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1

Nightingale, Joshua Ryan. "Optical biosensors SPARROW biosensor and photonic crystal-based fluorescence enhancement /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5818.

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Thesis (M.S.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains vi, 120 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 91-100).
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Ravindran, Ramasamy. "An electronic biosensing platform." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44774.

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The objective of this research was to develop the initial constituents of a highly scalable and label-free electronic biosensing platform. Current immunoassays are becoming increasingly incapable of taking advantage of the latest advances in disease biomarker identification, hindering their utility in the potential early-stage diagnosis and treatment of many diseases. This is due primarily to their inability to simultaneously detect large numbers of biomarkers. The platform presented here - termed the electronic microplate - embodies a number of qualities necessary for clinical and laboratory
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Kittichan, Kanokphandharangkul. "Aptamer biosensors." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/39048.

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Aptamers are single stranded nucleic acids, typically composed of between twenty to eighty nucleotides in length, capable of binding selectively to non-nucleic acid ligands. Aptamers are selected through a combinatorial chemistry process called Systematic Evolution of Ligands by Exponential enrichment (SELEX), which is composed of successive cycles of selection based on target affinity, followed by amplification. This results in the Darwinian evolution of the nucleic acid library resulting in increasing library homogeneity and target affinity over time. Aptamers have been extensively investiga
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Stevenson, Adrian Carl. "Electromagnetic biosensors." Thesis, University of Cambridge, 1995. https://www.repository.cam.ac.uk/handle/1810/252090.

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Ali, Momenpour. "Raman Biosensors." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36468.

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This PhD thesis focuses on improving the limit of detection (LOD) of Raman biosensors by using surface enhanced Raman scattering (SERS) and/or hollow core photonic crystal fibers (HC-PCF), in conjunction with statistical methods. Raman spectroscopy is a multivariate phenomenon that requires statistical analysis to identify the relationship between recorded spectra and the property of interest. The objective of this research is to improve the performance of Raman biosensors using SERS techniques and/or HC-PCF, by applying partial least squares (PLS) regression and principal component analysis (
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Williamson, Hodge Lucy A. "Microcantilever biosensors." Thesis, Heriot-Watt University, 2014. http://hdl.handle.net/10399/2739.

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The cross-sensitivity of microcantilever sensors presents a major obstacle in the development of a commercially viable microcantilever biosensor for point of care testing. This thesis concerns electrothermally actuated bi-material microcantilevers with piezoresistive read out, developed for use as a blood coagulometer. Thermal properties of the sensor environment including the heat capacity and thermal conductivity affect the ‘thermal profile’ onto which the higher frequency mechanical signal is superimposed. In addition, polymer microcantilevers are known to have cross-sensitivity to relative
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Cronin, Thomas. "Liquid crystal biosensors." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/liquid-crystal-biosensors(428e3ba0-bf7e-4dda-9eae-c44c9713c7bb).html.

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The aim of the thesis was to identify and hence investigate the physical properties of liquid crystals that influence their potential as components of biosensor devices. Silicon surfaces presenting photolithographically fabricated arrays of 50nm thick gold spots were used as the model for a biosensor that detects the surface binding of a biological analyte. The spots ranged in diameter from 2μm to 16μm and their spatial separation varied between 5μm to 40μm. A Self Assembled Monolayer (SAM) of the thiol 3-mercaoptopropionic acid was used to control the surface chemistry of the gold. The respon
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8

Bini, Alessandra. "Aptamers for biosensors." Thesis, Cranfield University, 2008. http://dspace.lib.cranfield.ac.uk/handle/1826/4004.

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Aptamers are single-stranded DNA or RNA molecules isolated in vitro by a selection and amplification method. Aptamers bind with high specificity and affinity to a wide range of target molecules, with dissociation constant comparable to antibodies. In this work aptamers were employed as a new kind of bio-recognition element in affinity biosensors for the detection of clinically relevant proteins in heterogeneous assay, using Piezoelectric Quartz Crystal Microbalance and Surface Plasmon Resonance as transducers. The work was focused on two case studies, i.e. the Thrombin-binding aptamer and the
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Mohd-Zawawi, Ruzniza. "Electrochemical chiral biosensors." Thesis, Durham University, 2011. http://etheses.dur.ac.uk/3200/.

