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Artykuły w czasopismach na temat „CD44 antigen”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Escribano, Luis, Alberto Orfao, Jesús Villarrubia, et al. "Immunophenotypic Characterization of Human Bone Marrow Mast Cells. A Flow Cytometric Study of Normal and Pathological Bone Marrow Samples." Analytical Cellular Pathology 16, no. 3 (1998): 151–59. http://dx.doi.org/10.1155/1998/341340.

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The goal of the present paper was to define the immunophenotype of bone marrow mast cells (BMMC) from healthy controls and patients with hematologic malignancies (HM) based on the use of multiple stainings with monoclonal antibodies analyzed by flow cytometry. Our results show that BMMC from both groups of individuals display a similar but heterogenous immunophenotype. The overall numbers of BMMC are higher in the HM group of individuals (p= 0.08). Three patterns of antigen expression were detected: (1) markers constantly positive in all cases analyzed (CD9, CD29, CD33, CD43, CD44, CD49d, CD49

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2

Shirure, Venktesh S., Tiantian Liu, Luis F. Delgadillo, et al. "CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions." American Journal of Physiology-Cell Physiology 308, no. 1 (2015): C68—C78. http://dx.doi.org/10.1152/ajpcell.00094.2014.

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Adhesion of circulating tumor cells to vascular endothelium is mediated by specialized molecules that are functional under shear forces exerted by hematogenous flow. Endothelial E-selectin binding to glycoforms of CD44 mediates shear-resistant cell adhesion in numerous physiological and pathological conditions. However, this pathway is poorly understood in breast cancer and is the focus of the present investigation. All breast cancer cell lines used in this study strongly expressed CD44. In particular, BT-20 cells expressed CD44s and multiple CD44v isoforms, whereas MDA-MB-231 cells predominan

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3

HERMIDA-GÓMEZ, TAMARA, ISAAC FUENTES-BOQUETE, MARIA JOSÉ GIMENO-LONGAS, et al. "Quantification of Cells Expressing Mesenchymal Stem Cell Markers in Healthy and Osteoarthritic Synovial Membranes." Journal of Rheumatology 38, no. 2 (2010): 339–49. http://dx.doi.org/10.3899/jrheum.100614.

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Objective.To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial membranes from human osteoarthritic (OA) and healthy joints.Methods.Synovial membranes from OA and healthy joints were digested with collagenase and the isolated cells were cultured. Synovial membrane-derived cells were phenotypically characterized for differentiation experiments using flow cytometry to detect the expression of mesenchymal markers (CD29, CD44, CD73, CD90, CD105, CD117, CD166, and STRO-1) and hematopoietic markers (CD34 and CD45). Chondrogenesis was assessed by staining for proteoglycans and

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4

Sallusto, F., and A. Lanzavecchia. "Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha." Journal of Experimental Medicine 179, no. 4 (1994): 1109–18. http://dx.doi.org/10.1084/jem.179.4.1109.

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Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic cells in vivo. These cells have typical dendritic morphology, express high levels of major histocompatibility complex (MHC) class I and class II molecules, CD1, Fc gamma RII, CD40, B7, CD44, and ICAM-1, and lack CD14. Cultured DCs are highly stimulatory in mixed leukocyte reaction (MLR) and are also capable of triggering cord blood naive T cell

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5

Kansas, GS, MJ Muirhead, and MO Dailey. "Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans." Blood 76, no. 12 (1990): 2483–92. http://dx.doi.org/10.1182/blood.v76.12.2483.2483.

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Abstract We have used three-color flow cytometry to investigate the pattern of expression of the CD11/CD18, CD44, and leukocyte adhesion molecule 1 (LAM-1) adhesion molecules during myeloid and erythroid differentiation in humans. The earliest myeloid cells, identified as CD33loCD15-, were exclusively CD44hi but contained both leukocyte function-associated antigen 1 (LFA-1hi) and LFA-1lo cells, as well as LAM-1+ and LAM-1- cells. This CD33loCD15- myeloid subpopulation expressed only low levels of CD11c and failed to express CD11b, CD14, or any lymphoid (CD3, CD16, CD19) antigens or glycophorin

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6

Kansas, GS, MJ Muirhead, and MO Dailey. "Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans." Blood 76, no. 12 (1990): 2483–92. http://dx.doi.org/10.1182/blood.v76.12.2483.bloodjournal76122483.

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We have used three-color flow cytometry to investigate the pattern of expression of the CD11/CD18, CD44, and leukocyte adhesion molecule 1 (LAM-1) adhesion molecules during myeloid and erythroid differentiation in humans. The earliest myeloid cells, identified as CD33loCD15-, were exclusively CD44hi but contained both leukocyte function-associated antigen 1 (LFA-1hi) and LFA-1lo cells, as well as LAM-1+ and LAM-1- cells. This CD33loCD15- myeloid subpopulation expressed only low levels of CD11c and failed to express CD11b, CD14, or any lymphoid (CD3, CD16, CD19) antigens or glycophorin. Commitm

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7

Mancuso, Patrizia, Ines Martin Padura, Giuliana Gregato, et al. "CD45-CD34+ Endothelial Progenitor Cells (EPCs) from Human Adipose Tissue Promote Tumor Growth and Metastases." Blood 118, no. 21 (2011): 2208. http://dx.doi.org/10.1182/blood.v118.21.2208.2208.

