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1

Howe, Daniel Steven. "A WIRELESS ELECTRICAL STIMULATION SYSTEMFOR WOUND HEALING THERAPYWITH BIPHASIC HIGH-VOLTAGE PULSED CURRENT OUTPUT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1365179992.

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Petersson, Marcus. "Computational Modeling of Deep Brain Stimulation." Thesis, Linköping University, Department of Biomedical Engineering, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9512.

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<p>Deep brain stimulation (DBS) is a surgical treatment technique, which involves application of electrical pulses via electrodes inserted into the brain. Neurons, typically located in the basal ganglia network, are stimulated by the electrical field. DBS is currently widely used for symptomatically treating Parkinson’s disease patients and could potentially be used for a number of neurological diseases. In this study, computational modeling was used to simulate the electrical activity of neurons being affected by the electrical field, to gain better understanding of the mechanisms of DBS. The
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Ly, Mai Thanh Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Electrical stimulation of cells involved in wound healing." Publisher:University of New South Wales. Graduate School of Biomedical Engineering, 2008. http://handle.unsw.edu.au/1959.4/41523.

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Problem investigated: Chronic wounds are not only a major burden to the patient arising from general pain and discomfort but also generate economic costs to both these individuals and the health care system. Various electrical stimulation regimes have been employed to study the effects of electrical stimulation on wound healing both in vivo and in vitro. In was hypothesised that electrical stimulation using various waveforms can modulate cell function, particularly cell migration. The aim of this thesis was to study the effects of electrical stimulation on cellular migration, in particular
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Hyde, Molly. "The Combined and Differential Effects of Monophasic and Biphasic Repetitive Transcranial Magnetic Stimulation on ERP-Indexed Attentional Processing in Treatment-Resistant Depression." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39932.

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In addition to low mood, major depressive disorder (MDD) is characterized by persistent cognitive deficits that impair daily functioning and resist improvement with conventional pharmacotherapies. Repetitive transcranial magnetic stimulation (rTMS) holds promise as an efficacious alternative, offering better outcomes than medication for patients with treatment-resistant depression (TRD). Yet, current rTMS protocols that administer sinusoidal biphasic pulses achieve remission in less than the majority. However, monophasic pulses may yield higher success rates based on greater cortical excitatio
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Yao, Tien Sing, and 姚天行. "Neurotic biphasic stimulation driver." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/77703033399425110847.

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Li, Jin-Wei, and 李晉緯. "An Adjustable Biphasic Pulse Electrical stimulation chip." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/wwc6yt.

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碩士<br>國立雲林科技大學<br>電子工程系<br>102<br>This study considered the specifications of electrical stimulation output current and thus used TSMC 0.25-um HV mixed signal Based BCD process to integrate a system and components used in traditional electrical stimulator into one chip. The architecture of this electrical stimulation chip contained an 8-bit digital-to-analog converter and a high-voltage driver circuit. Considering the differential nonlinearity (DNL) as well as the glitch and avoiding unnecessary waste of area, to achieve high-linearity current output, the 8-bit digital-to-analog converter was
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Chen, Gui-Rong, and 陳桂榕. "A 50mA Biphasic Pulse Stimulation Chip Using High-Voltage Process." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/41567221845096622959.

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碩士<br>國立雲林科技大學<br>電子與光電工程研究所碩士班<br>101<br>This study used TSMC 0.25-um HV mixed signal Based BCD 2.5/5/7/12/20/24/40/45/60V process to implement the Biphasic Pulse Stimulation Chip ,which aimed to reduce the large volume caused by the high-power components of booster circuit in traditional electric stimulator. In this electrical stimulator architecture, a suitable structure was planed to solve the problem with power consumption and area consumption caused by high-voltage transistors. The structure contained 8-bit high-voltage digital-to-analog converter to control any intensity of output curre
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Lu, Yi-Ching, and 盧怡晴. "A Biphasic Current Mode Functional Electrical Stimulator with A Class-AB Charge Compensation Mechanism for Deep Brain Stimulation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/4hbg44.