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Recognition of chiral molecules in biological assemblies has been a subject of extensive research. The aim of this work was to fabricate and characterise biocompatible composite materials suitable for chiral recognition. Collagen, the most abundant chiral, extracellular protein, was chosen as a possible matrix. The chiral recognition properties were evaluated by a comparative study in collagen, collagen incorporated in tetramethyl orthosilicate (TMOS) and TMOS. In electrochemical studies, ferrocene was incorporated to facilitate electron transfer. The recognition characteristics of two chiral
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10

Tantra, Ratna. "Novel electrochemical biosensors." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300847.

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11

Robertson, Graeme. "Enzyme pesticide biosensors." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366815.

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12

Dalton, Colette. "Aptamers as biosensors." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=15484.

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Sivakumarasamy, Ragavendran. "0D nanotransistor biosensors." Thesis, Lille 1, 2015. http://www.theses.fr/2015LIL10034/document.

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L’objectif de cette thèse était d’explorer le potentiel des biocapteurs à base de transistors à 1 électron. Depuis l’invention de l’électrode de verre il y a plus de 100 ans, la réponse monotone du potentiel de surface avec le pH est devenue universelle. Aussi, il est bien connu que les mesures de la concentration en ions dans des solutions complexes, de grande importance pour le domaine biomédical, requière des membranes sélectives aux ions. En utilisant ces transistors nanométriques, nous montrons une rupture dans ces concepts avec l’observation d’une réponse en U au pH et la mesure sélectiv
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Rogerson, Jonathan G. "Biosensor technology : applications in microbial toxicology." Thesis, University of Bedfordshire, 1997. http://hdl.handle.net/10547/621817.

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This work describes the development of mediated amperometric biosensors that are able to monitor the metabolic activity of both single and mixed microbial populations, with applications in toxicity assessment and wastewater treatment plant protection. Biosensor systems have been constructed incorporating either the single-species eubacteria Escherichia coli or Pseudomonas putida, Bioseed®, or a mixture of activated sludge organisms from wastewater treatment plants, as the sensing components immobilised on disposable screen printed electrodes in stirred reaction vials. The biosensor approach is
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15

HOWARD, SHAUN CHRISTOPHER. "PHASE SEPARATION IN MIXED ORGANOSILANE MONOLAYERS: A MODEL SYSTEM FOR THE DEVELOPMENT OF NOVEL MEMBRANES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1123873986.

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16

Cullen, David Charles. "Conductimetric & optical biosensors." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293445.

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17

Shin, John J. H. "Lipids as pH biosensors." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45704.

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18

Whitehouse, Louise Elizabeth. "Inkjet printing for biosensors." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396947.

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19

Dennison, Manus. "Gas-phase enzyme biosensors." Thesis, Cranfield University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309584.

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20

Scullion, Mark Gerard. "Slotted photonic crystal biosensors." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/3405.

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Optical biosensors are increasingly being considered for lab-on-a-chip applications due to their benefits such as small size, biocompatibility, passive behaviour and lack of the need for fluorescent labels. The light guiding mechanisms used by many of them result in poor overlap of the optical field with the target molecules, reducing the maximum sensitivity achievable. This thesis presents a new platform for optical biosensors, namely slotted photonic crystals, which engender higher sensitivities due to their ability to confine, spatially and temporally, the peak of optical mode within the an
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21

Oltmanns, Jan. "Biosensors for heavy metals." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/22854.

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Heavy metals from natural and man-made sources can be a great threat to human and animal life. As small inorganic ions they are challenging to detect, usually requiring expensive and complicated machinery. Several heavy metals can accumulate in the human body, leading to long term toxic effects on the nervous system. Many bacteria have developed strategies to survive in heavy metal rich environments. One of these strategies is a bacterial operon containing genes for detoxification mechanisms controlled by a promoter and a regulatory protein. In this work some of these promoter-protein pairs, P
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22

Trouillon, Raphael. "Electrochemical biosensors and angiogenesis." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6120.

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Electrochemical methods provide attractive sensing techniques for biology. Electrochemical devices can be easily manufactured, miniaturized and are sometimes the only direct sensing method available. However, stability of these sensors is problematic, as foreign-body type reactions may induce distortions of the signal (biofouling). As a consequence, investigating the interactions with the biological matrix is of paramount importance to achieve reliable sensing. Different types of electrodes (boron doped diamond and different preparations of glassy carbon) and various electrode coatings were te
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23

Loebel, Nicolas G. "Singlemode fiber interferometric biosensors /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8026.

