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Rozprawy doktorskie na temat „CD8+ Treg cells”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Durost, Philip A. "Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/936.

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Homeostasis of human T cells is regulated by many factors that control proliferation, differentiation of effector cells and generation of memory. Our current knowledge of the mechanisms controlling human T cell homeostasis in vivo is based on experiments in small animal models. However many differences exist between immune systems of mice and humans, including cell composition, function, and gene expression. Humanized mouse models have shown great value in the study of human immunobiology. I have used novel humanized mouse models to examine the role of human MHC (HLA) and human IL2 in CD8 T ce

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Durost, Philip A. "Evaluation of IL2 and HLA on the Homeostasis and Function of Human CD4 and CD8 T Cells." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/936.

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Homeostasis of human T cells is regulated by many factors that control proliferation, differentiation of effector cells and generation of memory. Our current knowledge of the mechanisms controlling human T cell homeostasis in vivo is based on experiments in small animal models. However many differences exist between immune systems of mice and humans, including cell composition, function, and gene expression. Humanized mouse models have shown great value in the study of human immunobiology. I have used novel humanized mouse models to examine the role of human MHC (HLA) and human IL2 in CD8 T ce

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Huang, Wenting. "Immunology and Genetics of Autoimmune Biliary Disease." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447691320.

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Polak, Katarzyna. "Role of the Eos and Helios transcription factors in regulatory T cell biology." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ011/document.

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Les facteurs de transcription Eos et Helios ont été décrits comme étant des modulateurs des fonctions des cellules T régulatrices (Treg). Nos résultats suggèrent qu’Eos et Helios ne sont pas nécessaires, ni pour la différenciation, ni pour les principales fonctions des cellules Treg CD4+. Cependant, les cellules Helios-/- présentent une meilleure activité suppressive et à un profil transcriptomique de cellules Treg activées. Pour tester si Eos et Helios coopèrent pour réguler les fonctions des cellules Treg, nous avons analysé les souris doubles mutantes. Nos découvertes indiquent que la perte

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Fernandes, Reginaldo Keller [UNESP]. "Alterações transcricionais em células dendríticas e células T CD4+ humanas em resposta ao Paracoccidioides brasiliensis." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150253.

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Submitted by REGINALDO KELLER FERNANDES null (regiskeller@msn.com) on 2017-04-12T12:10:23Z No. of bitstreams: 1 Tese Dr definitiva.pdf: 5601863 bytes, checksum: 50eec58640e31a0c12ce54dde368d5a3 (MD5)<br>Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-04-17T20:28:15Z (GMT) No. of bitstreams: 1 fernandes_rk_dr_bot.pdf: 5601863 bytes, checksum: 50eec58640e31a0c12ce54dde368d5a3 (MD5)<br>Made available in DSpace on 2017-04-17T20:28:15Z (GMT). No. of bitstreams: 1 fernandes_rk_dr_bot.pdf: 5601863 bytes, checksum: 50eec58640e31a0c12ce54dde368d5a3 (MD5) Previous

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Fernandes, Reginaldo Keller. "Alterações transcricionais em células dendríticas e células T CD4+ humanas em resposta ao Paracoccidioides brasiliensis." Botucatu, 2017. http://hdl.handle.net/11449/150253.

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Orientador: Ângela Maria Victoriano de Campos Soares<br>Resumo: A paracoccidioidomicose (PCM) é uma micose sistêmica endêmica na América Latina, principalmente no Brasil, Argentina e Venezuela, e que promove um importante impacto na saúde pública. Seu agente etiológico é um fungo termodimórfico pertencente ao gênero Paracoccidioides que compreende o Paracocidioides brasiliensis (Pb) e suas espécies crípticas S1, PS2, PS3 e Paracoccidioides lutzii. As consequências da interação do fungo com as células da resposta imune inata, tais como as células dendríticas (DC), destacando a capacidade destas

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Sérazin, Céline. "Raffinement de l'identité des lymphocytes T régulateurs CD8+ chez l'Homme grâce à l'utilisation des technologies multi-omiques." Thesis, Nantes Université, 2022. http://www.theses.fr/2022NANU1016.

