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Rozprawy doktorskie na temat „Cancer neuroendocrine”

Autor: Grafiati

Data publikacji: 11 stycznia 2025

Data aktualizacji: 31 lipca 2025

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1

Vias, Maria. "Neuroendocrine differentiation in hormone resistant prostate cancer cells." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612330.

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2

Hanna, Fahmy William Fahmy. "Calcitonin and related peptides in mammalian neuroendocrine tumours." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295357.

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3

Bryant, Jennifer. "Neuroendocrine and epithelial markers of small cell lung cancer." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/neuroendocrine-and-epithelial-markers-of-small-cell-lung-cancer(c7c51e2c-6443-4021-b2ff-469966cd10b6).html.

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Small cell lung cancer (SCLC) is an extremely aggressive disease characterized by early metastasis and acquired resistance to therapy. SCLC is distinguished by its neuroendocrine (NE) component; the role of which is not fully understood in metastasis and response to therapy. Patients respond exceptionally well to first round chemotherapy; however, relapse with therapy-resistant tumours is virtually inevitable. Hypoxic regions within tumours can contribute towards metastasis and therapy resistance, highlighting hypoxia-targeted therapy as a novel approach for improving treatment for SCLC patien

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4

Poiraudeau, Loïc. "Identification de nouvelles cibles thérapeutiques dans le cancer neuroendocrine de la prostate." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL143.

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Le cancer de la prostate est le cancer le plus fréquent chez l'homme et il constitue la deuxième cause de mortalité par cancer chez l'homme dans les pays industrialisés. Le traitement systémique de ces cancers repose sur une déprivation androgénique par castration chirurgicale ou pharmacologique. Le cancer de la prostate métastatique résistant à la castration (mCRPC) est traité par des inhibiteurs de la voie des androgènes (ARPI). Cependant, environ un tiers des patients ne sont pas sensibles à ces médicaments et les autres, sensibles initialement, développent malheureusement une résistance se

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5

Гирявенко, Наталія Іванівна, Наталья Ивановна Гирявенко, Nataliia Ivanivna Hyriavenko, et al. "Synchronous case of the primary neuroendocrine cancer of fallopian tube and serous papillary cancer of ovary." Thesis, Springer, 2019. http://essuir.sumdu.edu.ua/handle/123456789/75206.

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Neuroendocrine tumours commonly occur in the gastrointestinal tract and lungs. They rarely were found in the genital organs. There are a few data about this neoplasia in the fallopian tubes, which is accidentally identified during the morphological study. The aim of our investigation was to demonstrate the case of the primary neuroendocrine cancer of the fallopian tube in combination with the serous papillary cancer of the ovary.

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Balabanova, Silviya. "The neuroendocrine-like phenotype of gastric myofibroblasts and its significance in cancer." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/6453/.

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Cell-cell communication, and specifically epithelial-mesenchymal signalling, is a key factor determining normal tissue development and organisation in hollow organs such as gastrointestinal tract. Mechanisms governing normal epithelial-mesenchymal communication have been studied for many years, but the changes occurring during tissue damage, infection and inflammation, and in cancer, remain unclear. Myofibroblasts are recognised as key mesenchymal cells involved in this communication in health and in disease. Myofibroblasts produce and secrete many proteins responsible for the assembly of extr

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7

Bari, Muhammad Furqan. "Biomarkers for the classification of high grade neuroendocrine lung cancers." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56420/.

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In the management of lung cancer the most important step beyond establishing the presence a malignant tumour is identifying whether the tumour is small cell lung cancer (SCLC) or one of the variants of non-small cell carcinoma (NSCLC), which includes adenocarcinoma (AD), squamous (SCC), large cell carcinoma (LCC), large cell neuroendocrine carcinoma (LCNEC), typical carcinoids (TC) and atypical carcinoids (AT). SCLC is a high grade neuroendocrine tumour which usually presents as central mass. These tumours are not usually amenable to curative surgical resection and are treated primarily by che

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8

McWhinney, Sarah Renee. "Role of tumor suppressor genes in neuroendocrine neoplasias and cardiovascular disease." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1133373765.

