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1

Moroz, Adam. "Reduced order modelling of bone resorption and formation." Thesis, De Montfort University, 2011. http://hdl.handle.net/2086/5409.

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The bone remodelling process, performed by the Bone Multicellular Unit (BMU) is a key multi-hierarchically regulated process, which provides and supports various functionality of bone tissue. It is also plays a critical role in bone disorders, as well as bone tissue healing following damage. Improved modelling of bone turnover processes could play a significant role in helping to understand the underlying cause of bone disorders and thus develop more effective treatment methods. Moreover, despite extensive research in the field of bone tissue engineering, bonescaffold development is still very
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Lean, Jennifer Maree. "Mechanical stimulation of bone formation in the rat." Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263682.

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Miao, Dengshun. "Studies on the actions of bone anabolic drugs in vivo and in vitro." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300362.

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Althnaian, Thnaian Ali. "Factors that regulate osteoclast formation and bone resorption in regenerating deer antlers." Thesis, Royal Veterinary College (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439832.

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Davey, Tamara. "Functional characterisation of a novel osteoclast-derived factor." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0219.

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[Truncated abstract] Intracellular communication between osteoclasts and osteoblasts is imperative to maintain bone integrity. A myriad of molecules are responsible for regulating osteoblast and osteoclast activity. In particular, it is well documented that osteoblast-derived factors are crucial in directly controlling osteoclast formation and function. Since bone formation is coupled to bone resorption, it would be expected that osteoclasts also have some role in regulating the growth and function of osteoblast cells. However, despite extensive research upon osteoclast and osteoblast biology,
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Loomer, Peter Michael. "The direct effects of Porphyromonas gingivalis 2561 on bone formation and mineral resorption in vitro." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27685.pdf.

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Owens, Beatrice H. "Dose-dependent effects of salmon calcitonin on bone turnover in ovariectomized rats." [Johnson City, Tenn. : East Tennessee State University], 2004. http://etd-submit.etsu.edu/etd/theses/available/etd-1120104-223525/unrestricted/OwensB120204f.pdf.

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Thesis (Ph.D.)--East Tennessee State University, 2004.<br>Title from electronic submission form. ETSU ETD database URN: etd-1120104-223525 Includes bibliographical references. Also available via Internet at the UMI web site.
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Kassem, Ali. "Toll-like receptors (TLRs) and inflammatory bone modeling." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110296.

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Patients with inflammatory or infectious conditions such as periodontitis, peri-implantitis, osteomyelitis, rheumatoid arthritis, septic arthritis and loosened joint prosthesis display varying severity of destruction in the adjacent bone tissue. Bone loss in inflammatory diseases is considered a consequence of cytokine induced RANKL and subsequent enhanced osteoclast formation. Hence, osteotropic cytokines and their receptors have been suggested to be important for the pathogenesis of inflammation-induced osteolysis. It is, here, suggested that bacterial components, so called “pathogen associa
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9

Lotz, Ethan M. "Designing Biomimetic Implant Surfaces to Promote Osseointegration under Osteoporotic Conditions by Revitalizing Mechanisms Coupling Bone Resorption to Formation." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5908.

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In cases of compromised bone remodeling like osteoporosis, insufficient osseointegration occurs and results in implant failure. Implant retention relies on proper secondary fixation, which is developed during bone remodeling. This process is disrupted in metastatic bone diseases like osteoporosis. Osteoporosis is characterized low bone mass and bone strength resulting from either accelerated osteoclast-mediated bone resorption or impaired osteoblast-mediated bone formation. These two processes are not independent phenomena. In fact, osteoporosis can be viewed as a breakdown of the cellular com
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Mbimba, Thomas S. Jr. "TRAFICKING PROTEIN PARTICLE COMPLEX (TRAPPC) -9:A NOVEL PROTEIN REGULATOR OF NF-kB MEDIATED BONE FORMATION AND RESORPTION." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1448841594.

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Tai, Victoria. "The effects of leukotriene B¦4 on osteoclast formation and osteoclastic bone resorption and the role of osteoblastic cells in these processes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ28805.pdf.

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Antunes, Antonio Azoubel. "Tratamento de defeitos ósseos cervicais com materiais osseocondutores porosos imediatamente à instalação de implantes: estudo histológico, histométrico, micro-tomográfico e de análise de frequência de ressonância em cães." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/58/58136/tde-03102013-112834/.

