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Rozprawy doktorskie na temat „Blastoma”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Saathoff, Yannic [Verfasser], and Reinhard [Akademischer Betreuer] Schneppenheim. "Mutation analysis of the DICER1 gene in Pleuropulmonary Blastoma / Yannic Saathoff ; Betreuer: Reinhard Schneppenheim." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/121699823X/34.

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Gardner, Margaret A. B. S. "Cell and developmental stage specific role of Dicer1 in the lung epithelium." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427797752.

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Laplace-Builhe, Béryl. "Élucidation des bases cellulaires et moléculaires de la formation du blastème lors de la régénération épimorphique chez les vertébrés." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT023.

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Contrairement aux mammifères adultes, l’amputation d’un membre de vertébrés capables de régénérer, est suivie de la formation d’une structure hautement proliférative et hétérogène : le blastème. Les conditions de formation de ce blastème sont encore mal connues. La sécrétion de facteurs par les cellules dérivées de la crête neurale CCN, seraient à l’origine de la prolifération du blastème. De plus, les macrophages sont recrutés sur le site d’amputation et participeraient à la régénération mais leurs mécanismes d’actions et interactions avec les CCN n’ont jamais été étudiés dans ce contexte. Mo

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4

Dainese, Linda. "Caractérisation morphologique et moléculaire du néphroblastome, du blastème et de la région chromosomique 11p15 en particulier." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066738/document.

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La tumeur de Wilms (WT) est la tumeur du rein la plus fréquente chez l'enfant âgé de moins de 5 ans. Bien que la majorité des enfants avec WT soit aujourd'hui soignée, 10 à 15% rechutent. L'identification de nouveaux marqueurs pronostic au diagnostic est donc nécessaire. Nous avons centralisé le matériel biologique de toutes les WTs françaises inclus dans le protocole SIOP-2001. Le blastème, la composante histologique la plus agressive de ces tumeurs, a été caractérisé par une analyse qualitative (architecture et aspect cytologique, index mitotique et prolifératif) et quantitative (volume et p

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5

Schnapp, Esther. "Studying the Molecular Mechanisms for Generating Progenitor Cells during Tail Regeneration in Ambystoma mexicanum." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1118385281298-73348.

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The present thesis is a contribution to unravel the molecular mechanisms that underlie urodele regeneration. Urodele amphibians (newts and salamanders) are among the few vertebrates with the remarkable ability to regenerate lost body appendages, like the limbs and the tail. Urodele tail and limb regeneration occurs via blastemal epimorphic regeneration. A blastema is a mound of progenitor cells that accumulates at the amputation plane and eventually gives rise to the missing structures. It is known today that dedifferentiating muscle fibers at the amputation plane contribute to the blastema ce

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6

Betz, Georg. "Pulmonales Blastom Abgrenzung vom malignen diffusen Mesotheliom und pulmonalen Adenokarzinom /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970850182.

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7

Strauss, Bernhard. "Oriented cell divisions in the Xenopus blastula." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614211.

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8

Jansen, Steven G. "3, 2, 1 blastoff analyzing data through rocketry /." Menomonie, WI : University of Wisconsin--Stout, 2006. http://www.uwstout.edu/lib/thesis/2006/2006jansens.pdf.

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9

Corcoran, Jonathan Patrick Thomas. "Expression and regulation of newt simple epithelial keratins in the regenerating limb blastema." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362770.

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10

Meier, Lori T. "Blastoff! Social Studies as Seeds for STEM and Space Exploration." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/5897.

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11

Ma, Leung Hang. "Characterization of calcium signals during the blastula period of zebrafish (danio rerio) embryogenesis /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202007%20MA.

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12

Kragl, Martin. "Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1200413201153-65663.

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We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight into the initial steps of limb patterning. 2)We have examined the roles of different tissues regarding their fates and features of proximo- distal patterning. Our strategy was to transplant GFP+ skin, skeleton, muscle and Schwann cells from transgenic donors to limbs of wild type hosts, amputate throu

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13

Gorham, Hazel Claire. "Characterisation of a novel bacteriophage, 0BHG1, and its interactions with its host Rhodopseudomonas blastica." Thesis, University of Warwick, 1987. http://wrap.warwick.ac.uk/110014/.