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Abstract Abstract 2208 A catalytic role has been proposed in neoplastic angiogenesis and cancer progression for bone marrow-derived endothelial progenitor cells (EPCs). However, in preclinical and clinical studies the quantitative role of marrow-derived EPCs in cancer vascularization was found to be extremely variable. Adipose tissue represents an attractive source of autologous adult stem cells due to its abundance and surgical accessibility. Lipotransfer aspirates (LAs) from patients undergoing breast reconstruction after breast cancer surgery were analyzed by six colors flow cytometry and t

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8

Parsons, SF, J. Jones, DJ Anstee, et al. "A novel form of congenital dyserythropoietic anemia associated with deficiency of erythroid CD44 and a unique blood group phenotype [In(a-b- ), Co(a-b-)]." Blood 83, no. 3 (1994): 860–68. http://dx.doi.org/10.1182/blood.v83.3.860.860.

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Abstract We have used a panel of well-characterized monoclonal antibodies (MoAbs) to examine the blood cells of a patient with a novel form of congenital dyserythropoietic anemia (CDA) characterized by intra- erythroblastic and intra-erythrocytic membranous inclusions. Twelve antibodies defining three nonoverlapping epitope groups on the extracellular domain of CD44 all failed to react with the red blood cells (RBCs) of the patient. A rabbit antibody to the cytoplasmic domain of CD44 from normal RBCs failed to react with the patient's RBC ghosts. In contrast, the patient's lymphocytes, granulo

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9

Parsons, SF, J. Jones, DJ Anstee, et al. "A novel form of congenital dyserythropoietic anemia associated with deficiency of erythroid CD44 and a unique blood group phenotype [In(a-b- ), Co(a-b-)]." Blood 83, no. 3 (1994): 860–68. http://dx.doi.org/10.1182/blood.v83.3.860.bloodjournal833860.

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We have used a panel of well-characterized monoclonal antibodies (MoAbs) to examine the blood cells of a patient with a novel form of congenital dyserythropoietic anemia (CDA) characterized by intra- erythroblastic and intra-erythrocytic membranous inclusions. Twelve antibodies defining three nonoverlapping epitope groups on the extracellular domain of CD44 all failed to react with the red blood cells (RBCs) of the patient. A rabbit antibody to the cytoplasmic domain of CD44 from normal RBCs failed to react with the patient's RBC ghosts. In contrast, the patient's lymphocytes, granulocytes, an

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10

Rappa, G., F. Anzanello, and A. Lorico. "CD24 expression and breast cancer stem cell phenotype." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11106. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11106.

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11106 Background: Several studies suggest the existence of breast cancer-initiating cells (BCIC), responsible for tumor development and progression. Initial reports that only the CD44+CD24−/low subpopulation contains BCIC have been challenged by subsequent studies. We examined the relationship between CD24 and biological properties of breast cancer cells. Methods: MA-11 breast carcinoma cells, originating from bone marrow micrometastases, are CD44+ and have an heterogeneous expression of CD24 (214,000/cell; range 0–1,120,000). We have previously reported that upon in vitro culture as mammosphe

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11

Schuurhuis, Gerrit J., Rolf Wouters, Angèle Kelder, et al. "Specificity of Markers of Leukemia Initiating Cells with a New Multiparameter Flow Cytometry Based Appraoch; Impact for Prognostic and Therapeutic Applications." Blood 116, no. 21 (2010): 1834. http://dx.doi.org/10.1182/blood.v116.21.1834.1834.

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Abstract Abstract 1834 Leukemia stem cells (LSC) are proposed to underly relapse of AML. In order to develop methods to specifically detect LSCs and to design LSC specific therapies, discrimination between LSC and normal hematopoietic stem cells (HSC) is a prerequisite. HSC and LSC may be either CD34-positive (CD34+CD38-) or CD34-negative. The latter may be contained in stem cell compartments defined by functional parameters: Hoechst 33342 efflux (side population, SP) and ALDH activity. To discriminate between LSCs and HSCs aberrant cell surface markers have been described. Additional flowcyto

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12

Marlina, Marlina, Rizki Rahmadian, Armenia Armenia, et al. "Isolation, Characterization, Proliferation and Differentiation of Synovial Membrane-derived Mesenchymal Stem Cells (SM-MSCs) from Osteoarthritis Patients." Molecular and Cellular Biomedical Sciences 4, no. 2 (2020): 76. http://dx.doi.org/10.21705/mcbs.v4i2.100.

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Background: Mesenchymal stem cells (MSCs) are the cells which has high renewal capacity and and are capable for differentiating into some types of cells. MSCs can be obtained from several tissues including bone marrow, synovial membrane, blood, adipose tissue and periosteum. The proliferation and self-repair ability of MSCs are the advantages to use as stem cells-based therapy of various diseases. The aim of this study was to determine the differentiation, characterization and priliferation of synovial membrane-derived MSCs (SM-MSCs).Materials and Methods: The cells proliferation capacity was

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13

Florian, Stefan, Karoline Sonneck, Alexander W. Hauswirth, Maria-Theresa Krauth, Wolfgang R. Sperr, and Peter Valent. "Phenotyping of Neoplastic (CD34+/CD38−/CD123+) Stem Cells in Myeloid Malignancies Reveals Expression of Multiple Molecular Targets." Blood 106, no. 11 (2005): 1381. http://dx.doi.org/10.1182/blood.v106.11.1381.1381.

