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Rozprawy doktorskie na temat „Cancer cells”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Sarvi, Sana. "Small cell lung cancer and cancer stem cell-like cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9542.

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Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often present with metastases, making surgery not feasible. Current therapies, rationally designed on underlying pathogenesis, produce in vitro results, however, these have failed to translate into satisfactory clinical outcomes. Recently, research into cancer stem cells (CSCs) has gained momentum and form an attractive target for novel therapies. Based on this concept, CSCs are the

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Fruka, Tayra. "An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines." University of the Western Cape, 2019. http://hdl.handle.net/11394/6920.

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Philosophiae Doctor - PhD<br>Introduction: Globally, there are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer is the second most diagnosed gynaecological malignancy and over all the fifth cause leading to death among all types of cancer in the UK in 2004. More than 70% of epithelial ovarian cancers are diagnosed at an advanced stage. Consequently, the prognosis is poor and the mortality rate high. Thus, the survival rate is affected by how far the disea

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Sasaki, Naoya. "Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics." Kyoto University, 2012. http://hdl.handle.net/2433/157414.

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Wong, Kit-man Sunny, and 王傑民. "Isolation and characterization of cancer stem cells in non-small cell lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47250665.

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Tumor heterogeneity has long been observed and recognized as a challenge to cancer therapy. The cancer stem cell (CSC) model is one of the hypotheses proposed to explain such a phenomenon. A specific cancer stem cell marker has not been determined for non-small cell lung cancers (NSCLC), preventing the definitive evaluation of whether the biology of NSCLC is governed by the CSC model. This study aimed to analyze the expression of candidate CSC markers and using the identified putative marker, to isolate CSC and determine the applicability of the CSC model in NSCLC. The expression or

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Liu, Qing. "Curcumin induces cell inhibition in breast cancer cells." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38688608.

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Liu, Qing, and 劉晴. "Curcumin induces cell inhibition in breast cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38688608.

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Oshima, Nobu. "Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors." Kyoto University, 2014. http://hdl.handle.net/2433/192147.

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Oshima N, Yamada Y, Nagayama S, Kawada K, Hasegawa S, et al. (2014) Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors. PLoS ONE 9(7): e101735. doi:10.1371/journal.pone.0101735<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第18547号<br>医博第3940号<br>新制||医||1006(附属図書館)<br>31447<br>京都大学大学院医学研究科医学専攻<br>(主査)教授千葉勉, 教授野田亮, 教授武藤学<br>学位規則第4条第1項該当

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8

Coulson-Gilmer, Camilla Lucette. "Cancer stem cells and chemoresistance in ovarian cancer." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18470/.

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The high mortality rate associated with epithelial ovarian cancer (EOC) is due to its insidious onset, leading to late diagnosis as well as eventual development of chemoresistance in the majority of patients. Cancer stem-like cells (CSCs) are thought to contribute to development of multi-drug resistant (MDR) tumours partly through their high level of ABC-transporter expression, which enables them to survive chemotherapy. ABC-transporter (MRP1, MRP2, BCRP, Pgp) and putative CSC-marker (ALDH1A1, CD44) expression was therefore evaluated by immunohistochemistry in a paraffin-embedded cohort of 57

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9

Choi, Mi-Yon. "P53 mediated cell motility in H1299 lung cancer cells." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/109.

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Studies have shown that gain-of- function mutant p53, AKT, and NFκB promote invasion and metastasis in tumor cells. Signals transduced by AKT and p53 are integrated via negative feedback between the two pathways. Tumor derived p53 was also indicated to induce NFκB gene expression. Due to the close relationship between p53/AKT and p53/NFκB, we hypothesized that AKT and NFκB can enhance motility in cells expressing mutant p53. Effects on cell motility were determined by scratch assays. CXCL5- chemokine is also known to induce cell motility. We hypothesized that enhanced cell motility by AKT and

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Kapeleris, Joanna C. "Circulating tumour cells in non-small cell lung cancer." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228607/1/Joanna_Kapeleris_Thesis.pdf.

