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Rozprawy doktorskie na temat „Blood – Coagulation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Gray, E. "Lipoproteins, blood coagulation and thrombosis." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372834.

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The main aim of this study was to investigate the involvement of plasma lipoproteins in the blood coagulation system and the implications of this relationship in the pathogenesis of thrombosis. This study has shown that lipid peroxide-induced thrombin generation is caused by a two-fold mechanism: direct interaction of lipid peroxides with lipoprotein phospholipids and inhibition of anti-thrombin III via its heparin-binding site. Experiments using purified lipoproteins have shown that triglyceride-rich lipoproteins, i.e. chylomicra and very low density lipoproteins, are sources of procoagulant

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2

Sowedan, Ahmed M. "Rheometrical study of blood coagulation." Thesis, Swansea University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678535.

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3

Perdomo, Joana L. "Mathematical Modeling of Blood Coagulation." Scholarship @ Claremont, 2016. https://scholarship.claremont.edu/hmc_theses/71.

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Blood coagulation is a series of biochemical reactions that take place to form a blood clot. Abnormalities in coagulation, such as under-clotting or over- clotting, can lead to significant blood loss, cardiac arrest, damage to vital organs, or even death. Thus, understanding quantitatively how blood coagulation works is important in informing clinical decisions about treating deficiencies and disorders. Quantifying blood coagulation is possible through mathematical modeling. This review presents different mathematical models that have been developed in the past 30 years to describe the biochem

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4

Ramström, Sofia. "The role of platelets in whole blood coagulation /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med776s.pdf.

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5

Tate, Geoffrey Michael. "The blood coagulation mechanism and hypercoagulability." Thesis, University of Leeds, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281131.

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6

Tosenberger, Alen. "Blood flow modelling and applications to blood coagulation and atherosclerosis." Doctoral thesis, Institut Camille Jordan, CNRS UMR 5208, Université Claude Bernard Lyon 1, Université Claude Bernard Lyon 1, France, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/244806.

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7

Fung, Marion R. "Molecular genetics of blood coagulation factor X." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28783.

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Thirty thousand colonies of a bovine liver cDNA library were screened with a mixture of synthetic oligodeoxyribonucleotides coding for bovine factor X. Five positive colonies were identified, and plasmid DNA was isolated. Cleavage with restriction endonucleases showed that these plasmids (designated pBXl-5) contained inserts of 1530 bp, 770 bp, 700 bp, 1100 bp and 930 bp. DNA sequence analysis of the plasmid with the largest insert (pBXl) confirmed that bovine factor X cDNAs had been cloned. The cDNA sequence predicts that factor X is synthesized as a single chain precursor in which the light

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8

Sarphie, Anna Frances. "Changes in blood coagulation associated with hyperlipidaemia." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319009.

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9

Smith, Brian. "Protein models in blood coagulation and fibrinolysis." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239327.

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10

Head, Denise Marie. "Pharmacological modulation of the blood coagulation cascade." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298832.

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11

Hobby, Deanna Jeanne. "A COMPARISON OF ACTIVATED PARTIAL THROMBOPLASTIN TIME OBTAINED BY TWO TECHNIQUES IN PATIENTS FOLLOWING PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/291339.

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A descriptive study was conducted to test the null hypothesis: There will be no statistically significant difference between serum activated partial thromboplastin time (aPTT) obtained by two methods; venipuncture and large bore femoral arterial catheter. The convenience sample consisted of seventeen adults who had undergone percutaneous transluminal coronary angioplasty (PTCA) for the treatment of coronary artery disease. After the PTCA procedure, patients returned to an intensive care unit with a femoral intra-arterial catheter in place. Seventeen pairs of serum samples were obtained; one by

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12

He, Shu. "Hypercoagulation in preeclampsia : implications for maternal health and foetal growth /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3647-1/.

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13

Eriksson-Berg, Margita. "Hemostasis in middle-aged women with coronary heart disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-978-1/.

