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Rozprawy doktorskie na temat „Cancer cell microenvironment”

Autor: Grafiati

Data publikacji: 2 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

YOUSAFZAI, MUHAMMAD SULAIMAN. "Cancer cell mechanics and cell microenvironment: An optical tweezers study." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908097.

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Since cancer metastasis is a complex process, lot of research has been carried out to identify different hallmarks for its diagnosis and cure. Mechanical alterations in cancer cells during cell spreading to adjacent tissues and other organs of the body emerged as a prominent hallmark in the last decade. In this thesis we employed a mechanistic approach and used stiffness (elasticity) as a marker to study cell’s mechanical response in varying microenvironmental conditions. Cell– microenvironment mechanical interaction is a blend of cell-matrix and cell-cell interactions. Therefore we adopted

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Hodkinson, Philip Simon. "Tumour microenvironment interactions of small cell lung cancer." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4254.

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Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, this response is often short-lived and SCLC recurs with acquired drug resistance, resulting in early patient death. Despite intensive chemo- and radiotherapy regimes survival has not improved significantly in 20 years. Prior research suggests a critical role for the tumour microenvironment in the pathogenesis of other cancers. Therefore, investigating interactions between

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Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.

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Breast carcinoma is the most commonly diagnosed cancer among women worldwide, with approximately 1 in 7 expected to be affected during her lifetime. The spread of breast cancer to secondary sites is generally incurable. Bone is the preferred site of metastasis, where the development of a secondary tumour causes severe osteolysis, hypercalcemia and a considerable pain burden. However, how breast cancer cells establish supportive interactions with bone cells is not well understood. We have examined the effects of factors released from MDA-MB-231 and 4T1 breast cancer cells on the differentiation

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Daukšte, Liene. "Mathematical Modelling of Cancer Cell Population Dynamics." Thesis, University of Canterbury. Mathematics and Statistics, 2012. http://hdl.handle.net/10092/9356.

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Mathematical models, that depict the dynamics of a cancer cell population growing out of the human body (in vitro) in unconstrained microenvironment conditions, are considered in this thesis. Cancer cells in vitro grow and divide much faster than cancer cells in the human body, therefore, the effects of various cancer treatments applied to them can be identified much faster. These cell populations, when not exposed to any cancer treatment, exhibit exponential growth that we refer to as the balanced exponential growth (BEG) state. This observation has led to several effective methods of estimat

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Truong, Danh, Julieann Puleo, Alison Llave, Ghassan Mouneimne, Roger D. Kamm, and Mehdi Nikkhah. "Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/621806.

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In this study, to model 3D chemotactic tumor-stroma invasion in vitro, we developed an innovative microfluidic chip allowing side-by-side positioning of 3D hydrogel-based matrices. We were able to (1) create a dual matrix architecture that extended in a continuous manner, thus allowing invasion from one 3D matrix to another, and (2) establish distinct regions of tumor and stroma cell/ECM compositions, with a clearly demarcated tumor invasion front, thus allowing us to quantitatively analyze progression of cancer cells into the stroma at a tissue or single-cell level. We showed significantly en

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Giraldo-Castillo, Nicolas. "The Immune Microenvironment in Clear Cell Renal Cell Carcinoma : The heterogeneous immune contextures accompanying CD8+ T cell infiltration in clear cell Renal Cell Carcinoma." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066321/document.

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Dans cette étude, nous avons tenté de décrypter les mécanismes reliant l’augmentation de lymphocytes infiltrant les tumeurs (LIT) T CD8+ et un pronostic clinique défavorable dans le cancer du rein à cellules claires (ccRCC). Pour cela, nous avons déterminé 1) la relation entre le pronostic associé à l'expression d’immune checkpoints et l’infiltrat de cellules dendritiques (DC) et de LT CD8+ et 2) les caractéristiques phénotypiques des LIT T CD8+. L’expression des immune checkpoints a été déterminée par immunohistochimie dans une cohorte de 135 ccRCC. Nous avons constaté que les densités des ce

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Kaira, Mustapha. "In situ molecular profilling of the microenvironment of breast carcinoma." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265258.

