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Rozprawy doktorskie na temat „BCL7”

Autor: Grafiati

Data publikacji: 21 grudnia 2024

Data aktualizacji: 31 lipca 2025

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1

Martin, Franck. "Structural and functional studies of chromatin remodeling complex mamalian SWI / SNF." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ044.

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La chromatine est une structure dynamique régulée par différents mécanismes épigénétiques parmi lesquels le remodelage de la chromatine dépendant de l’ATP comme le SWI/SNF. Leur importance est telle que les mutations des protéines de remodelage de la chromatine sont fortement associées à plusieurs maladies dont le cancer. Par exemple les protéines BCL7, qui sont de nouvelles sous unité centrales récemment identifié du complexe SWI/SNF des mammifère, sont associées à différents types de cancers comme dans le Diffuse Large B-cell Lymphoma (DLBCL). Les informations sur les protéines BCL7 sont à c

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Barrans, Sharon Louise. "Immunophenotypic and molecular approaches to the classification of diffuse large B cell lymphoma." Thesis, Manchester Metropolitan University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366169.

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3

Li, Yue. "Investigating Selected Mechanisms of Modulation of BECN1-mediated Autophagy." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29775.

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Autophagy is a lysosomal degradation pathway wherein cytoplasmic components not needed by or harmful to the cell are degraded and recycled. BECN homologs are key autophagy proteins consisting of an intrinsically disordered region (IDR), flexible helical domain (FHD), coiled-coil domain (CCD) and β-α repeated, autophagy-specific domain (BARAD). Diverse proteins modulate autophagy by binding BECN1. Understanding the mechanisms by which these proteins regulate BECN1-mediated autophagy is important for developing therapeutics targeting these proteins. Toward this goal, we have developed purificati

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4

Thompson, Brian M. "Amino-terminal sequences of the bacillus anthracis exosporium proteins BCLA and BCLB important for localization and attachment to the spore surface." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/5700.

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Thesis (M.S.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "August 2008" Includes bibliographical references.

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Kunze, Doreen. "Small interfering RNA-vermittelte Hemmung der Apoptoseinhibitoren BCL2, BCL-XL, XIAP und Survivin in Zellkultur- und Mausmodellen des humanen Harnblasenkarzinoms." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-81888.

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Das Harnblasenkarzinom (BCa) stellt in Deutschland die vierthäufigste Tumorneuerkrankung und die zehnthäufigste krebsbedingte Todesursache bei Männern dar. Nichtmuskelinvasive BCa werden organerhaltend aus der Blasenwand entfernt und zur Rezidiv- und Progressionsprophylaxe mittels intravesikaler Chemo- oder Immuntherapien behandelt. Trotz dieser adjuvanten Therapien, die mit starken Nebenwirkungen verbunden sein können, ist nur eine bedingte Minimierung des Rezidivrisikos möglich. Besonders im fortgeschrittenen Stadium weisen Harnblasenkarzinome eine schlechte Prognose auf. Obwohl das BCa eine

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6

Mahn, Friederike Marie [Verfasser]. "Bruchereignisse in den Onkogenorten BCL2, BCL6 und MYC bei aggressiven B-Zell-Lymphomen im Kindesalter : molekularzytogenetische Analysen im Rahmen der NHL-BFM-Studie / Friederike Maria Mahn." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/101998337X/34.

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7

Viant, Charlotte. "Régulation du développement et de la fonction des cellules innées lymphoïdes NKp46+." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4018/document.

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Il existe différents groupes de cellules lymphoïdes innées (ILC) qui ont été caractérisées en fonction des facteurs de transcriptions indispensables à leur différenciation et des cytokines qu’elles sécrètent. Les ILC1, dont font partie les cellules Natural Killer (NK), expriment T-bet et produisent de l’IFN-γ. Les ILC2 sont caractérisées par GATA-3 et sécrètent de l’IL-5 et de l’IL-13. Quant aux ILC3, elles ont été identifiées par leur sécrétion d’IL-17 et d’IL-22 ainsi que par l’expression de RORγt.Mon travail de thèse m’a amené à étudier différents aspects de la biologie des cellules NK et I

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8

Hakert, James Damian. "The crosstalk between notch1 and BCL6." Tallahassee, Fla. : Florida State University, 2010. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/2181936.