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碩士<br>國立臺灣科技大學<br>電機工程系<br>107<br>A current mode functional electrical stimulator(FES) with class-AB charge compensation mechanism is proposed. In the two-channel FES, a six-bit current DAC is equipped to provide the stimulation current, and the current intensity can be adjusted from 50 uA to 3 mA for animal experiments and human body use. In addition, the safety issue of the electric stimulator is also considered. Therefore, the biphasic current mode is applied to suppress the epileptic effect first by a cathodic current, and then an anodic current of the same intensity is performed for the f
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"Gamma Band Oscillation Response to Somatosensory Feedback Stimulation Schemes Constructed on Basis of Biphasic Neural Touch Representation." Doctoral diss., 2017. http://hdl.handle.net/2286/R.I.45529.

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abstract: Prosthetic users abandon devices due to difficulties performing tasks without proper graded or interpretable feedback. The inability to adequately detect and correct error of the device leads to failure and frustration. In advanced prostheses, peripheral nerve stimulation can be used to deliver sensations, but standard schemes used in sensorized prosthetic systems induce percepts inconsistent with natural sensations, providing limited benefit. Recent uses of time varying stimulation strategies appear to produce more practical sensations, but without a clear path to pursue improvemen
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Lai, Chia-Lin, and 賴佳琳. "Interaction between Peripheral Blood Monocytes (PBM) and Lymphocytes (PBLs) of Healthy Porcine Circovirus TypeⅡ (PCV2)-Carrier Pigs Following Monophasic or Biphasic Stimulation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/45755478966075571077.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>95<br>Porcine circovirus type Ⅱ (PCV2) infection has been demonstrated to be an essential factor in the induction of the newly emerged disease, postweaning multisystemic wasting syndrome (PMWS), in pigs. PCV2 antibodies have been found in pigs worldwidely, usually with high seroprevalence. Although monocyte/macrophage lineage cells are considered as the major target cells, the role of lymphocytes on the disease development is still uncertain. Immune activation and co-factors such as bacteria or viruses have been suggested to be important factors in the induction of PM
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Lai, Chia-Lin. "Interaction between Peripheral Blood Monocytes (PBM) and Lymphocytes (PBLs) of Healthy Porcine Circovirus Type2 (PCV2)-Carrier Pigs Following Monophasic or Biphasic Stimulation." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1907200718003800.

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Huang, Shih-Yun, and 黃詩芸. "The Design of 180-nm CMOS 256-Pixel Sensing and Biphasic Current Stimulation Chips with Bidirectional-Sharing Electrodes and Charge Pump for Subretinal Prosthesis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/eq66hv.

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Liao, Jung-Hsing, and 廖容興. "THE DESIGN OF 180-NM CMOS 480-PIXEL SENSING AND BIPHASIC CURRENT STIMULATION CHIPS WITH FOUR DIRECTIONAL SHARING ELECTRODES AND CHARGE PUMP FOR SUBRETINAL PROSTHESIS." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9u4376.

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碩士<br>國立交通大學<br>電子研究所<br>106<br>A photovoltaic-cell-powered CMOS 480-pixel implantable chip is proposed for subretinal prostheses. In the proposed chip, the divisional power supply scheme (DPSS) and the active pixel sensor (APS) are adopted to improve the efficiency of output stimulation currents and the image sensitivity. The proposed chip consists of totally 480 photodiode array with 32 DPSS divisions, control signal generator circuits, and photovoltaic cells. It is designed and fabricated in 180-nm CMOS image sensor (CIS) technology. The chip size is 3.1mm x 3.1mm. At first, the chip have n
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Sung, Wei-Jie, and 宋偉傑. "THE DESIGN OF 180-NM CMOS 256-PIXEL SENSING AND BIPHASIC STIMULATION CHIPS WITH ON-CHIP PHOTOVOLTAIC CELLS AND DIVISIONAL POWER SUPPLY SCHEME FOR SUBRETINAL PROSTHESES." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/gnd233.

