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Rozprawy doktorskie na temat „Blood – Diseases”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Segura, Castell Mónica. "Peripheral blood biomarkers in Psychiatric Diseases." Doctoral thesis, Universitat Internacional de Catalunya, 2012. http://hdl.handle.net/10803/83727.

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Actually, there is a strong incidence of psychiatric diseases, representing a 13% of total burden diseases and 450 million of people affected. The etiology of psychiatric diseases remains unknown. However, scientific evidences suggest a maldevelopment of nervous system (NS). The diagnosis is inaccurate, and international manuals (ICD-10 and DSM-IV) identify pathologies according to a list of symptoms but no underlying biological cause of disease. The aim of the thesis is to identify potential biomarkers -related to the development of NS- in peripheral blood of psychiatric patients diagnosed as

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2

Breen, Michael. "Blood-based biomarkers in psychiatric diseases." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/401201/.

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Identification of blood-based biomarkers for psychiatric disease risk and development has emerged as an important area of translational research in medicine, offering a means to supplement or replace current interview-based me thods for psychiatric diagnosis. The aim of this thesis is to assess the utility of genome-wide blood transcriptome profiling for the prediction, diagnosis and treatment of patients with psychiatric diseases. Some parts of this work are of a more methodological nature and geared towards the discovery of blood-based biomarkers and gene networks, while others consider mech

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3

Meister, Sabrina [Verfasser]. "Blood-CNS barriers in neurodegenerative diseases / Sabrina Meister." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/107232167X/34.

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4

TANG, YANG. "BLOOD GENOMIC FINGERPRINTS OF NEUROLOGICAL DISEASES - MICROARRAY STUDIES." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1035831350.

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5

Tang, Yang. "Blood genomic fingerprints of neurological diseases microarray studies /." Cincinnati, Ohio : University of Cincinnati, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1035831350.

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6

Yu, Xiaohong, and 于曉紅. "Hemodynamic analysis of blood flows in carotid bifurcations." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3864700X.

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7

Zalewska, Kasia. "Circulating blood immunophenotyping and metabolite profiling in pulmonary vascular diseases." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/111768/.

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Pulmonary hypertension is an abnormal physiological state associated with a variety of medical conditions. However, the ability to accurately phenotype disease subtypes within this heterogeneous syndrome is limited. In this thesis, I utilised advanced phenotyping techniques, guided by pathophysiological processes known to be dysregulated in pulmonary vascular diseases; immunity and metabolism. I used flow cytometry based immunophenotyping to study circulating leukocyte subpopulations and metabolomic analysis to study metabolite profiles in circulating blood. I hypothesised that there would be

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8

Douglas, Alexander D. "Developing novel blood-stage malaria vaccines." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:7ca728f5-6b5e-4f59-ae4b-dd81c8d9e2e8.

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Natural exposure to Plasmodium falciparum’s asexual blood-stage results in protection against severe disease, but no vaccine using the widely-studied blood-stage antigens apical membrane antigen 1 (AMA1) or merozoite surface protein 1 (MSP1) has proven convincingly protective in clinical trials. Challenges include antigenic polymorphism, the apparent requirement for exceptionally high antibody concentrations for protection, and clinical-grade production of conformationally-accurate recombinant protein antigens followed by formulation with a human-compatible adjuvant. This thesis describes the

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9

Myers, Daniel. "The Role of Osteopontin in Vascular Remodeling." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/MyersDL2004.pdf.

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10

Chopra, M. S. "Some biochemical aspects of blood in rheumatoid arthritis and vascular diseases." Thesis, University of Strathclyde, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381360.

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11

Edwards, Jane C. "Investigation of disease associated prion protein in blood from sheep naturally infected with scrapie." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559024.

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12

Thwaites, Richard Mark. "Molecular studies on the variability and basis of pathogenicity of vascular bacterial pathogens of Musa spp." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325011.

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13

Shanbhag, Preeti Pandurang. "Role of Mechanical Versus Humoral Effects of Angiotensin II on Vascular Remodeling." Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/10446.

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In this study, we investigated the role of Ang II in pathological vascular remodeling. We sought to determine whether the humoral or the mechanical effects of Ang II are the dominant factor driving the remodeling process. The following experimental groups were used: control group (untreated mice), mice treated with an angiotensin receptor blocker (Candesartan, 0.5 mg/kg/day,SQ), an ACE inhibitor (Captopril, 6 mg/kg/day), and a calcium-channel blocker (Amlodipine, 7.5 mg/kg/day). All mice (n=6 per experimental group) were from the C57Bl/6 background. The carotid ligation model was implemen

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14

Ong, Patricia Mei Lin. "Pathophysiology of acute intermittent porphyria." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318116.