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9

Goodin, Jeremy Lee. "Characterization of Gene Expression During Adenosine 3':5'-Cyclic Monophosphate Induced Neuroendocrine Differentiation in Human Prostatic Adenocarcinoma." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/26791.

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The LNCaP cell line is a versatile and useful model that is suitable for the study of human prostate cancer in vitro. The elevation of LNCaP intracellular cAMP levels through the addition of membrane permeable cAMP analogues, phosphodiesterase inhibitors, adenylate cyclase activators, or components of the cAMP signal transduction pathway can induce reversible neuroendocrine differentiation. Elucidation of those genes that are differentially expressed between undifferentiated prostate cancer cells and prostate cancer cells that have been induced to differentiate may present new insights for t

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10

Chen, Ruiqi. "Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine prostate cancer." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62099.

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Treatment-induced neuroendocrine (NE) prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer (PCa) that can arise as a consequence of rigorous androgen receptor pathway inhibition (ARPI) therapies now used to treat castration resistant disease (CRPC). While the PI3K/AKT pathway has been investigated as a co-therapeutic target with ARPI for advanced prostate adenocarcinoma, whether this strategy has implications on t-NEPC progression remains unknown. Findings from this work indicate that PI3K/AKT inhibition alone reduces protein expression of the RE-1 silencing transcription fact

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11

Yeung, Jake. "Identification of RNA binding proteins associated with differential splicing in neuroendocrine prostate cancer." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46688.

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Alternative splicing is a tightly regulated process that can be disrupted in cancer. Established cancer genes express splice isoforms with distinct properties and their differential expression is associated with tumour progression. Although prostate adenocarcinoma (PCa) is effectively managed at early stage by therapies targeting the androgen receptor signaling axis, up to 30% of late stage prostate cancers progress to a treatment-resistant form of the disease called neuroendocrine prostate cancer (NEPC), for which there are few therapeutic options. It is histologically dis

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12

Ocejo-Garcia, Marta. "Is the neuroendocrine phenotype an early marker in the development of lung cancer?" Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272381.

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13

Leblay, Noémie. "Molecular characterization of rare thoraco-abdominal tumours." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1351.

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Les carcinoïdes pulmonaires, les carcinomes neuroendocriniens à grandes cellules (LCNEC) et les mésothéliomes malins sont des tumeurs thoraciques rares, dont l'incidence a augmenté au cours des dernières années. Le diagnostic de ces tumeurs est soumis à la variabilité inter-observateur et les opportunités thérapeutiques sont limitées. De grandes études génomiques visant à les caractériser au niveau moléculaire pourraient aider à mieux comprendre les mécanismes sous-jacents à leur développement et faciliter le diagnostic et le traitement de ces maladies. Mon projet de thèse visait à combler les

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14

Grönberg, Malin. "Expression of Neuroendocrine Markers in Normal and Neoplastic Tissue with an Emphasis on Ghrelin and Obestatin." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130972.

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The aim of this thesis was to characterize the expression of the peptides ghrelin and obestatin, as well as other neuroendocrine markers in human normal tissues, in invasive breast cancer and a wide panel of neuroendocrine tumors (NETs). In normal tissues the expression of ghrelin and obestatin was mainly localized to the gastric mucosa, and in lesser extent in the remaining gastrointestinal tract, endocrine pancreas and mammary glands. Double immunofluorescence studies demonstrated that ghrelin and obestatin were co-localized in the same cells displaying the same cytoplasmic distribution. In

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15

Barazeghi, Elham. "Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors." Doctoral thesis, Uppsala universitet, Endokrinkirurgi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330810.

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Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). In Paper I, an undetectable/very low level of 5hmC in parathyroid carcinomas (PCs) compared to parathyroid adenomas with positive staining, suggested that 5hmC may represent a novel biomarker for parathyroid malignancy. Immunohistochemistry revealed that increased tumor weight in

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16

Senden, Nicole Hubertina Maria. "NSP-reticulons characterization and use for the detection of neuroendocrine differentiation in lung cancer /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=8353.