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Circulating tumour cells (CTCs) have the potential to transform the management of patients with non-small cell lung cancer (NSCLC). The applications of CTCs can identify clinically actionable targets to predict treatment response and to better understand metastasis. CTCs isolated using microfluidics can be used as prognostic indicators of NSCLC as well as characterizing for markers of immunotherapy (PD-L1), molecular targets (ALK, EGFR). Short term cultures were successfully expanded in 9/70 NSCLC patients and cultured for up to 3 months. Optimization of this novel CTC culture model provides o

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11

Sherwood, Benedict T. "Radiosensitivity in bladder cancer cells." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29874.

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Potentially curative treatment options for patients with organ-confined transitional cell carcinoma (TCC) of the bladder (T1-4a/N0/M0) are radical cystectomy or radiotherapy (RT)-based 'bladder-preserving' regimens. A substantial number of patients who receive RT fail to respond (approximately 50%). Consequently, a greater understanding of the mechanisms of radioresistence is required, together with predictive information regarding the response of tumours to RT. Hypoxia and intrinsic cellular Radiosensitivity (IRS) are examined here, a factors that may influence the outcome of RT.;An immunohis

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12

Chan, Ching Wan. "Apoptosis in breast cancer cells." Thesis, University of Bristol, 2004. http://hdl.handle.net/1983/8971525c-0de9-4e21-9677-ab73d61ae65c.

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Dai, Prè Elena <1990&gt. "ELECTRICAL CHARACTERIZATION OF CANCER CELLS." Master's Degree Thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/6321.

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In this work, the impedance of different cancer cell lines was measured using a lab-on-chip device developed by imec (interuniversity electronics center) in Leuven, Belgium. The motivation of this thesis is the detection of circulating tumour cells (CTCs) from cancer metastatic patients. Currently CTC detection is challenging because of the low abundance and phenotype similarity with white blood cells. Imec is developing a proprietary transistor-embedded device for massively parallel on-chip single cell characterization in the European project MIRACLE (Magnetic Isolation and moleculaR Analysi

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14

Kadaba, Raghunandan. "Desmoplastic stromal cells modulate tumour cell behaviour in pancreatic cancer." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8825.

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Pancreatic ductal adenocarcinoma (PDAC) is characterised by an intense desmoplastic stromal response that can comprise 60 to 80% of tumour volume and has been implicated to be a factor in promoting tumour invasiveness and the poor prognosis associated with this cancer type. It is now well established that pancreatic stellate cells, which are vitamin A storing cells found in the periacinar spaces of the stroma in the normal gland, are primarily responsible for this desmoplastic reaction. Studying the interaction between stellate cells and cancer cells could provide for a better understanding of

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15

Wang, Wei. "Modulation of immune cell responses by small cell lung cancer cells." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/modulation-of-immune-cell-responses-by-small-cell-lung-cancer-cells(7bdc85c2-acd8-4f13-9d2b-e2ce07d1567b).html.

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Small Cell Lung Cancer (SCLC) accounts for 15-20% of all lung cancers and kills at least one person every 2 hours in the UK. There is no effective treatment and overall 2-year survival is less than 5%. Patients with SCLC have poorly understood local and systemic immune defects. Previous studies have shown several important defects in cell-mediated immune responses in patients with SCLC. A better understanding of interactions between SCLC tumour cells and immune cells may lead to the development of novel therapeutic approaches. There is increasing recognition that immunological biomarkers may a

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16

Grero, Dhanya. "Cytotoxicity of Vγ9Vδ2 T cells towards Colon Cancer Cells". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230976.

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Immunotherapies for cancer are widely studied at present. We are currently studying a specific form of “Vγ9Vδ2 T cells” found in the peripheral blood of healthy donors that can be used for the killing of HT-29 colon cancer cells. In order to determine the cytotoxicity of effectors, Vγ9Vδ2 T cells towards target cells, HT-29, it is important to first evaluate the absolute number of Vγ9Vδ2 T cells in a mixed cell population, and next to determine the phenotypic characterization, their activity and cytotoxicity in the presence of target cells. A flow cytometry and bead based assay was developed t

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Fung, Kwong-lam, and 馮廣林. "Chemoresistance induced by mesenchymal stromal cells on cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205639.