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Abstract Recent data suggest that myeloid neoplasms are organized hierarchically in terms of self renewal and maturation of early progenitor cells, similar to normal myelopoiesis. In acute myeloid leukemia (AML), the NOD/SCID mouse-repopulating leukemic stem cells usually co-express CD123 with CD34, but lack CD38. So far, however, little is known about expression of other markers and targets on these progenitors. In the present study, expression of target antigens on CD34+/CD38− cells was analyzed by multicolor flow cytometry in patients with AML (n=18), myelodysplastic syndromes (MDS, n=6), c

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14

Gillig, Marc A., Sukrut H. Karandikar, and Pramod K. Srivastava. "Activation of virtual memory CD8+ T cells specific for self antigens requires antigen presentation by CD11c+ cells." Journal of Immunology 204, no. 1_Supplement (2020): 140.19. http://dx.doi.org/10.4049/jimmunol.204.supp.140.19.

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Abstract Even in experimentally naïve mice, a significant fraction of CD8+ T cells express CD44, a marker associated with previous exposure to cognate antigen. Many of these cells express additional hallmarks of the memory phenotype, leading to questions about their specificity, development, and functional relevance. It has been suggested that lymphopenic conditions experienced by early T cells in prenatal/neonatal mice can give rise to these unexpected “virtual” memory T cells. However, their antigen specificity remains largely unknown. Here, we report several peptide sequences derived from s

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15

Vicente, A., A. Varas, R. S. Acedón, E. Jiminez, J. J. Mulqoz, and A. G. Zapata. "Appearance and Maturation of T-Cell Subsets During Rat Thymus Ontogeny." Developmental Immunology 5, no. 4 (1998): 319–31. http://dx.doi.org/10.1155/1998/24239.

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In previous papers, we have described the ontogenetical development of thymic stromal-cell components (epithelium, macrophages, dendritic cells) of Wistar rats. Here, we correlate those results with the maturation of rat T-cell precursors along the fetal and postnatal life. First T-cell precursors, which colonize the thymus anlage around days 13-14 of gestation, largely express CD45, CD43, CD53, and Thy 1 cell markers, and in a lesser proportion the OX22 antigen. Rat CD3-CD4-CD8-thymocytes present in the earliest stages of gestation could be subdivided in three major cell subpopulations accord

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16

Zhang, Bao Yue, Hui Xue Song, Tan Chen, and Zhan Hui Wang. "A Microfluidic Platform for Multi-Antigen Immunofluorescence Assays." Applied Mechanics and Materials 108 (October 2011): 200–205. http://dx.doi.org/10.4028/www.scientific.net/amm.108.200.

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Traditional cell-based assays such as cell immunoassay that utilizes plastic (chamber slides, dishes, microtiter plates), Magnetic bead, enzyme-linked immunsorbent assays (ELISA) [1], FACS cell sorting is labor intensive, time consuming, and requires a large numbers of cells or reagents. In this report, a microfluidic device integrated with cell culture, washing, fixation, and antigen-antibody reaction is presented for high-throughput immunoassay. Using this microfluidic device, each assay can be performed on a small number of cells and nanolitre or picolitre of reagents, this is particularly

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17

Camp, R. L., T. A. Kraus, M. L. Birkeland, and E. Puré. "High levels of CD44 expression distinguish virgin from antigen-primed B cells." Journal of Experimental Medicine 173, no. 3 (1991): 763–66. http://dx.doi.org/10.1084/jem.173.3.763.

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The in vitro polyclonal stimulation of B cells through their surface immunoglobulin (Ig) induces substantial increases in CD44 protein levels within 24 hours, whereas other stimuli (e.g., lipopolysaccharide, phorbol 12,13 dibutyrate, and interleukin 4) fail to significantly upregulate CD44. The marked increase in CD44 protein expression on anti-Ig-treated B lymphocytes correlates with an increase in CD44-specific mRNA. Cell sorting experiments with B cells isolated from trinitrophenyl-keyhole limpet hemocyanin-immunized mice demonstrate that both short-term antigen-specific, IgG-secreting cell

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18

Hamann, K. J., T. L. Dowling, S. P. Neeley, J. A. Grant, and A. R. Leff. "Hyaluronic acid enhances cell proliferation during eosinopoiesis through the CD44 surface antigen." Journal of Immunology 154, no. 8 (1995): 4073–80. http://dx.doi.org/10.4049/jimmunol.154.8.4073.

