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1

Breukels, Vincent, Wouter G. Touw, and Geerten W. Vuister. "Structural and dynamic aspects of Ca2+ and Mg2+ binding of the regulatory domains of the Na+/Ca2+ exchanger." Biochemical Society Transactions 40, no. 2 (2012): 409–14. http://dx.doi.org/10.1042/bst20110742.

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Intracellular Ca2+ regulates the activity of the NCX (Na+/Ca2+ exchanger) through binding to the cytosolic CBD (Ca2+-binding domain) 1 and CBD2. In vitro studies of the structure and dynamics of CBD1 and CBD2, as well as studies of their kinetics and thermodynamics of Ca2+ binding, greatly enhanced our understanding of NCX regulation. We describe the fold of the CBDs in relation to other known structures and review Ca2+ binding of the different CBD variants from a structural perspective. We also report on new findings concerning Mg2+ binding to the CBDs and finally we discuss recent results on
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2

Tanaka, Takeshi, Shinsuke Fujiwara, Shingo Nishikori, Toshiaki Fukui, Masahiro Takagi, and Tadayuki Imanaka. "A Unique Chitinase with Dual Active Sites and Triple Substrate Binding Sites from the Hyperthermophilic Archaeon Pyrococcus kodakaraensis KOD1." Applied and Environmental Microbiology 65, no. 12 (1999): 5338–44. http://dx.doi.org/10.1128/aem.65.12.5338-5344.1999.

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ABSTRACT We have found that the hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1 produces an extracellular chitinase. The gene encoding the chitinase (chiA) was cloned and sequenced. ThechiA gene was found to be composed of 3,645 nucleotides, encoding a protein (1,215 amino acids) with a molecular mass of 134,259 Da, which is the largest among known chitinases. Sequence analysis indicates that ChiA is divided into two distinct regions with respective active sites. The N-terminal and C-terminal regions show sequence similarity with chitinase A1 from Bacillus circulans WL-12 and chitinas
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Suwatthanarak, Tharathorn, Vitoon Chinswangwatanakul, Asada Methasate, et al. "Surgical strategies for challenging common bile duct stones in the endoscopic era: A comprehensive review of current evidence." World Journal of Gastrointestinal Endoscopy 16, no. 6 (2024): 305–17. http://dx.doi.org/10.4253/wjge.v16.i6.305.

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While endoscopic retrograde cholangiopancreatography (ERCP) remains the primary treatment modality for common bile duct stones (CBDS) or choledocholithiasis due to advancements in instruments, surgical intervention, known as common bile duct exploration (CBDE), is still necessary in cases of difficult CBDS, failed endoscopic treatment, or altered anatomy. Recent evidence also supports CBDE in patients requesting single-step cholecystectomy and bile duct stone removal with comparable outcomes. This review elucidates relevant clinical anatomy, selection indications, and outcomes to enhance surgi
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Shojaiefard, Abolfazl, Majid Esmaeilzadeh, Ali Ghafouri, and Arianeb Mehrabi. "Various Techniques for the Surgical Treatment of Common Bile Duct Stones: A Meta Review." Gastroenterology Research and Practice 2009 (2009): 1–12. http://dx.doi.org/10.1155/2009/840208.

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Common bile duct stones (CBDSs) may occur in up to 3%–14.7% of all patients for whom cholecystectomy is preformed. Patients presenting with CBDS have symptoms including: biliary colic, jaundice, cholangitis, pancreatitis or may be asymptomatic. It is important to distinguish between primary and secondary stones, because the treatment approach varies. Stones found before, during, and after cholecystectomy had also differing treatments. Different methods have been used for the treatment of CBDS but the suitable therapy depends on conditions such as patient' satisfaction, number and size of stone
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KOZIUK, Viktor. "CONFIDENCE TO DIGITAL CURRENCIES OF CENTRAL BANKS: INSTITUTIONAL PARADOX OR AGE MATTERS." WORLD OF FINANCE, no. 2(63) (2020): 08–23. http://dx.doi.org/10.35774/sf2020.02.008.

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Introduction. Technological innovations potentially can change monetary systems. The paper raises important problem of confidence in central bank digital currency (CBDC). Because the level of such confidence is variable across countries, it is assumed, that in the core of confidence in CBDC are non-fundamental factors. The purpose is to share the institutional analysis of money on digital currencies and empirical testing of the hypothesis, that confidence in CBDC is not determined by theoretically-driven factors, yet specific factors like age structure of the population. Results. Basing on ins
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Czauderna, Marian, Tomáš Taubner, and Wiktoria Wojtak. "Comparative Study of Gas and Liquid Chromatography Methods for the Determination of Underivatised Neutral and Acidic Cannabinoids and Cholesterol." Molecules 29, no. 10 (2024): 2165. http://dx.doi.org/10.3390/molecules29102165.

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The aim of our study was to develop a gas chromatographic method coupled with mass spectrometry (GC-MS) for the determination of underivatised neutral (CBDs-N) and acidic (CBDs-A) cannabinoids (CBDs) and cholesterol (Chol). Emphasis was also placed on comparing our original GC-MS method with the currently developed C18-high-performance liquid chromatography with photodiode detection (C18-HPLC-DAD). A combination of a long GC column, shallow temperature column programme, and mass-spectrometry was employed to avoid issues arising from the overlap between CBDs and Chol and background fluctuations
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Ueda, Tatsuki, Masataka Kikuyama, Yuzo Kodama, and Takafumi Kurokami. "Short-Term Biliary Stent Placement Contributing Common Bile Duct Stone Disappearance with Preservation of Duodenal Papilla Function." Gastroenterology Research and Practice 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6153893.