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0BHG1, a lytic phage specific for Rhodopseudomonas blastica has an icosahedral head of 62 ran diameter and a short, 39 nm long, non- contractile tail with a collar, base plate and short spikes. Caesium chloride density centrifugation of phage normally gave a single phage band corresponding to a density of 1.3850 g cm, but occasionally a second band was observed (1.3838 g cm. No apparent differences were observed between the two phage bands. The nucleic acid of 0BHG1 is double stranded DNA, with a G+C content of 50.6 mol %, and a molecular weight of 48 kb. The capsid proteins are observed rangi

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14

Hill, David S. "The expression of retinoic acid receptor delta in the normal limb, regeneration blastema, and embryo of the newt, notophthalmus viridescens." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315318.

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15

Zhang, Jiao. "The role of intra- and intercellular Ca[superscript]2+ transients in the differentiation of enveloping layer cells during the blastula period of zebrafish (danio rerio) development /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202009%20ZHANG.

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16

Kragl, Martin. "Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum." Doctoral thesis, Technische Universität Dresden, 2007. https://tud.qucosa.de/id/qucosa%3A24033.

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We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight into the initial steps of limb patterning. 2)We have examined the roles of different tissues regarding their fates and features of proximo- distal patterning. Our strategy was to transplant GFP+ skin, skeleton, muscle and Schwann cells from transgenic donors to limbs of wild type hosts, amputate throu

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17

BAUD, CHRISTIANE. "Contribution a l'etude des permeabilites ioniques membranaires de l'oeuf a la blastula, par les techniques electrophysiologiques." Paris 6, 1987. http://www.theses.fr/1987PA066252.

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18

Baud, Christiane. "Contribution à l'étude des perméabilités ioniques membranaires de l'oeuf à la blastula par les techniques électrophysiologiques." Grenoble : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37593738d.

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19

Melle, Federica <1987&gt. "Il sequenziamento massivo dell'esoma rivela nuovi target molecolari nella neoplasia blastica delle cellule dendritiche plasmocitoidi (BPDCN)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7427/1/Federica_Melle.pdf.

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La neoplasia Blastica di derivazione dagli elementi Dendritici Plasmacitoidi è una rara ed aggressiva neoplasia ematologica con una prognosi sfavorevole. Non esiste un regime terapeutico standard di prima linea per questi pazienti e solo pochi studi hanno finora esplorato la genetica del BPDCN mostrando un cariotipo complesso e alterazioni genetiche sporadiche. Lo scopo del nostro studio è stato quello di indagare, mediante sequenziamento massivo, lo stato mutazionale di tutto il genoma codificante di 15 casi di BPDCN e della linea cellulare CAL-1. Sulla base di questi dati, abbiamo seguito u

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20

Melle, Federica <1987&gt. "Il sequenziamento massivo dell'esoma rivela nuovi target molecolari nella neoplasia blastica delle cellule dendritiche plasmocitoidi (BPDCN)." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7427/.

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La neoplasia Blastica di derivazione dagli elementi Dendritici Plasmacitoidi è una rara ed aggressiva neoplasia ematologica con una prognosi sfavorevole. Non esiste un regime terapeutico standard di prima linea per questi pazienti e solo pochi studi hanno finora esplorato la genetica del BPDCN mostrando un cariotipo complesso e alterazioni genetiche sporadiche. Lo scopo del nostro studio è stato quello di indagare, mediante sequenziamento massivo, lo stato mutazionale di tutto il genoma codificante di 15 casi di BPDCN e della linea cellulare CAL-1. Sulla base di questi dati, abbiamo seguito u

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21

de, León Escapini Laura Elisabeth [Verfasser]. "Molekulargenetische Charakterisierung pleuropulmonaler Blastome im Kindes- und Jugendalter mittels komparativer genomischer Hybridisierung und Fluoreszenz in-situ Hybridisierung / Laura Elisabeth de León Escapini." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1155760808/34.

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22

Wohlfahrt, Aline Bicca. "DISTINÇÃO ENTRE HEMATOGÔNIAS E BLASTOS EM PACIENTES PORTADORES DE LEUCEMIA LINFOCÍTICA AGUDA DE CÉLULAS B." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/6014.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Hematogones are B-lineage lymphoid precursors cells normally found in bone marrow. The B-cell Acute Lymphocytic Leukemia (B-ALL) is a lymphocytic precursors neoplasia with consequent accumulation of immature cells called lymphoblasts in bone marrow. The increase of hematogones after treatment for B-ALL or marrow transplantation may cause doubt to the prognosis due to morphological and immunophenotypic similarities between these normal and malignant precursors cells. The aim of this study was to differentiate subpopulations of hemat

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23

Thomka, James R. "Dynamic linkages between stratigraphy, climate, oceanography, and biotic events in the middle Silurian of eastern Laurentia." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1445342455.