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17

Yan, Ge [Verfasser]. "Therapeutic value of artesunate in neuroendocrine cancer treatment inspired by EGFR expression / Ge Yan." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1191197670/34.

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18

Hirth, Carlos Gustavo. "The prognostic value of neuroendocrine differentiation and stem cells markers for localized prostate cancer." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18238.

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This study aimed to evaluate the new immunohistochemical markers related to neuroendocrine differentiation induction and stem cells with prognostic factors and biochemical recurrence in patients submitted to radical prostatectomy. Therefore, patients operated at the Hospital Walter CantÃdio, Federal University of CearÃ, in the period of 2008-2013, underwent clinical and outpatient follow-up, between the years 2008-2016. Biochemical recurrence was evaluated and was correlated with pathological characteristics and immunohistochemical reactions. Chromogranin (neuroendocrine differentiation), Auro

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19

Guo, Yingbo. "Rôle du cil primaire au cours de la transdifferentiation neuroendocrine du cancer de la prostate." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6005.

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Le cancer de la prostate est l’un des cancers malins les plus répandus dans le monde, avec 95 % des patients diagnostiqués présentant un adénocarcinome de la prostate sans marqueurs neuroendocriniens. Le cancer neuroendocrinien de la prostate de novo représente un sous-type rare et agressif. Environ 20 % des cas d’adénocarcinome de la prostate évoluent vers le cancer neuroendocrinien de la prostate après un traitement de privation androgénique. Le traitement de privation androgénique bien qu’efficace, peut également induire une différenciation neuroendocrinienne de l'adénocarcinome de la prost

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20

Bayourthe, Pierre. "Les carcinomes neuro-endocrines cutanés ou tumeurs à cellules de Merkel : à propos d'une observation." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2M170.

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21

Fuentes, Jean. "Carcinome neuro-endocrine bronchique et calcitonine : à propos d'un cas." Montpellier 1, 1990. http://www.theses.fr/1990MON11259.

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22

Pobel, Cédric. "Characterization of de novo metastatic prostate cancer : an ancillary study of the PEACE-1 phase 3 clinical trial." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL118.

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Le cancer de la prostate de novo métastatique sensible à la castration représente 5 à 10% des cancers de la prostate au diagnostic mais est responsable de 50% des décès lié aux cancers de la prostate tous stades confondus. Dans cette étude ancillaire de l'essai PEACE-1, notre hypothèse était que les variants agressifs ou neuroendocrine peuvent être détectés dès le diagnostic. Nous avons rapatrié de façon centralisée les prélèvements en paraffine des biopsies au diagnostic des patients inclus dans PEACE1 (NCT01957436) pour réaliser des analyses d'immunohistochimie (IHC), de séquençage de nouvel

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23

Nip, Ka Mun. "TNIK, a novel androgen receptor-repressed gene, is a potential biomarker for neuroendocrine prostate cancer." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/64148.

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Traf2- and Nck-interacting kinase (TNIK) is a serine/threonine kinase upregulated and amplified in pancreatic and gastric cancer respectively. TNIK has also been identified as a potential therapeutic target of colorectal cancer. However, the role of TNIK in prostate cancer (PCa) has not been investigated. Interrogating public human PCa patient data, we found that TNIK expression is associated with an aggressive form of PCa termed neuroendocrine prostate cancer (NEPC). Treatment-induced NEPC can arise as a consequence of strong selective pressure from androgen receptor (AR) pathway inhibition.

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24

Sandoval, Díaz Ither, Alarcón Ronald Hernández, Cuervo Fernando Palacios, et al. "Tumor neuroendocrino en cérvix uterino: reporte de caso." Sociedad Chilena de Obstetricia y Ginecología, 2015. http://hdl.handle.net/10757/550713.

