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1

Verma, Akash, Rucha S. Dagaonkar, Dominic Marshall, John Abisheganaden, and R. W. Light. "Differentiating Malignant from Tubercular Pleural Effusion by Cancer Ratio Plus (Cancer Ratio: Pleural Lymphocyte Count)." Canadian Respiratory Journal 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7348239.

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Background. We performed prospective validation of the cancer ratio (serum LDH : pleural ADA ratio), previously reported as predictive of malignant effusion retrospectively, and assessed the effect of combining it with “pleural lymphocyte count” in diagnosing malignant pleural effusion (MPE).Methods. Prospective cohort study of patients hospitalized with lymphocyte predominant exudative pleural effusion in 2015.Results. 118 patients, 84 (71.2%) having MPE and 34 (28.8%) having tuberculous pleural effusion (TPE), were analysed. In multivariate logistic regression analysis, cancer ratio, serum L
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International, Journal of Medical Science and Innovative Research (IJMSIR). "A Cross Sectional Study to Determine The Efficacy of Serum LDH: Pleural Fluid Ada Ratio As A Biomarker of Malignant Pleural Effusion in IRD, SMS Medical College, Jaipur." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 4 (2024): 151–58. https://doi.org/10.5281/zenodo.15422923.

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<strong>Abstract</strong> <strong>Introduction</strong>: The malignant pleural effusion is one of the most common causes of exudative pleural effusion. There is no accurate and commonly accepted biochemical marker of MPE, hence using common parameters two ratio serum LDH: pleural fluid ADA (cancer ratio) and cancer ratio: pleural fluid lymphocyte count (cancer ratio plus) derived and their efficacy in identification of MPE is studied. <strong>Methods</strong>: 60 undiagnosed pleural effusion patients were studied in a hospital based cross sectional observational analytical study. The values of
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Popowicz, Natalia, Hui Min Cheah, Cynthia Gregory, et al. "Neutrophil-to-lymphocyte ratio in malignant pleural fluid: Prognostic significance." PLOS ONE 16, no. 4 (2021): e0250628. http://dx.doi.org/10.1371/journal.pone.0250628.

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Predicting survival of patients with malignant pleural effusions (MPEs) is notoriously difficult. A robust prognostic marker can guide clinical decision making. The neutrophil-to-lymphocyte ratio (NLR) in blood has been shown to predict survival in many cancers. Pleural fluid bathes the malignant pleural tissues, thus the NLR of the pleural fluid may reflect more closely the local tumour environment. The objective of this study was to explore the prognostic significance of pleural effusion NLR for MPE. We analysed matched effusion and blood from 117 patients with malignant and 24 with benign p
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Singgih, Venny, Ketut Suryana, Ida Ayu Jasminarti Dwi Kusumawardani, Ni Wayan Candrawati, I. Gede Ketut Sajinadiyasa, and Ida Bagus Ngurah Rai. "Role of pleural fluid interleukin-6, neutrophil-lymphocyte ratio, and monocyte-lymphocyte ratio in distinguishing tuberculous and malignant pleural effusions." International Journal of Advances in Medicine 8, no. 4 (2021): 492. http://dx.doi.org/10.18203/2349-3933.ijam20211046.

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Background: Pleural effusion is caused by various disease, including tuberculosis infection and malignancy. To determine the etiology, immunologic parameters are needed to distinguish tuberculous and malignant pleural effusions, including pleural fluid interleukin-6 (IL-6), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR).Methods: This was a cross-sectional study, conducted at Sanglah General Hospital in Denpasar from March 2020 to September 2020. Pleural fluid IL-6 and leucocyte differential count were measured from subjects with tuberculous and malignant pleural effusio
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Chalamalasetty, Sai Pooja, Preetam Acharya, Thomas Antony, Anand Ramakrishna, and Himani Kotian. "The Use of “Cancer Ratio” in Differentiating Malignant and Tuberculous Pleural Effusions: Protocol for a Prospective Observational Study." JMIR Research Protocols 13 (December 23, 2024): e56592. https://doi.org/10.2196/56592.

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Background Differentiating between tuberculosis and malignancy as the cause of an exudative lymphocyte predominant pleural effusion is difficult due to similarities in the cellular and biochemical characteristics of the pleural fluid in both conditions. Microbiological tests in tubercular pleural effusions have a poor diagnostic yield, and the long turnaround time for results prevents an early diagnosis. The diagnosis of malignant pleural effusion (MPE) is hampered by a variable yield of pleural fluid cytology and closed pleural biopsy and the fact that thoracoscopy may not be readily availabl
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Ganesan, Natesh, Prasanth Gururaj, and Gangadharan Vadivelu. "Cholesterol pleurisy: a rare complication of tuberculosis." International Journal of Research in Medical Sciences 10, no. 11 (2022): 2689. http://dx.doi.org/10.18203/2320-6012.ijrms20222884.

