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Gotowe bibliografie tematyczne / Bioanalytical study

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Gotowa bibliografia na temat „Bioanalytical study”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Bioanalytical study"

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Makowski, Nina, Agnes M. Ciplea, Mohsin Ali, Ilja Burdman, Anke Bartel, and Bjoern B. Burckhardt. "A comprehensive quality control system suitable for academic research: application in a pediatric study." Bioanalysis 12, no. 5 (2020): 319–33. http://dx.doi.org/10.4155/bio-2019-0242.

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Aim: Clinical research in pediatrics is progressively initiated by academia. As the reliability of pharmacodynamic measures is closely linked to the quality of bioanalytical data, bioanalytical quality assurance is crucial. However, clear guidance on comprehensive bioanalytical quality monitoring in the academic environment is lacking. Methods & results: By applying regulatory guidelines, international recommendations and scientific discussions, a five-step quality control system for monitoring the bioanalysis of aldosterone by immunoassay was developed. It comprised performance qualificat

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Singh, Anamika, and Tamanna Narsinghan. "BIOANALYTICAL METHOD VALIDATION: A COMPREHENSIVE ASSESSMENT OF VARIOUS REGULATORY GUIDELINES." Indian Drugs 60, no. 06 (2023): 7–25. http://dx.doi.org/10.53879/id.60.06.12583.

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Bioanalytical methods are used to analyse an analyte in a biological matrix. Bioanalytical method validation is the process of determining the suitability of the given bioanalytical methodology for providing the required analytical data. Validation of the bioanalytical methods demonstrates and ensures that the methods used for the quantification of analyte in biological fluids are reliable, reproducible and suitable for its intended application. Different regulatory agencies like Food and Drug administration (FDA), The National Health Surveillance Agency or Agência Nacional de Vigilância Sanit

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Sun, Yuchen, Shin-ichiro Nitta, Kosuke Saito, et al. "Development and multicenter validation of an LC–MS-based bioanalytical method for antisense therapeutics." Bioanalysis 14, no. 18 (2022): 1213–27. http://dx.doi.org/10.4155/bio-2022-0126.

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Background: Many bioanalytical methods for antisense oligonucleotides (ASOs) using LC–MS have been reported. However, no data have been available on the reproducibility and robustness of a single bioanalytical method for ASOs. As such, in the current study, we evaluated the reproducibility and robustness of LC–MS-based bioanalytical methods for ASOs in multiple laboratories. Methods/Results: Seven independent laboratories were included in this study. Mipomersen was measured by ion-pairing LC–MS (IP-LC–MS) as a model ASO using different LC–MS. The validation results of calibration curve, accura

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Mrinalini, C. Damle* and Sanchita A. Kale. "DETERMINATION OF ETRAVIRINE IN HUMAN PLASMA BY HPLC." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1657–64. https://doi.org/10.5281/zenodo.821178.

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A simple bioanalytical HPLC method for the estimation of Etravirine in human plasma has been developed and validated. Fenofibrate was used as an Internal Standard . Extracted sample was eluted using C18 (250 x 4.6 mm, 5 μm) column. The mobile phase consisted of Acetonitrile:Water in the ratio of 85:15 v/v which was sonicated to degas and delivered at a flow rate of 1 ml/min at ambient temperature. The retention time of Etravirine and Fenofibrate was 5.32(± 0.1) and 3.58(± 0.1) minutes respectively. Studies were performed using an HPLC system equipped with a UV detector; the response was monito

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Casero, E., A. Martinez G. de Quesada, J. Jin, et al. "Comprehensive Study of Bioanalytical Platforms: Xanthine Oxidase." Analytical Chemistry 78, no. 2 (2006): 530–37. http://dx.doi.org/10.1021/ac051676l.

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Flores-Cruz, Ricardo, Rafael López-Arteaga, Lizbeth Ramírez-Vidal, Fernando López-Casillas, and Arturo Jiménez-Sánchez. "Unravelling the modus-operandi of chromenylium-cyanine fluorescent probes: a case study." Physical Chemistry Chemical Physics 21, no. 28 (2019): 15779–86. http://dx.doi.org/10.1039/c9cp03256h.

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Neha, Gaikwad* Kanchan Shinde Varsha Pangale Charushila Bhangale. "Bioanalytical Method Development And Validation For The Estimation Of Active Pharmaceuticals In Dosage Forms." Int. J. in Pharm. Sci. 1, no. 2 (2023): 143–52. https://doi.org/10.5281/zenodo.7755584.