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Neuroendocrine tumors of the cervix are extremely rare. Women diagnosed with small cell neuroendocrine carcinoma of the cervix have a higher frequency of metastases in the lymph nodes, lymphovascular invasion, recurrence and worse prognosis compared to those with other types of cervical neoplasia. We report the case of a 58-year-old female, with a history of six years of postmenopausal irregular vaginal bleeding, in addition to symptoms related to chronic anemia. Gynecological examination showed a tumor of 4 cm that occupied the upper third of the vagina and protruded through the cervix initia

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25

Blanc, Charly. "La Neuropiline-1, un nouveau biomarqueur de résistance thérapeutique du cancer de la prostate." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0072.

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Le cancer de la prostate représente actuellement un problème majeur de santé publique. L’hormonothérapie, par privation de l’axe androgénique, constitue aujourd’hui la seule arme thérapeutique efficace pour les formes avancées. Malgré un taux important de réponse initiale, une forme de résistance survient inéluctablement, conduisant pour la plupart au décès du patient. La progression tumorale vers la résistance à la castration est un processus multifactoriel. Elle peut être associée à une dérégulation de l’axe du récepteur des androgènes, l’activation de voies de survie cellulaire, et favorise

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26

Larsson, Dhana E. "Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158833.

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Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. The aim of the thesis was to find new compounds active against neuroendocrine tumors (NETs). In paper I, we screened 1280 substances on two bronchial carcinoid cell lines and one pancreatic carcinoid cell line. Eleven of these compounds were found to have antitumor ac

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Erramouspe, Pasilio Pablo Joaquin. "The Facilitates Chromatin Transcription (FACT) complex as a novel target for the treatment of Neuroendocrine Prostate Cancer." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/229973/1/Pablo%20Joaquin_Erramouspe%20Pasilio_Thesis.pdf.

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This thesis is about the role of The Facilitates Chromatin Transcription (FACT) complex as a potential target for Neuroendocrine Prostate Cancer (NEPC). I studied FACT complex in different models representing the main stages of prostate cancer progression and found that FACT complex expression correlated to the lethal NEPC phenotype. The FACT-inhibiting drug, CBL1037, was more effective at reducing cell viability as compared to the standard-of-care chemotherapy drugs, cisplatin and carboplatin. Significantly lower dose of CBL0137 was required to achieve 50% cell death. These results are promis

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Rossi, Gina. "Regulation of the physiological consequences of neuroendocrine differentiation in prostate cancer by kinase and phosphatase cross talk." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34186.

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Prostate cancer is a leading health concern among Canadian males, with one in seven Canadian men developing the disease in their lifetime and one in 27 dying from it. Localized prostatic disease can be treated with surgery, but once metastasis occurs, clinicians rely on the hormone dependent nature of the tumor for treatment. Androgen withdrawal therapy is very effective at limiting tumor growth; however, progression of the tumor to an androgen independent state is inevitable, and at the present time there is no effective therapy for this form of the disease. Neuroendocrine (NE) cells are

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Wang, Da-Gong. "Expression of oncogenes and a breast cancer associated protein, pS2, in human neuroendocrine tumours : implication for tumourigenesis." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361236.

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Soori, Mehrnoosh. "Neuroendocrine differentiation of prostate cancer cells a survival mechanism during early stages of metastatic colonization of bone /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 105 p, 2009. http://proquest.umi.com/pqdweb?did=1654490661&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Capodanno, Ylenia. "Identifying therapeutic implications of cancer stem cells in human and canine insulinoma." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31175.

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Pancreatic neuroendocrine tumours (PNETs) are the most common neuroendocrine tumours diagnosed in humans and dogs. Due to the highly heterogeneous nature of these tumours, definitive data are still lacking over the molecular mechanisms involved in their cancerous behaviour. This study focused on insulinoma (INS), as it is the most commonly diagnosed PNET in human and veterinary oncology. INS is an insulin-producing tumour that causes a hypoglycaemic syndrome related to the excessive insulin production. In humans, it is often a small benign neoplasm readily curable by surgical resection whereas

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32

Yu, Di. "Adenovirus for Cancer Therapy : With a Focus on its Surface Modification." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203662.