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Pseudochylothorax (PCT) is a rare form of pleural effusion and is characterized by high cholesterol content and milky pleural fluid. Common causes include tuberculosis, rheumatoid arthritis, paragonimiasis, echinococcosis and neoplasia. A 27-year-old male presented with breathlessness for past 3 years aggravated for past 2 months, swelling in perianal region for 6 months with history of treatment for pulmonary tuberculosis with recurrent left pleural effusion for which intercostal drain (ICD) was inserted. Blood investigations showed elevated total leukocyte count and ESR. Radiological investi
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Gayaf, Mine, and Mustafa Canbaz. "Diagnostic Value of Cancer Ratio Plus Obtained by Dividing Cancer Ratio to Pleural Fluid Lymphocyte in Differentiation Malign Pleural Effusion from Tubercular Pleural Effusion." Turkish Thoracic Journal 20, no. -1 (2019): 6. http://dx.doi.org/10.5152/turkthoracj.2019.06.

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Iser, Stephanie, Sarah Hintermair, Alexander Varga, et al. "Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma." Cancers 16, no. 1 (2023): 93. http://dx.doi.org/10.3390/cancers16010093.

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Evoked from asbestos-induced inflammation, pleural mesothelioma represents a fatal diagnosis. Therapy ranges from nihilism to aggressive multimodality regimens. However, it is still unclear who ultimately benefits from which treatment. We aimed to re-challenge inflammatory-related biomarkers’ prognostic value in times of modern immune-oncology and lung-sparing surgery. The biomarkers (leukocytes, hemoglobin, platelets, neutrophils, lymphocytes, monocytes, neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), C-reactive protein (CRP)) and clinical
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Pass, Harvey I., Jessica S. Donington, Shirish M. Gadgeel, et al. "Plasma osteopontin and the prognosis of pleural mesothelioma." Journal of Clinical Oncology 31, no. 15_suppl (2013): 11109. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.11109.

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11109 Background: Cytoreductive surgery for malignant pleural mesothelioma (MPM) should be reserved for patients with favorable tumor biology. Osteopontin (OPN) and the ratio of absolute neutrophil to absolute lymphocyte counts (NLR) have been reported as possible prognostic biomarkers. These were studied with other clinical/ laboratory variables in a mixed surgical/non-surgical MPM population to define independent predictors of survival (OS) and progression (TTP). Methods: Forty-four MPM patients (12 F, 32M; 26 cytoreduction, 18 no cytoreduction; 31 epithelial, 13 non-epithelial; 15 Stage I/I
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Shagdaleev, R. F., E. A. Toneev, A. A. Martynov, M. A. Belova, and A. D. Teryagova. "Prognostic model and calculator for assessing the risk of prolonged pleural effusion after lobectomy." Pirogov Russian Journal of Surgery, no. 6 (June 2, 2025): 26. https://doi.org/10.17116/hirurgia202506126.

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Objective. To develop a nomogram and risk assessment calculator for prolonged pleural effusion after lobectomy for lung cancer. Material and methods. The study was conducted at the Thoracic Oncology Surgery Department of the Ulyanovsk Regional Oncology Dispensary. Patients who underwent lobectomy between January 1, 2022 and January 1, 2024 were included (database registration state No. 2024622456). There were 78 patients including 48 ones without prolonged pleural effusion (PPE) and 30 ones with this complication. After statistical analysis, data bootstrapping and logistic regression calibrati
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Wirk, Baldeep. "Massive Pleural Effusions and Anasarca After Allogeneic Hematopoietic Cell Transplantation." Blood 116, no. 21 (2010): 4556. http://dx.doi.org/10.1182/blood.v116.21.4556.4556.

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Abstract Abstract 4556 A 37 year old male with T cell acute lymphoblastic leukemia with normal cytogenetics 46XY in second complete remission (CR2) after 8 cycles of HyperCVAD and 4 cycles of salvage nelarabine underwent myeloablative conditioning with cyclophosphamide TBI for a matched related donor allogeneic stem cell transplant from his brother. His day+100 bone marrow biopsy showed CR2 and was 100% donor. His post transplant course was unremarkable until he relapsed d+162. The immunosuppression was tapered off rapidly and 2 cycles of nelarabine and a donor lymphocyte infusion (1×107 CD3 c
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12

Chen, Ruxuan, Yujie Shi, Hui Huang, Mengzhao Wang, and Yan Xu. "Bronchoalveolar lavage fluid analysis in patients with checkpoint inhibitor pneumonitis." Journal of Clinical Oncology 42, no. 16_suppl (2024): e14683-e14683. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e14683.

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e14683 Background: Checkpoint inhibitor pneumonitis (CIP) is a relatively uncommon but potentially life-threatening immune-related adverse event (irAE). Lung biopsies have not been commonly performed for CIP patients. Bronchoalveolar lavage fluid (BALF) analysis is a useful diagnostic approach for interstitial lung disease. However, BALF features were inconsistent across different studies. Methods: We retrospectively reviewed the medical records of 154 patients with pathologically confirmed malignancies and suffering from CIPs between July 2018 and December 2022. Patients who had bronchoalveol
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13

Lim, Jeong Uk, Chang Dong Yeo, Hye Seon Kang, et al. "Prognostic value of platelet count and lymphocyte to monocyte ratio combination in stage IV non-small cell lung cancer with malignant pleural effusion." PLOS ONE 13, no. 7 (2018): e0200341. http://dx.doi.org/10.1371/journal.pone.0200341.