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15

Gerometta, Michael. "The production and application of bispecific conjugates for the rapid diagnosis of disease in whole blood." Thesis, Queensland University of Technology, 1993. https://eprints.qut.edu.au/107090/1/T%28S%29%2019%20The%20production%20and%20application%20of%20bispecific%20conjugates%20for%20the%20rapid%20diagnosis%20of%20disease%20in%20whole%20blood.pdf.

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This thesis provides the first description of the formation and purification of Fab-peptide conjugates applied to the detection of HIV -1 and HIV -2 antibodies, in a novel, autologous red cell agglutination immunoassay. A new method was also developed for the large-scale production and purification of bispecific antibodies, which were used for the detection of heartworm antigen in dogs and cats. The conjugation method for both forms of bispecific conjugate involved blocking the hinge sulphydryls of an Fab' antibody fragment with 5,5'dithiobis(2-nitrobenzoic acid), DTNB, followed by the additio

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16

Aronson, Ingrid. "The cytopenias in systemic lupus erythematosus." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/26344.

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17

Kuhle, Jens. "Towards quantifying axonal damage in blood samples from patients with neurological diseases." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9085.

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Reliable biomarkers of axonal damage are urgently needed in neurological diseases. Neurofilaments (Nf) are specific structural elements of neurons composed of at least three subunits: Nf light chain (NfL), Nf medium and Nf heavy chain (NfH). This PhD aimed to characterise NfL levels and their correlation with clinical features in patients with neurological diseases with a different rate of progression and following and under different treatment regimes. An important aim was also to develop a bioassay for NfL measurements in blood. Cerebrospinal fluid (CSF) NfL levels discriminated patients wit

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18

Waller, Karen. "Infectious diseases in solid organ donation and transplantation." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29196.

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Solid organ transplantation is a rare health intervention that saves lives, improves quality of life and, where there is an alternative such as dialysis, is cost-effective. However, organ transplantation is a complex intervention that is limited by the number of organ donors, and requires life-long immunosuppression of the recipient. Infections are a common complication of organ transplantation, and a major cause of death for transplant recipients. Donor-derived infections, while rare, are of particular concern for transplant clinicians, as a potentially avoidable consequence of transplantatio

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19

Asare, Adam L. "Improving clinical hematopathology quality using decision support methods." Free to MU Campus, others may purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3052142.

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20

Cape, Edward Gene. "Theoretical and experimental analysis of intracardiac jets : new techniques for noninvasive quantification of valvular insufficiency." Diss., Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/11310.

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21

Kalla, Rahul. "Biomarker discovery in inflammatory bowel diseases." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31040.

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There is an unmet need for novel biomarker discovery in Inflammatory Bowel Diseases (IBD) to aid clinical management in several clinical settings including diagnosis and prognosis. With an ever-advancing repertoire of biological therapies on the horizon, it is important to personalise treatments at an early stage. The aim of this thesis is to explore the clinical utility of novel blood-based biomarkers in diagnosis, disease classification and prognosis in 2 cohorts: newly diagnosed IBD and acute severe colitis. Investigating the circulating methylome, 290 probes exhibited Holm significant IBD-

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22

Svensson, Per. "Blood pressure, blood pressure variability and myocardial ischemia : studies in patients with peripheral arterial disease and matched control subjects /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-826-2.

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23

Mok, Mo-yin, and 莫慕賢. "Endothelial dysfunction and vascular disease in systemic sclerosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46448147.

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24

Aspholm, Marina. "Adaptation of Helicobacter pylori adherence properties in promotion of host tropism and inflammatory diseases /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-388.

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25

Partanen, Taina A. "Lymphatic vs blood vascular endothelial growth factors and receptors in human tissues and diseases." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/partanen/.

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26

Goudy, Sean T. "Optimization of total cavopulmonary connection using geometry as the major." Thesis, Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/11105.

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27

Guenet, Frederique S. A. "Quantification of valvular regurgitation by proximal isovelocity surface area and magnetic resonance imaging." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/11207.