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O objetivo do presente estudo foi comparar a eficácia da implantação de biomateriais porosos na neoformação óssea e reparo de defeitos cervicais mandibulares em cães, com ou sem a técnica de regeneração óssea guiada (ROG). Bio-Oss Block® (BB), Bio-Oss Collagen® (BC), Bio-Oss® em grânulos (BG), osso autógeno (Ab) e coágulo (Cg) foram utilizados nas mesmas situações experimentais. Para o grupo com membrana foi utilizado o BioGide®. Doze cães foram submetidos a extrações dos pré-molares e primeiros molares mandibulares bilateralmente. Quatro meses após cinco defeitos ósseos (6 mm de diâmetro/4 mm
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Terndrup, Haley Frances, Alison K. Ventura, Todd Hagobian, and Scott Hazelwood. "THE EFFECTS OF A UNIFORMLY WEIGHTED EXERCISE SUIT ON BIOMARKERS OF BONE TURNOVER IN RESPONSE TO AEROBIC EXERCISE IN POSTMENOPAUSAL WOMEN WITH LOW BONE DENSITY." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1637.

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Current options for maintaining or slowing aging-related bone mineral density (BMD) loss in postmenopausal women primarily include pharmaceutical agents. More recently, physical activity and exercise have been suggested as highly effective, low cost alternatives. Weighted aerobic exercise, utilizing load carriage systems (LCS), is known to increase the gravitational forces impacting bone, creating a higher osteogenic stimulus than standard aerobic exercise. In response to the positive research on aerobic exercise with well-designed LCS, Dr. Lawrence Petrakis, MD, developed a unique 5.44 kg uni
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14

Huang, Mei Yueh, and 黃美月. "Effects of Interleukin-1 on Bone Formation and Bone Resorption." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/07163209475470901384.

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碩士<br>國防醫學院<br>解剖學研究所<br>82<br>The purposes of this study were:1)to establish an in vitro model of bone formation, 2)to investigate the effects of interleukin-1(IL-1 )on bone formation,3)to establish an in vitro bioassay of osteoclast formation and 4)to clarify the effects of IL-1 on bone resorption. Thirteen-fourteen day BALB/C fetal calvarial cells were obtained and cultured for 3 weeks.With light microscopic observation, quantitation of bone colony and alkaline phosphata
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Huang, Chun-Huang, and 黃駿煌. "Effects of bone resorption, bone formation, and immune tolerance on the development of Taiwanese ankylosing spondylitis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/59749297306165297493.

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博士<br>中山醫學大學<br>醫學研究所<br>101<br>Ankylosing spondylitis (AS) is a chronic inflammatiory disorder. Inflammation has been reported to promote the differentiation and maturation of the osteoclast, and bone resorption also affects the overexpression of the osteoblast resulting in the bone formation and syndesmophyte. In addition, imbalance of autoimmune tolerance is associated with the occurrence of autoimmune diseases. The higher expression of CD4+ and CD8+ T cells has also been found in AS patients than in healthy controls, and such expression may relate to the imbalance in the negative signal of
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Alsendi, Maryam Abdulaziz. "The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone." Thesis, 2020. https://hdl.handle.net/2144/41342.

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OBJECTIVE: To determine the effect of anti-inflammatory drugs (4- methoxybenzophenone) and (kavain) on bone formation and bone resorption models using a three-dimensional (3D) live calvarial bone METHODS: Utilizing neonatal mouse calvarial bones on a grid system with media designed to cause bone formation or resorption. These models were used to study the effect of 4- methoxybenzophenone and kavain on bone remodeling. The spent media were evaluated by quantitative analysis of tartrate resistant acid phosphatase (TRAP), alkaline phosphatase (ALP) activity and calcium release. The calvaria we
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"Epimedium Active Component Icaritin Enhances Bone Mass through Regulating the Coupling of Bone Formation and Resorption Mediated by Distinct Signaling Targets." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292649.

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Sardone, Laura Donata. "The Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis." Thesis, 2010. http://hdl.handle.net/1807/25786.

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Rosiglitazone (RSG) is an insulin-sensitizing drug used to treat Type 2 Diabetes Mellitus (T2DM). Clinical trials show that women taking RSG experience more limb fractures than patients taking other T2DM drugs. The purpose of this study is to understand how RSG (3mg/kg/day and 10mg/kg/day) and the bisphosphonate alendronate (0.7mg/kg/week) alter bone quality in the male, female and female ovariectomized (OVX) Zucker fatty rat model over a 12 week period. Bone quality was evaluated by mechanical testing of cortical and trabecular bone. Microarchitecture, bone mineral density (BMD), cortical bo
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