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Rozprawy doktorskie na temat „Calcium Activated Potassium (BK) Channels”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Macdonald, Stephen Hsiao-Feng. "Alternative splicing of large-conductance calcium- and voltage-activated potassium (BK) channels." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29237.

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The aim of this thesis was to test the hypotheses that: i) alternative splicing may control subcellular localisation of BK channel α-subunits and ii) splice variants are differentially expressed in tissues, using the murine BK channel as the model system. To address whether alternative splice variants may be trafficked specifically to different subcellular compartments, epitope-tagged BK channel splice variants were expressed in a mammalian epithelial and endocrine cells. STREX and ZERO variants, in contrast to splice variant Δe23 that is C-terminally truncated, efficiently trafficked to the p

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2

Krishnamoorthy, Gayathri. "MECHANISM OF CALCIUM DEPENDENT GATING OF BKCa CHANNELS: RELATING PROTEIN STRUCTURE TO FUNCTION." online version, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1144444855.

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Apolinar, Sanrda. "BK channel involvement in beta-adrenergic relaxation of murine tracheal smooth muscle a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=32&CISOBOX=1&REC=3.

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Coghill, Lorraine Sheila. "Regulation of large conductance calcium- and voltage-activated potassium (BK) channel splice variants by protein kinase A." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23309.

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Wynne, Patricia M. "Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/399.

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BK channels are well studied targets of acute ethanol action. They play a prominent role in neuronal excitability and have been shown to play a significant role in behavioral ethanol tolerance in invertebrates. The focus of my work centers on the effects of alcohol on the BK channel and comprises studies that examine how subcellular location affects acute ethanol sensitivity and how duration of acute alcohol exposure impacts the development of rapid tolerance. My results also provide potential mechanisms which underlie acute sensitivity and rapid tolerance. I first explore BK channel sensitivi

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Feinberg-Zadek, Paula Leslie. "Alcohol Modulation of Human BK Channels Evidence for β-Subunit Dependent Plasticity in Functional Ethanol Tolerance: A Dissertation". eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/195.

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Alcoholism is responsible for more than 6% of deaths internationally per annum. The development of acute tolerance to ethanol (EtOH) is a critical component of alcoholism. Previous studies identified large conductance calcium-activated potassium (BK) channels as potential EtOH targets in a variety of species and cells. In order to elucidate mechanisms underlying tolerance development, I used inside-out patch clamp techniques to measure EtOH induced changes in channel activity (measured as open probability) of hSlo, hSlo+β1, and hSlo+β4 channels exogenously expressed in HEK 293 cells. I show th

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7

Georgiou, Panayiotis Paulou. "Calcium-activated potassium-channels in mammalian eggs." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/29774.

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8

Millership, Joanne Ella. "Regulation and function of calcium-activated potassium channels." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503016.

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9

Bi, Danlei. "Palmitoylation of large conductance voltage- and calcium-dependent potassium (BK) channels." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17286.

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S-palmitoylation is a reversible post-translational lipid modification of proteins by adding a 16-carbon palmitate onto a cysteine residue. Palmitoylation has been shown to control the trafficking and function of many signalling proteins including ion channels. In this Thesis, palmitoylation is shown to control both the plasma membrane expression and gating properties of large conductance calcium- and voltage- dependent potassium (BK) channels. The BK channel is assembled from four pore-forming α-subunits. Each α-subunit contains seven transmembrane domains (S0-S6), with an extracellular N-ter

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10

D'hoedt, Dieter. "Structure-function analyses of small-conductance, calcium-activated potassium channels." Diss., [S.l.] : [s.n.], 2005. http://edoc.ub.uni-muenchen.de/archive/00006036.

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11

Lippiat, Jonathan David. "Molecular properties of recombinant large conductance calcium-activated potassium channels." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29928.

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1. Currents through large conductance calcium-activated potassium channels were recorded using path clamp from human embryonic kidney (HEK) cells expressing recombinant DNA. 2. The permeation of potassium ions through single cloned rat channels, rSlo+1m was described using Eyring's rate theory. The model included two energy wells and three barriers. N-methyl-D-glucamine was found to block potassium permeation by binding to the intracellular binding site in the pore. 3. A HEK cell line was generated that stably expressed the human bladder BKCa channel subunit (hSlo). Macroscopic currents record

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12

Hagen, Brian M. "Regulation of calcium-activated potassium channels by localized calcium transients in murine colon." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209955.