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High stromal PDGF receptor B expression was shown to have strong prognostic value in a studyinvolving over 600 breast cancer patients however, the molecular role of the receptor in tumordevelopment remains unclear. In this project we studied the spatial distribution and expressionlevels of a panel genes and markers associated with PDGF signaling, in breast cancer tumormicroenvironment (TME) using a newly developed technique -in situ sequencing. The techniquerelies on padlock probes which we validated with corresponding RNA sequencing, microarray,and immunohistochemistry data. Our results showe

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Xing, Fei. "ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/514.

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Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor progression. We have analyzed the expression profiles of various Notch liagnds in 779 breast cancer patients in GEO database and found that the expression of Jagged2 among all five

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Kiyasu, Yoshiyuki. "Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice." Kyoto University, 2020. http://hdl.handle.net/2433/259008.

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Sundquist, E. (Elias). "The role of tumor microenvironment on oral tongue cancer invasion and prognosis." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217659.

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Abstract Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. The 5-year mortality of OTSCC remains at about 50%. The tumor microenvironment (TME) is now recognized as an important factor in cancer progression and metastasis, as well as a tool for prognostication. The aim of this study was to elucidate the roles of TME hypoxia and soluble factors on cancer cell migration and invasion, and the prognostic value of two extracellular matrix (ECM) molecules: tenascin-C (TNC) and fibronectin (FN). Hypoxia was studied using oral squamous cell carcinoma cells in mi

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Wang, Yuan Yuan. "Deciphering the crosstalk between breast cancer cells and tumour-surrounding apidocytes : contribution of cell metabolic symbiosis." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2093/.

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Relativement peu d'attention a été accordée aux adipocytes matures qui représentent le type cellulaire majoritaire entourant le cancer du sein. Le rôle des adipocytes dans la progression tumorale est devenu d'une importance clinique majeure depuis qu'il a été montré que l'obésité est un facteur indépendant de mauvais pronostic dans le cancer du sein. Au cours de ma thèse, j'ai participé aux efforts de mon équipe visant à caractériser les changements phénotypiques induits par les cellules tumorales dans les adipocytes environnants la tumeur. Nous avons ainsi défini deux nouvelles populations de

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Wang, Elaine. "Warburg or reverse Warburg effect: Tumor microenvironment reprograms breast cancer metabolism to upregulate cell proliferation." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1966.

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Cancer cells are most clearly characterized by their abnormal and uncontrolled cell growth. One of the most notable theories that explains the vast proliferative capacity of tumorigenic cells is the Warburg effect, a significant shift in metabolism wherein cancer cells preferentially fuel cell division using aerobic glycolysis instead of aerobic respiration. This upregulation of glycolytic fermentation in aerobic environments is highly unusual - glycolysis is typically utilized in anaerobic conditions, but nonetheless dominates cancer metabolic activity in spite of the presence of oxygen. Sinc

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Hoffmann, Caroline. "Dendritic Cells in Head and Neck Cancer Microenvironment : From Mechanisms to Biomarkers." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS308/document.

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L’objectif de ce travail était de comprendre l’état moléculaire des cellules dendritiques (CD) dans le microenvironnement tumoral. En intégrant l’analyse de tumeurs humaines par cytométrie en flux, de transcriptome, de secretome tumoral et l’analyse d’une base de données d’interaction CD-lymphocyte T générées in vitro, j’ai obtenus 2 résultats majeurs. Tout d’abord, nous proposons une nouvelle classification de CD activées humaines, qui sont soit « secrétantes », c’est-à-dire spécialisées dans la production de cytokines et chemokines, soit « aidantes » c’est-à-dire spécialisées dans l’inductio

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14

Smigiel, Jacob. "ONCOSTATIN M & TRANSFORMING GROWTH FACTOR SIGNALING CONVERGE TO REGULATE CANCER CELL PLASTICITY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case152891618991579.

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Nishikawa, Gen. "Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5." Kyoto University, 2019. http://hdl.handle.net/2433/244520.

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Pearce, Janina V. "The Role of Tumor and Tumor Microenvironment on Breast Cancer-Associated Adipocyte Plasticity." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5933.

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Cancer-associated cachexia is a condition defined by a sustained net-negative energy imbalance. Although the different types of adipose tissue – white, beige, and brown – have been implicated in contributing to cancer-associated cachexia, the mechanisms of these maladaptive changes and their impact on whole-body energy expenditure have not been fully elucidated. Using breast cancer as our model, we demonstrate white adipose tissue browning in murine and human breast cancer; furthermore, we demonstrate that this effect is extremely localized and takes place early in tumor progression. We utiliz

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Diwanji, Neha. "Role of Tissue Microenvironment in Recruiting Macrophages During Apoptosis-induced Proliferation." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1084.