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Aims. To investigate the effect of biliary stent placement without endoscopic sphincterotomy (EST) on common bile duct stones (CBDS) disappearance and the contribution of preserving the duodenal papilla function to reduce recurrence of CBDS.Methods. Sixty-six patients admitted for acute obstructive cholangitis due to CBDS who underwent biliary stent placement without EST for 2 years from March 2011 were evaluated retrospectively. The second endoscopic retrograde cholangiopancreatography (ERCP) was performed for treatment of CBDS 3 to 4 months after the first ERCP. We estimated the rate of ston
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8

Saito, Hirokazu, Tatsuyuki Kakuma, Yoshihiro Kadono, et al. "Increased risk and severity of ERCP-related complications associated with asymptomatic common bile duct stones." Endoscopy International Open 05, no. 09 (2017): E809—E817. http://dx.doi.org/10.1055/s-0043-107615.

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Abstract Background and study aims Endoscopic removal of asymptomatic common bile duct stones (CBDS) is generally recommended. Although many reports have described the risk of complications in endoscopic retrograde cholangiopancreatography (ERCP), no studies have addressed this problem in the context of asymptomatic CBDS. This study examines the risk of complications arising in ERCP for asymptomatic CBDS. Patients and methods This retrospective study included 425 patients with naive papilla who underwent therapeutic ERCP for choledocholithiasis at 2 institutions in Japan for 2 years. The risk
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9

Vindal, Anubhav, Pooja Meena, and Shreya Jain. "Laparoscopic CBD Exploration: Technical Innovations." Annals of Minimal Access Surgery & Allied Science 1, no. 1 (2025): 11–20. https://doi.org/10.4103/amas.amas_13_24.

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Abstract Common bile duct stones (CBDS) are seen commonly in patients undergoing Laparoscopic Cholecystectomy. The management options available for CBDS are varied ranging from open CBD exploration to endoscopic retrograde cholangiopancreatography (ERCP) to laparoscopic CBD exploration. The review dwells on the presentation, diagnosis and management of CBDS and discusses the advantages and disadvantages along with the technical innovations of the various treatment modalities for CBDS.
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10

Ye, Cheng, Wence Zhou, Hui Zhang, Long Miao, Gen Lv, and Abdelwahab Omri. "Alterations of the Bile Microbiome in Recurrent Common Bile Duct Stone." BioMed Research International 2020 (September 29, 2020): 1–7. http://dx.doi.org/10.1155/2020/4637560.

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Objective. Common bile duct stone (CBDS) recurrence is associated with bile microbial structure. This study explored the structure of bile microbiome in patients with recurrent CBDS, and its relationship with the recurrence of CBDS. Methods. Patients with recurrent CBDS (recurrence group) and controls without CBDS (control group) requiring endoscopic retrograde cholangiopancreatography (ERCP) were prospectively included. The control group was noncholelithiasis patients, mainly including benign and malignant biliary stenosis. Bile samples were collected, and bile microbiome structure was analyz
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11

Taha, Abdallah M., Saada Ahmed, Mahmoud Abdelhameid, Ahmad A. Maklad, Mahmoud A. Abozeid, and Mohamed Abdelshafy. "Management of borderline common bile duct stones: Retrospective comparative study." Egyptian Journal of Surgery 42, no. 4 (2023): 987–94. http://dx.doi.org/10.4103/ejs.ejs_196_23.

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Background Borderline Size common bile duct stones (BLS-CBDS) are associated with hepato-pancreato-biliary morbidity and complications. Its optimum management is still controversial till now. Aim Is to compare conservative treatment versus endoscopic retrograde cholangiopancreatography (ERCP) for the treatment of BLS-CBDS. Material and methods This retrospective study included patients with BLS-CBDS less than or equal to 10 mm who were treated conservatively or by ERCP endoscopic stone extraction followed by laparoscopic cholecystectomy (LC). The primary outcome was successful common bile duct
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12

Liu, Jun, and Huiren Hu. "The role of cellulose binding domains in the adsorption of cellulases onto fibers and its effect on the enzymatic beating of bleached kraft pulp." BioResources 7, no. 1 (2012): 878–92. http://dx.doi.org/10.15376/biores.7.1.878-892.

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The adsorption of cellulases onto fibers may be one of the most important factors affecting the enzymatic reaction between cellulases and fibers. This study investigated the adsorption kinetics involved, using isothermal adsorption equations. Cellulose binding domains (CBDs) were isolated from a commercial cellulase, and their role in the adsorption and enzymatic reaction was evaluated. Approximately 13% to 24% of the refining energy was saved after northern bleached softwood kraft pulp samples were pretreated with full cellulase, CBDs, or cellulase lacking CBDs under optimal conditions. The a
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13

Field, Xavier, Chelsea Tong, Sarah Cox, et al. "Outcomes of asymptomatic common bile duct stones detected at intraoperative cholangiography." New Zealand Medical Journal 137, no. 1595 (2024): 73–79. http://dx.doi.org/10.26635/6965.6491.