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28

De, Souza Melissa. "Central circulatory adaptations to low and high intensity cycling in patients with chronic obstructive pulmonary disease (COPD)." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84021.

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Chronic obstructive pulmonary disease (COPD) is characterized by an expiratory flow limitation, as well as an evident reduced exercise capacity compared to that of healthy age-matched individuals. Clearly, the expiratory flow limitation plays a significant role in this exercise intolerance; however, the extent of the contributions of other systemic factors remains unclear. More specifically, there is little data thus far on the role of blood flow delivery as a possible exercise limitation in COPD, especially in light of the potential interactions between cardiac output (Qc) and pulmonar

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29

Sayer, Avan Aihie. "Aging and its relationship to early growth." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242108.

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30

Mkandla, Zibusiso. "Platelet function and activation in mixed ancestry subjects with hyperglycemia, from the Western Cape, South Africa." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2258.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2016.<br>Type 2 diabetes mellitus (T2DM) is a metabolic disorder which is characterised by insulin resistance, defective insulin secretion or both. The chronic state of hyperglycemia in diabetes is associated with microvascular complications and macrovascular complications which account for an estimated 80% of deaths as a result of cardiovascular complications. Type 2 diabetes mellitus is an inflammatory disease and pro- inflammatory stimuli in the form of activated endothelial cells, render the vascular endothel

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31

Luk, Ting-hin, and 陸庭軒. "Effect of cardiac rehabilitation on vascular function in patients withcoronary artery disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153000.

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32

Turnbull, Fiona. "Effects of different blood pressure-lowering regimens on major cardiovascular events in major patient subgroups." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28142.

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Background Cardiovascular disease is a leading cause of mortality and morbidity worldwide. Blood pressure is the single, most important risk factor for cardiovascular disease; nearly two-thirds of all strokes and approximately half of all ischaemic heart disease events are attributable to non-optimal blood pressure. The evidence from individual randomised trials of blood pressure lowering regimens suggests that that protection from major cardiovascular events can be achieved by lowering blood pressure, even among those with so-called ‘normal’ blood pressures. However, many trials are no

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33

Lilliehöök, Inger. "Studies of blood eosinophil and neutrophil granulocytes in healthy and diseased dogs /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5409-3.pdf.

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34

Zheng, Leiya. "The mechanisms of autohaemotherapy with heat, oxygen/ozone and ultraviolet treated blood in vascular diseases." Thesis, Sheffield Hallam University, 1995. http://shura.shu.ac.uk/20598/.

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In the last three decades, autohaemotherapy with blood treated with oxygen containing low concentrations of ozone, either alone or in combination with an elevated temperature and ultraviolet irradiation (HOU), has been used in Europe for the treatment of peripheral vascular diseases. Many apparently widely differing beneficial claims have been made for this therapeutic approach. This study has provided an objective rationale as to how HOU-treated blood administered as autohaemotherapy may work as a therapeutic agent. This study has investigated the effect of the treatment of blood in vitro wit

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35

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies." Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb578.pdf.

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"May 2002" Includes bibliographical references (leaves 229-251) Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.

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36

Li, Yali. "DETECTING ASSOCIATION OF COMMON AND RARE VARIANTS WITH COMPLEX DISEASES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270176845.

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37

Collins, Patrick William Hugh. "Assessing the severity of lower limb ischaemia and the thrombo-inflammatory response to surgery and exercise in peripheral arterial disease." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted contains 3rd party material and therefore cannot be made available electronically until Jan. 1, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=53369.

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Thesis (M.D.)--Aberdeen University, 2008.<br>With: Surgical revascularisation in patients with severe limb ischaemia induces a pro-thrombotic state / P. Collins ... et al. Platelets. 2006: 17(5), 311-317. With: A preliminary study on the effects of exercising to a maximum walking distance on platelet and endothelial function in patients with intermittent claudication / P. Collins ... et. Eur. J. Vasc. Endovasc. Surg. 2006: 31, 266-273. Includes bibliographical references.

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38

Tian, Xiaoyu. "Mechanisms underlying mesenteric ischemia/reperfusion induced intestinal dysmotility." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/898.

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39

Moore, Vivienne M. "Fetal growth and cardiovascular risk factors in an Australian cohort /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phm824.pdf.

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40

Khan, Hassan. "Markers of glycaemia and risk of cardiovascular disease." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648585.