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Kim, Jae-Joon, So Yeon Oh, Kwonoh Park, and Sang-Bo Oh. "Association of ascitic neutrophil to lymphocyte ratio with prognosis in patients with advanced gastric cancer." Journal of Clinical Oncology 38, no. 4_suppl (2020): 443. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.443.

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443 Background: Approximately 40% of metastatic gastric cancer patients develop peritoneal carcinomatosis, and this condition leads patients to grave prognosis. Blood neutrophil to lymphocyte ratio (NLR) is associated with prognosis in various solid tumors, such as non-small cell lung cancer, colorectal cancer, and gastric cancer. We performed this study to investigate the prognostic significance of NLR of ascitic fluid. Methods: This is retrospective study. Patients were consecutive included if they; 1) had histologically confirmed gastric adenocarcinoma, poorly cohesive carcinoma, or poorly
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15

Zhang, Qiao-quan, Yan-fang Zhang, Nian Yu, Xing-jian Lin, and Qing Di. "Differential Diagnosis of Autoimmune Encephalitis from Infectious Lymphocytic Encephalitis by Analysing the Lymphocyte Subsets of Cerebrospinal Fluid." Analytical Cellular Pathology 2019 (December 3, 2019): 1–6. http://dx.doi.org/10.1155/2019/9684175.

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This study is aimed at investigating the lymphocyte subsets of cerebrospinal fluid (CSF) to provide possible differential diagnostic values and better understand the pathophysiological mechanism underlying autoimmune encephalitis (AE) and infectious lymphocytic encephalitis. A series of CD markers, including CD3/4/8/20 representing different types and developmental stages of lymphocytes, were used to count the corresponding subpopulations of CSF from clinical and laboratory confirmed cases of anti-N-methyl-D-aspartate receptor AE (NMDAR-AE), herpes simplex virus encephalitis (HSVE), and tuberc
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16

Mazzella, Antonio, Elena Maiolino, Patrick Maisonneuve, Mauro Loi, and Marco Alifano. "Systemic Inflammation and Lung Cancer: Is It a Real Paradigm? Prognostic Value of Inflammatory Indexes in Patients with Resected Non-Small-Cell Lung Cancer." Cancers 15, no. 6 (2023): 1854. http://dx.doi.org/10.3390/cancers15061854.

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Background (1): Our goal was to investigate if and how pre-operative inflammatory status can influence the long-term prognosis of patients undergoing lung surgery for cancer. Materials and Methods (2): This prospective observational study includes the agreement of all operable patients to the study, who were referred to our department between 1 January 2017 and 30 December 2018. The inflammatory pre-operative status of the patients was investigated by calculating albumin, CPR (c-protein reactive), complete blood count (neutrophils, lymphocytes, platelets, hemoglobin), and some other indexes re
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Porkka, Kimmo, Michele Baccarani, Andreas Hochhaus, et al. "Occurrence, Management, and Outcomes In Patients with Pleural Effusion During Dasatinib Treatment for Chronic-Phase Chronic Myeloid Leukemia (CML-CP) In the First-Line Setting: Analysis of the DASISION Trial." Blood 116, no. 21 (2010): 2282. http://dx.doi.org/10.1182/blood.v116.21.2282.2282.

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Abstract Abstract 2282 Background: The Phase 3 DASISION trial comparing dasatinib 100 mg once daily with imatinib 400 mg once daily as initial treatment in patients (pts) with newly diagnosed CML-CP has demonstrated superior efficacy and favorable safety of dasatinib after a minimum of 12 months of follow-up (Kantarjian, H, et al. N Engl J Med 2010;362:2260). While fluid retention was more frequent with imatinib than with dasatinib, pleural effusion was seen only with dasatinib. Here, we provide a detailed analysis of pts experiencing pleural effusion, a clinically relevant adverse drug reacti
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18

Raznatovska, О. М., V. I. Petrenko, O. S. Shalmin, et al. "Difficulties in Diagnosing of Pancreatic Cancer in HIV Infection with Generalised Lymphadenopathy: Tuberculosis, Non-Tuberculosis Mycobacterial Infection or Metastases (Clinical Case)." Tuberculosis, Lung Diseases, HIV Infection, no. 1 (February 29, 2024): 78–85. http://dx.doi.org/10.30978/tb2024-1-78.