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24

Matos, Jesamar Correia. "AnÃlise comparativa em histograma da intensidade de fluorescÃncia de CD10 e CD19 em blastos leucÃmicos e hematogÃnias." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4290.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>HematogÃnias sÃo cÃlulas jovens normais da medula Ãssea responsÃveis pela produÃÃo das cÃlulas de linhagem B do sistema imunolÃgico. A leucemia linfoblÃstica aguda de cÃlulas precursoras B representa um dos tipos de transformaÃÃo neoplÃsica das hematogÃnias. Devido a alta similaridade do ponto de vista citolÃgico dos dois tipos celulares, Ã possÃvel haver erros de interpretaÃÃo na anÃlise citolÃgica, fazendo-se necessÃrio em algumas circunstÃncias o uso de tÃcnicas complementares diagnÃsticas para diferenciar as cÃlulas benignas da

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25

Matos, Jesamar Correia. "Análise comparativa em histograma da intensidade de fluorescência de CD10 e CD19 em blastos leucêmicos e hematogônias." reponame:Repositório Institucional da UFC, 2005. http://www.repositorio.ufc.br/handle/riufc/1854.

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MATOS, Jesamar Correia. Análise comparativa em histograma da intensidade de fluorescência de CD10 e CD19 em blastos leucêmicos e hematogônias. 2005. 99 f. Dissertação (Mestrado em Patologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2005.<br>Submitted by denise santos (denise.santos@ufc.br) on 2011-12-21T13:48:54Z No. of bitstreams: 1 2005_dis_jcmatos.pdf: 1013012 bytes, checksum: a3d1918d6a7f051c01d35ea52491ce11 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-02-02T15:57:39Z (GMT) No. of bitstreams: 1 2005_dis_jcmatos.pdf:

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Sung, Hung-wei [Verfasser], and Herbert [Akademischer Betreuer] Steinbeisser. "The Role of Zygotic Gene Activation Controlling the Onset and Coordination of Mid-blastula Transition / Hung-wei Sung ; Betreuer: Herbert Steinbeisser." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/117922938X/34.

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Gasparelo, Tatiane Aparecida Canhamero. "Estudo dos mecanismos genéticos e celulares durante a fase inflamatória do processo de regeneração tecidual em animais selecionados geneticamente para a máxima resposta inflamatória aguda homozigotos para os alelos R ou S do gene Slc11a1." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-03022010-093331/.

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Sublinhagens de camundongos AIRmax e AIRmin homozigotas para os alelos R ou S do gene Slc11a1 apresentam distinta capacidade regenerativa à perfuração de suas orelhas. Animais AIRmaxSS exibiram regeneração tecidual precoce em comparação aos animais AIRmaxRR, sugerindo que o alelo S favorece a regeneração nestes animais. Camundongos das sublinhagens AIRmin não apresentaram regeneração após perfuração de suas orelhas. Em resposta ao estímulo, animais AIRmaxSS exibiram inflamação local mais intensa e tardia do que animais AIRmaxRR, demonstrando elevados níveis de MPO e edema, e influxo celular pr

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28

Tawk, Marcel. "Étude d'un gène hsp40 au cours de la régénération de la nageoire caudale et du développement embryonnaire chez le poisson zèbre (Danio rerio)." Paris 7, 2002. http://www.theses.fr/2002PA077182.

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Jawhari, Soha. "Etude des signalisations autophagique et neurotrophique dans des lignées de glioblastome humain activées lors de l’hypoxie." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0022/document.

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Le glioblastome multiforme (GBM) est la tumeur cérébrale la plus fréquente et la plus agressive. Il s’agit d’une tumeur capable de survivre même dans des conditions d’oxygénation faible ou hypoxie. En effet, les cellules cancéreuses du GBM activent des voies de survie en réponse à cette privation de dioxygène, dont l’autophagie. Il s’agit d’un mécanisme catabolique conduisant à la dégradation des constituants cellulaires, générant ainsi des précurseurs pour l’anabolisme cellulaire ainsi que de l’ATP. Nous avons étudié l’activation de l’autophagie en réponse à l’hypoxie, dans trois lignées cell

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Delfini, Marcello. "Jun regulates monocyte-derived macrophage accumulation and tumour progression." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0076.