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Thesis (Honors paper)--Florida State University, 2010.<br>Advisor: Dr. Yoichi Kato, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Includes bibliographical references.

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9

Warner, Andrew. "Borylative cyclisation of alkynes using BCl3." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/borylative-cyclisation-of-alkynes-using-bcl3(7a4e56f3-e8c6-4c68-97ec-4596ef5e0ce2).html.

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Boron trichloride, a cheap and commercially available Lewis acid, has been demonstrated to activate alkynes possessing appropriate nucleophiles, facilitating borylative cyclisation. This reaction furnishes polycyclic compounds possessing a new C(sp2)-B bond externally to the newly formed ring (through concomitant C-C and C-B bond formation). The RBCl2 intermediates generated from cyclisation were esterified with pinacol to furnish air/moisture stable boronic esters. This methodology has been applied to the following classes of starting materials: 1,4-disubstituted but-1-ynes (including N- and

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10

Leal, Cristina Tavares. "Identificação da família BCL2 como alvo terapêutico no tratamento das neoplasias mieloproliferativas associadas à mutação da JAK2V617F." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17154/tde-06042018-114114/.

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As neoplasias mieloproliferativas (NMPs) negativas para o rearranjo t(9;22)/BCRABL1, incluindo Policitemia Vera (PV), Trombocitemia Essencial (TE) e Mielofibrose Primária (MFP), são doenças hematopoéticas clonais e estão frequentemente associadas à mutação JAK2V617F. Apesar dos avanços no conhecimento da fisiopatologia após a descoberta da mutação JAK2V617F e do desenvolvimento de inibidores da JAK2, o tratamento permanece não curativo. Sabe-se que as célulastronco mais primitivas nas NMPs são responsáveis pela iniciação da doença e que a expansão dos precursores mieloeritróides contribui para

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11

Kurata, Masayuki. "Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6." Kyoto University, 2003. http://hdl.handle.net/2433/149369.

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12

Xavier, Flavia Dias. "Padrão de expressão e significado prognóstico dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 pela técnica de PCR em tempo real com linfoma difuso de grandes células B tratado com rituximabe." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-24062013-114437/.

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Introdução: O linfoma difuso de grandes células B é o mais freqüente grupo de linfoma não- Hodgkin, perfazendo quase 50% dos casos no serviço de hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e Instituto do Câncer do Estado de São Paulo. Possui heterogeneidade clínica e biológica traduzida em mais de vinte subtipos na Organização Mundial da Saúde. Sua terapêutica se baseia na associação do anticorpo monoclonal anti-CD20 e quimioterapia com antracíclico, esquema que resulta em 43,5% de sobrevida global em 10 anos. Determinantes de prognóstico clínico

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13

Ng, Florence Wai Hung. "Identification and characterization of Bcl-2/Bcl-X¦L interacting protein, p28Bap31." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0015/NQ44531.pdf.

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14

Piedfer, Marion. "Identification de nouvelles cibles pro-apoptotiques dans les leucémies aiguës myéloblastiques." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00781221.

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Les leucémies aiguës myéloblastiques (LAM) sont des maladies hématopoïétiques caractérisées par une prolifération incontrôlée de précurseurs myéloïdes bloqués à divers stades de différenciation. Le pronostic des LAM reste sombre à cause de la résistance aux traitements et des rechutes après rémission. En conséquence, des thérapies moins intensives et mieux tolérées doivent être développées ; ceci nécessite le développement de stratégies combinatoires associant des molécules avec des modes d'action différents pour augmenter l'efficacité des traitements. Plusieurs approches sont en cours d'étude

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15

Szostek, Joanna M. "Russia in the news of its neighbours : cross border media influence in Ukraine and Belarus." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:ae3ece7b-32ad-41e5-bce7-5f7ddeb28490.