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Human mesenchymal stromal cells (hMSCs) are part of bone marrow micro-environment that supports hematopoiesis. However, hMSCs also enhance tumor progression and survival when they become part of the cancer micro-environment. I aimed to investigate the interaction between hMSCs and cancer cells during chemotherapy. Firstly, I studied the interaction between hMSCs and T-lineage acute lymphoblastic leukemia (T-ALL) cells under pegylated arginase I (BCT-100) treatment. Three T-ALL cell lines were sensitive to BCT-100 but not hMSCs. Conversely, hMSCs could partly protect all T-ALL cell lines fro

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18

Sterrenberg, Jason Neville. "Molecular chaperone expression and function in breast cancer and breast cancer stem cells." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1016238.

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The Cancer Stem Cell (CSC) theory suggests that cancers arise from and are maintained by a subpopulation of cancer cells with stem cell properties. Molecular chaperones are key components of cellular regulation. The overexpression of chaperones has become synonymous with cancer cells with chaperones being recognized as bona fide anti-cancer drug targets. Although chaperone activity has been characterized in cancer cells, very little is known about the cellular functions of chaperones in cancer stem cells. We set out to compare the expression of selected molecular chaperones in non-stem cancer

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19

Hosseini, Shirazi Seyed Farshad. "Cell cycle dependency of cisplatin cytotoxicity on ovarian cancer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/NQ36776.pdf.

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20

Qi, Yue. "Roles of ADAM12 in triple-negative breast cancer: regulation of cancer stem cells." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/35780.

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Doctor of Philosophy<br>Biochemistry and Molecular Biophysics Interdepartmental Program<br>Anna Zolkiewska<br>ADAM12 (A Disintegrin and Metalloprotease 12) is a cell surface protease, which is deregulated in many human diseases. High expression of ADAM12 in triple-negative breast cancers (lacking estrogen receptor, progesterone receptor, and HER2 expression) is associated with poor patient prognosis. My dissertation focused on the understanding of the biological functions of ADAM12 in triple-negative breast cancers. I found that ADAM12 is significantly upregulated in the claudin-low molecular

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21

Fancher, Karen. "Transcriptional Alterations during Mammary Tumor Progression in Mice and Humans." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/FancherK2008.pdf.

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22

Tang, Yuanyuan. "Nitric Oxide/Peroxynitrite Imbalance Induces Adhesion of Cancer Cells to Lymphatic Endothelium - Clinical Implications for Cancer Metastasis." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1439563414.

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23

Murray, Nicholas. "Costimulation of T cells and its role in T cell recognition of malignant colorectal cells in vitro." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301247.

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SCIANO', Fabio. "Development of natural and synthetic compounds as kinase inhibitors targeting cancer cells and cancer stem cells." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580156.

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25

Wright, Nicola. "Role of cancer stem cells in breast and prostate cancer." Thesis, Sheffield Hallam University, 2016. http://shura.shu.ac.uk/17363/.

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Cancer stem cells (CSC) are thought to be responsible for the initiation, propagation and tumour re-occurrence. CSC have been identified in most solid and haematological cancers and account for ~1% of the total cell population. Culturing cancer cell lines in monolayers enriches for the most dominant subpopulation which in most cases does not represent the slow dividing CSC population. We investigated the expression of CSC markers in 2D vs. 3D cell culture with the aim of identifying CSC-like cells via a nanog-reporter cell line and enable the subsequent targeting of these cells with CSC-target

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26

Gomes, Cátia Sofia Vicente. "Cues for cancer stem cells origin." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/12439.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Neural stem/progenitor cells (NSPC) can differentiate into neurons and glial cells in the central nervous system. Interestingly, NSPC biology is being applied to the study of human brain tumours, since these cells share some common features with glioma cells. However, it is not known the developmental stage with more similarities to glioma cells, or the most susceptible to malignant transformation. We aimed to identify the stage(s) in the NSPC differentiation process towards astrocytes where cells acquire phen

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Sehl, Mary Elizabeth. "Stochastic dynamics of cancer stem cells." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=2023755671&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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MesenhoÌˆller, Maike. "Endogenous photosensitisation of pancreatic cancer cells." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343044.

