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Rozprawy doktorskie na temat „Boron-neutron capture therapy”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 28 lipca 2024

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1

Howard, William Bruce. "Accelerator-based boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/44479.

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Hefne, Jameel. "Neutron spectrum measurement for Boron Neutron Capture Therapy." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16625.

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3

Goorley, John Timothy 1974. "Boron neutron capture therapy treatment planning improvements." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49670.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1998.<br>Includes bibliographical references.<br>The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations were the most time consuming aspect of the treatment planning process, requiring more than thirty six hours for scoping calculations of three to five beams and final calcu

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4

Matalka, Khalid Zuhair. "Boron neutron capture therapy of brain tumors /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148778039326795.

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5

Guidi, Claretta. "Sviluppo e applicazioni della boron neutron capture therapy." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13399/.

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La Boron Neutron Capture Therapy è una tecnica terapeutica altamente selettiva, utilizzata in oncologia, che si basa sulla reazione di cattura neutronica 10B(n,α)7Li . Tale selettività è garantita dal maggior assorbimento di boro, tramite specifici veicolanti, da parte delle cellule tumorali rispetto alle cellule sane, che si mantengono inalterate. I prodotti della reazione di cattura sono particelle ad alto LET, quindi poco penetranti, e questo consente un rilascio energetico letale per i tessuti malati. L'obiettivo di questa tesi è fornire un quadro generale sulla Boron Neutron Capture The

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6

Shah, Jungal (Jugal Kaushik). "Hypoxia-selective compounds for boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44829.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2008.<br>"June 2008."<br>Includes bibliographical references.<br>Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal cells. A general problem with the tumor seeking compounds is that drug delivery is dependent upon sufficient vascularization within the tumor. To

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7

Wang, Zhonglu. "Design of a Boron Neutron Capture Enhanced Fast Neutron Therapy Assembly." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14100.

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A boron neutron capture enhanced fast neutron therapy assembly has been designed for the Fermilab Neutron Therapy Facility (NTF). This assembly uses a tungsten filter and collimator near the patient¡¯s head, with a graphite reflector surrounding the head to significantly increase the dose due to boron neutron capture reactions. The assembly was designed using Monte Carlo radiation transport code MCNP version 5 for a standard 20x20 cm2 treatment beam. The calculated boron dose enhancement at 5.7-cm depth in a water-filled head phantom in the assembly with a 5x5 cm2 collimation was 21.9% per 100

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8

Sweezy, Jeremy Ed. "Development of a boron neutron capture enhanced fast neutron therapy beam." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/17107.

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9

Kudchadker, Rajat. "Optimized accelerator based epithermal neutron beams for boron neutron capture therapy /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821332.

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10

Chung, Yoonsun. "Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44784.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2008.<br>Includes bibliographical references (p. 123-132).<br>This thesis evaluates the radiobiological effectiveness of three new boron compounds namely a boronated porphyrin (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and boronophenylalanine (BPA). In vitro evaluations utilized a colorimetric assay and 96-well plates to minimize the quantities of compound requ

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11

GASPAR, PRISCILA de F. "Consideracoes sobre o estudo da BNCT (Terapia de captura neutronica por boro)." reponame:Repositório Institucional do IPEN, 1994. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10384.

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Made available in DSpace on 2014-10-09T12:38:03Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:46Z (GMT). No. of bitstreams: 1 05585.pdf: 4329322 bytes, checksum: 1e4698a5a96c7426a7fe1f3b5bc39703 (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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12

Bosko, Andrey. "General Electric PETtrace cyclotron as a neutron source for boron neutron capture therapy." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/2606.

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This research investigates the use of a PETtrace cyclotron produced by General Electric (GE) as a neutron source for boron neutron capture therapy (BNCT). The GE PETtrace was chosen for this investigation because this type of cyclotron is popular among nuclear pharmacies and clinics in many countries; it is compact and reliable; it produces protons with energies high enough to produce neutrons with appropriate energy and fluence rate for BNCT and it does not require significant changes in design to provide neutrons. In particular, the standard PETtrace 18O target is considered. The cyclotron e

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13

Ghani, Zamir. "The physics, dosimetry and microdosimetry of boron neutron capture therapy." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4000/.