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14

Lindoff, Claes. "Haemostasis during pregnancy and perimenopausal age studies of fibrinolytic components and coagulation factors involved in vascular disease /." Lund : Dept. of Obstetrics and Gynaecology, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39750405.html.

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15

Soons, Johannes Wilhelmus Pieter Hubertus. "Studies on the inhibition of blood coagulation factor XIa." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1987. http://arno.unimaas.nl/show.cgi?fid=5391.

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16

Nguyen, Vina, and Vina Nguyen. "Microfluidic Paper Analytic Device for Assessment of Blood Coagulation." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/624139.

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Monitoring blood coagulation while a patient is on cardiopulmonary bypass (CPB) is critical in preventing clots from arising in the bypass machine and consequently being sent into the patient’s bloodstream. Current methods used to monitor blood coagulation such as Activated Clotting Time (ACT) yield results that do not correlate coagulation time to heparin or protamine dosage and will typically take at least 400 s to yield a result that is safe to initiate bypass. Microfluidic paper-based analytical devices (μPAD) are advanced sensors based on a wide range of recently developed techniques for

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17

Ruttmann, Thomas Gotthard. "The effect of in vitro haemodilution on coagulation." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26986.

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18

Goldenberg, Neil A. "Development of the clot formation and lysis (CloFAL) global assay and its application to the investigation of bleeding disorders in children and adults /." Connect to abstract via ProQuest. Full text is not available online, 2008. http://proquest.umi.com/pqdweb?did=1545571881&sid=1&Fmt=2&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Clinical Science) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 136-146). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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19

Davidson, Colin John. "Molecular evolution of haemostasis." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368908.

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20

Jones, D. W. "Factor XII and antiphospholipid antibodies." Thesis, University of Kent, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311229.

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21

Sargeant, Paul. "Calcium signalling in human platelets : stored-regulated calcium entry." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318268.

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22

Thomas, Stephen. "Antithrombotic agents under flow conditions." Thesis, Open University, 2003. http://oro.open.ac.uk/54153/.

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Haemostasis is the result of a fine balance of interactions between the endothelium, plasma proteins and blood cells under a wide range of flow rates. To mimic these conditions in vitro, a parallel plate flow chamber with human umbilical vein endothelial cells (HUVEC) or extracellular matrix (ECM) has been developed. A method to investigate thrombin generation (TG) in platelet rich defibrinated plasma was validated and used to investigate inhibition by two distinct classes of antithrombotic agents: anti-platelet antibodies and anticoagulants, including unfractionated heparin (UFH), low molecul

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23

Ungerstedt, Johanna S. "Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-477-1/.

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24

Jesting, Amalie. "Evaluation of prolonged surface activated coagulation time." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-27144.

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Background: Blood coagulation is an essential defense mechanism to prevent bleeding. Disorders in the coagulation system can be severe and blood tests measuring the blood’s ability to coagulate are important. Activated partial thromboplastin time (APTT) is a blood test that measures blood coagulation time. An abnormal prolonged APTT can both be associated with a bleeding tendency or a risk of thrombosis. Additional blood tests are needed to discover the cause of a prolonged APTT. One potential test is the APTT mixing study, which can separate samples with and without inhibitors. The aim of thi

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25

Matata, Bashir Mnene. "Blood response to biomaterials : in vitro and clinical investigation of the contact phase of blood coagulation." Thesis, University of Strathclyde, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297340.

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26

Rathete, Sello Athlone. "A comparative study on the effects of stress on some aspects of in vitro blood coagulation in two freshwater fish species." Thesis, University of Limpopo, 1993. http://hdl.handle.net/10386/2092.

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27

Carlsson, Karin. "Tissue Factor in Complex : Studies of interactions between blood coagulation proteins." Doctoral thesis, Linköpings universitet, Biokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-63688.

