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Rozprawy doktorskie na temat „Bioactive”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Wilcox, Matthew David. "Bioactive alginates." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578262.

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Alginates are polysaccharides extracted from the cell walls of brown seaweed or from certain bacteria such as Azotobacter vinelandii. Alginates have been shown to reduce the activity of pepsin and initial data suggest that it may affect the activity of pancreatic lipase. Pancreatic lipase plays an important role in the breakdown of triacylglycerol, if the activity of pancreatic lipase can be reduced then the breakdown of triacylglycerol would be reduce which in turn would lower the amount absorbed by the body. A pharmaceutical treatment for obesity called orlistat inhibits lipase and accounts

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2

Woods, Katherine B. "Bioactive natural products." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/26234.

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Montbretins A-E were isolated from the corms of Crocosmia sp., an invasive perennial plant. The montbretins are inhibitors of human pancreatic α-amylase (HPA). Montbretin A (2- 30) is a competitive inhibitor of HPA with a K₁ of 1.3 nM. The activity of the other family members varied significantly and provided structure-activity information. Saturation Transfer Difference (STD) NMR spectroscopy was used to determine that the caffeic acid region of the montbretins is important for binding. HPA is involved in the breakdown of complex carbohydrates; inhibition of this enzyme could help with regula

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3

Drummond, Allison K. "Bioactive metabolites from microorganisms /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/drummonda/allisondrummond.pdf.

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Lavelle, S. P. "Characterisation of bioactive aerosols." Thesis, London South Bank University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618633.

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5

Desjardine, Kelsey Lorne. "Bioactive marine natural products." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31286.

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The chemical exploration of extracts from cultures of the marine bacterial isolate PNG-276 yielded the novel antibiotic tauramamide (2.13), a non-ribosomal peptide active against cultures of Enterococcus sp. and methicillin-resistant Staphylococcus aureus (MRSA). A study of extracts of the marine sponge Spirastrella coccinea yielded the novel macrolide methylspirastrellolide C (3.14), which is active against protein phosphatase 2A (PP2A). A third study examined sponge extracts active in a cannabinoid receptor assay, yielding two known compounds, an A- nor -steroid derivative (4.10) and bengami

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6

Zhang, Yulan. "Diffusion of bioactive molecules." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/3982/.

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An artificial liposome membrane system has been employed for in vitro screening of the human absorption of biologically active molecules for applications in nutrition and drug treatments. Initial work with molecules having small permeabilities demonstrated that they could not be measured using the technique since they were absorbed by the membrane. A critical innovation was to pre-treat the membrane by equilibrating it with the molecule of interest since this avoids the absorption problem but required more complex data analysis. Bioactive molecules with strong antioxidant and anti-cancer activ

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Xinping, X. "Bioactive peptides from phyllomedusinae." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677853.

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For thousands of years, Nature has' been considered to be essential for human beings for the treatment of their diseases. Amphibians are an important component of the Animal Kingdom and have played a significant role in sourcing many active compounds and some therapeutics. In the course of this research, genomic and proteomic techniques have been used to investigate the bioactive peptides from the skin secretions of four American amphibian species: the Central American red-eyed leaf frog, Agalychnis callidryas~ the South American orange-legged leaf frog, Phyllomedusa hypochondrialis, Rohde's l

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8

She, Fengyu. "Development of Bioactive Peptidomimetics." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7571.

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Peptidomimetics are synthetic foldamers that expected more resistant to proteolytic degradation and enormous chemodiversity when compared with peptides. To date, the functional peptidomimetics such as β-peptides, peptoids, oligoureas, etc have been developed in many science fields. In order to explore the unnatural foldameric architectures, it’s necessary to discover the novel frameworks and molecular scaffolds. γ-AApeptides were reported to be a new class of peptidomimetics that showed its potential applications in drug discovery and chemical biology. However, a wide function and property of

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9

Martínez, Subirà Mariona. "Hull-less and coloured-grain barley as a source of valuable healthy bioactive compounds." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672377.

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Tot i que poques vegades es fa servir en els aliments, l'ordi està rebent un interès creixent com un gra saludable, per les seves propietats nutricionals. Es van estudiar a camp genotips d'ordi sense cobertes i de gra acolorit que es diferenciaven en una varietat de compostos bioactius valuosos i saludables, en diferents condicions ambientals i de temperatura. L'estrès per alta temperatura durant l'ompliment del gra va augmentar la concentració de compostos bioactius claus en el gra. S'ha de considerar la collita primerenca de grans immadurs per maximitzar la capacitat antioxidant. El 30% més

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10

Sandoval, Sandoval Viviana Paz. "Impact on gene expression and metabolic homeostasis of bioactive compounds-enriched diets." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671150.

