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Rozprawy doktorskie na temat „Calpain”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Czerwinski, Eric Paul. "Two Proteins Containing Tandem DIII Domains, Calpain 10 and Dictyostelium Cpl, are Involved in Cytoskeletal Regulation." Connect to Online Resource-OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1193689816.

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Dissertation (Ph.D.)--University of Toledo, 2007.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 117-147.

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2

Janardhanan, Anitha C. "Gene expression of components of the calpain system m-calpain, [mu]-calpain and calpastatin in male and female broiler skeletal muscle /." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=895.

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Thesis (M.S.)--West Virginia University, 1999.<br>Title from document title page. Document formatted into pages; contains vii, 93 p. : ill. (some col.) Includes abstract. Includes bibliographical references (p. 72-80).

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3

Fernández-Montalván, Amaury Ernesto. "Structural requirements for activation and membrane binding of human m-calpain [mu-calpain]." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973390123.

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4

Schroeder, Ewald. "Structural studies of #mu#-calpain, a novel calpain substrate, and a papain-leupeptin complex." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386677.

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5

Huang, Xinhua. "DIII Domain of Calpain 10 and Cpl Towards an Understanding of Calpain 10 Function." University of Toledo Health Science Campus / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=mco1096641027.

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6

Huang, Xinhua. "DIII domain of calpain 10 and Cpl towards an understanding of calpain 10 function /." Connect to full-text via OhioLINK ETD Center, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1096641027.

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Thesis (Ph. D.)--Medical College of Ohio, 2003.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Ronald Mellgren. Includes abstract. Document formatted into pages: iv, 126 p. Title from title page of PDF document. Includes bibliographical references (p. 92-124).

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7

Rose, Robert Edward. "Calpain and lipopolysaccharide mediated hepatitis." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1806.

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8

Plammootil, Salma Martha. "Mutationen im Calpain-3-Gen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973536306.

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9

Douillard, Aymeric. "Implication des calpaïnes lors d'un remodelage musculaire induit par un traitement chronique au clenbutérol." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON14001/document.

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Afin de lutter efficacement contre les malversations du dopage, il apparaît essentiel de comprendre les mécanismes conduisant au remodelage musculaire. Dans ce but nous avons analysé les effets d’un β2-agoniste, le clenbutérol, sur le remodelage musculaire et les différentes voies de signalisation qui y sont associées. Nous nous sommes particulièrement intéressés au système des calpaïnes qui a souvent été associé à des phénomènes de remodelage musculaire, principalement dans des modèles d’atrophie. Nous avons montré une sollicitation précoce du système des calpaïnes lors d’un traitement chroni

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10

Arthur, John Simon Campbell. "Regulation of m-calpain by phospholipids." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240569.

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11

Joshi, Aashish. "SUBSTRATE AND REGULATION OF MITOCHONDRIAL μ-CALPAIN". UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/80.

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μ -Calpain is localized to the mitochondrial intermembrane space. Apoptosisinducing factor (AIF), which executes caspase-independent cell death, is also localized to the mitochondrial intermembrane space. Following processing at the N-terminus, AIF becomes truncated (tAIF) and is released from mitochondria. The protease responsible for AIF processing has not been established. The same submitochondrial localization of mitochondrial μ-calpain and AIF gives support to the hypothesis that mitochondrial μ-calpain may be responsible for processing AIF. Atractyloside-induced tAIF release in rat liver

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12

Chen, Hongyuan. "Design, synthesis and testing of calpain inhibitors for the treatment of cataract." Thesis, University of Canterbury. Chemistry, 2007. http://hdl.handle.net/10092/1405.

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This thesis reports the development of potent and selective inhibitors of m-calpain for the treatment of cataract. SJA6017 has been proven to prevent lens opacity in rat and has been our lead compound. A series of Val-Leu peptidyl aldehyde inhibitors (33a-e, 33g, 33i and 35) have been designed, synthesized, and tested for therapeutic potential as cataract inhibitors. Chapter 1 is an introduction to calpain and the diseases associated with it's over activation. A review of the literature on calpain inhibition is given. Structure activity relationship (SAR) theory is presented. The techni

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13

Singh, Ranjana. "CALPAIN 5: A NON-CLASSICAL CALPAIN HIGHLY EXPRESSED IN THE CNS AND LOCALIZED TO MITOCHONDRIA AND NUCLEAR PML BODIES." UKnowledge, 2014. http://uknowledge.uky.edu/neurobio_etds/9.