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This thesis investigates the nature and impact of Russian influence on Russian-language print and broadcast news in Ukraine and Belarus. TV channels and publications with shareholders or partners in Russia are widely available in both the countries studied; existing literature suggests that such ‘Russian’ media are a source of regional power for the Kremlin. To shed light on how Russian partners and shareholders affect editorial treatment of Russia, the thesis compares content samples from 27 TV news bulletins and newspapers available in Ukraine or Belarus, some of which have Russian partners

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Charlton, Andrew. "Towards the development of direct methodology to enantioenriched α-alkylated aldehydes". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:bcfe43bb-1497-4f94-bcc7-6f7c2ae0b3a1.

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Enantiopure α-alkyl-substituted aldehydes are widely recognised as important building blocks in synthesis. Despite this, methods to prepare such substrates are limited. Strategically, asymmetric intermolecular S<sub>N</sub>2 α-alkylation represents a highly straightforward transformation, but still remains an elusive feat. This thesis describes efforts to address this challenge, with attempted access to enantioenriched α-alkyl aldehydes by way of C-alkylation of chiral, non-racemic, hindered aldenamines using simple alkyl halides. Enamines derived from four types of auxiliary (a tropane, an ox

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17

Pitidol, Thorn. "The limits of community participation : examining the roles of discourse, institutions, and agency in the promotion of community participation in Thailand." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c6588478-750c-4d54-bc57-7b06ef220f7a.

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This thesis is a study of how community participation is understood, enacted, produced and governed in the context of an organization that promotes community participation. The contribution of this thesis is to shed light on the frequently found gap between the expectations and the reality of community participation. In examining how community participation is promoted, the thesis focuses in particular on actors such as community leaders and development workers, and the interactions between them. The thesis applies a multi-disciplinary theoretical framework, which is built through combining th

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18

Linguraru, Marius George. "Feature detection in mammographic image analysis." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:b92185f0-c7bf-40e1-bc17-bf71065f001f.

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In modern society, cancer has become one of the most terrifying diseases because of its high and increasing death rate. The disease's deep impact demands extensive research to detect and eradicate it in all its forms. Breast cancer is one of the most common forms of cancer, and approximately one in nine women in the Western world will develop it over the course of their lives. Screening programmes have been shown to reduce the mortality rate, but they introduce an enormous amount of information that must be processed by radiologists on a daily basis. Computer Aided Diagnosis (CAD) systems aim

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19

Choi, Yoonjoo. "Protein loop structure prediction." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:bd5c1b9b-89ba-4225-bc17-85d3f5067e58.

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This dissertation concerns the study and prediction of loops in protein structures. Proteins perform crucial functions in living organisms. Despite their importance, we are currently unable to predict their three dimensional structure accurately. Loops are segments that connect regular secondary structures of proteins. They tend to be located on the surface of proteins and often interact with other biological agents. As loops are generally subject to more frequent mutations than the rest of the protein, their sequences and structural conformations can vary significantly even within the same pr

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20

Meyer, Thomas George. "Global human rights and contextualised civic learning : a case study of human rights education in Japan." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:f073a51d-20b8-4610-bc37-84370d4700a5.

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While global human rights knowledge has become a central facet of curricula used to shape multicultural societies and develop cosmopolitan citizenry, such knowledge is shaped by sociopolitical context. Japan has a long history of incorporating human rights concepts into its citizenship curriculum; however, this curriculum is produced in a political context where there is resistance to extending rights to minorities and the disadvantaged, and where there are renewed attempts to emphasise traditional Japanese cultural values through education. Potential tensions have been recognised, yet little

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O'Loughlin, Aisling. "Towards extracellular vesicle based gene therapy for Huntington's disease." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d44d4535-aeb2-4bc0-bc27-15ce9ef4e37e.