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Abstract We examined the effect of hyaluronic acid in promoting proliferation of undifferentiated progenitor cells through the CD44 receptor during eosinopoiesis in vitro. Undifferentiated umbilical cord blood cells were purified on the first day to isolate primitive progenitor cells expressing the CD34 hemopoietic surface marker. Culture in wells coated with 100 micrograms/ml hyaluronic acid caused a 198 +/- 28.7% augmentation of proliferation of CD34+ progenitor cells at 3 wk (p &lt; 0.01). By contrast, concentrations of hyaluronic acid &gt; 10 micrograms/ml inhibited proliferation o

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19

Griffioen, Arjan W., Marieke J. H. Coenen, Cora A. Damen, et al. "CD44 Is Involved in Tumor Angiogenesis; an Activation Antigen on Human Endothelial Cells." Blood 90, no. 3 (1997): 1150–59. http://dx.doi.org/10.1182/blood.v90.3.1150.

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Abstract CD44 is described to be an activation molecule in a number of different cell types. We investigated the role of CD44 on human endothelial cells (EC) and in tumor angiogenesis. Using flow cytometry we showed that EC from the vasculature of human solid tumors display an enhanced expression of CD44 as compared to EC from normal tissue. This finding was confirmed by immunohistochemical studies on frozen tissue sections. Because tumors are dependent on angiogenesis, the role of angiogenic stimuli in the enhanced CD44 expression was investigated. We found that basic fibroblast growth factor

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Griffioen, Arjan W., Marieke J. H. Coenen, Cora A. Damen, et al. "CD44 Is Involved in Tumor Angiogenesis; an Activation Antigen on Human Endothelial Cells." Blood 90, no. 3 (1997): 1150–59. http://dx.doi.org/10.1182/blood.v90.3.1150.1150_1150_1159.

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CD44 is described to be an activation molecule in a number of different cell types. We investigated the role of CD44 on human endothelial cells (EC) and in tumor angiogenesis. Using flow cytometry we showed that EC from the vasculature of human solid tumors display an enhanced expression of CD44 as compared to EC from normal tissue. This finding was confirmed by immunohistochemical studies on frozen tissue sections. Because tumors are dependent on angiogenesis, the role of angiogenic stimuli in the enhanced CD44 expression was investigated. We found that basic fibroblast growth factor (bFGF )

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21

Weiss, Johannes M., Jonathan Sleeman, Andreas C. Renkl, et al. "An Essential Role for CD44 Variant Isoforms in Epidermal Langerhans Cell and Blood Dendritic Cell Function." Journal of Cell Biology 137, no. 5 (1997): 1137–47. http://dx.doi.org/10.1083/jcb.137.5.1137.

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Upon antigen contact, epidermal Langerhans cells (LC) and dendritic cells (DC) leave peripheral organs and home to lymph nodes via the afferent lymphatic vessels and then assemble in the paracortical T cell zone and present antigen to T lymphocytes. Since splice variants of CD44 promote metastasis of certain tumors to lymph nodes, we explored the expression of CD44 proteins on migrating LC and DC. We show that upon antigen contact, LC and DC upregulate pan CD44 epitopes and epitopes encoded by variant exons v4, v5, v6, and v9. Antibodies against CD44 epitopes inhibit the emigration of LC from

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22

Carrette, Florent, Roberto Tinoco, Monique Barraza, and Linda Bradley. "CD44 controls T cell exhaustion and viral persistence during chronic viral infection (VIR10P.1170)." Journal of Immunology 194, no. 1_Supplement (2015): 216.8. http://dx.doi.org/10.4049/jimmunol.194.supp.216.8.

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Abstract During a chronic viral infection, inhibitory receptors play a crucial role in controlling viral persistence and T cell exhaustion. However, the role of homing molecules in this process has been poorly investigated. Using the chronic LCMV virus model, Clone 13, we found that expression of CD44, a cell surface glycoprotein broadly used to identify activated T cells, dampens antigen specific T cell responses. In CD44-deficient hosts, we observed a significant increase in antigen specific CD4 and CD8 T cells functions with decreased PD-1 expression and a striking increase in multiple cyto

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23

Dzudzilo, Madara, Regīna Kleina, Ingrīda Čēma, Anita Dabuzinskiene, and Šimons Svirskis. "Expression and Localisation of CD44 Antigen as a Prognostic Factor of Oral Leukoplakia." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 75, no. 2 (2021): 68–74. http://dx.doi.org/10.2478/prolas-2021-0012.

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Abstract It is essential to identify markers that could indicate the presence of early molecular changes in premalignant tissues like oral leukoplakia (OL). CD44 adhesion molecule is not only a stem cell marker, but also determines cell proliferation and migration in malignant processes. The aim of our study was to assess the amount and pattern of CD44 antigen expression by epithelial and mononuclear cells in the lamina propria under OL and their role in premalignant lesions. The current study included 102 cases of OL and ten biopsies from healthy oral mucosa. Immunohistochemical CD44 antigen

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24

Sperr, WR, HC Bankl, G. Mundigler, et al. "The human cardiac mast cell: localization, isolation, phenotype, and functional characterization." Blood 84, no. 11 (1994): 3876–84. http://dx.doi.org/10.1182/blood.v84.11.3876.bloodjournal84113876.

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We have isolated and characterized the human cardiac mast cell (CMC) and compared this novel mast cell (MC type with MC obtained from uterus, skin, and lung. Heart tissue was obtained from 14 patients with cardiomyopathy (CMP, heart transplantation). CMC were isolated by enzymatic digestion using collagenase, pronase-E, hyaluronidase, and DNAse. Substantial amounts of CMC (0.5% to 1.5% of isolated cells) were found in the atrial appendages but not in ventricular digests or other sites of the heart (< 0.1%). In situ staining of atrial tissue revealed the presence of CMC in the myocardium (2.