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Beatty, John David. "Characterisation of Bladder Cancer Dentritic Cells." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487987.

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Bacillus Calmette-Guerin (BCG) is the most effective intravesical therapy for superficial bladder cancer. It is hypothesised that BCG therapy has a local and systemic effect on antigen-presenting dendritic cells (DC) and that characteristics and variations in DC may reflect those of DC in cancer tissue. Blood, urine and tissue samples were taken from patients with bladder cancer before and during treatment with intravesical BCG. In blood the percentages and numbers of DC expressing maturation, co-stimulatory and intracellular cytokine markers were measured using flow cytometry. Immune response

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Nicholl, Amanda Jayne. "Volume regulation in human cancer cells." Thesis, University of Huddersfield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368311.

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Baenke, F. "Metabolic dependencies of breast cancer cells." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1387846/.

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Cellular metabolism is one of the core processes for cell growth and proliferation. This process is altered in cancer cells as most solid tumours exhibit increased glucose uptake and lactate secretion, a feature known as the Warburg effect. These metabolic changes are the consequence of oncogene activation, loss of tumour suppressor function and/or mutations in metabolic enzymes. However, cancer cell metabolism is not limited to the Warburg effect and the exact role the metabolic machinery plays in facilitating proliferation and cell survival in different cancer types is still poorly understoo

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32

Martinez, Rebecca L. "Chemosensory Evaluation of Prostate Cancer Cells." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/46316.

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Prostate cancer is the most commonly diagnosed disease and second most commonly caused death among men in America. Although much controversy surrounds the current methods of detection, PSA test and biopsy, no new methods have been approved as an effective method of detection. Biomarkers and non-invasive means of detection are being investigated everyday in hopes of discovering new information that could be of use in the prostate cancer field. One such non-invasive technology is the use of an electronic nose. The electronic nose technology has been utilized in the agricultural, food, biomedica

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Phillips, Tiffany Marie. "Breast cancer stem cells and radiation." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1383484841&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Hakulinen, Juha. "Complement-mediated killing of cancer cells." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/hakulinen/.

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Moore, Nathan F. "Slow-Cycling Cancer Cells: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/620.

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Tumor recurrence after chemotherapy is a major cause of patient morbidity and mortality. Recurrences are thought to be due to small subsets of stem-like cancer cells that are able to survive chemotherapy and drive tumor re-growth. A more complete understanding of stem-like cancer cell regulation is required to develop therapies to better target and eliminate these cells. Slow-cycling stem cells are integral components of adult epithelial tissues and may give rise to cancer stem cell populations that share similar characteristics. These slow-cycling adult stem cells are inherently resistant to

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Board, Mary. "A study of energy metabolism in neoplastic cells." Thesis, University of Oxford, 1990. http://ora.ox.ac.uk/objects/uuid:d3e13e31-3fe8-4cd8-ad71-50d4e7df4d27.

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Tian, Fei. "Effect of the Hedgehog Pathway inhibitor GDC-0449 in lung cancer cells and lung cancer stem cells." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-156374.

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The cancer stem cell hypothesis implicates that tumor cell population is heterogeneous with relatively well-differentiated cells and poorly-differentiated cells. Only the small population of tumourigenic poorly-differentiated CSCs can escape the normal limits of self-renewal and has the ability to proliferate and maintain the malignant growth of the tumor. One characteristic of stem cell is that the ability to exclude DNA dyes, such as Hoechst 33342 via the over-expression of ATP-binding cassette transporters (ABC transporters) on the cell membrane. It makes the detecting of the stem cell pos

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Ajabnoor, Ghada. "Mechanism of cell death in drug resistant human breast cancer cells." Thesis, University of Surrey, 2010. http://epubs.surrey.ac.uk/842867/.

