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Artykuły w czasopismach na temat „Bras humain”

Autor: Grafiati

Data publikacji: 25 maja 2024

Data aktualizacji: 31 lipca 2025

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1

Burdet, E. "Un Modele Connectionniste du Regulateur Adaptatif du Bras Humain." Archives of Physiology and Biochemistry 103, no. 3 (1995): C110. http://dx.doi.org/10.3109/13813459509037324.

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AWO, A. Dieudonné, and Eunock ODJOUMANI. "Les fermes royales de palmiers à huile dans la stratégie de reconversion économique du royaume du Danxomè au XIXe siècle." NTELA, Revue du Centre Universitaire de Recherche sur l'Afrique 2, no. 1 (2025): 37–60. https://doi.org/10.55595/3t9g9t92.

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Le royaume du Danxomè connut une vie économique rythmée par l’évolution de l’économie-monde. Dans le cadre du capitalisme mercantile (XVIe-XIXesiècle), il fournit quinze millions de bras valides aux plantations et aux mines américaines. Ce commerce du "bétail humain" l’enrichit de biens de prestige, d’armes de défense et de moyens financiers qui le hissèrent au rang des plus puissants États du golfe du Bénin que les révolutions industrielles (1830-1890) obligèrent à une reconversion économique. Cette étude vise à déterminer la place des fermes royales de palmiers à huile dans la reconversion é

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Lee, Seong-Ho, Jihye Lee, Darshika Amarakoon, et al. "Tumor Suppressive Activity of High Phenolic Sorghum Brans in Colon Cancer Mouse Model and Proposed Mechanisms." Current Developments in Nutrition 4, Supplement_2 (2020): 329. http://dx.doi.org/10.1093/cdn/nzaa044_028.

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Abstract Objectives Colon cancer occupy third rank in the United States and its incidence is inversely associated with high consumption of plant-based diet including whole grains. Sorghum is one of broadly cultivated crops and the bran of sorghum contains high content of bioactive compounds including polyphenols. The current study was designed to examine if different type of high phenolic sorghum brans (PI570481, SC84 and Sumac) suppress tumor formation in genetic colon cancer mouse model and elucidate related biochemical and molecular mechanisms using human colon cancer cells. Methods Fifty-t

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Meziani, Samira, Souad Saidani, Lahouaria Labga, Rawda Benguella, and Imene Bekhaled. "Bioactive compounds and antioxidant potential of soft wheat and oat bran on the Algerian market." North African Journal of Food and Nutrition Research 4, no. 7 (2020): 245–51. http://dx.doi.org/10.51745/najfnr.4.7.245-251.

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Background: Rich in dietary fibers and beneficial to health, wheat and oats have been a popular part of the human diet. The whole grain is rich in protein, lipid, starch and phenolic compounds concentrated at the level of the peripheral layer of the bran. Aims: The natural compounds and the antioxidant potential of two different species of soft wheat and oat bran on the Algerian market have been studied in this work. Wheat bran was furnished by Azzouz’s Cereal and Dried Vegetable Cooperative (CCLS) being the most commercialized oat bran in Algeria. Material and Methods: Some parameters and bra

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Meziani, Samira, Souad Saidani, Lahouaria Labga, Rawda Benguella, and Imene Bekhaled. "Bioactive compounds and antioxidant potential of soft wheat and oat bran on the Algerian market." North African Journal of Food and Nutrition Research 04, no. 07 (2020): 245–51. https://doi.org/10.5281/zenodo.3754224.

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<strong>Background</strong>: Rich in dietary fibers and beneficial to health, wheat and oats have been a popular part of the human diet. The whole grain is rich in protein, lipid, starch and phenolic compounds concentrated at the level of the peripheral layer of the bran. <strong>Aims: </strong>The natural compounds and the antioxidant potential of two different species of soft wheat and oat bran on the Algerian market have been studied in this work. Wheat bran was furnished by Azzouz’s Cereal and Dried Vegetable Cooperative (CCLS) being the most commercialized oat bran in Algeria.<stron

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6

John, N. Kinyuru, C. Borresen Erica, and P. Ryan Elizabeth. "Nutritional and Safety Evaluation of Heat-Stabilized Rice Bran for Supplementary Feeding of Malnourished Children in Kenya." International Journal of Food Science, Nutrition and Dietetics 4, no. 6 (2015): 226–32. https://doi.org/10.19070/2326- 3350-1500041.

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Rice bran is a by-product of rice milling that has been primarily used in animal feed negating its potential for human consumption. The aim of this study was to evaluate the application of rice bran to aid in managing infant and childhood malnutrition. Rice bran samples were collected from Kenya (Mwea) and U.S. (RiBran 300, RiceBran TechnologiesTM) for nutritional, heavy metals and microbial analysis. Reference values for rice bran from the USDA nutrient database were included for comparison. Additionally, seven supplementary foods containing maize, soya bean, rice bran and suga

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Bras, Pierre-Louis, and Isabelle Bridenne. "Entretien avec Pierre-Louis Bras." Retraite et société N°83, no. 3 (2019): 165. http://dx.doi.org/10.3917/rs1.083.0166.