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Apoptosis-induced compensatory proliferation (AiP) is a mechanism that maintains tissue homeostasis after stress-induced cell death. During AiP, apoptotic cells induce proliferation of the neighboring surviving cells to compensate for tissue loss. AiP is important for wound healing and tissue regeneration in several model organisms. Additionally, AiP is an important feature of tumorigenesis and tumor relapse as it contributes to tumor repopulation following radiation or chemotherapy. Using an overgrowth tumor model (“undead tissue”) in Drosophila melanogaster, we determined that the initiator

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Alahuhta, I. (Ilkka). "The microenvironment is essential for OTSCC progression." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526213583.

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Abstract The tumor microenvironment (TME) is critically important for tumor development. The microenvironment consists of fibroblasts, endothelial and immune cells as well as extracellular matrix (ECM), proteases and various other soluble factors produced by the cells. It is challenging to develop methods that appropriately mimic the human microenvironment, but this effort is essential in order to reliably elucidate the properties of potential anti-tumor drugs. The aim of this study was to create new 3D organotypic invasion models based on human tissue that would be used to study the effects o

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Eduardo, Rodrigo. "Exploring Tumor Macrophage Interaction in Anaplastic Thyroid Cancer." Master's thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier, 2019. http://hdl.handle.net/10362/130111.

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"Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer, with very high mortality rate. Tumor-associated macrophages (TAMs) can represent up to 70% of ATC’s tumor mass, making them an interesting target for novel therapies. In this thesis, the aim was to further understand the crosstalk between ATC and TAMs. To achieve that, cell surface proteomics of two ATC cell lines (C3948 and T235), in mono- or co-culture with THP-1-derived macrophage-like cells, was performed. The protein Spry-4, an inhibitor of the MAPK-ERK pathway, was found to be downregulated in C3948 cells up

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Rogon-Lamparski, Zbigniew [Verfasser], and Roland [Akademischer Betreuer] Eils. "Reverse engineering of gene regulatory networks governing cell-cell communication in the microenvironment of pancreatic cancer / Zbigniew Rogon-Lamparski ; Betreuer: Roland Eils." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179230086/34.

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Landry, Benjamin D. "Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/1011.

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Tumor heterogeneity observed between patients has made it challenging to develop universal or broadly effective cancer therapies. Therefore, an ever-growing movement within cancer research aims to tailor cancer therapies to individual patients or specific tumor subtypes. Tumor stratification is generally dictated by the genomic mutation status of the tumor cells themselves. Importantly, non-genetic influences – such as interactions between tumor cells and other components of the tumor microenvironment – have largely been ignored. Therefore, in an effort to increase treatment predictability and

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Jacquemin, Guillaume. "L'échec de l'homéostasie intestinale normale sous l'influence de signaux de paracrine dérivés de cellules tumorales." Electronic Thesis or Diss., Paris Sciences et Lettres (ComUE), 2019. https://theses.hal.science/tel-02873486.

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L'homéostasie épithéliale et la tumorigénèse sont deux concepts étroitement liés. En effet, la formation d’une tumeur et son évolution vers le cancer sont la conséquence d’une perte de contrôle des interactions spatiales et mécaniques des cellules épithéliales avec leur environnement. Ces altérations de l’homéostasie peuvent avoir deux origines : une origine intrinsèque, souvent due à des mutations, où la cellule perd sa capacité à interpréter correctement les signaux environnementaux et une origine extrinsèque où l’environnement lui-même ne fournit plus d’informations cohérentes capables d’or

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Doherty, Mary Rose. "INTERFERON-BETA REGULATES CANCER STEM CELL PLASTICITY TO PROMOTE POSITIVE CLINICAL OUTCOME IN TRIPLE-NEGATIVE BREAST CANCER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1540926583593107.

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Nelson, Mark Tyler. "Biomimetic Electrospun Fibers for Cancer Cell Migration, Chemotaxis, andAnti-Metastatic Drug Testing." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429031970.

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Ramos, Grasieli de Oliveira. "O microambiente tumoral como fator modificador no processo de invasão e progressão tumoral no carcinoma espinocelular de origem bucal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/147112.