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Les cellules T régulatrices CD8+ (Tregs) ont été les premières cellules suppressives signalées en 1970, mais elles ont été mises de côté pendant des années en raison du manque de marqueurs permettant de les définir correctement. Notre équipe a démontré que les Tregs CD8+ identifiés par une expression faible et/ou négative de CD45RC, une des isoformes de la molécule CD45, montrent une puissante activité suppressive in vitro et in vivo, alors que les cellules exprimant des niveaux élevés de CD45RC ne le font pas. Dans cet article, nous nous sommes penchés sur l'hétérogénéité au sein des lymphocy

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8

Akamatsu, Masahiko. "Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19." Kyoto University, 2020. http://hdl.handle.net/2433/253464.

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Varikuti, Sanjay. "Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis." TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/113.

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Toxoplasmosis is an important cause of congenital disease, and it is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome. The need for a reliable experimental model of this infection is crucial not only for achieving a better understanding of the patho-physiology of the disease, but also for developing better methods for evaluating new therapeutic regimens. The purpose of the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with Toxoplasma gondii. T regulatory (Treg) cells have been shown to play an

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10

Ebner, Friederike. "The role of microglia phenotypes in modulating CD4 + T cell responses." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16882.

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Die Invasion von Leukozyten in das zentrale Nervensystem (ZNS) ist ein wesentlicher Bestandteil bei der Pathogenese von Hirnverletzungen sowie akuten und chronischen Entzündungsvorgängen im Gehirn. Mikrogliazellen, die überwiegende Population immunkompetenter Zellen des ZNS, stellen die erste Verteidigungslinie im Hinblick auf Verletzungen und Erkrankungen des Gehirns dar. Im Rahmen vieler neurodegenerativer Erkrankungen wird die Zerstörung von Neuronen, aber auch die kollaterale Gewebsschädigung auf die Aktivierung der Mikrogliazellen zurückgeführt. Die vorliegende Arbeit beschreibt erstmali

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11

Shoemaker, John. "Molecular mechanisms for the regulation of the Il-10 gene in CD4 T cells : comparison of IL-10-Treg and CD25+Treg." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427840.

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12

Benfatto, Cinzia. "The phenotype, functions and cytokine properties of 5-azacytidine induced Treg-like FOXP3+ CD4+T cells." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/the-phenotype-functions-and-cytokine-properties-of-5azacytidine-induced-treglike-foxp3-cd4t-cells(043c9617-63bc-4965-9f9e-14988b0759e1).html.

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Myelodysplatic Syndrome (MDS) is a group of premalignant diseases characterised by ineffective erythropoiesis and categorised into risk groups ranging from low/intermediate to high-risk, based on the risk of disease progression toward acute myeloid leukaemia (AML)1. Expansion of CD4+CD25hiCD127lowFOXP3+ (Tregs) is a characteristic feature of high-risk MDS2. Although the only curative treatment for high-risk MDS is bone marrow transplantation, this is not always available due to age or lack of a compatibile donor. Nevertheless, treatment with the hypomethylating agent 5-Azacytidine (5AzaC) can

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13

Sánchez-Guajardo, Vanesa María. "Kinetics and competitive capacities of Th1 vs. Th2 CD4+ T cells : the role of Stat6 and Stat4 in CD4+ T cell homeostasis." Paris 6, 2005. http://www.theses.fr/2005PA066547.

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14

Kolodin, Dmitriy Pavlovich. "Dynamics of Tissue-Resident Regulatory T Cell Populations." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11555.

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In recent years, there has been a worldwide increase in obesity, which parallels a rise in pathologies, including type 2 diabetes, collectively termed the metabolic syndrome. Chronic, low-grade inflammation has been implicated as a major link between these diseases. Recent work showed the presence of a unique subset of CD4+Foxp3+ regulatory T cells residing in visceral adipose tissue (VAT Treg) with PPAR-g being the key transcription factor responsible for their phenotype and function in controlling adipose tissue inflammation and, thereby, insulin sensitivity. VAT Tregs inversely correlated w