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Our observation of the pancreatic cancer diagnosing difficulties in a patient with HIV infection with generalised lymphadenopathy is presented. The patient’s HIV infection was diagnosed 8 months before hospitalisation, he did not receive antiretroviral therapy. He came to the doctor already in a serious condition, when severe intoxication syndrome, weight loss, abdominal pain radiating to the lower back and diarrhea were noted. The patient was hospitalised in a serious condition, where he spent 42 days. The patient had severe immunosuppression since hospitalisation time (CD4+ lymphocyte count
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Tabe, Yoko, Hiroyuki Takemura, Konobu Kimura, et al. "Novel Flowcytometry-Based Approach for Detection of Tumor Cells in Body Fluid Using Automated Hematology Analyzer." Blood 126, no. 23 (2015): 5600. http://dx.doi.org/10.1182/blood.v126.23.5600.5600.

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Abstract Introduction: Nucleated cells differential analysis of body fluid (BF) samples is important diagnostic tool for several diseases including cancer metastasis. Detection of tumor cells in BF requires the manual morphological scanning of slides by the cytopathologists, which is time-consuming, labor-intensive and not always reliable because of a relatively low overall sensitivity rates (ranging 40-90%) with the higher false-negative rates for lymphomas and mesotheliomas. This study aimed to develop the scattergram gating analysis for detection of tumor cells in BF using the automated hem
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Cuzzubbo, Stefania, Pauline Tetu, Sarah Guegan, et al. "Reintroduction of immune-checkpoint inhibitors after immune-related meningitis: a case series of melanoma patients." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e001034. http://dx.doi.org/10.1136/jitc-2020-001034.