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INTRODUÇÃO: O carcinoma espinocelular de origem bucal (CEC) apresenta uma alta taxa de mortalidade devido à invasividade das células tumorais. A migração celular, principal evento da invasão e metástase, pode ser regulada tanto por fatores intrínsecos, como adesão e contratilidade celular, quanto extrínsecos, como composição, densidade e remodelagem da matriz extracelular (MEC). OBJETIVO: Avaliar o papel de elementos intrínsecos e extrínsecos sobre o processo invasivo do carcinoma espinocelular de origem bucal. MÉTODOS: Foi realizada imuno-histoquímica para as proteínas: Miosina II (isoformas

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Diaz, Herrero Alba. "Characterization of Tumor Immune Microenvironment in Human Diffuse Large B-cell Lymphoma." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL057.

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Le lymphome diffus à grandes cellules B (DLBCL) est le sous-type le plus fréquent de lymphome non hodgkinien (NHL), caractérisé par une prolifération anormale de cellules B matures. C'est une maladie agressive pour laquelle les stratégies thérapeutiques actuelles sont insuffisantes. Le microenvironnement tumoral (TME) est un réseau dynamique de cellules, molécules et des autres éléments qui entourent une tumeur. Ceux-ci tiennent un rôle prépondérant dans le développement du cancer, la réponse au traitement et la survie des patients. Étudier le TME chez les patients atteints de DLBCL est essent

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Bischof, Ashley Gibbs. "Extracellular Matrix as a Key Mediator of Mammary Tumor Cell Normalization." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10780.

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Some epithelial cancers can be induced to revert to quiescent differentiated tissues when combined with embryonic mesenchyme; however, the mechanism of this induction is unknown. This dissertation is based on the hypothesis that because extracellular matrix (ECM) plays a critical role during organ development in the embryo, it also may mediate the differentiation-inducing effects of embryonic mesenchyme on cancer cells. To test this hypothesis, I first optimized methods to isolate ECMs from whole tissues or cultured cells, and to repopulate them with cultured cells, using embryonic tooth as a

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Tulkki, Valtteri Heikki Juhani. "Oncostatin M receptor overexpression promotes tumour progression in squamous cell carcinoma, via hypoxia signalling and multiple effects on the tumour microenvironment." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275416.

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Cervical cancer still represents the fourth most common cause of cancer deaths in women worldwide. Human papilloma virus (HPV) infection plays a role in cervical carcinoma initiation, but other genomic changes are needed for pre-malignant abnormalities to fully develop to cancer. This often happens through genomic instability caused by the virus oncoproteins. Several integrative genomic analysis studies have found that one of the most common imbalances in cervical squamous cell carcinoma (SCC) is copy number gain and amplification of chromosome 5p. In this region, copy number gain of the OSMR

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Kamboj, Sahil. "Outils avancés pour la modulation du trafic des intégrines dans le cancer de l'ovaire." Electronic Thesis or Diss., CY Cergy Paris Université, 2024. http://www.theses.fr/2024CYUN1300.

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Les intégrines sont des récepteurs hétérodimériques de surface cellulaire qui jouent un rôle essentiel dans la gestion des interactions cellule-cellule, lesquelles influencent ensuite des processus biologiques à plusieurs échelles tels que le comportement cellulaire, le remodelage de la matrice extracellulaire et la formation des tissus. Ces processus s'étendent de quelques millisecondes à plusieurs jours. Les méthodologies existantes pour étudier la fonction des intégrines à différentes échelles biologiques - des cellules individuelles aux tissus entiers - s'avèrent souvent chroniques et manq

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McKenna, Mary Kathryn. "NOVEL ROLE OF PROSTATE APOPTOSIS RESPONSE-4 TUMOR SUPPRESSOR IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA." UKnowledge, 2017. https://uknowledge.uky.edu/microbio_etds/17.

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Chronic Lymphocytic Leukemia (CLL) is defined by the accumulation of clonally expanded CD5+ and CD19+ B lymphocytes in blood and secondary lymphoid organs with impaired apoptotic mechanisms. CLL represents one third of all leukemia cases with an average age of 72 years at diagnosis making it the most common adult leukemia. The Eµ-Tcl1 mouse serves as an excellent model to study the development of CLL as they progress to a CLL like disease by 9-14 months of age, due to overexpression of an oncogene, T cell Leukemia 1(Tcl1), specifically in B cells through the Ig VH promoter and Eµ enhancer (Bic

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Kashtl, Ghasaq J. "Differential membrane-type matrix metalloproteinase expression in phenotypically defined breast cancer cell lines: Comparison of MT-MMP expression in environmentally-challenged 2D monolayer cultures and 3D multicellular tumour spheroids." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17346.