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Calpain 5 (CAPN5) is a non-classical member of the calpain family. It lacks the EF-hand motif characteristic of the classical calpains, calpain 1 and 2, but retains catalytic and Ca2+ binding non EF domains. Tra-3, an ortholog of CAPN5, is involved in necrotic cell death in C.elegans; although specific role of CAPN5 has not been investigated in the mammalian CNS. I compared relative mRNA levels of calpains in rat CNS, which revealed that CAPN5 is the second most highly expressed calpain. We examined relative levels of CAPN5 from late embryonic day 18 to postnatal day 90 and found lower mRNA bu

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14

Fraser-Smith, Emma Louise. "Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure". The University of Waikato, 2006. http://hdl.handle.net/10289/2253.

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Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that we understand the mechanism of meat tenderisation of which, the calpain protease system is believed to play a central role. This thesis focuses on three aspects; characterisation of calpain activity, the effect of porcine μ-calpain on myofibril degradation and the effect of μ-calpain on specific proteins desmin and troponin-T. To study the eff

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15

Sazili, Awis Qurni. "Calpastatin and meat tenderness in sheep and cattle." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273257.

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16

Ishak, Reezal. "Calpain-1 : investigating its role in murine neutrophils." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/37448/.

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Neutrophils are phagocytic white blood cells which act as the first line of defence against entry of foreign microorganisms. Neutrophils are recruited to their target site through the process of spreading, extravasation and phagocytosis involving complex signal transduction within the cells, which might include the activation of the cytosolic Ca2+ activated protease, calpain-1. The work described here investigates the role of calpain-1 in regulating neutrophil functions such as spreading, trans-endothelial migration, chemotaxis, phagocytosis and Ca2+ signalling. Through the work done at Europe

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17

Olego-Fernandez, S. "A calpain-like multigene family in Trypanosoma brucei." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:5256ea6f-4da0-4d42-b77c-a0d2da6f3af2.

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Trypanosomatid parasites are unicellular eukaryotes characterised by the presence of a subpellicular array of microtubules, a single flagellum, and a kinetoplast (containing the condensed mitochondrial DNA). The majority of trypanosomatid species undergo complex life-cycles, alternating between a mammalian host and an insect vector. Progression through this life-cycle requires the differentiation of trypanosomatids into distinct, niche adapted developmental forms. Differentiation into each life-cycle stage involves important biochemical and morphological changes, including the remodelling of t

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18

Zhang, Siwei. "Calpain in ovarian cancer progression and chemotherapeutic response." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/51279/.

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The calpain system is associated with cancer chemotherapeutic response in both in vivo and in vitro studies. Previous immunohistochemistry (IHC) data conducted in our group indicated that high calpain-2 expression was associated with both the resistance to platinum-based adjuvant chemotherapy and worse patient outcome; moreover calpain-2 appeared as an independent prognostic factor in multivariate analysis. To test the hypothesis that conventional calpain subunits, especially calpain-2, are associated with the chemo-resistance of ovarian cancer cells to platinum-based chemotherapy (cisplatin a

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19

Wan, Feng. "[Rôle du sytème calpaïne /calpastatine dans le remodelage cardiovasculaire]." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST0067.

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Rôle du Système de calpaïne/calpastatine dans l'hypertension pulmonaire induite par l'hypoxie chez la souris. Les souris calpaïnes knockout ont montré des effets protecteurs dans l'hypertension pulmonaire (HP) induite par l'hypoxie. Cependant, le modèle animal avec une surexpression de calpastatine (cast) n'a jamais été étudié. Notre objectif est d'utiliser des souris transgéniques CMV-cast qui surexpriment constitutivement la calpastatine intracellulaire sous le contrôle du promoteur CMV dans tous les types cellulaires pour étudier les effects de la calpaïne intracellulaire. Nous utilisons au

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20

Hewitt, Kimberley E. "The role of calpain in excitotoxic neuronal cell death." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0017/NQ46523.pdf.

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21

Adams, Sarah Elizabeth. "The synthesis and evaluation of novel calpain-I inhibitors." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/53271/.