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41

Hong, Say Yenh. "Fluid structure interaction modeling of pulsatile blood flow in serial pulmonary artery stenoses." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112571.

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Motivated by the physiological phenomena of collapse and flow limitation for a serial pulmonary artery stenosis, we investigated the three-dimensional influence of spatial configuration on the wall motion and hemodynamic. Our numerical study focused on the effect of two geometrical parameters: the relative distance and the angular orientation between the two stenoses. The collapse of a compliant arterial stenosis may cause flow choking, which would limit the flow reserve to major vital vascular beds such as the lungs, potentially leading to a lethal ventilation-perfusion mismatch. Flow through

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42

Daniel, Rhonda W. "Dysregulation of microRNAs in Blood as Biomarkers for Diagnosing Prostate Cancer." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3975.

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Prostate cancer is the most common noncutaneous cancer among men, yet current diagnostic methods are insufficient and more reliable diagnostic markers need to be developed. The answer that can bridge this gap and enable more efficient diagnoses may lie in microRNAs. These small, single stranded RNA molecules impact protein expression at the translational level and regulate important cellular pathways. Dysregulation of these small RNA molecules can have tumorigenic effects on cells and lead to many types of cancers. Currently the Prostate-Stimulating Antigen (PSA) is used as a diagnostic marker

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43

Rajendran, senthilkumar. "STUDIES ON LINEAGE SHIFT RESPONSES OF HUMAN PERIPHERAL BLOOD MULTIPOTENT CELLS." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423582.

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Stem cell therapy is gaining momentum as an effective treatment strategy for degenerative diseases. As embryonic stem cells pose a lot of ethical issues, adult stem cells, isolated from various sources like cord blood, bone marrow or adipose tissue, are being considered as a realistic option due to their well documented therapeutic potentials. In our lab, we have standardised a method to isolate fibroblastic multipotent stem cells (PBMCs) from human peripheral blood, that are able to sustain long term in vitro culture and differentiate towards adipogenic, chondrogenic and osteogenic lineage.

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44

Newsome, Dominique. "My story, my identity and my relationship with work : sickle cell disorder." Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/14924/.

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This study explored the narratives people living with sickle cell disorder construct to explain how the experience of employment influences their identity and subsequently their quality of life. Nine individuals with sickle cell disorder were interviewed and gave detailed autobiographical narratives which were transcribed and processed using narratives analysis. Participants were 4 men and 5 women aged between 22 and 60 years. Participants' passion for their job roles was illustrated by their positive work identities. Earlier experiences were felt to be influential on drive and resilience to w

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45

Scheepers, Elrien. "The haematological kinetics of canine babesiosis in South Africa." Diss., Electronic thesis, 2008. http://upetd.up.ac.za/thesis/available/etd-07162008-132522/.

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46

Wilson, Stephanie Helen. "Pathogenesis and treatment of cholesterol-related early vascular injury." Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/28453.

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This thesis describes studies into the pathogenesis of Cholesterol—related early vascular injury. In addition, this thesis examines the potential reversibility of this injury with 2 agents: a) simvastatin, an HMGCoA reductase inhibitor, in a model independent of any reduction in lipids and 2) high dose aspirin. Hypercholesterolaemia led to a decrease in NO bioavailability, in association with a decrease in the enzyme, endothelial nitric oxide synthase and increased oxidative stress. In addition, there was an increase in the pro—inflammatory transcription factor, NF—KB, in the intima o

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47

FOLGOSI, CORREA MELISSA S. "Caracterização das flutuações do sinal doppler do fluxo microvascular." reponame:Repositório Institucional do IPEN, 2011. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10032.

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Made available in DSpace on 2014-10-09T12:34:00Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:01:05Z (GMT). No. of bitstreams: 0<br>Tese (Doutoramento)<br>IPEN/D<br>Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP

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48

Murchie, Karen J. (Karen Jo) 1973. "Arterial function in hypertension and heart failure." Monash University, Faculty of Medicine, 2000. http://arrow.monash.edu.au/hdl/1959.1/8884.

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49

Böhm, Marlies. "The comparative assessment of capillary and venous Babesia rossi parasitaemias on thin blood smears and their association with disease manifestation." Electronic thesis, 2006. http://upetd.up.ac.za/thesis/available/etd-05042007-154527/.

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50

Ensley, Ann Elizabeth. "A fluid mechanic assessment of the total cavopulmonary connection." Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/15724.

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