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Many biological processes rely on specific protein-protein interactions, for example immune responses, cell signaling, transcription, and blood coagulation. Blood coagulation is initiated when a vessel wall is damaged, exposing tissue factor (TF) to the circulating factor VII/factor VIIa (FVII/FVIIa) which results in the formation of the TF:FVIIa complex and thereby the initiation of blood coagulation. One of the substrates for the TF:FVIIa complex is factor X (FX), which is activated to factor Xa (FXa), subsequently leading to a series of reactions resulting in clot formation. Tissue factor p

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28

Ariëns, Robert Anton Sybrand. "The tissue factor pathway of blood coagulation in health and disease." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5931.

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29

Bakker, Harm Marten. "Accelerin the activated form(s) of human blood coagulation factor V /." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=6954.

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30

Humphries, Petro. "Effects of aspartame on the blood coagulation system of the rabbit." Thesis, University of Pretoria, 2007. http://upetd.up.ac.za/thesis/available/etd-05162008-162042.

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31

Brown, Anthony James Moginie. "Studies of the molecular structures of the blood coagulation fibrinolytic proteins." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294268.

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32

Magwenzi, Simbarashe G. "Roles of coagulation factor XIII in the functions of blood platelets." Thesis, University of Hull, 2011. http://hydra.hull.ac.uk/resources/hull:5785.

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Activated blood coagulation factor XIII (FXIIIa) is a transglutaminase that stabilises fibrin clots and associates with platelets. In the present study, the role of factor XIII (FXIII) in modulating physiological platelet functional responses including adhesion, signal transduction and spreading were examined. Under static conditions, platelets adhered to surface-immobilised plasma-purified and recombinant human FXIII leading to the formation of filopodia and lamellipodia. Adhesion to FXIIIa was mediated through integrin-dependent mechanisms, since it was abolished by treatment with RGDS. More

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33

Li, Hua. "Qualitative Blood Coagulation Test Using Paper-Based Microfluidic Lateral Flow Device." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406810864.

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34

Barton, Jennifer Kehlet. "Predicting dosimetry for laser coagulation of in vivo cutaneous blood vessels /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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35

Boys, C. W. G. "X-ray studies on bovine prothrombin : The structure of bovine prothrombin fragment 1." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382485.

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36

Thiemermann, Christoph. "Endothelium-derived mediators and the control of the vascular system." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293312.

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37

Evington, J. R. N. "Protein-polysaccaride interactions and the catalysis of the thrombin/antithrombin reaction." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370826.

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38

Apap-Bologna, Angela. "Conformational studies of fibrinogen and its derivatives." Thesis, University of St Andrews, 1988. http://hdl.handle.net/10023/14957.

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There is much controversy regarding the conformation of fibrinogen. Several models have been proposed ranging from a trinodular arrangement to a globular conformation. It has also been suggested that fibrinogen has a flexible structure where the shape of the molecule is influenced by its environment, one major factor being calcium concentration, In addition, although the importance of tightly bound calcium ions (kd 1M) to the fibrinogen molecule is well established, the role of the larger number of low affinity sites (kd 1mM) is still a matter of some debate. In this study, the two techniques

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39

Kajs, Marylyn. "A COMPARISON OF COAGULATION VALUES OBTAINED BY TRADITIONAL VENIPUNCTURE AND INTRA-ARTERIAL LINE METHODS IN ADULT PATIENTS." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275285.

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40

Fall, Lewis. "Redox regulation of haemostasis : modulation by inspiratory hypoxia and physical exercise." Thesis, University of South Wales, 2012. https://pure.southwales.ac.uk/en/studentthesis/redox-regulation-of-haemostasis-modulation-by-inspiratory-hypoxia-and-physical-exercise(712686ec-639c-4d2f-b779-47e1b3b21da1).html.