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The excess of fat deposits are originated by a prolonged imbalance between the energy intake and the energy expenditure. The current food pattern based on a high consumption of saturated fats, simple sugars and processed foods, together with the sedentary lifestyle of the population, favor the development of obesity, which is responsible for 3.4 million deaths per year and is the main risk factor for the development of associated comorbidities, such as type 2 diabetes mellitus, non-alcoholic fatty liver and cardiovascular diseases. Given the current pandemic scope of obesity,

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11

Barros, Manuel João Salazar Guedes de. "Fabrication of hydrogel-bioactive glass composite scaffolds for bone tissue engineering." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17461.

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Mestrado em Materiais e Dispositivos Biomédicos<br>Bone is an extremely important connective tissue in the human body, as it provides support and protection of internal organs, being also metabolically relevant as the main mineral reservoir and assuring haematopoiesis through the bone marrow. Due to the current ageing of the population, an increase in bone tissue related diseases is noticeable. Thus, more efficient therapies for treating bone diseases is crucial. Tissue Engineering appears as a promising technology for treating several of those problems, such as bone loss and joint problems.

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12

Bissegger, Sonja. "Production of bioactive soy peptides /." Sion, 2008. http://doc.rero.ch/record/10790?ln=fr.

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13

Zheng, Zehua. "Synthesis of bioactive natural products." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59815.

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Crude extracts of the rare macrofungus Serpula sp. collected from a wooded area in Sri Lanka showed antimicrobial activity. The novel fungal metabolite serpulanine (2.1) was isolated from the crude extract in very small amounts along with a number of additional secondary metabolites. In order to obtain sufficient quantities of serpulanine (2.1) for biological evaluation, a synthetic route was developed to the natural product and a small library of analogs that have been evaluated in a panel of bioassays. Serpulanine (2.1) inhibits the histone deacetylase I/II with a clear dose response curve.

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14

MacKinnon, Shawna. "Bioactive triterpenoids of the Rutales." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9678.

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This thesis describes the investigation of the bioactivity of triterpenoids, limonoids and spiro-triterpenoids, isolated from the order of the Rutales. The focus of this research has been towards the development of botanical insecticides with non-neurotoxic modes of action in insects. It follows the recent development of Neem (Azadirachta indica, Meliaceae) as a botanical insecticide containing a limonoid azadirachtin as its main active compound. Because so few Meliaceae members have been examined for insecticidal activity the project was initiated by the screening of over sixty ethanol extrac

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15

Brastianos, Harry Charilaos. "Bioactive natural products from nature." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/3960.

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Bioassay guided fractionation of a crude extract of the marine sponge Neopetrosia exigua resulted in the first reported isolation of exiguamines A and B. These pyrroloquinone alkaloids have an unprecedented hexacyclic skeleton that has not been previously encountered in natural products. Biological studies have identified exiguamine A as a potent in vitro inhibitor of the enzyme indoleamine-2,3-dioxygenase (IDO). IDO is an enzyme expressed by tumor cells to evade the immune system. Inhibitors against this enzyme may allow the immune system to attack cancer cells, making this enzyme a potential

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16

Nelson, A. "Synthesis of bioactive indolizidine alkaloids." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421009.

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17

Ripley, Mark Brian. "Hydrocarbon bioremediation using bioactive foam." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313765.

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18

Chater, Peter. "Bioactive alginates and macronutrient digestion." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2460.

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Macronutrient digestion is a major factor in health and metabolic diseases such as obesity and diabetes and presents a huge global challenge. Modulating macronutrient digestion with food additives and pharmaceuticals has been shown to be a fruitful approach to the treatment of obesity (Orlistat) and diabetes (Acarbose). Previous work has shown that bioactive agents have novel modulatory effects on the major enzymes of digestion, and work in this lab has shown that specific alginates can inhibit pancreatic lipase up to 70%. Alginates are now being investigated as a potential anti-obesity agent.

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19

Forto, Chungong Louis. "Structural characterisation of bioactive glasses." Thesis, Aston University, 2018. http://publications.aston.ac.uk/37835/.