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24

Hanson, George T. "Green flourescent protein biosensors /." view abstract or download file of text, 2001. http://wwwlib.umi.com/cr/uoregon/fullcit?p3018368.

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Thesis (Ph. D.)--University of Oregon, 2001.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 151-157). Also available for download via the World Wide Web; free to University of Oregon users.
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25

Tsai, Long-Fang. "Microfluidic Devices and Biosensors." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5821.

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My research broadly covers various important aspects of microfluidic devices and biosensors. Specifically, this dissertation reports: (1) a new and effective room temperature method of bonding polydimethylsiloxane (PDMS) microfluidics to substrates such as silicon and glass, (2) a new microfluidic pump concept and implementation specifically designed to repeatedly drive a small sample volume (<1 µL) very rapidly (~500 µL/min) through a sensor-containing flow channel to significantly decrease sensor response time through advection-driven rather than diffusion-driven mass transport, (3) use of a
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26

Martins, Lucilene Dornelles Mello 1973. "Desenvolvimento de biossensores eletroquimicos como ferramenta para avaliação da capacidade antioxidante de extratos vegetais." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248401.

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Orientador: Lauro Tatsuo Kubota<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-04T04:12:52Z (GMT). No. of bitstreams: 1 Martins_LucileneDornellesMello_D.pdf: 8841041 bytes, checksum: f4618b120bf384d76c695743eb6ce4cc (MD5) Previous issue date: 2005<br>Doutorado<br>Quimica Analitica<br>Doutor em Quimica
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Kisner, Alexandre 1982. "Desenvolvimento de Microssensores do tipo ISFETs a base de Nanoeletrodos de Ag e Au." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248385.

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Orientador: Lauro Tatsuo Kubota<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-08T22:44:52Z (GMT). No. of bitstreams: 1 Kisner_Alexandre_M.pdf: 3973690 bytes, checksum: 2810b47ecfaaac028a1bf271a3fc25a0 (MD5) Previous issue date: 2007<br>Conjuntos de transistores de efeito de campo sensíveis a íons (ISFETs) foram desenvolvidos no presente trabalho. Implementou-se durante a fabricação destes uma etapa adicional de anodização que possibilitou a formação de uma fina camada de alumina porosa sobre suas portas. Esta serviu
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28

Peng, Haiqing. "The Performance of Silicon Based Sensor and its Application in Silver Toxicity Studies." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2613/.

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The silicon based sensor is able to detect part per trillion ionic silver in 0.0098% hydrofluoric acid based on the open circuit potential (OCP) measurement. The OCP jump of 100 ppt ionic silver solution is up to 120 mV. The complex agent can effectively suppress the ionic silver concentration and suppress the OCP signal. The ability of complex agent to suppress the OCP signal depends on the formation constant of the complex with silver. The complex adsorbed on the sensor surface induces a second OCP jump, the height of the second jump depends on the formation constant of the complex. The MIN
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Rong, Zhiyang. "Fabrication and characterization of carbon nanotubes for biomedical applications." Worcester, Mass. : Worcester Polytechnic Institute, 2008. http://www.wpi.edu/Pubs/ETD/Available/etd-082508-150545/.

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Panjan, P. (Peter). "Innovative microbioreactors and microfluidic integrated biosensors for biopharmaceutical process control." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526218199.

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Abstract Biopharmaceuticals are growing in medical and economical significance, replacing several chemically synthesized pharmaceuticals and providing new treatments for serious diseases. Research within the biopharmaceutical field is expensive and labor intensive with the majority of work featuring diverse bioprocesses. Miniaturization of bioprocesses into microbioreactors, miniaturized bioprocess vessels for diverse experiments, reduces the amount of necessary reagents as well as time and labor due to the possibility of multiplexing. A crucial step of research is analytics, commonly performe
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Mirasol, Sofia Paulo. "Optoelectronic properties of Quantum Dots for biomedicine and energy-to-light conversion." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668348.