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aims: The aim of this study was to investigate the outcome of common bile duct stones (CBDS) in asymptomatic patients at laparoscopic cholecystectomy (LC) and intra-operative cholangiogram (IOC). methods: All patients undergoing LC and IOC at Te Whatu Ora – Health New Zealand Waikato between January 2017 and January 2022 were retrospectively reviewed. Electronic records were screened for asymptomatic CBDS. Exclusion criteria were hyperbilirubinaemia, gallstone pancreatitis, cholangitis and imaging-detected CBDS. IOC reports were reviewed to determine presence of CBDS. A second blinded review w
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14

BLACK, Gary W., Jane E. RIXON, Jonathan H. CLARKE, et al. "Evidence that linker sequences and cellulose-binding domains enhance the activity of hemicellulases against complex substrates." Biochemical Journal 319, no. 2 (1996): 515–20. http://dx.doi.org/10.1042/bj3190515.

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Xylanase A (XYLA) and arabinofuranosidase C (XYLC) from Pseudomonas fluorescens subsp. cellulosa are modular enzymes consisting of discrete cellulose-binding domains (CBDs) and catalytic domains joined by serine-rich linker sequences. To evaluate the role of the CBDs and interdomain regions, the capacity of full-length and truncated derivatives of the two enzymes, lacking either the linker sequences or CBDs, to hydrolyse a range of substrates, and bind to cellulose, was determined. Removal of the CBDs did not affect either the activity of XYLA or XYLC against soluble arabinoxylan. Similarly, d
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15

Jie, Na, Xin Cao, Jin Chen, and Xuehong Chen. "A New Method for Identifying the Central Business Districts with Nighttime Light Radiance and Angular Effects." Remote Sensing 15, no. 1 (2022): 239. http://dx.doi.org/10.3390/rs15010239.

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Central business districts (CBDs) play a crucial role in urban economic activities. Thus, the location and boundaries of CBDs identified by the unified standards are essential for comparative analyses in urban geography. However, past research mainly applied specific data or sensitive methods to delimitate CBDs within local knowledge in the case study, there remains no automated standardization technique for identifying and delimitating CBDs across the globe. This paper proposed a new method for identifying CBDs based on nighttime lights (NTL) to overcome the above limitations. The main advant
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Ligthart, Sjors, Tijs Kooijmans, Thomas Douglas, and Gerben Meynen. "Closed-Loop Brain Devices in Offender Rehabilitation: Autonomy, Human Rights, and Accountability." Cambridge Quarterly of Healthcare Ethics 30, no. 4 (2021): 669–80. http://dx.doi.org/10.1017/s0963180121000141.

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AbstractThe current debate on closed-loop brain devices (CBDs) mainly focuses on their use in a medical context; possible criminal justice applications have only received incidental scholarly attention. Unlike in medicine, in criminal justice, CBDs might be offered on behalf of the State and for the purpose of protecting security, rather than realizing healthcare aims. It would be possible to deploy CBDs in the rehabilitation of convicted offenders, similarly to the much-debated possibility of employing other brain interventions in this context. Although such use of CBDs could in principle be
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Peng, Ling-Yun, Ying-Jie Kang, Zong-Rui Lai, and Yu-Ke Deng. "Optimization and Damping Performance of a Coal-Fired Power Plant Building Equipped with Multiple Coal Bucket Dampers." Advances in Civil Engineering 2018 (2018): 1–19. http://dx.doi.org/10.1155/2018/7015019.

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A parameter optimization design method is proposed for multiple coal bucket dampers (CBDs) to reduce the seismic response of coal-fired power plants. To test the damping effect of the optimized CBDs, a 1 : 30 scale shaking table test model of a power plant structure was fabricated. A comparative testing program was conducted using three seismic excitations on a model with and without CBDs. A finite element analysis model, replicating the conditions of the shaking table test, was constructed for comparison, and the shock absorption effects of CBDs subjected to 22 groups of far-field seismic act
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18

Wiktorski, Cody A., Dimitrios Michelogiannakis, P. Emile Rossouw, and Fawad Javed. "The Effect of Charcoal-Based Dentifrice and Conventional Whitening Toothpaste on the Color Stability and Surface Roughness of Composite Resin: A Systematic Review of In Vitro Studies." Dentistry Journal 12, no. 3 (2024): 58. http://dx.doi.org/10.3390/dj12030058.

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The objective was to systematically review studies that evaluated the effect of charcoal-based dentifrices (CbDs) and conventional whitening toothpastes (CWTs) on the color stability (CS) and/or surface roughness (SR) of composite resin (CR). The question we focused on was “Do CbD and CWT affect the CS and/or SR of CR?” Indexed databases were searched without language and time restrictions up to and including May 2023 using different keywords. Original experimental studies were included. The risk of bias (RoB) was assessed using the Quality Assessment Tool for In Vitro Studies. Ten in vitro st
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Kouchi, Katsunori, Ayako Takenouchi, Aki Matsuoka, et al. "Case Series of Endoscopic Papillary Balloon Dilation for Children with Common Bile Duct Stones and a Review of the Literature." Journal of Clinical Medicine 13, no. 8 (2024): 2251. http://dx.doi.org/10.3390/jcm13082251.