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Maksymowicz, Agata, and �ucja Kapralska. "AKTYWNO�� JAKO STRATEGIA POMY�LNEGO STARZENIA SI� W �WIETLE INTERNETOWYCH RAD I WSKAZ�WEK DLA SENIOR�W." Studia Humanistyczne AGH 22, no. 2 (2023): 29–46. http://dx.doi.org/10.7494/human.2023.22.2.29.

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Niniejsza praca dotyczy zagadnienia organizacji czasu wolnego os�b przebywaj�cych na emeryturze. Kolejny etap �ycia po zako�czeniu pracy niesie za sob� brak obowi�zk�w zawodowych i powolne wycofywanie si� z pe�nionych dot�d r�l spo�ecznych. Stan ten z jednej strony mo�e by� b�ogos�awie�stwem, z drugiej powodowa� uczucie pustki i stres z powodu tak nadmiaru czasu wolnego, jak i konieczno�ci przystosowania si� do nowej sytuacji. St�d pytanie: co robi� na emeryturze, by przeciwdzia�a� wspomnianym powy�ej stanom i zjawiskom i odnale�� si� w nowej spo�ecznej roli? Analiza zasob�w internetu oraz ryn

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9

Lankenau, Malori A., Ravi Patel, Sandya Liyanarachchi, et al. "MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies." Proceedings of the National Academy of Sciences 112, no. 49 (2015): E6744—E6751. http://dx.doi.org/10.1073/pnas.1520390112.

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The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently mutated gene in malignant melanoma (MM) and papillary thyroid cancer (PTC) and is causally involved in malignant cell transformation. Mutated BRAF is associated with an aggressive disease phenotype, thus making it a top candidate for targeted treatment strategies in MM and PTC. We show that BRAF mutations in both MM and PTC drive increased expression of oncomiR-3151, which is coactivated by the SP1/NF-κB complex. Knockdown of microRNA-3151 (miR-3151) with short hairpin RNAs reduces cell proliferation and increa

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Lima, André Luiz de Araújo, Ana Lúcia Gomes da Silva, and Antenor Rita Gomes. "SO[M]BRAS, PÉROLAS E PORCOS." Revista Espaço do Currículo 16, no. 3 (2023): 1–12. http://dx.doi.org/10.15687/rec.v16i3.68491.

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Este artigo é resultado da pesquisa de mestrado intitulada O fotográfico e a professoralidade: uma cartografia de aproximações e distanciamentos. Nele rastrea-se processos de criação na perspectiva de uma esquizoanálise de memórias, tensionando, entretanto, sem negar frontalmente a ideia de santidade impressa na laicidade da escola, num modo de estetização do espaço escolar e, alhures, produzir linhas de fuga singularizantes a partir do fotográfico, cartografando algumas passagens dessa trilha, embate entre santidade, pérolas e porcos em meio ao lamaçal sombrio e fecundo do processo de vir a s

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11

Mansor, Mohd Rizuan, Mohd Sharizan Md Sarip, Nik Muhammad Azhar Nik Daud, Syahrul Affandi Saidi, Mohd Al Hafiz Mohd Nawi, and Mohd Aminudin Jamlos. "Preparation of Rice Bran Protein (RBP) Powder Using Spray Drying Method at the Optimal Condition and Its Protein Quality." Processes 10, no. 10 (2022): 2026. http://dx.doi.org/10.3390/pr10102026.

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Rice bran is a by-product of the rice milling process. It contains a high concentration of protein. Rice brans are frequently utilized as feed cattle, fertilizer, and fuel. However, their application as human nutrition supplements is uncommon, and the necessary process for this purpose is yet to be established, including the drying process. This study aims to evaluate the effect of the spray-drying parameters, the inlet temperature, inlet flowrate, and inlet air flowrate, on rice bran protein (RBP) powder and optimize it using response surface methodology (RSM). A thermal water-based extractio

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12

Migalska, Aleksandra. "Jak po dwustu latach zrobić miejsce dla prababki, czyli kogo brak w historii myśli socjologicznej recenzja z: Mary Wollstonecraft, Wołanie o prawa kobiety, red. K. Michalczak, Wydawnictwo Ma-mania. Warszawa 2011." Studia Humanistyczne AGH 11, no. 2 (2012): 161. http://dx.doi.org/10.7494/human.2012.11.2.161.

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Jung, Hyojik, Kieun Bae, Ja Young Lee, et al. "Establishment of Canine Transitional Cell Carcinoma Cell Lines Harboring BRAF V595E Mutation as a Therapeutic Target." International Journal of Molecular Sciences 22, no. 17 (2021): 9151. http://dx.doi.org/10.3390/ijms22179151.