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Les macrophages sont des cellules immunitaires innées présentes dans chaque organe. Ils sont des cibles thérapeutiques dans de nombreuses maladies, dont le cancer. En dépit de travaux récents sur l'origine des macrophages, les mécanismes régulant leur différenciation sont mal définis. L'expression de Jun, membre de la famille AP-1, augmente pendant la différenciation des macrophages, mais son rôle dans ce processus n'est pas connu.Au cours de mon doctorat, nous avons caractérisé le rôle de Jun dans le développement et l'homéostasie des macrophages, dans un modèle de souris avec délétion condit

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Rönsch, Kathleen. "Patterning of stem cells during limb regeneration in Ambystoma mexicanum." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232386.

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Axolotl uniquely generates blastema cells as a pool of progenitor/stem cells to restore an entire limb, a particular property that other organisms, such as humans, do not have. What underlies these differences? Is the main difference that cells residing at the amputation plane (in the stump) undergo reprogramming processes to re-enter the embryonic program, which allows developmental patterning to start, or are there fundamental differences? There is also a significant debate about whether regeneration occurs via stem cell differentiation or by dedifferentiation of mature limb tissue. The aim

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32

Marchesi, Raquel Ferrari. "Anemia aplástica adquirida - avaliação da biópsia de medula óssea na identificação de prognóstico desfavorável, aferido pela evolução para SMD/LMA: um estudo comparativo em crianças e adultos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-08052018-121635/.

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Anemia aplástica adquirida (AAA) é doença rara e seu diagnóstico diferencial inclui a Síndrome mielodisplásica hipocelular (SMD-h). A evolução de AAA para SMD/LMA (Síndrome mielodisplásica/Leucemia mieloide aguda) ocorre em até 15% dos casos. Este estudo propõe-se a comparar parâmetros histológicos e imuno-histoquímicos de pacientes adultos e crianças com AAA que evoluíram e não para SMD/LMA. Seu objetivo é avaliar a ocorrência dos critérios morfológicos/imunofenotípicos nas biópsias de medula óssea do grupo pediátrico (<19 anos) com o grupo de adultos, comparar esses critérios associados à ev

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Tornini, Valerie Angela. "Clonal Analysis of the Zebrafish Fin Regeneration Blastema." Diss., 2016. http://hdl.handle.net/10161/13389.

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<p>Regeneration is a remarkable feat of developmental regrowth and patterning. The blastema is a mass of progenitor cells that enables complete regeneration of amputated salamander limbs or fish fins. Despite years of study, methodologies to identify and track blastemal cell progenies have been deficient, restricting our understanding of appendage regeneration at a cellular and molecular level. To bridge this knowledge gap, gene expression analysis, the generation of transgenic and mutant zebrafish, qualitative and quantitative analyses, morphological measurements, and chemical treatments were

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Guimond, Jean-Charles. "Analyse fonctionnelle du gène BMP-2 lors de la régénération du membre chez l’axolotl." Thèse, 2010. http://hdl.handle.net/1866/4699.

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Les amphibiens urodèles (e.g. les axolotls) possèdent la remarquable capacité de régénérer plusieurs parties de leur corps. Ils peuvent, entre autres, régénérer parfaitement un membre amputé par épimorphose, un processus biphasique comprenant une phase de préparation, spécifique à la régénération, et une phase de redéveloppement, commune à l’épimorphose et au développement embryonnaire. Durant la phase de préparation, les cellules du moignon se dédifférencient en cellules pseudo-embryonnaires, prolifèrent et migrent distalement au plan d’amputation pour former un blastème de régénération. Parm

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Betz, Georg [Verfasser]. "Pulmonales Blastom : Abgrenzung vom malignen diffusen Mesotheliom und pulmonalen Adenokarzinom / vorgelegt von Georg Betz." 2003. http://d-nb.info/970850182/34.

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Valenti, Fabio. "Study on b-Catenins mechanisms of regulation in zebrafish blastula embryo." Doctoral thesis, 2012. http://hdl.handle.net/10447/94635.