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13

Bohm, Rudy Ashish. "Transcriptional control of slowpoke, a calcium activated potassium channel gene /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004218.

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14

Deng, Zhihui. "SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS IN MAMMALIAN SPINAL MOTONEURONS." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1237821684.

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Clarke, Alison L. "Mechanism of Fatty Acid Modulation of Calcium-Activated Potassium Channel Activity." eScholarship@UMMS, 1997. http://escholarship.umassmed.edu/gsbs_diss/277.

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The purpose of this work was to determine whether the previously identified fatty acid activation of large conductance Ca2+-activated K+ (BK) channels from rabbit pulmonary artery smooth muscle cells was due to the direct interaction of the fatty acid with a site on the channel protein. If this was found to be the case, this study would also attempt to identify the site of fatty acid-protein interaction. Fatty acids released from membrane phospholipids by cellular phospholipases or available to the cell from the extracellular environment are important signaling molecules. Fatty acids can modul

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16

Doorty, Kevina Bridget. "Identification of novel toxin inhibitors of apamin-sensitive calcium-activated potassium channels." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286597.

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17

McCartney, Claire Elizabeth. "Effect of hypoxia on neuronal large conductance calcium-activated potassium (BKca) channels." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410156.

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18

Natarajan, Aruna Ramachandran. "Mechanism of dopamine-mediated activation of BK channels in human coronary artery smooth muscle cells." Connect to Electronic Thesis (ProQuest) Connect to Electronic Thesis (CONTENTdm), 2008. http://worldcat.org/oclc/457179694/viewonline.

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Inglis, Victoria. "The effect of ã-dendrotoxin on calcium-activated potassium channels in neuroblastoma cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0008/MQ60131.pdf.

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Petrik, David. "The role of the ß4 subunit in phosphorylation of calcium-activated potassum [sic] channels a dissertation /." San Antonio : UTHSC, 2008. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1588771871&sid=3&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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21

Joshi, Atul. "A possible link between calmodulin and calcium-activated potassium channels in bovine chromaffin cells /." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55663.

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22

Bahia, Parmvir Kaur. "A study of small and intermediate conductance calcium-activated potassium channels in sensory neurones." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445301/.

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The role of small and intermediate conductance calcium-activated potassium channels (SK and IK channels) in dorsal root ganglion (DRG) neurones was examined. Sixteen antibodies raised against human or rat SK/IK channel peptide epitopes were tested for their ability to stain cells expressing channel protein. Of sixteen antibodies, 12 (6 to SKI, 1 to SK2, 2 to SK3 and 3 to IK) were deemed suitable for immunohistochemistry in human or rat tissue. Real-time quantitative PCR (qPCR) of rat DRG cDNA was performed to examine SK/IK expression levels. DRG neurones produce mRNA for all SK/IK channels and

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23

Chu, Benson. "Alcohol Modulation of N-methyl-D-aspartate Gated Receptor/Channels and Large Conductance Calcium-Activated Potassium Channels: a Dissertation." eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/164.

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Clinically relevant concentrations of ethanol modulate the function of a number of ion channel proteins. A fundamental question regarding the effects of alcohol is whether the drug modifies ion channels by directly binding to the protein, indirectly by perturbing the surrounding membrane lipid, or some combination of both. This thesis further characterized ethanol's site of action by examining the effects of ethanol on N-methyl-D-aspartate (NMDA) receptor/channels and large conductance Ca2+-activated K+ (BK) channels at a number of levels using direct electrophysiological methods. In Chapter O

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24

Sane, Mukta. "Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries." Diss., North Dakota State University, 2016. http://hdl.handle.net/10365/25665.

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25

Saqar, Wedad Ali. "Characterization of Small Conductance Calcium-Activated Potassium Channels in a Human Lens Epithelium Cell Line (B3)." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1401279427.