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Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract and tends to have a poor prognosis due to its invasive potential. Recent studies have reported that up to 80% of canine urothelial carcinoma has the BRAF V595E mutation, which is homologous to the human V600E mutation. Activating the BRAF mutation is an actionable target for developing effective therapeutic agents inhibiting the BRAF/mitogen-activated protein kinase (MAPK) pathway in canine cancer as well as human cancer. We established novel canine TCC cell lines from two tumor tissues and one met

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14

Bolaji, Josephine Taiye, and Patricia I. Dolez. "Supportive, Fitted, and Comfortable Bras for Individuals with Atypical Breast Shape/Size: Review of the Challenges and Proposed Roadmap." Textiles 2, no. 4 (2022): 560–78. http://dx.doi.org/10.3390/textiles2040032.

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Individuals with atypical breast shape/size often find it quite challenging to obtain a comfortable, supportive, and fitted bra off-the-shelf. They include people with very large breasts, who have significant breast asymmetry, and/or have undergone mastectomy or mammoplasty. This paper provides insights in their challenges and attempts to fill the gap in terms of critical review of the current state of knowledge around the topic of bras. Poor and ill fitted bras are associated with breast, chest and shoulder pain, embarrassment, and an overall reduction in quality of life among others. Buildin

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Pricl, Sabrina, Erik Laurini, Domenico Marson, and Gabriele Cavalieri. "Abstract C153: Rare BRAF mutations in menlanoma and beyond: Rationalizing the afficacy of B-raf inhibitors via HPC-based in silico/in vitro investigations." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): C153. http://dx.doi.org/10.1158/1535-7163.targ-23-c153.

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Abstract Melanoma is a highly aggressive type of cancer that affects the integumentary system and for which a family history of the disease, a fair complexion, the presence of a large number of moles, and skin exposure to natural/artificial ultraviolet (UV) radiation constitute established risk factors for malignancy development. The v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) is a serine/threonine protein kinase that plays a critical role in the RAS-RAF-MEK-ERK mitogen–activated protein kinase (MAPK) cell signaling pathway. Despite over 20 years of research into the regulation and f

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Tamura, Shuta, Hiroshi Tazawa, Naoto Hori, et al. "p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells." PLOS ONE 18, no. 11 (2023): e0294491. http://dx.doi.org/10.1371/journal.pone.0294491.

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Colorectal cancer (CRC) cells harboring KRAS or BRAF mutations show a more-malignant phenotype than cells with wild-type KRAS and BRAF. KRAS/BRAF–wild-type CRCs are sensitive to epidermal growth factor receptor (EGFR)-targeting agents, whereas KRAS/BRAF–mutant CRCs are resistant due to constitutive activation of the EGFR-downstream KRAS/BRAF signaling pathway. Novel therapeutic strategies to treat KRAS/BRAF mutant CRC cells are thus needed. We recently demonstrated that the telomerase-specific replication-competent oncolytic adenoviruses OBP-301 and p53-armed OBP-702 exhibit therapeutic potent

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Hernández, Ernesto Almora, Nabila Figueredo Moreno, Susana Matos Oliveros, Vivian Lago Abascal, and Efraín Rodríguez Jiménez. "Benefits of the Moringa oleifera seed husk as bran for human consumption." International Journal of Complementary & Alternative Medicine 17, no. 1 (2024): 1–5. http://dx.doi.org/10.15406/ijcam.2024.17.00675.

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Bran is the husk of cereals, crushed by grinding. It is a food that helps improving different symptoms, mainly for the digestive system. Moringa oleifera Lam. It is a plant with a high nutritional value, so the use of Moringa seed husk was evaluated for human consumption and for strengthening foods by producing bran. To characterize the Moringa seed husk for human consumption as bran and emphasize its benefits to health. The bran was produced by grinding Moringa oleifera Lam. seed husks with a sieve of 2.0mm. The proximal composition was made by infrared near spectrocospy. The determination of

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De Paepe, Kim, Joran Verspreet, Mohammad Naser Rezaei, et al. "Isolation of wheat bran-colonizing and metabolizing species from the human fecal microbiota." PeerJ 7 (January 25, 2019): e6293. http://dx.doi.org/10.7717/peerj.6293.

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Undigestible, insoluble food particles, such as wheat bran, are important dietary constituents that serve as a fermentation substrate for the human gut microbiota. The first step in wheat bran fermentation involves the poorly studied solubilization of fibers from the complex insoluble wheat bran structure. Attachment of bacteria has been suggested to promote the efficient hydrolysis of insoluble substrates, but the mechanisms and drivers of this microbial attachment and colonization, as well as subsequent fermentation remain to be elucidated. We have previously shown that an individually depen

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Crispo, Fabiana, Tiziana Notarangelo, Michele Pietrafesa, et al. "BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives." Cancers 11, no. 9 (2019): 1388. http://dx.doi.org/10.3390/cancers11091388.

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The Kirsten rat sarcoma viral oncogene homolog (RAS)/v-raf-1 murine leukemia viral oncogene homolog 1 (RAF)/mitogen-activated protein kinase 1 (MAPK) signaling cascade is the most important oncogenic pathway in human cancers. Tumors leading mutations in the gene encoding for v-raf murine sarcoma viral oncogene homolog B (BRAF) serine-threonine kinase are reliant on the MAPK signaling pathway for their growth and survival. Indeed, the constitutive activation of MAPK pathway results in continuous stimulation of cell proliferation, enhancement of the apoptotic threshold and induction of a migrato

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Franovic, Aleksandra, Nichol Miller, Paul Severson, et al. "The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3116. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3116.