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A validated experimental and numerical procedure is described detailing macroscopic and microscopic dose calculations forming the basis of a protocol for the pre-clinical biological characterisation of the University of Birmingham’s BNCT facility. Fundamental reference dosimetric measurements have been carried out at the University of Birmingham’s accelerator based NCT facility and the Massachusetts Institute of Technology (MIT) research reactor to characterise macroscopic and microscopic doses and derive correction factors for the irradiation of V79 cells incubated in boric acid and irradiate

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14

Phoenix, Ben. "Synergistic and dose rate effects in Boron Neutron Capture Therapy." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4084/.

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An investigation of the factors affecting the biological effectiveness of neutron beams suitable for Boron Neutron Capture Therapy (BNCT) has been carried out. The primary experimental work described in this thesis concerns the degree of interaction, if any, between biological damage caused by low LET radiation and that caused by high LET radiation. The second area investigated concerns the biological impact of delivering a BNCT irradiation at differing dose rates. In mixed photon alpha particle irradiations, no synergistic effect was observed above the response from the separate components. M

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15

Kiger, Jingli Liu. "Radiobiology of normal rat lung in Boron Neutron Capture Therapy." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/41286.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2006.<br>Includes bibliographical references.<br>Boron Neutron Capture Therapy (BNCT) is a binary cancer radiation therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal rat lung in BNCT and measured the relative biological effectiveness factors for the lung. Rat thorax irradiations were carried out with x-rays and neutrons

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16

Pitto-Barry, Anaïs. "Polymers and boron neutron capture therapy(BNCT): a potent combination." Royal Society of Chemistry, 2021. http://hdl.handle.net/10454/18415.

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Yes<br>Boron neutron capture therapy (BNCT) has a long history of unfulfilled promises for the treatment of aggressive cancers. In the last two decades, chemists, physicists, and clinical scientists have been coordinating their efforts to overcome practical and scientific challenges needed to unlock its full therapeutic potential. From a chemistry point of view, the two current small-molecule drugs used in the clinic were developed in the 1950s, however, they both lack some of the essential requirements for making BNCT a successful therapeutic modality. Novel strategies are currently used to d

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17

Ceberg, Crister. "Pharmacokinetics and biodistribution of boron compounds foundations for boron neutron capture theory /." Lund : Dept. of Radiation Physics, Lund University, 1994. http://books.google.com/books?id=wnhrAAAAMAAJ.

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18

Mitchell, Hannah Elizabeth. "An accelerator-based epithermal photoneutron source for boron neutron capture therapy." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16345.

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19

Frixa, Christophe. "Boronated tetraphenylporphyrins for use in boron neutron capture therapy of cancer." Thesis, University of Bath, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268747.

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20

Kortesniemi, Mika. "Solutions for clinical implementation of boron neutron capture therapy in Finland." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/fysik/vk/kortesniemi/.

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21

Dobelbower, Michael Christian. "An integrated design of an accelerator-based neutron source for boron neutron capture therapy /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu148794815862645.

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22

Brown, Adam Vernon. "Development of a high-power neutron producing [lithium] target for boron neutron capture therapy." Thesis, University of Birmingham, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761253.

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23

Basak, Prakitri. "Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy and synthesis of 2,3-dideoxy-2,3-methanoribofuranoside glycosyl donors and a study of their use in stereocontrolled glycosylation reactions." Columbus, OH : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1041010809.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 279 p.: ill. (some col.). Includes abstract and vita. Advisor: Todd L. Lowary, Dept. of Chemistry. Includes bibliographical references (p. 150-154).

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24

Ishikawa, Masayori. "Development of New Absorbed Dose Estimation System for Boron Neutron Capture Therapy." Kyoto University, 2002. http://hdl.handle.net/2433/149649.

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25

Ledesma, Michelle N. (Michelle Nicole) 1975. "Medical room design for a fission converter-based boron neutron capture therapy facility." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50533.

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26

Qu, Tanxia. "A Monte Carlo design study of an accelerator epithermal neutron irradiation facility for boron neutron capture therapy /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487844105974799.