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碩士<br>國立交通大學<br>電子工程學系 電子研究所<br>104<br>A photovoltaic-cell-powered CMOS 256-pixel implantable chip is proposed for subretinal prostheses. In the proposed chip, the divisional power supply scheme (DPSS) and the active pixel sensor (APS) are adopted to improve the efficiency of output stimulation currents and the image sensitivity. The proposed chip consists of a 16x16 photodiode array with 8 DPSS divisions, control signal generator circuits, and photovoltaic cells. It is designed and fabricated in 180-nm CMOS image sensor (CIS) technology. The chip size is 3mm x 3mm. The DPSS11 measured frequen
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Su, Chao-Kuei, and 蘇釗逵. "The design of 65-nm cmos 64-pixel sensing and biphasic stimulation chips with on-chip solar cells and divisional power supply scheme for implanted subretinal prostheses." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9tcq9r.

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碩士<br>國立交通大學<br>電子工程學系 電子研究所<br>102<br>In this thesis, a solar-cell powered CMOS current stimulation chip and an implant system for subretinal prostheses are proposed and analyzed. The chip structure is based on the proposed Divisional Power Supply Scheme (DPSS) to improve the efficiency of output stimulation current. N+/P-well photodiode structure with floating P-substrate and NMOSET in P-well with floating deep n-well (DNW) are adopted to prevent photocurrent leakage and enable CMOS devices integration in twin-well CMOS technology with DNW structure. The experimental chips consists of three
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Chang, E. Yuan, and 張峨源. "A High Energy-Efficiency, Biphasic Exponential Current Stimulator with Loading Adaptability." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/6t9upf.

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碩士<br>國立清華大學<br>電機工程學系<br>105<br>With the development of technology, Bio-medical Electrics has drawn more attention then before. Researches had shown that Functional electrical stimulation(FES) can be used to cure or replace function loss of human body and can even treat some neuron-related diseases. And thanks to the improvement of semi-conductor technology, these bio-medical devices can be integrated into small implant devices, which can replace damaged function on human body in daily life or detect and cure neuron-related problems whenever necessary. In recent years, many research groups ha
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Hsieh, Chia-Chi, and 謝佳琪. "Design of Multi-Channel Monopolar Biphasic Voltage Stimulator for Implantable Biomedical Application." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/33xrmh.

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碩士<br>國立交通大學<br>電子研究所<br>106<br>Neurological disorder causes unusual electrical activity in the brain that further affects the motor system, such as Parkinson’s disease and epilepsy, and there are seventy million population around the world suffer from these symptoms. Instead of drugs, electrical stimulation therapy has been proven to effectively restore some physical functions of patients by stimulating the abnormal nerve sites. With the development of CMOS process and bioelectronics, an implantable system-on-chip (SoC) device is able to be realized. Combing with microelectronics, medicine an
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Huang, Yu-Kai, and 黃昱凱. "Design of Four-Channel Monopolar Biphasic Current Stimulator System for Cochlear Implant Application." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/9j43d6.

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碩士<br>國立交通大學<br>電子研究所<br>108<br>With rapid development of biomedical science and semiconductor, SoC for biomimicry is becoming feasible. Cochlear implant is an implanted hearing-aid device which provides senses of sound by electrical stimulation. In this work, the stimulator system employs four electrodes placed on the surface of bone and one electrode on the round window to preserve partial hearing. The proposed circuit is capable of providing monopolar biphasic current stimulation with single-output or dual-output mode. The pulse shape and magnitude of current can be flexibly controlled by d
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Hung, Tao-Jung, and 洪道容. "Design of Monopolar Biphasic 8-channel Current and Voltage Stimulator for Parkinson\'s Disease." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/re82da.

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碩士<br>國立交通大學<br>電子研究所<br>108<br>Neuromodulation is a technique to affect nerve behavior and the device of it can be implanted in many places to treat illness such as Parkinson’s disease. Neuromodulation can be chemical or electrical. Chemical neuromodulation is to implant pharmaceutical agents to tissue. Electrical neuromodulation is to use electric to stimulate nerves. The stimulation can have two stimulation modes (voltage and current), two system configu- rations (monopolar and bipolar), and two kinds of stimulation pulses (monophasic and biphasic). This thesis proposes three monopolar
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