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Background: Endoscopic sphincterotomy (EST) has been employed for the endoscopic treatment of common bile duct stones (CBDSs) and has been reported to have a high success rate for stone removal. However, EST is associated with a risk of bleeding, perforation, and sphincter of Oddi function disruption. To avoid these risks, endoscopic papillary balloon dilation (EPBD) is an option for CBDS. Sphincter of Oddi function preservation decreases long-term biliary infection and gallstone recurrence. EPBD may have advantages in children who require a long follow up. However, there have been few reports
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Langerth, A., L. Brandt, A. Ekbom, and B. M. Karlson. "Late Complications following Endoscopic Sphincterotomy for Choledocholithiasis: A Swedish Population-Based Study." Diagnostic and Therapeutic Endoscopy 2014 (October 16, 2014): 1–5. http://dx.doi.org/10.1155/2014/745790.

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In order to assess the risk of long-term complications following endoscopic sphincterotomy (ES) for common bile duct stones (CBDS), we conducted a cohort study. The study included 1,113 patients who underwent ES for CBDS in six different hospitals in central Sweden between 1977 and 1990. Through the use of the Swedish population registry, each patient was assigned five population-based controls matched for sex and age. Linkage to the Inpatient Registry yielded information on morbidity and mortality for the patients as well as for the controls. After one year of washout, there were 964 patients
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Van Dellen, Katrina, Sudip K. Ghosh, Phillips W. Robbins, Brendan Loftus, and John Samuelson. "Entamoeba histolytica Lectins Contain Unique 6-Cys or 8-Cys Chitin-Binding Domains." Infection and Immunity 70, no. 6 (2002): 3259–63. http://dx.doi.org/10.1128/iai.70.6.3259-3263.2002.

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ABSTRACT The Jacob lectin, the most abundant glycoprotein in the cyst wall of Entamoeba invadens, contains five unique 6-Cys chitin-binding domains (CBDs). We identified Entamoeba histolytica and Entamoeba dispar genes encoding Jacob homologues, each of which contains two predicted 6-Cys CBDs. A unique 8-Cys CBD was found at the N termini of the E. histolytica chitinase and three other predicted lectins, called Jessie 1 to Jessie 3. The CBDs of four E. histolytica lectins (Jacob, chitinase, and Jessies 2 and 3) were expressed in secretory vesicles of transfected amebae and shown to bind to par
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Yakovleva, E. V., D. E. Vybornykh, E. G. Gemdzhian, and N. I. Zozulya. "COVID-19 in patients with congenital bleeding disorders in Russia." Russian journal of hematology and transfusiology 68, no. 2 (2023): 219–28. http://dx.doi.org/10.35754/0234-5730-2023-68-2-219-228.

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Background. Internationally published data about the course of COVID-19 in patients with congenital bleeding disorders (CBDs) are limited. There are questions about how COVID-19 affects the course of CBDs and, conversely, how CBDs affect the course of coronavirus infection.Aim — to analyze the course of COVID-19 in patients with CBDs in Russia.Materials and methods. A cross-sectional survey was conducted at the National Medical Research Center for Hematology (Moscow) for the period from June 25 to July 31, 2022. A cluster of 187 patients from different regions and cities of Russia were intervi
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Eugster, Marcel R., and Martin J. Loessner. "Wall Teichoic Acids Restrict Access of Bacteriophage Endolysin Ply118, Ply511, and PlyP40 Cell Wall Binding Domains to the Listeria monocytogenes Peptidoglycan." Journal of Bacteriology 194, no. 23 (2012): 6498–506. http://dx.doi.org/10.1128/jb.00808-12.

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ABSTRACTThe C-terminal cell wall binding domains (CBDs) of phage endolysins direct the enzymes to their binding ligands on the bacterial cell wall with high affinity and specificity. TheListeria monocytogenesPly118, Ply511, and PlyP40 endolysins feature related CBDs which recognize the directly cross-linked peptidoglycan backbone structure ofListeria. However, decoration with fluorescently labeled CBDs primarily occurs at the poles and septal regions of the rod-shaped cells. To elucidate the potential role of secondary cell wall-associated carbohydrates such as the abundant wall teichoic acid
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S, Jotheeshwaran, and Kumaravel A. "Back Pressure Algorithm with CBDS." International Journal of Electronics and Communication Engineering 3, no. 12 (2016): 8–11. http://dx.doi.org/10.14445/23488549/ijece-v3i12p103.

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Sunil, Divya, and S. Shalini. "Capsular Bag Distension Syndrome." Delhi Journal of Ophthalmology 34, no. 2 (2024): 88–94. https://doi.org/10.4103/dljo.dljo_47_24.

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Capsular bag distension syndrome (CBDS) is an uncommon complex condition occurring postcataract surgery, characterized by the progressive enlargement of the capsular bag, leading to various visual disturbances and potential complications. The underlying mechanisms involve a combination of factors, including retained lens material and abnormal capsular dynamics. Diagnosis of CBDS requires a comprehensive ophthalmic examination, often revealing signs such as forward displacement of the intraocular lens, shallowing of the anterior chamber, and refractive changes. Management strategies encompass b
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Saito, Hirokazu, Yoshihiro Kadono, Takashi Shono, et al. "Factors Predicting Difficult Biliary Cannulation during Endoscopic Retrograde Cholangiopancreatography for Common Bile Duct Stones." Clinical Endoscopy 55, no. 2 (2022): 263–69. http://dx.doi.org/10.5946/ce.2021.153.