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Bioactive glasses are of great importance for orthopaedic and dental applications. The macroscopic properties of bioactive glasses, and in particular the rate of dissolution, can be tailored for specific applications by altering the compositions. It is therefore important to understand a compositional-structural-relationship as this will help when predicting glass properties and for optimising the design of future glasses for clinical applications. This thesis focused on the structural-characterisation of a wide range of bioactive glasses that are important for orthopaedic and dental applicati

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20

Place, Elsie Sarah. "Bioactive hydrogels for tissue engineering." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/7106.

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Modern tissue engineering (TE) scaffolds are expected to actively promote tissue repair as well as meeting the traditional requirements of non-toxicity, degradability and structural integrity. This thesis presents two novel bioactive hydrogel systems for bone and cartilage TE. A series of alginate hydrogels were developed in which all or a fraction of the calcium normally used for crosslinking alginate was replaced by bioactive strontium and/or zinc ions. Strontium was chosen for its ability to stimulate bone formation, while zinc is essential for alkaline phosphatase activity. Due to an inter

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21

Fitzgerald, Victoria. "Structural characterisation of bioactive glasses." Thesis, University of Kent, 2007. https://kar.kent.ac.uk/38707/.

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Melt-quenched glasses containing SiO2, CaO, Na2O and P2O5, and sol-gel derived glasses containing SiO2 and CaO are known to have bioactive properties. Foaming of binary sol-gel derived bioactive glasses containing SiO2 and CaO can be used to produce 3D porous scaffolds which mimic the structure of trabecular bone, increasing the potential for these glasses to be used as bioactive bone-regenerative materials. A range of experimental techniques have been used to investigate the atomic scale structure of these materials, and also to observe the reaction mechanisms which occur when these materials

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22

Salunke, G. B. "Enantioselective synthesis of bioactive molecules." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2009. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2727.

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23

Sunyer, Figueres Mercè. "Protective effects of bioactive compounds against fermentation-associated stresses in Saccharomyces cerevisiae." Doctoral thesis, Universitat Rovira i Virgili, 2021. http://hdl.handle.net/10803/672968.

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La melatonina i l’hidroxitirosol són molècules bioactives importants en diversos processos biològics en mamífers, principalment pel seu rol antioxidant. Són sintetitzades pels llevats durant la fermentació alcohòlica i la melatonina té efectes protectors contra l’estrès oxidatiu i la radiació UV en llevats. L’objectiu d’aquesta tesi ha estat determinar si la melatonina i l’hidroxitirosol protegeixen les cèl·lules de Saccharomyces cerevisiae contra estressos relacionats amb la fermentació. Per aprofundir en els mecanismes antioxidants de la melatonina, hem analitzat el seu efecte a nivell

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24

Pishbin, Fatemehsadat. "Development and characterisation of bioactive coatings based on biopolymer and bioactive glass obtained by electrochemical means." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11591.

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In spite of their widespread application, metallic orthopaedic prosthesis failure still occur due to lack of sufficient bone-bonding and the incidence of post-surgery microbial infections. The goal of this research was to develop multifunctional composite polymer/bioactive glass coatings as a potential strategy to improve surface properties of metallic implants. Using this approach, the bioactive glass improves osseointegration and the polymer plays a dual role: firstly to improve mechanical properties and secondly as a carrier for the release of therapeutics at the implantation site. Electrop

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25

Sharp, Koty. "Marine invertebrate-microbial bioactive metabolite symbioses." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3190794.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed Mar. 15, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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26

Tasso, Mariana Patricia. "Bioactive coatings to control marine biofouling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-25187.

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The colonization of immersed surfaces by a myriad of marine organisms is a complex, multi-stage, species-specific process giving rise to economic and environmental costs. This unwanted accumulation of organisms in the marine environment, called biofouling, has been attacked from different fronts, going from the ‘problem-elimination-as-problem-solving’ strategy (essentially through the use of biocides) to more elaborated and environmentally-friendly options based on the principle of ‘non-stick’ or ‘easy foul-release’ surfaces, which do not jeopardize marine life viability. Several marine organi

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27

Walsh, Anthony. "Novel methods to access bioactive molecules." Thesis, University of Huddersfield, 2015. http://eprints.hud.ac.uk/id/eprint/26947/.