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Wang, Yange, Chenyang Li, Xinlei Qi, et al. "A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma." International Journal of Molecular Sciences 23, no. 15 (2022): 8799. http://dx.doi.org/10.3390/ijms23158799.

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Blood group antigen is a class of heritable antigenic substances present on the erythrocyte membrane. However, the role of blood group antigens in cancer prognosis is still largely unclear. In this study, we investigated the expression of 33 blood group antigen genes and their association with the prognosis of 30 types of cancers in 31,870 tumor tissue samples. Our results revealed that blood group antigens are abnormally expressed in a variety of cancers. The high expression of these antigen genes was mainly related to the activation of the epithelial-mesenchymal transition (EMT) pathway. Hig

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26

Oelschlaegel, Uta, Kirsten Poppe-Thiede, Kristina Hoelig, Martin Bornhaeuser, Gerhard Ehninger, and Frank Kroschinsky. "Differences in the Expression of Adhesion Molecules and Mobilization Efficacy in Healthy Stem Cell Donors and Patients with Hematologic Malignancies." Blood 104, no. 11 (2004): 2879. http://dx.doi.org/10.1182/blood.v104.11.2879.2879.

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Abstract Stem cell mobilization is achieved by short term administration of G-CSF in healthy donors and G-CSF +/− chemotherapy in patients with malignant diseases. It is known that the crosstalk between adhesion molecules, bone marrow microenvironment, and cytokines facilitates the multi step process of stem cell mobilization from bone marrow to peripheral blood. But still, the biological basis of the large variability in mobilization efficacy remains unclear. The aim of the present study was to evaluate if poor and good mobilizers - healthy donors as well as patients with hematologic malignan

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27

Collado, Antonia, Antonia de Andres, Encarnación Cañadas, et al. "Characterization of CD44 Antigen during Lymphoid Ontogeny." Immunobiology 183, no. 1-2 (1991): 1–11. http://dx.doi.org/10.1016/s0171-2985(11)80181-6.

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Cheung, Sarah K. C., Po-Kai Chuang, Han-Wen Huang та ін. "Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells". Proceedings of the National Academy of Sciences 113, № 4 (2015): 960–65. http://dx.doi.org/10.1073/pnas.1522602113.

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The discovery of cancer stem cells (CSCs), which are responsible for self-renewal and tumor growth in heterogeneous cancer tissues, has stimulated interests in developing new cancer therapies and early diagnosis. However, the markers currently used for isolation of CSCs are often not selective enough to enrich CSCs for the study of this special cell population. Here we show that the breast CSCs isolated with CD44+CD24-/loSSEA-3+ or ESAhiPROCRhiSSEA-3+ markers had higher tumorigenicity than those with conventional markers in vitro and in vivo. As few as 10 cells with CD44+CD24-/loSSEA-3+ formed

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van der Voort, Robbert, Robert M. J. Keehnen, Esther A. Beuling, Marcel Spaargaren, and Steven T. Pals. "Regulation of Cytokine Signaling by B Cell Antigen Receptor and Cd40-Controlled Expression of Heparan Sulfate Proteoglycans." Journal of Experimental Medicine 192, no. 8 (2000): 1115–24. http://dx.doi.org/10.1084/jem.192.8.1115.

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Recently, biochemical, cell biological, and genetic studies have converged to reveal that integral membrane heparan sulfate proteoglycans (HSPGs) are critical regulators of growth and differentiation of epithelial and connective tissues. As a large number of cytokines involved in lymphoid tissue homeostasis or inflammation contain potential HS-binding domains, HSPGs presumably also play important roles in the regulation of the immune response. In this report, we explored the expression, regulation, and function of HSPGs on B lymphocytes. We demonstrate that activation of the B cell antigen rec

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Kishi, H., D. M. Su, A. Muraguchi, and T. Watanabe. "A novel cell surface antigen, immature thymocyte antigen-1, is involved in the differentiation of murine thymocytes." Journal of Immunology 155, no. 2 (1995): 568–77. http://dx.doi.org/10.4049/jimmunol.155.2.568.

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Abstract A mAb, 1-23, which recognizes a novel cell surface Ag on immature murine thymocytes (designated as IMT-1 for immature thymocyte antigen-1) was prepared. IMT-1 was found to be expressed on 40 to 50% of CD4-8- double negative (DN), 5 to 10% of CD4-8+, and 5 to 20% of CD4+8+ double positive (DP) thymocytes in adult mice, but not expressed on CD4+8- thymocytes or peripheral T lymphocytes. It was not expressed on either nonlymphoid cell lines or thymic stromal cells. In subsets of DN thymocytes, IMT-1 was detected on 40 to 50% of the heat-stable Ag+, 15% of CD44+25+, 70% of CD44-25+, and 7

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Jaggupilli, Appalaraju, and Eyad Elkord. "Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity." Clinical and Developmental Immunology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/708036.