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Introduction: Haemostasis is the arrest of bleeding. In recent years, in-vitro studies have suggested that secondary haemostasis (blood coagulation) is subject to activation by reactive oxygen species (ROS). It is known that patients who suffer from vascular disease are typically hypoxaemic and in the case of peripheral occlusive artery disease (POAD), physical exercise is used to improve symptom free mobility in the affected limbs. Hypoxia and physical exercise are two potent independent and synergistic initiators of ROS. We identified a clear need for in-vivo analysis of this novel area of r

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41

Sweeney, Robin Emily, and Robin Emily Sweeney. "Biosensors for Blood and Infection Analysis." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626360.

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Three major topics will be discussed in this dissertation. The first is an optical biosensor for specific diagnosis of bacterial skin and wound infection, followed by a paper microfluidic assay and accompanying monitoring device for monitoring blood coagulation and determining patient-specific heparin and protamine dosing. The final work to be discussed is ongoing work involving the detection of circulating tumor cells (CTCs) using a paper microfluidic detection platform. All of these works involve the development of biosensors for the simultaneous advancement and simplification of diagnosis

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42

Alnsour, Hamza Mohammad Khaleel. "Role of the blood clot stabilization in early bone regeneration and osseointegration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46960399.

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Background: Blood clot formation is one of the first events in bone regeneration and osseointegration. The blood clot adheres to dental implants with hydrophilic surfaces more favorably than to those with hydrophobic surfaces. This appears to result in better bone healing and bone fill of defects around dental implants. Objective: To assess the impact of blood clot stabilization at modSLA titanium implants on bone formation in chronic-type defects in a dog model. Material & methods: Ten modSLA implants were installed in 5 dogs after creation of saddle-type buccal-lingual bony defects. I

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43

Hornsey, Valerie Scott. "Studies on monoclonal antibodies to Von Willebrand factor and coagulation factor VIII." Thesis, Heriot-Watt University, 1988. http://hdl.handle.net/10399/972.

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44

CAMPOS, LUCELIA de A. "Isolamento e caracterização da delta toxina do veneno de Crotalus durissus terrificus." reponame:Repositório Institucional do IPEN, 2006. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11452.

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Made available in DSpace on 2014-10-09T12:52:03Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:57:51Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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45

Ansari, Mohammed Toseef. "Changes in coagulation, fibrinolysis, and endothelial perturbation markers in the lower limb venous blood associated with prolonged cramped sitting in healthy adult male volunteers in a simulation of prolonged travel." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31556991.

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46

Holland, Susan Katrina. "X-ray studies of proteins of medical and biological interest." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236327.

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47

Martin, David Michael Alan. "Structure function studies on the tissue factor/factor VIIa complex." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321656.

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48

Krailadsiri, Pranee. "Microvesicles in platelet concentrates for transfusion." Thesis, Open University, 2000. http://oro.open.ac.uk/58061/.

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The key objective of this study was to examine whether leucocyte depletion generated or removed platelet-derived microvesicles in platelet concentrates for transfusion. Three in-process leucocyte removal filters for pooled buffy coat derived platelet concentrates, i. e. negative charged polyester, positively charged polyester, and non-charged polyurethane, were compared. The effects of three major leucocyte depletion technologies currently in use in the UK, i. e. Cobe LRS and Haemonetics MCS+ LD apheresis, and filtration of pooled buffy coat derive platelets, on platelet microvesiculation were

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49

Hirbawi, Jamila. "Cofactor control of a vital enzymatic reaction the effect of factor Va on thrombin formation during blood coagulation /." Cleveland, Ohio : Cleveland State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1260910688.

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Thesis (Ph.D.)--Cleveland State University, 2009.<br>Abstract. Title from PDF t.p. (viewed on Jan. 13, 2010). Includes bibliographical references (p. 124-131). Available online via the OhioLINK ETD Center and available in print.

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50

Thorelli, Elisabeth. "Pro- and anticoagulant activities of factor V." Lund : Dept. of Clinical Chemistry, Malmö University Hospital, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945027.html.

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