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15

Portella, Renata Siqueira. "Presença de células dendríticas ativadas e das células T CD4+CD25hi na miocardite aguda e crônica da doença de chagas, em camundongos de linhagens resistente e susceptível." reponame:Repositório Institucional da FIOCRUZ, 2013. https://www.arca.fiocruz.br/handle/icict/7300.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2014-02-07T18:23:30Z No. of bitstreams: 1 Renata Siqueira Portella.. Presença de células....pdf: 2025004 bytes, checksum: a85d3195f20f2a79bd6ff1b32049c260 (MD5)<br>Made available in DSpace on 2014-02-07T18:23:30Z (GMT). No. of bitstreams: 1 Renata Siqueira Portella.. Presença de células....pdf: 2025004 bytes, checksum: a85d3195f20f2a79bd6ff1b32049c260 (MD5) Previous issue date: 2013<br>Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. S

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16

Vokaer, Benoît. "Etude des lymphocytes régulateurs en condition allogénique: effet pro-Th17 et impact du blocage B7-CD28." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209524.

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Summary<p>Immune homeostasis relies on a subtle balance between fight towards pathogens and inhibitory mechanisms that prevent inappropriate responses against self and environmental antigens (allergy). Regulatory T (Treg) cells play a central role in this balance. Optimizing Treg effects represents a promising approach for new stratetiges aiming to induce or restore tolerance against allo or self antigens. The first part of this work demonstrates that CD4+ lymphocytes that secrete IL-17A (Th17) promote allograft rejection in a murin model of skin transplantation with minor antigen disparities.

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17

Simonetta, Federico. "CD4+ FOXP3+ Regulatory T celles Homeostasis : role of interleukin-7 and implication in HIV infection pathophysiology." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00769935.

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Regulatory T cells (Treg) represent a crucial CD4 T cells subset involved in maintenance of immune-tolerance. Since their first description important efforts have been undertaken to better understand their biology, their development and their mechanisms of action. However, little is known about factors controlling Treg peripheral homeostasis. The aim of this thesis work was to better define mechanisms involved in governing Treg homeostasis and to investigate the eventual contribution of perturbation of Treg homeostasis in human disease. In the first part of this thesis work we tried to define

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18

Zago, Claudia Augusta. "O papel das células Treg e da IL-2 na resposta policlonal de células CD4+ durante a infecção pelo Plasmodium chabaudi." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-03062008-172716/.

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Durante a ativação policlonal induzida pelo P. chabaudi a maior fonte de IL-2 são as células CD4+ ativadas, além disso, acorre a expansão de células Treg. No dia 7 após a infecção, a ausência de células Treg leva a uma exacerbação da ativação de células CD4+, além de altos níveis de anticorpos anti-P.chabaudi e auto-anticorpos. A neutralização da IL-2, com Mab anti-IL-2 JES6-1, na fase aguda da infecção leva a uma redução no número de células Treg. No dia 20 de infecção, a freqüência de células CD4+ ativadas esteve elevada e as células Treg voltaram aos níveis basais. Experimentos in vitro mos

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MURATORI, FLAMINIA. "Characterization of immunologic mechanisms in rare childhood chronic inflammatory diseases: implication for specific therapeutic intervention." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/573.

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A partire da osservazioni in clinica di pazienti con rare malattie genetiche della regolazione della risposta immune, in questo studio abbiamo analizzato le alterazioni delle vie coinvolte nei meccanismi di malattia con lo scopo di identificare target terapeutici specifici . In particolare lo studio si è focalizzato su due condizioni, l’una caratterizzata da un’anomalia nella risposta immune innata con flogosi cronica, l’altra caratterizzata da un’alterazione dei meccanismi di mantenimento della self tolerance: i) Una rara malattia autosomica dominante chiamata sindrome PAPA (pyogenic s

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20

Jurewicz, Mollie M. "The non-classical MHC-II molecule DO regulates diversity of the immunopeptidome and selection of the CD4 regulatory T cell lineage." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1030.