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En les últimes dècades, la nanociència ha sorgit com una nova tecnologia gràcies a la seva versatilitat per ser emprada en diferents camps. Dins d’aquets grup, un dels nanomaterials més prometedors, els punts quàntics han estat estudiats per la seva extraordinària propietats i la seva versatilitat per utilitzar-los en diferents camps. La present tesis doctoral es centra en la síntesi de diferents punts quàntics, així com en el seu ús en LEDs, cèl·lules solars perovskites i biosensors. S'han sintetitzat tres tipus de punts quàntics: cadmi, perovskites i punts quàntics de carboni. Els dos p
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Kwan, Cheuk Hung. "Biosensors for biological nutrient monitoring /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202004%20KWAN.

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33

Coote, Joanna. "Semiconductor lasers as miniature biosensors." Thesis, University of Surrey, 2009. http://epubs.surrey.ac.uk/843373/.

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Biosensors are chemical sensors that use biological materials to detect the presence of the substance of interest. Optical methods to transduce the interaction between the analyte and the biological detection element are highly sensitive, non-invasive and are not subject to noise from electrical interference. Biosensors based on photonic devices such as lasers, optical fibres and photonic crystals offer the possibility of high sensitivity combined with small size, which is highly advantageous for in-the-field and remote applications. In this thesis, the feasibility of using semiconductor laser
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34

Ellis, April L. "Rational Design of Calcium Biosensors." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/chemistry_diss/25.

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Understanding the temporal and spatial changes in calcium concentration has been a difficult endeavor for many years due to the relatively small changes in calcium concentration during messenging events, the rapid changes upon physiological messenging, and the unavailability of fast, efficient, and sensitive sensors to detect calcium changes. In addition, the key factors in calcium binding have yet to be determined due to the metal-metal interactions, cooperativity, and conformational change involved in calcium binding to natural calcium-binding proteins. To overcome these obstacles and to eng
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35

Martens, Nicolas. "Aspects of mediated amperometric biosensors." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338022.

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36

Fragkou, Vasiliki. "Improvements in electrochemical glucose biosensors." Thesis, Cranfield University, 2010. http://dspace.lib.cranfield.ac.uk/handle/1826/6532.

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Diabetes is one of the leading causes of death and disability in the world. Even though insulin was discovered in 1920, an intense research on diabetes has been conducted during the last five decades and this is because of the market size. The huge demand is creating the need for the development of new approaches. This project involved the research aimed at better understanding and improvements in performance of glucose biosensors. In general, high surface area electrodes are desired as the high surface area provides more active sites for electrochemical reactions, and hence higher kinetic rat
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Ball, Mark. "Biosensors based on capacitance measurement." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363894.

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38

Murphy, Melanie Jane. "Automated biosensors utilising firefly bioluminescence." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391125.

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39

Durrant, S. L. T. "The development of novel biosensors." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47040.

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40

Robottom, Janice. "A split enzyme for biosensors." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20013/.

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Split enzymes have been used in Protein Complementation Assays (PCA) for several years to study protein-protein interactions. Recently Affimers, non-antibody binding proteins, have been created as new tools for studying molecular interactions. Combining these technologies offers substantial benefits for development of highly sensitive and specific diagnostic devices. For proof-of-principle, two fragments of β-lactamase have been generated with two His tags. The binding of the His tag on each fragment to nickel ions facilitates the association of β-lactamase fragments to generate a functional e
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41

Hammond, Jules L. "Micro- and nanogap based biosensors." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715307.

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Biosensors are used for the detection of a range of analytes for applications in healthcare, food production, environmental monitoring and biodefence. However, many biosensing platforms are large, expensive, require skilled operators or necessitate the analyte to be labelled. Direct electrochemical detection methods present a particularly attractive platform due to the simplified instrumentation when compared to other techniques such as fluorescence-based biosensors. With modern integrated circuit capabilities electrochemical biosensors offer greater suitability for monolithic integration with
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42

Bhalla, Nikhil. "Biosensors for drug discovery applications." Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683538.

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This research developed a biosensor for kinase drug discovery applications. In particular it combined electronic techniques with optical techniques to understand the phosphorylation of proteins. There are two major electronic characteristics of phosphorylation that aid in its detection and subsequently biosensor development: first is the release of a proton upon phosphorylation of a protein (change in pH) and second is the addition of negative charge to the protein upon its phosphorylation. The work in this thesis reports an electrolyte–insulator–semiconductor sensing structures to detect the
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43

Bell, Laurence Livingstone. "Optically interrogated biosensors in microfluidics." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610215.