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3116 Background: Oncogenic BRAF gene alterations, leading to aberrantly activated BRAF monomers (Class I mutations) or dimers (Class II and Class III mutations), are observed in approximately 6% of all human cancers. First-generation BRAF inhibitors targeting Class I BRAF mutants, including dabrafenib, encorafenib, and vemurafenib, provide significant clinical benefit to patients with BRAF V600 mutation-driven melanoma and select solid tumors as monotherapies or in combination with other targeted therapies. The currently approved BRAF inhibitors have not, however, proven to be effective in pat

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Zarei, Iman, Emily Luna, Jan Leach, et al. "Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene–Bran Metabolite Relationships." Metabolites 8, no. 4 (2018): 63. http://dx.doi.org/10.3390/metabo8040063.

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Rice (Oryza sativa L.) processing yields ~60 million metric tons of bran annually. Rice genes producing bran metabolites of nutritional and human health importance were assessed across 17 diverse cultivars from seven countries using non-targeted metabolomics, and resulted in 378–430 metabolites. Gambiaka cultivar had the highest number and Njavara had the lowest number of metabolites. The 71 rice bran compounds of significant variation by cultivar included 21 amino acids, seven carbohydrates, two metabolites from cofactors and vitamins, 33 lipids, six nucleotides, and two secondary metabolites

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Hersey, Peter, David Wroblewski, Branka Mijatov, Xu Dong Zhang, and Nikolas Haass. "Effect of the BH3 mimetic ABT-737 on human melanoma cells to apoptosis induced by selective BRAF inhibitors." Journal of Clinical Oncology 30, no. 15_suppl (2012): 8553. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.8553.

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8553 Background: Although the introduction of selective BRAF inhibitors has been a major advance in treatment of metastatic melanoma, approximately 50% of patients have limited responses including stabilisation of disease or no response at all. The present study aims to identify a novel means of overcoming resistance of melanoma to killing by BRAF inhibitors. Methods: We examined the influence of the BH3 mimetic ABT-737 on induction of apoptosis by the selective BRAF inhibitor PLX4720 on a panel of melanoma cells with BRAF V600E mutations with or without mutations of CDK4 and BRAF wildtype cel

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Smith, Andrew Paul, Eddie Deaville, and Glenn Gibson. "Wheat Bran Cereal, Human Gut Bacteria and Subjective Wellbeing." Journal of Food Research 7, no. 3 (2018): 8. http://dx.doi.org/10.5539/jfr.v7n3p8.

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Research has shown that consumption of high fiber breakfast cereal is associated with improved subjective well-being, especially increased energy. One possible explanation of these results is through metabolism by gut bacteria and concomitant production of metabolites that influence psychological and gastrointestinal (GI) welfare. This was examined in the present study to determine whether consumption of wheat bran could modulate the composition of the GI microbiota. This human volunteer study (20 volunteers) involved the comparison of three breakfast cereals, All-Bran, Bran Flakes and Cornfla

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Stämpfli, Rolf, Martin Camenzind, Simon Annaheim, Ivona Jerkovic, Rene M. Rossi, and Claudia Glass. "Female manikin for the evaluation of breast support provided by sports bras." Current Issues in Sport Science (CISS) 9, no. 2 (2024): 074. http://dx.doi.org/10.36950/2024.2ciss074.

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Introduction The effect of breast support on running biomechanics (Milligan, 2013) and breast pain on upper-extremity kinematics during running (White et al., 2015) is investigated by different research groups. They mostly found a higher implication for females with large breasts and showed that the use of sports bras is generally beneficial compared to regular bras. A well-fitted supportive sports bra can increase an athlete's performance (Fong & Powell, 2022) and reduce the risk of injuries. The support properties of bras are conventionally evaluated by human trials. This is

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Parker, Kristopher D., Akhilendra K. Maurya, Hend Ibrahim, et al. "Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation." Biomedicines 9, no. 2 (2021): 144. http://dx.doi.org/10.3390/biomedicines9020144.

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Rice bran, removed from whole grain rice for white rice milling, has demonstrated efficacy for the control and suppression of colitis and colon cancer in multiple animal models. Dietary rice bran intake was shown to modify human stool metabolites as a result of modifications to metabolism by gut microbiota. In this study, human stool microbiota from colorectal cancer (CRC) survivors that consumed rice bran daily was examined by fecal microbiota transplantation (FMT) for protection from azoxymethane and dextran sodium sulfate (AOM/DSS) induced colon carcinogenesis in germ-free mice. Mice transf

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Miller, Nichol L. G., Tim S. Wang, Paul Severson, et al. "Abstract 2674: Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in preclinical models of human RAF/RAS mutant melanoma." Cancer Research 82, no. 12_Supplement (2022): 2674. http://dx.doi.org/10.1158/1538-7445.am2022-2674.