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In this review article, bioanalytical techniques are often employed to quantify pharmaceuticals and their metabolites in plasma matrices, and the techniques should be used in both human clinical investigations and nonhuman research. A key component of estimate and interpretation of bioequivalence, pharmacokinetic, and toxicokinetic investigations is the use of the bioanalytical technique for the quantitative measurement of medicines and their metabolites in biological medium. Method creation, method validation, and sample analysis are the three main responsibilities of bioanalysis. To determin

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Kellie, John F., Yun W. Alelyunas, Josh Albert, et al. "Intact mAb LC–MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples." Bioanalysis 12, no. 19 (2020): 1389–403. http://dx.doi.org/10.4155/bio-2020-0168.

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Background: Antibody biotherapeutic measurement from pharmacokinetic studies has not been traditionally based on intact molecular mass as is the case for small molecules. However, recent advancements in protein capture and mass spectrometer technology have enabled intact mass detection and quantitation for dosed biotherapeutics. A bioanalytical method validation is part of the regulatory requirement for sample analysis to determine drug concentration from in-life study samples. Results/methodology: Here, an intact protein LC–MS assay is subjected to mock bioanalytical method validation, and un

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Ge, Shencheng, Secil Koseoglu, and Christy L. Haynes. "Bioanalytical tools for single-cell study of exocytosis." Analytical and Bioanalytical Chemistry 397, no. 8 (2010): 3281–304. http://dx.doi.org/10.1007/s00216-010-3843-0.

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Bouchafra, Houda, Aimen El Orche, Choukri El Khabbaz, et al. "Determination and validation of tiaprofenic acid in human plasma: A detailed LC-MS/MS-based analysis following ICH M10 guidelines and the accuracy profile approach." Current Chemistry Letters 13, no. 4 (2024): 707–16. http://dx.doi.org/10.5267/j.ccl.2024.4.003.

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The validation of bioanalytical methods holds critical importance for regulatory agencies and organizations dedicated to ensuring the safety, efficacy, and quality of pharmaceuticals. In this context, the recent release of the ICH M10 guideline in May 2022 represents a significant milestone in standardizing bioanalytical method validation globally. However, this guideline lacks explicit experimental protocols for implementation. In this study, we address the practical implementation of the newly released ICH M10 guideline by providing a detailed validation protocol for a bioanalytical method.

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Rozprawy doktorskie na temat "Bioanalytical study"

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Venumuddala, Hareesha Reddy. "Study of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques." Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1295472144.

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Benabou, Zdaou Sanae. "Application of analytical and chemometric methodologies to study complex bioanalytical processes involving DNA i-motif structures." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663796.

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The i-motif is a DNA structure formed by cytosine-rich sequences that consists of parallel- stranded duplexes held together by intercalated base pairs. The in vitro formation of this structure in DNA sequences corresponding to the promoter regions of several oncogenes, such as c-kit, c-myc or bcl-2, has been demonstrated. Recently, the first direct evidence for its in vivo presence in human cells and control regulatory functions has been proven. This structure is not only interesting from a biophysical and biomedical point of view, but also for their potential application in Analytical Chemist

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Nukala, Sarath Babu. "Bioanalytical and proteomic approaches in the study of pathologic ECs dysfunctionality, oxidative stress and the effect of PFKFB3 modulators." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/671200.

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The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress increases the formation of reactive species (ROS), such as peroxides and hydroxyl radicals. ROS are signalling molecules and are able to induce leukocyte adhesion and promote the vascular endothelial permeability, that leads to the dysfunction of endothelium- related signal transduction pathways as well as redox-regulated transcription factors2. ROS cause reorganization of the actin filament, for

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NUKALA, SARATH BABU. "BIOANALYTICAL AND PROTEOMIC APPROACHES IN THE STUDY OF PATHOLOGIC ECS DYSFUNCTIONALITY, OXIDATIVE STRESS AND THE EFFECTS OF PFKFB3 MODULATORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/644236.

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Vascular dysfunction is one of the primary factors in the onset and progression of atherosclerosis and other vascular-related diseases such as acute myocardial infarction (AMI) and chronic thromboembolic pulmonary hypertension (CTEPH). Emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic alterations in endothelial cells (ECs). The identification of the insights and causes resulting in dysfunctional ECs is crucial for the understanding of the disease and to the development of new therapeutic tools. Therefore, to study the

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Medeiros, Francinalva Dantas de. "Investigação da influência da velocidade de liberação do fármaco metoprolol a partir da forma farmacêutica sobre seu processo de absorção e de seus enantiômeros." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-04042014-113927/.