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Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surface of tumor cells. We engineered Ad5 virus with the protein transduction domain (PTD) from the HIV-1 Tat protein (Tat-PTD) inserted in the hypervariable region 5 (HVR5) of the hexon protein in the virus capsid. Tat-PTD-modified Ad5 shows a dramatically increased transduction level of CAR-negative cells and bypassed fiber-mediated transduction. It also overcomes the fiber-masking problem,

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33

Berenguer, Caroline. "Rôle de l'adrénomédulline dans le cancer de la prostate : implication dans la différenciation neuroendocrine et dans la progression tumorale." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20691.

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Les cancers prostatiques (CaP) sont des pathologies des plus fréquentes et représentent donc un problème de santé publique. Ils constituent actuellement un enjeu thérapeutique puisque 25% des patients traités par hormonothérapie sont victimes à plus ou moins longue échéance d’une baisse de l’efficacité du traitement : « échappement hormonal ou androgéno-indépendance ». Une meilleure compréhension des mécanismes impliqués dans ce phénomène est donc indispensable. Plusieurs études suggèrent un rôle des cellules neuroendocrines dans l’émergence de l’hormonoindépendance des CaP. Ces cellules neuro

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34

Dannoon, Shorouk Lewis Michael R. Jurisson Silvia. "Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/7019.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 25, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Silvia Jurisson and Dr. Mike Lewis. Vita. Includes bibliographical references.

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Franceschini, Gian Marco. "The DNA methylation landscape of metastatic prostate cancer: from characterization to liquid biopsy applications." Doctoral thesis, Università degli studi di Trento, 2023. https://hdl.handle.net/11572/364210.

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Epigenetic alterations are observed in virtually all cancer types, yet there is limited understanding of their role in tumorigenesis and evolution. The role of DNA methylation has been particularly elusive in this context. While this epigenetic mark has been extensively profiled in healthy and cancerous samples, our ability to understand its relationship with underlying biological processes is still limited. Moreover, recent advancements in the profiling of cell-free DNA in circulation have sparked renowned attention toward tissue-specific and cancer-specific DNA methylation patterns. In this

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36

Maina, Peterson Kariuki. "Novel oncogenic roles and regulations of histone demethylase PHF8 in prostate cancer." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5562.

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Prostate cancer (PCa) is the most common cancer in American men. Although initial androgen deprivation therapy (ADT) confers a five year survival rate of 99%, the relapse of metastatic and drug resistant PCa (CRPC- Castration-Resistant PCa) continues to account for most deaths. How certain PCa cells develop into CRPC is the key question in the field. In addressing it, attention has focused on epigenetic factors that contribute to CRPC development. Herein we investigated the role and regulation of histone demethylase PHF8 during PCa neuroendocrine differentiation (NED) and progression into CRPC

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37

Gauerke, Jennifer Leigh. "Genetic Evaluation of Patients and Families with Concern for Hereditary Tumor Syndromes within the OSU James Multidisciplinary Neuroendocrine/Thyroid Cancer." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555086532080802.

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Zuazo, Gaztelu Iratxe. "Dual effect of Semaphorin 4D blockade in neuroendocrine tumor malignization: from vessels to macrophages." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664077.

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Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its therapeutic targeting remains a valid stroma-directed strategy in the fight against cancer. However, standard antiangiogenics fail to produce enduring beneficial effects due to the appearance of resistance, often as a consequence of intratumor hypoxia triggered by vessel trimming. In the case of neuroendocrine tumors (NETs), which are characterized by their low aggressiveness, high heterogeneity a

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39

Vanoverberghe, Karine. "Étude de l'altération de l'homéostasie calcique dans l'arrêt de croissance et la différenciation neuroendocrine des cellules cancéreuses prostatiques humaines." Lille 1, 2003. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2003/50376-2003-49.pdf.

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Le cancer prostatique évolue vers un stade androgéno-indépendant où aucun traitement hormonal ne peut provoquer un arrêt de la croissance cellulaire. Ce stade de la maladie est également caractérisé par la présence de cellules cancéreuses neuroendocrines, résistantes à l'apoptose. Le calcium joue un rôle primordial dans le contrôle de la croissance cellulaire. Aucune caractérisation des mécanismes calciques responsables d'un arrêt de croissance des cellules prostatiques cancéreuses androgéno-indépendantes et de la différentiation neuroendocrine, n'a été préalablement publié. Notre objectif fut

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40

Bery, Fanny. "Rôle de la signalisation calcique et de la transition épithélio-mésenchymateuse dans l’agressivité et la différenciation neuroendocrine du cancer de la prostate." Electronic Thesis or Diss., Tours, 2021. http://www.theses.fr/2021TOUR5010.