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Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases capable of digesting the extracellular matrix (ECM), which is essential for tissue structure and transmitting messages between cells. MMPs play an important role in cancer, controlling cell migration, proliferation, apoptosis, regulation of tumour expansion, angiogenesis and invasion. Previous research has indicated high expression of MT1-MMP in breast cancers suggesting a potential role in tumour progression. Our results confirm that 3D multicellular tumour spheroids (MCTS) using phenotype-specific breast cancer cell lines a

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Ferreira, Luís Pedro Correia Pinto. "Development of multicelular 3D cancer testing platforms for evaluation of new anti-cancer therapies." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22713.

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Mestrado em Bioquímica Clínica<br>O cancro do pulmão (CP) é um dos cancros mais diagnosticados a nível mundial e também um dos mais mortíferos. Atualmente, as terapias administradas a nível clínico para o tratamento do CP são ainda extremamente ineficazes e limitadas no que diz respeito ao aumento da taxa de sobrevivência dos pacientes oncológicos. Esta realidade demonstra a necessidade de investigar ativamente novas terapias para o tratamento desta neoplasia. No entanto a validação pré-clínica de terapias inovadoras para o CP tem-se revelado extremamente difícil devido à inexistência de plat

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Ma, Yuting. "The crosstalk between dying tumor cells and immune effectors within tumor microenvironment elicited by anti-cancer therapies dictates the therapeutic outcome." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00636891.

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Besides exerting cytostatic or cytotoxic effects on tumor cells, some anti-cancer therapies (anthracyclines, oxaliplatin, X-Rays) could trigger an immunogenic cell death modality, releasing danger signals to alert immune system. We have shown that tumor-specific IFN- producing CD8+ T cells (Tc1) are mandatory for the success of chemotherapy to prevent tumor outgrowth. Priming of Tc1 response depends on IL-1β secretion by DC confronted with anthracycline-treated tumor cells releasing ATP. To identify the inflammatory components which link innate and cognate immune responses, we analyzed the in

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Liu, Huayang. "Cell Proliferation Control: from Intrinsic Transcriptional Programs to Extrinsic Stromal Networks." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1430953475.

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Seshadri, Dhruv Ramakrishna. "Immuno-nanotherapeutics to Inhibit Macrophage Polarization for Non-Small-Cell Lung Cancers." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case151084330337552.

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Adams, Rosie Louise. "The development of a novel 3D migration assay to study the effects of cell signalling and microenvironment on the migratory behaviour of colorectal cancer." Thesis, Durham University, 2015. http://etheses.dur.ac.uk/10962/.

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Colorectal cancer is one of the mostly commonly diagnosed cancers for both men and women in the UK, with a poor survival rate compared to other Western countries and other commonly diagnosed cancer types. Part of the reason for poor prognosis for patients is the diagnosis of the disease at an advanced stage of progression, which has been shown to have a severe impact on patient survival rates. Due to this, the signalling events surrounding the adoption of an invasive phenotype may provide the opportunity to develop therapies to limit the spread of tumours from their original site and improve p

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Yuting, Ma. "The crosstalk between dying tumor cells and immune effectors within tumor microenvironment elicited by anti-cancer therapies dictates the therapeutic outcome." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T033/document.

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En dehors des effets cytostatiques ou cytotoxiques sur les cellules tumorales, certaines thérapies anti-cancéreuses peuvent déclencher la mort cellulaire immunogénique, libérant les signaux de danger pour alerter le système immunitaire. Les cellules T CD8+ T (Tc1) productrices d’IFN- et spécifiques de la tumeur sont nécessaires pour le succès de la chimiothérapie et la diminution de la croissance tumorale. L’amorçage d’une réponse bénéfique Tc1 dépend de la sécrétion d'IL-1β par les cellules dendritiques confrontées à des cellules tumorales traitées avec de l’anthracycline libérant de l’ATP.

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Thareja, Gaurav. "Mapping the adaptive landscape of cancer cells using a multiomics approach." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL075.