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A Agência Nacional de Vigilância Sanitária (ANVISA) não exige a realização de ensaios de bioequivalência utilizando métodos enantiosseletivos de quantificação de fármacos para o registro de medicamentos genéricos ou similares contendo fármacos racêmicos. Porém, existe a possibilidade das diferenças de concentrações plasmáticas dos enantiômeros entre o medicamento referência e os genéricos e/ou similares comercializados no Brasil serem maiores que as estabelecidas pelos limites de bioequivalência. Esse estudo teve a finalidade de investigar a influência da velocidade de liberação do fármaco met

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Rolando, Justin Charles. "Bioanalytical Tools to Develop Rapid Diagnostics and Study Physiology." Thesis, 2019. https://thesis.library.caltech.edu/11559/13/Rolando_Final_v2.pdf.

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<p>This work details the development of bioanalytical tools for use in rapid diagnostics (Chapters 2-4) and in the study of physiology (Chapters 5-6). This research harness the power of real-time, singlemolecule microfluidics to study loop-mediated isothermal amplification in urinary tract infections (Chapter 2), chlamydia (Chapter 3), and gonorrhea (Chapter 4). In Chapter 5, non-reactive beads are designed and optimized to study the impact of polymers on murine gastrointestinal mucosa. Chapter 6 details the implementation of a mass spectrometry method to quantify bile acids and investigate th

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Hung, Cheng-Han, and 洪晟瀚. "Targeted and Untargeted Mass Spectrometry Analysis in Bioanalytical, Environmental, and Fundamental Study." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/93249521849327375311.

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博士<br>國立中興大學<br>化學系所<br>103<br>Mass spectrometric-based analytical methods have widely applied in proteomics, metabolomics, pharmaceutical, bioanalytical, forensic, food, and environmental science because of its high sensitivity and selectivity. According to the way of use, mass spectrometric-based analytical method could classify into two categories, targeted mass spectrometry analysis and untargeted mass spectrometry analysis. The first part of this dissertation describes the targeted mass spectrometry analysis and its application in environmental and bioanalytical study. Generally, there ar

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SINGH, LOVELY. "ANALYTICAL AND BIOANALYTICAL METHOD DEVELOPMENT OF MONOMETHYL FUMARATE AND ITS APPLICATION FOR PHARMACOKINETIC STUDY." Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18362.

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Monomethyl fumarate is the pharmacologically active metabolite of immune modulator dimethyl fumarate. It is used f0r the treatment 0f relapsing f0rms 0f multiple scler0sis, relapsing-remitting disease, and active sec0ndary pr0gressive disease, in adults. The maj0r 0bjective 0f this thesis was t0 devel0p selective and sensitive meth0d f0r HPLC and LCMS analysis 0f MMF, t0 study its pharmac0kinetics in rat plasma. The chr0mat0graphic separati0n was achieved 0n a HYPERSIL GOLD, 50 ×4.6 mm,5u C18 by using a 70:30 (v/v) mixture 0f acet0nitrile and 10mM amm0nium f0rmate as the m0bile p

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Ellis, Jonathan S. "The Study of Interfacial Dynamics at Biochemically Modified Surfaces Using Acoustic Wave Physics and Molecular Simulations." Thesis, 2009. http://hdl.handle.net/1807/17460.

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Detection of conformational and structural shifts in biomolecules is of great importance in bioanalytical chemistry and pharmaceutical sciences. Transverse shear mode acoustic wave devices have been used as real-time, label-free detectors of conformational shifts in biomolecules on surfaces. However, material changes in the biochemical monolayer and coupling between the substrate and the surrounding liquid make it difficult to isolate the desired signal, so an understanding of these phenomena is required. In this thesis, interfacial slip, viscoelasticity, and structural changes are used to mod

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Hu, Kang. "Two-capillary chemical cytometry : instrumental and methodological development of a new bioanalytical technology for asymmetric cell proliferation study /." 2004. http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss&rft%5Fval%5Ffmt=info:ofi/fmt:kev:mtx:dissertation&rft%5Fdat=xri:pqdiss:MQ99326.