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44

Zourob, Mohammed M. "Development of optical waveguide biosensors." Thesis, University of Manchester, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.743091.

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Li, Jiahao. "Heterogeneously integrated impedance based biosensors." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277259.

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The salient issues of integrated biosensors on a complementary metal-oxide semiconductor (CMOS) platform are the limited transducer design and the need for post-processing. To overcome these issues, a heterogeneously integrated system, which employs both CMOS and large-area processing, was proposed and developed. The system presented, could become a rapid, low-cost and disposable sensing platform for point-of-care applications. The heterogeneously integrated system, comprising a CMOS front-end circuit and disposable electrodes, was applied to measure the impedance of suspended DNA at different
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46

Peláez, Gutiérrez Enelia Cristina. "Nanoplasmonic biosensors for clinical diagnosis, drug monitoring and therapeutic follow-up." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672028.

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Aquesta tesi doctoral té com a objectiu el desenvolupament de diversos biosensors que operen sense necessitat de marcatge addicional basats en dispositius plasmònics òptics per a la detecció directa de medicaments o biomarcadors relacionats amb diferents malalties i que són analitzats directament en mostres humanes com plasma, sèrum, orina o esput. Aquests dispositius biosensors ofereixen un sens fi de beneficis com és la seva alta sensibilitat, facilitat d’operació, l’obtenció de dades quantitatives, detecció sense marcatge en temps real, i comunament només necessiten d’un petit volum de most
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47

Jolly, Pawan. "Oligonucleotide-based biosensors for the detection of prostate cancer biomarkers." Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.704811.

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The introduction of prostate-specific antigen (PSA) testing about 3 decades ago led to the possibility of early detection of prostate cancer (PCa). Although PSA testing reduced the mortality rate, it is also associated with high risk of over diagnosis in patients with and without PCa. Despite the current drawbacks, it would be a challenge to replace PSA testing entirely. Instead, there is a need to develop parallel testing of other potential biomarkers that can complement the results from PSA tests. To address alternative biomarker sensing, this thesis highlights on the development of oligonuc
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48

Ocaña, Tejada Cristina. "Aptasensors based on electrochemical impedance spectroscopy." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/305103.

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En els últims anys, a causa de la necessitat de diàgnostics ràpids i de millores en sensat, s’han utilitzat nous elements de reconeixement en biosensors. Un tipus d’aquests nous elements de reconeixement són els aptàmers. Els aptàmers són cadenes sintètiques de ADN o ARN les quals són seleccionades in vitro i tenen la capacitat d’unir-se a proteïnes, ions, cèl.lules, fàrmacs i lligands de baix pes molecular, reconeixent les seves molècules diana amb alta afinitat i especificitat. Diversos biosensors basats en aptàmers, també anomenats aptasensors, han sigut desenvolupats recentment. D’entre t
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Vigués, Frantzen Núria. "High-density bacterial immobilization strategies for the development of microbial biosensors." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670963.

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Els biosensors microbians són dispositius analítics que utilitzen microorganismes com elements de reconeixement. Els microorganismes s’immobilitzen a la superfície del transductor de manera que la interacció microorganisme-analit genera una senyal (electroquímica, òptica, entre altres) que pot ser quantificada. Els biosensors microbians es poden fer servir en diferents àmbits d’aplicació com al diagnòstic clínic, la indústria alimentària o la monitorització mediambiental amb l’avantatge de ser portables, simples, barats, i per tant bones alternatives als mètodes de laboratori. Desafortunadamen
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Mulcahey, Thomas Ian. "Autonomous cricket biosensors for acoustic localization." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33833.

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The goal of this project was to design networked arrays of cricket biosensors capable of localizing sources such as footsteps within dangerous environments, with a possible application to earthquake detection. We utilize the cricket's natural ability to localize low frequency (5 Hz - 600 Hz) acoustic sources using hair-covered appendages called cerci. Whereas previous investigations explored crickets' neurological response to near field flows generated by single frequency steady-state sounds, we investigated the effects of transient waveforms, which better represent real world stimuli, and to
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