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Anticancer drug resistance occurs as a result of altered response to cytotoxic insult, via inhibition or inactivation of apoptosis (programmed cell death type I, PCDI), which plays a major role in tumour development and progression. An alternative form of cell death - non-apoptotic, or autophagic cell death (PCD II) has recently emerged as a factor contributing to the cytotoxic response of cancer cells. We studied in vitro cell death in a drug resistant model MCF-7 human breast cancer cells with acquired resistance (c. 10- 20 fold) to paclitaxel, termed MCF-7TaxR. It has been reported that the

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Stordal, Britta Kristina. "Regrowth resistance in platinum-drug resistant small cell lung cancer cells." Bill Walsh Cancer Research Laboratories, Royal North Shore Hospital and The University of Sydney, 2007. http://hdl.handle.net/2123/2467.

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Doctor of Philosophy (PhD)<br>The H69CIS200 cisplatin-resistant and H69OX400 oxaliplatin-resistant cell lines developed as part of this study, are novel models of low-level platinum resistance. These resistant cell lines do not have common mechanisms of platinum resistance such as increased expression of glutathione or decreased platinum accumulation. Rather, these cell lines have alterations in their cell cycle allowing them to proliferate rapidly post drug treatment in a process known as ‘regrowth resistance’. This alteration in cell cycle control has come at the expense of DNA repair capaci

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Caldon, Catherine Elizabeth Garvan Institute of Medical Research Faculty of Medicine UNSW. "Cell cycle control by ID1 and WT1 in breast cancer cells." Awarded by:University of New South Wales. Garvan Institute of Medical Research, 2007. http://handle.unsw.edu.au/1959.4/33125.

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Loss of proliferative control is a cornerstone of cancer development, induced by deregulation of mitogenic signalling, insensitivity to anti-proliferative signals and direct changes in cell cycle proteins. In breast cancer these alterations are frequently targeted through cyclins D1 and E, leading to defects in G1/S transition. I have investigated the role of two potential pro-proliferative oncogenes in breast cancer, id1 andwt1. Each protein promotes proliferation in distinct contexts, with unique consquences for breast cancer cells. Using a 3D culture model of non-transformed mammary epithel

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Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.

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Breast carcinoma is the most commonly diagnosed cancer among women worldwide, with approximately 1 in 7 expected to be affected during her lifetime. The spread of breast cancer to secondary sites is generally incurable. Bone is the preferred site of metastasis, where the development of a secondary tumour causes severe osteolysis, hypercalcemia and a considerable pain burden. However, how breast cancer cells establish supportive interactions with bone cells is not well understood. We have examined the effects of factors released from MDA-MB-231 and 4T1 breast cancer cells on the differentiation

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Blakemore, Louise Margaret. "Curcumin-induced G2/M cell cycle arrest in colorectal cancer cells." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9809.

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Curcumin, a diet-derived chemopreventive and chemotherapeutic agent has been shown to induce G2/M cell cycle arrest, and previous studies suggested that microtubule depolymerisation may be linked to M-phase arrest. However, mechanisms involved have not been elucidated and often non-physiological concentrations of curcumin were used. The goal of this study was to characterise in more detail curcumin-induced cell cycle arrest using a panel of human colorectal cancer cell (CRC) lines, HT-29, SW480, HCT116 p53+/+, HCT116 p53-/- and HCT116 p21-/-. Using physiologically relevant concentrations of cu

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Stordal, Britta. "Regrowth resistance in platinum-drug resistant small cell lung cancer cells." Connect to full text, 2006. http://hdl.handle.net/2123/2467.

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Thesis (Ph. D.)--University of Sydney, 2007.<br>Title from title screen (viewed 10 June 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Medicine, Faculty of Medicine. Degree awarded 2007; thesis submitted 2006. Includes bibliographical references. Also available in print form.

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Wilkie, Alexander David. "Evasion of Cell Death in Burkitt’s Lymphoma and Pancreatic Cancer Cells." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367897.