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Huntington's disease (HD) can be regarded as a model neurodegenerative disorder to screen potential genetic based therapeutics and their carriers. It is an autosomal dominant disorder caused by a mutation in a single gene that leads to progressive neurodegeneration caused in part by protein misfolding. The mutation codes for an expanded polyglutamine tract within the Huntingtin gene (HTT) which leads to neuronal loss through a pathological cascade of events. Current treatment strategies include symptom management but no disease-modifying therapies exist. Research has shown that nucleic acid ba

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Laghezza, Gianluca. "Lattice Boltzmann study of evaporation phenomena." Thesis, University of Oxford, 2016. http://ora.ox.ac.uk/objects/uuid:ddab7a63-09d8-4fa7-bc87-577be6333091.

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Evaporation phenomena are having a resurgent interest in the recent years thanks to new techniques that allow for better flow visualization and microfabrication techniques of surfaces with interesting wetting properties. From the theoretical point of view the development of simulation techniques for evaporation phenomena is a challenging work due to the presence of moving interfaces and multiphase flows. Thanks to its mesoscopic nature, the Lattice Boltzmann method is an ideal candidate for the simulation of evaporation phenomena. Here we present a Lattice Boltzmann algorithm capable to correc

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23

Abed, Shahla. "Läkemedel mot Bcl-2 överuttryckande resistenta Prostatatumörer : Läkemedel mot Bcl-2 överuttryckande resistenta Prostatatumörer." Thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106293.

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Barrezueta, Luis Fernando Mesias [UNIFESP]. "Imuno-expressão das proteínas da família BCL-2 (BCL-2. BCL-XL, BAX, BAK, BAD) em câncer gátrico, preparados em arranjo em matriz (TMA)." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9724.

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Made available in DSpace on 2015-07-22T20:50:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-01-28<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Em casos de carcinoma gástrico, para contribuir ao conhecimento do processo de carcinogênese: Objetivo: Estudar a expressão das proteínas da família Bcl-2 (BcI-2, Bcl-xl, Bak, Bad, Bax). Correlacionar a expressão destas proteínas com 0 índice apoptótico mediante a expressão da proteína Caspase 3 clivada, com 0 índice mit6tico mediante a expressão

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Bah, Nourdine. "Contrôle du déclenchement de l'apoptose pendant l'arrêt mitotique par l'homologue de Bcl-2, Bcl-xL." Nantes, 2013. http://archive.bu.univ-nantes.fr/pollux/show.action?id=d6222d04-bb86-43e6-810b-21a673a07295.

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Les poisons des microtubules, comme le paclitaxel, sont des composés qui modifient la dynamique des microtubules, et bloquent les cellules en mitose par non-satisfaction du point de contrôle mitotique. La principale cible du point de contrôle mitotique est l'APC/C, une ligase E3 qui régule la dégradation de protéines importantes pour la progression de la mitose. Un de ces substrats est la cycline BI, le cofacteur essentiel à l'activité de Cdk1 , et par conséquent essentiel pour le maintien de la mitose. Sous paclitaxel, le point de contrôle mitotique est actif, et cela aboutit à un blocage en

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Pécot, Jessie. "Dépendance des cellules cancéreuses à BCL-xL : ciblage thérapeutique du réseau d'interactions PUMA, BAX et BCL-xL : effets oncogéniques non canoniques de l'interaction RAS / BCL-xL." Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=57dfe09c-18e6-4d60-a1e1-cbc567f5cda6.

