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Rozprawy doktorskie na temat „CAR-Natural Killer and CAR-macrophages”

Autor: Grafiati
Data publikacji: 7 czerwca 2025
Data aktualizacji: 2 sierpnia 2025

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Sprawdź 16 najlepszych rozpraw doktorskich naukowych na temat „CAR-Natural Killer and CAR-macrophages”.

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1

Wang, Shuo [Verfasser], and Peter [Akademischer Betreuer] Hillemanns. "Developing new chimeric antigen receptor (CAR)-engineered natural killer cells targeting ovarian cancer stem cells / Shuo Wang ; Akademischer Betreuer: Peter Hillemanns ; Klinik für Frauenheilkunde und Geburtshilfe." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2017. http://d-nb.info/1144394848/34.

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Wheeler, Elizabeth H. "Natural killer cell activity in mice bearing Lewis lung carcinoma." Virtual Press, 1985. http://liblink.bsu.edu/uhtbin/catkey/416656.

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Natural killer (NK) cells are important in limiting tumor dissemination. The NK activity in C57B1/6 mice bearing Lewis lung carcinoma (LLC) was monitored during tumor development. During the initial period of tumor growth, NK activity was enhanced. As tumor growth progressed, NK activity became suppressed. Depletion of macrophages from the spleen cells of tumor-bearing mice restored the NK cytotoxic response. Plasma prostaglandin E2 (PGE2) concentrations were measured by a radioimmunoassay and found to become elevated during the course of tumor growth. To determine whether the suppressed NK ac
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Lauzon, Wallace Delbert. "The functional characterization of lung-associated natural killer activity and its regulation by alveolar macrophages." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9919.

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The purpose of this study was to characterize the natural killer activity of lymphocytes resident in the rat lung and explore its modulation. Lung lymphocytes (LL) were shown to possess potent NK activity against Yac-1 targets, The effector cells were found to be sensitive to complement-mediated lysis with anti-asialo GM-1 and to treatment with L-leucine methyl ester, which selectively kill NK cells. LL were more potent NK effectors than peripheral blood (PBL) or spleen lymphocytes (SL), although the lung and spleen contained similar proportions of NK (3.2.3 positive) cells. Lung and periphera
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Gentry, Robin G. "Cost and Capability Evaluation of the Marine Corps Combined Arms Regiment (CAR)." Thesis, Monterey, California. Naval Postgraduate School, 1993. http://hdl.handle.net/10945/7611.

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Upon consultation with NPS faculty, the School has determined that this thesis may be released to the public, its distribution is unlimited effective August 25, 2011.<br>One result of the break-up of the Soviet Union is that the DOD has been forced to reevaluate the roles of each of the Armed Services based on the declining resource pool. From the Marine Corps' evaluation of itself came the Combined Arms Regiment (CAR) concept. The objective of this study was to develop an estimate of the Life Cycle Cost (LCC) of the two possible vehicles used with the CAR and the CAR's components. Standard co
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Gustafsson, Charlotte. "Local immune regulation in human pregnancy : with focus on decidual macrophages /." Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1016s.pdf.

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Morris, Kristin Renee. "Inhibition of NFKB by adenovirus E1A in induction of macrophage senstivity [sic] and reduced tumorigencity [sic] in vivo /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Immunology) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 129-141). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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7

Klezovich, Maria. "Dialogue entre les cellules Natural Killer et Bacillus anthracis in vitro et in vivo : rôle dans la réponse immunitaire innée et le contrôle initial de l'infection." Paris 7, 2012. http://www.theses.fr/2012PA077114.

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L'infection par B. Anthracis aboutit à la mort rapide de l'hôte par combinaison d'une infection bactérienne aiguë et d'une toxémie. Les spores de B. Anthracis induisent la production de grandes quantités d'IFN-y par les cellules NK. Cependant, aucune donnée n'était disponible sur le rôle des cellules NK au cours de l'infection par B. Anthracis. Le présent travail visait à explorer les communications entre les cellules NK et B. Anthracis et les différents mécanismes, contact cellulaire et/ou sécrétion de cytokines, qui sont à la base du processus d'activation des cellules NK par B. Anthracis, a
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Calgarotto, Andrana Karla 1983. "Efeitos in vivo e ex vivo de compostos derivados do nitroestireno na resposta imunohematopoética." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309213.

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Orientador: Mary Luci de Souza Queiroz<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T00:13:54Z (GMT). No. of bitstreams: 1 Calgarotto_AndranaKarla_D.pdf: 1646916 bytes, checksum: ca2ab5d61b64cf7aa060ac3c410f1029 (MD5) Previous issue date: 2012<br>Resumo: Neste trabalho avaliamos os efeitos de compostos derivados do nitroestireno, NTS1 e NTS2, sobre a resposta imunohematopoética de camundongos normais e portadores do tumor ascítico de Ehrlich (TAE). O estudo dos mecanismos envolvidos no tratamento de camundongo
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Ramos, Aline Lisie. "Atividade imunomoduladora da alga Chlorella vulgaris em camundongos portadores de tumos ascitico de Ehrlich." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311283.

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Orientador: Mary Luci de Souza Queiroz<br>Tese ( doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-12T11:14:50Z (GMT). No. of bitstreams: 1 Ramos_AlineLisie_D.pdf: 13996403 bytes, checksum: 20b3e94e609f9ce6fd4214680378bb52 (MD5) Previous issue date: 2008<br>Resumo: A Chlorella vulgaris (CV) é uma alga microscópica bastante rica em nutrientes. Além de alto valor nutritivo, a Chlorella tem demonstrado possuir importantes atividades terapêuticas. Vários trabalhos do nosso laboratório e outros demonstram os efeitos protetores des
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10

Russier, Marion. "Cellules NK et fièvres hémorragiques virales : étude de leur rôle dans la mise en place des réponses immunes et dans la pathogenèse lors de l'infection par les virus Lassa et Ebola." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-00835079.