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This thesis examined exploitation of cell death to combat cancer from two angles: investigating cell death signalling pathways to find new targets for treatment, and using the novel anti-austerity approach to combat the tolerance of cancer cells to nutrient deprivation. Cancers often display high levels of genetic diversity, even within cancers of a particular organ. These genetic differences often make treatments which work with a particular cancer ineffective on another - even from the same origin, and lead to differences in outcomes to selective pressures such as nutrient deprivation. Cur

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Mai, Thi Trang. "Cell death mechanisms of Marmycin A and Salinomycin in cancer cells." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS014.

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Le produit naturel salinomycine (SAL) est largement utilisé comme médicament anticoccidien et maintenant de plus en plus reconnu comme un agent destiné à réduire la proportion de population CD44⁺ / CD24⁻ cellules souches du cancer du sein. Ce facteur est important et intervient lors des rechutes des tumeurs du sein. Pour la première fois, nous avons décrit que l'action n’était pas ionophorique mais que le proton dit "éponge" de la salinomycine ciblait particulièrement la population des cellules souches du cancer. De plus, un analogue alcyne-amine synthétisé de la salinomycine a une action simi

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Adla, Shalini. "Characterization of the neural cell recognition molecule L1 in breast cancer cells and its role in breast cancer cell motility." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 125 p, 2008. http://proquest.umi.com/pqdweb?did=1459905751&sid=5&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Chen, Ting-Yeh, and 陳亭曄. "Isolation of colon cancer cells and cancer stem cells from primary colon cancer tissue for establishing patient-specific cancer cell lines." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7a63c6.

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碩士<br>國立中央大學<br>化學工程與材料工程學系<br>106<br>Tumors contain a small subpopulation of cells, i.e., cancer-initiating cells or cancer stem cells (CSCs), which exhibit stem cell properties, possess a self-renewing capacity and are responsible for tumor generation and metastasis. Cancer stem cells persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Furthermore, it is expected to establish primary colon cancer cell lines in vitro, since patient specific colon cancer cell lines is in great advantages of developing patient specific therapy in clinical ap

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Lee, Eric, and 李文淵. "The Evolvement of the Cell-Substrate Interaction over Time for Normal Cells and Cancer Cells and for Cancer Cells Treated with Anti-Cancer Medicine." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/38955474704779877017.

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碩士<br>國立暨南國際大學<br>生物醫學科技研究所<br>98<br>In this paper, we discussed the cell-substrate interaction by adding several kinds of stimulus to cancer cells and normal cells. In the work, we seeded the living cells onto the silicon wafer surface that was modified with 3- aminopropyltriethoxysilane (γ-APTES)for different periods of time, then removed the cells from the chip and, measured the surface morphology profiles of the γ-APTES layer by atomic force microscopy (AFM) to realize the possible cell-substrate interactions between the cell and the substrate beneath, and to observe the evolvement of cell

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Tseng, Ju-Yu, and 曾如玉. "Role of cancer stem cells in colorectal cancers." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/12021328237607934533.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>96<br>Colorectal cancer is third common cause of cancer-related death, indicating that some of its cancer cells are not eradicated by current therapies. Recent observations indicate that, in several types of human cancer, only a phenotypic subset of cancer cells within each tumor is capable of initiating tumor growth. This functional subset of cancer cells is operationally defined as the ‘‘cancer stem cell’’ (CSC) subset. There are two strategies to identify CSCs. Side population (SP) cells have been isolated from several solid tumors, and CRC-CSCs also have a put

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Chon, Ka-Hou, and 秦嘉豪. "Dermatopontin Modulates Cell Cycle Progression of Cancer cells." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/77187877083123301322.

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碩士<br>國立陽明大學<br>醫學生物技術研究所<br>94<br>The human dermatopontin (DPT), a component of the extracellular matrix, interacts with TGFβ and decorin. The decorin has been shown to suppress the transformation phenotype of colon carcinoma cells. Interestingly, DPT protein sequence is 92% homolog to EQ-1, an early quiescence-1 murine gene, which is induced shortly after serum deprivation in BALB/c 3T3 cells and its RNA is markedly expressed in heart and lung (1). To test whether DPT is also related to cell quiescence, we have examined its expression in serum-deprived condition in RKO and SKOV3-ip1 cancer c

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