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La protéine BCL-xL fréquemment surexprimée dans les cancers est impliquée dans la résistance aux chimiothérapies. De nouvelles molécules ciblant cette protéine ont ainsi été développées. Le travail présenté dans le cadre de cette thèse montre que, malgré une spécificité de plus en plus grande de ces molécules, elles restent inefficaces à antagoniser certaines interactions impliquant BCL-xL. Ainsi un traitement au WEHI-539 (ciblant spécifiquement BCL-xL) ne sensibilise pas des cellules surexprimant BCL-xL à une mort dépendante de PUMA, une protéine interagissant avec BCL-xL qui joue un rôle ess

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Dawes, Joanna Camilla. "Modelling Crebbp loss in BCL2 driven non-Hodgkin's lymphoma." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58194.

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Non-Hodgkin’s lymphomas (NHL) are a spectrum of hematopoietic cancer accounting for 4% of new cancer diagnoses each year. Approximately 95% of all NHL are of B-cell origin; diffuse large B-cell lymphomas (DLBCL) and follicular lymphoma (FL) accounting for 30-40% and 20% of B-NHL respectively. Recent human mutation profiling and resequencing studies have shown that CREBBP and BCL2 are frequently mutated, early events in B-NHL that are often are concurrent. This thesis presents a study of their role in oncogenesis by generating a novel model of B-NHL overexpressing BCL2 in the haematopoetic comp

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Webster, Philip. "The genetics and kinetics of BCL2 driven lymphoid malignancies." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/45406.

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Introduction: Non-Hodgkin Lymphoma (NHL) is rising in incidence. Treatment of this genetically heterogeneous disease has toxic side effects and significant numbers of relapsers / non-responders. BCL2, an anti-apoptotic protein, is commonly overexpressed in NHL as a result of the t(14;18) translocation. A number of BCL2 inhibitors have shown success in clinical trials but variable efficacy has meant that none have been licenced for use. Methods: Retroviral insertional mutagenesis (RIM), using Moloney Murine Leukaemia Virus (MoMuLV) in transgenic mice overexpressing BCL2, was used to identify pu

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Приступа, Людмила Никодимівна, Людмила Никодимовна Приступа, Liudmyla Nykodymivna Prystupa та ін. "Bcl1 поліморфізм як одна із генетичних детермінант нікотинової залежності". Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35697.

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Згідно останніх даних куріння є причиною смерті близько п'яти мільйонів людей щороку, оскільки збільшує ризик розвитку багатьох захворювань, у першу чергу – легень і серцево-судинної системи, а також – онкопаталогії. Давно відомо щодо стимулюючого впливу ряду факторів зовнішнього середовища на формування даної пагубної звички. Тим не менш, в останні роки, з’являється велика кількість досліджень щодо ролі генетичних факторів у розвитку нікотинової залежності. Система досліджень у популяціях близнюків та окремих сімей показала, що існує не один конкретний ген, який визначає розвиток схильності

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Rabbitte, Deirdre. "The translational control of Bcl-2." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430650.

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Fukuda, Nobutaka. "Fertility decline in Japan since the 1970s : socio-ecomic factors or attitudinal factors?" Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:8303e991-71bf-4198-bc87-d2090c0415d6.

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This study investigates the influence of socio-economic and attitudinal factors on recent changes in marriage and fertility in Japan. Using macroand micro-data (collected especially for this research), the study examines the validity of three main theories: (1) the New Home Economics theory; (2) Easterlin's theory; and (3) the ideational (or attitudinal) theory in detemining Japanese marriage and fertility behaviour. The findings of this study show that socio-economic factors exert a substantial effect on Japanese marriage and fertility behaviour. More specifically, an increase in women's earn

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Keykhah, Mojdeh. "The shape of uncertainty : insurance underwriting in the face of catastrophe." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:850ace8c-da6d-4c9a-bce7-8f7495ba7357.

