for invasion of Plasmodium falciparum into human erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage malaria vaccine candidate and a target of growth-inhibitory antibodies. Here we show that erythrocyte basigin is exclusively found in one of two macromolecular complexes, bound either to plasma membrane Ca2+-ATPase 1/4 (PMCA1/4) or to monocarboxylate transporter 1 (MCT1). PfRH5 binds to each of these complexes with a higher affinity than to isolated basigin ectodomain, making it likely that these are the physiologic

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