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Immune-checkpoint inhibitors (ICIs) targeting cytotoxic T lymphocyte-associated antigen-4 and programmed cell death ligand-1) are associated with several immune-related neurological disorders. Cases of meningitis related to ICIs are poorly described in literature and probably underestimated. Several guidelines are available for the acute management of these adverse events, but the safety of resuming ICIs in these patients remains unclear. We conducted a retrospective case series of immune-related meningitis associated with ICIs that occurred between October 1 2015 and October 31 2019 in two ce
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Gill, R. S., D. Pace, A. Bazzarelli, et al. "Canadian Surgery Forum1. (CJSEditors' Choice Award) Weight loss and obesity-related outcomes of gastric bypass, sleeve gastrectomy and gastric banding in patients enrolled in a population-based bariatric program: prospective cohort study2. Early outcomes of a small, rural bariatric surgery program3. Is early discharge of patients post-laparoscopic Roux-en-Y gastric bypass safe?4. Defining the learning curve: early experience of laparoscopic Roux-en-Y gastric bypass from a bariatric centre of excellence5. Bariatric surgery in patients with renal disease: Is it safe and is there an optimal approach?6. A comparison of weight loss and follow-up interventions required for sleeve gastrectomy and gastric bypass at a single centre: Is there an optimal procedure for Canada?7. Laparoscopic adjustable gastric band complication and revision rates in a publicly funded obesity program8. The Covidien TriStaple system versus the duet tissue buttress in laparoscopic sleeve gastrectomy: a comparative study9. Three-year outcomes for bariatric surgery in a regionalized surgical care system: the Ontario experience10. The epidemiology of readmission after bariatric surgery in Ontario11. Can recent health service use predict postoperative complications in seniors undergoing colon cancer surgery?12. Appropriateness of transfusions for colorectal surgery (ATRACS): a multi-institutional assessment of current red blood cell transfusion practices13. Catheter fecal management systems can cause life-threatening rectal bleeding: a systematic review14. Tumour budding predicts recurrence after curative resection for T2N0 colorectal cancer15. Different scopes for different folks? A comparison of patient populations and adenoma detection rates for out-patient centre and hospital-based colonoscopies16. Normalization of carcinoembryonic antigen levels postneoadjuvant therapy is a strong predictor of pathologic complete response in rectal carcinoma17. Is laparoscopic resection in select T4 colorectal lesions comparable to open resection for achieving adequate margins?18. Is early discharge following elective oncologic colon resections in select patients safe? Analysis of short-term outcomes19. Rate of positive circumferential radial margins in rectal cancer is dependent on pathologist and surgeon performance and on the definition of a positive CRM: data from Local Health Integration Network 420. Laparoscopic colorectal cancer resection in the obese: a meta-analysis21. Toward standardizing the rectal cancer surgery consent process: the evaluation of the rectal cancer decision aid22. Transanal endoscopic microsurgery for rectal villous tumours: Can we rely solely on preoperative biopsies and the surgeon’s experience?23. The 2-question questionnaire: an initial step in reducing surgical site infections in colorectal surgery using a comprehensive unit-based safety program24. Measuring patient satisfaction within an enhanced recovery after colorectal surgery program25. Rectal exam: knowledge and perception of family medicine residents in the province of Québec26. Transanal endoscopic microsurgery for malignant polyps found at endoscopy27. Transanal endoscopic microsurgery for unanticipated malignancies — this unexpected finding does not affect final outcomes28. Transabdominal versus transanal excision of T1 rectal cancer29. Transanal endoscopic microsurgery for giant polyps — the Manitoba experience30. Time to recurrence as a marker for tumour aggressiveness in colorectal cancer31. Surgical site infections following colorectal surgery for inflammatory bowel disease and diverticulitis32. Sarcopenia is not predictive of anastomotic leak or length of stay following surgery for colorectal cancer33. Oncologic outcomes and undertreatment issues associated with a selective approach to neoadjuvant radiation therapy in patients with cT3N0 rectal cancer: early results from a retrospective cohort34. Surgical outcomes and cost advantages of transanal minimally invasive surgery35. (CJSEditors' Choice Award) To suture or not: a multicentre, randomized, controlled trial of open versus closed management of full thickness transanal endoscopic microsurgery (TEM) rectal lesion resections36. Transanal endoscopic microsurgery: experience of the first 388 procedures at a Canadian colorectal surgery centre37. Combined endoscopic and fluoroscopic approach to colonic stenting: Clinical results from a single centre38. Ten-year experience with self-expanding metal stents as a bridge-to-surgery with curative intent in the treatment of colorectal adenocarcinoma presenting with acute left-sided colonic obstruction39. The effect of an acute care surgery service on the management of appendicitis40. Correlation of CT hypoperfusion complex and clinical hypotension in adult blunt trauma patients41. Endoscopic versus open component separation: systematic review and meta-analysis42. Improving perioperative management of anemia and use of red blood cell transfusions for gastrointestinal surgery — results of a practice survey of general surgeons43. Impact of a hands-on component on learning in the Fundamental Use of Surgical Energy™ (FUSE) curriculum: a randomized-controlled trial in surgical trainees44. Is polyp detection a good surrogate marker for adenoma detection if done by surgeons?45. Do general surgeons need to perform 200 colonoscopies annually to maintain competence?46. The impact of introducing a designated day-time operating room for acute care surgery cases47. Comparing Fundamentals of Laparoscopic Surgery (FLS) and LapVR evaluation metrics ability to predict intraoperative performance of junior residents using a porcine model48. General versus technique specific technical skills assessments — the wheel reinvented49. Do Fundamentals of Laparoscopic Surgery (FLS) and LapVR evaluation metrics predict intra-operative performance?50. Pathway-based application of APACHE 4 scoring in a cohort of surgical abdominal sepsis ICU patients51. Predictors of 5-year local, regional and distant recurrence of breast cancer in a population-based cohort in south-central Ontario52. Safe surgical checklist in a regional hospital: an alternate communication tool53. To CT or not to CT? The influence of computed tomography on the diagnosis and treatment of obese pediatric patients with suspected appendicitis54. Surgical procedure feedback rubric for assessing resident performance in the operating room: interim results of a validity study55. Developing a laparoscopic ventral hernia repair program: a single surgeon’s 8-year experience56. Camera navigation and cannulation: validity evidence for 2 new laparoscopic tasks57. Efficacy of self-assessment in evaluating performance of nonmedical expert roles in surgical residents58. Blood transfusion knowledge of surgical residents: Is an educational intervention effective?59. Effectiveness of suction only for appendicitis60. Trends in the Canadian Surgery Forum (CSF) — analysis of the CSF program over the past decade61. Coaching surgeons: culture eats strategy for breakfast62. Surgical safety checklist: the Calgary experience and attitudes63. (CJSEditors’ Choice Award and CAGS Science Award) Th2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis64. Risk factors for mortality among Canadian patients with Staphylococcus aureus bacteremia: a retrospective cohort study65. Defining needs in improvement of communication: a quantitative and qualitative appraisal of interprofessional pages communications66. Catheter related bloodstream infections due toStaphylococcus aureus: a retrospective review67. Does ultrasound predict intraoperative findings at cholecystectomy? An institutional review68. Unplanned admission following day care laparoscopic cholecystectomy69. Laparoscopic versus open surgical management of perforated peptic ulcer — a comparison of outcomes70. The effect of blocked versus random task practice schedules on the acquisition and retention of surgical skills71. Surgical abdominal sepsis (SABS): insight into inflammatory cytokines in peritoneal fluid and serum during initial source control surgery72. Compliance with evidence-based guidelines in acute pancreatitis: an audit of practices in 8 academic teaching hospitals73. The use of computed tomographic gastrography