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Le cancer est considéré principalement comme une maladie de la cellule. Certaines cellules cancéreuses acquièrent un avantage adaptatif sous la pression sélective d’un microenvironnement dynamique qui leur permet de surpasser les autres cellules cancéreuses, favorisant leur expansion. Par conséquent, ce travail de thèse vise à cartographier le paysage adaptatif des cellules cancéreuses à l’aide d’une approche multiomique.L’étude d’association pangénomique a montré l’effet des mutations germinales sur les niveaux d’expression 64 protéines cancéreuses listées dans OncoKB et a permis l’identifica

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Mola, Silvia. "Tumor Associated Macrophages (TAMs) a pivotal orchestrator in cancer-related inflammation and a new important target in cancer-therapy." Doctoral thesis, Università del Piemonte Orientale, 2021. https://hdl.handle.net/11579/127797.

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Macrophages are pivotal orchestrators of tumor-promoting inflammation and promising targets for new anti-cancer therapies. To identify new molecular players underlying their pro-tumoral activities, we analyzed the phosphoproteoma of tumor associated macrophages (TAMs) isolated from murine fibrosarcoma. We identified the protein TRIM28, a pleiotropic molecule that is known to be involved in the dynamic organization of chromatin, and we characterized the signaling pathway driving its phosphorylation in response to inflammatory signals and its impact on LPS-induced gene expression. We explored in

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Moreno, Lama Lucía 1993. "Understanding the immunomodulatory role of PARP proteins in the response against tumors." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668471.

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Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula tumoral. Sin embargo, la progresión de un tumor está muy determinada por su compleja interacción con otros múltiples tipos celulares, particularmente las células T, en las que no se está considerando la actividad de PARP. Superando la letalidad embrionaria de los ratones doble deficientes en PARP-1 y PARP-2, en el presente trabajo investigamos el papel de estas PARPs en la mo

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Hoque, Apu E. (Ehsanul). "Migration and invasion pattern analysis of oral cancer cells in vitro." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220239.

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Abstract Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but relatively little is known about its role in cancer. In this study, the function of Dsg3 was investigated in oral squamous cell carcinoma (SCC) cell lines in vitro using locally established human leiomyoma tumor microenvironment (TME) matrices. Since Dsg3 has been identified as a key regulator in cell adhesion, we hypothesized that it may play a role in oral SCC cells adhesion and motility. Thus, one aim of the study was to explore this hypothesis by both gain and loss of function methods in four human buccal mucosa SCC Sq

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Jalgaonkar, Swati. "An investigation of Atf3, an adaptive-response gene, in breast cancer chemotherapy and stress response." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460387137.

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Dolega, Monika Elzbieta. "Developement of microtechnologies for 3D cell culture to study prostate acini formation and carcinogenesis." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENS022/document.

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Tout épithélium glandulaire sécrétoire est constitué d'une unité structurale et fonctionnelle commune, l'acinus. C'est une architecture sphérique pluricellulaire parfaitement différentiée et polarisée qui, reconstruite en culture 3D, mime l'organisation réelle du tissu. Etudier les déterminants environnementaux et génétiques qui gouvernent la transformation d'un acinus en sphéroïde s'apparentant à une tumeur est l'un des enjeux majeurs des modèles in vitro. Un des défis actuels est d'adapter ces modèles in vitro à des conditions de culture 3D qui soient compatibles avec la réalisation de cribl

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Santos, Ana Paula Silva de Azevedo dos. "Efeito do microambiente tumoral sobre as características funcionais e fenotípicas de células dendríticas geradas in vitro a partir de monócitos do sangue periférico de voluntárias saudáveis e de pacientes com câncer de mama." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-13122010-112823/.