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The calcium activated cysteine protease calpain-I has a pivotal role in a variety of physiological processes within the human body. In particular calpain-I enables the cell spreading and subsequent chemotaxis behaviour of neutrophils in response to tissue damage. Neutrophils are linked to the pathological condition rheumatoid arthritis and so calpain-I is considered be a valuable therapeutic target. Many inhibitors of calpain-I are highly non-selective with the exception of two small molecule synthetic inhibitors. A phenyl and an indole-based α-mercaptoacrylic acid have shown a slight selectiv

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22

Chen, Hongyuan. "Development of macrocyclic β-strand calpain cysteine protease inhibitors". Thesis, University of Canterbury. Chemistry, 2011. http://hdl.handle.net/10092/5582.

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The work in this thesis reports studies directed to developing a calpain cysteine protease inhibitor that could be of value in slowing cataract development in humans. The work focuses on the development of macrocyclic compounds which can have advantages over acyclic compounds due to their resistance to proteolytic hydrolysis, improved selectivity, bioavailability and membrane permeability. A review of X-ray crystal structures of natural and synthetic calpain inhibitors complexed with the cysteine protease calpain show the inhibitors generally bind in the enzyme active site in an extended β-str

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23

Norton, Luke. "Calpain-10 and insulin resistance in human skeletal muscle." Thesis, University of Nottingham, 2007. http://eprints.nottingham.ac.uk/11536/.

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Variation in the calpain-10 gene has been linked to a three-fold increased risk for type 2 diabetes in Pima Indian and some European populations. Furthermore, reduced skeletal muscle expression of calpain-10 is associated with reduced insulin mediated glucose disposal and carbohydrate oxidation. The skeletal muscle specific calpain-3 plays a key role in skeletal muscle integrity and has also been linked to insulin resistance in humans and rodents. The major aims of this thesis were to 1) investigate the hypothesis that alterations in insulin sensitivity in healthy humans would lead to signific

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24

Parr, Timothy. "Calpain proteinase mRNA and beta-agonist induced muscle growth." Thesis, University of Nottingham, 1991. http://eprints.nottingham.ac.uk/11445/.

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The mechanism by which β-agonists induce skeletal muscle hypertrophy is believed largely to be through a reduction in protein degradation. These growth promoters are also known to effect the activity of the calcium dependent proteinases (calpains) and their specific endogenous inhibitor calpastatin. The changes in activity appear to be toward a decrease in the calpain system's proteolytic potential. In this study attempts were made to determine whether the altered activity of the enzymes and inhibitor were brought about by induced changes in gene expression as reflected by altered levels of sp

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25

Liu, Wen. "The characterisation of calpain-like proteins in Trypanosoma brucei." Thesis, University of Hull, 2010. http://hydra.hull.ac.uk/resources/hull:6899.

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Calpains are a ubiquitous family of calcium-dependent cysteine proteases involved in a wide range of cell regulatory and differentiation processes. In many protozoan organisms, atypical calpains have been discovered that lack the characteristic calcium-binding penta-EF-hand motif of typical vertebrate calpains and most of these novel calpain-like proteins are non-enzymatic homologues of typical calpains. The gene family is particularly expanded in ciliates and kinetoplastids, comprising 25 members in the parasite Trypanosoma brucei. Unique to kinetoplastids, some calpain-like proteins contain

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26

Joyce, Peter. "Characterisation of the atypical calpain family of C elegans." Thesis, University of Bristol, 2008. http://hdl.handle.net/1983/fd3f92bf-ab35-4564-84d8-f36227fc0640.

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Regulated proteolysis plays an important role in modulating the activities of receptors, cytoskeletal proteins and transcription factors during cell growth and development. A family of calcium-regulated thiol proteases, known as calpains, has been shown to promote this process in mammals, and other eukaryotes. The importance of calpains is highlighted through their involvement in a number of pathologies in humans.

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27

Drouet, Saltos Domenica Elizabeth. "Calpain-Calpastatin System in Peripheral Nerve Myelination and Demyelination." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1559220437439116.

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28

Redpath, Gregory. "Calpain cleavage and subcellular characterisation of the ferlin family." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14278.

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The ferlins are a family of C2-domain containing proteins. C2 domains regulate vesicle fusion in synaptotagmins, and animal models of ferlin deficiency display pathologies related to Ca2+-dependent vesicle fusion. Dysferlin mutations cause limb-girdle muscular dystrophy due to defective membrane repair. Our group has previously shown that Ca2+-dependent proteases, calpains, cleave dysferlin following membrane injury, releasing mini-dysferlinC72, that we hypothesise mediates membrane repair. Otoferlin mutations cause non-syndromic deafness, while no pathology causing mutations have been identif

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29

Robilotto, Anthony T. "Calpain activation following cryopreservation an initial investigation into their roles in cell death and cell adhesion /." Diss., Online access via UMI:, 2005. http://wwwlib.umi.com/dissertations/fullcit/1425587.