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Background: â-catenin is a central component of the cadherin cell adhesion complex but also it plays an essential role in the canonical-Wingless/Wnt signaling pathway. In vertebrates, one of the initial steps for the establishment of the correct dorso-ventral (D/V) pattern in the embryo is the cytoplasmic accumulation followed by nuclear localization of â-catenin in the cells of the prospective dorsal side of the embryo. In zebrafish there are two â-catenins, 92,7% identical. The mutant fish line Ichabod (ich), with a mutation in the region of the â-catenin2 promoter that causes a decr

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Dexter, Troy A. "Mechanisms for increasing respiratory capacity through ontogeny in the blastoid genus pentremites." 2006. http://etd.utk.edu/2006/DexterTroy.pdf.

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Lee, Yoonsung. "Regulation of Progenitor Cell Proliferation During Zebrafish Fin Regeneration." Diss., 2009. http://hdl.handle.net/10161/1345.

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<p>Vertebrates like urodele and teleost have an enhanced capacity for regeneration, when compared to mammals. Recently, the teleost zebrafish (Danio rerio) has become a popular model for studying regenerative events, due to the ability to regenerate multiple organs such as the fin and the heart, and the diverse genetic approaches available for functional studies. In my thesis studies, I have used the zebrafish caudal fin as a model system to understand molecular and cellular mechanism of appendage regeneration. </p><p>Pharmacological and genetic studies have revealed that Fgf signaling is im

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"Bone Marrow-derived Cells Contribute To Multilineage Reconstitution And Blastema Stage-specific Upregulation Of A Transient Scaffold In Regenerating Mouse Digit Tips." Tulane University, 2014.

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In 2005, 1.6 million Americans lived with a debilitating amputation and this figure is predicted to double by 2050. But the ability of a mammal to recapitulate a complex limb structure is not impossible. Evidence of children and mice re-growing digit tips following amputation midway through the terminal phalanx (P3) exists. The hallmark of this phenomenon is development of a blastema housing undifferentiated cells capable of being re-programmed to replicate the missing part. Our central goal is to understand specific components of this process for application into pro-scarring injuries. The mo

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40

Delorme, Stephanie. "Scar-free wound healing and regeneration in the leopard gecko (Eublepharis macularius)." Thesis, 2011. http://hdl.handle.net/10214/3095.

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Scar-free wound healing and regeneration are uncommon phenomena permitting the near complete restoration of damaged tissues, organs and structures. Although rare in mammals, many lizards are able to undergo scarless healing and regeneration following loss of the tail. This study investigated the spontaneous and intrinsic capacity of the leopard gecko (Eublepharis macularius) tail to undergo scar-free wound healing and regeneration following two different forms of tail loss: autotomy, a voluntary and evolved mechanism of tail shedding at fracture planes; and surgical amputation, involuntary lo

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Krupa, Magdalena. "Determinacja losów blastomerów podczas formowania się pierwszych linii komórkowych w zarodku myszy." Doctoral thesis, 2016.

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Rozdzielenie populacji komórek zewnętrznych i wewnętrznych, będących prekursorami odpowiednio trofektodermy (TE) i węzła zarodkowego (ICM) w zarodku myszy, ma miejsce w trakcie trzech tur asymetrycznych podziałów blastomerów w stadium 8-, 16- i 32-komórkowym. W ICM dochodzi następnie do wyodrębnienia komórek pierwotnej endodermy (PE) oraz epiblastu (EPI). Celem niniejszej rozprawy była odpowiedź na pytanie, jakie czynniki determinują różnicowanie tych linii komórkowych w przedimplantacyjnym zarodku myszy.W CZĘŚCI 1. mojej pracy analiza ekspresji genów specyficznych dla EPI i PE w pojedynczych

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Rönsch, Kathleen. "Patterning of stem cells during limb regeneration in Ambystoma mexicanum." Doctoral thesis, 2017. https://tud.qucosa.de/id/qucosa%3A30743.

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Axolotl uniquely generates blastema cells as a pool of progenitor/stem cells to restore an entire limb, a particular property that other organisms, such as humans, do not have. What underlies these differences? Is the main difference that cells residing at the amputation plane (in the stump) undergo reprogramming processes to re-enter the embryonic program, which allows developmental patterning to start, or are there fundamental differences? There is also a significant debate about whether regeneration occurs via stem cell differentiation or by dedifferentiation of mature limb tissue. The aim

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