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26

Murphy, Matthew M. "Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428.

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Tjong, Yung-wui. "Mechanisms of attenuated large conductance calcium-activated potassium channel activity in rat hippocampal CA1 pyramidal neurons in chronic intermittent hypoxia." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793953.

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28

Kye, Min-Jeong. "Regulation of small-conductance, calcium-activated potassium channels (SK) in mouse brain in response to aging and stress." [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/kye/kye.pdf.

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Ro, Seungil. "SK channels : distribution, function and regulation in mouse colonic myocytes /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090879.

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30

Hillman, David James. "Membrane currents evoked by vasoactive compounds in vascular endothelial cells : contributions of small and intermediate conductance calcium-activated potassium channels." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445578/.

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The contribution of different calcium-activated potassium channel subtypes to agonist-evoked whole-cell currents was studied in cultured pig coronary artery endothelial cells. From a resting membrane potential of-5.9 0.5mV (n=102), 1-lOuM ATP, 1-1 OnM substance P and 1-lOOnM bradykinin hyperpolarised cell rafts to -50.7 1.6mV (n=76), -45.7 4.7mV (n=19) and -59.1 3.5mV (n=16), respectively. In small clusters of cells, 1 OuM ATP evoked outward currents which reversed close to EK and were sensitive to both the SKca channel blocker UCL 1848 (IC5o 1.2nM -65% maximal block) and the IKca/BKca channel

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Shah, Yousef. "Effects of point mutations on the block of SK3 small-conductance calcium-activated potassium channels expressed in mammalian cell lines." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446491/.

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Small conductance calcium-activated K+ channels (SK channels) form a subfamily of K+ -selective, volt age-insensitive channels that have been recently cloned. This thesis is concerned primarily with an investigation of the pharmacology of these channels. Understanding their pharmacology is of potential clinical importance since SK channels participate in diverse physiological roles, for example, generating neuronal afterhyperpolarizations (that set tonic firing frequencies) and regulating smooth muscle contraction. This thesis consists of two parts. The first is concerned with expressing and e

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32

Holland, Michael. "A patch clamp study of pharmacological and physiological regulators of large conductance calcium-activated potassium channels in arterial smooth muscle cells." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29937.

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In the 1980s a group of vasodilator drugs were found to possess a common mechanism which involved opening KATP channels located in the cell membrane of smooth muscle cells, leading to vasorelaxation via membrane hyperpolarisation. A number of additional K+ channels have been identified in vascular smooth muscle cells and one of these channels, the large conductance calcium-activated K+ channel (BKCa), is a promising therapeutic target.;This thesis uses the various configurations of the patch-clamp technique to examine the effects of NS1619, nitric oxide (NO) and compounds resulting from the ac

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33

Braxton, Joi Requan. "Effect of preload on the response of mouse trachea smooth muscle to cholinergic stimulation a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=33&CISOBOX=1&REC=10.

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Tharp, Darla L. "Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5936.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2007" Includes bibliographical references.

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Assadian, Sarah. "Rodent FDG-PET imaging for the pre-clinical assessment of novel glioma therapies." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101836.

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The rapid discovery of novel therapeutic agents, targeting the specific mechanism of cancer progression, invasion and angiogenesis, necessitates the development and validation of efficient techniques to assess the therapeutic efficacy of these drugs in vivo. Recently the development of dedicated PET scanners for the imaging of small animals, such as the microPET system (CTI Concorde R4), has allowed for the high-resolution functional and molecular imaging of murine and rodent models of disease. This study, investigates the ability of microPET imaging, using the 18F labelled 2-fluoro-2-deoxyglu

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36

D'hoedt, Dieter [Verfasser]. "Structure-function analyses of small-conductance, calcium-activated potassium channels / Dieter D'hoedt." 2005. http://d-nb.info/982304323/34.

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Gao, Yadong [Verfasser]. "The role of calcium-activated potassium channels and store-operated calcium channels in human macrophages / vorgelegt von Yadong Gao." 2007. http://d-nb.info/986359440/34.

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"Functional expression of sperm Ca²⁽-activated K⁽ channels in xenopus oocytes and their modulations by Ca²⁽-evoking agonists." 2000. http://library.cuhk.edu.hk/record=b6073247.