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27

Schmitz, Tobias [Verfasser]. "ESR-dosimetry in thermal and epithermal neutron fields for application in Boron Neutron Capture Therapy / Tobias Schmitz." Mainz : Universitätsbibliothek Mainz, 2016. http://d-nb.info/1112150870/34.

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28

Todd, Jean Ann. "Platinum(II) complexes containing 1,2- and 1,7-carborane ligands for boron neutron capture therapy." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09pht634.pdf.

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29

Alfuraih, Abdulrahman. "Exploring the use of high energy medical linear accelerator in boron neutron capture therapy." Thesis, University of Surrey, 2009. http://epubs.surrey.ac.uk/843807/.

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Boron Neutron Capture Therapy (BNCT) is based on the nuclear reaction that occurs when 10B loaded tissue is irradiated with thermal neutron yielding high linear energy transfer alpha particles and recoiling 7Li nuclei. Neutron sources for BNCT are currently limited to research nuclear reactors. However most reactors are not in close proximity to hospitals and their use for clinical trials can be difficult. High energy photon beams from medical Linear accelerators produce undesirable neutrons, beside the clinically useful electron and photon beams, neutrons are produced from the photonuclear re

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30

Liu, Liang. "Development and Evaluation of Boron Targeting Agents For Neutron Capture Therapy of Brain Tumors /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487932351057135.

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31

Woollard, Jeffrey E. "Optimization of a moderator assembly for use in an accelerator-based neutron source for boron neutron capture therapy /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945744571817.

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32

Klee, Kathleen A. "Optimization of an Epi-thermal neutron beam and beam dosimetry for boron neutron capture therapy at the Georgia Tech Research Reactor." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/16405.

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33

Olusanya, Temidayo Olajumoke Bolanle. "Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer." Thesis, University of Portsmouth, 2015. https://researchportal.port.ac.uk/portal/en/theses/formulation-and-preliminary-evaluation-of-delivery-vehicles-for-the-boron-neutron-capture-therapy-of-cancer(595b381c-50cc-4a49-9c20-4850a01a43f1).html.

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Boron neutron capture therapy (BNCT) is a method for selectively destroying malignant (normally glioma) cells whilst sparing normal tissue. Irradiation of 10B (large neutron capture cross-section) with thermal neutrons effects the nuclear fission reaction: 10B + 1n → → 7Li+ + α + γ; where the penetration of -particles and 7Li+ is only 8 and 5 μm, respectively, i.e., within a single cell thickness, assuming 10B can be preferentially located within glioma cells. Poor selectivity is the main reason why BNCT has not become a mainstream cancer therapy. Carboranes. a third generation of high boron

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34

Calabrese, Gianpiero. "Design, synthesis and preliminary in vitro evaluation of potential agents for Boron Neutron Capture Therapy." Thesis, University of Portsmouth, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478899.

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35

Gao, Wei Ph D. "Lithium-6 filter for a fission converter-based Boron Neutron Capture Therapy irradiation facility beam." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34653.

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Includes bibliographical references (p. 164-165).<br>Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2005.<br>(cont.) A storage system was designed to contain the lithium-6 filter safely when it is not in use. A mixed field dosimetry method was used to measure the photon, thermal neutron and fast neutron dose. The measured advantage depth is 9.3 ± 0.1cm without filter and 9.9 ± 0.1cm with 8mm lithium-6 filter. The result is consistent with the result of Monte Carlo calculation.<br>The design of a lithium-6 filter to be used in Boron Neutron Capture Therapy w

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36

Ko, Naonori. "Establishment of quality assurance and quality control measures for Boron Neutron Capture Therapy using microdosimetry." Kyoto University, 2020. http://hdl.handle.net/2433/253277.

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37

Suzuki, Minoru. "The effects of boron neutron capture therapy on liver tumors and normal hepatocytes in mice." Kyoto University, 2001. http://hdl.handle.net/2433/150526.

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38

Luguya, Raymond Joseph. "Syntheses of novel porphyrin, chlorin, and corrole macrocycles for application in boron neutron capture therapy and photodynamic therapy /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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Thesis (Ph. D.)--University of California, Davis, 2005.<br>Degree granted in Chemistry. Dissertation completed in 2004; degree granted in 2005. Also available via the World Wide Web. (Restricted to UC campuses).