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Abstract Background: In the US in 2021, invasive melanoma will account for an estimated 106,000 new cases and &gt; 7,000 deaths. Somatic mutations that activate the MAPK signaling pathway are a leading cause of melanoma with 50% harboring oncogenic BRAF alterations and another 20% with activating NRAS mutations. Of note, NRAS mutant melanoma has been shown to be dependent upon RAF signaling via CRAF dimers for downstream activation of MEK/ERK. While targeted therapies are approved for V600 (Class I, monomer-driven) BRAF mutant melanoma, no approved targeted therapy exists for patients with

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Kuan, Feng-Che, Chung-Sheng Shi, and Meng-Hung Lin. "Correlation of BRAF genomic alterations with higher mutation burden and predictive response to immune checkpoint inhibitors among human malignancies." Journal of Clinical Oncology 40, no. 16_suppl (2022): e14589-e14589. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e14589.

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e14589 Background: The treatment of BRAF-mutated melanoma leads the evolution of management in BRAF-mutated human malignancies from targeted agents to immune checkpoint inhibition. The correlation between BRAF genomic alterations and mutation burden is not well-studied as well as its prognostic role and predictive role to immune checkpoint inhibitors. Methods: Three Public genomic database (AACR GENIE v.11 [N = 119,058], MSKCC pan-cancer [10,080], MSKCC ICI [1,608]) were retrieved from cBioPortal ( https://www.cbioportal.org ). Raw data of cancer types, BRAF status, mutation counts (MC), expos

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Kuan, Feng-Che, Chung-Sheng Shi, and Meng-Hung Lin. "Correlation of BRAF genomic alterations with higher mutation burden and predictive response to immune checkpoint inhibitors among human malignancies." Journal of Clinical Oncology 40, no. 16_suppl (2022): e14589-e14589. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e14589.

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e14589 Background: The treatment of BRAF-mutated melanoma leads the evolution of management in BRAF-mutated human malignancies from targeted agents to immune checkpoint inhibition. The correlation between BRAF genomic alterations and mutation burden is not well-studied as well as its prognostic role and predictive role to immune checkpoint inhibitors. Methods: Three Public genomic database (AACR GENIE v.11 [N = 119,058], MSKCC pan-cancer [10,080], MSKCC ICI [1,608]) were retrieved from cBioPortal ( https://www.cbioportal.org ). Raw data of cancer types, BRAF status, mutation counts (MC), expos

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Trianto, Agus, Sri Sedjati, Ocky Karna Radjasa, et al. "Pemanfaatan Jamur Simbion Sponge dalam Bioisomerasi Asam Lemak pada Dedak untuk Menghasilkan Asam Lemak Cis." Jurnal Kelautan Tropis 21, no. 2 (2018): 121. http://dx.doi.org/10.14710/jkt.v21i2.3559.

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Utilization of Sponges Symbiotic Fungus in the Bioisomeration of Fatty Acids in Brans to Produce Cis Fatty Acid Trans fatty acids are known to have a negative impact on human health such as triggering the coronary heart and blood vessel related diseases. However, many food and animal feed contain trans fatty acids. Bran, which is widely used as animal feed has high fatty acid content and the majority are trans fatty acids. This study aims to determine the potential of Trichoderma harzanum, a sponge symbiont fungus, in the process of fatty acid bioconversion in bran. Bran was fermented in salin

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Marais, R. "BRAF and RAS signalling in human melanoma." European Journal of Cancer Supplements 6, no. 9 (2008): 120. http://dx.doi.org/10.1016/s1359-6349(08)71632-x.

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Wang, Hui, Wenrui Zhang, Rujiao Liu, et al. "Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice." Life Science Alliance 5, no. 11 (2022): e202201368. http://dx.doi.org/10.26508/lsa.202201368.

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Bombesin receptor–activated protein (BRAP) was found to express in the interstitial cells of human fibrotic lungs with unknown function. Its homologous protein, encoded by BC004004 gene, was also present in mouse lung tissues. We used BC004004−/− mice which lack BRAP homologous protein expression to establish a bleomycin-induced lung fibrotic model. After bleomycin treatment, BC004004−/− mice exhibited attenuation of pulmonary injury and less pulmonary fibrosis. Fibroblasts from BC004004−/− mice proliferated at a lower rate and produced less collagen. Autophagy-related gene 5 (ATG5) was identi

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Cesta Incani, Ursula, Anais Del Curatolo, Cristina Di Sanza, et al. "Synergistic activity of vertical combinations of agents targeting multiple steps along the RAF/MEK/ERK cascade as a therapeutic strategy in human tumors." Journal of Clinical Oncology 30, no. 15_suppl (2012): e13572-e13572. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13572.