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This thesis is divided into two chapters detailing research on applying microwave methodology to access aminated nucleosides in significantly reduced time frames, and applying the Belluš-Claisen reaction to produce non-proteogenic dipeptides. 1. Amination of Nucleosides Using Microwave Methodology 2,2’-Anhydrouridine undergoes a ring opening reaction with aliphatic amines to give the corresponding aminated product. Under conventional heating reaction times are extremely lengthy, taking at least 3 to 4 days and up to a month in the case of very hindered amines. A modified procedure using microw

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28

Agocs, Lisa Lynn. "Design of bioactive chalcogenobismuth(III) heterocycles." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24728.pdf.

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29

Li, Guoqiang. "Structure elucidation of bioactive natural products." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ29469.pdf.

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30

Setyawati, Ika Agustin. "Coordination chemistry : basics to bioactive molecules." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/NQ46420.pdf.

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31

Refai, Essam. "Bioactive peptides and proteins in disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-914-5/.

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32

Saralidze, Ketie. "Radiopaque bioactive microspheres as injectable biomaterials." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=9709.

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33

Ton, That Peter Tuan. "Fatigue characterisation of bioactive HAPEX'T'M composite." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341932.

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34

Bleach, Nicola Clare. "Optimisation of degradable bioactive polymer composites." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271820.

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35

Thompson, Ian Dennis. "Development of a mouldable bioactive composite." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326263.

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36

Bellatone, Maria. "Sol-gel derived antimicrobial bioactive glass." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394943.

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Shan, Yulong. "Bioactive carbohydrates : isolation, synthesis and conjugation." Thesis, Bangor University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556079.

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In this thesis four projects related to bioactive carbohydrates are described. The first project is about the extraction of iminosugars from Hyacinthoides non-scripta. This is the first time that extraction from English bluebell seeds has been described. Efficient extraction and isolation methods are reported. Another project discusses the development of a total synthetic carbohydrate conjugate vaccine candidate against Streptococcus pneumoniae type 14 using Gold nanoparticles as carrier. The synthetic pathway of the introduction of a linker for conjugation, and the deprotection of the tetrasa

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38

Husain, Rhonda. "Conformational studies on potentially bioactive peptides." Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333817.

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Carbain, Benoît. "A convenient synthesis of bioactive cyclohexenephosphonates." Thesis, University of Sussex, 2010. http://sro.sussex.ac.uk/id/eprint/2367/.

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Influenza virus infection and the shikimic acid pathway are two of many examples of microbe-host interactions and microbial biosynthetic pathways that are interesting for investigation by means of small molecules. A particularly interesting structural motif common to both is the cyclohexenecarboxylic acid. In the former, this structural motif has been employed as a mimetic of the sialyl cation intermediate and forms the scaffold of the anti-influenza drug and neuraminidase inhibitor Oseltamivir (or TamifluTM). In the latter pathway, crucial modifications towards aromatic amino acids are carrie

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40

Pinto, Vieira Vânia Margarida. "Orthogonal self-assembly of bioactive hydrogels." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19305/.

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Hydrogels are of great interest due to their ability to encapsulate and deliver bioactive molecules, mimic the extracellular matrix (ECM) and act as an artificial 3D scaffold. Here we report multi-component hydrogels based on low-molecular-weight gelators (LMWGs) and polymer gelators (PGs) incorporating heparin that can bind to self-assembled molecules, and their potential for controlled release and to mimic the ECM. These multi- component systems were characterised and the orthogonality of each individual component investigated. Firstly, three cationic surfactants were synthesised and their a

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41

Krause, Andrew Leslie. "Network modelling of bioactive porous media." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:980a0fd8-96a7-4818-904a-0842d4efbd41.

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In this thesis we consider several approaches to modelling interactions between fluid flow and cell proliferation in a bioactive porous medium. This is motivated by models of cell growth within tissue engineering scaffolds placed in perfusion bioreactors. These scaffolds are porous materials used to facilitate nutrient transport to cells placed within them. Recent modelling efforts have sought to understand the influence that cells have on the effective permeability of these tissue scaffolds, and hence on the capacity of the porous medium to facilitate fluid and nutrient transport, which enhan

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42

Usai, Igor. "Synthesis of novel bioactive doxycycline derivatives." kostenfrei, 2008. http://www.opus.ub.uni-erlangen.de/opus/volltexte/2008/1082/.

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Kamitakahara, Masanobu. "Preparation of bioactive inorganic-organic hybrids." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148834.

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Greasley, Sarah Louise. "Bioactive glass nanoparticles for therapeutic applications." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58227.