to aid with laparoscopic gastric resection74. Engaging nurses in the implementation of an enhanced recovery after surgery (ERAS) program75. The identification of critical moments in surgery: How consistent are we?76. Advanced graduate trauma education and quality patient safety programs. United efforts achieve sustained improvements in clinical outcomes. Observations from a rapidly developing country77. Variability in the use of bowel exteriorization for penetrating colon injury: results from the American College of Surgeons Trauma Quality Improvement Program (ACS-TQIP)78. Examining the learning curves of incoming surgical trainees: a national cross-sectional study79. Assessing technical competence in surgical trainees: an international surgical education directorates perspective80. Retention of ultrasound education: A survey of surgical residents81. Laparoscopic versus open surgical management of adhesive small bowel obstruction: a comparison of outcomes82. Early clinical experience and approach with POEM procedure for achalasia83. (CAGS Science Award) “Being cordial” and “being competent”: surgeon’s roles in the operating theatre84. Policy and prevention: Can provincial legislation influence risk of major injury among Canadian children and youth?85. Compliance with evidence-based guidelines of intra-abdominal infections86. Outcomes and costs associated with ICU admission among older adults undergoing emergency abdominal surgery87. General surgery graduates feel prepared for practice, but is there a practice available?88. Oncostatin M modulates early inflammatory responses in a fluid resuscitated model of sepsis89. Evaluating 30-day return to hospital following acute care surgery: a quality improvement study90. Treatment of unresectable intrahepatic cholangiocarcinoma with yttrium-90 radioembolization: a systematic review and pooled analysis91. Conventional transarterial chemoembolization for unresectable liver malignancies: How does it compare with other locoregional therapies? A single-institution experience and review of the literature92. The association of posthepatetctomy hypophosphatemia with recovery from initial liver insufficiency93. Getting started with minimally invasive pancreaticoduodenectomy: lessons learned and comparison to open surgery94. Starting a new laparoscopic liver surgery program: initial experience and improved efficiency95. Activation status of liver transplant patients does not predict ICU volume management in first 24 hours after transplantation96. The impact of pancreaticogastrostomy compared with pancreaticojejunostomy reconstruction after pancreaticoduodenectomy on pancreatic fistula: a meta-analysis of randomized controlled trials97. A comprehensive approach to the prediction of acute calcular cholangitis — the Qatar Experience98. Laparoscopic hepatectomy in patients with liver cirrhosis99. Intraoperative ultrasound and surgical strategy in hepatic resection: What difference does it make?100. Predictors of recurrence of primary sclerosing cholangitis after liver transplantation: a single-centre experience over 20 years101. Surgical planning of hepatic metastasectomy using radiologist performed intraoperative ultrasound102. Arterial resection for cancer of the pancreas (ARCAP) — expanding the resectability criteria for pancreas adenocarcinoma is safe and effective in selected patients103. Outcomes of pylorus-preserving versus conventional whipples’ pancreaticoduodenectomy: insights from the ACS-NSQIP database104. Revisiting randomized trials comparing pancreatico-gastrostomy versus pancreatico-jejunostomy after pancreaticoduodenectomy: a systematic review and meta-analysis105. Acute appendicitis mimicking cholecystitis: case reports and medicolegal aspects106. Canadian practice patterns for pancreaticoduodenectomy107. Surgical trends following the institution of provincial standards for pancreatic cancer resections: a quality assurance study108. Hospital readmission after pancreaticoduodenectomy in a high volume center109. Experienced based design (EBD) improves the delivery of care to patients with pancreatic cancer110. Determining the natural history of pancreatic cystic neoplasms: a Canadian provincial cohort study111. Risk factors for perioperative red blood cell transfusions in liver resection — the importance of operative and intraoperative care112. (CJSEditors’ Choice Award) Simultaneous resection of primary colorectal cancer and synchronous liver metastases: a population-based study113. Lateral approach in laparoscopic distal pancreatectomy is safe and potentially beneficial compared with the traditional medial approach114. Surgical resection for pancreatic head cancer: How well are we doing? A retrospective institutional experience115. Similar outcomes of sterile versus infected walled off pancreatic necrosis treated with combined endoscopic and percutaneous drainage116. Pancreatic adenocarcinoma in young patients: a single institution experience over 32 years117. Factors predictive of pancreaticojejenostomy stenosis post pancreaticoduodenectomy (Whipple’s procedure)118. Hepatobiliary scintigraphy (HBS) for the assessment of the future liver remnant (FRL) in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): Does volume equal function?119. Quality of pancreatic cancer in Nova Scotia using quality indicators120. Variations in medical oncology utilization practices by pancreatic cancer patients in Nova Scotia121. Perioperative morbidity and mortality after pancreatectomy: a systematic review of prediction scores, models and nomograms122. Defining the neuroendocrine tumors landscape: a 15-year population-based analysis of incidence, outcomes and therapies123. Withdrawn124. Repeat cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for patients with peritoneal carcinomatosis from appendiceal and colorectal cancers125. Patient navigation reduces time to care for patients with breast disease126. Predictive ability of blood neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in gastrointestinal stromal tumours (GIST)127. Mucocele of the appendix: an intriguing condition128. Does a multidisciplinary approach improve outcomes in sacral chordoma?129. Why women are choosing mastectomy: influences beyond the surgeon130. A patient-centred approach toward wait times in the surgical management of breast cancer in the province of Ontario131. Results of resection for recurrent or residual retroperitoneal sarcoma after failed primary treatment132. Diagnostic delays: A problem for young women with breast cancer?133. Real-time electromagnetic navigation for breast tumour resection: proof of concept134. Papillary thyroid cancer: epidemiology and clinical implications of bilateral disease135. Mastectomy, contralateral prophylactic mastectomy and immediate breast reconstruction: an institutional review136. The Specimen Margin Assessment Technique (SMART) trial: a novel 3D method of identifying the most accurate method of specimen orientation in breast cancer surgery137. Impact of perioperative red blood cell transfusions on outcomes after liver resection138. The impact of a critical look at the consequences of preoperative MRI in breast cancer patients139. Axillary reverse mapping in breast cancer: a Canadian experience140. Comparing outcomes of open versus flexible and rigid transoral endoscopic techniques for the treatment of Zenker’s diverticulum141. Transthoracic, extracorporeal gastric conduit preparation: a simple alternative to mini-laparotomy in minimally invasive, Ivor-Lewis esophagectomy142. Superiority of video-assisted thoracic surgery (VATS) over open lobectomy: Is this due to the approach or due to the surgeon?143. Predictors of malignant pathology and the role of transthoracic biopsy in solitary fibrous tumours of the pleura144. MicroRNA expression of bronchoalveolar lavage and sputum to distinguish early stage NSCLC patients from cancer-free matched controls145. Results of laryngotracheal resection and anastomosis with posterior cricoidotomy in 31 patients146. Preoperative computed tomography localization of pulmonary arterial branches for lobectomy147. (CJSEditors’ Choice Award) Is it safe to wait? The effect of surgical wait times on survival in non–small cell lung cancer148. Left upper lobe resection using VATS anterior approach with an eparterial tracheal bronchus: a case report149. What is the evidence in evidence based thoracic surgery? Validation of a review protocol and a snap shot of the distribution of publications in thoracic surgery at a global level150. The effect of surgeon volume on procedure selection in non–small cell lung cancer151. Thoracoscopic lobectomy: 5-year outcome and lessons learned from 381 consecutive patients152. Does the usage of a digital chest drainage system reduce pleural inflammation and volume of pleural effusion after major lung resections for cancer? A prospective, randomized study." Canadian Journal of Surgery 57, no. 4suppl1 (2014): S85—S139. https://doi.org/10.1503/cjs.009414.