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by So Siu Cheung, Eddie.<br>"September 2000."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2000.<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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Wang, Ya-Jean, and 王雅貞. "Stimulatory Effects of the Estrogen-Receptor Modulators on Large-Conductance Calcium-Activated Potassium Channels." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/13761727049091187819.

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博士<br>國立成功大學<br>基礎醫學研究所<br>96<br>The large conductance Ca2+-activated K+ (BKCa) channels, which are formed by ��-subunit tetramers, are encoded by a nearly ubiquitous, alternatively spliced gene, SLO (KCNMA1). Activation of the channel is under dual control, i.e., allosterically switched on either by membrane depolarization or by increased [Ca2+]i. Recent studies demonstrated that in addition to their binding to estrogen receptors, the modulators of estrogen receptors (ERs) may have direct effects on the activity of these channels in a non-genomic pathway. In these studies, a series of comp

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Licata, Luana [Verfasser]. "High level production, characterization and structural analysis of neuronal calcium-activated potassium channels / von Luana Licata." 2005. http://d-nb.info/977281477/34.

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Yu-KaiLiao and 廖俞凱. "Ibandronate Sodium, a Nitrogen-Containing Bisphosphonate, Inhibits Intermediate-Conductance Calcium-Activated Potassium Channels in RAW264.7 Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/79937041422873694153.

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碩士<br>國立成功大學<br>生理學研究所<br>103<br>Osteoporosis is a bone disease in which the bone becomes fragile and increases fracture risk. Bone remodeling plays an important role in bone homeostasis and is regulated by activity of osteoblasts and osteoclasts. Hyperactivity of osteoclasts may cause osteoporosis because the rate of bone resorption exceeds bone formation. Bisphosphonate drug Ibandronate (Iban, Boniva®) has shown to reduce skeletal complications through inhibiting osteoclast-mediated bone resorption. The intermediate-conductance Ca2+-activated K+ (IKCa) channels (also known as KCa3.1, SK4, IK

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42

Bock, Hans Christoph Tobias. "The impact of calcium-activated potassium channels on dendritic excitability in cortical layer 5 pyramidal neurons." Phd thesis, 2014. http://hdl.handle.net/1885/150473.

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Layer 5 pyramidal neurons are considered that main output units of the cortex. They receive input from all cortical layers onto their large dendritic tree. Dendritic spikes play a key role in the integration of synaptic inputs in these neurons, as they can modulate the gain of distal synaptic inputs and add another computational layer to the cell. These events are associated with calcium influx and therefore may be modulated by calcium-dependent processes such as calcium-activated potassium K(Ca) channels. In this study we investigate the impact of K(Ca) channels on dendritic excitability. We

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43

Yan, Hong. "Action of halothane on large-conductance, calcium-activated potassium channels in rat cerebrovascular smooth muscle cells." Thesis, 1993. http://hdl.handle.net/2429/1567.

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Halothane anesthesia is associated with increased cerebral blood flow and dilatation of cerebral vessels. The mechanisms which underlie this drug action are presently unclear. Cerebrovascular tone is probably regulated in part by the opening of large conductance, Ca²⁺-activated potassium channels (BK channels) in cerebral artery smooth muscle cells. The present experiments utilized extra cellular patch clamp techniques to investigate whether clinically relevant concentrations of halothane directly alter the biophysical properties of these channels. Cerebrovascular smooth muscle cells (CVSMCs)

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44

Tong, Clement Tsz-Ming. "Comparison of drug blockade of a neuronal calcium-activated potassium channel with cardiac repolarizing potassium channels by potential class III agents." Thesis, 1994. http://hdl.handle.net/2429/5546.

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The aim of the study was to examine the use of a repolarizing calcium dependent potassium current K(Ca) in neurons to describe the actions of a group of novel compounds with potential Class ifi actions on cardiac cells. This was accomplished by determination of the correlation between potency of the agents to block single channel K(Ca) and potency to prolong effective refractory period (ERP) in heart. If a positive correlation could be established then elucidation of mechanisms of drug actions on single channel K(Ca) could have utility in the description of drug actions on repolarizing

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45

Zhang, Xian. "Effects of intracellular magnesium on large conductance, calcium-activated potassium channels in rat cerebrovascular smooth muscle cells." Thesis, 1994. http://hdl.handle.net/2429/5108.