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Les fièvres hémorragiques à virus Lassa (LASV) et Ebola (EBOV) représentent un important problème de santé publique en Afrique. Les réponses immunes et la pathogenèse associées à ces maladies sont peu connues. Les cellules NK ont un rôle important dans la réponse immune innée par leurs propriétés cytotoxiques, mais également dans l'induction des réponses adaptatives par leur production de cytokines et leurs interactions avec les cellules dendritiques (DC) et les macrophages. Ce projet s'attache à comprendre le rôle des cellules NK dans le contrôle de la réplication virale et dans l'induction d
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11

(10283939), Andrea M. Chambers. "IMMUNOTHERAPY OF SOLID TUMORS WITH IMMUNOMETABOLICALLY-RETARGETED NATURAL KILLER CELLS." Thesis, 2021.

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<div>Cancer is responsible for the second highest cause of death in the United States, and lung cancer accounts for 13% of new cancer diagnoses, with the highest rate of cancer death at 24%. Almost 85% of these cases represent non-small cell lung cancer (NSCLC), which includes lung adenocarcinoma, the most common NSCLC subtype. Traditional cancer treatments often only temporarily stop the spread of the disease, but immunotherapies, which are becoming a standard of care, are much more promising. Natural killer (NK) cells are powerful effectors of innate immunity, and genetically engineered NK c
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12

"Study on inflammatory responses of neonatal natural killer cells and macrophages upon lipoteichoic acid stimulation." 2011. http://library.cuhk.edu.hk/record=b5894834.

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Cheng, Siu Fung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 121-141).<br>Abstracts in English and Chinese.<br>Abstract (English) --- p.ii<br>(Chinese) --- p.V<br>Acknowledgements --- p.viii<br>List of Abbreviations --- p.x<br>Table of Contents --- p.xi<br>Chapter Chapter 1 --- Introduction and Literature Reviews --- p.1<br>Chapter 1.1 --- Bacterial Infection in Neonates --- p.1<br>Chapter 1.1.1 --- Overview of Bacterial Infection in Neonates --- p.1<br>Chapter 1.1.2 --- Gram-Positive Bacteria and Infection in Newborns ---
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13

Olson, Chris Martin. "Modulation of Macrophage Responses to Borrelia Burgdorferi in Acute Murine Lyme Carditis." 2009. https://scholarworks.umass.edu/open_access_dissertations/75.

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The Lyme disease spirochete Borrelia burgdorferi is the only known human pathogen that directly activates invariant natural killer T (iNKT) cells. The number and activation kinetics of iNKT cells vary greatly among different strains of mice. Here, we report the role of the iNKT cell response in the pathogenesis of Lyme disease using C57BL/6 (B6) mice, a strain with optimal iNKT cell activation that is resistant to the development of spirochetal-induced inflammation. During experimental infection of B6 mice with B. burgdorferi , iNKT cells localize to the inflamed heart where they are activated
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Ribeiro, Helena Maria Moreira Ferreira Soares. "The relevance of lipid accumulation in lysosomal storage diseases in immune cells function." Doctoral thesis, 2020. http://hdl.handle.net/10773/30452.

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Lysosomal storage diseases (LSDs) are rare genetic diseases in which different molecules accumulate in the lysosome due to defects in lysosomal proteins. Fabry disease, Gaucher disease and Niemann-Pick disease type C (NPC) are LSDs, sphingolipidoses in which there is the accumulation of different sphingolipids in the lysosome while mucopolysaccharidoses (MPS) are characterized by the lysosomal accumulation of glycosaminoglycans. The lysosome is important in lipid antigen presentation mediated by CD1 molecules. In humans, four CD1 isoforms (CD1a, CD1b, CD1c and CD1d) are able to present
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Ciaglia, Elena. "The crosstalk between Dendritic and Natural Killer cells together with the function of Tumor Associated Macrophages (TAM) represent novel cancer-related targets for Human Immunodeficiency Type-1 Protease Inhibitors." Tesi di dottorato, 2009. http://www.fedoa.unina.it/3940/1/ciaglia.pdf.

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Inflammatory conditions and infections in selected organs increase the risk of cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis and subversion of adaptive immunity. The human immunodeficiency virus (HIV) infection is characterized by increased risk of several solid tumors due to its inherent nature of weakening the immune system. Recent observations point to a lower incidence of some cancers in patients treated with protease inhibitor (PI) cocktail such as HAART (Highly Active Anti-Retroviral T
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16

Dessureault, Mireille. "Effet du sécrétome des cellules sénescentes sur la réponse inflammatoire orchestrée par les macrophages." Thèse, 2016. http://hdl.handle.net/1866/18640.

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L’élimination des cellules sénescentes met en jeu le SASP et les cellules immunitaires de l’immunité innée et adaptative tels que les macrophages (Mφ). Dans le cadre de ce projet, nous rapportons que le SASP a un effet pléiotropique sur l’activité des cellules immunitaires incluant leur recrutement, leur activation et leur différenciation. Nos données montrent que les Mφ humains mis en culture avec le SASP de fibroblastes humains développement un profil inflammatoire spécifique au SASP caractérisé par une sécrétion pro-inflammatoire (M1) (ex : IL- 1β, GM-CSF) et des marqueurs de surface anti-i
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