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Narahari, Narendra Kumar, Nandini Ravula, Rakesh Kodati, et al. "Diagnostic accuracy of cancer ratio and other new parameters in differentiating malignant from benign pleural effusions." Monaldi Archives for Chest Disease, December 6, 2024. https://doi.org/10.4081/monaldi.2024.3131.

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Differentiation of malignant from benign pleural effusions is challenging in clinical practice due to limitations in the cytologic analysis. The combination of pleural fluid biomarkers has previously been used to predict malignant pleural effusion (MPE). We have conducted a prospective observational study to assess the diagnostic potential of cancer ratio [(CR) serum lactate dehydrogenase (sLDH): pleural fluid adenosine deaminase (pADA)], CR plus (CR: pleural lymphocyte count), sLDH: pleural lymphocyte count, and age: pADA in differentiating malignant effusions from benign ones. Prospective da
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Takeuchi, Eiji, Yoshio Okano, Hisanori Machida, et al. "Eosinophilic pleural effusion due to lung cancer has a better prognosis than non-eosinophilic malignant pleural effusion." Cancer Immunology, Immunotherapy, June 25, 2021. http://dx.doi.org/10.1007/s00262-021-02994-5.

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Abstract Objective Tumor-related eosinophilia may have extended survival benefits for some cancer patients. However, there has been no report on the prognosis difference between eosinophilic pleural effusion (EPE) and non-EPE in lung cancer patients. Our study aimed to investigate the prognosis difference between EPE and non-EPE due to lung cancer. Patients and methods We retrospectively reviewed patients diagnosed with lung cancer who presented with malignant pleural effusion (MPE) between May 2007 and September 2020 at the National Hospital Organization Kochi Hospital. EPE is defined as pleu
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Saini, Ankita, Rateesh Sareen, and G. N. Gupta. "High Fluorescent Cells on Automated Body Fluid Analysis as Discriminator for Malignant Cell Detection." South Asian Journal of Cancer, October 27, 2023. http://dx.doi.org/10.1055/s-0043-1776287.

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The automated examination of body fluids (BF) serves as a valuable screening tool for the presence of malignant cells in such samples. Malignant cells are identified as high fluorescence cells (HFC) when analyzed using the Sysmex XN-1000 automated analyzer. This study aimed to assess the correlation between HFC cell counts generated by the automated analyzer and manual cytological examination for detecting malignant cells. Additionally, it sought to establish reliable cutoff values for malignant cells since there is a lack of literature on this subject. Conducted at the department of pathology
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Farooq, Saad, Sabiha Armin, Jordan E. Killingsworth, et al. "Predictors for spontaneous pleurodesis in patients with indwelling pleural catheters for malignant pleural effusion: a safety net hospital experience." Therapeutic Advances in Respiratory Disease 19 (January 2025). https://doi.org/10.1177/17534666251318844.