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Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CSCs have been a major challenge. Many studies were performed on surface markers for potential identification and isolation of CSCs. Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and m

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Min, Yoo-Hong, Ji Yeon Kim, Hoi Kyung Jeung, Seung Tae Lee, and June-Won Cheong. "Ligation of CD44 by A3D8 Monoclonal Antibody Induces Terminal Differentiation of THP-1 Leukemia Cells by Promoting Cross-Talk between Extracellular Signal-Regulated Kinase and Phosphoinositide-3 Kinase/Akt Signaling Pathway." Blood 104, no. 11 (2004): 4460. http://dx.doi.org/10.1182/blood.v104.11.4460.4460.

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Abstract Ligation of CD44 with anti-CD44 monoclonal antibody A3D8 induces terminal differentiation of human leukemia cells. However, the underlying molecular mechanisms remain largely unknown. In this study, we examined the importance of MEK/ERK, p38 MAPK, and phosphatidylinositol 3-kinase (PI3-K)/Akt pathway in A3D8-induced monocytic differentiation of THP-1 leukemia cells. THP-1 cells displayed cytologic changes typical of mature monocytes and an increased expression of monocyte-specific antigen CD14 (49% ± 4%) and of myeloid-specific antigen CD11b (68% ± 6%) after 3 days of A3D8 treatment.

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Utama, Bobby Indra. "ISOLATION OF AMNIOTIC FLUID MESENCHYMAL STEM CELLS (AF-MSCs) OBTAINED FROM CAESAREAN SECTIONS." JOURNAL OBGIN EMAS 2, no. 1 (2019): 1–9. http://dx.doi.org/10.25077/aogj.2.1.1-9.2018.

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Amniotic fluid is a liquid that fills the amniotic cavity which has defense and nutritional functions in fetal development. Human aterm amniotic fluid can be an ideal alternative as a source of mesenchymal stem cells, originating from the neonate. Preclinical studies of second and third trimester amnion fluid cells confirmed the number of potential donors from this wasted material. In several studies, AF-MSCs express mesenchymal markers such as CD90, CD73 (SH3, SH), CD105 (SH2), CD29, CD166, CD49e, CD58 and CD44 (MHC class I). These cells also express HLA-ABC antigens, CD 34, CD 45 which are h

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Brown, T. A., T. Bouchard, T. St John, E. Wayner, and W. G. Carter. "Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons." Journal of Cell Biology 113, no. 1 (1991): 207–21. http://dx.doi.org/10.1083/jcb.113.1.207.

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We previously identified a 90-kD (GP90), collagen-binding, membrane glycoprotein, termed extracellular matrix receptor III (ECMR III), that is homologous to the lymphocyte homing receptor and CD44 antigen (Gallatin, W. M., E. A. Wayner, P. A. Hoffman, T. St. John, E. C. Butcher, and W. G. Carter. 1989. Proc. Natl. Acad. Sci. USA. 86:4654-4658). CD44 is abundantly expressed in many epithelial tissues, and is localized predominantly to filopodia in cultured keratinocytes. Here we establish CD44 as a polymorphic family of related membrane proteoglycans and glycoproteins possessing extensive diver

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Ng, David P., and Brent Wood. "Unsupervised Discovery of Early Markers of Erythroid Maturation in Human Donor Marrow." Blood 124, no. 21 (2014): 4304. http://dx.doi.org/10.1182/blood.v124.21.4304.4304.

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Abstract Antigenic expression during erythroid maturation is not well understood. Despite the large number of surface antigens currently described for leukocytes, only a few (e.g. CD36, CD45, CD71, CD117, and CD235a) have been well characterized on erythroid cells. Here, we apply novel bioinformatic tools to select antigens with high potential for identifying successive stages of erythroid maturation in an unsupervised and unbiased manner from a high dimensional dataset. In brief, flow cytometry was performed on 3 normal donor bone marrows using Becton-Dickinson lyoplates containing a total of

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Milde, Kerstin F., Rodolfo Alejandro, Daniel H. Mintz, and Ricardo L. Pastori. "Molecular cloning of the canine CD44 antigen cDNA." Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1218, no. 1 (1994): 112–14. http://dx.doi.org/10.1016/0167-4781(94)90111-2.

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Croft, M., D. D. Duncan, and S. L. Swain. "Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements." Journal of Experimental Medicine 176, no. 5 (1992): 1431–37. http://dx.doi.org/10.1084/jem.176.5.1431.

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Because of the low frequency of T cells for any particular soluble protein antigen in unprimed animals, the requirements for naive T cell responses in specific antigens have not been clearly delineated and they have been difficult to study in vitro. We have taken advantage of mice transgenic for the V beta 3/V alpha 11 T cell receptor (TCR), which can recognize a peptide of cytochrome c presented by IEk. 85-90% of CD4+ T cells in these mice express the transgenic TCR, and we show that almost all such V beta 3/V alpha 11 receptor-positive cells have a phenotype characteristic of naive T cells,

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Lai, Xiaoyu, He Huang, Li Huang, and Fenfang Zeng. "Isolation of Human Bone Marrow Mesenchymal Stem Cells by a Novel Monoclonal Antibody, ZUC3." Blood 108, no. 11 (2006): 2562. http://dx.doi.org/10.1182/blood.v108.11.2562.2562.