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Background/Aims: Difficult biliary cannulation is an important risk factor for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Therefore, this study aimed to identify the factors that predict difficult cannulation for common bile duct stones (CBDS) to reduce the risk for PEP.Methods: This multicenter retrospective study included 1,406 consecutive patients with native papillae who underwent ERCP for CBDS. Factors predicting difficult cannulation for CBDS were identified using univariate and multivariate analyses.Results: Univariate analysis showed that six factors
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Ahmadi, Seyed Esmaeil, Mohammad Jazebi, Gholamreza Bahoush, Mohammad Reza Baghaipour, Fereydoun Ala, and Shadi Tabibian. "Congenital Combined Bleeding Disorders, a Comprehensive Study of a Large Number of Iranian Patients." Clinical and Applied Thrombosis/Hemostasis 27 (January 1, 2021): 107602962199681. http://dx.doi.org/10.1177/1076029621996813.

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Congenital combined bleeding disorders (CBDs) are extremely rare disorders which mainly occur in regions with a high rate of consanguineous marriage. These disorders can present with a variety of symptoms ranging from mucocutaneous bleeding to life-threatening episodes. This study aims to evaluate the prevalence and clinical course of Iranian patients with congenital CBDs. This study is conducted on 450 patients with CBDs who were referred to the Iranian Comprehensive Hemophilia Care Center (ICHCC) between 2010 and 2020. All these patients were diagnosed through evaluation of past medical hist
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Fukuba, Nobuhiko, Shunji Ishihara, Hiroki Sonoyama, et al. "Proton pump inhibitor is a risk factor for recurrence of common bile duct stones after endoscopic sphincterotomy – propensity score matching analysis." Endoscopy International Open 05, no. 04 (2017): E291—E296. http://dx.doi.org/10.1055/s-0043-102936.

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Abstract Background and study aims Recurrence of common bile duct stones (CBDS) in patients treated with endoscopic sphincterotomy (ES) can lead to deterioration in their quality of life. Although the pathology and related factors are unclear, we speculated that proton pump inhibiter (PPI) administration increases the risk of CBDS recurrence by altering the bacterial mixture in the bile duct. Patients and methods The primary endpoint of this retrospective study was recurrence-free period. Several independent variables considered to have a relationship with CBDS recurrence including PPI use wer
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Zha, Xu-Le, Xin-Bo Yu, Hong-Yan Zhang, et al. "Identification of Peritrophins and Antiviral Effect of Bm01504 against BmNPV in the Silkworm, Bombyx mori." International Journal of Molecular Sciences 21, no. 21 (2020): 7973. http://dx.doi.org/10.3390/ijms21217973.

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The insect midgut secretes a semi-permeable, acellular peritrophic membrane (PM) that maintains intestinal structure, promotes digestion, and protects the midgut from food particles and pathogenic microorganisms. Peritrophin is an important PM protein (PMP) in the PM. Here, we identified 11 peritrophins with 1–16 chitin binding domains (CBDs) comprising 50–56 amino acid residues. Multiple CBDs in the same peritrophin clustered together, rather than by species. The CBD contained six highly conserved cysteine residues, with the key feature of amino acids between them being CX11-15CX5CX9-14CX11-1
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Boulton, Stephen, Madoka Akimoto, Bryan VanSchouwen, et al. "Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR." Biochemical Society Transactions 42, no. 2 (2014): 302–7. http://dx.doi.org/10.1042/bst20130282.

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Eukaryotic CBDs (cAMP-binding domains) control multiple cellular functions (e.g. phosphorylation, guanine exchange and ion channel gating). Hence the manipulation of cAMP-dependent signalling pathways has a high translational potential. However, the ubiquity of eukaryotic CBDs also poses a challenge in terms of selectivity. Before the full translational potential of cAMP signalling can be tapped, it is critical to understand the structural basis for selective cAMP agonism and antagonism. Recent NMR investigations have shown that structurally homologous CBDs respond differently to several CBD l
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Jarábková, Veronika, Lenka Tišáková, and Andrej Godány. "Phage Endolysin: A Way To Understand A Binding Function Of C-Terminal Domains A Mini Review." Nova Biotechnologica et Chimica 14, no. 2 (2015): 117–34. http://dx.doi.org/10.1515/nbec-2015-0021.

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AbstractEndolysins are bacteriophage-encoded peptidoglycan hydrolases, which are synthesized in the end of phage reproduction cycle, in an infected host cell. Usually, for endolysins from phages that infect Gram-positive bacteria, a modular structure is typical. Therefore, these are composed of at least two separate functional domains: an N-terminal catalytic domain (EAD) and a C-terminal cell wall binding domain (CBD). Specific ligand recognition of CBDs and following peptidoglycan (PG) binding mostly allows a rapid lytic activity of an EAD. Here we briefly characterize phage endolysin CBDs i
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Howard, Kirsten, Sarah J. Lord, Anthony Speer, Robert N. Gibson, Robert Padbury, and Brendon Kearney. "Value of magnetic resonance cholangiopancreatography in the diagnosis of biliary abnormalities in postcholecystectomy patients: A probabilistic cost-effectiveness analysis of diagnostic strategies." International Journal of Technology Assessment in Health Care 22, no. 1 (2006): 109–18. http://dx.doi.org/10.1017/s0266462306050902.