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Background: Malignant pleural effusion (MPE) affects approximately 150,000 patients in the United States each year and usually signifies advanced-stage cancer. The optimal treatment remains a challenge but indwelling pleural catheters (IPC) offer several advantages and may help achieve spontaneous pleurodesis (SP) in some patients. Objectives: We aim to investigate the predictors of SP among patients with MPE, particularly in a resource-limited community-based safety net hospital. Design: This is a retrospective cohort study done at a community-based safety net hospital. Methods: Adults diagno
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Ng, Isaac KS, Nesaretnam Barr Kumarakulasinghe, Nicholas L. Syn, and Ross Andrew Soo. "Development, internal validation and calibration of a risk score to predict survival in patients with EGFR-mutant non-small cell lung cancer." Journal of Clinical Pathology, June 23, 2020, jclinpath—2020–206754. http://dx.doi.org/10.1136/jclinpath-2020-206754.

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AimsEGFR tyrosine kinase inhibitors (TKIs) are first-line molecularly targeted therapies in patients with advanced non-small cell lung cancer (NSCLC) who carry sensitising EGFR mutations, due to its superior survival outcomes compared with conventional chemotherapy regimens. In this study, we sought to identify clinical, immune and biochemical variables with prognostic significance in this patient subgroup and incorporate them into a nomogram-based risk score.MethodsA total of 199 patients with EGFR mutation-positive, advanced NSCLC (defined as stage IV at initial diagnosis or incurable diseas
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Bai, Earla Lakshmi, Buddaiahgari Swathi, and Siva Chaithanya Bangi. "PATHOLOGICAL STUDY OF BODY FLUIDS IN A TERTIARY CARE CENTER IN SOUTH INDIA." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, November 1, 2021, 60–61. http://dx.doi.org/10.36106/ijsr/5701996.

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Body cavities uid analysis is done routinely in both clinical pathology and cytology departments of Pathological laboratory. Any imbalance between uid 1. formation and removal leads to effusion, as stated by Starling's law The peritoneal, pleural, cerebrospinal and pericardial uids comprise the major chunk of 2 body uids . Accumulation of uid in various body cavities can occur in vast range of benign conditions and it also a frequent clinical presentation and complication of malignant disorder. METHODS: A prospective study was conducted in the Department of Pathology, Osmania general hosp
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Sun, Tao, Jun Liu, Houqin Yuan, Xin Li, and Hui Yan. "Construction of a risk prediction model for lung infection after chemotherapy in lung cancer patients based on the machine learning algorithm." Frontiers in Oncology 14 (August 9, 2024). http://dx.doi.org/10.3389/fonc.2024.1403392.

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PurposeThe objective of this study was to create and validate a machine learning (ML)-based model for predicting the likelihood of lung infections following chemotherapy in patients with lung cancer.MethodsA retrospective study was conducted on a cohort of 502 lung cancer patients undergoing chemotherapy. Data on age, Body Mass Index (BMI), underlying disease, chemotherapy cycle, number of hospitalizations, and various blood test results were collected from medical records. We used the Synthetic Minority Oversampling Technique (SMOTE) to handle unbalanced data. Feature screening was performed
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Zhang, Yanping, Xiangsen Jiang, Wei Ye, and Jinlin Sun. "Clinical features and outcome of eight patients with Chlamydia psittaci pneumonia diagnosed by targeted next generation sequencing." Clinical Respiratory Journal, August 8, 2023. http://dx.doi.org/10.1111/crj.13681.

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AbstractIntroductionThe clinical symptoms of Chlamydia psittaci pneumonia are still poorly understood. This study was designed to summarize the clinical features and outcome of eight C. psittaci pneumonia patients diagnosed by targeted next generation sequencing (tNGS).MethodsWe included eight C. psittaci pneumonia patients admitted to our hospital from January 2021 to July 2022. The tNGS was performed to the samples collected from bronchoalveolar lavage fluid of each patient. Their clinical data were analysed, including baseline features, clinical symptoms, chest radiographic findings and lab
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Cordone, Iole, Serena Masi, Diana Giannarelli, et al. "Major Differences in Lymphocyte Subpopulations Between Cerebrospinal Fluid and Peripheral Blood in Non-Hodgkin Lymphoma Without Leptomeningeal Involvement: Flow Cytometry Evidence of a Cerebral Lymphatic System." Frontiers in Oncology 11 (June 3, 2021). http://dx.doi.org/10.3389/fonc.2021.685786.

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Cerebrospinal fluid (CSF) flow cytometry has a crucial role in the diagnosis of leptomeningeal disease in onco-hematology. This report describes the flow cytometry characterization of 138 CSF samples from patients affected by non-Hodgkin lymphoma, negative for disease infiltration. The aim was to focus on the CSF non-neoplastic population, to compare the cellular composition of the CSF with paired peripheral blood samples and to document the feasibility of flow cytometry in hypocellular samples. Despite the extremely low cell count (1 cell/µl, range 1.0–35) the study was successfully conducted
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