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La transition épithélio-mésenchymateuse (TEM) participe à l’agressivité du cancer de la prostate (CaP). Nous avons identifié une nouvelle voie de signalisation impliquée dans la progression tumorale et initiée par le TGFβ et l’hypoxie, deux inducteurs de la TEM. Il existe une boucle calcium dépendante entre Zeb1, facteur clé de la TEM, et le canal SK3, pouvant être inhibée par l’acide linoléique et l’acide eicosapentaénoïque, acides gras inversement corrélés à l’agressivité du CaP. Les thérapies ciblant le récepteur aux androgènes peuvent induire des réponses adaptatives telles que la TEM et l

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Cyrta, Joanna. "A Pleiotropic Role of the SWI/SNF Complex in Cancer – Insights From Two Tumor Types : Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Prostatic Carcinoma Role of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL045.

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Le complexe de remodelage de la chromatine SWI/SNF est un régulateur épigénétique majeur impliqué dans le développement embryonnaire et dans la différentiation cellulaire. De plus, les gènes qui encodent les sous-unités de SWI/SNF sont altérés dans au moins 20% de cancers. Bien que le complexe SWI/SNF soit le plus souvent considéré comme suppresseur des tumeurs, il existe des preuves croissantes que le rôle de SWI/SNF dans le cancer peut dépendre du type de tissu et du contexte.Dans la première partie de cette dissertation, nous présentons la caractérisation moléculaire d’une cohorte indépenda

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Rainey, Amanda Nichole. "Anatomical Analysis of Tachykinin-Related Peptide Distribution in the Thoracic Ganglion of the Crab, Cancer borealis." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564242169221564.

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Turpin, Anthony. "Étude des gènes réprimés par le récepteur aux androgènes dans les cancers de la prostate résistants à la castration et leur évolution neuroendocrine." Thesis, Lille, 2021. http://www.theses.fr/2021LILUS012.

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Dans le cancer de la prostate, la présence de gènes de fusion, issus de remaniementschromosomiques TMPRSS2:ERG dans plus de 50% des cas, aboutit à une dérégulation dutranscriptome prostatique. Le récepteur aux androgènes (AR), membre de la famille desrécepteurs nucléaires, reste toutefois l’acteur majeur de l’évolution du cancer de la prostate.Notre objectif est d’identifier des gènes pouvant avoir un rôle dans l’évolution du cancerde la prostate, en lien avec la fusion TMPRSS2:ERG et AR.Par une analyse transcriptomique, à partir d’un modèle de surexpression de la fusionTMPRSS2:ERG dans une li

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Hutchinson, Alexander B. "Identification of response pathways of prostate cancer cell lines in Hans Clevers Media." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/103982/4/Alexander%2520Blaine_Hutchinson_Thesis.pdf.

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Prostate cancer has been extremely difficult to grow in vitro, however recent development of a novel media has improved success rates of propagating tumour cells in the laboratory. This project aimed to define pathways regulated by this media in different prostate cancer cells in order to identify critical factors needed for prostate cancer survival. Both common and cell line-specific responses to the media were identified, demonstrating that not all prostate cancer cells respond the same way or have the same requirements. These unique responses must be considered when cells grown in this medi

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Ferguson, Mary L. "Angiogenesis in human lung tumours." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:865de25c-1ac3-4a30-85fa-a9fc677bfcc2.