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Presentation of antigenic peptides on MHC-II molecules is essential for induction of tolerance to self and for effective immunity against foreign pathogens. The non- classical MHC-II molecule DO (HLA-DO in humans, H2-O in mice) functions in selection of MHC-II epitopes by competitively inhibiting the peptide exchange factor DM. Previous studies have suggested a role for DO in development of autoimmunity and in the immune response to retroviral infection, presumably via modulation of the MHC-II peptidome, but the precise effect of DO has been difficult to discern. Through characterization of th

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21

Malátová, Iva. "Imunitní odpověď a nádorové mikroprostředí při léčbě polymerními cytostatiky." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436131.

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Chemotherapy is still one of the most widely used anticancer therapies. It is mostly about inhibiting the proliferation of rapidly dividing cells, so it is not selective for tumor cells. As a result, many undesirable side effects are associated with chemotherapy. The disadvantageous properties of chemotherapeutics can be largely eliminated by using conjugates of polymers with low molecular weight drugs. An example of such a conjugate is a doxorubicin-linked HPMA polymer. In addition to the properties obtained by polymer binding, such as achieving solubility in aqueous solutions, reducing syste

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22

Mohammed, Ali Haider. "Role of B cells in the generation of thymus-derived regulatory T cells." Doctoral thesis, 2016. https://depotuw.ceon.pl/handle/item/1934.

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Pochodzące z grasicy, naturalne limfocyty T regulatorowe (tTregs, thymusderived regulatory T cells, lub nTregs, natural regulatory T cells), charakteryzujące się fenotypem CD4+CD25+Foxp3+, mają istotne znaczenie dla działania układu odpornościowego ze względu na ich zdolność do hamowania fizjologicznej i patologicznej odpowiedzi immunologicznej oraz kontrolowania odpowiedzi na antygeny własne. Z tego powodu Tregs pochodzące z grasicy odgrywają kluczową rolę w utrzymaniu tolerancji na antygeny własne i homeostazy układu odpornościowego. Limfocyty te powstają w grasicy, po czym migrują do obwodo

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23

Gerriets, Valerie. "Glucose Metabolism in CD4+ T cell Subsets Modulates Inflammation and Autoimmunity." Diss., 2014. http://hdl.handle.net/10161/8653.

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<p>Understanding the mechanisms that control T cell function and differentiation is crucial to develop new strategies to modulate immune function and prevent autoimmune and inflammatory disease. The balance between effector (Teff; Th1, Th2 and Th17) and regulatory (Treg) T cells is critical to provide an appropriate, but not excessive, immune response and therapies to induce Treg or inhibit Teff are likely promising treatment strategies. It has recently become clear that T cell metabolism is important in both T cell activation and differentiation. T cells undergo a metabolic reprogramming upon

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24

LA, TORRE VALENTINA. "Distribuzione delle cellule CD4+CD25+FoxP3+(Treg) nel sangue periferico ed interazioni dinamiche della reazione immunitaria nei pazienti con adenocarcinoma del pancreas." Doctoral thesis, 2014. http://hdl.handle.net/11573/917846.

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OBJECTIVES: CD4+CD25+FOXP3+ T cells are an heterogeneous population of cells playing a key role in maintenance of the immune system’s tolerance of both foreign and self-antigens. They can inibit immune responses mediated by T effector cells. Patients with a variety of cancers have an enlarged pool of Treg in their peripheral blood, in tumor-draining lymph nodes and in the tumor microenvironment. Pancreatic cancer remains a major unsolved health problem, with conventional cancer treatement having little impact on disease course. Poorly prognosis in pancreatic cancer (PC) patients has been co

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25

Teixeira, Vítor Emanuel Coutinho. "Thymic activity and regulatory CD4+ T cells in the immune reconstitution of HIV infected individuals : two (in)dependent factors?" Master's thesis, 2012. http://hdl.handle.net/1822/24480.

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Dissertação de mestrado em Ciências da Saúde<br>The Human Immunodeficiency Virus (HIV) infection is a major health problem worldwide estimated to affect about 34 million people. The hallmark of HIV pathogenesis is the gradual loss of the CD4+ T cell compartment along with a chronic state of immune hyperactivation. As infection progresses, HIV weakens the immune system to a level of profound immune dysfunction, which leads to the onset of Acquired Immunodeficiency Syndrome (AIDS)-related and non-related illnesses and ultimately to death if not treated. The introduction of Highly Active Antiret

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