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Klanchantra, Mutita. "Design and synthesis of beta-strand conformationally constrained calpain inhibitors for cataract treatment via metathesis ring closure." Thesis, University of Canterbury. Chemistry, 2006. http://hdl.handle.net/10092/1609.

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This thesis summarises the progress made in the design and synthesis of conformationally constrained β-strand peptidomimetic compounds using ring closing metathesis methodology under microwave irridation conditions. The best macrocycle were elaborated into an inhibitor for a specific protease target. Calpain was used as an example of protease targeting cataract disease. Chapter One introduces proteases in general centring on the general context of protease inhibitor design. The significant of the β-strand 'bioactive' conformation is discussed in details in particular the exploitation of confor

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31

Kim, Hyun Woo. "Characterization of genes involved in molting and limb regeneration in land crab, Gecarcinus lateralis." Access citation, abstract and download form; downloadable file 6.77 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131680.

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Hanouna, Guillaume. "Rôle des calpaïnes dans le vieillissement et la réponse anti-tumorale." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066385/document.

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Les calpaïnes 1 et 2 sont des protéases à cystéine ubiquitaires et la calpastatine est leur inhibiteur naturel, également ubiquitaire. Les calpaïnes sont impliquées dans le développement de la réponse inflammatoire via l’activation par protéolyse partielle de plusieurs substrats (activation de NF-κB par le clivage de I-κBα, remodelage du cytosquelette des cellules inflammatoires, clivage de la protéine chaperonne HSP 90…).Il a été précédemment démontré que les calpaïnes favorisent le vieillissement neuronal. Nous avons pu montrer dans un modèle murin que l’inhibition in vivo des calpaïnes par

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33

Vanhooser, Lisa M. "Engineering Calpastatin to Develop a Sensor to Detect Active Calpain." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/VanhooserLM2006.pdf.

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34

Nakagawa, Yasuaki. "Calcium-Dependent Neutral Proteinase(Calpain)in Fracture Healing of Rats." Kyoto University, 1994. http://hdl.handle.net/2433/168857.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第5555号<br>医博第1525号<br>新制||医||577(附属図書館)<br>UT51-94-C13<br>京都大学大学院医学研究科外科系専攻<br>(主査)教授畑中正一, 教授岡正典, 教授山室隆夫<br>学位規則第4条第1項該当

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35

Davis, Benjamin. "Genetic and Functional Analysis of Calpain-14 in Eosinophilic Esophagitis." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447688593.

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36

Pasalic, Dario. "No Calpain, No Gain: Newly Developed Procedures for the Separation and Characterization of The Calpain Family of Proteins in Human Dystrophic and Non-dystophic Muscle." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146022.

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Muscular dystrophy is a disease which gradually deteriorates skeletal muscle cells, leading to the eventual death of such cells and the surrounding tissue. Calpains are Ca2+- dependent proteases and together with the Ca2+-dependent specific inhibitor of calpains, calpastatin, are widely distributed in eukaryotic cells. It has been suggested that part of the enhanced deterioration in the dystrophic state is due to enhanced calpain activity; therefore analysis of normal and dystrophic muscle was essential. Conventional techniques for the isolation and characterization of calpain and calpastatin

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37

Mazon, Madeline Rezende. "Efeitos da Imunocastração e de agonistas beta-adrenérgicos sobre a qualidade da carne de bovinos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-18052016-095207/.

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Os agonistas beta-adrenérgicos (βAA) são conhecidos por aumentar a hipertrofia muscular e lipólise, neste caso uma maneira de se reduzir o efeito da lipólise seria a imunocastração. Dessa forma, o objetivo deste projeto foi avaliar o efeito dos βAA e da imunocastração sobre a qualidade da carne de bovinos Nelore. Foram utilizados noventa e seis bovinos Nelore, sendo que metade dos animais (n=48) receberam uma dose da vacina de imunocastração, e após 30 dias receberam a segunda dose. A outra metade dos animais (n=48) não recebeu nenhuma dose da vacina. Durante 70 dias os animais foram

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38

Millar, Tarek Lawson. "Synthesis and evaluation of CA clan cysteine inhibitors." Thesis, University of Canterbury. Chemistry, 2008. http://hdl.handle.net/10092/1911.