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e13572 Background: BRAF-selective kinase inhibitors have potent antitumor effects in mutant BRAF(V600E) tumors; however, in BRAF-wt cells, they paradoxically activate MEK/ERK. In addition, MEK blockade may induce compensatory signaling through both upstream pathway elements (RAF) and parallel pathways (PI3K/AKT/mTOR). Methods: We set out to define molecular and functional effects of single and combined BRAF (GSK2118436A, BRAF-I) and MEK (GSK1120212B, MEK-I) inhibition, using WB analysis to dissect signaling and a fixed dose-ratio experimental design to assess functional synergism by conservati

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Santoso, V., T. Estiasih, and W. D. R. Putri. "Utilization of rice bran for wheat flour substitution in noodle product development: a review." IOP Conference Series: Earth and Environmental Science 924, no. 1 (2021): 012023. http://dx.doi.org/10.1088/1755-1315/924/1/012023.

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Abstract Rice bran is a by-product of polishing in the rice milling process. Rice bran contains numerous bioactive compounds with a beneficial effect on human health, namely dietary fiber, flavonoid, tocopherol, tocotrienol, and gamma-oryzanol. Since the trend of healthy food has been rising, rice bran has been taken an interest to use in functional food development. Noodle products are often developed as a functional food due to widely consumed foods and as a great carrier to deliver bioactive compounds. The utilization of rice bran could change noodle quality attributes which influences mark

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Stewart, Maria L., and Joanne L. Slavin. "Particle size and fraction of wheat bran influence short-chain fatty acid productionin vitro." British Journal of Nutrition 102, no. 10 (2009): 1404–7. http://dx.doi.org/10.1017/s0007114509990663.

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Whole grains are associated with decreased risk of chronic disease and decreased risk of obesity. Several mechanisms may be involved including SCFA production via fibre fermentation in the colon. The aim of the present study was to evaluate the role of wheat bran particle size (large/coarsev.small/fine) and wheat bran fraction (whole branv.aleuronev.aleurone by-product) in SCFA production using a batchin vitrofermentation system with human faecal inoculum. Five samples were compared: large-particle bran, small-particle bran, aleurone, coarse by-product, fine by-product. Fine by-product produce

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Schreck, Karisa, Andrew Morin, Guisheng Zhao, et al. "DDRE-13. DECONVOLUTING MECHANISMS OF RESISTANCE TO BRAF INHIBITORS IN BRAF V600E HUMAN GLIOMA." Neuro-Oncology 22, Supplement_2 (2020): ii64. http://dx.doi.org/10.1093/neuonc/noaa215.258.

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Abstract BACKGROUND While BRAF-targeted therapy can be effective in a subset of patients with glioma, resistance to treatment can emerge over time. The description and validation of mechanisms of resistance in BRAF-mutant glioma are not previously described. METHODS Pre- and post- BRAF inhibitor (BRAFi) or BRAFi/MEK inhibitor (MEKi) treated patient samples were obtained under IRB-approved protocols at University of Colorado Denver, UCSF, and Johns Hopkins. Targeted DNA sequencing or whole exome sequencing (WES), and RNA-seq were conducted on paired samples. Functional validation of putative re

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Jansen, Philipp, Ioana Cosgarea, Rajmohan Murali, et al. "Frequent Occurrence of NRAS and BRAF Mutations in Human Acral Naevi." Cancers 11, no. 4 (2019): 546. http://dx.doi.org/10.3390/cancers11040546.

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Acral naevi are benign melanocytic tumors occurring at acral sites. Occasionally they can progress to become malignant tumors (melanomas). The genetics of acral naevi have not been assessed in larger studies. In our study, a large cohort of 130 acral naevi was screened for gene mutations known to be important in other naevi and melanoma subtypes by targeted next-generation sequencing. Mutation status was correlated with clinicopathological parameters. Frequent mutations in genes activating the MAP kinase pathway were identified, including n = 87 (67%) BRAF, n = 24 (18%) NRAS, and one (1%) MAP2

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McCallum, Margaret E., and Deborah L. Rhode. ""Now That We've Burned Our Bras...": Review of "Justice and Gender"." Labour / Le Travail 27 (1991): 257. http://dx.doi.org/10.2307/25130254.

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Zhang, Zongjing, Dingxie Liu, Avaniyapuram Kannan Murugan, Zhimin Liu, and Mingzhao Xing. "Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer." Endocrine-Related Cancer 21, no. 2 (2013): 161–73. http://dx.doi.org/10.1530/erc-13-0399.

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The BRAF V600E mutation causes impaired expression of sodium iodide symporter (NIS) and radioiodine refractoriness of thyroid cancer, but the underlying mechanism remains undefined. In this study, we hypothesized that histone deacetylation at the NIS (SLC5A5) promoter was the mechanism. Using the chromatin immunoprecipitation approach, we examined histone acetylation status on the lysine residues H3K9/14, H3K18, total H4, and H4K16 at the NIS promoter under the influence of BRAF V600E. We found that expression of stably or transiently transfected BRAF V600E inhibited NIS expression while the d

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Yu, Shihui, and William D. Graf. "BRAF Gene Deletion Broadens the Clinical Spectrum Neuro-Cardio-Facial-Cutaneous Syndromes." Journal of Child Neurology 26, no. 12 (2011): 1593–96. http://dx.doi.org/10.1177/0883073811413830.