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Increasing the plasma concentration of Mg²⁺ above normal levels results in the dilation of cerebral arteries. Conversely, an abnormally low level of Mg²⁺ in plasma has been shown to increase cerebrovascular tone and to induce calcium-mediated vasospastic responses in cerebral vessels. It is known that large conductance, calcium-activated potassium channels (BK channels) play an important role in the regulation of myogenic tone in cerebrovascular smooth muscle cells (CVSMCs). In the vascular smooth muscle cells of systemic vessels, the properties of BK channels are themselves modulated by

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46

Hui-ZhenChen and 陳慧真. "Effects of Ibandronate Sodium, a Bisphosphonate, on the Activity of Calcium-Activated Potassium Channels in Madin-Darby Canine Kidney Cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/e4nam5.

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碩士<br>國立成功大學<br>生理學研究所<br>104<br>Ibandronate sodium (Iban) is a highly potent nitrogen-containing bisphosphonate and effective for the treatment of osteoporosis. It was previously reported to influence the function of renal tubular cells. According to previous studies, Iban is not metabolized in either human or animal and it can then accumulate in the kidney; consequently, it produces hypertrophy and hyperplasia of distal tubules and collecting ducts in the rats. However, whether this drug has any effects on membrane ion channels in kidney cells remains largely unclear. This study was conducte

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"TRPV4-TRPC1- BKca tri-complex mediates epoxyeicosatrienoic acid-induced membrane hyperpolarization." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075501.

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Ma, Yan.<br>"Ca" in the title is subscript.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 143-166).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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"High conductance, Ca2+-activated K+ channel modulation by acetylcholine in single pulmonary arterial smooth muscle cells of the Wistar-Kyoto and spontaneously hypertensive rats." 2007. http://library.cuhk.edu.hk/record=b5893134.

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Kattaya-Annappa-Seema.<br>Thesis submitted in: December 2006.<br>"2+" and "+" in the title are superscripts.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 162-188).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Acknowledgements --- p.viii<br>Abstracts published based on work in this thesis --- p.ix<br>Table of contents --- p.x<br>Chapter Chapter 1: --- Introduction<br>Chapter 1.1 --- Pulmonary hypertension<br>Chapter 1.1.1 --- Pulmonary circulation and its functions --- p.1<br>Chapter 1.1.2 --- Pulmonary vascular d

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"Effect of hyperkalemia and ischemia on large conductance calcium-activated potassium channels in porcine coronary arterial smooth muscle: relevance to cardioplegic arrest." 2008. http://library.cuhk.edu.hk/record=b5893576.

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Han, Jianguo.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.<br>Includes bibliographical references (leaves 66-76).<br>Abstracts in English and Chinese.<br>Declaration --- p.i<br>Acknowledgement --- p.□<br>Publication --- p.□<br>Abstract (English) --- p.□xi<br>Abstract (Chinese) --- p.□<br>Abbreviations --- p.ix<br>List of figures / tables --- p.x<br>Chapter Chapter 1. --- General Introduction<br>Chapter 1.1 --- Role of vascular smooth muscle cells in the control of coronary circulation --- p.1<br>Chapter 1.1.1 --- Potassium channels in the coronary smooth muscle cells ---

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"Modulation of porcine coronary artery BKCa and IKATP channels gatings by 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074588.

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3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG CoA) reductase is a 97 kDa glycoprotein located in the endoplasmic reticulum responsible for cholesterol biosynthesis in mammalian liver and intestine. HMG CoA reductase inhibitors (statins) (e.g. simvastatin, mevastatin and parvastatin) are used clinically to treat and prevent coronary artery diseases by reducing plasma LDL-cholesterol level. Recent studies have demonstrated that statins can provide beneficial effects (pleiotropic effects) beyond its lipid-lowering activity. However, the modulatory effects of statins on ion channels activities have n

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