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This investigation involved the synthesis of potential CA clan cysteine inhibitors of m-calpain and cathepsin B. Inhibitors 2.1.3a-j were based on the SJA-6017 construct containing the N-(4-fluorobenzenesulfonyl) moiety at the P₃ address region. The inhibitor 2.1.3k was based on CAT-0059 a novel dipeptide dialdehyde inhibitor containing the 5-formyl pyrrole moiety at the P₃ address region. Chapter 1 introduces proteases in particular m-calpain and cathepsin B implicated in human pathologies cataract and tumour metastasis respectably. Structure, disease processes and known inhibitors for m-calp

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Stuart, Blair Gibb. "Molecular Modelling for Enzyme Inhibition: A Search for a New Treatment for Cataract and New Antimicrobials and Herbicides." Thesis, University of Canterbury. Chemistry, 2010. http://hdl.handle.net/10092/4551.

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There have been several reports that cataract development results from unregulated Ca2+ mediated degradation of lens crystallins. The calpain isoform m-calpain, a cysteine protease, is known to be a major player in cataract formation in rodent lenses and recent evidence indicates that over-activation by Ca2+ causes cataractogenesis in other mammals. Molecular modelling studies of seventeen analogues of compound SJA6017 (our lead compound) in a calpain model are compared to measured IC50 values against ovine calpain. The studies validated the potential of the ‘model’, method and defined activi

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40

Draper, Kati Elizabeth. "Increased structure-bound proteolytic activity in maturing dystrophic skeletal muscle." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/31735.

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Duchenne Muscular Dystrophy (DMD) is a severe X-linked progressive muscle wasting disease resulting from the absence of the membrane-associated protein dystrophin and the secondary components of the dystrophin-glycoprotein complex. Although the genetic basis of the disease has been known for over 15 years, the onset mechanism of the disease is not yet known and no treatment is yet available to significantly increase the lifespan of DMD patients. Increased levels of intracellular calcium have been noted in dystrophic muscle (Turner et al., 1991) and increased intracellular levels of calcium

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41

Wang, Qiong. "The activity and content of calpains in maturing dystrophic muscle membranes." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/42729.

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Increased calcium-activated calpain proteolysis in the sarcolemma membrane is thought to be a primary mechanism in the pathophysiology of Duchenne Muscular Dystrophy (DMD). However, few studies have tested this possibility prior to the overt signs of the dystrophy. The purpose of this study was to test the hypothesis that there is greater calpain content and total relative calpain activity in membranes obtained from dystrophic (mdx; mdx:utrophin-deficient (mdx:utrn-/-)) compared to wildtype (wt) mouse skeletal muscles during maturation at ages 7- and 21-d,and at a post-maturation age of 35-d.

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42

Sun, ChunHui. "Régulation des réponses calciques et de la cytotoxicité par l’effecteur de type III IpgD durant l’invasion des cellules épithéliales par Shigella." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS179.

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Shigella, l’agent de la dysenterie bacillaire, envahit la muqueuse colique, causant une inflammation intense et destruction tissulaire. Afin de promouvoir l’infection, Shigella injecte des facteurs de virulence par l’intermédiaire d’un appareil de sécrétion de type III (T3SS) dans les cellules hôte, qui permettent la réorganisation du cytosquelette d’actine, régulent l’inflammation et l’intégrité du tissu. Parmi ces facteurs injectés par la bactérie, la protéine IpgD agit comme une phosphatidylinositol (PI) (4,5) bisphosphate phosphatase déphosphorylant le PIP2 en PI(5)P. L’hydrolyse du PI(4,5

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Allcock, Stephen M. J. "Interactions between calpain proteases #beta#-adrenergic receptor and skeletal muscle growth." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358286.

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Liu, Zhao. "PALMITATE INDUCED ENDOTHELIAL DYSFUNCTION: THE ROLE OF CALPAIN, AMPK AND ENOS." Master's thesis, Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/288932.