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No câncer de mama, o metabolismo tumoral, ação dos moduladores de estrógenos são fatores que podem influenciar as células dendríticas (DCs). Neste trabalho avaliou o fenótipo de DCs em amostras tumorais, a diferenciação de DCs a partir de células mononucleares do sangue periférico (PBMCs) das pacientes e comparou com voluntárias saudáveis. Os resultados mostraram que há alteração na capacidade de geração, no fenótipo, na capacidade aloestimuladora, maior produção de interleucina 10 e expressão de HSP27 nas DCs de pacientes, comparadas com as DCs de voluntárias saudáveis que produzem mais Inter

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Petitprez, Florent. "Integrated analysis and clinical impact of immune and stromal microenvironments in solid tumors Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine Transcriptomic analysis of the tumor microenvironment to guide prognosis and immunotherapies Tumor microenvironment quantification tool draws a comprehensive map of the tumor microenvironment of non-hematologic human cancers The mMCP-counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations using gene expression in murine samples Immune sub-classes in sarcoma predict survival and immunotherapy response Intra-tumoral tertiary lymphoid structures are associated with a low risk of hepatocellular carcinoma early recurrence Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer Immune-based identification of cancer patients at high risk of progression Tumor-infiltrating and peripheral blood T-cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma PD-L1 expression and CD8+ T-cell infiltrate are associated with clinical progression in patients with node-positive prostate cancer Intratumoral classical complement pathway activation promotes cancer progression". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB104.

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Les tumeurs sont composées de cellules malignes et d'une grande variété de cellules non-tumorales, en particulier des cellules immunitaires qui forment le micro-environnement tumoral (MET). Il a été démontré que la composition du MET était associée au devenir clinique des patients, en termes de survie et de réponses thérapeutiques. Avec le développement récent des immunothérapies qui ciblent des éléments spécifiques du MET, l'immunité anti-tumorale a soulevé un intérêt majeur. Plusieurs méthodologies ont été mises au point afin d'étudier la composition du MET, avec une précision toujours plus

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Bryson, Benjamin Levi. "The Paradoxical Roles of Oncostatin M in Mammary Epithelial Cell Senescence and Transformation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1510584483133814.

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Väyrynen, O. (Otto). "Factors affecting aggressive oral tongue cancer invasion and development of in vitro models for chemoradiotherapy assay." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222813.

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Abstract Tumor associated macrophages (TAMs) are linked to the invasion of oral tongue squamous cell carcinoma (OTSCC). We modified THP-1 leukemia cells to M1 (inflammatory), M2 (TAM-like) and R848 (imidazoquinoline-treated) type macrophages in order to examine their interactions with OTSCC-cells (HSC-3) by using different kinds of in vitro migration and invasion models. We observed that interaction of TAM-resembling M2-type macrophages with HSC-3 cells induced invasion and migration, whereas the influence of M1 macrophages reduced them. Patient response to chemoradiotherapy is highly reliant

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Bin, Saeedan Abdulaziz Saad Abdulaziz. "The role of MMP10 in non-small cell lung cancer, and pharmacological evaluation of its potential as a target for therapeutic intervention : investigation of the role of MMP10 in the tumour microenvironment of non-small cell lung cancer using gene, protein and mass spectrometry approaches to determine MMP10's potential in drug development strategies." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/14070.

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Bin, Saeedan Abdulaziz S. A. "The role of MMP10 in non-small cell Lung cancer, and pharmacological evaluation of its potential as a target for therapeutic intervention. Investigation of the role of MMP10 in the tumour microenvironment of non-small cell lung cancer using gene, protein and mass spectrometry approaches to determine MMP10’s potential in drug development strategies." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/14070.

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Non-Small Cell Lung Cancer (NSCLC), which accounts for 80% of all lung cancer cases, is associated with resistance to chemotherapy and poor prognosis. Exploitation of NSCLC-upregulated pathways that can either be targeted by novel therapeutics or used to improve the tumour-delivery of current chemotherapeutics are required. Among the matrix metalloproteinases (MMPs) that are essential for tumour development, MMP10 is a potential candidate as a therapeutic target based on its expression and contribution to NSCLC development. This research aims to explore the expression and functions of MMP10 in

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Lawrence, Mitchell Graham. "Crosstalk between developmental and tumour-specific signalling pathways : kallikrein-related serine peptidases and nodal in prostrate cancer." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/37184/1/Mitchell_Lawrence_Thesis.pdf.

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Prostate cancer is an important male health issue. The strategies used to diagnose and treat prostate cancer underscore the cell and molecular interactions that promote disease progression. Prostate cancer is histologically defined by increasingly undifferentiated tumour cells and therapeutically targeted by androgen ablation. Even as the normal glandular architecture of the adult prostate is lost, prostate cancer cells remain dependent on the androgen receptor (AR) for growth and survival. This project focused on androgen-regulated gene expression, altered cellular differentiation, and the ne

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