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Angiogenesis, the growth of new blood vessels, is vital to tumour growth. Prevailing dogma has been that tumours cannot grow without angiogenesis. Based on this premise, anti-angiogenic drugs are used clinically. However, the principle of angiogenesis as an absolute requirement for tumour growth has been challenged with reports that many tumours are entirely or partially non-angiogenic. This study describes and quantifies characteristics of non-angiogenic non-small cell lung tumours, demonstrates non-angiogenic growth in small-cell/neuroendocrine lung tumours and investigates the underlying pa

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Lallet-Daher, Hélène. "Implication du canal potassique calcium dépendant à conductance intermédiaire IKca1 dans la cancerogenèse humaine." Thesis, Lille 1, 2008. http://www.theses.fr/2008LIL10135/document.

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Des études récentes montrent que l'homéostasie calcique intracellulaire, ainsi que l'expression et l'activité de canaux ioniques jouent un rôle essentiel dans le contrôle de la prolifération cellulaire aussi bien dans un contexte physiologique que dans certains cancers. Cependant, aucune approche proposant les canaux ioniques comme cible thérapeutique n'est actuellement envisagée dans le cadre des traitements des cancers de la prostate. Dans ce travail nous avons mis en évidence l'expression, la fonctionnalité et l'implication des canaux potassiques calcium-activés (IKca1) dans la prolifératio

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Dayon, Audrey. "Rôle de la sphingosine kinase-1 dans la survie et la progression des cellules tumorales prostatiques LNCaP vers l'androgéno-indépendance." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/307/.

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Le traitement du cancer de la prostate est basé sur la privation androgénique dont l'efficacité n'est que temporaire jusqu'à l'acquisition de l'androgéno-indépendace tumorale. Notre équipe a montré que l'oncogène sphingosine kinase (SK) est surexprimé dans le tissu tumoral prostatique, et que son activité enzymatique augmente avec l'agressivité tumorale. Nous avons exploré le rôle potentiel de la SK dans la survie et la progression des cellules tumorales prostatiques LNCaP vers l'androgéno-indépendance. Premièrement, nous montrons in vitro et in vivo que la privation androgénique entraîne une

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Subnis, Utkarsh B. "Stress management for cancer survivors using a technologically adapted psychosocial intervention: A randomized trial determining the effect of expressive writing on psychoneuroimmunology based outcomes." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3596.

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Patients with cancer transitioning from completing their final cancer treatments to survivorship are particularly at risk for experiencing psychosocial stress, and the Institute of Medicine (IOM) has referred to these cancer patients as “lost in transition.” In this study, patients with cancer in their transition phase after completing their final radiation treatment were defined as cancer survivors (CS). CS must deal with chronic stressors such as the fear of cancer recurrence as well as the resumption of their roles in their family and work lives. Chronic stress impacts the nervous system an

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Boichard, Amélie. "Caractérisation moléculaire des formes métastatiques de carcinome médullaire de la thyroïde." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T015/document.

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Le carcinome médullaire de la thyroïde (CMT) est une tumeur neuroendocrine rare, se développant à partir des cellules sécrétant la calcitonine. Cette tumeur survient dans un contexte familial dans un tiers des cas. Toutes les formes germinales et près de 40% des formes sporadiques sont causées par une mutation ponctuelle activatrice de l’oncogène RET, codant pour un récepteur membranaire à activité tyrosine kinase. Les événements oncogéniques à l’origine des formes sporadiques non mutées RET restent mal définis, à l’exception de mutations activatrices des oncogènes RAS découvertes récemment.Le

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Lallet-Daher, Hélène. "Implication du canal potassique calcium dépendant à conductance intermédiaire IKca1 dans la cancerogenèse humaine." Electronic Thesis or Diss., Lille 1, 2008. http://www.theses.fr/2008LIL10135.

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Des études récentes montrent que l'homéostasie calcique intracellulaire, ainsi que l'expression et l'activité de canaux ioniques jouent un rôle essentiel dans le contrôle de la prolifération cellulaire aussi bien dans un contexte physiologique que dans certains cancers. Cependant, aucune approche proposant les canaux ioniques comme cible thérapeutique n'est actuellement envisagée dans le cadre des traitements des cancers de la prostate. Dans ce travail nous avons mis en évidence l'expression, la fonctionnalité et l'implication des canaux potassiques calcium-activés (IKca1) dans la prolifératio

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