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There is great therapeutic potential for bioactive glass nanoparticles, as they can be internalised within cells and achieve sustained intracellular delivery of active ions. Bioactive glass nanoparticles are also used in nano-composites. The Stӧber process is commonly used for synthesising spherical silica particles. This thesis reports a comprehensive study of how the process variables can be systematically altered to obtain monodispersed particles of specific sizes in the range 20 – 500 nm. Modification of the Stӧber process so that the particles can contain cations such as calcium, which ca

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45

Hagos, Selam. "Chemical Investigation of Bioactive Marine Extracts." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7301.

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Natural products have been a fundamental source of medicinal scaffolds for decades; with sixty percent of marketed drugs. Many synthetic chemists are focused on synthesizing potent and nontoxic compounds for pharmaceutical targets, however, nature is still proving to be a source of new bioactive compounds. Produced by the host organism for defense, reproduction and communication, secondary metabolites also demonstrate promising bioactivity against human pathogens. Hence, natural product chemists continue their quest for new leads. As a continuation

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46

Hu, Yaogang. "Design and Synthesis of Bioactive Peptidomimetics." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5504.

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Protein-Protein Interactions (PPIs) play a very important role in biological functions and therefore the inhibition of specific Protein-Protein Interactions has a huge therapeutic value. The most successful small molecular PPIs inhibitors do not fit with the prevalent `Rule of Five' drug profile. To overcome the disadvantages of small molecular PPIs inhibitors, peptide based PPIs inhibitors were developed. Herein we describe the development of a new class of peptidomimetics AA-peptides. The AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides tha

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47

Lahore, S. "¿SYNTHETIC STUDIES TOWARDS BIOACTIVE FUNGAL METABOLITES¿." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229905.

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The problem of the development of new pesticides is very urgent, mainly because of the appearance of pest forms resistant to permitted pesticides and for the strict requirements in terms of their safety for people and the environment. Small molecules produced in biological contexts have been, and still are, a large reservoir of new biologically active substances, which can become scaffolds for the discovery of new agrochemicals. The aim of this PhD work was to synthesize naturally occurring potentially antifungal and herbicidal compounds and to test their biological activity. Efforts mainl

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48

Mendiola, Lanao Mónica. "Caracterización de compuestos bioactivos y efecto de la aplicación de Pulsos Eléctricos de Moderada Intensidad de Campo en setas cultivadas en La Rioja." Doctoral thesis, Universitat de Lleida, 2017. http://hdl.handle.net/10803/456031.

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L'objectiu principal de la present tesi doctoral va ser la caracterització de bolets cultivats a la Rioja, especialment pel que fa al seu contingut de compostos bioactius, i explorar l'efecte que podria tenir l'aplicació de Polsos Elèctrics de Moderada Intensitat de Camp (PEMIC) sobre aquests continguts aplicats tant en els substrats de cultiu com en els cossos fructífers. Per això, es va realitzar una caracterització inicial dels bolets cultivats a les instal·lacions del Centro Tecnolígico del Champiñón (CTICH) mitjançant anàlisi de composició centesimal i energia, així com del contingut en f

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Chyan, Ming-Kuan. "Synthesis and Study of Bioactive Compounds: I. Pyrethroids; II. Glutathione Derivatives." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278848/.

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Part I: In the first study of pyrethroids, twenty-one novel pyrethroid esters bearing strong electron-withdrawing groups (e.g., halomethylketo and nitro groups) in the double bond side chain of the cyclopropane acid moiety have been synthesized and evaluated for insect toxicity. Rather than the usually employed Wittig reaction for these syntheses, the novel pyrethroid acid moieties were prepared by amino acidcatalyzed Knoevenagel condensations under mild conditions. In the second study of pyrethroids, fourteen pyrethroid-like carbonates were synthesized by condensation of a variety of alcohol

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Semak, Vladislav. "Synthesis of 1S-ethyl-4-substituted quinolizidines and other potentially bioactive compounds." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97241.

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Esta Tesis Doctoral se presenta como Compendio de publicaciones. Los capítulos en los que se ha dividido la presente Tesis son los siguientes: Capítulo 1 – parte A: Enantioselective, Protecting Group-Free Synthesis of 1S-Ethyl-4-Substituted Quinolizidines Se ha descrito una síntesis enantioselectiva que no implica grupos protectores para acceder a la quinolizidina clave 6 a partir de la lactama bicíclica derivada de fenilglicinol 1. La adición de un reactivo organometálico a 6 ocurre de manera estereoselectiva para conducir a las quinolizidinas 1S-etil-4-sustituidas 4-epi-207I y 7-9. Sigu

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