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39

Byun, Youngjoo. "Thymidine kinase as a molecular target for the development of novel anticancer and antibiotic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149008350.

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40

Gupta, Nilendu. "Fabrication and preliminary testing of a moderator assembly for an accelerator-based neutron source for boron neutron capture therapy /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487867541731792.

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41

Rogus, Ronald D. (Ronald Daniel). "Design and dosimetry of epithermal neutron beams for clinical trials of boron neutron capture therapy at the MITR-II reactor." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/12280.

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42

Wang, Chang-Kwang Chris. "A pilot study of an epithermal neutron source based on a low-energy proton accelerator for boron neutron capture therapy /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672631600438.

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43

White, Susan Marie 1973. "Beam characterization for accelerator-based boron neutron capture therapy using the ⁹Be(d,n) nuclear reaction." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50491.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1998.<br>Includes bibliographical references (leaves 62-65).<br>Use of the ⁹Be(d,n) nuclear reaction for accelerator-based boron neutron capture therapies (AB-BNCT) was investigated. The moderated neutron spectra produced at several deuteron bombarding energies were evaluated in terms of dose rates and dosimetric profiles in a water-filled brain phantom using an existing heavy water moderator and lead reflector assembly. Dosimetry results were obtained using the dual ionization chamber technique coupled with ba

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44

Ryynänen, Päivi. "Kinetic mathematical modesl for the 111In-labelled bleomycin complex and 10B in boron neutron capture therapy." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/fysik/vk/ryynanen/.

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45

Niemkiewicz, John. "A study on the use of removal-diffusion theory to calculate neutron distributions for dose determination in boron neutron capture therapy /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487934589976468.

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46

MAGNI, CHIARA. "Experimental and computational studies for an Accelerator-Based Boron Neutron Capture Therapy clinical facility: a multidisciplinary approach." Doctoral thesis, Università degli studi di Pavia, 2022. http://hdl.handle.net/11571/1447823.

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The work described in this thesis has been carried out in the field of AB-BNCT, Accelerator-Based Boron Neutron Capture Therapy. BNCT is a binary radiotherapy combining the enrichment of tumour with boron-10 and its subsequent irradiation with low energy neutrons, exploiting the high cross section of neutron capture in boron-10. With a selective accumulation of boron-10 in the tumour by a suitable borated drug, the products of the reaction release a therapeutic dose in the tumour while sparing the surrounding healthy tissues. This biological selectivity makes BNCT a promising therapy for the

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47

MANGUEIRA, THYAGO F. "Avaliacao dosimetrica da solucao fricke gel usando a tecnica de espectrofotometria para aplicacao na dosimetria de eletrons e neutrons." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9447.

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Made available in DSpace on 2014-10-09T12:26:53Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:00:05Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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48

Roux, Lionel. "Conception et synthèse d'inhibiteurs de l'Aminopeptidase membranaire N ([EC. 3.4.11.2], APN ou CD13)." Thesis, Mulhouse, 2010. http://www.theses.fr/2010MULH4691/document.

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La lutte contre le cancer est l'un des défis majeurs du XXème siècle. Pour que les tumeurs puissent se développer dans l'organisme, elles ont besoin d'un apport en nutriment par le biais de vaisseaux sanguins pour se faire, elles vont avoir recours au processus angiogénique. Lors de ce processus, les cellules endothéliales qui tapissent la paroi des vaisseaux sanguins vont se multiplier et créer de nouveaux vaisseaux sanguins qui vont permettre la vascularisation des tumeurs. L'angiogenèse constitue donc aujourd'hui un axe de recherche pour la lutte contre la progression tumorale et donc contr

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49

Sakamoto, Shuichi. "Sensitivity studies of the neutronic design of a fission converter-based ephithermal beam for boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/46089.

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Gibson, Christopher R. "Pharmacokinetics, metabolism, and dose optimization simulation studies of Sodium Borocaptate for Boron Neutron capture therapy of Malignant Gliomas /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu148639916010674.

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