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Background:Endoscopic retrograde cholangiopancreatography (ERCP) is considered the gold standard for imaging of the biliary tract but is associated with complications. Less invasive imaging techniques, such as magnetic resonance cholangiopancreatography (MRCP), have a much lower complication rate. The accuracy of MRCP is comparable to that of ERCP, and MRCP may be more effective and cost-effective, particularly in cases for which the suspected prevalence of disease is low and further intervention can be avoided. A model was constructed to compare the effectiveness and cost-effectiveness of MRC
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Aryal, S., K. Panthee, and K. Neupane. "Clinical Study on Congenital Birth Defects in a Tertiary Hospital, Western Nepal." Devdaha Medical Journal 5, no. 2 (2023): 20–26. http://dx.doi.org/10.3126/dmj.v5i2.69795.

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Introduction: Congenital Birth Defect (CBD) is one of the commonly encountered problems in neonatal period and major birth defects contribute significantly to neonatal morbidity and mortality. Minor anomalies are frequently seen in newborn which are not detrimental to health but may be associated with major defects serving as a clue for diagnosing more serious underlying defect. Our purpose of study is to determine burden of CBDs, clinical profile and outcome of those neonates born with CBDs admitted in Neonatal Intensive care Unit (NICU) and Obstetric Unit of Devdaha Medical College. Methods:
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Syrén, Eva-Lena, Gabriel Sandblom, Staffan Eriksson, Arne Eklund, Bengt Isaksson, and Lars Enochsson. "Postoperative rendezvous endoscopic retrograde cholangiopancreaticography as an option in the management of choledocholithiasis." Surgical Endoscopy 34, no. 11 (2019): 4883–89. http://dx.doi.org/10.1007/s00464-019-07272-1.

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Abstract Background Rendezvous endoscopic retrograde cholangiopancreaticography (ERCP) is a well-established method for treatment of choledocholithiasis. The primary aim of this study was to determine how different techniques for management of common bile duct stone (CBDS) clearance in patients undergoing cholecystectomy have changed over time at tertiary referral hospitals (TRH) and county/community hospitals (CH). The secondary aim was to see if postoperative rendezvous ERCP is a safe, effective and feasible alternative to intraoperative rendezvous ERCP in the management of CBDS. Methods Dat
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35

Murashima, Koichiro, Akihiko Kosugi, and Roy H. Doi. "Site-Directed Mutagenesis and Expression of the Soluble Form of the Family IIIa Cellulose Binding Domain from the Cellulosomal Scaffolding Protein of Clostridium cellulovorans." Journal of Bacteriology 187, no. 20 (2005): 7146–49. http://dx.doi.org/10.1128/jb.187.20.7146-7149.2005.

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ABSTRACT The planar and anchoring residues of the family IIIa cellulose binding domain (CBD) from the cellulosomal scaffolding protein of Clostridium cellulovorans were investigated by site-directed mutagenesis and cellulose binding studies. By fusion with maltose binding protein, the family IIIa recombinant wild-type and mutant CBDs from C. cellulovorans were expressed as soluble forms. Cellulose binding tests of the mutant CBDs indicated that the planar strip residues played a major role in cellulose binding and that the anchoring residues played only a minor role.
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Pejovic, Tomislav, and Miroslav Stojadinovic. "Scoring system development and validation for prediction choledocholithiasis before open cholecystectomy." Srpski arhiv za celokupno lekarstvo 143, no. 11-12 (2015): 681–87. http://dx.doi.org/10.2298/sarh1512681p.

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Introduction. Accurate precholecystectomy detection of concurrent asymptomatic common bile duct stones (CBDS) is key in the clinical decision-making process. The standard preoperative methods used to diagnose these patients are often not accurate enough. Objective. The aim of the study was to develop a scoring model that would predict CBDS before open cholecystectomy. Methods. We retrospectively collected preoperative (demographic, biochemical, ultrasonographic) and intraoperative (intraoperative cholangiography) data for 313 patients at the department of General Surgery at Gornji Milanovac fr
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Muange, Annastacia Katuvee, John Kariuki, and James Mwitari. "Evaluation of community-based disease surveillance systems for priority disease detection in Nairobi County Kenya." International Journal Of Community Medicine And Public Health 8, no. 10 (2021): 4692. http://dx.doi.org/10.18203/2394-6040.ijcmph20213763.

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Background: Community based disease surveillance (CBDS) may be defined as an active process of community involvement in identification, reporting, responding to and monitoring diseases and public health events of concern in the community. The scope of CBS is limited to systematic continuous collection of health data on events and diseases guided by simplified lay case definitions and reporting to health facilities for verification, investigation, collation, analysis and response as necessary.Methods: A cross sectional study design, interventions study program was adopted to determine the effec
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Mardešić, Ivan, Zvonimir Boban, Witold Karol Subczynski, and Marija Raguz. "Membrane Models and Experiments Suitable for Studies of the Cholesterol Bilayer Domains." Membranes 13, no. 3 (2023): 320. http://dx.doi.org/10.3390/membranes13030320.