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Physiology<br>M.S.<br>Obesity is a serious health problem worldwide. Consumption of fat rich food is a common cause of obesity. Some of the food components (i.e. saturated free fatty acids (SFAs)) have been identified as inflammatory inducers (Egger G at al., 2010). After a meal, absorbed free fatty acids (FFAs) will be stored in the liver and adipose tissue. On the luminal surfaces of endothelium in adipose tissue microcirculation, lipoprotein lipase hydrolyses absorbed triglycerides into FFAs. Then, in order to be available for adipocyte storage, FFAs have to cross the capillary endothelium

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Cataldo, Francesca. "Role of calpain in USP1 stability regulation and genome integrity maintenance." Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7860.

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2010/2011<br>The calpains are a family of intracellular cysteine proteases, among which the best studied isoforms, micro- (CAPN1) and milli-calpain (CAPN2), are heterodimers consisting of a catalytic subunit and a common regulatory subunit, CAPNS1, required for function. Calpain is involved in many processes important for cancer biology, such as autophagy, indeed in calpain-depleted cells autophagy is impaired, with a subsequent increase in apoptosis sensitivity. Calpain is also important in all the stages of the stress response. A proteomic approach was employed for the identification of nov

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MARCASSA, ELENA. "Dissection of the role of calpain in the regulation of autophagy." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908036.

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Lo scopo principale del progetto di dottorato è stato quello di studiare il ruolo delle calpaine ubiquitarie nella regolazione del processo autofagico. Differenti tecniche biochimiche, di microscopia confocale e elettronica, ci hanno portato all'identificazione di una proteina target della micro-calpaina: Bif-1. L'azione proteasica su Bif-1 sembra sia indispensabile per la fissione e il trasporto di porzioni del Golgi verso il sito di formazione dell'autofagosome.

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Nettersheim, Jo-Ann. "Interplay between the translesion DNA polymerase η and the calpain system". Electronic Thesis or Diss., Strasbourg, 2020. http://www.theses.fr/2020STRAJ078.

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L’ADN est constamment altéré du fait du métabolisme oxydatif de la cellule ou de l’exposition à des agents génotoxiques. Malgré l’existence de systèmes de réparation efficaces, certaines lésions présentes lors de la phase S bloquent la progression des fourches de réplication. La synthèse translésionnelle (TLS) permet la reprise de la réplication. Pol η est une ADN polymérase TLS capable de franchir et sans erreur les lésions induites par les UV mais pol η est mutagène lorsqu’elle réplique l'ADN non endommagé. Par conséquent, son activité doit être strictement régulée. La thèse présente l’étude

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Andrique, Caroline. "La calpaine- 6 identifie et maintient la population de cellules souches des necones osseux en contrôlant les processus d'autophagie et de sénescence." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC306/document.

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Les cellules souche cancéreuses contribuent au développement des sarcomes, mais le manque de marqueurs spécifiques empêche leur caractérisation et la possibilité de cibler ce type de cellules. Nous avons utilisé la séquence régulatrice de la calpaïne-6 dans des systèmes rapporteurs pour identifier les cellules exprimant la calpaïne-6. Ces cellules étaient des cellules initiatrices de tumeurs et se comportaient comme des cellules souche, au sommet de la hiérarchie cellulaire. L'expression de la calpaïne-6 dépend d’un programme génique de cellules souche qui implique Oct4, Nanog et Sox2 et est a

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Carvalho, Minos Esperândio. "Caracterização da freqüência de polimorfismos em genes ligados à maciez da carne em bovinos da raça Nelore." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-23062008-082501/.

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O objetivo deste trabalho foi avaliar o potencial de utilização de marcadores moleculares em genes candidatos da calpaína (CAPN) e calpastatina (CAST) como ferramenta auxiliar para programas de melhoramento de características relacionadas ao crescimento e maciez da carne. Foram avaliados 605 bovinos da raça Nelore, pertencentes à Agropecuária CFM Ltda, com idade média ao abate de 24 meses. Após a extração do DNA de amostras de sangue, por desproteinização em presença de NaCl, a identificação e determinação do polimorfismo para os marcadores moleculares CAPN316, CAPN530, CAPN4751, CAPN4753 e UO

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Xu, Jin. "Synthesis of novel sulfonamide-based calpain inhibitors and their potential as anti-tumor agents." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/WORLD-ACCESS/Xu/2007-028-Xu.pdf.

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Thesis (M.S. )--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on July 28, 2008). Research advisor: Dr. Isaac O. Donkor, Ph.D. Document formatted into pages (xii, 80 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 65-80).

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