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Point mutations in the human BRAF gene are associated with a group of heterogeneous autosomal dominant neuro-cardio-facial-cutaneous syndromes. We identified a novel 93 kb intragenic deletion of the BRAF gene in a boy with severe developmental encephalopathy using microarray-based comparative genomic hybridization. The unique genotype and phenotype in this patient expands the spectrum of BRAF-related neurodevelopmental disorders. We propose a BRAF gene loss-of-function mechanism to best explain the biological basis of this severe developmental encephalopathy with postnatal growth deficiency.

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Sheldon, William. "Rafting the Martha Brae." Organization & Environment 11, no. 4 (1998): 478. http://dx.doi.org/10.1177/0921810698114018.

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Karreth, Florian, Markus Reschke, Bjoern Chapuy, Margaret A. Shipp, Roberto Chiarle, and Pier Paolo Pandolfi. "The BRAF Pseudogene Is a Proto-Oncogenic Competitive Endogenous RNA." Blood 124, no. 21 (2014): 263. http://dx.doi.org/10.1182/blood.v124.21.263.263.

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Abstract Non-coding RNAs have long been viewed as non-functional genomic relicts of evolution, but recetn findings have implicated their importance in physiology and disease. Recently, in vitro experiments demonstrated that the pseudogenes of PTEN and KRAS operate as natural miRNA decoys (competitive endogenous RNAs or ceRNAs) that regulate the expression of their parental genes. However, in vivo evidence for a causal role of pseudogenes in cancer development is lacking. To investigate whether the BRAF pseudogene (BRAFps) possesses oncogenic properties we generated transgenic mice carrying a T

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Vera, Olga, Ilah Bok, Neel Jasani, Oluwashanu Balogun, Koji Nakamura, and Florian Karreth. "Abstract PR12: Regulation of the tumor-suppressive miR-29 family by oncogenic MAPK signaling in melanoma." Cancer Research 80, no. 19_Supplement (2020): PR12. http://dx.doi.org/10.1158/1538-7445.mel2019-pr12.

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Abstract MicroRNAs are a group of noncoding RNAs that can regulate gene expression by targeting the mRNA of a gene. Many microRNAs respond to different stimuli such as growth signals or cellular stress. The tumor-suppressive miR-29 family (miR-29a, b and c), for example, is induced during aging and senescence as a p53-dependent response to DNA damage. Given the tumor-suppressive potential of miR-29, we sought to examine if its expression is induced by oncogenic stress in a p53-dependent manner. Ectopic overexpression of oncogenic Braf-V600E and Kras-G12D in mouse embryonic fibroblasts (MEFs) u

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Li, Yinghui, Hui Shan Cheng, Wee Joo Chng, and Vinay Tergaonkar. "Activation of mutantTERTpromoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas." Proceedings of the National Academy of Sciences 113, no. 50 (2016): 14402–7. http://dx.doi.org/10.1073/pnas.1611106113.

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Although activating BRAF/NRAS mutations are frequently seen in melanomas, they are not sufficient to drive malignant transformation and require additional events. Frequent co-occurrence of mutations in the promoter fortelomerase reverse transcriptase(TERT), along with BRAF alterations, has recently been noted and correlated with poorer prognosis, implicating a functional link between BRAF signaling and telomerase reactivation in melanomas. Here, we report that RAS-ERK signaling in BRAF mutant melanomas is critical for regulating active chromatin state and recruitment of RNA polymerase II at mu

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Chen, Feifan, Priyadharsini Nagarajan, and Phyu P. Aung. "Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases." Dermatopathology 11, no. 3 (2024): 177–83. http://dx.doi.org/10.3390/dermatopathology11030018.

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Digital papillary adenocarcinoma (DPA) is a rare malignant neoplasm which arises from the sweat glands and has metastatic potential. DPA exhibits a wide range of architectural features and exhibits low-grade to high-grade features, so distinguishing DPA from benign skin neoplasms, including acral hidradenoma, poses significant diagnostic challenges. The recent literature suggests a strong association between DPA and human papillomavirus (HPV) 42, a low-risk HPV (LR-HPV) subtype, and a possible association between DPA and BRAF p.V600E. To explore these associations, we assessed the utility of i

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45

Smythe, J., B. Gardner, and DJ Anstee. "Quantitation of the number of molecules of glycophorins C and D on normal red blood cells using radioiodinated Fab fragments of monoclonal antibodies." Blood 83, no. 6 (1994): 1668–72. http://dx.doi.org/10.1182/blood.v83.6.1668.1668.