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In this thesis I study the nature of decision making under uncertainty in the case of natural catastrophes and reinsurance underwriting at Lloyd's of London. I begin by describing the broad context of natural catastrophes and society, which forms the basis for a market in catastrophe reinsurance. I then proceed to a review of literatures in risk, uncertainty, philosophy, and probability as a prelude to an analysis of decision making under catastrophic risk. According to the early 20th century philosopher-economist Frank Knight, risk specified those cases in which a frequency probability could

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Paddon, Emily. "Taking sides : impartiality, norm contestation and the politics of UN peacekeeping." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:1dda63f4-5e19-4c98-bc57-3d0902dd80f6.

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Impartiality has long been a core norm of United Nations peacekeeping. However, since 2000 the dominant conception of impartiality has changed, leading to more coercive forms of peacekeeping. Claims to impartial authority are no longer based exclusively on terms to which all parties consent. Instead, they are premised on a more ambitious and expansive set of norms related to human rights, around which consensus is presumed but not always affirmed. This dissertation critically examines the change in both the conception and practice of impartiality, which, it argues, is an integral part of the e

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Messenger, Gregory. "The development of WTO law in light of transnational influences : the merits of a causal approach." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:2b2214c2-6e83-44cd-bc07-bd0bf2999dc8.

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The WTO is one piece in a complex network of international, regional and domestic legal systems and regulatory frameworks. The influences on the development of WTO law extend far beyond its own Members and institutions: domestic legal instruments have provided the inspiration for numerous WTO obligations while the rights and obligations under the covered agreements are frequently incorporated into the legal systems of the Membership. The WTO is home to numerous committees and working groups that also engage with other international bodies and their domestic counterparts. Transnational actors s

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Drenas, Andrew J. G. "'The Standard-bearer of the Roman Church' : Lorenzo da Brindisi (1559-1619) and Capuchin Missions in the Holy Roman Empire." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:74703f2b-5da1-4a5c-bc77-923f006781f3.

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This thesis examines the missionary work of the Italian Capuchin Lorenzo da Brindisi. Renowned in his own day as a preacher, Bible scholar, missionary, chaplain, and diplomat, as well as vicar general of his Order, Lorenzo led the first organised, papally-commissioned Capuchin mission among the non-Catholics of Bohemia in the Holy Roman Empire from 1599 to 1602, and returned there, again under papal mandate, from 1606 to 1613. This thesis examines Lorenzo’s evangelistic and polemical activities in Central Europe in order to shed light on some of the ways the Capuchins laboured in religiously d

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Johnston, Jean-Michel. "The moods of modernity : Germany in the age of telegraphy, c.1830-c.1880." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:2054eff2-ca29-4326-bc27-a79396f6de6a.

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This thesis investigates the origins and impact of electrical telegraphy in Germany between 1830 and 1880, situating them within the context of long-term transformations in the theory and practice of communication. It uses the development of telegraphy as an analytical lens through which to explore the connections between actors at the heart of the socio-economic transformations taking place in Germany during the period. Both as an innovation and as a tool of communication, this thesis argues, the telegraph epitomised the simultaneously growing interdependence and differentiation between peopl

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Mohran, Hossnia Saber. "Analytical and thermodynamic studies on some halogenated benzenoid compounds." Thesis, Royal Holloway, University of London, 1986. http://repository.royalholloway.ac.uk/items/6eed7444-a22e-47ac-bcc7-850e50d14fbb/1/.

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The bromination of 2-fluorophenol, 3-fluorophenol, 4-fluorophenol, 2-fluoroaniline, 3-fluoroaniline and 4-fluoroaniline was carried out inaqueous medium using an acidified mixture of potassium bromate andpotassium bromide as a source of bromine. The chlorination of thesecompounds was carried out using sulphuryl chloride as a chlorinatingagent in chloroform or diethyl ether. Anhydrous aluminium chloridewas used as a catalyst in the chlorination of the fluoroanilines. All the reaction products obtained were analyzed by fluorine-19 nuclear magnetic resonance spectroscopy (F n.m.r. spectroscopy),

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Carter, Jason W. "First principles in Aristotle's psychology : the science of soul in De Anima 1." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:5321c889-bce7-4e4f-a3f8-860b286c3380.