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Abstract Objective: Due to absence of a single definitive marker of mesenchymal stem cells (MSCs) and low incidence in human bone marrow, the primary culture of MSCs, conventionally isolated with its characteristic of adherent, were considered to be heterogeneous containing of several subpopulations, which had currently limited our understanding of their biology and therapeutic applications. In our previous study, a novel murine monoclonal antibody (McAb) ZUC3 was produced by hybridoma technology, which was specifically reactive with human MSCs, while showed negative cross-reactivity when scre

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Cizkova, Katerina, Jakub Malohlava, and Zdenek Tauber. "Cell Membrane Nanostructure is Altered by Heat-Induced Antigen Retrieval: A Possible Consequence for Immunocytochemical Detection of Membranous Antigens." Microscopy and Microanalysis 26, no. 1 (2019): 139–47. http://dx.doi.org/10.1017/s1431927619015113.

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AbstractHeat-induced antigen retrieval (HIAR) treatment improves the antigen immunodetection in formalin-fixed, paraffin-embedded tissue samples and it can also improve the detection of intracellular antigens in alcohol-fixed cytological samples, although it could deleteriously impact immunodetection, particularly that of membranous antigens. We examined the differences in cell surface topography on MCF7 cells fixed in methanol/acetone (M/A) or 4% paraformaldehyde (4% PFA), as well as the changes caused by HIAR treatment at three different temperatures (60, 90, and 120°C), using atomic force m

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Camp, R. L., A. Scheynius, C. Johansson, and E. Puré. "CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation." Journal of Experimental Medicine 178, no. 2 (1993): 497–507. http://dx.doi.org/10.1084/jem.178.2.497.

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The in vivo administration of certain monoclonal antibodies (mAbs) against the adhesion receptor, CD44, into normal mice induces both a modulation of CD44 from the surface of peripheral lymphocytes, and a concomitant increase in the amount of soluble CD44 in the serum. CD44-negative lymphocytes isolated from anti-CD44-treated mice exhibit normal homing patterns upon adoptive transfer, and are capable of reexpressing CD44 upon activation. The treatment of haptensensitized mice with anti-CD44 mAb inhibits their ability to mount a cutaneous delayed-type hypersensitivity (DTH) response within the

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Maltzman, J. S., J. A. Carman, and J. G. Monroe. "Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes." Molecular and Cellular Biology 16, no. 5 (1996): 2283–94. http://dx.doi.org/10.1128/mcb.16.5.2283.

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The immediate-early gene egr-1 encodes a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream activation events through the regulation of previously unidentified target genes. Here we identify the gene encoding the lymphocyte homing and migration protein CD44 as a target of EGR1 regulation in B cells. BCR-induced increases in CD44 mRNA expression and transcription levels are shown to occur in EGR1-expressing but not in nonexpressing subclones of the B-cell line WEHI-231. Kinetics of egr-1 transcription and the appearance of nuclear EGR1 protein precede CD4

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Utama, Bobby Indra. "ISOLATION OF AMNIOTIC FLUID MESENCHYMAL STEM CELLS (AF-MSCs) OBTAINED FROM CAESAREAN SECTIONS." JOURNAL OBGIN EMAS 2, no. 1 (2019): 1–9. http://dx.doi.org/10.25077/aoj.2.1.1-9.2018.

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Amniotic fluid is a liquid that fills the amniotic cavity which has defense and nutritional functions in fetal development. Human aterm amniotic fluid can be an ideal alternative as a source of mesenchymal stem cells, originating from the neonate. Preclinical studies of second and third trimester amnion fluid cells confirmed the number of potential donors from this wasted material. In several studies, AF-MSCs express mesenchymal markers such as CD90, CD73 (SH3, SH), CD105 (SH2), CD29, CD166, CD49e, CD58 and CD44 (MHC class I). These cells also express HLA-ABC antigens, CD 34, CD 45 which are h

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Huang, Tzuu-Yuan, Jun-ichi Kuratsu, Hideo Takeshima, Toru Nishi, and Yukitaka Ushio. "Expression of CD44 adhesion molecules in intracranial germinomas." Neurosurgical Focus 5, no. 1 (1998): E5. http://dx.doi.org/10.3171/foc.1998.5.1.6.

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Adhesion molecules play a role in tumor growth, invasiveness, and the metastatic process. The expression of CD44 adhesion molecules in 11 intracranial germinoma specimens was investigated using anti-CD44 monoclonal antibody and immunohistochemical methods. In six of 11 specimens studied, CD44 antibodies were bound to the membrane of tumor cells; in five of six specimens, CD44 antigen was also present in the cytoplasm of tumor cells. The only three patients who showed CD44-positive expression in tumor cells, lymphocytes, and extracellular matrix (ECM) exhibited either cerebrospinal fluid dissem

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McKinney-Freeman, Shannon L., Olaia Naveiras, Frank Yates, et al. "Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells." Blood 114, no. 2 (2009): 268–78. http://dx.doi.org/10.1182/blood-2008-12-193888.