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Abstract Two rat monoclonal antibodies (BRAC 1 and BRAC 11) have been produced. BRAC 1 recognizes an epitope common to the human erythrocyte membrane glycoproteins glycophorin C (GPC) and glycophorin D (GPD). BRAC 11 is specific for GPC. Fab fragments of these antibodies and BRIC 10, a murine monoclonal anti-GPC, were radioiodinated and used in quantitative binding assays to measure the number of GPC and GPD molecules on normal erythrocytes. Fab fragments of BRAC 11 and BRIC 10 gave values of 143,000 molecules GPC per red blood cell (RBC). Fab fragments of BRAC 1 gave 225,000 molecules of GPC

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Smythe, J., B. Gardner, and DJ Anstee. "Quantitation of the number of molecules of glycophorins C and D on normal red blood cells using radioiodinated Fab fragments of monoclonal antibodies." Blood 83, no. 6 (1994): 1668–72. http://dx.doi.org/10.1182/blood.v83.6.1668.bloodjournal8361668.

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Two rat monoclonal antibodies (BRAC 1 and BRAC 11) have been produced. BRAC 1 recognizes an epitope common to the human erythrocyte membrane glycoproteins glycophorin C (GPC) and glycophorin D (GPD). BRAC 11 is specific for GPC. Fab fragments of these antibodies and BRIC 10, a murine monoclonal anti-GPC, were radioiodinated and used in quantitative binding assays to measure the number of GPC and GPD molecules on normal erythrocytes. Fab fragments of BRAC 11 and BRIC 10 gave values of 143,000 molecules GPC per red blood cell (RBC). Fab fragments of BRAC 1 gave 225,000 molecules of GPC and GPD p

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Ross, Yasmeen B., Mahbubul Hoque, Jesse D. Blanton, et al. "Rabies healthcare-seeking behaviors of urban and peri-urban residents: Results from a rabies knowledge, attitudes, and practices survey, Bangladesh, 2018." PLOS Neglected Tropical Diseases 16, no. 8 (2022): e0010634. http://dx.doi.org/10.1371/journal.pntd.0010634.

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Rabies is one of the most lethal infectious diseases, with those living in Asia and Africa having the highest risk of dying from rabies. We conducted a knowledge, attitudes and practices survey in urban and peri-urban areas of Bangladesh to describe canine bite rates, rabies knowledge, and healthcare seeking behaviors and barriers to human and dog vaccination. A bite risk assessment score (BRAS) and healthcare-seeking behavior score (HSBS) was calculated for each bite victim. Respondents were given two hypothetical situations to assess potential behaviors after a bite and willingness to pay fo

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Wakuda, Yuki, Akiko Noda, Yasuhisa Hasegawa, Fumihito Arai, Toshio Fukuda, and Mitsuo Kawaguchi. "Biological Rhythm Based Wearable Sleep State Observer." Journal of Advanced Computational Intelligence and Intelligent Informatics 11, no. 2 (2007): 232–41. http://dx.doi.org/10.20965/jaciii.2007.p0232.

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This research aimed to observe human biological rhythm and adjust the human sleep wake pattern based on controlling wakeup timing using low stress system. An ordinary alarm clock operates according to preset time. Biological rhythm determines the human sleep cycle, which affects sleep depth and wakeup timing, which in turn resets the daily rhythm that affects human’s behavior, life-cycle pattern, life-style related disease. We developed a wearable biological rhythm based awakening controller (BRAC) that determines the biological rhythm in the sleep state (sleep cycle) and stimulates the user a

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Wang, Tim S., Catherine Lee, Paul Severson, Robert J. Pelham, Richard Williams, and Nichol L. G. Miller. "Abstract 4927: Exarafenib (KIN-2787) is a potent, selective pan-RAF inhibitor with activity in preclinical models of BRAF class II/III mutant and NRAS mutant melanoma." Cancer Research 83, no. 7_Supplement (2023): 4927. http://dx.doi.org/10.1158/1538-7445.am2023-4927.

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Abstract Background: MAPK activating mutations are common in melanoma, with 40% of cases attributed to oncogenic BRAF mutations and 20-25% NRAS mutations. Secondary MAPK activation is a known resistance mechanism to approved BRAF inhibitors in BRAFV600 melanoma. While BRAF inhibitors are approved for Class I BRAFV600 melanomas, patients with dimer-driven BRAF Class II/III and RAF1-dependent NRAS activated melanomas lack approved targeted therapy. Development of next-gen pan-RAF inhibitors targeting all RAF proteins and mutant dimers remains a priority. Emerging clinical data from pan-RAF inhib

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Dolinsek, Tanja, Lara Prosen, Maja Cemazar, Tjasa Potocnik, and Gregor Sersa. "Electrochemotherapy with bleomycin is effective in BRAF mutated melanoma cells and interacts with BRAF inhibitors." Radiology and Oncology 50, no. 3 (2016): 274–79. http://dx.doi.org/10.1515/raon-2016-0042.

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Abstract Background The aim of the study was to explore the effectiveness of electrochemotherapy (ECT) during the treatment of melanoma patients with BRAF inhibitors. Its effectiveness was tested on BRAF mutated and non-mutated melanoma cells in vitro and in combination with BRAF inhibitors. Materials and methods ECT with bleomycin was performed on two human melanoma cell lines, with (SK-MEL-28) or without (CHL-1) BRAF V600E mutation. Cell survival was determined using clonogenic assay to determine the effectiveness of ECT in melanoma cells of different mutation status. Furthermore, the effect

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