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Cholesterol (Chol) is an essential component of animal cell membranes and is most abundant in plasma membranes (PMs) where its concentration typically ranges from 10 to 30 mol%. However, in red blood cells and Schwann cells, PMs Chol content is as high as 50 mol%, and in the PMs of the eye lens fiber cells, it can reach up to 66 mol%. Being amphiphilic, Chol molecules are easily incorporated into the lipid bilayer where they affect the membrane lateral organization and transmembrane physical properties. In the aqueous phase, Chol cannot form free bilayers by itself. However, pure Chol bilayer
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Singh, Manmeet, and Sudhakar Potti. "Capsular bag distension syndrome with sulcus IOL acting as a seal." Indian Journal of Ophthalmology - Case Reports 4, no. 3 (2024): 719–21. http://dx.doi.org/10.4103/ijo.ijo_926_24.

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Capsular bag distension syndrome (CBDS) is a rare complication following cataract surgery with posterior chamber intraocular lens (IOL) implantation. We describe the case of a 68-year-old female who developed early-onset CBDS of her left eye after manual small-incision cataract surgery with implantation of posterior chamber IOL in the sulcus (Excel PMMA IOL (polymethyl methacrylate), Manufactured by Excel Optics (P) Limited, Chennai). The patient had an uneventful cataract surgery performed by a resident in training. Her immediate postoperative uncorrected vision was 20/40, but it decreased to
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LOUCKY, JOHN PAUL. "Improving access to target vocabulary using computerized bilingual dictionaries." ReCALL 14, no. 2 (2002): 295–314. http://dx.doi.org/10.1017/s0958344002000721.

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This study aims to compare various computerized bilingual dictionaries (henceforth CBDs) for their relative effectiveness in helping Japanese college students at several language proficiency levels to access new English target vocabulary. Its rationale was based on several observations and research claims (see Atkins & Knowles, 1990; Bejoint & Moulin, 1987; Laufer & Hadar, 1997) that bilingual and bilingualized dictionaries in general, as well as electronic dictionaries in particular appear to be much more rapid and effective than monolingual book dictionaries for the acquisition o
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Ortega, Ruben, Nicholas Christensen, and Saad Tabet. "Cavity-Backed Dual-Sinuous Antenna Modeling." Applied Computational Electromagnetics Society 35, no. 11 (2021): 1300–1301. http://dx.doi.org/10.47037/2020.aces.j.351119.

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Recently, for Radio Frequency (RF) signal identification on air vehicles, it has become critical to not only be able to detect the direction and angle of arrival of signals, but to also properly identify the polarization of such signals. For decades, cavity-backed dual-spiral antennas were heavily used for this purpose. However, that required the placement of both right-hand and left-hand elements to perform this function. Due to limited space and other issues, an alternative type of broadband antenna had to be identified. The Cavity-Backed Dual-Sinuous (CBDS) antenna makes an excellent replac
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42

Zhou, Jiangping, and Yuling Yang. "The death and life of restaurants: A visualization in the eras of easy online ordering and increased metro mobility." Environment and Planning A: Economy and Space 51, no. 4 (2019): 820–22. http://dx.doi.org/10.1177/0308518x19834307.

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Like pubs in Western countries, restaurants in China are not just places where people consume drinks and eat food. They are also venues where acquaintances, friends, colleagues and families meet, relax, entertain, talk and socialize. In the era of fast-paced life, Fordism, easy online ordering and increased metro mobility, what could happen to restaurants in cities? To answer this, we collected and processed two distinct years (2014 and 2017) of point of interest and metro network data in Shenzhen, China. The visuals based on the data indicate that most metro station areas saw the advent of ne
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43

Schmelcher, Mathias, Tatiana Shabarova, Marcel R. Eugster, et al. "Rapid Multiplex Detection and Differentiation of Listeria Cells by Use of Fluorescent Phage Endolysin Cell Wall Binding Domains." Applied and Environmental Microbiology 76, no. 17 (2010): 5745–56. http://dx.doi.org/10.1128/aem.00801-10.

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ABSTRACT The genus Listeria comprises food-borne pathogens associated with severe infections and a high mortality rate. Endolysins from bacteriophages infecting Listeria are promising tools for both their detection and control. These proteins feature a modular organization, consisting of an N-terminal enzymatically active domain (EAD), which contributes lytic activity, and a C-terminal cell wall binding domain (CBD), which targets the lysin to its substrate. Sequence comparison among 12 different endolysins revealed high diversity among the enzyme's functional domains and allowed classificatio
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Phiri, John, Gina M. Smith, Felix Tembo, et al. "Introduction of subcutaneous depot medroxyprogesterone acetate through use of community-based distributors in Zambia." Gates Open Research 3 (May 28, 2019): 1474. http://dx.doi.org/10.12688/gatesopenres.13020.1.

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Background: The majority of women in Sub-Saharan countries including Zambia use intramuscular Depot Medroxyprogesterone Acetate (DMPA IM) as their preferred method of contraception. However, nearly one-third of the women who start on DMPA IM discontinue within 12 months due to access barriers. Sayana® Press, low-dose, prefilled subcutaneous depot medroxyprogesterone acetate (DMPA-SC), suitable for even lower-level healthcare providers and potential for self-injection administration, has been developed. This pilot aimed to understand the feasibility of DMPA-SC in Zambia through use of community
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Zhang, Chunming, Yingjiang Wu, Wanping Liu, and Xiaofan Yang. "Fixation Probabilities on Complete Star and Bipartite Digraphs." Discrete Dynamics in Nature and Society 2012 (2012): 1–21. http://dx.doi.org/10.1155/2012/940465.