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Abstract Surface antigens on hematopoietic stem cells (HSCs) enable prospective isolation and characterization. Here, we compare the cell-surface phenotype of hematopoietic repopulating cells from murine yolk sac, aorta-gonad-mesonephros, placenta, fetal liver, and bone marrow with that of HSCs derived from the in vitro differentiation of murine embryonic stem cells (ESC-HSCs). Whereas c-Kit marks all HSC populations, CD41, CD45, CD34, and CD150 were developmentally regulated: the earliest embryonic HSCs express CD41 and CD34 and lack CD45 and CD150, whereas more mature HSCs lack CD41 and CD34

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Stanomir, Alina, Carmen Mihaela Mihu, Simona Rednic, et al. "Oral Mesenchymal Stromal Cells in Systemic Sclerosis: Characterization and Response to a Hyaluronic-Acid-Based Biomaterial." Applied Sciences 11, no. 17 (2021): 8101. http://dx.doi.org/10.3390/app11178101.

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Introduction. As oral mesenchymal stromal cells (MSCs) have not, to date, been isolated from systemic sclerosis (SSc) patients, the aim of this in vitro experiment was to characterize gingival MSCs (SScgMSCs) and granulation tissue MSCs (SScgtMSCs) from SSc and to evaluate their functionality in comparison to healthy MSCs (hMSCs), in normal or hyaluronic acid (HA) culture media. Materials and Methods. Isolated cells were described by immunophenotyping of surface antigen make-up and by trilineage mesenchymal differentiation capacity. Colony-Forming Unit-Fibroblast (CFU-F) test and migration pot

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Koopman, G., Y. van Kooyk, M. de Graaff, C. J. Meyer, C. G. Figdor, and S. T. Pals. "Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA-1 pathway." Journal of Immunology 145, no. 11 (1990): 3589–93. http://dx.doi.org/10.4049/jimmunol.145.11.3589.

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Abstract The CD44 molecule, a molecule which has been previously known as Hermes, Pgp-1, extracellular matrix receptor III, and In(Lu)-related p80, is currently thought to be involved in several steps of normal immune cell function, including lymphocyte adhesion to high endothelial venules and to the extracellular matrix and T cell activation. We now demonstrate that triggering of CD44 on T lymphocytes by anti-CD44 mAb promotes cell adhesion. The induced homotypic adhesion is mediated by lymphocyte function-associated antigen-1 (LFA-1), because it was inhibited by anti-LFA-1 antibodies and not

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Koopman, G., K. H. Heider, E. Horst, et al. "Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44." Journal of Experimental Medicine 177, no. 4 (1993): 897–904. http://dx.doi.org/10.1084/jem.177.4.897.

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A recently described splice variant of CD44 expressed in metastasizing cell lines of rat tumors, has been shown to confer metastatic potential to nonmetastasizing rat pancreatic carcinoma and sarcoma cell lines. Using antibodies raised against a bacterial fusion protein encoded by variant CD44 sequences, we have explored the expression of variant CD44 glycoproteins on human lymphoid cells and tissues and on non-Hodgkin's lymphomas. Normal lymphohematopoietic cells express barely detectable low levels of variant CD44 glycoproteins, whereas T lymphocytes, upon activation by mitogen or antigen, t

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Sun, Wanling, Yongji Wu, Hui Li, Xuan Wang, Nong Zou, and Junling Zhuang. "Establishment and Characterization of a New Human Myeloma Cell Line WuS1." Blood 106, no. 11 (2005): 5114. http://dx.doi.org/10.1182/blood.v106.11.5114.5114.

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Abstract A new human myeloma cell line WuS1 was established from the bone marrow of a 45-year-old Chinese male patient with IgGλ type multiple myeloma (stage IIIB). The growth of WuS1 cells is constitutively independent of exogenous growth factors of feeder cells. The WuS1 cell line proliferated consistently as free-floating single cells in suspension, sometimes in small clusters or slightly adherent on the bottom of the plastic culture flask, without forming clumps. The cell line has been maintained without any external growth factors for over a year, and cells frozen in liquid nitrogen can b

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Morimoto, K., E. Robin, MC Le Bousse-Kerdiles, et al. "CD44 mediates hyaluronan binding by human myeloid KG1A and KG1 cells." Blood 83, no. 3 (1994): 657–62. http://dx.doi.org/10.1182/blood.v83.3.657.657.

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Abstract Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Both KG1a and KG1 cells express the CD34 antigen characteristic of the hematopoietic stem cells and HL60 cells do not; accordingly, KG1a and KG1 cells are generally considered as the most primitive and HL60 cells as the most mature of these cell lines. Measurement of cell adhesion to hyaluronan-coated surfaces (using 5

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Morimoto, K., E. Robin, MC Le Bousse-Kerdiles, et al. "CD44 mediates hyaluronan binding by human myeloid KG1A and KG1 cells." Blood 83, no. 3 (1994): 657–62. http://dx.doi.org/10.1182/blood.v83.3.657.bloodjournal833657.

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Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Both KG1a and KG1 cells express the CD34 antigen characteristic of the hematopoietic stem cells and HL60 cells do not; accordingly, KG1a and KG1 cells are generally considered as the most primitive and HL60 cells as the most mature of these cell lines. Measurement of cell adhesion to hyaluronan-coated surfaces (using 51Cr-label

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