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This thesis analyses the method, purpose, and results of Aristotle's treatment of a select number of Presocratic and Platonic theses about the soul within the context of De Anima 1. Contrary to a prevalent interpretation of De Anima 1 which sees Aristotle's treatment of his predecessors' psychological views as dialectical, I argue that Aristotle treats his predecessors as having offered potentially viable hypotheses about the nature of the soul, and that these hypotheses are treated as attempts to explain the soul's basic powers. I further show that, in order to test the explanatory limits of

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Pearse, Jane Elizabeth. "Factors that impede the adoption of TQM in Professional Scientific Organisations." Thesis, University of Brighton, 1997. https://research.brighton.ac.uk/en/studentTheses/46f01eeb-8cc0-48c3-bc37-6dcbeb2eba18.

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This thesis reports on the implementation of TQM in the unusual environment of two Professional Scientific Organisations. An action research case study was concluded in the first organisation which had implemented an unconventional form of TQM. A corroborating case study was conducted in the other which had implemented "traditional" TQM.

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Green, Laura. "Assessing the nature of early farming in Neolithic western Asia : a functional ecological approach to emerging arable weeds." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:09a905ab-e375-4d45-bc27-d12cc21e9451.

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Research on the origins of agriculture in western Asia has placed great emphasis on the location and pace of domestication. However, much less attention has been given to reconstructing the specific nature and social implications of early cultivation practices across the agricultural transition, and to the potentially varied land management strategies involved. By employing a functional ecological approach to the interpretation of arable 'weed' taxa associated with early cultivars, this research addresses this gap in archaeobotancial research by enabling detailed analysis of the growing condit

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Bessou, Margaux. "Contribution de la forme mitochondriale de Bcl-xL dans le contrôle de la migration cellulaire." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1104/document.

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Les protéines de la famille Bcl-2 sont les principaux régulateurs de la mort cellulaire par apoptose. Au sein de cette famille, la protéine Bcl-xL appartient au sous-groupe des anti-apoptotiques et contribue à maintenir la survie cellulaire. Cependant, des données récentes suggèrent que les membres de la famille Bcl-2, et en particulier Bcl-xL, ont également d'autres fonctions.Dans le contexte pathologique du cancer du sein, la surexpression du gène Bcl-x n'affecterait pas la taille de la tumeur initiale mais favoriserait plutôt l'invasion ganglionnaire et la formation de métastases. La capaci

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EL, Dhaybi Mohamad. "Déterminants moléculaires non-apoptotiques de l'activité oncogénique de Bcl-xL : rôle de la monodéamidation de Bcl-xL." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0034/document.

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Bcl-xL est un oncogène surexprimé dans plusieurs types de cancers et qui joue un rôle important dans la survie cellulaire en régulant deux processus: l'apoptose et l'autophagie. Récemment, nous avons identifié l'existence d'une nouvelle forme de Bcl-xL qui subit une simple déamidation sur le résidu Asn52. Cette forme monodéamidée est exprimée en conditions contrôles et apparaît spontanément in vitro et in vivo. La déamidation de Bcl-xL produit un mélange de protéines contenant en position 52 soit un résidu Asp, soit un résidu isoAsp. L'objectif de cette thèse est de caractériser les fonctions

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Kunze, Doreen [Verfasser], Pée Karl-Heinz [Akademischer Betreuer] van, and Manfred P. [Akademischer Betreuer] Wirth. "Small interfering RNA-vermittelte Hemmung der Apoptoseinhibitoren BCL2, BCL-XL, XIAP und Survivin in Zellkultur- und Mausmodellen des humanen Harnblasenkarzinoms / Doreen Kunze. Gutachter: Karl-Heinz van Pée ; Manfred P. Wirth. Betreuer: Karl-Heinz van Pée." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://d-nb.info/1067729836/34.