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This paper exactly formulates thekth-order fixation probabilities on complete star digraphs (CSDs), which extend the results from Broom and Rychtář (2008). By applying these probability formulae, some asymptotic properties on CBDs are analyzed, and certain CSDs are determined to be amplifiers of selection for arbitrary relative fitness larger than 1, while all the CSDs are proved to be amplifiers of selection for fixed relative fitness slightly larger than 1. A numerical method for fixed population structure (by solving a linear system) is developed to calculate the fixation probabilities on c
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BOLAM, David N., Antonio CIRUELA, Simon McQUEEN-MASON, et al. "Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity." Biochemical Journal 331, no. 3 (1998): 775–81. http://dx.doi.org/10.1042/bj3310775.

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To investigate the mode of action of cellulose-binding domains (CBDs), the Type II CBD from Pseudomonas fluorescenssubsp. cellulosaxylanase A (XYLACBD) and cellulase E (CELECBD) were expressed as individual entities or fused to the catalytic domain of a Clostridium thermocellumendoglucanase (EGE). The two CBDs exhibited similar Ka values for bacterial microcrystalline cellulose (CELECBD, 1.62×106 M-1; XYLACBD, 1.83×106 M-1) and acid-swollen cellulose (CELECBD, 1.66×106 M-1; XYLACBD, 1.73×106 M-1). NMR spectra of XYLACBD titrated with cello-oligosaccharides showed that the environment of three
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47

Sadek, Mohamed, Mohammed M. Mohammed, Mina Makram Hendy, Saleh Khairy Saleh, and Mohamed A. Abdelzaher. "Prediction of common bile duct stones in acute cholecystitis patients at time of hospital admission." Egyptian Journal of Surgery 42, no. 2 (2023): 433–38. http://dx.doi.org/10.4103/ejs.ejs_81_23.

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Background Early diagnosis of common bile duct stone (CBDS) is crucial since its presence affects surgical therapy and acute calculous cholecystitis (ACC) has a comparable clinical picture whether or not a CBDS is present. Aim At the time of hospital admission, we sought to discover predictors of CBD stones in acute cholecystitis (AC) patients. Methods Between January 2020 and December 2022, we chose 90 patients who had typical ACC and had previously visited the emergency room at Minia University Hospital in Egypt. The 90 AC patients were split into two groups: the 63 AC patients without CBD s
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Gupta, Sonal, Sanjay Chaudhary, Divya Vermani, Hema Mehra, and Alka Pandey. "Management of Late onset Capsular Bag Distension Syndrome with Capsular Bag Lavage." Delhi Journal of Ophthalmology 34, no. 4 (2024): 306–8. https://doi.org/10.4103/dljo.dljo_134_24.

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Capsular bag distention syndrome (CBDS) is one of the rare causes of decrease in vision following cataract surgery with signs such as a shallower anterior chamber, unexpected myopic vision, and the build-up of fluid between the implanted lens and the posterior capsule. We report a patient with late onset diminution of vision, following uneventful phacoemulsification with continuous curvilinear capsulorhexis (CCC) and in-the-bag intra ocular lens (IOL) implantation: Post capsular bag lavage the CBDS resolved immediately with no complications and the vision improved to 6/9 after 2 weeks post op.
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Cann, Isaac K. O., Svetlana Kocherginskaya, Michael R. King, Bryan A. White, and Roderick I. Mackie. "Molecular Cloning, Sequencing, and Expression of a Novel Multidomain Mannanase Gene from Thermoanaerobacterium polysaccharolyticum." Journal of Bacteriology 181, no. 5 (1999): 1643–51. http://dx.doi.org/10.1128/jb.181.5.1643-1651.1999.

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ABSTRACT The manA gene of Thermoanaerobacterium polysaccharolyticum was cloned in Escherichia coli. The open reading frame of manA is composed of 3,291 bases and codes for a preprotein of 1,097 amino acids with an estimated molecular mass of 119,627 Da. The start codon is preceded by a strong putative ribosome binding site (TAAGGCGGTG) and a putative −35 (TTCGC) and −10 (TAAAAT) promoter sequence. The ManA of T. polysaccharolyticum is a modular protein. Sequence comparison and biochemical analyses demonstrate the presence of an N-terminal leader peptide, and three other domains in the followin
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Liu, Jun, and Hui Ren Hu. "Treatment of NBKP with Cellulase to Reduce the Refining Energy Consumption in Production of Grease Proof Paper." Advanced Materials Research 236-238 (May 2011): 1379–84. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.1379.

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Refining is an energy-intensive papermaking process where energy consumption contributes about 18% of the total manufacturing cost. Through the application of cellulases before refining, mills can reduce their energy requirement for refining of pulps and realize the aim of energy consumption. In the present study, two kinds of cellulase within or wothout the cellulose binding domains (CBDs) were used to treat the pulp aimed at reducing the refining energy consumption in production of grease proof paper. In order to compare and evaluate these effects on reducing the pulp refining energy consump
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