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Thesis (M.Sc.)--York University, 2004. Graduate Programme in Biology.<br>Typescript. Includes bibliographical references (leaves 112-116). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss&rft%5Fval%5Ffmt=info:ofi/fmt:kev:mtx:dissertation&rft%5Fdat=xri:pqdiss:MQ99326

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Książki na temat "Bioanalytical study"

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Hou, Harvey J. M. Teaching Bioanalytical Chemistry. Oxford University Press, Incorporated, 2014.

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Części książek na temat "Bioanalytical study"

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Rykowska, Iwona, Iwona Nowak, and Wiesław Wasiak. "Selected Microextraction Techniques Using Ionic Liquids in the Study of Biologically Active Compounds." In Handbook of Bioanalytics. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95660-8_45.

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Rykowska, Iwona, Iwona Nowak, and Wiesław Wasiak. "Selected Microextraction Techniques Using Ionic Liquids in the Study of Biologically Active Compounds." In Handbook of Bioanalytics. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-63957-0_45-1.

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"Sponsor and FDA/Regulatory Agency GLP Inspections and Study Audits." In Regulated Bioanalytical Laboratories. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470920671.ch7.

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Jalal, Nahid Rezvani, Fariba Mollarasouli, Mohammad Reza Jalali Sarvestani, et al. "Quantum Dots in Medical Detection/Diagnosis." In Quantum Dots in Bioanalytical Chemistry and Medicine. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781839169564-00075.

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One area of interest in nanotechnology, particularly in nanobiotechnology, is the study of optical and electrical phenomena related to nanometer-scale semiconductors. Quantum dots (QDs) are semiconductor nanocrystals whose electrons and holes are quantum-confined in all three spatial dimensions. QDs’ unique optical features make them suitable for use as optical probes or as optically trackable biomolecule carriers for in vitro and in vivo research in biological applications. QDs can be used to target specific areas in vitro and in vivo by conjugating relevant functional biomolecules onto their

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"Polymer Characterisation." In Fundamentals of Inorganic and Organometallic Polymer Science. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781837672325-00100.

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It is one thing to assert that you have synthesised an inorganic or organometallic polymer, it is another thing to convince your peers that it is a polymer. Polymer characterisation provides data to prove your assertion. Polymer characterisation involves using analytical methods to ascertain the composition, structure, molecular weight, morphology, and bulk macroscopic properties of polymers. Information derived from characterisation studies confirms the polymeric nature of materials and reveals the inherent properties of materials. The studies also provide data to predict the performance of t

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"THE FACULTY OF PHARMACY AND THE COURSE OF STUDY." In English for Pharmacy and Medical Bioanalytics. Karolinum Press, Charles University, 2023. http://dx.doi.org/10.2307/jj.362399.4.

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Streszczenia konferencji na temat "Bioanalytical study"

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LaLone, V., M. Fawaz, M. Mourão, et al. "Bioanalytical Raman Spectral Cytometry of Alveolar Macrophages for the Quantitative Study of Idiopathic Pulmonary Fibrosis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6081.

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Yao, Shuhuai, Shulin Zeng, and Juan G. Santiago. "Temporal Response of Porous Glass Electroosmotic Pumps." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33679.

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Sintered glass electroosmotic pumps have been fabricated that provide maximum flow rates and pressure capacities exceeding 14 ml/min and 1.4 atm, respectively, at 150 V, with an active pumping volume of less than 2 cm3. These compact devices with no moving parts have the potential to impact a variety of applications including microelectronics cooling systems and bioanalytical applications. We present here a preliminary a study of the response of the pumps to changes in fluidic load, including their short-term transient performance. A 0.5 mM borate buffer (pH = 9.2) is used to stabilize pump pe

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RÜBENSAM, Gabriel, and Henrique Bordin Lucena BORGES. "VALIDATION OF A GC-FID METHODOLOGY FOR THE DETERMINATION OF 2,5-HEXANEDIONE IN URINE." In SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.33_abstract_borges.pdf.

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2,5-hexanedione is the main metabolite of hexane and methyl butyl ketone excreted into urine and is currently used to estimate the human exposure levels to these solvents in professional environments. In Brazil, occupational exposure is regulated by a national control program (PCMSO) and applied to public and private organizations that hire your employees according to the actual Brazilian legislation. In the present work, we validated a methodology based on a gas chromatography−flame ionization detector (GC-FID) for the quantification of 2,5-hexanedione in urine to attend the new occupational

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