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Sonntag, Christina. "Charakterisierung der humoralen Immunantwort nach Phagenidiotypvakzinierung im murinen BCL1-Lymphommodell." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-80058.

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Heath-Engel, Hannah. "Novel roles for Bcl2 family proteins at the endoplasmic reticulum." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96894.

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The Bcl2 family proteins are central regulators of apoptosis; the primary form of physiological cell death. Furthermore, inappropriate activation or silencing of Bcl2 family members has been associated with cancer development and treatment resistance. These proteins therefore represent attractive therapeutic targets, and, in consequence, an increased understanding of the roles played by Bcl2 proteins will be important for the development and implementation of targeted therapies. Although best characterized with respect to their role at the mitochondria, it is now evident that Bcl2 proteins als

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Wakefield, Alison. "Role of Bcl3 in the normal and neoplastic mammary gland." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55135/.

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The NF-kB family of transcription factors have previously been shown to be elevated in many malignant diseases including breast cancer. NF-kB activation is strongly associated with signalling downstream of the epidermal growth factor (EGF) family of receptors in both aggressive EGFR-positive and ERBB2-positive breast cancer subtypes. These observations have led to much interest in the use of NF-kB inhibitors to suppress tumour progression in breast cancer patients. However, as NF-kB controls numerous functions in homeostasis there are significant risks associated with sustained global inhibiti

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Cartlidge, Rachael Charlotte. "The Epstein-Barr virus BCL-2 homologues : interactions with cellular BCL-2 proteins and their role in apoptosis." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5898/.

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Epstein-Barr virus (EBV) encodes two viral BCL-2 homologues, BHRF1 and BALF1. BHRF1 is expressed in a subset of EBV-positive Burkitt’s lymphoma (BL) tumours; as BHRF1 is highly anti-apoptotic, expression could result in treatment-resistant BL. Little is known about BALF1, including whether BALF1 is pro- or anti-apoptotic. Interactions between BHRF1 and cellular BCL-2 homologues have not been fully characterised, but previous studies have focused on BIM as a key binding partner. We stably expressed wild-type or mutant vBCL-2s in EBV-negative BL lines to investigate interactions between BHRF1 an

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Dupont, Salomé. "Développement d’un modèle préclinique de leucémogénèse expérimentale chez la souris humanisée." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEP057/document.

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Les modèles animaux actuellement disponibles pour l’étude des leucémies humaines ne sont pas adaptés pour le développement optimal de nouvelles thérapies ciblées. Au cours de ce projet, qui s’inscrit dans une double perspective fondamentale et industrielle, nous avons cherché à générer un modèle versatile de leucémogénèse humaine chez la souris humanisée BRGS (BALB/c Rag2-/- IL-2Rγc-/- SIRPα.NOD). Les animaux sont greffés avec des progéniteurs hématopoïétiques transduits par des vecteurs lentiviraux surexprimant les oncogènes MYC et BCL2 et placés sous le contrôle d’un promoteur ubiquitaire (E

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Charlé, Christoph. "Kontrolle der Expression des Apoptoseregulatorgens bcl-x." [S.l.] : [s.n.], 1999. http://www.diss.fu-berlin.de/2000/106/index.html.

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Abou, samra Alma. "Conception, synthèse et évaluation biologique d’inhibiteurs des protéines anti-apoptotiques de la famille Bcl-2." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS390/document.

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La mitochondrie joue un rôle capital dans la mort cellulaire programmée ou apoptose par l’intermédiaire des protéines de la famille Bcl-2. Le dérèglement de l'apoptose dans de nombreux cancers fait de cette voie et des protéines de la famille Bcl-2 des cibles prometteuses pour la thérapie anti-cancéreuse. Le développement de petites molécules ciblant les protéines de la famille Bcl-2 s’est toutefois révélé être un grand défi, et peu d’entre elles ont atteint des études de phase clinique. Cependant, depuis une quinzaine d’années, grâce à des approches variées et souvent innovantes, des composés

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